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    <accession>A0A098D6V1</accession>
    <accession>A0A0E0RTV3</accession>
    <name>A0A098D6V1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FGRAMPH1_01T05747</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D6V1"/>
    <dbReference type="STRING" id="229533.A0A098D6V1"/>
    <dbReference type="EnsemblFungi" id="CEF74678">
        <property type="protein sequence ID" value="CEF74678"/>
        <property type="gene ID" value="FGRRES_12124_15979_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05747"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098D6V1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF6">
        <property type="entry name" value="VIC POTASSIUM ION CHANNEL, BETA SUBUNIT (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="308"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF74678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="615" mass="67789" checksum="F8AAE99604055BE9" modified="2015-01-07" version="1">MESPSGDPQRSDVIHEVRHEKPATDGGLVAWLGVVGAWLMFFITWGPAGSFGVFEAYYKSRMLSSYSESTIAWIGGIVFPILFNALEPKVGFGWTIRVFGFLQLVFGLAALGLLLQMPQKSTKPRRLFEWRAFTEIPYTTFCVGCFCQYLSYWIPLFYLVTYGRSVLGMSDAMSSYLLSILHGSSAVGRILPNLLMPKFGAMPVVFTSTVMCAVLLFAWIAIRQSAGFIVFCVLFGISSGTFVAANPVATLHPTITPSLTIAGERLGMNWLISGLGTLLGAPIAGTLSRPDNGQFLHAQVFTGCIMVDKAFACMKAAYDCGINFFDCAEGYADGEGERIVGECVCKFGWKRNDLVISTKINWGGSYGELAANNYGLSRKHIIEGLDASLERMGLSYVDLVYAHRPDRKTPIEETVRAFNHVINMGKAFYWGTSQWSADEIATAWRYADKLGLIGPTMEQPEYNMLTRTKVESEFVHLYREVGTGLTVFSPLAMGLLTGKYNDGIPDDSRLGVSDDKFVKLTKSEFGNEEGKKMLDKIARLKPVAESLGTSQAILALAWVLKNKNVSSAITGASRPEQILESVKVFSILPKLTDEIMEEIDNILGNRPTPYTSRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DA61</accession>
    <accession>A0A0E0RVP7</accession>
    <name>A0A098DA61_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T07035</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DA61"/>
    <dbReference type="EnsemblFungi" id="CEF75322">
        <property type="protein sequence ID" value="CEF75322"/>
        <property type="gene ID" value="FGRRES_15569"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07035"/>
    <dbReference type="InParanoid" id="A0A098DA61"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF75322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="58" mass="6105" checksum="D72B291484974B9E" modified="2015-01-07" version="1">MGHLETPTSFELGFVKDKRGSSPSPVAPIDSDTMPFSNSASARGAANDIPMSQPQLVE</sequence>
</entry>
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    <accession>A0A098DCL7</accession>
    <accession>A0A0E0RY67</accession>
    <name>A0A098DCL7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T08779</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF76192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DCL7"/>
    <dbReference type="STRING" id="229533.A0A098DCL7"/>
    <dbReference type="EnsemblFungi" id="CEF76192">
        <property type="protein sequence ID" value="CEF76192"/>
        <property type="gene ID" value="FGRRES_13822_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08779"/>
    <dbReference type="eggNOG" id="ENOG502S8TM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DCL7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="537"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF76192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1028" mass="115894" checksum="8C191E6BE53FFE4B" modified="2015-01-07" version="1">MPAHEEVADGSSLDDNFGRLNVQDKDTSEYDSVHNKTHDDDNWRASNYTARSVYLARREYILESGELDTDGPTTQQRQNIFFANEHYVILALDRLPSMVNEFNTIRRHAVEIIKSTDPMSSERAIRFGYLGDQAIDFSELRRKCCEAVYAAFTAADSACDDLGNPEENNAPDEPGMKTEETSAPKGRAEDKDVPRRGSHCCSVALNIAARVLEASTAREMAQNSLSGAHLDDLILIIETHKPPTQSQPWEADMPEKPGYHHVYALLGCLMATAYVRHCFAIETMYLDRAISNLDIAVLKMPETPFKKFRQDLREVRNEVQRLQVFFQRIEMEDDPAIDSFLCAVCLDLKPTVGFHDTEYPYHRMEFGRICQKATMRCRSCAILRDSTASMYPLFGMSWPDIQGLNYSNRSVGQRWFGESEDFLADITWGRNGALRIELVSFYLGTEDPFIASFELFRSYGTVAPWDIIGIGTRIQHDVTSPEAWDMIRGWIGDCINNHEDCKAASEDRPFPTCVVAVGDDETEPHLFIPNSDDHGRYIALSHCWGDVMPLKTTKACFAEFCQSIDFARFPRTFQDAIIVCRKLNIKYLWIDSLCIIQDDEHDWAVESPKMCDVYQNAYLTIAAAAAHNSSKGLFHSRPFSAQTTFTTVSKNDDKVEEVEIFARPWNSQGHWIDNIGDGPWCRNHNPLEKRAWTLQEHVLSRRILRFAAHELVWQCREVHLCECRPGSHLSKESLRLINMDAMVAGTKPSYMARVMNPLVVWLEIIASFTKRAITRETDRLPAVSGIAAALATLLKTEYIAGMWKDRLERTLCWHVAQSTTSRHEAYYAPTWSWASIMGTVLTEYTIHMNPLPQTKVVDVQYSPATANPFGSVSYAKLTITGILLNVSVSLLDPCPDDGTLFQMEICNKSLLETDMELSIECPAFPDFLTAAGETPELVHGDKVSLLLLSCKVYGQGFDSMVGMILAEASGDECQLSDTIYHRIGTGEMNLRSTDRAQGEWKGNPNHGLAWYMATHLSARSCVATVVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DER6</accession>
    <accession>A0A0E0S097</accession>
    <name>A0A098DER6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T10237</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DER6"/>
    <dbReference type="EnsemblFungi" id="CEF76922">
        <property type="protein sequence ID" value="CEF76922"/>
        <property type="gene ID" value="FGRRES_15494"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10237"/>
    <dbReference type="InParanoid" id="A0A098DER6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="57" mass="5925" checksum="838C31BEE864A480" modified="2015-01-07" version="1">MDGGRLAQHKQGGLDEVDVVGLGYLESTAMRGGVEKSETTRGKKGDDDDGISAIFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DIZ9</accession>
    <accession>A0A0E0S4I2</accession>
    <name>A0A098DIZ9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG03578.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T13207</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DIZ9"/>
    <dbReference type="EnsemblFungi" id="CEF78407">
        <property type="protein sequence ID" value="CEF78407"/>
        <property type="gene ID" value="FGRRES_16240"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13207"/>
    <dbReference type="eggNOG" id="ENOG502S3ED">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DIZ9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF78407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="541" mass="60089" checksum="346EAC231F6646F1" modified="2015-01-07" version="1">MPYKSSRFFLLNVLQTKAPVAISLVMVNFGVSRACDACKKRRKKCDETRPACLRCVRSRYNCPGYKDDSLLLFRHYSPANKIVNPTLEKWSPNANYMLEATAVDIFLDELVVRSLDRNHSRGFLDGMHGTFAASDPKSTLMSAAKVVVLASLANRYRKESLFSMVRKQYGQLLREYVTSLSLPSESLSPEQFFTAVLLGIYELMACNISSPTRHLVHVQGLGSILQRGISSSTSTSHIGVHLPGTWLISKGAVLSRNRPVDLFPADMDTSQAHIQGAGILCPPLNHSPQRSLDQIMVGLAPLTARSEKILANPAPSRSALLELYQALVVFHDEIALWADNQPPAWQPEVVGHISQESLTPEVIPWICSGPVEKYFDLYVGTAWNSWRSMYIVWLDQLYHVSNALGQHHLIPHYVKTVDSLVAGLKASIPYHLSRNVEEYIKRVNAGVPDLQANHLSGGLLLFHHLYSIGRCTVVDASTRQYLANVLRWIGNEMGIGNATVLAECLQPDEQGPSVLQNSKISFMDALEGYYLITASMLSKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DJ53</accession>
    <accession>A0A0E0S639</accession>
    <name>A0A098DJ53_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T14323</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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        <property type="protein sequence ID" value="CEF78964"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14323"/>
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        <source>
            <dbReference type="EMBL" id="CEF78964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="40" mass="4580" checksum="82CF24EBC2164431" modified="2015-01-07" version="1">MDPKMIKLIKQRYRQSQLLVNNCDMLSASQNILSGTKSLL</sequence>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
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    <dbReference type="EnsemblFungi" id="CEF77991">
        <property type="protein sequence ID" value="CEF77991"/>
        <property type="gene ID" value="FGRRES_12482_M"/>
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        <property type="component" value="Chromosome 2"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="1"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
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                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
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                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
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    <dbReference type="EnsemblFungi" id="CEF79738">
        <property type="protein sequence ID" value="CEF79738"/>
        <property type="gene ID" value="FGRRES_16074"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15879"/>
    <dbReference type="eggNOG" id="ENOG502SKRG">
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
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        <location>
            <begin position="17"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF79738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="404" mass="43453" checksum="84FDB0AA6091046A" modified="2015-01-07" version="1">MKALFLSMLWPAVACAAACKPQPPKSKAACKLSALSGVDLSVGFDYEGDCVPSTGTLNSFMIFVDFSDAEPVQSETPQSLYEALVPRTIEWYKQASYGALSLNITADLSKFYRMPTSAASYGWERGLTWAEHQVYIQDALDAYTANGTRPPPPESDVLYVIPVISAGVRGISRSIAFNTRANTRQGNYVARKTVTVATDAFTTWGPKSWITLAHETGHTMCMADYYPFENLGLGYYVGGWSAMGDVSGIGPDFFAWDKWRLGWINDNSIDCVVDRGTSEHTLTPLESKTSDNDTKAVVIAVNQTSALVAEVRTPEGLDSGVCAPGVLLYTIDALVNSGSGPVRVVDVTPGSGGCGTDSVYDKNDGTLSLDTGRVSSYTVPGWGVKVTVVKQTEKAYTIQVDAEI</sequence>
</entry>
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    <accession>A0A098DQ77</accession>
    <accession>A0A0E0SAQ1</accession>
    <name>A0A098DQ77_GIBZE</name>
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            <fullName evidence="2">Chromosome 4, complete genome</fullName>
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    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T24851</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DQ77"/>
    <dbReference type="EnsemblFungi" id="CEF83514">
        <property type="protein sequence ID" value="CEF83514"/>
        <property type="gene ID" value="FGRRES_20370"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24851"/>
    <dbReference type="InParanoid" id="A0A098DQ77"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF83514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="59" mass="6585" checksum="B8BB8CBA123F5BFD" modified="2015-01-07" version="1">MAKRNDLSDSGGPEMEIVPGIWKNQPRSSPLIRRNCLGQAARGWAGRGRQRSDVKYDTT</sequence>
</entry>
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    <accession>A0A098DU83</accession>
    <accession>A0A0E0SER9</accession>
    <name>A0A098DU83_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
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        <name evidence="3" type="ORF">FGRAMPH1_01T25531</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DU83"/>
    <dbReference type="EnsemblFungi" id="CEF84932">
        <property type="protein sequence ID" value="CEF84932"/>
        <property type="gene ID" value="FGRRES_07739_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25531"/>
    <dbReference type="eggNOG" id="ENOG502RZM0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DU83"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="95"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="566"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF84932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84932"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <sequence length="684" mass="77400" checksum="F72F02262292BAE1" modified="2015-01-07" version="1">MAETQPHLLRYRKRSVWILAFYLPILIVPWVLTCILMHRPVFLPSYINRHGDYSMTDMQKIQDWSTATNILNRIAATLGLPIVSVLMAQAVVVYSQQRKKGQENKLNVLQLFALSDRGRMDLPILWTSCFGARSRSSRFLWLAAGLVLVTITQPPLQSLLVPYDPLTVITCNDNPVEITNRDKTCNGTGAESRVVGIDPEPNVMEMIPRNLAANLIRQKIKSFSMSDVQTNLWHKVTNYIPFAVEQQRAQTFGWIQKRRPMPFFAIFNHTGFATSGIKATVCVEGNHSDVPWTRSRDRQDIHETMWLRLEVAQQPDGSREDGQALLEDVTAFNLSCRASSTRGYFELGNHWNNQVFGPLLDKWPTRDDIRKNFNDYGSFVGKYKHPDRRPVTVDPALEPDLHVNCDSPPNLLGDFGMGTTGPLTLVAISLFGNGSFFHLASKRPQKDMNYTMRDICESENYPFQRIVLDHLHYTKLCAGGLSMYREDYPPAGNYRGNVKYELLPIFVARILETFNDLKEAESLLEMGMFFANKVLLRESASVFGTVWSRWIFSSPGWKIVKPQKTVMAIVVISAFIAVQCICLVWLACSVHNWIDFAEEDFEVPIKKMESVQEKKQTTSTDASLESDAPNVQDAEEASSTPQDDESQPDNSLILSLGGDYPMSSAYTAADWFGQRRRKGQGGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DWV6</accession>
    <accession>A0A0E0SHB1</accession>
    <name>A0A098DWV6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T16655</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF85824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DWV6"/>
    <dbReference type="EnsemblFungi" id="CEF85824">
        <property type="protein sequence ID" value="CEF85824"/>
        <property type="gene ID" value="FGRRES_17269_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16655"/>
    <dbReference type="eggNOG" id="ENOG502S0B1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DWV6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099:SF7">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF85824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="508" mass="57298" checksum="D7FCDB8E138E4D43" modified="2015-01-07" version="1">MEFSLQASDPTVTYWRSLRVSDQSIRDEIICVELVTSLTTTLTRLSSWDSPYLTPLSYARKHLQSNSKIDRKKPLSFQRPSGKRILCTGKRQGIFAIGGHVQYDGAAGGDTTEGDTTSSNAQVAIRWDGYSTLRLPLADDTTQLNTPVTMDADNIWTDFNLAAYGILETINQTLVQSKHSEKRAVAVKAELCKLDVFSAESDTSQPLVNNPDLGRQMGSLVVCLPVAHKGGQIAFRHDGQQVEFDGASQHSETIQWAAFLSACEHEVLPITEGHRVMLTYNLVWSTWGHGFMANQRHILDQESTHFYTDLEKLIEKIKSTGERKQSRPFSSCKEIDHMLKGIDMVVYQALVRFVCNVSVGAVLDDSRYVEGELESKQMELERLAELANNPNARRSRRHYYDDSDLENTFCITEDLSDLCIDDWYRGDDDSYVPNPLRHLDGYSREKVHWLNHAPDTTTHQELALSVYMVAESEPECASFYSSVAIFARVGEEVDKDDEEDEEVDEEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098E091</accession>
    <accession>A0A0E0SKR6</accession>
    <name>A0A098E091_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG11450.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T22097</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098E091"/>
    <dbReference type="STRING" id="229533.A0A098E091"/>
    <dbReference type="EnsemblFungi" id="CEF87029">
        <property type="protein sequence ID" value="CEF87029"/>
        <property type="gene ID" value="FGRRES_17545"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22097"/>
    <dbReference type="eggNOG" id="ENOG502RM4B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098E091"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
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            <begin position="1"/>
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            <begin position="21"/>
            <end position="387"/>
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        <location>
            <begin position="121"/>
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        </location>
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        <location>
            <begin position="310"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF87029.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF87029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="387" mass="42400" checksum="BD4242715FC8D31D" modified="2015-01-07" version="1">MHIGFQTLAIALGASSLVAAAPAEASAVELMQNLNRQAINALESTFAQSTERSTAKKCTLSNAAVRRDWRALSKKEKKAYIKAVLCLREKPSKADPAFAPGARTRYDDFVAVHINQTRSIHGTGNFLTWHRYFTWAYEKTLQDECGYKGTQPYWNWFETRDFAVDPVFDGSDTSMGGDGEFFKHNGSSGGRGTILLPSGNGGGCIKSGPFAGAVANLGPPAPSMDGMEATTTPLEYNPRCLRRDLTRYAVDQWLTYPNLHNVTLGVASRNIDIMQTEFQGRFPDGFLGLHGAGHYTMGGDSSDLYSSPNDPNFFLHHSMVDRVYWIWQALHPKQANDIAGTITIGNMPPSRDALKSDPLNMGVNAREITIGDALNTLSGSPLCYIYL</sequence>
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    <accession>A0A098E0E3</accession>
    <accession>A0A0E0SKW4</accession>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098E0E3"/>
    <dbReference type="EnsemblFungi" id="CEF87077">
        <property type="protein sequence ID" value="CEF87077"/>
        <property type="gene ID" value="FGRRES_15620"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20395"/>
    <dbReference type="InParanoid" id="A0A098E0E3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF87077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="88" mass="9748" checksum="44F869C5F6DFCF3A" modified="2015-01-07" version="1">MIQLRHPRGPVTGSRATHGRVTKKRQLSAIDISFEKRRADCGGGVTRVDLAESNEGVHHDCDRGSRLVIRMKFCPFGGHRVSGIDPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RM33</accession>
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        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RM33"/>
    <dbReference type="EnsemblFungi" id="CEF72308">
        <property type="protein sequence ID" value="CEF72308"/>
        <property type="gene ID" value="FGRRES_15735"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01011"/>
    <dbReference type="eggNOG" id="ENOG502SUJA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0RM33"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057082">
        <property type="entry name" value="PH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057081">
        <property type="entry name" value="PH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23076">
        <property type="entry name" value="PH_FT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23074">
        <property type="entry name" value="PH_FT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="232"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="355"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF72308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="479" mass="56090" checksum="8DD5959E07AD7B58" modified="2016-04-13" version="1">MEMVLGDQLELHLLQGCCLEGERADLVALQLQGLHNVLPDGNHAHLMMTIEEIRASSQLLFELPEHCKVHFSRVPIVLDYLEILLPCLSRSLRDITTFYEDRSQTRENRWRKMYHSMTDEAGGLSLPQRFILYNRFLTLLRELLTRSLSFDFNTMETTRVQLMELREARNIPPPPIRLNSTSQLDSVLDDDSSTIANIHWSEKIFSLPLPSRTPLKHQQPSKAWGPLVPWEQIQMPSDAKILFMRSFNERQITLVVYESARDNCPYFLLRTFHMGTPWFSLRGAHELVVDRNGSCLQFWRWSESDRCTKRWATLCFLTWEEMVLVYCCFLSFKTRDSQTLRMAANEDLSLWGERKLFQARIVDDNFMHSLIVYEDFVSKGLRLHAAVWEGDLRQCPVWTAFVTHQSASSRWIKRVSKTRVRLADIHLYVFCQEYRQQNQRINRSGAFEIKFVSEEAAKRFRDIFAPSFTDESTTTDTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RPC5</accession>
    <name>A0A0E0RPC5_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">FG01038.1</name>
        <name evidence="15" type="ORF">FGRAMPH1_01T02597</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RPC5"/>
    <dbReference type="FunCoup" id="A0A0E0RPC5">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A0E0RPC5"/>
    <dbReference type="EnsemblFungi" id="CEF73100">
        <property type="protein sequence ID" value="CEF73100"/>
        <property type="gene ID" value="FGRRES_01038_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02597"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0RPC5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090422">
        <property type="term" value="F:thiamine pyrophosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000011">
        <property type="entry name" value="Mitochondrial thiamine pyrophosphate carrier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="12"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="119"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="212"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CEF73100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="323" mass="35269" checksum="0C52F1D4EAD9D4A8" modified="2016-04-13" version="1">MSHKEGHLKDEGSKVQVVAAGGIAGLVSRFVVAPLDVIKIRLQLQPHSLPSQVAALRNGPAYRGAFATLKHILKHEGLTGLWKGNVPAELLYVCYGAVQFTAYRSTTVFLRTAFPSRLPDSAESFIAGAASGAAATSVTYPLDLLRTRFAAQGQHRVYQSLRSAIWDIKRDEGWRGFFRGIGPGLAQIMPFMGIFFVTYESLRSSLEGLHMPWGSGDATAGMCASVISKTVVFPLDLVRKRIQVQGPARSQYVYGNIPEYSTARGAIKTILRTEGFRGLYKGLTISLLKSAPASAVTLWTYEQSLKVMLDWDSSSKETIPNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RRV0</accession>
    <name>A0A0E0RRV0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FGRAMPH1_01T04337</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RRV0"/>
    <dbReference type="EnsemblFungi" id="CEF73975">
        <property type="protein sequence ID" value="CEF73975"/>
        <property type="gene ID" value="FGRRES_15886"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04337"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0RRV0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
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    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
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        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF73975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="513" mass="58012" checksum="6FE97E1615D54335" modified="2016-04-13" version="1">MAGTTFAELHLAFYQWIDETLDHPLGRYFMAGVGSSLVVLLVAIAAFCSRSKTPNVPILLQDEIGNARKRALEYCFNPREVMEKGYKKFKNEVFGLDTQDGLKLVIPPSYLDALKSHPALSFKASIDNDMQIEYTHFGGPPEYVIHAIKANLTGSLPAFAPILHKMARKNMPKVMDWTPVKVHDRVLRLIATNNARAFQGTAASEDEEWLSASTGYVLACFDCIRALKQWHPWLRPLVYRLIPERAAIKDQWAKGRKRVMASMKERQQKGGNIEDPPTMLDHLSNGKHEGMANDIEKQLVHQMNLIAVGTVTTYSSTTQAIYDLATHPEYVPILRQEVESVSRDANGNFTRDSTLAMEKLDSFIKESQRFHSPDLTTFQRAAIADMTLPDGTFVPKGTKLEINTCSIHKDKDLYENPGDFDALRFYKMRQAPGQEAKYQYFSVGREDLSWGFGRHACPGRYLSAINIKLIMAELLMNYDIKLCDGASRPPNIEFEVLCSPDPDYEILLKSREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RS25</accession>
    <name>A0A0E0RS25_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG01853.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T04487</name>
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    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RS25"/>
    <dbReference type="EnsemblFungi" id="CEF74050">
        <property type="protein sequence ID" value="CEF74050"/>
        <property type="gene ID" value="FGRRES_15897"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04487"/>
    <dbReference type="eggNOG" id="ENOG502R6NR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0RS25"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF74050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="560" mass="62668" checksum="65E0092E3B47A996" modified="2016-04-13" version="1">MAGPGGGPPRRSHTKSRKGCDTCKRRHIRCDENFPQCRNCTKHKIRCPYNDVQVPDSERSTTPDKPDLMWTPQIEAAIAEWQRTGIFPLPSLGIYPAPMPHLYSVEDLRLIYHVAALYYQLASIDANNFTLWTRHIPTLLRIGATTPYVMHALLAFSAMHIAFLTDCPLVGSMAYEHRGIALKGLQEAIGSFSRETSDAILAASLVLSWQATDWRSWTQLMQGTSSVIDAMDPWKHESQFGDFIAESSTFPTAPPSPGKDHRPSQPRPEDLEAYQRTLEQVQKVEAHLKHHKEDTTQIQHLIGFLRGSRKISPTLSIAQQFERLQPLRKWLFWMPVGYLQNYHGSPNSLVIIAHLYTVALLMERLFPEIGAAYFGSLSISPVEEIARRLMSINVSGAGTDMQTPLTLMEFPIDTVGQFRSRMGWMHPERTPSFPQFNPRNFTVHESMPSTEHYLYGNPAFSYSTEEMPMLNASGPPPSAVSPLVLSPYPTQQYLNVPSPAYTGAYSPASSTFEGSVAYSDTEEYGSWDMSTLQGGPSSAIQDSPQNYGVGFVTPVQAVWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RU55</accession>
    <name>A0A0E0RU55_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG02480.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T05951</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RU55"/>
    <dbReference type="FunCoup" id="A0A0E0RU55">
        <property type="interactions" value="927"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A0E0RU55"/>
    <dbReference type="EnsemblFungi" id="CEF74780">
        <property type="protein sequence ID" value="CEF74780"/>
        <property type="gene ID" value="FGRRES_16004"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05951"/>
    <dbReference type="eggNOG" id="KOG3075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0RU55"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000014">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF74780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="281" mass="29794" checksum="DFD0CB19C0C0E880" modified="2016-04-13" version="1">MSSSANLVESAKKLAAYQAVNDHLDASYKFVGIGSGSTVVYVVDAIVSKGPEFYKGMTFIPTGSQSKGLIRAAGLNLVNLDERPMVDGLPVPLDVAFDGADEVDEDLNLIKGGGACLFQEKLVAIAAKKFIAVADYRKQSPKLCTTWKTIPIEVLPLSAPDVLVRLRAMGSPKPAIRSGLPAKAGECVTDNGMWLIDAPFSPLLLPKDINSENKGRGENGAWEVNALAEELVRTPGIVEIGLFHGFNGNEAVKLGKESQAQKPIAAYFGLANGEVQVQNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RVK5</accession>
    <name>A0A0E0RVK5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T06951</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblFungi" id="CEF75280">
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    <dbReference type="InParanoid" id="A0A0E0RVK5"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75280"/>
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    </evidence>
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        <source>
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    </evidence>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0S5S9"/>
    <dbReference type="EnsemblFungi" id="CEF78854">
        <property type="protein sequence ID" value="CEF78854"/>
        <property type="gene ID" value="FGRRES_16179"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14103"/>
    <dbReference type="InParanoid" id="A0A0E0S5S9"/>
    <dbReference type="Proteomes" id="UP000070720">
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    <sequence length="283" mass="32813" checksum="219F11A68FA466ED" modified="2016-04-13" version="1">MEANKKLATLEGDDFAEEMMAIIKAACDANSEQNYDDSKDDFFSIIRVRAMEPPVIASLSSVLTSPIEDGDMTSLKMHQLVFYSIISKLSLEQLQPYRSTIKIIMGFDISSFESRSSHYAQTMHLVNNARLLDRFIENPEDVWVPENKFDCISYRTLWERVNTAEQMRPYMHDLFNWQLDACHPPFRPCREQLARFPEVSAAVAAEVMNVAVEDFEHQHFLVDFVSECVPAGKAWYPMRDPVEQMVRVLEGKSKEHLVKDGEEDYLEEAKDWLEVLRKWESNN</sequence>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0S7J8"/>
    <dbReference type="EnsemblFungi" id="CEF79473">
        <property type="protein sequence ID" value="CEF79473"/>
        <property type="gene ID" value="FGRRES_15246"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15343"/>
    <dbReference type="InParanoid" id="A0A0E0S7J8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF79473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="71" mass="8277" checksum="4DDBDF3907C9F1D1" modified="2016-04-13" version="1">MSVREQALPEIARREKRKQLYIVVANDGQSRDISTLPPDSLRIKVLGRLQYPRYLLSFDPDLGLLTWSRHV</sequence>
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    <accession>A0A0E0S951</accession>
    <name>A0A0E0S951_GIBZE</name>
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        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
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        <name evidence="1" type="ORF">FGRAMPH1_01T23727</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF82964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0S951"/>
    <dbReference type="EnsemblFungi" id="CEF82964">
        <property type="protein sequence ID" value="CEF82964"/>
        <property type="gene ID" value="FGRRES_15407"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23727"/>
    <dbReference type="InParanoid" id="A0A0E0S951"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF82964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF82964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="89" mass="9871" checksum="43122717CD824440" modified="2016-04-13" version="1">MRSINRPLPIMPRSRLAAVTSHDSYLTAHVSALDHLVSVDVNTAFRSYFVVDVLPYESGDPMTILAGSLQHRNLSREFTQGISSLSIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SEB3</accession>
    <name>A0A0E0SEB3_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
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        <name evidence="3" type="ORF">FGRAMPH1_01T27105</name>
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    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
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        <lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SEB3"/>
    <dbReference type="STRING" id="229533.A0A0E0SEB3"/>
    <dbReference type="EnsemblFungi" id="CEF84776">
        <property type="protein sequence ID" value="CEF84776"/>
        <property type="gene ID" value="FGRRES_17210"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27105"/>
    <dbReference type="InParanoid" id="A0A0E0SEB3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF84776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="256" mass="28105" checksum="08858B2277F32F65" modified="2016-04-13" version="1">MPSLLRFWRHTIGIPLEAAYGCTELGGPTTRTDSSCDRELKFSIGKPSPGVELKLSEGSEGEILMKSSLLFSGYLGDEAKTKESMTADGFFKTSDYARRVGDEYVMEGRVSTDFIRSGPFKIPIVEVETRLTELSFVTEACIVSIPDRDVGNRVAALVKFSPGFDGNLAIIRDALSEDLALYNLPTALRVLAPGEVIPATDAGKVVRQNVVQQYFTPTGDYELAPSVEVWDLSQKQQKAKAWDWNGVQLSPQGLQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SH52</accession>
    <name>A0A0E0SH52_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG08970.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T28233</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SH52"/>
    <dbReference type="FunCoup" id="A0A0E0SH52">
        <property type="interactions" value="774"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A0E0SH52"/>
    <dbReference type="EnsemblFungi" id="CEF85765">
        <property type="protein sequence ID" value="CEF85765"/>
        <property type="gene ID" value="FGRRES_17138"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G28233"/>
    <dbReference type="eggNOG" id="KOG3327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0SH52"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000679">
        <property type="entry name" value="Thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="10">
        <location>
            <begin position="29"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF85765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="254" mass="28250" checksum="BF3D62E8256A1A4E" modified="2016-04-13" version="1">MSSTTDLATAAIASNAQDDSGNRGAFIVLEGLDRSGKTTQVKLLEQRFVEEGKKVKVMRFPDRTTPIGQMIDNYLKSNVEMDDHVIHLLFSANRWEAVKQIQSLLASGTTILCDRYYHSGIVYSAAKQNPSLTLPWARAPERGLPRPDLVLFLDLTEEQAQARGGWGGEVYERSGMQKRVRELFWGLSMGGKDIAAQGLGLDEGEGWTQEEEDLVVVDAGGSVEEVNEEVWKKVRARVEQVERGEVGRSVRVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2024-10-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SQ84</accession>
    <name>A0A0E0SQ84_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG05168.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T17263</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SQ84"/>
    <dbReference type="STRING" id="229533.A0A0E0SQ84"/>
    <dbReference type="EnsemblFungi" id="CEF88597">
        <property type="protein sequence ID" value="CEF88597"/>
        <property type="gene ID" value="FGRRES_16459"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17263"/>
    <dbReference type="eggNOG" id="ENOG502QQ5A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0SQ84"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010027174" evidence="3">
        <location>
            <begin position="23"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin N-terminal" evidence="4">
        <location>
            <begin position="87"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="5">
        <location>
            <begin position="242"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF88597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="367" mass="40635" checksum="8BD9A10DBD08E417" modified="2016-04-13" version="1">MTSFRSIFILAFIALLAAIALFQTSFKDTTTSTFEVLKTLTPLSYIYSDKITDQQKDNHHLYATEMSVHRAIRKVFLAVEQSEGAGARVRRSIGTPQLRNFSPFLMLDHFSVKPGAGFPDHPHRGQETITYLLEGGMDHEDFAGNRGTLSAGDLQFMTAGKGIVHAEMPQQNADGSANIGLQLWVDLPKELKACEPRYRDLKAPEIPIAKIDDDKVTVKVISGQSHGIDSVKDLAYTPVWFLDIEIQPGGKITQPLPPNWNAFAYTLEGQVIVGNDDQKRVVEQYHNIVFEPEGDVVHFEVDAGATKSARVAIIAGTPLDQPVIQYGPFVLTSKEDVAKALFDYQTHSNGFERAEDWQSEIGKSMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YIC8</accession>
    <name>A0A1C3YIC8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FGRAMPH1_01T04343</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YIC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04343"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YIC8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="8">
        <location>
            <begin position="219"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SCB64307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="663" mass="74136" checksum="C35E9BE33B5DB5AA" modified="2016-11-02" version="1">MSAEERAAAYPSAACMGNDTWYLTSIAWCIDSYCSKNTKPYKIEKFWWTKMIYQVQSIKFSYAEALAQVNTKTPPKPMSPDLTVLNRTISIDDATYNSYLNAVKGYIAIGKNESKYSLLVFLSCVVIPIGFSLLRLLPIPISIRSKFYAYIIDPPAWGKRHSVPTFGLGIVPTRGQALFILYIIAINALATFDGYPRYTPNAYFPDRRYELMRHIGNRAGIIAFANIPVIILYAGRNSLLLRLTNWSYSTFILLHRWVAMVCVIQVILHSLMWLQIMVEAHSHATVVKSPYWQWGIVGTVAFSLLLPFSILPFRRALYEIFLIVHICLAVVVMAGSWYHIWYLFEDTSGFEIWLIIAIAVWGYERFLRILRISRHGIKKAYIRRADEKYLQIDIPDMDAHGHCFIYFPTLSWRVWENHPFSIVNCSKGQLEGQASHSSSSSQVEGKSASPTSASMFKEVGMVAVNTPSSVTATNTTKSGITLFVSPEHGLTARLPEKADTGISIPIFVECSYGHEDPTRFMPTTDYPNTLAIAGGVGVTAVLPALQGSLSMYARPLGTSKLYWGTKNRGLVNTVKRMIVDGDSYRDEEGNGSASNWGHFGAHVTIGSRMDIRQVLTSELQSTAGGTTVIVCGPQQMCDDARNVCAGLARHGVVVRYVEESFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YIQ1</accession>
    <name>A0A1C3YIQ1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T06037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YIQ1"/>
    <dbReference type="STRING" id="229533.A0A1C3YIQ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06037"/>
    <dbReference type="eggNOG" id="ENOG502SQJB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YIQ1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="2">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="651"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB64437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="803" mass="88629" checksum="A0337A6D1B5A2827" modified="2016-11-02" version="1">MPYYSEYQSDRSRRDTQAKLSPQANIGADMTSYYDVSPPASQSPLDLDEYLVPAVEGPPSPERIRQLSKQMKHASHLNRGQRTASTGSSILMTGERGWEQGFENMSITRHSSQRSTTTSGSSSRDRPDSVQVLGKNIFHRRAKSSKSGRRRESSAQSSAASSIYSTEVGSETSLATFKDAIMPTIFARRKSSRDDVALQKKLQISGPFNFQHVTHTPRDQANNSASRTPAQELRMPNFSASTEHVPEPQVSPRSARASALPRRYIKQARSQEQLRTSPPRPIRPPRSPPIEELHSPTLGAPIPPPRSSSRQPRDSDSLAMTGRDRPLTSGGFRHPRPFSPKDTMERASAVPQGFGVVMDQEPLPVDDHRFSHAITTPDDAAWPLPATTNYEPPLPDVPEEEEMMRSPKNTTSTRSSLRASQSVPLLRGPQGSENAAAQRSAGHYKGSVGHIPSIRESWEDDIDYCYEHEADANFEYEWERPSMDTGREAAPGFRLDMFGDDELRELPSVGTAELSPGMLSASRFDMPALSPASHASPESTSDTASPNMGVAMTNNFSLPRGEKGRRPPQLNHTRNDSRASSFRESYGFTLSPSLLIPGDYHQQMLLNETEKQSYLCEDELVHGIVDHDNIYENASNAASHNSLQLSNQRASTSTTATNSTSLSDSTGERHVSTNSTWTNLTRLTSSTSLNKWVEQNDGVRESLIIKSHDDSEEEDTTPPASIEKDTVPELTPFPSVPVSKKPHHKSHASESIVREEVPINKSVEAIKTRRPRARTTSLSAQAPPVGQYALFPRTYAKGSGDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJD7</accession>
    <name>A0A1C3YJD7_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase subunit 4, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FGRAMPH1_01T06503</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 5B family.</text>
    </comment>
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        <property type="protein sequence ID" value="SCB64476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
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        <property type="entry name" value="Cyt_c_oxidase_su5b_sf"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, ISOFORM A-RELATED"/>
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        <property type="entry name" value="COX5B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rubredoxin-like"/>
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    </dbReference>
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        <property type="entry name" value="COX5B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
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        <location>
            <position position="161"/>
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        </ligand>
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            <position position="180"/>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    <sequence length="220" mass="24136" checksum="52F06AB795805ED8" modified="2016-11-02" version="1">MFLQRSAITAARRVAARPAVARTFVTSVARLDASRPATPSEQAAALAGTAEKKVGSYKVLKGTSIDNGVVDSFNGAPRNLEIRTEEDLFGPGAAPGTVPTDLEQSTGLERLEILGKMEGVDIFDMRPLDATRLGTMKDPIMVRSAGEEQFAGCTGFPADSHSVTWLGITRERPIERCPECGSVYKMDYVGPEDDHHHHHPPEFEEPKTFADYIKPEYRYK</sequence>
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<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJT0</accession>
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            <taxon>Sordariomycetes</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="229533.A0A1C3YJT0"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18153"/>
    <dbReference type="eggNOG" id="ENOG502SWSC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJT0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="404" mass="44126" checksum="28962E41909EAF6D" modified="2016-11-02" version="1">MPKAKGQRSMSARNNPIGSRSSRRISNSVAAAKAAATKKTNTQNPVKEERVQEPESDDQETPQDPEDHPSAAENASSNESVDSSADEETNEDEEEENDNDSENDQDEDDDENEGNVANEDNTALQGPAPPGYTWQLVPTTYHGETAGNVASRMFGKKLNAKSSLAKRLFDELAVRPASQRNRNTKLNVSRRSNAEALLCHLTGVRVQTACKNCSRSHGPWHECVIYDGQMCGSCTNCWYNASGSRCTFHDDNQACLFLPAPFPALQMQMQSMRIPTMRMPAILPGTNNVPGQQYLEYANGQTATQKETPLERLQRIGAIQTGISGTPLDRLISRVESAAIELGSRVGEFQEFIQTPAGYLMMAQRAAQDATPSSSTVEELGSDEELGSDEENGSDEENGSDEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKG7</accession>
    <name>A0A1C3YKG7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T20167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKG7"/>
    <dbReference type="FunCoup" id="A0A1C3YKG7">
        <property type="interactions" value="777"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YKG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20167"/>
    <dbReference type="eggNOG" id="KOG2020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YKG7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042565">
        <property type="term" value="C:RNA nuclear export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF3">
        <property type="entry name" value="EXPORTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="3">
        <location>
            <begin position="33"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1231"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1231"/>
            <end position="1240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SCB64922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1264" mass="143368" checksum="32CF2970C94F93DC" modified="2016-11-02" version="1">METNGTSGVVAKMQQALEIVHNPYATSGDRRTAQDYLEEVKDHDEAPLQGFNLASDKSQSPVVRHYALSLLEHAIRYRWSTYTTEQTQAVRQWVLNLGQAIAKEDPAYIRNKTAQLWVEVAKRCWGAEWMDMDSMLYQLWEVPDSAVHKELVMFILENLSDEVFTGDDSVVAMREGVLSKACVEIFTPTSVLVEAFPNRQPGPPVRYGDDGWLSRLSQFLGYCLNSAHSDNDEVKLCIHKGLSSLLSLMPWAIPKAISSARCVEVLCVGLASSHASIQKAALEALHALYCRTNFNDEEFRELVAPMYNRESIDLCRRLFEWSAVDPEDVDEDKYQTLKKLSEMLSCLGDYFDRKFAKLPAEAAKDEFLGLLVQIVQHQSLMVSIPVLVTWTRLLSNRLIGPGEHVSPLIPPLLETCSSRLVRYENLPEDTQDPTFLYLMEDTDTIPERHAFLGNYRRYSSQIIEAVVQLKLVDAIPHILNRTEELLQHLYDGQPPLDKQNYFKHSMPVLRVDAQFTVIEATLKGYTKWRKHRPQDHQQRGPEMEANLETWCNKILEMTFEDPMIRKRTLQLLVYFSTTALNKNATFMLKVLEHILLTWPALEPEYRAFNDSIKDLQGESMVELQRLASEMPDHLLGVYDQIENKVNEMMSSGSLDEKRSIAYRSFLFIIIHRATGVSADAKIQKLREFIDPVKAQWQDENVRNSLKSYGSFCELLGLDKAQAYMANHRAHEIHDWGTRELDAEGLTLQSELEERLKLLPLRSTKSFLAFSVERLDKNSDAFKASYALWEDGFSNILADLLEFLSFAHACHNPDNWAGLPSEMRSTVNRILSDRFWQAGISEGSKDDFYARVMDKKNTMEGLASTIRGSVRFVRETAYAIIYCMSRLERQFYGFQGLSAPLSKALFADSVWLSTHQQSNLLNLVRYLVDDCPVDCREHFLPQVLAACFQQMDAKINGEWDKMERQQQVAADGEAGLKEEMKAESILRQVTYTAVLMVADFLDPTKLNGPIEDGEGTSDSDQAKNYPTLRRFCLTHHEIVEPLLVFCAHGIRMRDTRCCSMILRLFVSLVPEFHLVDGQLPKSVVQSPMEAHLASDKFPIPSSISSAIREYISLHVLKACITSFHEPYFVELQKDLAALIAAIIVYYSPITSTPSDVLLSLPNVSESSLERLSTYMAKPGAHTRQQRALVLDLLKDLKGVSVSEMGKLPKSNGFDNSRGKRSNRSKMAQQFMNDPQAGQNATRAGMNVGRQSTPDGLEGVSNLFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YL17</accession>
    <name>A0A1C3YL17_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T24509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YL17"/>
    <dbReference type="STRING" id="229533.A0A1C3YL17"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24509"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YL17"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="86"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SCB65237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="306" mass="32820" checksum="2D9C243C15564564" modified="2016-11-02" version="1">MRPGPSFRTLMLPCLVRFVPRSSPSKILIGQPADKNIDVGAALRKGQEVAVNVWSGSSVLAPGSSTGTTETIDRVLSPLAQNEVGTIRCVGLNYRKHAAECGLEPPPIPVIFMKPSTSLVDPWPAKGTVPKLSQVDSSGDYEAELAVVIGKTAKNVSEAEALDYVLGYTAANDVSSRTQQLNQSQWSFSKSFDGALPLGPTLVLKSLIPDPSKLHMRGLKNGEVYQESGTDDLIFSVPKIISWLSQGTTLPPGTVIVTGTPAGVGMGRTPKDALRHRDEFAVEILPHIGTLTNIFENEKSEFMTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLC7</accession>
    <name>A0A1C3YLC7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FGRAMPH1_01T26041</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YLC7"/>
    <dbReference type="FunCoup" id="A0A1C3YLC7">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YLC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26041"/>
    <dbReference type="eggNOG" id="ENOG502QTKT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YLC7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF14">
        <property type="entry name" value="FAMILY 17 GLUCOSIDASE SCW10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008687636" evidence="9">
        <location>
            <begin position="18"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="62"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SCB65345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="371" mass="39204" checksum="34B5DA7922BCFDFC" modified="2016-11-02" version="1">MKRFFTSAVAMAAAVAAIPVSRPLIKREPVTTITLTTASTYTQVVAPATPIPIIPTGTATFQGTPVPVPDDQKPPNGSGSKLPCVTCSPSGSSSSGSSGSPGGSNGSKLPGISYAPYRGDHQCKSGDEIKQDISDLAGSYSLLRIYGTECDQVSKIYPCAKANGMKLFLGIWDINDVQSEAKLIIDAIGDDWDIVDTISVGNELVNNGAATPAQVLAAVDEARAILKTAGYNGPVLTVDTFVAVQEHPELCEKSEYCAINAHAFFDPHTFADGAGKWLSDTVQVVKSKLSSDKRVVVCETGWPTKGDSNGNAVPGLTQQGSALRAIREAFSDHPDDLILFSAFNDHWKKPEPATFHAEQFWGIDGKDSASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLE8</accession>
    <name>A0A1C3YLE8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T24017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YLE8"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24017"/>
    <dbReference type="eggNOG" id="ENOG502SYR7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YLE8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
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    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_GRF"/>
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    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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            <end position="74"/>
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            <end position="365"/>
        </location>
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            <begin position="16"/>
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        <location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="SCB65192.1"/>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Nectriaceae</taxon>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
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        <property type="entry name" value="Bifunctional dethiobiotin synthetase/adenosylmethionine-8-amino-7-oxononanoate aminotransferase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684:SF3">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13500">
        <property type="entry name" value="AAA_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SCB65521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="767" mass="84868" checksum="30EB27823F749F40" modified="2016-11-02" version="1">MAPVPALLWRSLRTHQVYGANTDVGKTIFSTVLCNAASKKGDRTWFLKPVSTGAVDEADGWCNHIQRFASSTNHETLFQYDIPCSPHIAAKVSGKPIPSDEAVLAKIHDSVSRYASEGPGWLFLETAGGVHSPGPSGTPQADLYTPLRAPVILVGDSKLGGISQTISAYESLRMRGHDIESILLFQDMKYENYQYLKDYFSKQGGIPVDTVPEPPSRLPDIQQDTEQMREYYASQTSNVSHVLDHLDKRGKQRISRLESLSEKASKSIWYPFTQQKLVTADTISAIDSAHGDYFQVLNKTYENLLQPAFDGSASWWSQGLGHANSRLTLAAAYAAGRYGHVMFAEAIHEPALALAEMMLEGAQNSRFSRVFYSDNGSTGCEVAVKMALRAARLRYGWGPNDNLQILGLKGSYHGDTIGAMDCAEPCVYNEKIEWYEGKGYWFDYPTIQCVEGKWVVSAPNGMGQDQKLESISEVFNLESRLKTEQYRGYEEYIEKTLKKLQDQGRKFGALMMEPIILGAGGMIFVDPLFQRALVDVVRRSPHLFGTKDALPAQGPQWSGLPVIFDEVFTGLYRLGRFTAASFLGTEADISVNAKLLTGGLVPLCTTMASESIFDAFKSDDKSDALLHGHSYTAHAVGCQVAVESVSEMQSMEKNGEWEWAEKDWAEDETQAWSVWSRDFVTDMSHNPQVLGVWALGSVLAISLRDDDGVGYKSLAAKKIQSHLRQGTGSWNAHSRVLGNVFYVMASQKTSRQSIRELQGLLVDALSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YM09</accession>
    <name>A0A1C3YM09_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FGRAMPH1_01T27639</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YM09"/>
    <dbReference type="FunCoup" id="A0A1C3YM09">
        <property type="interactions" value="465"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YM09"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27639"/>
    <dbReference type="eggNOG" id="KOG2682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YM09"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="15"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="343"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SCB65494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="449" mass="48795" checksum="FD9140C10C4B897B" modified="2016-11-02" version="1">MGQEESSMGYSGPPVTLSERSLAAVAASIKSGRSKNIVVLTGAGISTAAGIPDFRSPGTGLYANLARLNLPYAEAVFDISYFREHPEPFYVLANELYPGKFHPTVSHAFIALLARKNLLQMLFTQNIDCLERVAGVPSDRIIEAHGSFAKQRCIECKEEYPGDKMKEHVFGGKVPHCDKEGCKGLVKPDIVFFGEPLPKAFDNNTFQVAMADLVLVVGTSLSVYPFAALPGLAQEGKPRVLFNMEQVGQLGSRSDDVIELGDCDAGIRKFADELGWRDELEALWREIVGDAEADRQNSGREKEAVQDEVERLAAEVGAVVIDDGEGKADAKLEDTKKDVLSYNAPAKLDEEKPKTGHNISEPAADTSSTTATEDKTKESPKTEQLKPENLEKIEAEATKTESLVTEPPRSPPSEEQTSQTETQTETSKDEPTAEPTDSTTKEGESKSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YM60</accession>
    <name>A0A1C3YM60_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FGRAMPH1_01T10261</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase d subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YM60"/>
    <dbReference type="FunCoup" id="A0A1C3YM60">
        <property type="interactions" value="500"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YM60"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10261"/>
    <dbReference type="eggNOG" id="KOG3366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YM60"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SCB65622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="229" mass="26300" checksum="FAD115E4E07BBE27" modified="2016-11-02" version="1">MATRSAALKLDWTKVTSSLGLRGQTVASLQAFKKRNEDVRRKVQQLQEQPTTVDFSQYRSVLKNQAIIDEIEKRFNAFKPVTYDVSRQLKAIDAFEAEAVKNAEATKQAVDLELKDLAATLKNIEEARPFEDLTVDEVAAAEKSIDEKTDQLVSKGRWMVPGYKRRSLATWLWFRRIATFPFRLRVVYSSIVDKRELGAEPRFSSYPKHLQNFPMCFIISYSLNKVSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMW9</accession>
    <name>A0A1C3YMW9_GIBZE</name>
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        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T13269</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YMW9"/>
    <dbReference type="STRING" id="229533.A0A1C3YMW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13269"/>
    <dbReference type="eggNOG" id="ENOG502R6B0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YMW9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02216">
        <property type="entry name" value="cupin_GDO-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047183">
        <property type="entry name" value="GDO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41517">
        <property type="entry name" value="1,2-DIOXYGENASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41517:SF1">
        <property type="entry name" value="CUPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="3">
        <location>
            <begin position="100"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SCB65829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="192" mass="21600" checksum="2584C36E007F0DD4" modified="2016-11-02" version="1">MGNYTSAVASDDGTTDEMKQYLSELPSKNLEPLWSQMSMMVPPSPNPTAKPHMWTYKEALPHLETAAKLVPEEKAERRVLMLVNPSMQSPYTTDTIYGGLQIVKPGETAPAHRHLAFAARFIIDGEGFTAVEGKKMPLVRGDVVITPIWHWHDHGNESDKPVIWLDMLNLPLFRFAPVHFAQGYSDPRYPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YND0</accession>
    <name>A0A1C3YND0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T15851</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YND0"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15851"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YND0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF24">
        <property type="entry name" value="TRANSPORT PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SCB65996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="510" mass="55089" checksum="2957AB3F74404A99" modified="2016-11-02" version="1">MSAKSGTIEKPKCPESLSDDAINININGAFEPVLRRDIKPLEIIALGFNVCNSWIAFSTSLAIAISAGGTVTVLYGILIVTLAYFAVSITLSELASVYPTAGGQYHFTSILCPDKSNRLVSYICGLAAVCSWTFLAASITILSSQLLLAVPAFYIETFVPQGWHYFLVFQAINLVLLLYNIFCLQRASWTHSIGFALSLVMFLIIFVTCLALSSKASSESVWTTFDNQTGWPAGVTFLTGLVTPASMYGGIDAVLHLAEECTSPERTVPRAMMAIVTIGCLTGFGFAVAMCYSITNLEALMTTTMPIYELWRQATGNNTAATVFDVMLHIITLFAVTAVQQTASRMTWAFARDGGLPGSSYLAVVNSKHQVPVWALVANSVVIFICGCIYLGSGAAFSAVIGSSLVLQIISFTIPALLLLWHKRSDSVLPRDGAFRVPDTVGWAANVLVVIFGIVFSVFFILPAAIPVTGNSMNYASAVIAICAICGSLNWVFYSKKRFVGPRIEQYRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1RA97</accession>
    <accession>A0A098D0B4</accession>
    <name>I1RA97_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG00424.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T01105</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316091.1">
        <property type="nucleotide sequence ID" value="XM_011317789.1"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CEF72354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="438" mass="47603" checksum="E3C17FB5B1B9E674" modified="2012-06-13" version="1">MASLQALWGPMARRLLRVAVAKTTNVVRTKFVVMTRPLQNQLTLRTARVARQPIHPVAALRQQKRHTSRWFSSSAAQNVNRVIRRFVSSEPKAARFDRSKLPSSSTSRRVAQFSGRAPFANALRPNLTGGAFPRSASGYSLGGSARYFSHGPAAPAQVVQNVSQAMRAFFLSGQKLRYDGLGPRGDRQYRAVSPVEDQAMHKLSAFSNSAPGAFVDFNISPTVTALSPLAAAIPFASETSGFKAEAAAAGASLNTEGFLDVLSSDFGRVLQDLRVIDTDLRRLAILGDLPVLLEKHNTLRVRFPGVDAETLERLCDDIGIQRGVVGQDPEFDDAAGVPVALKFPFAPDSGKQPSISLRSLEGYETDGISALDEEYFVYGDILDDMSDNPWLAETDGYETMSPPASSAIGQSEDYEGLEGIYRFLEECDQAKGKVGRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1RAS1</accession>
    <accession>A0A098D291</accession>
    <name>I1RAS1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG00606.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T01539</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316296.1">
        <property type="nucleotide sequence ID" value="XM_011317994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RAS1"/>
    <dbReference type="EnsemblFungi" id="CEF72570">
        <property type="protein sequence ID" value="CEF72570"/>
        <property type="gene ID" value="FGRRES_00606"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00606"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01539"/>
    <dbReference type="HOGENOM" id="CLU_1161226_0_0_1"/>
    <dbReference type="InParanoid" id="I1RAS1"/>
    <dbReference type="OrthoDB" id="5081952at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF72570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="239" mass="27139" checksum="27E033889D015219" modified="2012-06-13" version="1">MSRPKENQATVVAGRRQEECPKVATLCPAPRGEKETQHYSDGGSDSLVPQARDNAQYEIDESRQRQPSALKNVWRFFSTPQPSPYPQDRRGRTTRLDESQMQPYWNTPFRPESPMPPVSDSTIWPFSNDSEPEEVLDIEIIAWNRGPRRTVRIVHGDPRQAVQPAQAAIIVGPSTDDSSSAFEDESYEEEEEEDIVVQARRVTRVGRATLIKLPELNRNQNQNQDVQESRPPSVDLADC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I1RBL1</accession>
    <accession>A0A098D3H4</accession>
    <name>I1RBL1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T02361</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316678.1">
        <property type="nucleotide sequence ID" value="XM_011318376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RBL1"/>
    <dbReference type="EnsemblFungi" id="CEF72982">
        <property type="protein sequence ID" value="CEF72982"/>
        <property type="gene ID" value="FGRRES_00937"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00937"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02361"/>
    <dbReference type="eggNOG" id="ENOG502T4XH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1825456_0_0_1"/>
    <dbReference type="InParanoid" id="I1RBL1"/>
    <dbReference type="OrthoDB" id="5056676at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF72982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="141" mass="16540" checksum="A54A45D413F86FED" modified="2012-06-13" version="1">MPGEESQINAEIIAERMKTNLILEETLHSRLARDAPKGWEHLHPIIYDGQQEYHGFKKFPRYHANQRAYLVTREFRDGIYIATAIRNLSACSQREIVRLLEGIEDQGRDDIIYVANQGEEIPYYFESEDPDFIEWIGTRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1RBR2</accession>
    <name>I1RBR2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG00998.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T02501</name>
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    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316747.1">
        <property type="nucleotide sequence ID" value="XM_011318445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RBR2"/>
    <dbReference type="STRING" id="229533.I1RBR2"/>
    <dbReference type="EnsemblFungi" id="CEF73052">
        <property type="protein sequence ID" value="CEF73052"/>
        <property type="gene ID" value="FGRRES_00998"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00998"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02501"/>
    <dbReference type="eggNOG" id="ENOG502SBS6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142967_0_0_1"/>
    <dbReference type="InParanoid" id="I1RBR2"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039993">
        <property type="entry name" value="NDUFB10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE PDSW SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF73052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="127" mass="14631" checksum="9A45B0F8FE5BE577" modified="2012-06-13" version="1">MPTPESEQFKAQKPTVAPTFNGVDYDDTKAFKAAEDALIREQWVGAMMTRLVGEELNKCYVREGVNHLENCGHLRERYLQLLKSNKIKGTKFLQQNYIDQKEHDLDLAAKVHTSDKIAKMNRDRFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RCI2</accession>
    <name>I1RCI2_GIBZE</name>
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        <recommendedName>
            <fullName evidence="5">C2H2 type master regulator of conidiophore development brlA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG01298.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T03213</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317082.1">
        <property type="nucleotide sequence ID" value="XM_011318780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RCI2"/>
    <dbReference type="STRING" id="229533.I1RCI2"/>
    <dbReference type="EnsemblFungi" id="CEF73409">
        <property type="protein sequence ID" value="CEF73409"/>
        <property type="gene ID" value="FGRRES_01298"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01298"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03213"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056436_0_0_1"/>
    <dbReference type="InParanoid" id="I1RCI2"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="PHI-base" id="PHI:1350"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001075">
        <property type="entry name" value="Zinc finger, C2H2-type/integrase, DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="195"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF73409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="296" mass="32629" checksum="EB7BE9EB182BD2ED" modified="2012-06-13" version="1">MTMHAINAAGRRISLLNDESASQQPQPQQQRPPLSFHSSYAFNQSYPTPSSSSSSPNTPELLRSDSYDSQMSNDPVSPMTPNVDYYPRQQVIYTIPQDYNMDAKHVVYADSARSASYDAEMVSQPRSSPMPERPGKRYPCRYRDTHGCEKTFTTSGHASRHSKIHTAEKAVQCTFAGCQKKFTRADNMKQHLETHFKDKSRSSGSQRSHRTSLADARRNSTSGRPSASRTSSSRSRRDADPYPLPTPPLASPSISSGPWDMSGRNLPILNRPVTGRTPSGLDALAMAVACQEGSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1RDW5</accession>
    <name>I1RDW5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG01833.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T04433</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317675.1">
        <property type="nucleotide sequence ID" value="XM_011319373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RDW5"/>
    <dbReference type="EnsemblFungi" id="CEF74023">
        <property type="protein sequence ID" value="CEF74023"/>
        <property type="gene ID" value="FGRRES_01833"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01833"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04433"/>
    <dbReference type="eggNOG" id="ENOG502SHAY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_1_1"/>
    <dbReference type="InParanoid" id="I1RDW5"/>
    <dbReference type="OrthoDB" id="3923077at2759"/>
    <dbReference type="PHI-base" id="PHI:5816"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF21">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="28"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF74023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="347" mass="38395" checksum="D547D1E65BBEA062" modified="2012-06-13" version="1">MARVAGDGVALLWATIAMLSLSWIFATLRFGVRKWRKNLGLDDGLMLAGLILYTVTTSLVIRCCFYGSGQKRKDLEPNDIKMGTKLFFIAQFFYSACSVPIKSSICVTMLRICDSRRRFVWTLWGVIGITVFTALVFIIATANICHPIETLWGEANGKCNTKVNSSIGFYFSAVSILTDWTLAILPAILLWNIQMKQRVKLPVIVMLSLGAFASCATVVRLGYLTLYNDPTEFVYSTGAIGLWSILEEGIGIIAGSMPALRPLLSLPIFGRSTYASGGASNQASSHMNLGHMSNKRTQNQTDTELNDYHANLTTRISHSRDKQSLDDNDSQKFILKSTKVVMTTERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RE52</accession>
    <name>I1RE52_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable electron transfer flavoprotein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG01926.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T04649</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 10">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317777.1">
        <property type="nucleotide sequence ID" value="XM_011319475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RE52"/>
    <dbReference type="FunCoup" id="I1RE52">
        <property type="interactions" value="532"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RE52"/>
    <dbReference type="EnsemblFungi" id="CEF74131">
        <property type="protein sequence ID" value="CEF74131"/>
        <property type="gene ID" value="FGRRES_01926"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01926"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04649"/>
    <dbReference type="eggNOG" id="KOG3954">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034178_0_1_1"/>
    <dbReference type="InParanoid" id="I1RE52"/>
    <dbReference type="OrthoDB" id="1715808at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="11">
        <location>
            <begin position="35"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="262"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="276"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="293"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF74131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="347" mass="36047" checksum="DDF422E5D446BA8E" modified="2012-06-13" version="1">MLPNAKRVLAKQATGLMARAHAYSLGAQRQRLVSTLAVLEQKDGVLNHSSLSAFTAAKKLGGTVHGFIAGTGVKSVAQEVAKAEGVEKIIAVENAAYEKGLPETFAPLLVENIKKGGYTHVIAGHTAFGKNVMPRVAALLDSQQISDITAIESENVFVRPIYAGNAIATVESSDSVKIVTIRGTAFASVPLEGGSAAVEDGVDSKPESPTEWVSEDLAKSDRPDLSTASRVVSGGRGLKSKEDFDKIMLPLADALGAAVGASRAAVDSGYADNSLQVGQTGKVIAPELYMAVGISGAIQHLAGMKDSKVIAAINKDADAPIFQVADVGLVGDLFEKVPELTEKVKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1RE54</accession>
    <accession>A0A098D5A6</accession>
    <name>I1RE54_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG01928.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T04653</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317779.1">
        <property type="nucleotide sequence ID" value="XM_011319477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RE54"/>
    <dbReference type="STRING" id="229533.I1RE54"/>
    <dbReference type="EnsemblFungi" id="CEF74133">
        <property type="protein sequence ID" value="CEF74133"/>
        <property type="gene ID" value="FGRRES_01928"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01928"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04653"/>
    <dbReference type="eggNOG" id="ENOG502S9P8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018980_1_0_1"/>
    <dbReference type="InParanoid" id="I1RE54"/>
    <dbReference type="OrthoDB" id="5404940at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
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            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
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            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
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        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF74133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="590" mass="66106" checksum="2431F2DD8CFEB605" modified="2012-06-13" version="1">MPPSQAPFLYSAVHSDSRFPEPKFDPKAVTRASWTPPSPRKKQNGPLVSFNTHPDMHEVLTYRTNEYASMSPRSKSFIKWLRHGQLGLRVLQLVAALGLLALMLLIDKVPTLEGWVMRITPGVVAAHCIYGIYHLSRDAAGRSPASSASYQLFSGVTDIGVAPLYAFGAMTVRTKSEVWTTRLSDQALMDTFKPVLFYIFVSAGGLHLISLAIAGWLGFMFRKISLMPPDMNPLESHLTARPKHKRNKSSVMTASTFDSDHRVSSPRSARRESLVPQEGIHDGIEAPRVIPFSHTRNGSSTTVGTRDSRSRYPPSPQQQRPPTTPRRERRDSVTSRTTRTSATRSVYYDAYSEIPLDEQSTSRPSSSYNKYNQPRPAKFTETWKPTDSLISRTNQRNREMEAAKTSAANRQNKSYEALTQRYIHDDSDSEYGDENNQHYDLGVDGEDLRPHPLRLNPPSEKRERASPPRTKTPYFPFKDSLTDISSNARRVSASRDIADEKPAFTPQNRQSSIQPESAFYARSYGELTTGNSPVMVGSDSRKVSTGNDYNQHASPAYGRRNVSGKMVEEGRAAGNKFSFLDGRNPLAERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1REI2</accession>
    <name>I1REI2_GIBZE</name>
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        <submittedName>
            <fullName evidence="6">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG02071.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T04997</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317946.1">
        <property type="nucleotide sequence ID" value="XM_011319644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1REI2"/>
    <dbReference type="FunCoup" id="I1REI2">
        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1REI2"/>
    <dbReference type="EnsemblFungi" id="CEF74305">
        <property type="protein sequence ID" value="CEF74305"/>
        <property type="gene ID" value="FGRRES_02071"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02071"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04997"/>
    <dbReference type="eggNOG" id="KOG1505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041844_3_2_1"/>
    <dbReference type="InParanoid" id="I1REI2"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="143"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF74305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="420" mass="48114" checksum="8B1326434424B5F1" modified="2012-06-13" version="1">MADTTNADPSATAAPAPEILAGITEESLAKGENPLPKEEHPSGKDGYGTFMQIVRGSCFALYFNTCIVIIFLTQLIGLPLYFVNRDWYYAYVAMTKGFFGLTITLMTQIWGPTTIRVSGDESVAGQIKLRSDGGVQFEFPERLVLIANHQIYTDWLYLWWIAYANSPSMHGHIYIILKESLRRIPIVGLGMQIYGFIFMSRKMASDQPRMAYRLNKLKQPKVDPNGKSYMNPMWLLLFPEGTNLSNNGRRKSAGWAAKMDLKDPEHVLLPRSTGMFFCLNELKGSLDYVYDCTVAYEGIPRGGFGEQYFGLVSTYFQGRPPKSVNFHWRRFRLSDIPLDDQKAFDLWLREEWYKKNALMEEYMTTGRFPRMEGGKVDYIETEVKTRQPWEILQLFTVVGTAALIWHNVKKTFTTVTTVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1REN0</accession>
    <accession>A0A098D5Z1</accession>
    <name>I1REN0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG02123.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T05117</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318001.1">
        <property type="nucleotide sequence ID" value="XM_011319699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1REN0"/>
    <dbReference type="EnsemblFungi" id="CEF74364">
        <property type="protein sequence ID" value="CEF74364"/>
        <property type="gene ID" value="FGRRES_02123"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02123"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05117"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1428108_0_0_1"/>
    <dbReference type="InParanoid" id="I1REN0"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF74364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="190" mass="20446" checksum="7119DEA6B3E99E88" modified="2012-06-13" version="1">MSAAEHQGAGAQKASQEGTRELGVAGIDASSGSAASSDYTQNRVYWMVGPIMCTIVVGSSILTAWPPSDAARVAGFFLAASGYVTGIMWTWANEINVGNAEERAMTISSMNGFFYATTSFMPILIFPQTMAPKFERGFPTVLSFAVGACGLILFANFLHQRQLRMEAKATSRELPVEVPESDVDENEKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1REU4</accession>
    <name>I1REU4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG02195.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T05287</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318082.1">
        <property type="nucleotide sequence ID" value="XM_011319780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1REU4"/>
    <dbReference type="EnsemblFungi" id="CEF74448">
        <property type="protein sequence ID" value="CEF74448"/>
        <property type="gene ID" value="FGRRES_02195"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02195"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05287"/>
    <dbReference type="eggNOG" id="ENOG502RJAS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1825389_0_0_1"/>
    <dbReference type="InParanoid" id="I1REU4"/>
    <dbReference type="OrthoDB" id="4985370at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
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    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="26"/>
            <end position="74"/>
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    </feature>
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            <begin position="38"/>
            <end position="74"/>
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    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF74448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="141" mass="15765" checksum="E213FCC06D495027" modified="2012-06-13" version="1">MANTNTKNPHVSRLRPWQRRALENGRTPLPEAQGDQRWLSSPCHSQQPAGSFTQGATSTTPAGESSGKASTNVATPSFSYRFWPEDEMRHLIALRNGGATWAMIYTEFPNRTHEAIKQAYHKRRHAIEQQMENEATGATSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1RF11</accession>
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        <submittedName>
            <fullName evidence="9">Chromosome 1, complete genome</fullName>
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        <name evidence="10" type="primary">FG02274.1</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318180.1">
        <property type="nucleotide sequence ID" value="XM_011319878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RF11"/>
    <dbReference type="EnsemblFungi" id="CEF74548">
        <property type="protein sequence ID" value="CEF74548"/>
        <property type="gene ID" value="FGRRES_02274"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02274"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05487"/>
    <dbReference type="eggNOG" id="ENOG502SAPN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070115_0_0_1"/>
    <dbReference type="InParanoid" id="I1RF11"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="PHI-base" id="PHI:5874"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF92">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="25"/>
            <end position="257"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20684"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF74548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="341" mass="37848" checksum="279F0A426CEF0661" modified="2012-06-13" version="1">MISSTAVMAFEWTILVLAYFLVACRVYVRMFIRGVGLHAADYWLIVGLVSCQGLLICDTLTFRMHAMDDFVLANNSIPIKKIRFATNYFFDTGIYFPKFSIIAFYFNLVPITNPPMRRALFGLTGITVAFALITVFCDTFWCGPNPSVNWAEGEQTCTVFTSMTLMRLNWALNFITEVLNLVFPIPLLQGLMTSTRKKIGLAVVFGMGIITIAVSIGRFVTMLYVHNDISIYIWATAEICISVMIVALTALRPLLRKMTNSVSTSSDDRSGNPSRKTGLTRNSVYWPGGNKIPRRHVVEVGSESLAGSETELNTMNRGIMMTKQVTVSVGNAESDVGSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
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        <name evidence="8" type="primary">FG02540.1</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Hypocreomycetidae</taxon>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_011320175.1"/>
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        <property type="gene ID" value="FGRRES_02540"/>
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    <dbReference type="eggNOG" id="KOG0387">
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:nucleus"/>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
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        <location>
            <begin position="410"/>
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    <feature type="domain" description="Helicase C-terminal" evidence="6">
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            <begin position="739"/>
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    <sequence length="1163" mass="130333" checksum="40665A6A71EA09CB" modified="2012-06-13" version="1">MAAQDAGSENHEVDKAALLDQMVAAAQESVSQNEGQEEQPNTEGLNEEDALRNLTGTVRDQNDLERDITLQANAALNEAEDKKDKNRIAKLQESKHRLQLQLDKEKKNLERVAHSNVYQSRNIQKKIAKLDDEIRQMTSDISDFQSRISKRHEDHPAEDPKKSKSAKLPGETNREFLIRTGKITPFAKIGGPRPAGIQGQLAETILDAEEEAAAEQLGEELQGPASHQQLRRPGFADEIETETAPPQPAATIAESEFSLRPRKKTRLTQKERSPSADFEPEASGNESHDDDVWQQGNEDDLIREQRRQAKAKAKVADQEQIDLSKIDDGNESHYKTRLNDWVTRRSRARKARRLTSEVPTDGNESDEEEKEWFKPAPDFPDYDFGDGLKLPGDIHPSLFGYQKTGVQWLAELYKQNVGGIIGDEMGLGKTVQLIAFIAALHYSKKLRRPVIVVAPATLLRQWVSEFHRWWPPLRVSILHASGSGMMNPKFEDEYDLDHYKPLATKSQKAASRIVNGVAKSGHVLVTTYTGLQTYADTLLPVEWDYAVLDEGHKIRNPNAEITVTCKELNTPNRVILSGTPVQNNLTELWSLFDFIYPMRLGTLVNFRAQFEIPIRQGGYANASNLQVMTAEKCAEALKETIGEYLLQRLKVDVAADLPEKTEQVLFCKLTEGQHKAYETFIKSDEVSAILNRRRQSLYGIDILRKICNHPDLLDKSLGKKAGYDFGNPKLSAKLQLTKDLLQKVMIPNGHKTLLFSQGKQMLDIIEKCIGECGISYVRMDGETPVDRRQTMIDKFNESPDIHVFLMTTRTGGLGTNLTGADRIIIFDPDWNPSTDLQARERAWRLGQKKPVKIYRLMTEGTIEEKIYHRQIFKQFMTNKVLKDPKQRSSYDLSDLYDLFSFNTGKDATANRSEIFKKAQVSLTNGDEDGNGNLDPKHVGSPDREKDKERMELKQMGLVAAMEDVREEKSSHDEKRMLEGIFAKSVNNAYDHEAIVNGPQKPKADISILQDEANLVARQAAAHLRQAGAEARRVPIGTVTWTGEVGQAGRPGANRRRGGPSSAGIMSNLADRQGLDTGSGRSSRSGTPGVDKNLKSKDFIAMIKTFINRHNGRVPSKMLVDHFNPYCPGKKQSDEFKAALDKVAVMNKTGGAGRGIWTLKPGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>I1RFQ7</accession>
    <name>I1RFQ7_GIBZE</name>
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        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="4">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 93 kDa subunit homolog</fullName>
            <shortName evidence="4">eIF3 p93</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Translation initiation factor eIF3, p93 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG02544.1</name>
        <name evidence="4" type="synonym">NIP1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T06107</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
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                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit C family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="FGRRES_02544"/>
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    <dbReference type="eggNOG" id="KOG1076">
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        <property type="component" value="Chromosome 1"/>
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        <property type="entry name" value="PCI_dom"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="600"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="796"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
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            <begin position="40"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <begin position="802"/>
            <end position="811"/>
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    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
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            <begin position="823"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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            <begin position="836"/>
            <end position="846"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="859" mass="96594" checksum="068CF61D88E4984A" modified="2012-06-13" version="1">MSRFFRGGDDSSSDSSSEEEELYSEEEEEEEQQDSQAESSENDDSDDSDSDDEGGKGINKFLKDASSDSDDSDDEVRAKVKSAKDKRLDELESSIKQIENGQKNGDWTLIAAEYEKLNRQVAKMPGSRPPKPYIRILAELEDFMNESLAKQKVTPKKMNAIQNRSLNAVKQKVKKTNKEYQSQIDAYRADKDAFMDSSDNEPVVPTVSKPKKVSLQVDAAPAAEGDDDGFATVGKGGRTLQYTPESIFKHLRTIMESRGKKNTDRTEQIKTMEKLSEIANTPYQKIRVLLTLVSTRFDIGSGGASAMTVENWKAAEKELSSLLQVLEENHDYVVVENAEEWDDDEKPPTLQEGEKHIKVPGSIVSYIERLDDELVRSLQSIDPHTSEYIERLQDEGSLYNIIFRGLLYYEYLRKDDSLEIPQDSINRIVMRRLEHVYFKPAQVVQTFEENCWKPVGDSVESVITPRDQAQNAGNLVNVLCNYLFSNSEGIIRARAMLCQIYFLALHGEYYKARDMMLMSHLQENIPNFDVQSQILYNRTLVQVGLCAFRKGLVYEAQNTLQEICGSGRQKELLAQGVMMQRYNQVSPEQERLEKQRQLPFHMHINLELLECVYLTCSMLLEIPLLAQTGSSPDVKKRVISKTYRRMLEYHERQIFTGPPENTRDHVMQASKALAAGEWKKSTDFIHSIKIWELMPGAEEIKAMLSKQIQEEGLRTYLFTYAPFYDTLSTETLSAMFELDSAKVAAVISKMISHEELAASLDQVTSTVIFRKGVELSRLQSLALALSDKASALIESNERTLEQKTQGTSNAFERQGGRGRGGRGRGGGQGRGGARAGGNTQRQAGGTQFTGGALGAAVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RFT2</accession>
    <name>I1RFT2_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG02571.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T06161</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318509.1">
        <property type="nucleotide sequence ID" value="XM_011320207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RFT2"/>
    <dbReference type="STRING" id="229533.I1RFT2"/>
    <dbReference type="EnsemblFungi" id="CEF74885">
        <property type="protein sequence ID" value="CEF74885"/>
        <property type="gene ID" value="FGRRES_02571"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02571"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06161"/>
    <dbReference type="eggNOG" id="KOG3677">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029210_2_0_1"/>
    <dbReference type="InParanoid" id="I1RFT2"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="257"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF74885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="476" mass="54978" checksum="6928221494A5B5D2" modified="2012-06-13" version="1">MATYQNGVAPARAMDDDSDVEEEALVAEYKEQVQYEDGDDLSRTTSLNLAQQTDDIQSRLVQAAQPLDFQAPLEAKFQSYDAYCSLFHFILNSEGPVDLEPPSYYWAWDVIDEFIYQFNSFSSYRMRIARQTTNEEERQALRENPNTWGCYSVLNVLYSLIQRSQITEQLGAMKRGEDPAAVAGEYGNKNLYKMLGYFSIIGLLRVHCLLGDFSLALKTLDDIELNKKAMFARVMAAHFTTYYYVGFSYMMQHRYADAIRMFSHILIYVSRTKNFQKSAQYDSITKKNEQMYALIAICVAFQPTRLDDTIHSALREKYGDQLLKLQRGGPESLPIFEELFRAACPKFISPVPPDFENPEANIDPVEHHLAVFMDEVKTNMWSPTIKSYLRLYTTMDLNKLAGFLEVKPEELRSWLLVTKQRTKQLRWQDQGLLDGELVNVSDLDYALQGDLIHISEAKVGRKLVDWYLRNLSRTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1RFT4</accession>
    <name>I1RFT4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG02573.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T06165</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318511.1">
        <property type="nucleotide sequence ID" value="XM_011320209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RFT4"/>
    <dbReference type="STRING" id="229533.I1RFT4"/>
    <dbReference type="EnsemblFungi" id="CEF74887">
        <property type="protein sequence ID" value="CEF74887"/>
        <property type="gene ID" value="FGRRES_02573"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02573"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06165"/>
    <dbReference type="eggNOG" id="KOG2417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039213_0_0_1"/>
    <dbReference type="InParanoid" id="I1RFT4"/>
    <dbReference type="OrthoDB" id="264392at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="508"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Golgi pH regulator conserved" evidence="7">
        <location>
            <begin position="207"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Abscisic acid G-protein coupled receptor-like" evidence="6">
        <location>
            <begin position="348"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF74887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="546" mass="59135" checksum="58E9F43494F45729" modified="2012-06-13" version="1">MWPFTRCGEDACEIPPRPVTLASSISALPFLFICISTSILVVRHVFPRLSTDADSRDGEDHVLPTHAPACLRQVHAEHGAKSWRRRGAAWTFGLTVGLAATLGALIMDEIIEVVNADSRNLALRITVPSLLFLLVVLVPWLECRSVVTSAGWSFQRTAKGKLPRFAWGLHAALFMGWLFAFWSVGQAVPEGAMRRMSNGSGSLSDMLTRGCLERIGVVGISLMALLSGFAAVSSPWHALMDLTARRKRPVTDTDVARKQAGWDTANEMLLTKRHRLQFLERKTSAAQTGASAKGSGLVGKVMGSLRGATGDEAEIRLLRLEIAGLETMEANLASGVSLLKSHRAATVRASTPLGRLFLVPSQLFSLYCLYRIGATTITTIRRAYSPTSSFANTDPINRFLSILARHWDPKLDQLAWARLISFALSGVILVASANSVVQTFHLFAKWTPGLLRQAQANLALVVGQIAATYVISAALLLRSQLPSALGSAVGSVLRGALSPAFVDGWFEGWFLVGSLVTAIGIWVGRKLGGEDEWDEYGMEEVGAKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>I1RG11</accession>
    <name>I1RG11_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">FG02659.1</name>
        <name evidence="23" type="ORF">FGRAMPH1_01T06377</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="24">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="24 25" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="25">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="24">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="23 25" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="23">PH-1</strain>
        </source>
    </reference>
    <reference evidence="24" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318610.1">
        <property type="nucleotide sequence ID" value="XM_011320308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RG11"/>
    <dbReference type="SMR" id="I1RG11"/>
    <dbReference type="FunCoup" id="I1RG11">
        <property type="interactions" value="1223"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RG11"/>
    <dbReference type="EnsemblFungi" id="CEF74993">
        <property type="protein sequence ID" value="CEF74993"/>
        <property type="gene ID" value="FGRRES_02659"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02659"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06377"/>
    <dbReference type="eggNOG" id="KOG0214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_5_1_1"/>
    <dbReference type="InParanoid" id="I1RG11"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140727">
        <property type="term" value="P:siRNA-mediated pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="19">
        <location>
            <begin position="36"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="285"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="503"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="602"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="704"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="16">
        <location>
            <begin position="795"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="1169"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="736"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CEF74993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1269" mass="143761" checksum="74ED6C60FE794E1B" modified="2012-06-13" version="1">MDDSYENDSDYDYGYDEGITPEDCWTVISSFFETKGLASQQTDSFDEFTQRTVQDLVNEYADISLDQQNPPSSYGVPIALRRYEIKFGSVMVSRPSISETDGTVASLLPYECRDRNLTYSSPAYIKITKKVSVAYDKEIPLHEMDEEQQAEYKRTGEHPTKLHWEVEEDGDSMKEGQPNMIFVGKMPIMVKSKICHLSQHTDEELFTLNECPYDQGGYFVINGSEKVLIAQERSAANIVQVFKKAQPSPFTYTAEIRSALEKGSRLISSLMMKILGKGDSARGGFGQTIQTSLPFVKSDLPVAIVFRALGVVSDEDILNHICYDRNDSQMLEMLRPCIEEAFCVQDREVALDFIGKRGNRDQASLGREKRVRVAKDILQKETLPHISQSEGSETRKAFFLGYMVHKLLQCALGRREPDDRDHFGKKRLDLAGPLLAKLFRGIIRRMNQELSNYLKRCVESNRNFNLNVAIKPGTLSNGLKYSLATGNWGDQKKAASSTAGVSQVLNRYTFASTLSHLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLMCYVSVGSPGEPLIDFMVSRGMEVVEEYEPTRYPHATKVFVNGSWVGVHPEPRALVNSVLETRRKSYLQFEVSLVRDIRDREFKIFSDAGRVMRPVFTVQQEDDYETGLTKGQLVLTKDLVNKIAQEQAEPPSDPSERIGWQGLIRSGAVEYIDAEEEETAMICMTPEDLEIYREQKRDEVNLTEEEKQAKLEAEKREQEEERNKRLKTKVNPTTHMYTHCEIHPSMILGICASIIPFPDHNQSPRNTYQSAMGKQAMGFFLTNYSRRMDTMANILYYPQKPLATTRSMEFLKFRELPAGQNAIVAIACYSGYNQEDSVIMNQSSIDRGLFRSLFFRSYSDQEKKVGLNYTEIFEKPFQQTTLRMKHGTYDKLDEDGIVAPGVRVSGEDIIIGKTAPIDQENQDLGTRTQTHQRRDISTPLRSTENGIVDQVILTVNADNVKYVKVRVRTTKIPQIGDKFASRHGQKGTIGVTYRQEDMPFSREGLTPDIIINPHAIPSRMTIAHLIECLLSKVSTLEGMEGDATPFTDVTVDSVSDILRKHGYQSRGFEVMYNGHTGRKLRAQVFFGPTYYQRLRHMVDDKIHARARGPVQIMTRQPVEGRARDGGLRFGEMERDCMIAHGAAAFLKERLFEVSDAFRVHVCEICGLMTPIANLSKQSFECRPCKNKTKIAQIHIPYAAKLLFQELQAMNIAARMFTNRSGVSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I1RIA8</accession>
    <name>I1RIA8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG03539.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T13115</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322170.1">
        <property type="nucleotide sequence ID" value="XM_011323868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RIA8"/>
    <dbReference type="EnsemblFungi" id="CEF78361">
        <property type="protein sequence ID" value="CEF78361"/>
        <property type="gene ID" value="FGRRES_03539"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03539"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13115"/>
    <dbReference type="HOGENOM" id="CLU_3242246_0_0_1"/>
    <dbReference type="InParanoid" id="I1RIA8"/>
    <dbReference type="OrthoDB" id="10441414at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013265">
        <property type="entry name" value="TRI9_FUSspp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08195">
        <property type="entry name" value="TRI9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF78361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="43" mass="4582" checksum="150738D191930659" modified="2012-06-13" version="1">MLAAAKLIDSYEMDPDVSWLEVFAYSGVSAALCATIWVAAKAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJS9</accession>
    <name>I1RJS9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG04111.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T14517</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321525.1">
        <property type="nucleotide sequence ID" value="XM_011323223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJS9"/>
    <dbReference type="FunCoup" id="I1RJS9">
        <property type="interactions" value="253"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RJS9"/>
    <dbReference type="EnsemblFungi" id="CEF79062">
        <property type="protein sequence ID" value="CEF79062"/>
        <property type="gene ID" value="FGRRES_04111"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04111"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14517"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013173_9_1_1"/>
    <dbReference type="InParanoid" id="I1RJS9"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="PHI-base" id="PHI:2326"/>
    <dbReference type="PHI-base" id="PHI:2491"/>
    <dbReference type="PHI-base" id="PHI:5720"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="143"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="525"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF79062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="577" mass="61352" checksum="B351E233F1E35086" modified="2012-06-13" version="1">MFGGSSNNSAGNKSESDSKSDKSPSPEPGTGLSAPSPIKTTDQAASGEKRSGNGSPPTRQDVGGPSDKKRRSSSVSSRASSLLASAKNSLNFSSQSSRGGGSEVNSQTSLQKLGKQDPALAVPQGQHNNSAGDSMPGPKSTFRVGVWEDRNKKCRRTMEDTHAFLYNFVQTPALNDASAKDKPEGDDLVTSDMVESDNGYFAIFDGHAGTFAADWCGKKLHIILEDIIRKNPNALIPEVLDQAFTAADAQLEKLPLKNSGCTAAVAVLRWEDRASNDRSAIKPVKPEEPIEMDKANDGSSNEEATKATNSKGKGSGRQRVLYTANVGDARIILCRGGKALRLSYDHKGSDEVEGKRIAAAGGLILNNRVNGVLAVTRALGDAYMKKLVTGHPYTTETVIQPDSDEFIIIACDGIWDVCSDQEAVDLVRNVNDPISASKQLVDYALNRFSTDNLSCMVVRLDQNKEAAVEVEGAASQVSEADKIVSETKQKIAEGIAPAVGVSATSNAPQSQPPIAVQEGDFVPTSLDDIVTEEPPHVADPKSDDVPILNKAAVLEARKDKPAEEKPVEEQETPPGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJW4</accession>
    <name>I1RJW4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG04147.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T14603</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321483.1">
        <property type="nucleotide sequence ID" value="XM_011323181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJW4"/>
    <dbReference type="STRING" id="229533.I1RJW4"/>
    <dbReference type="EnsemblFungi" id="CEF79104">
        <property type="protein sequence ID" value="CEF79104"/>
        <property type="gene ID" value="FGRRES_04147"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04147"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14603"/>
    <dbReference type="eggNOG" id="ENOG502RS5R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053579_1_0_1"/>
    <dbReference type="InParanoid" id="I1RJW4"/>
    <dbReference type="OrthoDB" id="4579506at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF79104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="207" mass="23351" checksum="CB466114F87868CE" modified="2012-06-13" version="1">MPNTPPPALLPPPEGIFRTFDDLMASVQRVAKDQGYGIVKLRASNYRDGKPTRYDLVCDRGGVKYNSTAKKRNPSTRKIDCPFRAKAVCEVQLGNQWRFAIQEGRHNHEPRVPAGTPGQENAPLATSIRSFTNKLDRLSHDMAQGLMRIEQRLDNIEKRMENLEARAGGYEPRFQAIEQRLQGIEGPRMDGMGMDDVEQRLLASTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJX2</accession>
    <name>I1RJX2_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG04155.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T14621</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321475.1">
        <property type="nucleotide sequence ID" value="XM_011323173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJX2"/>
    <dbReference type="STRING" id="229533.I1RJX2"/>
    <dbReference type="EnsemblFungi" id="CEF79113">
        <property type="protein sequence ID" value="CEF79113"/>
        <property type="gene ID" value="FGRRES_04155"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04155"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14621"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_2_1_1"/>
    <dbReference type="InParanoid" id="I1RJX2"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000049">
        <property type="entry name" value="Putative uracil phosphoribosyltransferase urg2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF4">
        <property type="entry name" value="URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="10"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF79113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="224" mass="23882" checksum="1B762C324358F6ED" modified="2012-06-13" version="1">MSSLPSNVHVSQHPCLVAKLSQLRSKSISPREVKSLIHEVSLIVSCEAFASSLKATEGSQDETPLGFQFKSTTVSPSTMCLVPILRSGLGMVDAVQTMLPVAVPVHHLGMYREPSTLDPVEYYNNLPQQSSSEKASSLAILVDPVIATGGTCAAAIQTLREWGAERILVLSVIGAKEGVQRVAAEWPEGCEVWIAGVDNELTSDGMLKPGLGDVGDRLFLTIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1RKT2</accession>
    <accession>A0A098DM70</accession>
    <name>I1RKT2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG04499.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T15451</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321094.1">
        <property type="nucleotide sequence ID" value="XM_011322792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RKT2"/>
    <dbReference type="EnsemblFungi" id="CEF79527">
        <property type="protein sequence ID" value="CEF79527"/>
        <property type="gene ID" value="FGRRES_04499"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04499"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15451"/>
    <dbReference type="eggNOG" id="ENOG502S3P0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061751_1_0_1"/>
    <dbReference type="InParanoid" id="I1RKT2"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="123"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF79527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="360" mass="40612" checksum="226736F3CEBCC232" modified="2012-06-13" version="1">MIASDIHPLPTTPDQVTVSWLSKVLGHNIKSAELTQSILNATASKLFFTIEYQDDNNNADRPKNVCLKGGFNPAMMAVEGYKDMLIAAYTNEARFFSLVALNLSHISLPKIWWTGVEEEQGILVMEDLNHSGFTFGNPQEVWPVERLKAGVEQLAALHASTWGYSSEKYPWITPSYEGMIMGLTEMWDDQILGADRPPCPDVIKKSQERTVSAIKKHFATKNPKFICLIHGDPHTGNTYSNKAGNPRFLDWQTFHIGSPFHDLTYFIVGALSVEGRRTHEMTIVDHYLDTLARFGGPSLSTKDDEVMREYSKSMMSGMGWILTPYTFQPKERVFAMCERYGAAIVDHKAIEIAESWSDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RLF1</accession>
    <name>I1RLF1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T16221</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323188.1">
        <property type="nucleotide sequence ID" value="XM_011324886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RLF1"/>
    <dbReference type="FunCoup" id="I1RLF1">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RLF1"/>
    <dbReference type="EnsemblFungi" id="CEF87700">
        <property type="protein sequence ID" value="CEF87700"/>
        <property type="gene ID" value="FGRRES_04747"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04747"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16221"/>
    <dbReference type="eggNOG" id="ENOG502RX7Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019313_1_0_1"/>
    <dbReference type="InParanoid" id="I1RLF1"/>
    <dbReference type="OrthoDB" id="3251668at2759"/>
    <dbReference type="PHI-base" id="PHI:1980"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF20">
        <property type="entry name" value="PRO1A C6 ZINK-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF87700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="595" mass="66320" checksum="84B7F19DD98EF3C5" modified="2012-06-13" version="1">MKTSICWTCRLRHKKCDETLPICGACAALEIDCHYSPRKPQWLQTEERRLEALARLKAQVKRSAKRRRGISQMRSIANDIDSSPDLSTFEPCPGTSQDSLTQETMVEPSSEPVTPPTITPTTDRAAYISVYMDYIFPILFPFYRPYVTQGGRVWLLSLAMNNAGFMSSITSIFSLVLWLVPAHVGPGQADCASQTLEDFHAQASVALGSMQHDLQHLHQRGIENCLTDSVYLLANMMQQLSFELIIAPSGNWQTHLDAATSLFEQILEHHGRDGPTRQLSTVISNLSRRPWPGAANALNAKQGTFSFFSSILLFADIISSTVLDQPAKLLEYHCELRQCNAQQKPHIALEEITGCHTWVLLTISDISNLSRWKKDQITSGKLSNDELIYRATSLERILNNGLDTLDQSGNTNNSQQIPPLELLLNQSGSPFSFSKAAPDGRLPLTRTWIYAARTYLHSVKLDSSTDSSELEICVKQTIQSFGTITSSPWMRWLAWPLCVAGIYANMGGDMQWGEFGDVAELAKGYCLDGTVKPLFAMESYTGEAMSLFELSGKHYLYNAIEGSLYQVNQPNDLQSIVSTIDDPEKCLSELEIEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1RN63</accession>
    <name>I1RN63_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="6">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG05428.1</name>
        <name evidence="6" type="synonym">TIF6</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T17893</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <text evidence="6">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323965.1">
        <property type="nucleotide sequence ID" value="XM_011325663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RN63"/>
    <dbReference type="FunCoup" id="I1RN63">
        <property type="interactions" value="1092"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RN63"/>
    <dbReference type="EnsemblFungi" id="CEF88731">
        <property type="protein sequence ID" value="CEF88731"/>
        <property type="gene ID" value="FGRRES_05428"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05428"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17893"/>
    <dbReference type="eggNOG" id="KOG3185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071894_0_0_1"/>
    <dbReference type="InParanoid" id="I1RN63"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:nucleolus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="6">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="6">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF88731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="246" mass="26567" checksum="BFE02E0DFC8AF7B8" modified="2012-06-13" version="1">MAVRAQFENSNEVGVFATLTNSYALVALGASENFYSVFEAELQDIVPTVRTTIAGTRIIGRLTAGNRKGLLVPTTTTDQELQHLRNSLPDSVRIQRIEERLSALGNVIVTNDHIALVHPDLERETEEIIADVLGVEVFRQTVADNVLVGSYMSLSNQGGLVHPKTPIQDQDELSSLLQVPLVAGSVNRGSNVVGAGMVVNDWLAVTGLDTTATELSVIESVFRLGEGQGPSNINTSMKDTMVESFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I1RNB8</accession>
    <name>I1RNB8_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG05488.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T18045</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324033.1">
        <property type="nucleotide sequence ID" value="XM_011325731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RNB8"/>
    <dbReference type="SMR" id="I1RNB8"/>
    <dbReference type="FunCoup" id="I1RNB8">
        <property type="interactions" value="796"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RNB8"/>
    <dbReference type="EnsemblFungi" id="CEF86131">
        <property type="protein sequence ID" value="CEF86131"/>
        <property type="gene ID" value="FGRRES_05488"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05488"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18045"/>
    <dbReference type="eggNOG" id="KOG0121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070952_1_1_1"/>
    <dbReference type="InParanoid" id="I1RNB8"/>
    <dbReference type="OrthoDB" id="201398at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000399">
        <property type="entry name" value="Nuclear cap-binding protein subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="48"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="129"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF86131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="173" mass="20000" checksum="3B3A7DD3A01AE7E0" modified="2012-06-13" version="1">MRPGVRSTVERLDRPSAYYQNRNKRRRDRDDESNQPQEPQVDPLANATTLYVGNLSFYTTEEQVYELFAKCGEIKRLVMGLDRFNKTPCGFCFVEYFTHQDALDCLKYIGGTKLDERIIRTDLDPGFEEGRQYGRGKSGGQVRDEYREDFDEGRGGVGRAIQAEERDEYAEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQ61</accession>
    <name>I1RQ61_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="7">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG06198.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T19735</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="7"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324840.1">
        <property type="nucleotide sequence ID" value="XM_011326538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQ61"/>
    <dbReference type="FunCoup" id="I1RQ61">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RQ61"/>
    <dbReference type="EnsemblFungi" id="CEF86325">
        <property type="protein sequence ID" value="CEF86325"/>
        <property type="gene ID" value="FGRRES_06198"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06198"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19735"/>
    <dbReference type="eggNOG" id="KOG2381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009049_2_0_1"/>
    <dbReference type="InParanoid" id="I1RQ61"/>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="162"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="308"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="592"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="659"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF86325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="782" mass="88113" checksum="A32068A7DA5DB7CF" modified="2012-06-13" version="1">MPRSRPATTGYERLAQADDFSDDSDEDPLAQSYASLQPAAAPRYGPVSQPRHRSGMASPKSLTSSSQPKFRHRSGSSAGVDLKAINARLERWADEIASRFKRKGKNQQGEEERLEIHYSVFQPPEGIRPVTAESTAVPHEGVMSKAEFETIVESVRSAIRQEVHPSMISQGSSGSYFARNPDGKIVGVFKPKDEEPYAAGNPKWNKWIHRNLFPCCFGRACLIPNLSYVSEAAAYVLDCQLRTHLVPYTDVVWLASKSFHYPFWDRRKFHRKKTPLPAKPGSFQVFLKGFKDANVFLREHPWPDQYWSGFRTNDNQNKKKKRWTESCRPSGNATPNDGYNSDDEEAAQGANLLGPDNFIWTENLKESLREELEKLVILDYIMRNTDRGLDNWMIKVDWETGKASIASDPIQLNMEPVAEEEGPRPVDLSQQGPRATRASYPYKTQRPMSASSRKHVGNEPAITVGAIDNSLSWPWKHPDAWRSFPFGWLFLPVDLIGRPFSQKTRDHFLPLLTSTSWWTQTVLSLKRVFQMDCDFQERMFAKQVAVMKGQAWNVVETLKTPDHGPLELTRRARVCVWDDLVDVPVAVPMRNTSSEVRRNPHVRQSMDEADIASSAPASNPPIEDLLGLASAPADMPHPGRFELSSPTEETAPSLGEQPSGETNFLASTGLQQHSGDVTERPAARPAGVRNSYQGPVRALNMYEPARQHTSRQQRRYSFANAAARHNSNSIAQQYYGDTEHYTDDLEGDLGYAAAEGQMGNQRKVIVERLEAVKSRNPVFECW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQX2</accession>
    <name>I1RQX2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T22363</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326074.1">
        <property type="nucleotide sequence ID" value="XM_011327772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQX2"/>
    <dbReference type="FunCoup" id="I1RQX2">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06473"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22363"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_5_0_1"/>
    <dbReference type="InParanoid" id="I1RQX2"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF23">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SCB65058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="527" mass="56236" checksum="CA1B19FF62E2B8FD" modified="2012-06-13" version="1">MSKHDSGSTSTGAMEQPAIDQKPRRNSKASGSGNPDAADQLLENLGYKAELSRNRSTFQVAFMSFVLASIPYGLATTLAYPLIGGGPVNVIWGWLAVSLIIVCVAASLGEITSVYPTAGGVYYQAFMLSPPRWRRIASWICGWLYIVGNITITLAVNFGTALFIVSCVNVFESSPGVGVMSGEAYQVFLVFLGLTFLCNAISALGNKYLPWIDTAAVFWTFAGVIAIVVCVLAMAKEGRRDAAYVFGHFEANSGWPKGWSFCVGLLHAAYATSSTGMIISMCEEVQNPSVQVPKAMVATIFINTFAGLLFIIPLMFVLPDLQQVILSAQPVPFIIKSAVGSSGGAFGLLFPLIILAIICGIGCTTATSRCTWAFARDGAIPGAKWWSKVNTSLDVPLNAMMLSMVVQIILGVIYFGSSAAFNAFSGVGVICLTASYATPIAISLATGRKQVKTGKFYLGKFGAVANVIAIAWSLLAMPLFCMPSMIPVTPETVNYAPVVFVFACLVSGIWYWAWGHKNYAGPPTNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1RR15</accession>
    <accession>A0A098DUF8</accession>
    <name>I1RR15_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG06519.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T22489</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_011327827.1"/>
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    <dbReference type="AlphaFoldDB" id="I1RR15"/>
    <dbReference type="STRING" id="229533.I1RR15"/>
    <dbReference type="EnsemblFungi" id="CEF84989">
        <property type="protein sequence ID" value="CEF84989"/>
        <property type="gene ID" value="FGRRES_06519"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22489"/>
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            <end position="101"/>
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    </feature>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1RTB7</accession>
    <name>I1RTB7_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
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        <name evidence="4" type="primary">FG07418.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T24773</name>
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    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_011328886.1"/>
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        <property type="gene ID" value="FGRRES_07418"/>
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    <dbReference type="KEGG" id="fgr:FGSG_07418"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF84370"/>
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        </source>
    </evidence>
    <sequence length="618" mass="68389" checksum="9BFC8C44F6EB2905" modified="2012-06-13" version="1">MIPNASISRLPISRKTYILTLVLSLFLCAFGNAHASELLHDSIFDAETHIERSDASNLIYEPDFGAFDRSILGRAPAEQSLLTNNGPDSRKLSPGATVCYVVDKKTLFGKDKRDDDGHEPRNAEDDPGHQNFRRAESKTVYISVNTCSRPTMKSKDKDNNPETAPQLSLYTSMSSKIKCPDSSNYNKTNSDLKRIPFDEGAAMVTVNATDAIYISVAAPNITKKHDGDWEYQIAISFDEYYHNYDSQNGTARLLLMDTDSTSALLVTSNLTEDSSETQQIMKRPPPYQLFVGDEKLRSIDGLRHSACGLKQSAEIWANSNRTGRHNDLVTTGVTTRGPGQLPKQQFLIAGLNHSSSYLGILVKMPEGNGKRAETTGGGGTVYRATSFETSSSSNCKMVTNLDFCNETQYAVPGNDKKFNNTALAKHYDDYARKMYANFEKVMMQMPCETTPESLYSLVRNCDECRAAYKRWLCTVTIPRCEDVMGGSRFSVVRNAFQAFPNGTTLPDNFRKGLNSSANNSSRNAWIDETVKPGPYKELLPCQDICYDVVQSCPSAIGFTCPQPGFPSFDVSYGERNSDTSSITCNYPGEARTKISAARVIRPGTFMLGVVSLMMWLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>I1RTC7</accession>
    <name>I1RTC7_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG07429.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T24797</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EMC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327199.1">
        <property type="nucleotide sequence ID" value="XM_011328897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RTC7"/>
    <dbReference type="FunCoup" id="I1RTC7">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RTC7"/>
    <dbReference type="EnsemblFungi" id="CEF83419">
        <property type="protein sequence ID" value="CEF83419"/>
        <property type="gene ID" value="FGRRES_07429"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07429"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24797"/>
    <dbReference type="eggNOG" id="KOG3060">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052388_0_0_1"/>
    <dbReference type="InParanoid" id="I1RTC7"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001208">
        <property type="entry name" value="Tetratricopeptide repeat domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="5">
        <location>
            <begin position="107"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF83419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="325" mass="36129" checksum="7C70849D8F3F1585" modified="2012-06-13" version="1">MATLLARPQAQLSPAEALHLAQQAPTILKGNPKAFSASPLVSLFSAAETVELWTIYENLIVTCLQTGDDDSAHLCLERLILRFGGENERVMALKGLIKEAEATNNNELSAVLKEYEDILQQDGTNIYIAKRRVALLRSMGKTPEAISSLVSLLEFNPTDAESWAELSDLYLSQGLYSQAIYALEEVIVLAPNAWNLHAKLGEVTLMAANETSDGSPQKYLANSVKRFCRSIELCEDYLRGYYGLKKVTDKILAEATKFKKQQPEEDEFSLPDQDTLKKLNQAATQKLAEIVRRYGAQEPLWQGYNVDEIAAARELLDKSSSEVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1RTD8</accession>
    <name>I1RTD8_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG07441.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T24827</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BIG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327213.1">
        <property type="nucleotide sequence ID" value="XM_011328911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RTD8"/>
    <dbReference type="STRING" id="229533.I1RTD8"/>
    <dbReference type="EnsemblFungi" id="CEF84361">
        <property type="protein sequence ID" value="CEF84361"/>
        <property type="gene ID" value="FGRRES_07441"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07441"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24827"/>
    <dbReference type="eggNOG" id="ENOG502S6TD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062461_0_0_1"/>
    <dbReference type="InParanoid" id="I1RTD8"/>
    <dbReference type="OrthoDB" id="9985059at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037654">
        <property type="entry name" value="Big1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046756">
        <property type="entry name" value="VAS1/VOA1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285:SF1">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20520">
        <property type="entry name" value="Ac45-VOA1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124507" description="Protein BIG1" evidence="11">
        <location>
            <begin position="19"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="V-type proton ATPase subunit S1/VOA1 transmembrane" evidence="12">
        <location>
            <begin position="225"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF84361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="274" mass="30021" checksum="6F821879FAE6D320" modified="2012-06-13" version="1">MRLQILASALALSGSAAAFSDSWPLVMFSTSKFSDATSNNQIQTRSQALEQVKDLLTSCPTDNYVLIAQEGANAADIRRTNANSNLHQAIARKEIQGKFIVSEVVGESIDADAIQDYIQTACYEQAKKVEPHFTLIKAGDDKEATEKWISNEQWMKDSYTVMFVGTPSTKAKAASASKKVSGSEKTIYESEFIEPLHMDLKRDVSEGSKAGNTTRDTRGLFEKYQFFTPGIFMAIITAIVLFSILGVGLRALASLEVSYGSFEKDMGPAAQKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>I1RX38</accession>
    <accession>A0A098DEF0</accession>
    <name>I1RX38_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cyclosome subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG08887.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T11091</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319820.1">
        <property type="nucleotide sequence ID" value="XM_011321518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RX38"/>
    <dbReference type="STRING" id="229533.I1RX38"/>
    <dbReference type="EnsemblFungi" id="CEF77348">
        <property type="protein sequence ID" value="CEF77348"/>
        <property type="gene ID" value="FGRRES_08887"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08887"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11091"/>
    <dbReference type="eggNOG" id="KOG4322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010478_0_0_1"/>
    <dbReference type="InParanoid" id="I1RX38"/>
    <dbReference type="OrthoDB" id="2504561at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="9">
        <location>
            <begin position="283"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF77348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="786" mass="89045" checksum="CB3FAA95E93823D3" modified="2012-06-13" version="1">MARYLNPAKVGLLALVELYVEGAVPSDAILPVLSFVTSHLMDHTPSKASANQSERWSKAERTVGLVISIKDFEKLLGSYPFLMGMPGRRLWDQFLGKLWDINSLDALHNFFDNLSEMLAKTKEERKRLAELGLPIETEEGIKLSPNSPFGTFVRRARLEYQRLQFHDCTELWKQFVRYRQPTASYLKRKIPGFGRLSFDNVLLMGEQEDWDHQSVMALASVAYGDMLTGDQSGSLPVSTDDIESLLEFQIEQMQKFGNRVPLEIRHQFHDLLNDSYLVPSLTHYLKFLDAWRAGDYPTAFDYLHRYFDYTMQNRDRLFYQYALMNLAVLQADFGCHKEAVAAMLETVSTARENRDMTCLNFALNWLFHFGRAHPDLVQNLESNSMLGTGKESLAFLRVKAKETGMWTLWSSVLLSEAKLGLLNGDSVATAFESIVRSSHIIVERNMKNMFGSHFSLTSALWDRLGLSTLSSATCEVFLRCHARNAIFDDELKLTCRLALLLALRGHYVEALSKLEQLEENSLRSWKPSQYWHKYQGIIKLKRDLHHNNLEGAERLLSQIIQSKMDDLEPDMAFLVDTLHIDYLTRRGDLQAAFSKVDDMMSQLEDEKKDVVLRVKLLLLKASLLDKCGRPQRGFTTAMRAASISWGARLIPCLWQAIGCVSNILISLGEFDAASQLLLAIIPRSLECETAGLAAQLYCYLADAYMGIAGKCEPKSSKRTEYMTKALAAVQKSFDHYSSIEDINMQCQMMAKKAMIMKLTGDLTLAADYAAAYVSLKKTAESLSHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1RXA7</accession>
    <accession>A0A098DNM2</accession>
    <name>I1RXA7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG08967.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T28241</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 77 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328844.1">
        <property type="nucleotide sequence ID" value="XM_011330542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RXA7"/>
    <dbReference type="EnsemblFungi" id="CEF83460">
        <property type="protein sequence ID" value="CEF83460"/>
        <property type="gene ID" value="FGRRES_08967"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08967"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G28241"/>
    <dbReference type="eggNOG" id="ENOG502S9ID">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039661_0_0_1"/>
    <dbReference type="InParanoid" id="I1RXA7"/>
    <dbReference type="OrthoDB" id="3763672at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF3">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="6">
        <location>
            <begin position="163"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF83460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="359" mass="41874" checksum="50CE58A0786776FA" modified="2012-06-13" version="1">MGYLYLRRGSRQRVVLLAIGILVSFGLIMHTWPFYSSSTRFKSSFSTLPIERAGNTSELMHHLWEPFLHDINATHFVTREGYQYTIGERNHRWREPLKKKLLILDVDTRLDTGAGTLLNKSPLNPSELTGRSGGMMNHYLYAMIHGYDYQFIRAPNYYKRHGTWVKVPMIKQALGTYETVVFLDTDAVFVYPEIPFEWLMSLWNITDETLVAMSNDPDSPRNRDGKGLVMMNTGFIIARQSTRTLSLFHDWNQCPTETKYEGCKRWMKDWAHEQAAFSNHVRYDYSTDDVRAIPRKDGNGGDGVFIRHNWFHKDSPAKDLRQLLLDILVKRIQAGFHHDLDNFLDASHYTHRFNKLDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1RXH3</accession>
    <accession>A0A098DNA1</accession>
    <name>I1RXH3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG09042.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T28059</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328755.1">
        <property type="nucleotide sequence ID" value="XM_011330453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RXH3"/>
    <dbReference type="STRING" id="229533.I1RXH3"/>
    <dbReference type="EnsemblFungi" id="CEF83330">
        <property type="protein sequence ID" value="CEF83330"/>
        <property type="gene ID" value="FGRRES_09042"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09042"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G28059"/>
    <dbReference type="eggNOG" id="ENOG502QRMK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032013_0_1_1"/>
    <dbReference type="InParanoid" id="I1RXH3"/>
    <dbReference type="OrthoDB" id="9975579at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.580">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054833">
        <property type="entry name" value="FormamaseFmdA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045496">
        <property type="entry name" value="FormamaseFmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891:SF1">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141130">
        <property type="entry name" value="Acetamidase/Formamidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF83330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="412" mass="44649" checksum="AAD46EF5BEF43B5C" modified="2012-06-13" version="1">MSRKIRTAQSVSFDIPAAEQPHLHNRWHPEVPSIATVEPGETVKIECLDWTGGQIGNNDSADDVRDVDLTKIHYLTGPFEIKGSEPGDLLVVNITDIQPFDHSPWGFTGVFSKDNGGGFLSEHYPDAAKAIWDFDGVYCSSRHIPGVRFPGLIHPGILGCAPSAEILAEWNRREGELATSMAGSHPDKVFAQPPNEINAHGGLAKGDVMARIAKEGARTIPGRPEHGGNCDINNISRGSKTYLPVHVPGAKFSVGDLHFSQGDGEISFCGAIEMAGIITIKFDLIKGGVKSRGLKSPVYRPGDMGPTFSPSRYLTFEGFSVDEQGKQHFMDATIAYRQSCLRAIEYLKQFGYSGEQIYLLLSCAPIRGAIAGIVDIPNACTTLGIPMDIFDFDISIESEPVVRNLGACPISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>I1RY98</accession>
    <name>I1RY98_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MADS-box MEF2 type transcription factor MIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG09339.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T27327</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Transcription factor acting downstream of the MPS1 MAP kinase (MAPK) cascade during conidiation and plant infection. Required for overcoming plant defense responses and the differentiation of secondary infectious hyphae in live plant cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with MAPK MPS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MEF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328411.1">
        <property type="nucleotide sequence ID" value="XM_011330109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RY98"/>
    <dbReference type="SMR" id="I1RY98"/>
    <dbReference type="STRING" id="229533.I1RY98"/>
    <dbReference type="EnsemblFungi" id="CEF83218">
        <property type="protein sequence ID" value="CEF83218"/>
        <property type="gene ID" value="FGRRES_09339"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09339"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27327"/>
    <dbReference type="eggNOG" id="KOG0014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024080_1_0_1"/>
    <dbReference type="InParanoid" id="I1RY98"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="PHI-base" id="PHI:1536"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000013">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021934">
        <property type="entry name" value="Sox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51516">
        <property type="entry name" value="SOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Sox C-terminal" evidence="12">
        <location>
            <begin position="271"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="71"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="603"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="490"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="616"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="635"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF83218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="681" mass="73384" checksum="7E883A8F837EA5E3" modified="2012-06-13" version="1">MGRRKIEIKAIKDDRNRSVTFLKRKGGLFKKAHELSVLCSVDVAVFIFGNNKKLYEYSSADMRELIHRYQYHGGPSEHKGPADFNGGNDDDDEEEGDGTPPHGSEVVENQMMPPHPYGQHQPPFPQIRHQTPSASPPIGNGGGPFQAHPGHPVQRTHTPQPSIGSRPTSRNDMRRMGPGMVQPPPPPGPQHPAMNYMATPPIYNSPHPPSGLLPQHAPHPQYGYHQQPPPMPQHQQHPQHQPQHQQHQPQHQQHQPHQPGPYMEDRRSPMPSPMPPAYSSQPPSQGIQAPARPTPSPQPNQQQHPTSTYSQMSPPPPQPERRLQDLPPPPPPPVEIKTEPQERPQPPLLNTDSAIKKLPQRKSHSIFTPIEENRSILSQHLASFTESGKSESAAAAAAANAANAANRSQSVDVAALNRAADASKSSPHMPQRASTQTDSKRTGSLSSIPESAPTPPSRSNSAKLPGGPGGARPRGPRLTVQIPDGGSEGSGSARTAESNSPRNPAETTTQVPQRHNSQSSLVLPPPSPSASAILSAGATGPPNPFARPPPQQNVNGETPVSALPSRFLTNELLPSPSSFYPDWNFRGGDSNTLPSPLNFATPVVGSGPSFLRDDTLNTTPNANSSILKELKDPTPNANGTSSQNLSVSNHSTATKRKTPELGATTQSDASEESDAKRLRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RYS3</accession>
    <name>I1RYS3_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">3'(2'),5'-bisphosphate nucleotidase</fullName>
            <ecNumber evidence="3 11">3.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG09532.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T26863</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="3 11"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328185.1">
        <property type="nucleotide sequence ID" value="XM_011329883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RYS3"/>
    <dbReference type="FunCoup" id="I1RYS3">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RYS3"/>
    <dbReference type="EnsemblFungi" id="CEF85133">
        <property type="protein sequence ID" value="CEF85133"/>
        <property type="gene ID" value="FGRRES_09532"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09532"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26863"/>
    <dbReference type="eggNOG" id="KOG1528">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033446_1_1_1"/>
    <dbReference type="InParanoid" id="I1RYS3"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="PHI-base" id="PHI:5760"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052829">
        <property type="term" value="F:inositol-1,3,4-trisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004441">
        <property type="term" value="F:inositol-1,4-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042538">
        <property type="term" value="P:hyperosmotic salinity response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043647">
        <property type="term" value="P:inositol phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016078">
        <property type="term" value="P:tRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000015">
        <property type="entry name" value="3',5'-bisphosphate nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000003">
        <property type="entry name" value="PAP-specific phosphatase HAL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006239">
        <property type="entry name" value="DPNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01330">
        <property type="entry name" value="bisphos_HAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF6">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF85133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="357" mass="37810" checksum="506673ACD38D9C82" modified="2012-06-13" version="1">MAAPSYASELKIAELAVQRATILTKRVFHEKAKGTVDKNDKSPVTIGDFGAQALIIAALRHNFPDDAIVAEEEAAQLQEDANLKQTIWELVSSTKLDDEDAEKQLGGPIKDVEDMLELIDRGGSQGGSSGRIWAIDPIDGTKGFLRGGQYAVCLGLMIDGDVKVGVLGCPNLPVDDSARLTSDIGANATDEGRGVIFSAVQGHGANSRPLTTSALSAQKAISMRSLDDLSKATFCESVEAGHSAHDDQALISKKLGITQDSVRMDSQAKYGSIARGAGDIYLRLPVKATYQEKIWDHAAGDLIVREAGGEVTDIHGKRLDFSVGRTLANNKGVIAAPAAVHAKVLEAVQEVLSAKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZR6</accession>
    <name>I1RZR6_GIBZE</name>
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        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="8" type="primary">FG09919.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T06835</name>
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    <organism evidence="8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318825.1">
        <property type="nucleotide sequence ID" value="XM_011320523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZR6"/>
    <dbReference type="FunCoup" id="I1RZR6">
        <property type="interactions" value="348"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RZR6"/>
    <dbReference type="EnsemblFungi" id="CEF75222">
        <property type="protein sequence ID" value="CEF75222"/>
        <property type="gene ID" value="FGRRES_09919"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09919"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06835"/>
    <dbReference type="eggNOG" id="KOG2402">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019525_0_0_1"/>
    <dbReference type="InParanoid" id="I1RZR6"/>
    <dbReference type="OrthoDB" id="166375at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.200:FF:000005">
        <property type="entry name" value="Related to Pol II transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="6">
        <location>
            <begin position="247"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="449"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <begin position="453"/>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="532"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF75222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="596" mass="66872" checksum="BE6A1EEADA4B7BFD" modified="2012-06-13" version="1">MSDVEDDLLDLAGRSSDDEGSDNGSRRGSAPPPVKRSGSKRETGSKARRGGGDDSEEEGEASSAPGTPNSLESAPMDESDSDAEPSRGRAAAADDDDENYPVDGRYKSQKEKAEIMAMPELEREQIIADRMTEIERQRQNRLLRQMVSNMENEERKQVKKKRSAGTAELEDGDRKASRPRTETKRETAMDSLRQAKAEKARRREDLEKRKDNYSSRRGDSGAEDSDDDYNRGRSPTPDVDEARDQPPAELRDYDRVRLGRNEFAQVCFHPGFEQGIIGCYIRIALGPHPETGIEQYRMAVIKGFSTSRPYAIQGPQGVLVTDQYVKAAHGKAIKEFPFIAASSGKFTDSELNRYKVTCHNEGVTLPTKAYLTDKVDDINRLINHSWTSEEIKTRLARISDLKRRFDPAERERIAKLLDEARQRGDDDRAEELQEELDNLGSQRLAFRTSLGSKHSEEPKAQSEQDRLAERNRENRRLNAEAVRKAQLKEKAKSKEIEAALKRGETYQGDMSRRLRTKAKFVHDANEKVEQKSAANGNGAGTPGNSTSKSAAKSQLLPHMMKLQEEKLKEKGIPTIHKPLMDDDVIGSLDLDIDVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1S062</accession>
    <name>I1S062_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">MICOS complex subunit MIC12</fullName>
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        <alternativeName>
            <fullName evidence="10 11">Altered inheritance of mitochondria protein 5, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Found in mitochondrial proteome protein 51</fullName>
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    </protein>
    <gene>
        <name evidence="14" type="primary">FG10078.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T07229</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MICOS complex subunit Mic12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319010.1">
        <property type="nucleotide sequence ID" value="XM_011320708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S062"/>
    <dbReference type="EnsemblFungi" id="CEF75419">
        <property type="protein sequence ID" value="CEF75419"/>
        <property type="gene ID" value="FGRRES_10078"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10078"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07229"/>
    <dbReference type="eggNOG" id="ENOG502SC1K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056216_0_0_1"/>
    <dbReference type="InParanoid" id="I1S062"/>
    <dbReference type="OrthoDB" id="4037694at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031463">
        <property type="entry name" value="Mic12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17050">
        <property type="entry name" value="AIM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="204"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="208"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF75419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="240" mass="26239" checksum="1CD1F20B5EC371BD" modified="2012-06-13" version="1">MGFTTGFTGGVTLTLSLAYLSVLAHQRTREQQGSALRAQALALQGLIDPLPPLPPPTRSEVAAAQRAKTVEIAKDRWNTEVENAARWVQHTDWVQVREGLEDTASRLWSRAVGASPSEVADQAGQKAKEAERRAKPVVKEEAAKLGDASGKVAAAAKSAYKKAKAETKEFASVILDHSKDKENVDIAQEDGTLSVLTPVERALQQRFNKPEDKVNKTVEDALKERYKPMDSRDNTQLRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1S0J2</accession>
    <name>I1S0J2_GIBZE</name>
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        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG10220.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T07571</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319167.1">
        <property type="nucleotide sequence ID" value="XM_011320865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S0J2"/>
    <dbReference type="EnsemblFungi" id="CEF75589">
        <property type="protein sequence ID" value="CEF75589"/>
        <property type="gene ID" value="FGRRES_10220"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10220"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07571"/>
    <dbReference type="eggNOG" id="KOG4300">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_037990_6_0_1"/>
    <dbReference type="InParanoid" id="I1S0J2"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
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    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF75589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="303" mass="33963" checksum="3233EBCFA52ABADB" modified="2012-06-13" version="1">MAVLSTLKELAEQLIDPYLFMSIAVRFLPSTILEVIRNKDFRTLLSPSRFKEAWFGNFWAFIGPQVKANAESKVIPLLEGRVKNGRMGDEVVERPINGVVLEIGAGTGMWADVFAKVNVGVNTEGSEDGELRRRKGEESGLTRVYGIEPNPKSAATLRRRVKEIGLDGVYEVVPVGIESITDPKAWDGRIEPESVDCIVTILCLCSIPEPEKNIKLLYQSLKKGGRWYAYEHVRIDQSRSFFLRAYQWVTGLVWSQVMGSCRICRSTGKTLREAGPWEKIDLAPPVGEARFRLLPHVLGTLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I1S0L8</accession>
    <name>I1S0L8_GIBZE</name>
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        <submittedName>
            <fullName evidence="5">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG10251.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T07651</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319203.1">
        <property type="nucleotide sequence ID" value="XM_011320901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S0L8"/>
    <dbReference type="SMR" id="I1S0L8"/>
    <dbReference type="FunCoup" id="I1S0L8">
        <property type="interactions" value="584"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1S0L8"/>
    <dbReference type="EnsemblFungi" id="CEF75629">
        <property type="protein sequence ID" value="CEF75629"/>
        <property type="gene ID" value="FGRRES_10251"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10251"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07651"/>
    <dbReference type="eggNOG" id="KOG0315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_5_1"/>
    <dbReference type="InParanoid" id="I1S0L8"/>
    <dbReference type="OrthoDB" id="400at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000339">
        <property type="entry name" value="WD-repeat protein pop3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="71"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="203"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="256"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF75629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="317" mass="35414" checksum="EE2D084CC90B6080" modified="2012-06-13" version="1">MSVILCTAGYDHTIRFWEALSGICSRTIQHPDSQVNRLCISPDKRYLAAAGHHTVKLYDIKSTNPNPLLTFEGHTGNITGVAFHCEGKWMVTSSEDGTVKIWETRTGTIQRSYNHGCPANDVVIHPNQGEIISCDRSGSVRVWDLAENNCSHELIPEEDVSVSSVTVASDGSLLCAANNAGNVFVWNLIQSFDRTQLVPVTHFNAHKEYITRILLSPDVKKLATCSADHTAKIWEVKNIEPTPDQEPKPYPLEATLTGHQRWVWDCAFSADSAYLVTACSDHYARLWELHSQQIIRQYNGHHRGAVCVALNDYSETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>I1S2C4</accession>
    <accession>A0A098DY41</accession>
    <name>I1S2C4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG10913.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T20789</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325466.1">
        <property type="nucleotide sequence ID" value="XM_011327164.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I1S2C4">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1S2C4"/>
    <dbReference type="EnsemblFungi" id="CEF86247">
        <property type="protein sequence ID" value="CEF86247"/>
        <property type="gene ID" value="FGRRES_10913"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10913"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20789"/>
    <dbReference type="eggNOG" id="KOG0238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002162_4_0_1"/>
    <dbReference type="InParanoid" id="I1S2C4"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="PHI-base" id="PHI:5068"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:urea carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Amidase signature (AS) domain"/>
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        <property type="entry name" value="ATP-grasp fold, B domain"/>
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        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Allophanate_hydrolase"/>
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        <property type="entry name" value="AS_sf"/>
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    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
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    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
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    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
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    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
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    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014084">
        <property type="entry name" value="Urea_COase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02713">
        <property type="entry name" value="allophanate_hyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006043">
        <property type="entry name" value="PRK08186.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00724">
        <property type="entry name" value="urea_amlyse_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02712">
        <property type="entry name" value="urea_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF128">
        <property type="entry name" value="UREA AMIDOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21986">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
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    <dbReference type="SUPFAM" id="SSF160467">
        <property type="entry name" value="PH0987 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="10">
        <location>
            <begin position="642"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="761"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="1764"/>
            <end position="1833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF86247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1834" mass="199010" checksum="DD880E7C456878F9" modified="2012-06-13" version="1">MAELELVTNAHDNVIGGRDASNPLTIAQWKAAQVTAGGLERLLSIVKSEGEANSTTHSWITLATPEQVKLQWTNLEALGPQATTLPLYGVPFAVKDNIDAQGFITTAACPTFRSVPAASDATVVSKLKAAGAILIGKTNLDQFATGLVGTRSPYGAVPNSFDPTRVSGGSSSGSAVVVARGIVPFSLGTDTAGSGRVPAGLNNIVGLKPTRGAISTHGVLPACRTLDCISIFSFTVTDAETVLSIAEGYDISDAYSRSRHDTSSTSFDAFGGSVELLKPNLAICASPKWFGHGNQRSAYEKALIKAEILGWSLVPMDFDPLFQLARLLYDGPWVAERYEAIRDFIERCPSDDVDPVVRKIIVRAQSLSAADVFRGEYLRKELTRKVEHAFAKFDGILVPTSPTFPTLDEVHKSPVEENSILGTYTNFVNFLDWSALAIPAGFRADELPFGVTLISNRWNEPCLFSWAKVWLGDEKRFLGATDVRAEESQSMVPSTPSDHIPFAIIASHPSSSPSTKGLVSFGGKFWKKNTTSSSYRLYALDTPQGTKELGLKRMSAKDGAEIDIEVWHLPKPSVADFILKFSHPLAFGSIELSDESWVRGFVCEPCDFDNAIDITEHGSWTACHELLEAKIKPPSDNNQKRFISTILVANRGEIAVRIIETVHKMGLRAVAIYSDSDANATHVSRADLALKLRGASVSDTYLNMDQILELAVHSSVDAIIPGYGFLSENADFAAAVEDRGMTWVGPTPQQMAELGLKHRARSIAVKVGVPVIPGCEMLLESLKEAILESNKIGFPLMLKSTAGGGGIGLSYCKDVEGLSATFEVVQRQAVANFGDGGVFLERYIERARHVEIQILGDGTGRVVSAGERDCSLQRRHQKIVEESPAGMIPKSVRTEMKEAALRLASSVRYRNVGTVEFIYDLDTKEYYFLEVNTRLQVEHPVTELVTGLDLVECMLNIANGNATQLFEANFPTTGASIEVRVYAENPLRSFRPCFGCVTALEFPSSLRVDTWVKVDTEITTSFDPLIAKLVSFGADREEAIENMVSGLAATRIEGVQTNLDYLHQIVSSPMFRSGQYTTKSLDAFQFKSSSFEVLEPGALTTVQDYPGRTGYWDIGVPPSGPMDSLSSRLANRIVGNPPNAAGLEFTLSGPALKFHCNTVVVISGGVAPVTVDGVPVSQNRTLSINAHQTLCIGAIEKGHRVYLAIRGGVEVPVVMGSRSTFELGKLGGFGGRKLQQHDVLQIGDPGICVSESFHSTISIPVPTYSKASWIVRVIPGPHGAPSYFSSESAKSLYLCEWKVHHNSNRLGVRLTGPQPEWSRKTGGKAGLHPSNIHDAPYSIGSVSFTGDEAIVLGCDGPSLGGFVVFCVVCSADLWKIGQARPGDTIRFVPIEVESAMELEEQLDQAIESLSPLPIIEEVFSDKAALEQILEVIPTIVGVIEHDGEVITAHQAGDRALLLEFGDGLVFDLRHNFSISAFCENHQKKPIAGVVELTPGIFSLHVTYDQGLSPKLILTRVREHICSYTVSSKISSRQIRLPIAFDDSVNRAAVARYTATIRSDAPWLPSNINFLEKLNGIQDLTKVLTDAEFIVVGLGDVFMGSPCAIPLDQRHRLFGTKYNPSRSFTPRGAVGVGGQYMCIYAADSPGGYQLVGRTVEIWDSSLLDVKGSNAWFFRRFDRISFYPVSEHVLDHTPRSELVQITDGVFDLAEYETWLEENKESISASASQQEQAIASAAFLEDLLLPYQVDSFPNDQDPSPRCSDISGARVTATMPGRCYKVMVKEGQTVEKGDIVLCIESSKMEVEVCSPVSGKCLAVMVQAGVLVHAGEDLIIIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1S2J2</accession>
    <accession>A0A098E3S4</accession>
    <name>I1S2J2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG10987.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T20951</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325384.1">
        <property type="nucleotide sequence ID" value="XM_011327082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S2J2"/>
    <dbReference type="EnsemblFungi" id="CEF88751">
        <property type="protein sequence ID" value="CEF88751"/>
        <property type="gene ID" value="FGRRES_10987"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10987"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20951"/>
    <dbReference type="eggNOG" id="ENOG502S8UP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_809039_0_0_1"/>
    <dbReference type="InParanoid" id="I1S2J2"/>
    <dbReference type="OrthoDB" id="3140657at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057:SF2">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF88751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="408" mass="47554" checksum="3768BB011161770C" modified="2012-06-13" version="1">MQHRHDMLDTILYWIAGTGNKDTRQIIDPDAVFHGDKIQEYSEGKSSITDLADFSQPAIPLQQLTITNLPDNHDDRLHTSESFLKLMSMASLRDLRIHVEAQRDLHHPVRAPDGSSPFSPGKYKFFNNLYVSWLAPDIAKNLQTLTLHCKDFWGWFPKMDLRRIELPQLKVLSLGRYVFSHQWQIDWFASIGKQNGSGGLEELYLHDCPILYEATHIGPFDTFDPGYPLLKSVLGIVGERETHKYPIRWHAIFSQWARSLNKLKVFHMGRSTYQNSLQDTFTKTHQDVQDKPLRQRIWYDLLEELASPCPSGPVAHSRLEHASNLEGQMTSVKFNQNRDFQMKYIKYNIERERYNAYWPWVHPGEPYECWAPEEDTVMRDDAAYEMLMDAVDSRAINHDDMSNVFNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1S3F7</accession>
    <accession>A0A098DZH7</accession>
    <name>I1S3F7_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribokinase</fullName>
            <shortName evidence="9">RK</shortName>
            <ecNumber evidence="9">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG11337.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T21817</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="9"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325903.1">
        <property type="nucleotide sequence ID" value="XM_011327601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S3F7"/>
    <dbReference type="FunCoup" id="I1S3F7">
        <property type="interactions" value="1087"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1S3F7"/>
    <dbReference type="EnsemblFungi" id="CEF86268">
        <property type="protein sequence ID" value="CEF86268"/>
        <property type="gene ID" value="FGRRES_11337"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11337"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21817"/>
    <dbReference type="eggNOG" id="KOG2855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_2_0_1"/>
    <dbReference type="InParanoid" id="I1S3F7"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="10">
        <location>
            <begin position="6"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="41"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="237"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
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    <feature type="binding site" evidence="9">
        <location>
            <begin position="269"/>
            <end position="270"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
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            <position position="306"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
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            <position position="309"/>
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            <position position="315"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF86268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="323" mass="33725" checksum="C72E39252C69BEA2" modified="2012-06-13" version="1">MPKPVISVLGSLNIDLVSYVPHHPLPGETITSSQFNVFPGGKGANQAVACAKLSRTSDFKDASVDVVMIGAIGADAYGTTLLDSLKSYDVGTDSIIVNRDGGAGSQSGIAMIIVDEPTGQNRIILSPGANNSLQPSQFQTIPGPAPALLIMQLEIPLETVIQAFQAAKATGTPVLLNPAPAQALPTEIYKGLAHLILNETEAALLSDKDELEFENISVVEQAASDFLARGVHNVVITLGGKGAYFANDTGAKGLIPAQKVKVVDTTAAGDTFIGSYAVEVALAGQRAKTFDIEKAVRSGIRASSHTVARRGAQVSIPWKDELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1S3X5</accession>
    <name>I1S3X5_GIBZE</name>
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        <submittedName>
            <fullName evidence="9">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG11525.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T16027</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323102.1">
        <property type="nucleotide sequence ID" value="XM_011324800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S3X5"/>
    <dbReference type="EnsemblFungi" id="CEF79813">
        <property type="protein sequence ID" value="CEF79813"/>
        <property type="gene ID" value="FGRRES_11525"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11525"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16027"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_1_3_1"/>
    <dbReference type="InParanoid" id="I1S3X5"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
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    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TCRTETB"/>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="186"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="492"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="128"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF79813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="568" mass="63217" checksum="C207092DDBE7202C" modified="2012-06-13" version="1">MSRSNSPKLSRAGSHSSLWRSWSPMLDGLTNYDKSRRNYPWLANDDMEEGLYEPQTSRHSRRLSLLAEVPDTVSQSDRSIKSTDDLEEQSAPGPLLEPQDGDPNLVTWDGLQDPSNPHNWSKHKKWVSTILVSCFTFISPVSSTMLAPALPDLAAELKTSSDFETYLLMSIFLLAYAIGPFVLAPLSEMFGRVVVLQSANMFYLVFNTVCGFSQTKQQMLVFRFLSGLGGSAPQALGGGVLSDCWRKEERGTATAIYSLAPFLGPAVGPIAAGYLTQHLNWRWIFWVVSIADAVVQVLAFLFLQETYPPKILKIKARNLRKLTGNKYLHTVFEQLDRTFISLLLDNLKRPFIMLFTQPAIQITALYRAYLYGLMYLVFASFPVVWEQQYNQQPGRASLNYISLGIGFVIGLQISGPSIDKVYIMLKDRHNHPGRPEFRVPLMFPTALVTPAGLVLYGVAAHLKLHWIIPNIGAAIFAAGLILSFQCAQTYIIDSYERYSASATGAAAFVRTMAGFSFPLFAPAMYQKLGIAWGNGLLAGTAMVLGLLAPVVLWRYGEYIRRKSPYCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I1S4K5</accession>
    <accession>A0A098D1V5</accession>
    <name>I1S4K5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T01271</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316171.1">
        <property type="nucleotide sequence ID" value="XM_011317869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S4K5"/>
    <dbReference type="EnsemblFungi" id="CEF72437">
        <property type="protein sequence ID" value="CEF72437"/>
        <property type="gene ID" value="FGRRES_11773"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11773"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01271"/>
    <dbReference type="HOGENOM" id="CLU_2197218_0_0_1"/>
    <dbReference type="InParanoid" id="I1S4K5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF72437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="108" mass="12942" checksum="431AF8BD022011A5" modified="2012-06-13" version="1">MFSRFHKSFKPSHTIPSHTISRFTGYYASHTPCLSRNLNTSRNFRRLRNTQTNINEMHKWIREIRANQKEITANQKREEIWRKELLDAISRLEPKQSFFGKLFSSSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1S503</accession>
    <name>I1S503_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Molybdopterin synthase sulfur carrier subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Common component for nitrate reductase and xanthine dehydrogenase protein G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor synthesis protein 2 small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor synthesis protein 2A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sulfur carrier protein MOCS2A</fullName>
            <shortName evidence="5">MOCS2A</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG01262.1</name>
        <name evidence="5" type="synonym">cnxG</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T03127</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by UBA4. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoaD family. MOCS2A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317041.1">
        <property type="nucleotide sequence ID" value="XM_011318739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S503"/>
    <dbReference type="STRING" id="229533.I1S503"/>
    <dbReference type="EnsemblFungi" id="CEF73365">
        <property type="protein sequence ID" value="CEF73365"/>
        <property type="gene ID" value="FGRRES_11921"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11921"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03127"/>
    <dbReference type="eggNOG" id="ENOG502SD3I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114601_6_1_1"/>
    <dbReference type="InParanoid" id="I1S503"/>
    <dbReference type="OrthoDB" id="5595860at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990133">
        <property type="term" value="C:molybdopterin adenylyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990140">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00754">
        <property type="entry name" value="Ubl_MoaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03051">
        <property type="entry name" value="MOCS2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044672">
        <property type="entry name" value="MOCS2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028887">
        <property type="entry name" value="MOCS2A_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE SULFUR CARRIER SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359:SF1">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE SULFUR CARRIER SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="1-thioglycine; alternate" evidence="5">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycyl adenylate; alternate" evidence="5">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF73365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="95" mass="10094" checksum="5A45D77579060AD4" modified="2012-06-13" version="1">MSAPKPPAGHFNVLFFASASSFTGKDHEALPATMALSKLFAELENRYPGIKAKILDSCLVTVNLDYVDLPGEEGAEDTMIQEADEVAIIPPVSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I1S5Y9</accession>
    <name>I1S5Y9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T15229</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321192.1">
        <property type="nucleotide sequence ID" value="XM_011322890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S5Y9"/>
    <dbReference type="EnsemblFungi" id="CEF79415">
        <property type="protein sequence ID" value="CEF79415"/>
        <property type="gene ID" value="FGRRES_12260"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12260"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15229"/>
    <dbReference type="HOGENOM" id="CLU_1669529_0_0_1"/>
    <dbReference type="InParanoid" id="I1S5Y9"/>
    <dbReference type="OrthoDB" id="10328492at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF79415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="158" mass="18124" checksum="E41A6BE1E655C0EE" modified="2012-06-13" version="1">MVTSHGGSSLLFNERKNTACNRQKKRRDNAKLVTEEEGEEGAGGKERVSRKQVDKKQQVQIHQQDTSDKKKCRIAMLQNGVNGLRSRPEARWYRRREDTTSKGLTVMAFPDYDIHASISGATITVPWYYQEAIFNYLWYTDTGINLLVEFSTISNFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I1S6C2</accession>
    <accession>A0A098DJB6</accession>
    <name>I1S6C2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T13523</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78565.1"/>
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        <property type="nucleotide sequence ID" value="XM_011323680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S6C2"/>
    <dbReference type="EnsemblFungi" id="CEF78565">
        <property type="protein sequence ID" value="CEF78565"/>
        <property type="gene ID" value="FGRRES_12393"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12393"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13523"/>
    <dbReference type="HOGENOM" id="CLU_2061699_0_0_1"/>
    <dbReference type="InParanoid" id="I1S6C2"/>
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        <property type="component" value="Chromosome 2"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF78565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="119" mass="13070" checksum="FA099C373F68058C" modified="2012-06-13" version="1">MSHKQLPGQGMSQERVAFGCRVIAIRAQTTIPSWQSLDTESVSEVDESFVKPIDLSCGQSWGSVGDSSTKDKVSHWMMVPMHVMQCCSGVTPTFVPHDVLISPDQDSTDHYGVMLELIS</sequence>
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    <accession>A0A098DJ42</accession>
    <name>I1S6D0_GIBZE</name>
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            <fullName evidence="2">Chromosome 2, complete genome</fullName>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322048.1">
        <property type="nucleotide sequence ID" value="XM_011323746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S6D0"/>
    <dbReference type="EnsemblFungi" id="CEF78495">
        <property type="protein sequence ID" value="CEF78495"/>
        <property type="gene ID" value="FGRRES_12401"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12401"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13383"/>
    <dbReference type="HOGENOM" id="CLU_187043_0_0_1"/>
    <dbReference type="InParanoid" id="I1S6D0"/>
    <dbReference type="OrthoDB" id="5052993at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF78495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="99" mass="11301" checksum="2515411F2011ED1C" modified="2012-06-13" version="1">MTNFRPHPLPFTSKDPRMQDPKGEHVDGGDTNLNHFSEAMFSCPVVVATEPAYALARQIKKMRQKRADKKAEEEKRSTGNAEKEKWHGDDKKEHGNLEP</sequence>
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        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_011326138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S7K3"/>
    <dbReference type="EnsemblFungi" id="CEF86672">
        <property type="protein sequence ID" value="CEF86672"/>
        <property type="gene ID" value="FGRRES_12826"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12826"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18891"/>
    <dbReference type="HOGENOM" id="CLU_125559_0_0_1"/>
    <dbReference type="InParanoid" id="I1S7K3"/>
    <dbReference type="OrthoDB" id="5094013at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF86672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="142" mass="16451" checksum="ABD48C4E82986C68" modified="2012-06-13" version="1">MFKRGVGAVSYVMRDSIQKEIDDLEEYLFSDNKAEVKGWWREIKSAQKWLYVMYPVGFDTSKIDPKYWGSPDDPNMTCSRMRLLEIQRNLFKLIFKANTQDDELQAKVFTAVQKAVQEIKEFEAGAADSNNQADNNSQYSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1S7T4</accession>
    <name>I1S7T4_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
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        <name evidence="2" type="ORF">FGRAMPH1_01T20111</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325014.1">
        <property type="nucleotide sequence ID" value="XM_011326712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S7T4"/>
    <dbReference type="STRING" id="229533.I1S7T4"/>
    <dbReference type="EnsemblFungi" id="CEF86538">
        <property type="protein sequence ID" value="CEF86538"/>
        <property type="gene ID" value="FGRRES_12909"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12909"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20111"/>
    <dbReference type="eggNOG" id="KOG3276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130694_1_0_1"/>
    <dbReference type="InParanoid" id="I1S7T4"/>
    <dbReference type="OrthoDB" id="244097at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00251">
        <property type="entry name" value="DUF167 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420:SF7">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF86538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="117" mass="12267" checksum="74828E7B6B6E5A50" modified="2012-06-13" version="1">MASSSAIRFVTGSKKSPLGSLHLQLHVKPGASKNREGVIAVTEDAIELCVSAQAREGEANKAVVQVLSGILGVPKSSLQLTHGMKSRDKTVVLGGIKGDGEDYAKTIREILDKAAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I1S7Y4</accession>
    <accession>A0A098DQQ2</accession>
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        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T22853</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_011327986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S7Y4"/>
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        <property type="protein sequence ID" value="CEF84175"/>
        <property type="gene ID" value="FGRRES_12959"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22853"/>
    <dbReference type="HOGENOM" id="CLU_2073388_0_0_1"/>
    <dbReference type="InParanoid" id="I1S7Y4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF84175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="118" mass="13421" checksum="E3FB52B200A2C5C4" modified="2012-06-13" version="1">MVFATINVLLDVPPDPTSKPCRPHERLKRKLLFQFSLKAFVSRQLDYPVLGIVWYWPVETAEHLVDGCVSKICVTLSGLRVERNGGKVYTKNRRSPTQIIPLFVSRQGSVLKGDREIV</sequence>
</entry>
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    <accession>I1S887</accession>
    <accession>A0A098DTT0</accession>
    <name>I1S887_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
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        <name evidence="3" type="primary">FG07124.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T24021</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326831.1">
        <property type="nucleotide sequence ID" value="XM_011328529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S887"/>
    <dbReference type="STRING" id="229533.I1S887"/>
    <dbReference type="EnsemblFungi" id="CEF84767">
        <property type="protein sequence ID" value="CEF84767"/>
        <property type="gene ID" value="FGRRES_13065"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13065"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24021"/>
    <dbReference type="eggNOG" id="ENOG502SPSM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_554366_0_0_1"/>
    <dbReference type="InParanoid" id="I1S887"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF84767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="473" mass="53821" checksum="9B32AAC0E1E7E39B" modified="2012-06-13" version="1">MTFLSSPERRERPSRAAAPTKNMKELDSEDDDLRFKPRISSSEGFLRADNNNSSVGFSPDSITVISAQSIASSMPSSMETLNRSTSPKKRNSPEAESESPTKKSRMIRIKTNKSIQAMTPALSQASVTPQPAFSSIPEIEAMHKCISSLESRIKKNAADRNEDQKNLASIKQALQEAQAANTCEKDLTHPTDDQGLRKENEELKRRISEKNHFIATLRQDRIAPSSFKLMDCDVETEWKGIAFDIRNFVSQVLTKQPYRDSAPRGANMRDVEALKKHQKKNIHTAPFHFQRYIWKHLVDDIFQAGKATWGGPAGNSFHRYCLEISEIDFEDMTQLSTFKSSQAHVMSKCFDEHNREEAKSIAEEMALTLKIFMDPEEMKPKTNPQKRLMSIVRKAVELNDKFLRSRAFYLTNWLQCDWGWDDVEIRYSTGETGGVKTVDVEISPRLRKIGNADGRHFDQAREICQPMVTVHLS</sequence>
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    <accession>I1S9F8</accession>
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            <fullName evidence="5">Chromosome 4, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
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                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_011328825.1">
        <property type="nucleotide sequence ID" value="XM_011330523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S9F8"/>
    <dbReference type="FunCoup" id="I1S9F8">
        <property type="interactions" value="287"/>
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    <dbReference type="STRING" id="229533.I1S9F8"/>
    <dbReference type="EnsemblFungi" id="CEF84893">
        <property type="protein sequence ID" value="CEF84893"/>
        <property type="gene ID" value="FGRRES_13489"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13489"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G28199"/>
    <dbReference type="eggNOG" id="KOG1338">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017135_0_0_1"/>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF84893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="465" mass="53075" checksum="DD11D92DBAFD8B1E" modified="2012-06-13" version="1">MNSTFFDGASEKFLQWFKTLSGSTFSDDIKIVDLRDRNAGRGIIALKDIPAETTLFTIPRKGIINTETSELPKKIPDVFDLDKPDEDDVPGLDSWSSLILIMIYEYLQGDSSQWKSYFDVLPSSFDTPMFWSENELDQLQASHMRHKIGKADAEDMFKKTLVPIIRSNPSIFNAENRSDYELVEIAHRMGSTIMAYAFDLENDEEEEEETEEWVEDREGKSMMGMVPMADILNADAEFNAHVNHEEESLTVTSLRPIKAGEEILNYYGPHPNSELLRRYGYVTEKHSRYDVVEIPWDIVESVLTNFGISSKILEQIRGEFEEEEEFEDTFVLERDTGEVNSDGTFAEPAKFEGMPEDLQEQLKSFLKGIKKLQSDTIPDKRKRDEIHQAVLVKTLEALAARYPTSISEDQILLNGQNLDQRARMATVVRLGEKKLLQEAIATFSEDVEMTMDDESGPAKRTKRSG</sequence>
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    <accession>I1SA60</accession>
    <accession>A0A098DB98</accession>
    <name>I1SA60_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
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    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T07847</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319296.1">
        <property type="nucleotide sequence ID" value="XM_011320994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1SA60"/>
    <dbReference type="EnsemblFungi" id="CEF75727">
        <property type="protein sequence ID" value="CEF75727"/>
        <property type="gene ID" value="FGRRES_13741"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13741"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07847"/>
    <dbReference type="eggNOG" id="ENOG502RWZ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2386202_0_0_1"/>
    <dbReference type="InParanoid" id="I1SA60"/>
    <dbReference type="OrthoDB" id="5080543at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF75727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="100" mass="11160" checksum="BEE6BCF97712A7F3" modified="2012-06-13" version="1">MSCITSRIKTFLSGSSSLSSSASQYDPSSEKNAQSYQLQTVSQSDATPPPPPYSSTPSCDQSLSKPFILEFEPPSQQGYRVSRPSESNRQRFIYRQITRE</sequence>
</entry>
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    <accession>I1SA93</accession>
    <name>I1SA93_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
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    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T08253</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319487.1">
        <property type="nucleotide sequence ID" value="XM_011321185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1SA93"/>
    <dbReference type="EnsemblFungi" id="CEF75930">
        <property type="protein sequence ID" value="CEF75930"/>
        <property type="gene ID" value="FGRRES_13774"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13774"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08253"/>
    <dbReference type="HOGENOM" id="CLU_2158627_0_0_1"/>
    <dbReference type="InParanoid" id="I1SA93"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124848" evidence="1">
        <location>
            <begin position="19"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF75930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="111" mass="12270" checksum="2F49DB091EAF7536" modified="2012-06-13" version="1">MTAGLGWAPFVWVGLVFASQWDWTQILAPRFDSKAVSLFLVSSLRLSPMIKNSRTLLLLSRLSSSCLSSEPEAQAELLSSQSRLHLQSWMVLYYATTNKMSSLLAEASNSG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q4HYQ4</accession>
    <accession>A0A0E0RVD1</accession>
    <accession>V6RPP5</accession>
    <name>SPT6_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName>Transcription elongation factor SPT6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Chromatin elongation factor SPT6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SPT6</name>
        <name type="ORF">FGRRES_09904</name>
        <name type="ORF">FGSG_09904</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SPT6 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS231669">
        <property type="protein sequence ID" value="ESU16548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318810.1">
        <property type="nucleotide sequence ID" value="XM_011320508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4HYQ4"/>
    <dbReference type="SMR" id="Q4HYQ4"/>
    <dbReference type="FunCoup" id="Q4HYQ4">
        <property type="interactions" value="1222"/>
    </dbReference>
    <dbReference type="STRING" id="229533.Q4HYQ4"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T06803">
        <property type="protein sequence ID" value="FGRAMPH1_01T06803-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G06803"/>
    </dbReference>
    <dbReference type="GeneID" id="23556830"/>
    <dbReference type="KEGG" id="fgr:FGSG_09904"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06803"/>
    <dbReference type="eggNOG" id="KOG1856">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001680_0_1_1"/>
    <dbReference type="InParanoid" id="Q4HYQ4"/>
    <dbReference type="OrthoDB" id="995477at2759"/>
    <dbReference type="PHI-base" id="PHI:1601"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001073">
        <property type="term" value="F:transcription antitermination factor activity, DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00164">
        <property type="entry name" value="S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.140:FF:000007">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000065">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2740:FF:000002">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.650:FF:000004">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000056">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.850:FF:000001">
        <property type="entry name" value="Transcription elongation factor spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049540">
        <property type="entry name" value="Spt6-like_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028083">
        <property type="entry name" value="Spt6_acidic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
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        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SH2_2"/>
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    </dbReference>
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        <property type="entry name" value="SPT6_acidic"/>
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    <dbReference type="Pfam" id="PF21710">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036947">
        <property type="entry name" value="Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0727">SH2 domain</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <feature type="chain" id="PRO_0000238576" description="Transcription elongation factor SPT6">
        <location>
            <begin position="1"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="1101"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="domain" description="SH2">
        <location>
            <begin position="1213"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="75"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P23615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="1408" mass="162213" checksum="8CB31D52E5DFE1BF" modified="2005-08-16" version="1">MSNSMRDLISGEAELDDEEEDESFDERGGQRRHKNAVEDSSEEEEDDDDEEEARKVREGFIVDEDEDEDEGGESDADVRPLHKRKREHRDREEEAQLDEDDLDLIGEQFGERPKPTTQSKFKRLKRGTRDEDRGNQRRGLDDIFSDEEDDAGEQRAYNNRSSYRQADEFDDFIEEDFPDDPEELEQQREDAEVARPRDRVIGNIADTANLDKDALDDMEAIFGNGEDYDWALQMEEEEEDREREEQAIELKDVFEPSQLKEKLLTDEDNEIRFTDEPERFQIDRKTFKSLQLTAEQFKEEARWITNQLWPKKGLASDLQSPFGKAVGKVLEFFIVDEVEVPYVFQHRKDYLLHTRKTRNPNRDDPDAPEYVISADKLLNQDDLWKILELDIKFRSFVDKRNALEKTVDNLKGMEIHDAMVDEMIPEATTMEELQDLQDYLHFQYGQQLKDLAALAGNLSLTKRPGSKSNLLERVRQGKAYGFVRAYGISADQLAKNALRHGKKVTPDDDAQYPMDLADSLIDDVFSTGDQVISAARQMYSEELFASPRMRKHFRNSYYQAAEISCRRTEKGLRRIDDSHPYYEIKYLQNQAIADLVHQPELFLKMMKAEEEGLVTIKLDMPARYDFRQHLYQEFESENFSDRAEQWREERKKVLDLAYPKLEKIIAKNVKEVIRTFCQDEVLKMCREEYAKRLDQAPYKPKGMILGTTPRVLVLSNGMSDPARDPICWAWVEEDGRVIEQGKLGNLARDERQREEFEELVKRRRPDVIGVSGWSAETTKLVRDLEGLVNEKGLMGPEFEDPDTNDYRTEPLEVVVVNDEVARLYKDSPRALAEHPSLNPITRYCVALARYMQNPMKEYAALGKDVSSLSYHPCQNLLPADKLAKYLDSAMVDMVNLCGVDINEAMNDTYTANLLPYVSGLGPRKATSVIKAINANGGAVGTRDELVGDPDSGKLPVVGPRVWNNCASFLFIEYEATNPSSDPLDNTRVHPEDYELGRKMAADALELDEEDVKGETDENGPGAIVRKLFKMDEQDKVNELVLEEYAEQLERNYSQRKRATLETIRAELQAPYEELRRNFALLSASEIFTMFTGETKHTLCEGMIVPVNVRVVKDDFAIVKLDCGIEGRVEGHEVSHRSSIKEVLSSGQTSQAKILDINYKDFMAKLSMREDALRIPYKRPINLGRDGWDYVLEAADKEELREKDKTTGRTQRVVKHPNFKPFNGLQAEEYLGSQPNGEVVIRPSSKGNDHLAVTWKVADGVFQHIDVLEMQKETEFAVGKLLRVGGKYTYTDLDELIVEHVKAMARKVEELMRHDKYQNRSRGETEKWLTTYIDANPNRSTYAFCIDTKHPGYFWLCFKASRAAKVIALPVRAIPQGFELKGYQYPDMRALCNGFKLRYQNEFSKMGQR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-13" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q4I877</accession>
    <accession>A0A0E0S918</accession>
    <accession>V6RL98</accession>
    <name>NDE1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName>Nuclear distribution protein nudE homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">NDE1</name>
        <name type="ORF">FGRRES_06581</name>
        <name type="ORF">FGSG_06581</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for nuclear migration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates. Interacts with PAC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
            <location>Cytoskeleton</location>
        </subcellularLocation>
        <text evidence="1">Localizes to the plus ends of microtubules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nudE family.</text>
    </comment>
    <dbReference type="EMBL" id="DS231666">
        <property type="protein sequence ID" value="ESU12690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF82931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326197.1">
        <property type="nucleotide sequence ID" value="XM_011327895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4I877"/>
    <dbReference type="SMR" id="Q4I877"/>
    <dbReference type="STRING" id="229533.Q4I877"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T22637">
        <property type="protein sequence ID" value="FGRAMPH1_01T22637-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G22637"/>
    </dbReference>
    <dbReference type="GeneID" id="23553708"/>
    <dbReference type="KEGG" id="fgr:FGSG_06581"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22637"/>
    <dbReference type="eggNOG" id="KOG1853">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034391_0_0_1"/>
    <dbReference type="InParanoid" id="Q4I877"/>
    <dbReference type="OrthoDB" id="5877028at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0493">Microtubule</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000240225" description="Nuclear distribution protein nudE homolog 1">
        <location>
            <begin position="1"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="358"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="14"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="453"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="583" mass="63650" checksum="74D86E408DD12597" modified="2005-08-16" version="1">MASEPPSSPPGAGATLEDTLGWYKSQYEQLESELAEFRDSSRELEQELEKDIERAEKQERHHQEKAETLGFEVEEWKRKYRESKTEASASQNALEKEITTLRDTNRTLQLKLRDIEVANDDFERQARNTTSSLEDMESKYNQAIERAVMMEEEIKIGEQEREQLRIESQRLREELGDLKIEAELLQDKFKKQESRHLSTISTDLSVLASPTFDGHPASPGSTASSPLITTPTDSKSMTEDGDTLSELPDPPSPPMSDVSAPLPKVAASRPSAHRRTVSRSRLPSTDISTTPLPRSKPPTATTRAPGSRISTGGTTTMRTPAQRAVGPRSASNKLPTSNSLTHIRTLTAQMQRLEARVHSVRSKLPGPTRTPPRASPRTNVYSATNMPASITIRSRKRTSGSAASSVTGDDPTPTNIPTSTPKGSHVPRLSTSGVSRLSFGPLPNRGGPDEISRPSSRASTSYATSYARPPSRAAGEGIPRPISRASLTGVRTPMGRSRSSMGFHGHSASISSHLDLEEQDEGEFRTPSRRGTYSSQGGEVSGSGIPMPATRRRSGSRRISASTMRSSVSGPPRKQLSDLGETY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q4I963</accession>
    <accession>A0A098E4Q7</accession>
    <accession>A0A0E0SP10</accession>
    <accession>A0A1I9FVL7</accession>
    <accession>I1RQA4</accession>
    <accession>V6REA7</accession>
    <name>COFI_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName>Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">COF1</name>
        <name type="ORF">FGRAMPH1_01T19853</name>
        <name type="ORF">FGRRES_06245</name>
        <name type="ORF">FGSG_06245</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. Binding to F-actin is regulated by tropomyosin. It is the major component of intranuclear and cytoplasmic actin rods. Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends. In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments. Involved in the maintenance of the contractile ring once formed. In association with profilin and capping protein, has a role in the mitotic reorganization of the actin cytoskeleton.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
        <text evidence="1">Throughout the cytoplasm (but not on the cytoplasmic cables) and major component of the cortical actin cytoskeleton.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CEF88173" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="DS231665">
        <property type="protein sequence ID" value="ESU12317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88173.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324893.1">
        <property type="nucleotide sequence ID" value="XM_011326591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4I963"/>
    <dbReference type="SMR" id="Q4I963"/>
    <dbReference type="FunCoup" id="Q4I963">
        <property type="interactions" value="811"/>
    </dbReference>
    <dbReference type="STRING" id="229533.Q4I963"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T19853">
        <property type="protein sequence ID" value="FGRAMPH1_01T19853-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G19853"/>
    </dbReference>
    <dbReference type="GeneID" id="23553381"/>
    <dbReference type="KEGG" id="fgr:FGSG_06245"/>
    <dbReference type="eggNOG" id="KOG1735">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094004_4_0_1"/>
    <dbReference type="InParanoid" id="Q4I963"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00006">
        <property type="entry name" value="COFILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0009">Actin-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000255625" description="Cofilin">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="2">
        <location>
            <begin position="4"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="153" mass="16969" checksum="3711C4C9D8718DFA" modified="2013-01-09" version="2">MSQSGATVSQDCITAFNDLKLNKKYKFIVYKLSDDYKEIVIDKASESRDWEDFRETLVNATAKSRTGAVGKGPRYAVYDFEYNLASGDGIRNKITFIAWSPDDAGIQPKMIYASSKEALKRSLTGIATELQANDTDDIEYDSILKTVSKGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>V6R5G9</accession>
    <name>V6R5G9_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable glucan endo-1,3-beta-glucosidase eglC</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Endo-1,3-beta-glucanase eglC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Laminarinase eglC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">FG03529.1</name>
        <name evidence="24" type="ORF">FGRAMPH1_01T13095</name>
    </gene>
    <organism evidence="24 26">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="25">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="25 26" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="26">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="25">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="24 26" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="24">PH-1</strain>
        </source>
    </reference>
    <reference evidence="25" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_011323878.1"/>
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        <property type="interactions" value="418"/>
    </dbReference>
    <dbReference type="STRING" id="229533.V6R5G9"/>
    <dbReference type="EnsemblFungi" id="CEF78351">
        <property type="protein sequence ID" value="CEF78351"/>
        <property type="gene ID" value="FGRRES_03529"/>
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    <dbReference type="KEGG" id="fgr:FGSG_03529"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13095"/>
    <dbReference type="eggNOG" id="ENOG502QQE6">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_028820_2_1_1"/>
    <dbReference type="InParanoid" id="V6R5G9"/>
    <dbReference type="OrthoDB" id="1293114at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:polysaccharide catabolic process"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Beta-glucan_modifiers"/>
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        <property type="entry name" value="GH"/>
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    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
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        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF13">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE EGLC-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0134">Cell wall</keyword>
    <keyword evidence="17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010153389" description="Probable glucan endo-1,3-beta-glucosidase eglC" evidence="23">
        <location>
            <begin position="23"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CEF78351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="301" mass="33459" checksum="BC5EF438F393E724" modified="2014-02-19" version="1">MKFFSTLSTLAVALMMTGEAVAGTYKGFSMGANRADGVCKWEADWKKDFQAIKSWNKGFNAVRLYSASDCNTLVKAVPAAKATGMKILVGIWSTDDAHFGRDKAALLKAIKQHGTGWIAAISVGSEDLYRKDISPQKLAQQIYDVRGMVHQYNKALKVGHTDTWTAWVDGTNDVVTKACDIAITNGFPYWQGVPIKDALRLKTFQNSYWNVKKHVQAVNSKATVWVGETGWPTKGPNYQKAAATTASLQQYYNNVGCWLWQQKDASGFWFTAFDTPAQTTEVEKYFGVANQDRKLKFSLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>V6REE9</accession>
    <name>V6REE9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG06847.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T23321</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326500.1">
        <property type="nucleotide sequence ID" value="XM_011328198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6REE9"/>
    <dbReference type="SMR" id="V6REE9"/>
    <dbReference type="FunCoup" id="V6REE9">
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    </dbReference>
    <dbReference type="STRING" id="229533.V6REE9"/>
    <dbReference type="EnsemblFungi" id="CEF83475">
        <property type="protein sequence ID" value="CEF83475"/>
        <property type="gene ID" value="FGRRES_06847"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06847"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23321"/>
    <dbReference type="eggNOG" id="KOG0841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058290_0_0_1"/>
    <dbReference type="InParanoid" id="V6REE9"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd11309">
        <property type="entry name" value="14-3-3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="5">
        <location>
            <begin position="3"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF83475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="272" mass="30196" checksum="EEFF1CCCEB7D5BFA" modified="2014-02-19" version="1">MGHEDAVYLAKLAEQAERYEEMVENMKIVAGEDRDLTVEERNLLSVAYKNVIGARRASWRIVTSIEQKEESKGNSSQVTLIKEYRQKIEAELAKICEDILEVLDQHLIPSAKSGESKVFYHKMKGDYHRYLAEFAIGDRRKDSADKSLEAYKAATEVAQTELPPTHPIRLGLALNFSVFYYEILNAPDQACHLAKQAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSSEAETSAAGQAEAPKEDAPAAATAEDAPAAPAAAEEPKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>V6RKE4</accession>
    <name>V6RKE4_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG06317.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T20021</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324971.1">
        <property type="nucleotide sequence ID" value="XM_011326669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6RKE4"/>
    <dbReference type="FunCoup" id="V6RKE4">
        <property type="interactions" value="869"/>
    </dbReference>
    <dbReference type="STRING" id="229533.V6RKE4"/>
    <dbReference type="EnsemblFungi" id="CEF87070">
        <property type="protein sequence ID" value="CEF87070"/>
        <property type="gene ID" value="FGRRES_06317"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06317"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20021"/>
    <dbReference type="eggNOG" id="KOG1061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006320_4_0_1"/>
    <dbReference type="InParanoid" id="V6RKE4"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000058">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="641"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="658"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="718"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF87070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="747" mass="81877" checksum="DA0B4108A88A2EE2" modified="2014-02-19" version="1">MAVNRIKGAFAVPRKGETFELRAGLVSQYAYERKESIQKTIMAMTLGKDVSALFPDVLKNIATGDLDQKKLVYLYLMNYAKSHPDLCILAVNTFVQDSEDPNPLIRALAIRTMGCIRVDKMVDYMEEPLRKTLRDESPYVRKTAAICVAKLFDLNPQMCIENGFLEALQELIGDPNPMVVANSVTALSEITETAPETRALIVTPVTLKKLLMALNECTEWGRVTILTTLADYSASDQKESEHICERVAPQFQHVNPSVVLAAVKVVFIHMKALNPDSVRSYLKKMAPPLVTLVASQPEVQYVALRNIDLLLQAKPDILSKEMRVFFCKYTDPPYVKLQKLEIMVRIANEHNYEQLLAELKEYALEVDMDFVRRAVKAIGQVAIKIENAAEKCVAALEDLISTKVNYVVQEVIVVIKDILRKYPGYEGVIPTLCKHIDELDEPTARGSLIWIVGEYAEKINNADEILESFVESFMEEFTQTQLQILTAVVKLFLKKPGSNQNLVQKVLQAATAENDNPDIRDRAYVYWRLLSSDPEVAKNIVLSQKPTITTTMTSLPPALLEQLLTELSTLASVYHKPPESFVGKGRFGADEIQRAAIQEQRQNAAENPIAASVATASSNGSGGGAQNNIENLLDIDFDGAAPASHEQNSASATPDRVASPSASGPSGAMADMMSMFDAPAQPSGVGAPTSAAGPSNNMNDLMNGFEGLNFGGATTSEPLPAAMQLQQAQGGAPQQPKKDSDDLLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D8P9</accession>
    <accession>A0A0E0RU95</accession>
    <name>A0A098D8P9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T06031</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D8P9"/>
    <dbReference type="EnsemblFungi" id="CEF74820">
        <property type="protein sequence ID" value="CEF74820"/>
        <property type="gene ID" value="FGRRES_15145"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06031"/>
    <dbReference type="InParanoid" id="A0A098D8P9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF74820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="59" mass="6694" checksum="1763C8B432B88A7B" modified="2015-01-07" version="1">MTVPTLVMPLLETLFVEWPPVCHTQSHTAYTKGSQLVIPIRIKLRCYFEEAPSEAEAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DAC7</accession>
    <accession>A0A0E0RW15</accession>
    <name>A0A098DAC7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T07273</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DAC7"/>
    <dbReference type="EnsemblFungi" id="CEF75440">
        <property type="protein sequence ID" value="CEF75440"/>
        <property type="gene ID" value="FGRRES_20090"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07273"/>
    <dbReference type="InParanoid" id="A0A098DAC7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF75440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="45" mass="5206" checksum="05C5B964787C228B" modified="2015-01-07" version="1">MCSLVQSRTVLASPHTSIILRFDTDNNIYRVKLKQPSNLVIYTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DAG7</accession>
    <accession>A0A0E0RXI3</accession>
    <name>A0A098DAG7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T08309</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DAG7"/>
    <dbReference type="EnsemblFungi" id="CEF75958">
        <property type="protein sequence ID" value="CEF75958"/>
        <property type="gene ID" value="FGRRES_15611"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08309"/>
    <dbReference type="InParanoid" id="A0A098DAG7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010018624" evidence="2">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF75958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="53" mass="5687" checksum="71DE220CB4A539C5" modified="2015-01-07" version="1">MTGLLACLLVCLFASGRRKSIPPFRPRHKQAQHTPAPGAQTALQGRAQGYRAG</sequence>
</entry>
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    <accession>A0A098DCN8</accession>
    <accession>A0A0E0RY87</accession>
    <name>A0A098DCN8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
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        <name evidence="2" type="primary">FG07982.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T08819</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DCN8"/>
    <dbReference type="EnsemblFungi" id="CEF76212">
        <property type="protein sequence ID" value="CEF76212"/>
        <property type="gene ID" value="FGRRES_07982_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08819"/>
    <dbReference type="InParanoid" id="A0A098DCN8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF76212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="476" mass="54117" checksum="B462632525F2C81A" modified="2015-01-07" version="1">MALLKREWPSWLTETRDPARVWVRDRFLIPLYEEIREKLPEYTPATLLSSADRIKITALRHYKQTVRPSHEAARIDIRIDFPNNRTPFLDLSIVCDRTAGEAATDKRGAMIVLGVKYPALDRVVFYNPSEADEQLLKDKAAELSHSTADVSGQYFNLLFLAFVLQTLSSRNPDYHLYSTMCYWYAGSTLDCLSLALNKAKQEAESHITGGETRENSDHRGRATFMESKWLKFGCFYKSQVPDALDTLTLRNSEAGTPTEEFMGVVTEAETKTNTFRASLVCGDEDLTLPEHRQEFLRRYLVVDVPIEVGTKDDSYRLSPKPSPGFILMDELALGDDNVNTGMATEARELFYKENRFLVSLKALDAFWNGRYQRYELGDLVKSSIQHIIIAISTDDDQNLYPVMDALQDLDPSAKVRIVLLGFGMSPESEGAFSRVSEDISSWVNSFSQRFSNFKMHKQLLPEDADNHVVTEILNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DDX3</accession>
    <accession>A0A0E0S0Y3</accession>
    <name>A0A098DDX3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T10711</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DDX3"/>
    <dbReference type="EnsemblFungi" id="CEF77158">
        <property type="protein sequence ID" value="CEF77158"/>
        <property type="gene ID" value="FGRRES_15508_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10711"/>
    <dbReference type="InParanoid" id="A0A098DDX3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="63"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="63" mass="6767" checksum="D912BD6A3EE87573" modified="2015-01-07" version="1">MSEKEAHENIGSKFGAEALFSLPPSLSVSVPVSPLTIRASDQTNGRANLTNKENNGLDLTQPW</sequence>
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    <accession>A0A0E0S2A4</accession>
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        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DF94"/>
    <dbReference type="STRING" id="229533.A0A098DF94"/>
    <dbReference type="EnsemblFungi" id="CEF77629">
        <property type="protein sequence ID" value="CEF77629"/>
        <property type="gene ID" value="FGRRES_02934_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11651"/>
    <dbReference type="eggNOG" id="ENOG502SJQV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DF94"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="597" mass="69144" checksum="41EFD85155A1F918" modified="2015-01-07" version="1">MASSNSSPGMGSFQLLSPKVRSMIFSYLDRGDMTSLRATCSTLERVVPCNIHRVFISVNSLNIQVFRAIADSELHRHKITEIVWDDARLPEVPEYEETTSSEDDDDGDEEEKDDTDNNVYDDWDADDYDDYNDCDDDDDNESLCSSMPEWFTTRCLDGGPGNRHKVHYSNSIINKSWNYYEALLRDQRKIMQSNADIEAFKYGLQRFTHLRRVTITPSTHGRQNQPLFRTPMIRSFPFDFVYPSPRPWPYTGFDIEYVDAPWVPNDGHSVEYAYEDCDCRFLSLTALHIKYRDKLCSCHVGKLSASVHDEYISNWRGFSLVTRALVECEQDHHVIELIIGGREIWTGVNCHVFDQKCQEYDDLVSLLKQPGFHRLDLDLNTFMIQRDGVGWKSYRSGLLREALAQAKNLRYISLRTTTDTSDGKCWYIDPKDEFKKIFPLEIIFPFDQWPKLQHFGISNMLVTSSNLVSLLAVLPPLRSVELSNLGFAQGSWWELLHEMRTKLDWRMRPVEERPQVHMTVADLYFDDLEIGFYVDIDDTVASFMYGSGKNPFRKQPAQWLAAHGECIDNIPRGTVGTKRDFLDPHFSAPYEFAVEDR</sequence>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DFK8"/>
    <dbReference type="EnsemblFungi" id="CEF77250">
        <property type="protein sequence ID" value="CEF77250"/>
        <property type="gene ID" value="FGRRES_20145"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10895"/>
    <dbReference type="InParanoid" id="A0A098DFK8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF77250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="66" mass="7211" checksum="C82F6EDFB83B733A" modified="2015-01-07" version="1">MALNRLSPNPSYPALRDMCHREALVTHASGQTNQQVSGVGVRNHTVQAILEAERVSKAQSEILVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DHI7</accession>
    <accession>A0A0E0S322</accession>
    <name>A0A098DHI7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T12187</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DHI7"/>
    <dbReference type="STRING" id="229533.A0A098DHI7"/>
    <dbReference type="EnsemblFungi" id="CEF77897">
        <property type="protein sequence ID" value="CEF77897"/>
        <property type="gene ID" value="FGRRES_20168"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12187"/>
    <dbReference type="InParanoid" id="A0A098DHI7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF27">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF77897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="543" mass="61916" checksum="824BF458AE54A690" modified="2015-01-07" version="1">MSLLRFRPHFHPQFPITFFVLLNRPMVLPTARYGATKQTSMSKKKSKCTGEKPTCSFCQRLNQDCTYKTTEPKRTNTKRSGRVNKNAYPSDLPDRFQLLESQVKGIYELLERRTETVSRSSPNTSARPISVDSYESATSMSPEIISETIPEATFSPDKVLFPPPMPLIISSRYIALDIIFSHCFLHSPYDIAGMPSIGDNKLKLSNSMLLPPNKQSPVLLRRVSRGWKLSNLFACLSWLMSRAWMTIGTLSRLEALRKISQPALIESLSDLEASLGCHWTVFLLEQTFTPLERSSIQDDNEPRYPTSAPIPPSLPPVSDGEYPPDLFSEDASEDLGITAYYVKILGIWGNLSSYLHQIRIGKVGNAWSPGSMHYTICAQLYEYDSKTPHIHLLRSVHFTKRQSHDLIERREYWIPWVLQQVTSHATNAILNHPFIHLVAMRDGMNGLPPRQFLQQTVDLTLYHSAWVFKFLRFCDENNIGIYDPLVGHLVAVVATIPWLFQRAIDQKIALKAKDDFAWCKEFLQSLSTTWPHIGHKVSLKFLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DI45</accession>
    <accession>A0A0E0S553</accession>
    <name>A0A098DI45_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T13651</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DI45"/>
    <dbReference type="EnsemblFungi" id="CEF78628">
        <property type="protein sequence ID" value="CEF78628"/>
        <property type="gene ID" value="FGRRES_03763_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13651"/>
    <dbReference type="InParanoid" id="A0A098DI45"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF78628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="179" mass="20423" checksum="82C3D3B9CB22D849" modified="2015-01-07" version="1">MSPFGQILTKDETTPLGIHGRRSASIHGWIFEVSHAIQNRPLSPLDTSDEPKSPSSLTVEIQFEDLMAEYAEVLERKEKLEDKIADLYYAQQKNGDITFPASWSSSAFTSMTKRQEASNHKGKPTAAKKQELPSTSSDYKEFSPPDQVQERVKDRKSRKPKTEEEKNRHINKVFIRNCL</sequence>
</entry>
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    <accession>A0A098DI50</accession>
    <accession>A0A0E0S3M2</accession>
    <name>A0A098DI50_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG03317.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T12589</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nucleoside permease that transports adenosine and guanosine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NUP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DI50"/>
    <dbReference type="STRING" id="229533.A0A098DI50"/>
    <dbReference type="EnsemblFungi" id="CEF78097">
        <property type="protein sequence ID" value="CEF78097"/>
        <property type="gene ID" value="FGRRES_16293"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12589"/>
    <dbReference type="eggNOG" id="ENOG502QQPU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DI50"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009486">
        <property type="entry name" value="Pur_nuclsid_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643:SF1">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06516">
        <property type="entry name" value="NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013171">
        <property type="entry name" value="Pur_nuclsid_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR013171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF78097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="372" mass="40416" checksum="D22B44935AA56627" modified="2015-01-07" version="1">MSEQQSNQRGLAATQAQGEKISPKVLLIAMFYEESRNWLDPSSALQFSRKIRVPGLARGYEDIHVTEDGDVALLVVGTALINASLSISALLTSPVFDLTKSYFILTGIAGVNPKRTTIGSVAFAKFAVQVDLQLGFDAREVPSEWGSGYVPMGADKPDQFPGIVHGSEVFELNSALRDYALSVAKGVNLQDSPVAAEHRALWKNSPEGIFDAATQKPSVLEGDVLSSNTFWHGHRISEAMEKVTKVYTAGQAEYTMTAQEDNALLAGLLNAALQGKVDFSRILLIRSASNFDRGHEDKPHKLPFVMDKGGLGPSTRNLYLTALKVIEGILKEWSTRFEAGIAPQNYIGDIFASLGGKPGFGDKYDIDQVRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DL93</accession>
    <accession>A0A0E0S884</accession>
    <name>A0A098DL93_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T15821</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DL93"/>
    <dbReference type="EnsemblFungi" id="CEF79709">
        <property type="protein sequence ID" value="CEF79709"/>
        <property type="gene ID" value="FGRRES_15255"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15821"/>
    <dbReference type="InParanoid" id="A0A098DL93"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF79709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="59" mass="6961" checksum="B0E5FE1F83D8CD81" modified="2015-01-07" version="1">MPAGLPAEYRAIVKGLSVVKLNELAQRWQYKRDEKIRSRDTAQEYFTNEATRKHQPWGQ</sequence>
</entry>
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    <accession>A0A098DUF3</accession>
    <accession>A0A0E0SEX1</accession>
    <name>A0A098DUF3_GIBZE</name>
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        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T24037</name>
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    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DUF3"/>
    <dbReference type="EnsemblFungi" id="CEF84984">
        <property type="protein sequence ID" value="CEF84984"/>
        <property type="gene ID" value="FGRRES_13066"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24037"/>
    <dbReference type="InParanoid" id="A0A098DUF3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF84984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="127" mass="14387" checksum="D3E630797BDC9146" modified="2015-01-07" version="1">MSPSLRSVGPIHLRFERMNAVEVAKTAAGVVRSFDIRRFQLDTYTTANRDIWLKPQAKLNGLAHAESRSGRFSELRLCGSVLGSISTMIYHPGRGKEAFPVVRKRRGFMIKREVLTGEGWNQLRLDD</sequence>
</entry>
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    <accession>A0A098DVC0</accession>
    <accession>A0A0E0SFU9</accession>
    <name>A0A098DVC0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG06854.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T23337</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A098DVC0"/>
    <dbReference type="EnsemblFungi" id="CEF85312">
        <property type="protein sequence ID" value="CEF85312"/>
        <property type="gene ID" value="FGRRES_16730"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23337"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DVC0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
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    <dbReference type="PANTHER" id="PTHR24198:SF193">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
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            <begin position="675"/>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    <accession>A0A098E1Z3</accession>
    <accession>A0A0E0SMF4</accession>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098E1Z3"/>
    <dbReference type="EnsemblFungi" id="CEF87617">
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        <property type="gene ID" value="FGRRES_20320"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21887"/>
    <dbReference type="InParanoid" id="A0A098E1Z3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF87617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="130" mass="15190" checksum="1F4439B66268E303" modified="2015-01-07" version="1">MSLVAIFERDYGWLLFYRTSVMDERRGDTQHRWIQARRGVEFMQGLSLGLSLIMRKVSSGAEVDERAANSPVLWHDYINEQSSRSARNTTQQKKASTWPGMGRNPYIWQYMAHIDDSAHEFRIGSFISDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RL94</accession>
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            <fullName evidence="1">Chromosome 1, complete genome</fullName>
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    <gene>
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    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RL94"/>
    <dbReference type="EnsemblFungi" id="CEF72019">
        <property type="protein sequence ID" value="CEF72019"/>
        <property type="gene ID" value="FGRRES_15052"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00437"/>
    <dbReference type="InParanoid" id="A0A0E0RL94"/>
    <dbReference type="Proteomes" id="UP000070720">
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF72019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="85" mass="9575" checksum="681B82ADDBEFF01F" modified="2016-04-13" version="1">MPSDLGQDQWRCDEWVYDRRQQVVPCNTIHSMASKYCRRCDKPRGAGAKALKNGVEIGMLMSVQLGEEDWALTPATSERGTHGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RRD5</accession>
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            <fullName evidence="1">Chromosome 1, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RRD5"/>
    <dbReference type="EnsemblFungi" id="CEF73810">
        <property type="protein sequence ID" value="CEF73810"/>
        <property type="gene ID" value="FGRRES_20054"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04007"/>
    <dbReference type="InParanoid" id="A0A0E0RRD5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF73810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="59" mass="6220" checksum="1D9BF2D8FBA5F79D" modified="2016-04-13" version="1">MTGRTASTKAQRVAAKQTAARTGRIVRHFGGDFGIRSQPTTYWDKGGKTLGAHGVTAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RZM5</accession>
    <name>A0A0E0RZM5_GIBZE</name>
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        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
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        <name evidence="5" type="primary">FG08371.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T09795</name>
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    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0E0RZM5"/>
    <dbReference type="STRING" id="229533.A0A0E0RZM5"/>
    <dbReference type="EnsemblFungi" id="CEF76700">
        <property type="protein sequence ID" value="CEF76700"/>
        <property type="gene ID" value="FGRRES_17047"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09795"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A0E0RZM5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Epimerase_deHydtase"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="7"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF76700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="341" mass="36153" checksum="EC4963475C9FA7D8" modified="2016-04-13" version="1">MSDKPIVLVTGANGYIAGSVVEAFLKAGYAVRGTVRSKASGDSLVKALSSYGSDLEIVQVPDIVAPGAFDTAVKGVHAILHLAAGVSLSFTDPDPVLEVAIKGTESVLESALTEPSIKSVVLMSSIAAISATGNPSSNRVTEADWNDAALDAVKKLGKASPSPLIYVASKVAGERAFWKFRDEKKPSFTMTALNPTFVMGPQPGLESISKIGGTTAFIWQVFSGQDIPKPIVPNPSFVDARDIARVAVFSVDHPEKANGERFLLTAGLVPPQAAADVLRKAYPDRQDIIKVGQPGEGYYPGYAFPEEKILDASKTIKLTGQDFYPVEKSIIDTAKSLEKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0S6I6</accession>
    <name>A0A0E0S6I6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG04153.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T14617</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0S6I6"/>
    <dbReference type="STRING" id="229533.A0A0E0S6I6"/>
    <dbReference type="EnsemblFungi" id="CEF79111">
        <property type="protein sequence ID" value="CEF79111"/>
        <property type="gene ID" value="FGRRES_16143"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14617"/>
    <dbReference type="InParanoid" id="A0A0E0S6I6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="551"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF79111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="605" mass="68583" checksum="FB2FA37D1C2A07DF" modified="2016-04-13" version="1">MSISRDFALPAEQDSSMQDDIELHSRQSQSSNTNVSDEKAEQHVRYNLTLNTQNLSPPPAEPVRPVRSDTEVHREMNFSPSILRRRLTRVPTFKTVEDYDEFETTFGDRPGWQPGSEPGYDPMLPDGGHASMPALHAACEISVIDFAQDNMVKRHFDNASFIAFLDEPKEEWAKCRWINVNGLSWDVIQAIGSKKGLHKLALEDLMQIRNRTKADWYPNHAFIVMTLQKLVHLVDDEDDTTDTSSTYSSKTVGRLRGSVRQLWKSRKTADPEKNFESSLRAREVASDLQETGMIRTLQRYHASGNEARTEFMESHSSLAPYQMAVSAEQVSIFLTSDNTVISFFEVSAGDIERPIVTRLSTPGTILRESNDASLLCQGIIDAIIDLAIPLTAIYTDIIADIELDVLTAPSISQSKKLYVCISEINKMLSFLNPIDNLVNVLRDHKTSMTHEVAMQELENPSTGVIVTPMTHTYLGDVLDHCIMITEALQQLKQSSDNLINLIFNTISAHQNESMKQLTTVTIIFLPLTFITGFFGQNFAAEGFPEIHHGIWYFWACAVPTVVATILILMREMIYNWLIRLVQRRHILTLRKKKKRSKQQKIKLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SAB7</accession>
    <name>A0A0E0SAB7_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin prenyltransferase PAD1, mitochondrial</fullName>
            <ecNumber evidence="6">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG06435.1</name>
        <name evidence="6" type="synonym">PAD1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T22273</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for the ferulic acid decarboxylase FDC1. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dimethylallyl phosphate + FMNH2 = prenylated FMNH2 + phosphate</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Oligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="6"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SAB7"/>
    <dbReference type="FunCoup" id="A0A0E0SAB7">
        <property type="interactions" value="213"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A0E0SAB7"/>
    <dbReference type="EnsemblFungi" id="CEF83380">
        <property type="protein sequence ID" value="CEF83380"/>
        <property type="gene ID" value="FGRRES_16656"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22273"/>
    <dbReference type="eggNOG" id="ENOG502QWR5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0SAB7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1950:FF:000001">
        <property type="entry name" value="Flavin prenyltransferase UbiX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004685">
        <property type="entry name" value="PRK06029.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="7">
        <location>
            <begin position="67"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="74"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="151"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF83380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="257" mass="28384" checksum="71D7EABF80005DFA" modified="2016-04-13" version="1">MKAVSFATRQLLGVSSTKVTFYHPTHPIQRPYVRLFSTSQSYLSWGGARDQVYENALPSLESTRPTRIVVGITGATGAPYAIRILTLLHHLGVETHLIISKWALATLKYETSMSEADIRGLASRSYTAKDLSAPIASGSFQHDGMMIVPCSMKTLAAVRSGYCDDLISRAADVTLKEDRILLLAIRETPLSSIHLENMLALRRANAIIFPPVPAFYTRPGGIDDIVDQSAGRMLDMMGIFTDGFERWEGFKKAQTEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SCF1</accession>
    <name>A0A0E0SCF1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T24997</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SCF1"/>
    <dbReference type="EnsemblFungi" id="CEF84114">
        <property type="protein sequence ID" value="CEF84114"/>
        <property type="gene ID" value="FGRRES_20372"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24997"/>
    <dbReference type="InParanoid" id="A0A0E0SCF1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF84114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="62" mass="6882" checksum="37C05BFC85C772F3" modified="2016-04-13" version="1">MSKAEAPEKVLNWIDRVERQSGGLKVQTLGFDNAAEFHSEVLDIGLNMRGNGRVERAGRLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SCV7</accession>
    <name>A0A0E0SCV7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T23765</name>
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    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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    <dbReference type="AlphaFoldDB" id="A0A0E0SCV7"/>
    <dbReference type="EnsemblFungi" id="CEF84270">
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        <property type="gene ID" value="FGRRES_13042"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23765"/>
    <dbReference type="InParanoid" id="A0A0E0SCV7"/>
    <dbReference type="Proteomes" id="UP000070720">
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        <source>
            <dbReference type="EMBL" id="CEF84270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0E0SFL4"/>
    <dbReference type="STRING" id="229533.A0A0E0SFL4"/>
    <dbReference type="EnsemblFungi" id="CEF85227">
        <property type="protein sequence ID" value="CEF85227"/>
        <property type="gene ID" value="FGRRES_17271"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26281"/>
    <dbReference type="eggNOG" id="KOG4733">
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF85227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="536" mass="58211" checksum="1D6B667811B375B9" modified="2016-04-13" version="1">MEQNTAAAPFLSTHSDRRPQHLAIPGSADHNALLSQFHGLSLAGMSMSAPQAASVPMQPPYMVAPDGLILAPMQGAQSLAMNHPGELNYSGYQMNGGYAGPYALPGSLMPFTPARANAGNPRADRTQPEVPGLENRRGSYSTTESAPATPFYGSWPPREHGPRVHSDRSAYTTPSPHQLMVTHHAEAANKPKPSPASERVLDELLEKNPRIPGAVPAVFTPAGHMKSLEQSLENRIPGNRNVYIRGLHPTTDDELLFHYAARFGNVETSKAIIDTATGACKGFGFAKFYDVSESEMCIRGFHRLGYEVGFARESFNSRLKAEGDELSTNLYISNLPKSLTEVELGLIFQGYTILSSKILRDSMGNSRGVGFARFENRDVCDDVVEKFHGRPVGEEGLLMNIRYADTPAQKELKRVTAERRQFRTNEYNIGAYGTPLVGYGGSMFPHHVQNRRAAIPITRPPMSPELTASDTNDEHRRAGLQRQSTGTAPSLPADEAVATPTSSECGENTTVHAETVAVGATFDASPSIKKEVKKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SH09</accession>
    <name>A0A0E0SH09_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG06654.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T22841</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WHI5/NRM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SH09"/>
    <dbReference type="STRING" id="229533.A0A0E0SH09"/>
    <dbReference type="EnsemblFungi" id="CEF85722">
        <property type="protein sequence ID" value="CEF85722"/>
        <property type="gene ID" value="FGRRES_16696"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22841"/>
    <dbReference type="eggNOG" id="ENOG502T64N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0SH09"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013734">
        <property type="entry name" value="TF_Nrm1/Whi5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08528">
        <property type="entry name" value="Whi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="133"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF85722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="199" mass="21248" checksum="9A83622B3FEA6AFC" modified="2016-04-13" version="1">MEPSTTSSSTSSPAKRRALAPLDANALAAPKNLFKPTLGHSPVKMAIEGRKRLLDIEGSAPAAKKACLGRDEDASVRSASPDVSSVFDTSANDASWVTTTSDHDTAPPAATRAETLRLRLSLANYKVRTGQTTVPLSELQQRPLPRESPRVVRVQSPLSPVAPAPVQEEVEAAAETRSRRDSIDSQATEIVPSDDEEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SIX2</accession>
    <name>A0A0E0SIX2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T19573</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        <citation type="submission" date="2017-01" db="UniProtKB">
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                <consortium name="EnsemblFungi"/>
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            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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        <source>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
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            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SCB64064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="273" mass="29324" checksum="AADBF6B36C426F59" modified="2016-11-02" version="1">MLLVFLLNASFYSLRLTAYRVASTTMISSWQLAAVLLLAGPSLADNFTISNGQIFTPGFVVLDAPQPYTPLGGDTLHVAIDVTANGKLPLPSNDDDNDDDNQIFSIEMFLYSYVTGRNFTISNGTASANNASLGEIMAQEPGSTVKHVNWIWPECLVGDGAPEGDSDRGVYNISIRQNFRYNGDDYYTIFDVPISVNNSIPEGNDRPSCDGLSNEILSPEDIDVEAANEVGVLFAPGDATELDISGENSVGSVFGPSMRLYVGVVGVFMALLV</sequence>
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<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YHQ5</accession>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YHQ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00835"/>
    <dbReference type="eggNOG" id="ENOG502RY0X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YHQ5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="421" mass="46095" checksum="DF582BEEB3555F7F" modified="2016-11-02" version="1">MTPQNSIMPREAHVPPKPVPIGGDTMSVIVSLASVSVLSIFLYQRITAVRSWARLPFVAWLVLIIYVDSYGFVFTSAILTQVFGLNTSFNICHGAIILCLVCYVTTKILIYVFLVEKAHVIRSSTTRRRNSGLYLFNIITLLVGYGVVVVMNFVFRIARIVNGECFIGMEKISMIPLIAFDAVVNVYLTILFLIPLKNLYSFRNLPKTGANSRLRSVAMRTFVGACCTLTSSIVNLSVLMVLNGEPGWVCLMCCNSDVLFSAIVVQWVTSRDNAGSSSQVNSAALDNSYVGRQSSAAHQMSSMRASKAPNNSHDIDDEANLVSSGAVAFSSDNGSDVTKVSSGVVVTTTIHRQIKPTPGREGCLLDDDIETIGESDRDFPLRPAVYSPDKMDACEPTQTHIQGGRVQHQRTKTLSFSRPMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YHT7</accession>
    <name>A0A1C3YHT7_GIBZE</name>
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        <recommendedName>
            <fullName evidence="7">U three protein 23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FGRAMPH1_01T01133</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in rRNA-processing and ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UTP23/FCF1 family. UTP23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YHT7"/>
    <dbReference type="FunCoup" id="A0A1C3YHT7">
        <property type="interactions" value="1045"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YHT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01133"/>
    <dbReference type="eggNOG" id="KOG3164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YHT7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09865">
        <property type="entry name" value="PIN_ScUtp23p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000006">
        <property type="entry name" value="rRNA-processing protein UTP23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="160"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SCB64059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="286" mass="32968" checksum="E8DA34013360309D" modified="2016-11-02" version="1">MRGKRSKQYRKLMEQFSQTFGFREPYQVLVDAEMIQDSSRCKMDLEPALSRTVHGKVKSMVTQCEMRKLYATRNEDFIKLGQSLERRRCGHHPNEYPEPLSTQECLRSVVDPKDTNQNKHRYVVASQDQEVRRMLRGIKGVPLIYIKRSVMILEPMADESVQVRAREERSKFRAEIKSSVGKRKREDADDDDEKADKKDAGTTEDQKKKKKKGYGSKGPNPLAVQKPKKPKTDGQQPRKQESSEVKENTQEGAGKRKRRRRNKTSETEDQGEANTTTTTEVTMADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YHV3</accession>
    <name>A0A1C3YHV3_GIBZE</name>
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        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T02635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YHV3"/>
    <dbReference type="FunCoup" id="A0A1C3YHV3">
        <property type="interactions" value="401"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YHV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02635"/>
    <dbReference type="eggNOG" id="KOG2599">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YHV3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="7">
        <location>
            <begin position="120"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SCB64174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="352" mass="38866" checksum="86B81A4EA447C2D4" modified="2016-11-02" version="1">MSAIPTIPDTRVLAVASHVVSGYVGNKIAVFVLQSLGCDVAALNTVQFSNHTGYRQWKGTRVSAQEITDLWDGLKQSYLDDFDVMLSGYIPGAEAVDAVGKIGRELKDKSKDTPGKFFWALDPVMGDNGKIYVSPEVVPAYKRLIHDADLILPNQFEAELLSEVKINDMDSLRKAIQVLHDKYKVPHVVITSVNLEAPDHPPSHLSVVGSTMTSTGQARFFKIVFPSIDCYFSGTGDMFGALMVIRMREAVFNANEHLRHTTSWLSDDAVSAIELPLARAAEKVLGSMHEVLSKTCEGMKKVVERTTGDMKAEDRENDTKVHLVKSKAAELQLVRNLDCLRTPVTQYQAKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YI15</accession>
    <name>A0A1C3YI15_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T02493</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YI15"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02493"/>
    <dbReference type="eggNOG" id="ENOG502SHQF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YI15"/>
    <dbReference type="PHI-base" id="PHI:5833"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF55">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="32"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SCB64162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="365" mass="41081" checksum="BE18439CF9920CE8" modified="2016-11-02" version="1">MASEFTSTESNAMQVYAPSIVFFLVTPLFIAFRFWSRITRRTGLGWDDMTIIISFSCAVAVQTIMMVACNYGFGQHIKTLTPSDKIISLKLYYIAQIFYKLTMNLAKISMLLLYLRIFVHRWFRRCCFTLMGLVTCYMIASVTLSILQCYPISGAWDKSMPPTCIDLEKFWLANAGFSIATDSLILMLPMHPICTSKLSVTQKRGLIMLLATGGGLVITTSIVRTTTLSFTAKTPDTTFNISSTMWSIIEQNLAIICTCLPMCRLPIATRFPLWVSESELTARDVSEPADLSKRQTRRWSPYTGPRNVQGITRSIVITSDEMSDELTLDPVERTFTMSTLSSDIGAIRKIVEYEITFETASEAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YI27</accession>
    <name>A0A1C3YI27_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FGRAMPH1_01T03557</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
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        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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<entry dataset="TrEMBL" created="2016-11-02" modified="2024-01-24" version="17" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Sordariomycetes</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
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                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
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                <person name="Sakthikumar S."/>
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                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="RmlC-like_jellyroll"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SCB64630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="319" mass="35991" checksum="AD66592357A1DAF4" modified="2016-11-02" version="1">MRLFRLSDGVIEMPEKDSATRIIRSTDLKTASTAILHVIPNPGNETMRFYSHKNAYAAFIVWTGCFLFFDGDKTEQLRGGDFIFIPPGTVYGYQSLVSESELLVVTTLEDPAALLGALNEDQDEAECELPGPQHIDGYRPFDPAKPIDQDASLSTFLRPYSLNPYTCPRWIFGGVLARPFVRQTQCEGKFSISVMESSQVHRVRPFLNRWLNFTSVDHCFCVIEGTFLLKLKGQAEWTELREGQAMLISARQAFTADLGSEFLRMLVITNGIGIDELICRAGHEYESTTLPETADNRWDSWDEIRFRSACSEVGALLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLD1</accession>
    <name>A0A1C3YLD1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T24285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YLD1"/>
    <dbReference type="STRING" id="229533.A0A1C3YLD1"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24285"/>
    <dbReference type="eggNOG" id="ENOG502QVYJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YLD1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SCB65217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="527" mass="59031" checksum="4DB04295EC9DF9C4" modified="2016-11-02" version="1">MRNIKVPLEKRKRVSKACNTCMKRKQKCDGQKNCSYCRKKGMTCVYRPSKSTVSSSDSTVSCSPPNDLGEQSPEAVEYSDTPDISGKVTMRRSTSPGTLSSFRIASASRPGEFRKLTHPRTASDHQPITLCLPLPEPPFFSHCYATESFVALVKQHVERSSGSSDFTESSCLWSEPQQTSPASPCLIWPPDLPRITIERLVKSYFTNTLGFIDVTSPESVEAKLHRIYNGPSQVHYSDRCIIYLVLAIGLTFDSGLAEGALQVTNLKEQFFASAEALLQSIETQRGIETYNGVPWTLQALVLMSLYMLCVSRRHAAHSYCGRAFEVAQSFGIHRGKEAEGEGLSGTQAWIILRRKVWRSLFVLDRFLAATLGRPLTIHQHTEESLNMKKGTPLNFVVDACRIIDKTVKVIYSGSEISMKNVLSGIEYLDLLIDAQVDTAHSVEQVRVDPLCLYAEILLCRPFFLLRFIASTEEREALHNIEPQINKLSQRCVSKSMRVIETLKEGRCLTSSFPVDPFTPYVLIEATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLK2</accession>
    <name>A0A1C3YLK2_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation factor 1 alpha-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FGRAMPH1_01T27017</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the Dom34-Hbs1 complex, also named Pelota-HBS1L complex, composed of dom34 and hbs1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YLK2"/>
    <dbReference type="FunCoup" id="A0A1C3YLK2">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YLK2"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27017"/>
    <dbReference type="eggNOG" id="KOG0458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YLK2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Tr-type G" evidence="14">
        <location>
            <begin position="383"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="180"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SCB65431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="793" mass="86569" checksum="3696EF992407C42C" modified="2016-11-02" version="1">MSRHRIVHTFDTNDIVSEFDGDDYEEEGEDELSPEDRQAMDQGTAEVRAALGTEANKVTTTQIEEALWHYYYDVDKSVTYLIKTFIAPAPKPAKKTPEGMSVSFSASRRLLGTGADHGRLSSGYNFNMKLPPVDKVPACFFNDMPWLNIPQERQTHFIEPERPRGGLLGGGEGAPKMSKLQALAAARKKKTEEKKEQEKLEKGVSKLSVAGSEKENQSPFNQRQQIPTPASQAQPTQYDMDIDHEENEYKKPTPAHKDEFTLDSFPGVEIVTGPNPSALSRTLFGSAPANTQKPDVFAMPYTSSPSFLAQAFAEPSPDDIVFAAQAKAGKQPAPKAAKKPQKEKVKDASEAEKDVAGLKIVDAPPPKSKGLDVLKEYENSSNKRSISFVVVGHVDAGKSTLMGRLLLELKFVEKHTIDRYRKQAEKSGKQSFALAWVMDQRSEERERGVTIDIATNHFETEKTSFTILDAPGHRDFVPNMIAGASQADFAILVIDANTGAYEKGLKGQTREHVLLLRSLGVQRLVIAVNKLDMVGWSQERYDEIAQQVSGFLAGLGFVSKNIDFVPISGLNGDNLARRTEDPAASWYTGPTLIEALENSEPTTARALKSPFRMAISEVFRSQLGTTTIAGRVDAGSFQIGDALLVQPSGEEAYVKSIMVDSDMQDWAVAGQNVSVALTNIDPIHIRVGDMLCPTKNPINCSDNFVMKAMAFEHLMPMPVDLHRGRLHSAGQIVSIAATLDKVTGAVVKKKARVVQPGGVARVSVKLAAKVPLEAGQRVVIRSGGETVAAGLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLM3</accession>
    <name>A0A1C3YLM3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FGRAMPH1_01T27137</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YLM3"/>
    <dbReference type="FunCoup" id="A0A1C3YLM3">
        <property type="interactions" value="382"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YLM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27137"/>
    <dbReference type="eggNOG" id="KOG2111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YLM3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010314">
        <property type="term" value="F:phosphatidylinositol-5-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SCB65450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="381" mass="40613" checksum="56D54CBDB39FA9CD" modified="2016-11-02" version="1">MNVRPPIEASSSEAVLSVSFNNDASCFSVGLDSGICVFHTKSCLLKASRDFNAGIGLVQMMGTTNYLALVGGGRSPKFAMNKAIIWDDMKGKVALELTTLTAVRGVQLGRERIAVVLQNSVRVYSFTKHPDLLHIYETADNLAGLCCLSDKKLAFPGRTAGQIQLVELATGNVSIIPAHSSALKAIALSPDGELLASASEKGTLIRVYSTSNCAKLAELRRGIDPATIFSLAFSHCGTMLACTSDKSTLHVFDVPHPRKPGMNRSQQIGTPGADAGDGTGKWGILSKIPLMPRLFSDAYSFSSTHFEAGDEAAIGGIPFSESTVLGTSRPPKGVIGWIGDDSLVVIGAGHDARWEKFVIVDGEDGKRHCVREGWKRYLGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLN6</accession>
    <name>A0A1C3YLN6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T27057</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YLN6"/>
    <dbReference type="STRING" id="229533.A0A1C3YLN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27057"/>
    <dbReference type="eggNOG" id="KOG0256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YLN6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="80"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SCB65436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="456" mass="50492" checksum="720B0D2278DE9620" modified="2016-11-02" version="1">MLINLHFSVDKMSALSQRATEAVGGLDLPWRFAPRGDYDPDHNPTGLISFGTAENALVTDQLKEFADKSVTISNEDFLYRGSHAGGSRFPTALAAHLNEYLTPSSPITPDMIRCVGAATAMHDILAWGVADPGDGVLTSRPVYGRFELDFGNKSQAKVVYSDNKTEEAFQDGIIDHFEEALLRSSEAGIHVKMVLIVNPHNPLGRCYPKSTLVKIMQFCQKHRLHLLSDEIYACSVFNSDEPATPFTSILSIDSTNLIDPDLLHVTYGLSKDFGAAGLRLGAIITRSQPVLRAIEAAMRFHNPSGASLAIGNAMLEDRVWCRSFVDSSRSKLSQAHRHVTSQLKAMNIKYLPGSNAGFFVWIDLSPYLPSELDGELNQEFALAKRLREAGVFLHPREEHSLEPGWFRIVYTQDPRTVTEGLQSSQGQNGNIVGWTLEKRSTILAVNKVKEREGFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMD3</accession>
    <name>A0A1C3YMD3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FGRAMPH1_01T10919</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YMD3"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10919"/>
    <dbReference type="eggNOG" id="ENOG502QW0G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YMD3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SCB65671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="684" mass="76662" checksum="38F9A61520670B01" modified="2016-11-02" version="1">MSGEETILARRARLSQVPRACEACKVRKIRCDRSQPCGNCKAAGITCQQAHSTQQSDRPRQDNRISQLEEYVASLEARLAKVEVRLDKQPTQSTPASTDPPTSTPAVSKQDTSVSPAVSSEPSVYDVAQTPVGNLYEGSSSFISQFQQASEEIKQSAAAKTPEGQQSISESFNQLHSMLHDSSSRKPPPRGPTRSMPDITPLPASVVLKIIRTIKVNPTRFFPGHAMTDIKLIEHLCQKVYFPTEPVTLGHITSVNGIMRLLLREFIITEDPLSKEHDLEALKAQVERNFHLGLETFETVTVPSFENVIAITTAVLKIQNESRPVLARTLVNAGLSHCQMLGYHREITYQKDQSGFAEHKRRLFWTLYVCDKTNSLHLGNASRMQDFEVDAQYPSIPVDVAEKPWIELFHLVIRLAKIQGLIFDKLYSVAALQAPAIERRQWIDTLVADAHQWRYDLDRLDGSQVRFIKLLELSMVHWDIMYYTTLTTLLRAPAMPGVSTDMTSQCFQTARLALESHLRAFSGYDGVKLFTKADYIDWALHNSSFTPFVVIFLHSMAASSLDDVQLLEQVVDTFRHAREIHAGAERLYQICATFARLARRMVESRNTSVGMYDQNTDSLQVAGVSQDVPLIWPEAFVQPTGQGQQATSDSDVDAFLNDDMTSILADWINGQPPATEMFVMDFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMG7</accession>
    <name>A0A1C3YMG7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T10543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YMG7"/>
    <dbReference type="FunCoup" id="A0A1C3YMG7">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YMG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10543"/>
    <dbReference type="eggNOG" id="KOG2777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YMG7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043829">
        <property type="term" value="F:tRNA-specific adenosine-37 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042935">
        <property type="entry name" value="Tad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803:SF1">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A to I editase" evidence="1">
        <location>
            <begin position="53"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB65643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="368" mass="40343" checksum="B68A300245B93023" modified="2016-11-02" version="1">MTSQADLIAQAVLQQFHKLPAKRKPAIRDNGLHEWVPLSGIVAEQNGVLTCLALATGMKCLPVSKIPQSNGVGIHDWHAEILAIRTFNRFLIDECQSILEKEDKSSILQRKNHTSNSDGMCLQSFEIKDDVRLHMYCSEAPCGDASMELTMAAQEDASAWEAPTPTTRTPDPNADTSLLGRACFSRTGIVRRKPARGDAPPTLSKSCSDKLALKQCTSLLSALTSLFIDSTNAYIHSIVLPESQHSNVACRRAFSEEGRLRPLAEKMWAGGYSFKQFSVMTTGLEFEFSKIAVKNRADKISASNLAAAWSSSGFEENIIGGVIQGRKAFNTNAASRMSRRNMWEAARDLADRLGVGCSVTALYLKSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1R9L4</accession>
    <name>I1R9L4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG00161.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T00441</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315770.1">
        <property type="nucleotide sequence ID" value="XM_011317468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1R9L4"/>
    <dbReference type="EnsemblFungi" id="CEF72021">
        <property type="protein sequence ID" value="CEF72021"/>
        <property type="gene ID" value="FGRRES_00161"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00161"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00441"/>
    <dbReference type="eggNOG" id="KOG1287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013661_0_0_1"/>
    <dbReference type="InParanoid" id="I1R9L4"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000025">
        <property type="entry name" value="High-affinity methionine permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF353">
        <property type="entry name" value="METHIONINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="85"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="119"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="146"/>
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            <end position="203"/>
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            <end position="233"/>
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            <end position="415"/>
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            <end position="443"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF72021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="582" mass="63861" checksum="D64D2C8C2A17C9F7" modified="2012-06-13" version="1">MGFSFNQKSQATSQATSPGEVSESDSIIRDGELAFVRQTAGNGTSGYQEAVGAPVETRSPLGYNVNWITIIFLNLNHMVGTGIFSTPATILKLTGSIGLALVYWVIGFILAVAGLAVHMEFTSYFPNRSGSEVVWLEQGYPRPKHFFPVAFAVQSVLLSFSSSNAIVLSNYLWRIVGRAPDAWELKGVAIAAYTLAVITVLVHNRYSLWAINVFGALKLLLLLFIAISGLVILGGNFGSIPDPSLNFRNGFEGTTSSGYNLSQAMVNISFAFSGWQNAFSMANEIKNPIPTLKKNASASLLIVFVLYFLCNIAYFAAVPKDIFLESSELAAAVFFRTAFGKSAESALNFCVLLSSFGNLLAVLVSQSRQIREIARQGVLPWTEFWVSTKPFGTPVGPYLLKWAFTFLMIVAPPAGDAFQFVVSLKTYPDAIFFAAMGVGLLLIRRRRSRSNTPPSDFRAWHALVILYILSQIYLLVMPWIPPVGGIYGGTVSFLWCTYMIVGIAILGVCGLYYYVWMKLLPRWGGYKIRSQVISVDDNGANTHRLLKVPNDEVAEWDATHDDLGRDLPAGQRVTTEISNISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RA47</accession>
    <accession>A0A098D066</accession>
    <name>I1RA47_GIBZE</name>
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        <submittedName>
            <fullName evidence="8">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG00371.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T00981</name>
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    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316033.1">
        <property type="nucleotide sequence ID" value="XM_011317731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RA47"/>
    <dbReference type="FunCoup" id="I1RA47">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RA47"/>
    <dbReference type="EnsemblFungi" id="CEF72293">
        <property type="protein sequence ID" value="CEF72293"/>
        <property type="gene ID" value="FGRRES_00371"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00371"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00981"/>
    <dbReference type="eggNOG" id="ENOG502QPTQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_10_0_1"/>
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    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CorA soluble domain-like"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="810"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="467"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF72293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="836" mass="94503" checksum="F4848CE995E15B3C" modified="2012-06-13" version="1">MSSNRYTDLANPSRSAAAPPASDPNQSQAPESSNNSNASRAARKRKGHRGGRKKRTRRKSFAAMDDDDDHDETREAAGEGFFNLPRANLSNTSIDSEALLDHRDHQPLRPRRTSTVPLPGGMSVSSPFSSSAGNRLRSIPAVSAEEEHQDHTQWDENAPLLGESIISGYGASDARSNRTRSRRPSNKSSTTRLGTSSGARDNNYDVNAPPSMPGSPTFGTADRIELSLGDVMIRDGLGGRDDSPHRLMGEMDCLSDMDNMRDGRPDIGRRMATEAEQDVCFPVPGMSEIGDDDAQSQAHEHRQYRTRRRRGQWPDLSVLEEWSSMEKEDRTEERRVKRITEPQLINGRLRPIRKGQFYEAIEESPYRFTYFNEEFQSTVHSQTISELVQPGGGFRELFVPDPRVLSDDESDDEDVEPILPTKLHNLSTEGNSKVHTRQPSLSTVHDNYEQREGTISPLKDPLAHVVSRSESGNATPTGRKSADETAHVSQNTEGGSNEKMIRYGERPVWWLDVLCPTEAEMKVISKAFGIHPLTAEDIMLQEAREKVELFRHYYFVNYRSFDQDEDTNNFLEPVDMYVVVFREGVISFHFSRTPHPANVRRRIRQLKDYLILSSDWISYAIIDDITDVFAPLIEKIETEVDDIDDAILRLHSSADKRLNEESSKNDDAMAASDSNIDMLQQVGECRKKVMKLYRLLGNKADVIKGFAKRCNERWEVAPRSEIGLYLGDIQDHIVTMTANLGHYEKILARSHGNYLAQINIRMNERQEQTADVLGKLTVLGTIVLPMNIITGLWGMNVWVPGQEYEGDLQWFFWITAGLLFFGFACFMIAKRVYNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1RA59</accession>
    <accession>A0A098D1I1</accession>
    <name>I1RA59_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG00383.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T01005</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CENP-H/MCM16 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316045.1">
        <property type="nucleotide sequence ID" value="XM_011317743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RA59"/>
    <dbReference type="STRING" id="229533.I1RA59"/>
    <dbReference type="EnsemblFungi" id="CEF72305">
        <property type="protein sequence ID" value="CEF72305"/>
        <property type="gene ID" value="FGRRES_00383"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00383"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01005"/>
    <dbReference type="eggNOG" id="ENOG502S9QV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078299_0_0_1"/>
    <dbReference type="InParanoid" id="I1RA59"/>
    <dbReference type="OrthoDB" id="2274804at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043515">
        <property type="term" value="F:kinetochore binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040034">
        <property type="entry name" value="CENP-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008426">
        <property type="entry name" value="CENP-H_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48122">
        <property type="entry name" value="CENTROMERE PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48122:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05837">
        <property type="entry name" value="CENP-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere protein H C-terminal" evidence="9">
        <location>
            <begin position="26"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF72305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="233" mass="26171" checksum="461889B905D3D91B" modified="2012-06-13" version="1">MEDKGDTLMVNGDIETSHLPMSEDEEKILALYDRIQELQLEIAIINAQQSHQSDDTALFTDEETQNAQSDLLETRAQYVLRNDVTEAVVTANPILKAVHSNAETAPIERELLPFIERRDEASVSVARQASQTNEVWKALTTAQSDTLRKSRENVTLAAELFELADQAKLKKRVPPNNSKMMEEQKRLEAEVKASKQKWRVMKGVAGGIIVGSGVDWVQDDELRDVVLDPETDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1RAC2</accession>
    <accession>A0A098D0F1</accession>
    <name>I1RAC2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG00449.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T01163</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316118.1">
        <property type="nucleotide sequence ID" value="XM_011317816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RAC2"/>
    <dbReference type="FunCoup" id="I1RAC2">
        <property type="interactions" value="1432"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RAC2"/>
    <dbReference type="EnsemblFungi" id="CEF72383">
        <property type="protein sequence ID" value="CEF72383"/>
        <property type="gene ID" value="FGRRES_00449"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00449"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01163"/>
    <dbReference type="eggNOG" id="KOG0270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023867_0_1_1"/>
    <dbReference type="InParanoid" id="I1RAC2"/>
    <dbReference type="OrthoDB" id="270624at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000457">
        <property type="entry name" value="rRNA processing protein Pwp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001345">
        <property type="entry name" value="WD40 repeat-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="272"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="408"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="501"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF72383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="541" mass="60395" checksum="85B2F57BFA8B7102" modified="2012-06-13" version="1">MSSMITAAQWVPRGFAAPFPQKYTLDEAEFERIAELAKLQLDDAQEDLEEAEEAANTGVKADKTEDKEDDSEMKIDDDEKPTDKNEINLNDDDLKEYDLENYDNDDDEDAPGQGEGMGMFGNIKSLAYYESNKDDPYITIDADKEQEDEDREELQVLATDNLIVSAKVEDEMAHLEVYVYEDEADNLYVHHDIMLPAIPLCVEWIDMPVNKAGVEKDAAGNFVAVGTMDPDIEVWDLDTIDCMYPNAILGQGGNEEEKKMKKKKKKSKKSNDEYHVDAVLSLAANRKHRNLLASASADKTVKLWDLNTTKCAKSYTYHTDKVCSLAWHANEPTVLLSGSYDRTVVAADMRAPDAKAPRWGVESDVENVRWDPHDPNFFFVSTENGVIHYHDVRNAPSDPTGTKAVWTLQAHDESVSSFDINSVVPGYMVTGSTDKTVKLWNIQPTGPSVVVSRNLDVGKVFSTTFAPDPEVAFRLAVAGSKGTMHIWDTSTNASVRKAFATRVPEQRGKGEDRLVGVNNDDSSDDEDDEDDNEDDDSMEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>I1RAG5</accession>
    <name>I1RAG5_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="7">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="7">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG00493.1</name>
        <name evidence="7" type="synonym">MDE1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T01263</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="7"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316167.1">
        <property type="nucleotide sequence ID" value="XM_011317865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RAG5"/>
    <dbReference type="FunCoup" id="I1RAG5">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RAG5"/>
    <dbReference type="EnsemblFungi" id="CEF72433">
        <property type="protein sequence ID" value="CEF72433"/>
        <property type="gene ID" value="FGRRES_00493"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00493"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01263"/>
    <dbReference type="eggNOG" id="KOG2631">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_4_0_1"/>
    <dbReference type="InParanoid" id="I1RAG5"/>
    <dbReference type="OrthoDB" id="191080at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000003">
        <property type="entry name" value="Methylthioribulose-1-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF72433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="256" mass="28778" checksum="E3B3FE4E63225C9D" modified="2012-06-13" version="1">MAAEQQRLTGDALITSEDPNHPANLIPSLCAKFWTLGWVTGTGGGCSIRDDDLVYIAPSGVQKELMKNTDIYVMALSEQDPNHNKLNQRTYLRSPPCYKPSQCTPLFLAAFTRRGAGCCIHTHSQWAVLVTLLLESQGPGKDRVFEINNIEQIKGFGRGMNKTGNLGYHDTLRIPVIENTPHEEDLTEYLEEAMDKYPDAYAVLVRRHGVYVWGDNVHKAKTQCESLDYLFQLAVEMKKLGLPWISEVEQIAPQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RB50</accession>
    <name>I1RB50_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="9">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG00757.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T01907</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316467.1">
        <property type="nucleotide sequence ID" value="XM_011318165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RB50"/>
    <dbReference type="FunCoup" id="I1RB50">
        <property type="interactions" value="809"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RB50"/>
    <dbReference type="EnsemblFungi" id="CEF72755">
        <property type="protein sequence ID" value="CEF72755"/>
        <property type="gene ID" value="FGRRES_00757"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00757"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01907"/>
    <dbReference type="eggNOG" id="KOG1780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_10_1_1"/>
    <dbReference type="InParanoid" id="I1RB50"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036261">
        <property type="term" value="P:7-methylguanosine cap hypermethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000019">
        <property type="entry name" value="Small nuclear ribonucleoprotein G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF72755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="84" mass="9470" checksum="0EFAFA545AA2C80B" modified="2012-06-13" version="1">MAPAQPELKKYLDKRLFVQLNGSRKVIGVLRGYDVFLNIVLDEAVEEKDNGEKVRIGMVVIRGNSVVMLEALERIGGDDRRGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1RC16</accession>
    <name>I1RC16_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG01117.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T02785</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316884.1">
        <property type="nucleotide sequence ID" value="XM_011318582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RC16"/>
    <dbReference type="STRING" id="229533.I1RC16"/>
    <dbReference type="EnsemblFungi" id="CEF73194">
        <property type="protein sequence ID" value="CEF73194"/>
        <property type="gene ID" value="FGRRES_01117"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01117"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02785"/>
    <dbReference type="eggNOG" id="ENOG502SF7P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048904_2_0_1"/>
    <dbReference type="InParanoid" id="I1RC16"/>
    <dbReference type="OrthoDB" id="21513at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051870">
        <property type="entry name" value="Elongin-A_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010684">
        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141:SF76">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF73194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="379" mass="41647" checksum="CD5E41BB10E01587" modified="2012-06-13" version="1">MPVKSLAELAIAACIKNIRSVDSVGDFLLYKTVRTLLLKIDNPKLLRKIEINSPQIQGETGEVWLKLIKQHFPMELKQKAFKPPDPTQWYRVYDKYKAAHQKALDESEAKLRNDLLGLQQAKHKTTIIEDRRLLPQGGRVGTKKPWGAPRDSNGSTLAFTRGSRTKTNNGASVMRKVRRETKEIASIHGKLSRPTQASNAITKLRKAPIAMVNDYQRASQPAIRAPSKPTPSDVVAAHEERAQYISDLDSDDDNGGGDDLFDDDPSPPRKVASRPSSSAPRRPAPGPSKPATNVKRSGLLSNSYKGPQPKAATTPSQPRASRPVKQEKRSLSPEQTVLSSSPEPGPSSSPPAPVARPFSAVNPRKRKGTGIFHKPKRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1RCX4</accession>
    <name>I1RCX4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG01458.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T03583</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317264.1">
        <property type="nucleotide sequence ID" value="XM_011318962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RCX4"/>
    <dbReference type="STRING" id="229533.I1RCX4"/>
    <dbReference type="EnsemblFungi" id="CEF73597">
        <property type="protein sequence ID" value="CEF73597"/>
        <property type="gene ID" value="FGRRES_01458"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01458"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03583"/>
    <dbReference type="eggNOG" id="ENOG502REQX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_678014_0_0_1"/>
    <dbReference type="InParanoid" id="I1RCX4"/>
    <dbReference type="OrthoDB" id="4819569at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF73597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="406" mass="45387" checksum="3377C1E31EE1FF4F" modified="2012-06-13" version="1">MYSPQYRKGGIRETTCAATGTICRNTTTNLRIDGHTFKSLYCQFHACRQIEAGRACAVAKPPSAIVCSQHSRCQAVDNGMGCALDVKDGNTAMHKYCIQLHLCGFSGCENERSKRNEQYIPFCVDHRCEQDNCRNSKDVGIFCRSHTCDDQYCVAFAPGIDLDDPQRFCKRHRQCQKPQCPRLCHTRDDGQPSPFCGAHYCQAPDCEDGREAGLFCPEHTCAELGCLKGRESFKTEYCKSHKCKTKHCRLRRLDSGYCPYHEVDFAKSTDGAWSRALEEGFQLKGWDTLCMEMASMTEEDVAEELNMAISSVNTICVRSTIARLQGLDHPTSVSITGALQWDAMNPGRYNPKSGFEATPMGCSAKSMLVAMLVVKTKMLKIQTDARGTEEATCQDLDQGWNQKMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1RDH0</accession>
    <name>I1RDH0_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair protein RAD14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG01666.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T04055</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317491.1">
        <property type="nucleotide sequence ID" value="XM_011319189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RDH0"/>
    <dbReference type="SMR" id="I1RDH0"/>
    <dbReference type="FunCoup" id="I1RDH0">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RDH0"/>
    <dbReference type="EnsemblFungi" id="CEF73835">
        <property type="protein sequence ID" value="CEF73835"/>
        <property type="gene ID" value="FGRRES_01666"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01666"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04055"/>
    <dbReference type="eggNOG" id="KOG4017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053731_0_1_1"/>
    <dbReference type="InParanoid" id="I1RDH0"/>
    <dbReference type="OrthoDB" id="5368863at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21077">
        <property type="entry name" value="DBD_Rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.530.10:FF:000003">
        <property type="entry name" value="Dna repair rad14 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022658">
        <property type="entry name" value="XPA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00753">
        <property type="entry name" value="XPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="12">
        <location>
            <begin position="224"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF73835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="379" mass="43372" checksum="78B22389747E3332" modified="2012-06-13" version="1">MERPSTPPRATKPAPVISPPTPEVTKRIEENRLRAKAIRDQREAEQRATGTVPEIPKSSGGFVPTDDVYISKTANGKRPYSSISTTEPKGTNRDGRNKGDEETLRPARKFTKFVDYNMSAMTDTKGGFLSTEDDPHNYALSGKKQDDAQQRPKHMSVQEWERLQLIRNLKRLKAGPYEPGLSVLADDETRKKCRDCKSLEIDFVWEEVFHLCVCNKCKEKYPEKYSLLTKTECKEDYLLTDPELRDPELLPHLSKPNPHKSHWHDMMLFLRCQVEEYAIKTKWGSAEALDAEYEKRETQKKARKEAKFKEKLLDLKKKTRTDAFRRQAGNLSKSGASKFGDAIGGGKHVHEWGRTVENEDGMTVKTCVDCGMEVEEMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1RDW0</accession>
    <name>I1RDW0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG01828.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T04423</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317670.1">
        <property type="nucleotide sequence ID" value="XM_011319368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RDW0"/>
    <dbReference type="STRING" id="229533.I1RDW0"/>
    <dbReference type="EnsemblFungi" id="CEF74018">
        <property type="protein sequence ID" value="CEF74018"/>
        <property type="gene ID" value="FGRRES_01828"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01828"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04423"/>
    <dbReference type="eggNOG" id="ENOG502SHCN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040908_3_2_1"/>
    <dbReference type="InParanoid" id="I1RDW0"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124072" evidence="1">
        <location>
            <begin position="19"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="2">
        <location>
            <begin position="26"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF74018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="312" mass="34915" checksum="CED26CCE51424833" modified="2012-06-13" version="1">MRQSLFYHFLYLWGAVEGVDLSSKRGLAFHGDDHEADNKLLTSNNSEIAWYYTWSLWPAQQIGNSLPFVPLIHGLDDASDSELQNRLNNLPDSSTHLLTFNEPDGETDTGGSAISPKDAAKAYMKNIVPLRDTKREWSISHPSVTGSPRGLEWLRDFNESCYDIDDKGCPTDFIAVHWYGDAVGLDNWLNSLRDFYNETAPDAPFWITEMALPKEDEEATLAMMNETLPNLDKRKDVEAYAWFGAFRKNDANEWTGKNVALFNSDGGLTKLGAEYLGGEDKGFEEGTSEGIVRMPSMGLLGATMFAAAVYLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1REE7</accession>
    <accession>A0A098D5P1</accession>
    <name>I1REE7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG02035.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T04915</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317908.1">
        <property type="nucleotide sequence ID" value="XM_011319606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1REE7"/>
    <dbReference type="EnsemblFungi" id="CEF74264">
        <property type="protein sequence ID" value="CEF74264"/>
        <property type="gene ID" value="FGRRES_02035"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02035"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04915"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_285454_0_0_1"/>
    <dbReference type="InParanoid" id="I1REE7"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="186"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="943"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF74264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1096" mass="124443" checksum="4FD888D41E8FC701" modified="2012-06-13" version="1">MAEIVNVKDAASRLAQFADEAVSFFQQLNSSNKDIIKRLEQWESLSRLANEVESVPSTDSNDTEKQLEFTTQILLHCSEITKDILTGFDWREFTLDDPGLVTVYDRLNGKRVKTLFEDLEREQLCLVAFRESEFKTLSCVPKFTNQPEYSDSFKEREKELLHYLFVTDPRQDLASLESAKGHVTEGTCAWITEIPDFRYWLLPPSKCKGLIIQGSQGTGKTMLSSYIAGQLERLSGHTPDETVLYFFCNQGNIYKNSATAVLRGLIWQLCKLRPQLIHHGLGKIRAHGSDRIALAKNMVEILWQIFIAMLRDPAAGAITCILDGIDECDVSSIRGLTDRFSELLTSPKSPQNFRLLMTCLSAPVQIKHKDTFSILSLDSELQENNACDVQLYINTSLKEIAQDNEWPLQLHSKVETALASRPNQSFHWASLVLSDLRYKSQLQIPLHIRCLSNSFETIYGNILQEISVEHRKRVRLLFSWLLLAYHPLTIEELNALIGDQNSDSETSIEDLKACIRVCRSLVVIRPETKKLGLEYETMQTIQLSQRSVRDFLHRYMTAERAGPGAFQIHTDKDHESISSRCLDLMEELLPIWSEDNTDERSDLVLPYATRFWFRHLGECPQLLQDDKIAAKAMSFLTQDHVSRGLWFTYLSKFKDTREYIKRQWTARKHGHHFPTVNGLGEITNVIMVEQPKDLISAERLSALQLASLLGMIPIVRKIIDTTNLARYLRQTNIRSSLYSVYFTHPRSRTRISETQEGQPILATAELVAMTPLELAVFEGHREVVSLLLDSHPHSSMRPDSNFALETAISQCDREMVKLLMGAGASKLKASKNFDGPIGTAMANNRLDVVRFLCNSDNNIWEREDSKRDEITYALLHLANDATPYPHDEPRFEEYARVLLQGNASPNGTVSCREGHSLRHLKYGVLQLLHSRGITLQALGPFPDEQTPLMLAISSMHLSCDGVDPTEIVQFLLDSGASVNQTDRKGWSALHHVANQIALGRAKKAWEDMHDGEEYRLYAIAGLLIEAGINQDLEDREKRKAADILEIVGAPVWKRDNSCFYFWPSSSALKENTIDDKKKTHKVDLAALMSICISYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>I1REX4</accession>
    <name>I1REX4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG02233.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T05381</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318128.1">
        <property type="nucleotide sequence ID" value="XM_011319826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1REX4"/>
    <dbReference type="FunCoup" id="I1REX4">
        <property type="interactions" value="1275"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1REX4"/>
    <dbReference type="EnsemblFungi" id="CEF74495">
        <property type="protein sequence ID" value="CEF74495"/>
        <property type="gene ID" value="FGRRES_02233"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02233"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05381"/>
    <dbReference type="eggNOG" id="KOG2171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003794_1_1_1"/>
    <dbReference type="InParanoid" id="I1REX4"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="26"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="10">
        <location>
            <begin position="335"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="386"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF74495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1101" mass="120894" checksum="132783E83B9BF7B5" modified="2012-06-13" version="1">MDKGKLAQLLEGSQVPNTEQVKAVTAELQKNFYTKPESLLALVEISLTHGDAGVRQLASVQALRLIPKFWEKTAQDQRQLARNHLLEGVLKESSAGVRHSLARLIAGIVSADMENGEGEDFLKHILPLSNNDNVIAREVGSFLLYAILEEDPTHFADNTHDLLKLFQSRIEDPQSKEVRINIVRAIGAILMIIEPEEDEVALKAMQGFVPSLVNILKATVEAEDEESYKIVFEVFHSFIAYDSSLLALHLRDLLSFMIELGGNVNAEEDARSQALAFLIQCVRYRRMKIQGMKDMAAELMVKAMHIVTELDPDDDEEDLSPARTAISLIDTLSNELPPRQAIVPLLEQFPHFAGNNDPKYRMASMLALGNAAEGAPDFISTQLQPLLPAIISLLEDADTRVRHASLVGLIHLAEEMADEMSSHHEQIISSVLKNLEAASQGPSDKSNVSIIRCACGALDTFGDGIDTKIMAQYGPNLIGPMVRLLDHEDFGVKAAAASAIGAIASSMEKSFEPYFKDVMTSLGKFVSIKEGEESLDLRSSTCDSLGRIAMAVGSEAFQPYVMDLMTASEEALSLDNPRLKETSFILWSNLSKVYHEQFDHFLPGVFKGLFSSLELEEEEIEIPGIDASQLGDGSIVVGGKRVKVKAPENEDDATIANGGDEDWDDIEDMDDLDDLGAVTAVALEQEIALDVLGDVISNSCNSANLETYVEQTIEKVSPFTEHTYEGCRKTAVSTLWRTYARVFQVWEEGSGVKWEAGLPAKHTPPASLISMAQALEKATMTIWSDDSERTVITDINRNIAATLKACGPAVLTCKDGFLQELVSVVGLIITRSHPCQQDLGDEEEEPEVDAGSSEYDWLVIDTALDVVVGLAAALGPSFGELWKIFEKPILRLASSSEDLHRSTAVGTIAEITKYVGEAITPFTESLGQALVRRLTDPDPLAKSNAAYAIGLVVLNSSDTSKTFPMYPHLWEKLEPLLTVNEMRMTDNVAGAVSRMMAKNPNNEFVAQALPAVANVLPLQEDYEENAPIFENIYNLYQHSNPTVEQLTPQLVGIFEKVLSPPEEQLEPETRQILQQTVQMLYKAKPDLLANNPGLLKLANIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I1RFQ2</accession>
    <name>I1RFQ2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG02537.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T06091</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318474.1">
        <property type="nucleotide sequence ID" value="XM_011320172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RFQ2"/>
    <dbReference type="EnsemblFungi" id="CEF74850">
        <property type="protein sequence ID" value="CEF74850"/>
        <property type="gene ID" value="FGRRES_02537"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02537"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06091"/>
    <dbReference type="HOGENOM" id="CLU_2133726_0_0_1"/>
    <dbReference type="InParanoid" id="I1RFQ2"/>
    <dbReference type="OrthoDB" id="10273072at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF74850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="113" mass="12534" checksum="897E931933B73331" modified="2012-06-13" version="1">MANARFFAAFAGQEEPLFGESACRNREKPVMLGERARRVVGAGPDLINERKQTRGSWLGRSQVCEHGANKRENPLEPIIWIYQKGSVWSCGNRMCIHVKNGGRDEACGDSLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I1RG38</accession>
    <name>I1RG38_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG02687.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T06437</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318638.1">
        <property type="nucleotide sequence ID" value="XM_011320336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RG38"/>
    <dbReference type="EnsemblFungi" id="CEF75023">
        <property type="protein sequence ID" value="CEF75023"/>
        <property type="gene ID" value="FGRRES_02687"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02687"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06437"/>
    <dbReference type="eggNOG" id="ENOG502R9JA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018494_0_0_1"/>
    <dbReference type="InParanoid" id="I1RG38"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052176">
        <property type="entry name" value="Glycosyl_Hydrlase_43_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124131" evidence="7">
        <location>
            <begin position="20"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF75023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="585" mass="66091" checksum="F091A58B11EBE15B" modified="2012-06-13" version="1">MQFPSIVTGLMCLCASSLASKHDSKTPQFHNSANHLGADPHVIYDSKTGQYFAYSTEGADPGSLFAIYSSPDLSTWHKHPGGVLKACYDDDMNRIKGGQACWARDWYWAPETYYNEKTDWYFFFFAGRLREDLAKDYFRYSDFEEPSKIGVAVSKSPTGPFREIKSKPIDYYPFDPDYYDVNLIMDEKQMRPPQTLKEGKTAPKGTYIPTIDVNIFFDKDGKVYLYLSRNAYRNWNWDKKLGKYIEESNIIVVEMERDWWDDPKAMTMPEIIASQKDIHAKDAPKLPQNITSYNGTGEIGSPPRKDGWKTVISYGADPQDWENYHVNDYEKNNGTKKDRRWAEGSTLIRRPGKNGKPVYLLTYSANNYEASNYGVGFATSKSPFGPFRKSANNPILSQKPDAKIPIYSTGHGSIVASPAKHNKKVGAQDVILQTPPGSELFYVHHARNSTERDRSIYTTRMTIDDSAMYFGSNDAMSMDLSSLDQPLPKNTYPIHMDARCSKKKGVCQFHVKVVSKPGASFDILEGTNRVIALPGNKVATSIKSDMRAGYFVMSFGSASVKELAYQRLSVDGSWSTITKKKVTCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1RGF3</accession>
    <name>I1RGF3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG02813.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T11373</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322999.1">
        <property type="nucleotide sequence ID" value="XM_011324697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RGF3"/>
    <dbReference type="STRING" id="229533.I1RGF3"/>
    <dbReference type="EnsemblFungi" id="CEF77489">
        <property type="protein sequence ID" value="CEF77489"/>
        <property type="gene ID" value="FGRRES_02813"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02813"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11373"/>
    <dbReference type="HOGENOM" id="CLU_1722468_0_0_1"/>
    <dbReference type="InParanoid" id="I1RGF3"/>
    <dbReference type="OrthoDB" id="5067689at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="167" mass="18742" checksum="8929AB5848CE1A14" modified="2012-06-13" version="1">MSHAKDTTTPDPKGKGKEVADPAPKSILKSTQDASANISQHVNFSWEANTITRIPADNRGRRLPTGKENRRERLYYNLEKNRVVANNSSVECGAYVTQDDTWDEWEMISRPGQEDATSEVGGEITSCREVMNLPGDDRAASILSEPFENTCTRLQRQLQRDSETDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I1RGL2</accession>
    <accession>A0A098DF18</accession>
    <name>I1RGL2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG02883.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T11531</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322922.1">
        <property type="nucleotide sequence ID" value="XM_011324620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RGL2"/>
    <dbReference type="EnsemblFungi" id="CEF77569">
        <property type="protein sequence ID" value="CEF77569"/>
        <property type="gene ID" value="FGRRES_02883"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02883"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11531"/>
    <dbReference type="eggNOG" id="ENOG502RCH9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023111_1_0_1"/>
    <dbReference type="InParanoid" id="I1RGL2"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="PHI-base" id="PHI:5711"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF142">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124132" evidence="3">
        <location>
            <begin position="22"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF77569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="476" mass="51996" checksum="8B210C2585E83168" modified="2012-06-13" version="1">MLVSTKSFLLTAALAPIVVLGETVLGITVFSRHGDRTSKHYKGYTLTNLGFQQNYQVGAYYRSTYLDSGASKQILGISEDQYVPNEIWTSAPDQMVLLNTATAFLQGLYPPIGNNQNVGVQELNNGTGYTAPLNGYQYVVLHGEDENSPDTIWIKGDESCPAATKDQKSYSQSTQFKDTFAATRQFYGDLYPLMKDVYDYKPENMTYQNAYDIFDLINVASIHNKSFSVEPEKLDQLRLLADRSEFGQNYNASAPDNRSIGGKTLASAILNQLNQTVTGKGKLKFSLLAGSYDTFLSFFGLSGLTKANIDFYGLPLYASTMAFEIFTENNVTSFPSSTDDLQVRFLFRNGSDDGTSLSQFPLFGQAREGMSWTIFVKEMQKRSITTVSSWCTMCGSTEEFCVAALRGDSASPTSPDSSSGSGISNAVAGIIGALVTLGVIAICSLTIFLIRHKKAHKAATTEEAGYTSSISNKNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1RI89</accession>
    <name>I1RI89_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG03518.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T13073</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322191.1">
        <property type="nucleotide sequence ID" value="XM_011323889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RI89"/>
    <dbReference type="EnsemblFungi" id="CEF78340">
        <property type="protein sequence ID" value="CEF78340"/>
        <property type="gene ID" value="FGRRES_03518"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03518"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13073"/>
    <dbReference type="eggNOG" id="ENOG502RV0S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019025_0_0_1"/>
    <dbReference type="InParanoid" id="I1RI89"/>
    <dbReference type="OrthoDB" id="5102830at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124248" evidence="2">
        <location>
            <begin position="20"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF78340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="714" mass="72226" checksum="0E3D9EFE626FCC72" modified="2012-06-13" version="1">MHFSNLLPTLGGLVAVAQASPHLLPGVGLGLGVDVSLGGKGAGIEAGVSLGSTKETVADLPKKVTADPLNATKQSSANGVSTCPLAHSWEDHTLFQGVAAPASASGAAIKLGINLPKAQIQGDATLELVKGFLQEPRVRIGLGGVKAYVEVDVSASAAVQESIELFASPALEIEVPGLLEAEAGAAIALDLVVGVDAAIDLSAGVYLAFGEEAFVEVSLLTKDIVDVSLEGLVAKALPIGVAAEVDLSAAVNLQLGLRLRTEIDLEAELDIPVLDIEAGAKVAIWVSLFEYTAALVATDNCVVSVDEVIALTLGLAVDLNVEIGDILELNLAPTLTVELATAAKAKVCMPNRGSTGSFIEQAGQDGDKSHTRVISLATVPAGSEATPQGYATPNASGNSADPKATGGNPLYGSAAKPVTTAPAVIATPAHGNGTYGDVTRTIKSTKVYTITSCAASVINCPARYTQKVVTSTIIESTYVCPATETGAVPAMTTSAHTAPVPVTTITDTLTTIVPCKTRTTKTFQPPTNSPPAPTVTIVESTTYCPETGKSTQTGGSELPHVTTGVPSKEVPNPPAPTTEANEKPTHSAPTPEKPTGDKPVLPPVATVPYPPHGNGTVPTPTPVVPVVPSSYVPPVVSTPVAQPPHSVVPPPVYAPPSEIPPVASHPVSQPPAVVPPPAAGTPPATAPTPVPVSGGSVVRTGLMLAVPAVIAVFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJ66</accession>
    <name>I1RJ66_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG03871.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T13921</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321802.1">
        <property type="nucleotide sequence ID" value="XM_011323500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJ66"/>
    <dbReference type="EnsemblFungi" id="CEF78763">
        <property type="protein sequence ID" value="CEF78763"/>
        <property type="gene ID" value="FGRRES_03871"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03871"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13921"/>
    <dbReference type="eggNOG" id="ENOG502SNXC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120086_0_0_1"/>
    <dbReference type="InParanoid" id="I1RJ66"/>
    <dbReference type="OrthoDB" id="3758478at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF78763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="150" mass="16468" checksum="A86C452A249D81BC" modified="2012-06-13" version="1">MSSTKELRIAIEHTTRQFLGAYKDCGEANDPSIINRDVTEDCERHFLPTGVMALVGAPTVVKLNNAAYEAAVAQDMTKSVVTGTRISNLVIDTEACKAAATTVTDVKFHDGEVVAMEHSWVLEFNDDGSKVRKVVEFCDMNGVRRMVEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJA5</accession>
    <name>I1RJA5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG03914.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T14021</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321754.1">
        <property type="nucleotide sequence ID" value="XM_011323452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJA5"/>
    <dbReference type="EnsemblFungi" id="CEF78813">
        <property type="protein sequence ID" value="CEF78813"/>
        <property type="gene ID" value="FGRRES_03914"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03914"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14021"/>
    <dbReference type="eggNOG" id="ENOG502QSGT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066901_1_1_1"/>
    <dbReference type="InParanoid" id="I1RJA5"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053152">
        <property type="entry name" value="Hydrolase_YcaC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559:SF3">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124245" evidence="2">
        <location>
            <begin position="19"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="34"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF78813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="243" mass="26911" checksum="D4284BD2FE4EF7E1" modified="2012-06-13" version="1">MKFTSIFTAGLLSASALAKQAAYKYERLDKDDALLLVVDIQEGLYQLTRDWDPTLYHHQSMAHAAIGKAFDMPVILTTSADQGPNGPLMREIRQMYPKAPLVQRQGQVNAWDSEEFQQAVKATNKSQIILAGITTDVCTTFLALSLRDAGYSVWANIEASGTTTPLIRDVSNDRMRDAGVQVVSLFSIICELMRDWRNTPGSKEIYPWLGQYFPIAGYMARGHAAAIANGTIQPGEEGYLNYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJC5</accession>
    <accession>A0A098DIP0</accession>
    <name>I1RJC5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG03936.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T14071</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321731.1">
        <property type="nucleotide sequence ID" value="XM_011323429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJC5"/>
    <dbReference type="STRING" id="229533.I1RJC5"/>
    <dbReference type="EnsemblFungi" id="CEF78838">
        <property type="protein sequence ID" value="CEF78838"/>
        <property type="gene ID" value="FGRRES_03936"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03936"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14071"/>
    <dbReference type="eggNOG" id="KOG2451">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_5_1_1"/>
    <dbReference type="InParanoid" id="I1RJC5"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000023">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF7">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="32"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF78838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="500" mass="54041" checksum="49BAFCE6AFF20E25" modified="2012-06-13" version="1">MAHELPFKLSRPDLLITDSYIAGQTTSALSGATFDVLDPGTNKPWAKVKDNSADDVDHTVQVAYDAFQTFKKTSPRLRAQWLLKWDALIREHKADLATLLVYETGKPYAEAIGEMDYSLTFTSWFAGEAERIQGTCFMPSAPNRRVFTIKQPLGVAVALVPWNFPVAMVLRKAAAALAAGCTMVVKPSPETPVTAMALAKLASEAGFPNGVLNILPTSLDNTPSLSEALCKHDLVKKVTFTGSTRVGTLVANLCSLGLKKVVLELGGNCPCLIFNDADIEAALRELVGLKWRHAGQACVTVNRFLVQSAVYDKFLQRFAEETAKYVVGHGASEGTTLGPVTKPESLDRAERLIKDAVSKGARIVTGGNRLSPKDGEGGYFFEPTILADMTHDTLISCEECFAPIAAFYKFETEEEAVRVANDTPMGLASYAFTKDADRIWRLFENLEAGMIALNTGNSSAAESPFGGIKMSGYGKEAGKDVAVNEYMIQKTGTITVDGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJU1</accession>
    <name>I1RJU1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG04123.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T14545</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NCF2/NOXA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321513.1">
        <property type="nucleotide sequence ID" value="XM_011323211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJU1"/>
    <dbReference type="STRING" id="229533.I1RJU1"/>
    <dbReference type="EnsemblFungi" id="CEF79075">
        <property type="protein sequence ID" value="CEF79075"/>
        <property type="gene ID" value="FGRRES_04123"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04123"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14545"/>
    <dbReference type="eggNOG" id="KOG4225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020375_0_0_1"/>
    <dbReference type="InParanoid" id="I1RJU1"/>
    <dbReference type="OrthoDB" id="9450131at2759"/>
    <dbReference type="PHI-base" id="PHI:6573"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06408">
        <property type="entry name" value="PB1_NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000017">
        <property type="entry name" value="NADPH oxidase regulator NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051864">
        <property type="entry name" value="NCF2_NOXA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034892">
        <property type="entry name" value="PB1_NoxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175">
        <property type="entry name" value="NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175:SF0">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN C23A1.17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="9">
        <location>
            <begin position="420"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="244"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF79075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="509" mass="57546" checksum="34C60FF86B7FD287" modified="2012-06-13" version="1">MSLKQEIETWVAALGRYDNNEFEEALNEFGKIGDTSKILFNMGVIHATLGEHEKAVESYQRAIRLDQYLAVAYFQQGVSNFLLGDFEEALANFNDTLLYLRGNAMIDYAQLGLLFKLYSCEVLFNRGLCYIYLQQMDAGMQDFSYAVKEKVVEDHNVIDDAINEQAEGYTVFSIPVGVVYRPNEAKVRNLKTKDYLGKARLVAASDRANAFTGFAGSEIKNAGKLEVKDDRPADNISFAATNLVKPGLSSRRQQSEPPNGRNVFPPTPPPENERPSRAASVRNQKPQLAKLNIQQAEPNRRYEKAASPADARRPMPRSASTTRTPLQREPPPLQLRPKQIPEETGSPEDVYAMYSATDGYRNSRGSAGSRRLRPQQYSEEEDASDYEGTINENDFEMIGQRRGPGSVSGSRNSRRTEVTKIRVKVHADEVKLIMITPDTRFETLSDKVRDKFNIKRRFKIKVKDDDMPNGDMITVGDQDDLEMVIDSVKDEARKQRTETGKMEIWILQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I1RK78</accession>
    <name>I1RK78_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG04272.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T14893</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321346.1">
        <property type="nucleotide sequence ID" value="XM_011323044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RK78"/>
    <dbReference type="FunCoup" id="I1RK78">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RK78"/>
    <dbReference type="EnsemblFungi" id="CEF79248">
        <property type="protein sequence ID" value="CEF79248"/>
        <property type="gene ID" value="FGRRES_04272"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04272"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14893"/>
    <dbReference type="eggNOG" id="KOG4313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048013_0_0_1"/>
    <dbReference type="InParanoid" id="I1RK78"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031804">
        <property type="entry name" value="DUF4743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
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        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF15916">
        <property type="entry name" value="DUF4743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nudix"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="139"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF79248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="332" mass="37956" checksum="C92F8C3DC3E3A382" modified="2012-06-13" version="1">MAKANINLIDEVDAFPYAETDPDAFAKMKEGLYNLVWEDSQGTYPIGYVLDRVVKELHQVPEDIRGKMVCNEAERTILLFQEPTEEERTRRVATLADYWRQNGTFPLLRGWRNELWPVYGRTGELLFSMERAAMGLIGTMRYGVHMVAYVKDKTAPHGLRLWVPTRARNKSTFPSMLDNTVAGGLMTGEDPFECVIREADEEASLPDSIVRKNAKFVGNVTYIYITDEGHVGEGDFIYPECQWVYHLELSNDVIPQPSDGEAERFDLCDVDQVKADLAAGRFKPNCALVTIDFFIRHGIMTDENEPEIEQIKQRVRRNISFPGPHRSDWCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RKL0</accession>
    <name>I1RKL0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG04421.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T15247</name>
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    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321184.1">
        <property type="nucleotide sequence ID" value="XM_011322882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RKL0"/>
    <dbReference type="STRING" id="229533.I1RKL0"/>
    <dbReference type="EnsemblFungi" id="CEF79424">
        <property type="protein sequence ID" value="CEF79424"/>
        <property type="gene ID" value="FGRRES_04421"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04421"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15247"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010578_0_0_1"/>
    <dbReference type="InParanoid" id="I1RKL0"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF146">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF79424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="456" mass="51741" checksum="C946A5D3401BEEE1" modified="2012-06-13" version="1">MTSSSPSERASALVQWATSNGATINPSVQVSHLPETGLSFCATAPTSPFDTIVSIPPTLTLSYLDTLPGRDDPKPFSSNFLVKTPPHVIGRFVLIKHFLLRESFWTPYIQALPQPNDVDSWSLPPFWPDEDAELFEGTNIEVGVANIKANVMREFRAGCDLLDRDDWEPQLLKQFTLPLYQWAYSIFSSRSFRPSLVLGPEDQQRLPEGVKLDDFSVLMPLFDVGNHDMTTQVRWERDEKSSDCSLKVGKAYQPGEQIFNNYSMKTNAELLLGYGFMLPETEELHNDYVHVRKRQPAQGEATEEYYISLRPIRHASSLLARSKQAVQLDDSTSVLGAFQHVQHDMVWDIFCTLAPPEQRAQFICEGSEQEQQNKFFSGQVSEDGRMFMQQTAAIIQHKVMQELERLLETDVEVVGGGDLTRNQQLALDYRARCKKVLETTLEAMDMDELFGEDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1RL07</accession>
    <name>I1RL07_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG04581.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T15629</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321003.1">
        <property type="nucleotide sequence ID" value="XM_011322701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RL07"/>
    <dbReference type="STRING" id="229533.I1RL07"/>
    <dbReference type="EnsemblFungi" id="CEF79614">
        <property type="protein sequence ID" value="CEF79614"/>
        <property type="gene ID" value="FGRRES_04581"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04581"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15629"/>
    <dbReference type="eggNOG" id="ENOG502RMDF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164184_0_0_1"/>
    <dbReference type="InParanoid" id="I1RL07"/>
    <dbReference type="OrthoDB" id="2269373at2759"/>
    <dbReference type="PHI-base" id="PHI:1817"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF79614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="113" mass="12802" checksum="45363E1C80BEF55F" modified="2012-06-13" version="1">MASDQQRPPRVLACVLCQQRKKKCDRKSPCSFCVKAGIQCIPSTPAPKRSRRKPTKELLARLERCEELLKRCTCVQKSLMYSSYEHRDMASPTYTSTDGSNGSSSPEREKMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RL81</accession>
    <accession>A0A098DP30</accession>
    <name>I1RL81_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG04665.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T15835</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320903.1">
        <property type="nucleotide sequence ID" value="XM_011322601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RL81"/>
    <dbReference type="SMR" id="I1RL81"/>
    <dbReference type="STRING" id="229533.I1RL81"/>
    <dbReference type="EnsemblFungi" id="CEF79716">
        <property type="protein sequence ID" value="CEF79716"/>
        <property type="gene ID" value="FGRRES_04665"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04665"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15835"/>
    <dbReference type="eggNOG" id="KOG2404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011398_4_6_1"/>
    <dbReference type="InParanoid" id="I1RL81"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006130">
        <property type="entry name" value="PRK08274.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF7">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="5">
        <location>
            <begin position="9"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF79716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="527" mass="57456" checksum="09384CB4F5F49467" modified="2012-06-13" version="1">MAHLPENVDVLIVGSGNAGFAAALSAAENGAKNILLIDKCPEEWVGGNSYFTAGAYRIAHGGLNDLLPFVNNVSREQAGKIDLAPYTEKDFQDDMDRVCMGRSDPELAKTLIQNSNSTIKWLASNGIRFQLSFNRQAYEVDGRIKFWGGLHIKTQDGGKGLIEDYLAAIKRRGVQVSWSTALTGLQKHSTDDSYDVQLLVNDHKRSLKASAVVLAAGGFESNPQMRSQFLGAGWDMAMVRGTPYNTGDVLNLAIEQLGGKAVGNWSGCHSVAWDANADPNTGDREASNEYTKSGYPLGLMLNVDGQRFVDEGVDLRNYTYAKFGRAILQQPEQLAFQVWDSRTMDWLRMEEYREERVERIFAKTVDELAQKCAERGLRDKSAFVDTIREYNEAVYAHRLENPDAKWDPAIRDGVSTQSSKKKLALAKSNWALPLDKGPYMAVKVTCGITFTFGGVKVDPQSAQLIHGVTGSPVPNVFVAGEMVGGLFYSNYPGGSGLTSGAVFGAKAGKAAANVVAKRQAQSLSSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1RLS6</accession>
    <name>I1RLS6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T16585</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CEF87260.1"/>
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        <location>
            <begin position="1"/>
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        </location>
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    <feature type="chain" id="PRO_5010124387" evidence="2">
        <location>
            <begin position="23"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
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    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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    <dbReference type="EMBL" id="HG970334">
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    <dbReference type="EnsemblFungi" id="CEF85859">
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="65"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF85859.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF85859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="331" mass="36908" checksum="253724B585895F52" modified="2012-06-13" version="1">MSKRPAEESLDEPRKRVQVATVASVAPGISRWSSTEIPDGLPPLPPINPDLEAQVFRHPGLGGPNWEKLEWYGDATLEMISTEFIFETFPHLPSGRCSQIREQLVRNVTLAGYYREYGMEHKTQLPIDVGKMTVLLQTQKNNKDVIKLQGDVFEAYVGAVVKSHPQGNANAVAWLKMLWGRTIKGQIQQAESYREIIAQAQPIITQQSPTMQEQSTQPEAKAVEPLTEQNAKARLSTAIAVPGVKLRYEDMPCKRKDRDTGLPLFAIGVYLDGWGETNKQLAFGVAKRKAEAGGKAALQVLKNEKVMKVYEAKKKQWLEEKAESRKAESGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RPP4</accession>
    <name>I1RPP4_GIBZE</name>
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            <fullName evidence="4">40S ribosomal protein S25</fullName>
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        <name evidence="6" type="primary">FG06020.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T19303</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324639.1">
        <property type="nucleotide sequence ID" value="XM_011326337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RPP4"/>
    <dbReference type="FunCoup" id="I1RPP4">
        <property type="interactions" value="928"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RPP4"/>
    <dbReference type="EnsemblFungi" id="CEF87022">
        <property type="protein sequence ID" value="CEF87022"/>
        <property type="gene ID" value="FGRRES_06020_M"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06020"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19303"/>
    <dbReference type="eggNOG" id="KOG1767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129470_4_0_1"/>
    <dbReference type="InParanoid" id="I1RPP4"/>
    <dbReference type="OrthoDB" id="10263513at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF87022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="94" mass="10485" checksum="42DF1EC25F6AA104" modified="2012-06-13" version="1">MAPAAKKQKKKWSKGKVKDKAQHAVVLDKTTSEKLYKDVQSYRLVTIATLVDRMKINGSLARQCLADLEEKGIIKPVVTHSKMKIYTRAVGGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I1RPT2</accession>
    <name>I1RPT2_GIBZE</name>
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        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG06061.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T19393</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF85921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324683.1">
        <property type="nucleotide sequence ID" value="XM_011326381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RPT2"/>
    <dbReference type="FunCoup" id="I1RPT2">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RPT2"/>
    <dbReference type="EnsemblFungi" id="CEF85921">
        <property type="protein sequence ID" value="CEF85921"/>
        <property type="gene ID" value="FGRRES_06061"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06061"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19393"/>
    <dbReference type="eggNOG" id="KOG3386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079690_0_2_1"/>
    <dbReference type="InParanoid" id="I1RPT2"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF79">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF85921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="182" mass="19845" checksum="7381A597FBC00703" modified="2012-06-13" version="1">MDHGAMGGDGAACKVEMLWNWNTIDACFLASSWQIKNQGMMAATCIGVILLVILVEFFRRLGKEYDALLQRGFQRQASTHSVALAAAGCTGAVVPTRQTLTYRASPLQQFIRAFIHAATFAGAYIVMLLAMYFNGYVIISIFIGAGLGKFFCDWLVVRIDLEGLEGPEDKSKGIEETTVCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1RPV3</accession>
    <name>I1RPV3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG06083.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T19443</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF85853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324706.1">
        <property type="nucleotide sequence ID" value="XM_011326404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RPV3"/>
    <dbReference type="STRING" id="229533.I1RPV3"/>
    <dbReference type="EnsemblFungi" id="CEF85853">
        <property type="protein sequence ID" value="CEF85853"/>
        <property type="gene ID" value="FGRRES_06083"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06083"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19443"/>
    <dbReference type="eggNOG" id="ENOG502T0A1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028978_0_0_1"/>
    <dbReference type="InParanoid" id="I1RPV3"/>
    <dbReference type="OrthoDB" id="4582561at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF85853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="648" mass="71787" checksum="30F8970570E85CB9" modified="2012-06-13" version="1">MASTPVVQSLSTTTSAAWSSIPSTTASDTPLTVLVRRSIDGTSDFFPFLDIAGLGSGSDDVDSGLTFKELFATNLDGGQEIILFSSGCQIDGVADCTRACNSSNLFFSSLETFYNCAALAAASHWTQESGPYYVSEETERNASAVMGSGTLAEFDGRPVLKSLIACAQDSCENDGLSKPCNRSIDRLSYGESTPEEIFEALDEFCPELPAEVNPDIFGPGVLISYVLQVCFAATLYLLLKGFTLWVTITQDTSRRKSEPKPYRLKRSLTRIESMIWRDSGGLSRTSIAIATTLVEFQEAQCWFVFAVQIASILAIVVNSQEGTFWGEIVVNGAIAYHVSQNGILPMFLIQICLHHEGIRNWHTFLGFFMEYLLAIVATSQKIYFKDAFALFKGQNEIKACGFNPSPRTYCAATQGIDGQGFSFFPHPLLYKMTFLILDTIAIVALVADQLAWTLRKHHLTKHVQFGSYRLGRWPRWGKQRRGLFIKIWFWRILEVAYLVINILYMISLTKVINAESFAANRWSYGQIIAVTVWGPVIVKLFDLLLSGPPKNGMRLNSGPPRLRIDNVINGRVGTSADECVIDDDNETDDKCDGPLSRPGRQEFRIRGSDTLQLGSPSRELQREEVIEGERSVATSDDMWSRGSVKKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1RPX0</accession>
    <name>I1RPX0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG06102.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T19493</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324726.1">
        <property type="nucleotide sequence ID" value="XM_011326424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RPX0"/>
    <dbReference type="STRING" id="229533.I1RPX0"/>
    <dbReference type="EnsemblFungi" id="CEF88860">
        <property type="protein sequence ID" value="CEF88860"/>
        <property type="gene ID" value="FGRRES_06102"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06102"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19493"/>
    <dbReference type="eggNOG" id="ENOG502S447">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138059_0_0_1"/>
    <dbReference type="InParanoid" id="I1RPX0"/>
    <dbReference type="OrthoDB" id="5593278at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018788">
        <property type="entry name" value="Proteasome_assmbl_chp_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF88860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="147" mass="15964" checksum="8CC1DAC0D21AF222" modified="2012-06-13" version="1">MDSIDVREDSFPSRSREISGQVNGVATEITSTSFTDKILITISQEGRLSQWIQVPLTGSSSGVVEMNLPSSNKGLLPSTHLTPTTLFGGGGEERETLGQLYAAQIASQICLRSPDDRRILVLGLGLAKTDLEREAFFDLLELVQQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQ88</accession>
    <name>I1RQ88_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG06227.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T19807</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324872.1">
        <property type="nucleotide sequence ID" value="XM_011326570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQ88"/>
    <dbReference type="FunCoup" id="I1RQ88">
        <property type="interactions" value="208"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RQ88"/>
    <dbReference type="EnsemblFungi" id="CEF88150">
        <property type="protein sequence ID" value="CEF88150"/>
        <property type="gene ID" value="FGRRES_06227"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06227"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19807"/>
    <dbReference type="eggNOG" id="KOG3786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025849_2_0_1"/>
    <dbReference type="InParanoid" id="I1RQ88"/>
    <dbReference type="OrthoDB" id="2186602at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11990:FF:000003">
        <property type="entry name" value="Pol II transcription elongation factor subunit Cdc73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="6">
        <location>
            <begin position="235"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF88150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="410" mass="45291" checksum="48AB55463FE29D80" modified="2012-06-13" version="1">MASAADLDGLVLLRQSISSGAPFIPSASADASATEVPLSQATNLRFPNQNITVPIDGPTRFVSHDKPVDLRSIYFAWLNREVAIPEYNASATKLNDELSAAGSSGKVQNLGFIERLDLITWLEGASEESEYIKPLANDKDAATTDAATTAKTGAVNSASQARSGRGTMDPRLVGIYNGERKMGDRNTVLRGAKPTDFSHVRKLAAPFIQKKSQSSSASIPTNPSLALNQKVPTRRPDPIILLSPSASSLIRLSNVRSFLEDGKFVPTDASGTTATMLHVQRLIPSIDPNRPMRFILVEGSEAFKPEYWNRIVAVLTTGQTWQFKNYKWSDPNELFKHTLGVYVGWRGETAPDNIRGWGHRVLSTGIDRWRGEGHDASRFRDKEIVEQIWRAIEENMRYRGWKKDRAPSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RRQ1</accession>
    <name>I1RRQ1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG06786.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T23183</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326436.1">
        <property type="nucleotide sequence ID" value="XM_011328134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RRQ1"/>
    <dbReference type="STRING" id="229533.I1RRQ1"/>
    <dbReference type="EnsemblFungi" id="CEF84621">
        <property type="protein sequence ID" value="CEF84621"/>
        <property type="gene ID" value="FGRRES_06786"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06786"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23183"/>
    <dbReference type="eggNOG" id="KOG1430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045518_0_1_1"/>
    <dbReference type="InParanoid" id="I1RRQ1"/>
    <dbReference type="OrthoDB" id="6235964at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000357">
        <property type="entry name" value="Methionine adenosyltransferase 2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD-like substrate binding" evidence="1">
        <location>
            <begin position="5"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF84621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="319" mass="35072" checksum="49DB3FAA94D6A64F" modified="2012-06-13" version="1">MTDRTVLVTGATGLLGREVSAAFGLKNWEVKGTGFSRADGISTFKVDLGNENEVSTFLDETKPQVIVHCAAQRFPDKVDKDPEGARALNVAASKALAKLAAERDTFVIYISTDYVFPGVPGDAPYEADAEPRPTNLYGQTKLDGERAVLETFKEAGKEGLGVVLRVPVLYGNAETPSESAVNVLMDALWKAQTQGAQISMDHWAIRYPTNTEDIGRVCHDISVKYLDTPSNNRASLPNILQFSSEDRMTKYEIVALFGEIMGLSTEGITPNTEGNDRNASVQRPYDCHLSTKALKDLGIDVSTCDFKGWWRREVRAFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>I1RRZ6</accession>
    <accession>A0A098DS69</accession>
    <name>I1RRZ6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">FG06900.1</name>
        <name evidence="18" type="ORF">FGRAMPH1_01T23455</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="19">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="19">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + AH2 + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + A + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the MoaC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326566.1">
        <property type="nucleotide sequence ID" value="XM_011328264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RRZ6"/>
    <dbReference type="STRING" id="229533.I1RRZ6"/>
    <dbReference type="EnsemblFungi" id="CEF84212">
        <property type="protein sequence ID" value="CEF84212"/>
        <property type="gene ID" value="FGRRES_06900"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06900"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23455"/>
    <dbReference type="eggNOG" id="KOG2876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_7_2_1"/>
    <dbReference type="InParanoid" id="I1RRZ6"/>
    <dbReference type="OrthoDB" id="429626at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21117">
        <property type="entry name" value="Twitch_MoaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="entry name" value="Molybdopterin cofactor biosynthesis C (MoaC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_B">
        <property type="entry name" value="MoaC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040064">
        <property type="entry name" value="MoaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="MoaA_twitch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047594">
        <property type="entry name" value="MoaC_bact/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050105">
        <property type="entry name" value="MoCo_biosynth_MoaA/MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006870">
        <property type="entry name" value="PRK09364.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960:SF0">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01383">
        <property type="entry name" value="cyclic_pyranopterin_phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01386">
        <property type="entry name" value="main_SPASM_domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="Molybdenum cofactor biosynthesis protein C, MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="17">
        <location>
            <begin position="79"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CEF84212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="650" mass="72271" checksum="A2DAF9E3002750B6" modified="2012-06-13" version="1">MSTRILSSRVSALGLTSGRRASMRPLAFTSRTVATATVVVAPQERPRDPSSSTPEIDLLQPQRRRIKDPKPFSDFLTDNFNRQHDYLRISVAERCNLRCVYCMPEEGVPLSPDRELLTTPEIVLLSSVFVSQGVSKIRLTGGEPTVRRDILPLMRQIGELRQHGLKELCITTNGISLHRKLGSMVESGLTGVNLSLDTLDPWQFQIMTRRKGYDAVQKSIDRILEMNRLGAGIKLKINCVVMRGVNDREVLPFVDMTQEKDIEVRFIEYMPFDGNKWSKNKMFSYQEMLDLIRTKYPTLQKVQDHKNDTSKTWHVPGFAGRIGFITSMTHNFCGSCNRLRITGDGNLKVCLFGNAEVSLRDILRKSNSGEPVDEQAFEAMKQIEMARRRDLLTSDRTPLGLAPNEMELLEVIGAAVKRKKAKHAGIGELEHMKNRPMILIDSTSQSPSSCNMPPRVQSLLRNGHFFTHGPSSFSQQRLFSQTRHAKSQDDSNKAKLTHVSSSGEARMVSISEKTVTSRIAKAACTVRFSNGTAIGLIRDNQMKKGDVLGVARIAGIMASKRTPDLIPLCHPIALSKATVDLDVRGDDRIEIAATVTCDGKTGVEMEALTAASTAALTVYDMCKAVDKGIVIEGLRVVLKDGGKSGRWEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>I1RS41</accession>
    <name>I1RS41_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG06948.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T23579</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326621.1">
        <property type="nucleotide sequence ID" value="XM_011328319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RS41"/>
    <dbReference type="FunCoup" id="I1RS41">
        <property type="interactions" value="961"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RS41"/>
    <dbReference type="EnsemblFungi" id="CEF85425">
        <property type="protein sequence ID" value="CEF85425"/>
        <property type="gene ID" value="FGRRES_06948"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06948"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23579"/>
    <dbReference type="eggNOG" id="KOG2002">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003008_0_1_1"/>
    <dbReference type="InParanoid" id="I1RS41"/>
    <dbReference type="OrthoDB" id="343875at2759"/>
    <dbReference type="PHI-base" id="PHI:1529"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031101">
        <property type="entry name" value="Ctr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="799"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="842"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="998"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="998"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1058"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1104"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1119"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1179"/>
            <end position="1188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF85425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1219" mass="137445" checksum="0AD131F5F09CE8EE" modified="2012-06-13" version="1">MSSSQNSTTNGVNGDAQSAPVSTRFSDIPSAIDIPIPSGEADEAVEINLEDLVDEPADLCTLLENENAAKTYWMTVALAYAKQHKVDHAIEMLQRGGNEIQKNSANPRDRVSMVCCLCWMYLWKSREAPRVAPEGTPVSEAKTKEYYLQLATSSLNDAARLNPSFPPIFLARGVLLLLRASLQAPSKTAGGIGSEKHELLKTAVKSFDDALRVSQGKNMLALMGKARALFSMHKYPESLTIYQDVLQKMPDLVDPDPRIGIGCCFWQLGFKDDAKMAWERCLEINPNSKVANILLGLYYLDASGHVPVNSDNFLKLYKKAMTEYAQKSFKLDKDVPLTCSTFSGYFLSRKAWDNVDKLAHKAIQYTDVNAIASDGWYLLARKEHYTGDIERAADYYRRADEARGGTETGYLPAKFGVAQLSVMKNDLGEAKLRLEKMIQQSKNHEAMILLGTLYAEEVFANQVSDSKEDKSAELKKAITLLESVRNAWKDPKRALSPDASVLLNLARLYETDQPDKALQCLQQVEQLELDQVPDSEQPEDVTDAAEIKAALRKSLPPQLLNNIGCFHSQAEKHELASDMFEAALGACIKIGEKDPDMDTDALVSTISFNLARSYESRGLTDKATEVYEGLLARHDDYTDARARLAYIKLRKNPNKEGPDAVAKLYQENNTDLEVRALYGWYLGKVHSRKRPANLNEDAEFRHYKHTLQNYDKHDRHALVGMGNLYLMQAREMRRESDSDKQKRSAIYAKAVEFFEKALSLDPKNAYAAQGIAIALVEDKKDHKSALGIFNKVRETLRDSHLYVNLGHIFAELRQYSKAIEHYEIALSKDGKKDDPTILACLGRTWLNRGRAERDVDSYNKALECAQKALGVAPEQVHYKFNVAFVQIQLVTLVQGLPENKRSTEQLEKAAEGLESAITSLDEIAAHPQTPYPKNDVEQRANMARNTLRNQLQRAIGKQKEWEEKNKEKIQAAKELREAEVRRREEERQKIVELERERQEKIKKERDEIAKKDRALAAQRAEEEQARMEAEMTTDSETGDKVKRKRKTAPRASGEPKPKRSGGGKKKKKSEHQDDESEEEEERTKKRRRLTKKESAKFKSAEIVVDSDEENNNDDDELERAERNIDREETPLSEIDEKVVEDDKMDVDGGAEQGGDDDDEEEIAPRQQNKRARRGRVVSDEEDNDDEEAPTQAKTASGDEDDEPRPAADTSMADAADDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1RSX4</accession>
    <accession>A0A098DVS0</accession>
    <name>I1RSX4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG07261.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T24369</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326999.1">
        <property type="nucleotide sequence ID" value="XM_011328697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RSX4"/>
    <dbReference type="FunCoup" id="I1RSX4">
        <property type="interactions" value="244"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RSX4"/>
    <dbReference type="EnsemblFungi" id="CEF85457">
        <property type="protein sequence ID" value="CEF85457"/>
        <property type="gene ID" value="FGRRES_07261_M"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07261"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24369"/>
    <dbReference type="eggNOG" id="KOG3035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051989_0_0_1"/>
    <dbReference type="InParanoid" id="I1RSX4"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF85457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="269" mass="29802" checksum="44A5D0CD1509FE54" modified="2012-06-13" version="1">MASTVPQVVLFGDSLFQQCSDLQEGFSFQAALQSDFIRRLDIVNRGYSGFNTDIALRYLPEIFAERTTSSPKMDYLVLLFGANDAVLPDAFTKQHVPIDRYKKNLTQIVNHPRIAAHKPQILLVTPPPLDEIKATPRSIANGHKGAVRMSTVSAAYSEVAREVARENPGVILVDLWKGLMDEAISLAPSDYTPDGPWLGDPKNGKQGGLDSLLHDGLHMSGAGYQVFYETLKPFIGKEWHGLPGEDRRGFVIPDWRELLELQADLNTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RU01</accession>
    <name>I1RU01_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG07671.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T25345</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327463.1">
        <property type="nucleotide sequence ID" value="XM_011329161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RU01"/>
    <dbReference type="SMR" id="I1RU01"/>
    <dbReference type="EnsemblFungi" id="CEF83226">
        <property type="protein sequence ID" value="CEF83226"/>
        <property type="gene ID" value="FGRRES_07671"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07671"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25345"/>
    <dbReference type="eggNOG" id="ENOG502RPSG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029538_1_2_1"/>
    <dbReference type="InParanoid" id="I1RU01"/>
    <dbReference type="OrthoDB" id="5382058at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013433066" evidence="1">
        <location>
            <begin position="17"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="166"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF83226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="459" mass="50441" checksum="BD335FA10A6884FA" modified="2012-06-13" version="1">MLSKILISALLSGALAAKQETLPYADEPNRCDTTCQLAYRQALTGESNLWVNQNVSTDPFYSNPANMSDYAAGDLVKWEEIPSVQTTRRWTIPGSVTLNRYFYMTEDINGKPIPATGFVMIPYANPLGNDKPFRTLVWTHGTAGGTRQCAPTNHRGLYYEWQAPFELVLQGYVVIAPDYAGQGSDIPEGFMYESGALHAGDVSFGLQAARKALGNKITKEWVVIGHSEGGMTAWRTDEREAMKGKATGGFLGAVAMAPALQPIKLIPESFRRAGDGPAGDVVSIFLLQSLSRLYPEIKVEDYATDIVMSRIPLADQGCLATGGSLYGNLTVKELYKNTSWVEHPAMVDWQKRFNGAGSHKLAAPMLVVQGEADILTYPEYAVEDFDAKCKEFPESTAEYRSYPGLDHGAVLHAAKVDYLPWIADRFNGVKIAKGCKKVTVKPATDRFSLVTQDWMALIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RVX8</accession>
    <name>I1RVX8_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="19">ETF-QO</shortName>
            <ecNumber evidence="19">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">FG08425.1</name>
        <name evidence="21" type="ORF">FGRAMPH1_01T09927</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="22">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="23">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="22">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="21 23" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="21">PH-1</strain>
        </source>
    </reference>
    <reference evidence="22" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 19">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="19">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ETF-QO/FixC family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="19"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320349.1">
        <property type="nucleotide sequence ID" value="XM_011322047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RVX8"/>
    <dbReference type="FunCoup" id="I1RVX8">
        <property type="interactions" value="723"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RVX8"/>
    <dbReference type="EnsemblFungi" id="CEF76766">
        <property type="protein sequence ID" value="CEF76766"/>
        <property type="gene ID" value="FGRRES_08425"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08425"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09927"/>
    <dbReference type="eggNOG" id="KOG2415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="I1RVX8"/>
    <dbReference type="OrthoDB" id="437331at2759"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000015">
        <property type="entry name" value="Electron transfer flavoprotein-ubiquinone oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 19" id="KW-0408">Iron</keyword>
    <keyword evidence="14 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 19" id="KW-0813">Transport</keyword>
    <keyword evidence="15 19" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="594"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CEF76766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="634" mass="70324" checksum="997A68C7ED364C46" modified="2012-06-13" version="1">MPAPRPVSRCVQRSSQVLSRTQLRPARSTFSPATIAARSSLTRRTSTALWSAAKVPMAARAFSTTSRLRDDDTDFDPATVERESDEVDVCIVGGGPAGLSAAIRLKQLANDAGNEDFRVLVLEKAGDLGAHILSGAVIQPTAINELFPDWLDENNPNRFEHATPAGTDRMRFLTKNSAIPIPAPPQMTNHGNYIVSLNQFVKWLGERAEEIGVEVYPGFAASEVVYHADGSVKGVATNDLGVGRDGKPKETFERGMEFHARVTMFGEGCHGSLSKQVINKFDLRRDSQHQTYGLGVKEVWEIDPAKFEKGLVVHSMGYPLPKDVYGGSFMYHFGENLVQIGLVTSLDYTNPWMSPYQEFQKLKRHPLFRDVLEGGKCISYGARALIEGGFQSIPKVAFPGGALIGDSAGFVNVPKVKGTHNAMKSGMLAAEAAWTALSEKTDEGTVFLYDYENKLRDSSIWKELHEVRNMRPSFHTPLGLYGGIMYSGLEAYVFKGRVPWTLKHKTPDHASTLHADKVPKIEYEKPDGKLTFDILTSVSRTGTNHEEDQPVHLQVKDWDAHTESTYPPYKGMENRFCPAGVYEYVEDESKPHGVRFQINAQNCIHCKTCDIKAPHQDINWQVPQGGEGPKYYMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>I1RWL6</accession>
    <name>I1RWL6_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG08691.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T10579</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320047.1">
        <property type="nucleotide sequence ID" value="XM_011321745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RWL6"/>
    <dbReference type="SMR" id="I1RWL6"/>
    <dbReference type="FunCoup" id="I1RWL6">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RWL6"/>
    <dbReference type="EnsemblFungi" id="CEF77092">
        <property type="protein sequence ID" value="CEF77092"/>
        <property type="gene ID" value="FGRRES_08691"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08691"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10579"/>
    <dbReference type="eggNOG" id="KOG0581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_79_2_1"/>
    <dbReference type="InParanoid" id="I1RWL6"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="PHI-base" id="PHI:1190"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990315">
        <property type="term" value="C:Mcs4 RR-MAPKKK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF25">
        <property type="entry name" value="MAP KINASE KINASE PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="259"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="170"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="285"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="620"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF77092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="647" mass="68969" checksum="118750B1B77B24FE" modified="2012-06-13" version="1">MSASDSVPATPEDWKDLSTPGSPGSEDSSEPTTPLESPSHDSPSEPPRRVPSLRSVSDPRNMNPNSTPIGVLGIARRPVQPSFSFAGNSSASVENSAMAKARALHQQRLQKGNSASPVGQSPTSSISNGFPVNLRMPPNMQRPQPPHANSAPVVSKPSLSERRAKMGMGMKLSDMGGSSPAATTGKRGPPGKLSDITGDAPSNKESNGTGGGHGSKMDDFKKYIDTEKGWVTFDGAATITRTGVNFANGQTFSISLDEVEVLTELGKGNYGTVYKVKHAKRSLPRFGQGLSRKPPAVQYTQSDPSPVRPVEDSAGGQSNSGDGTTGTVMAMKEMRLELDDAKFTTILKELVILHECVSPYIIEFYGAFFQEGAVYMCIEYMDGGSIDKLYAGGIPENVLRKITYSTVMGLKSLKDEHSIIHRDVKPTNILVNTRGQVKICDFGVSGNLVASIARTNIGCQSYMAPERISGGGYAQAGNSDGSYSVQSDVWSLGLTVIECAKGAYPYPPEVSSTIFSQLSAIVEGEPPAMPEEGYSDTATDFVRSCLHKIPKQRPTYAMLLKHPWLIDFTKPQTITEEAEDGDEADKVAEAVGKIALNSTTEDAEVADWVNGVLQKERDGLKVGGPLRPALHTAPLDSVSPISSPNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1RX05</accession>
    <accession>A0A098DE98</accession>
    <name>I1RX05_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG08846.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T10981</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319866.1">
        <property type="nucleotide sequence ID" value="XM_011321564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RX05"/>
    <dbReference type="STRING" id="229533.I1RX05"/>
    <dbReference type="EnsemblFungi" id="CEF77293">
        <property type="protein sequence ID" value="CEF77293"/>
        <property type="gene ID" value="FGRRES_08846"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08846"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10981"/>
    <dbReference type="eggNOG" id="ENOG502QUTZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_562637_0_0_1"/>
    <dbReference type="InParanoid" id="I1RX05"/>
    <dbReference type="OrthoDB" id="5151590at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="488" mass="54501" checksum="D31B153CAE921B29" modified="2012-06-13" version="1">MARYTHSPSGSISGSISGSTRSLSATPPPAHDPLFFTYLIDKRFGLDRTKDGPMDELQAWAMNYNKQLNPQQIQSTQQYDQIAALQGMTSGLFAAPQDPQLIRNVGQAEQLLAASTLPTGAQVLGAEILHAQGWSREAVANQVQYQLPDQVAAESAPRLALRPKTRAQARLKARSKVTPSSSTLSLSIRPKHPPTLTNDQIRQLVEFIESNPNARRTPMADIPSVLGFDCSEQTIITALGRKGFKSSPAITRPRIDEKTRQMRLHFAQSYCHWTAEQWESVVFYAEMRVPLKEQPQQVFVTRKSDEDVHPDCINFEPVAPPDYTNSNVYFAYLSGVAGLGRLPSWNRHSSRVHGSLSPESWYLNIFPSLVDFLQDHSGGPRFALSPDLPAHCNVTIRDELRSGHKPVLYMPPTSPDLNPITEIFGTMMANLKVDKANSLFGDVTDYRIDDVVRDTWQSISKEYLSELIGSMPERCQAVIDADGWYTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1RYN6</accession>
    <name>I1RYN6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG09493.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T26953</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328228.1">
        <property type="nucleotide sequence ID" value="XM_011329926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RYN6"/>
    <dbReference type="EnsemblFungi" id="CEF83798">
        <property type="protein sequence ID" value="CEF83798"/>
        <property type="gene ID" value="FGRRES_09493"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09493"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26953"/>
    <dbReference type="eggNOG" id="ENOG502RN6V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2084964_0_0_1"/>
    <dbReference type="InParanoid" id="I1RYN6"/>
    <dbReference type="OrthoDB" id="5083194at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF83798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="110" mass="12061" checksum="86BD6700BD10374D" modified="2012-06-13" version="1">MSFTRATRSLRKRLLGSKAFLPAHTAAASFRYSIPRSTAFHSHSHGKLKHQAQPAALGTVAVRGNGLTSGLESYAAMMEGDGCSRAGKHIGSFYQQWERGSFMIRKSKMM</sequence>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZ32</accession>
    <name>I1RZ32_GIBZE</name>
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            <fullName evidence="3">Chromosome 4, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328057.1">
        <property type="nucleotide sequence ID" value="XM_011329755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZ32"/>
    <dbReference type="KEGG" id="fgr:FGSG_09650"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26591"/>
    <dbReference type="eggNOG" id="ENOG502SCCN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074173_1_0_1"/>
    <dbReference type="InParanoid" id="I1RZ32"/>
    <dbReference type="OrthoDB" id="4991875at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640:SF1">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5010219481" evidence="2">
        <location>
            <begin position="18"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB65397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="227" mass="22550" checksum="CB05EBF6DB3E9152" modified="2012-06-13" version="1">MVRSLALFAGAIATVAAAQTTTVNFFLPGFDKQALVGSVVAVKGEATTVAISCPDGTDPSECGVQETRTIVGGASTMDISYSYSPPEEYGGGYMDNRTGCKLDPKKDVAFCSAEATEVISGVTESMAATTALSGYKQLIMPITITAGAEKLNGNAATATASASGSEATTADKPKDTGAQSTGSATTSGTDADATPSPVESDNAAGPMVTQNAILAVAAVVGGAAMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZ75</accession>
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        <submittedName>
            <fullName evidence="8">Chromosome 4, complete genome</fullName>
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        <name evidence="9" type="primary">FG09701.1</name>
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    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <name type="synonym">Fusarium graminearum</name>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
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                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
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    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_011329702.1"/>
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    <dbReference type="EnsemblFungi" id="CEF83948">
        <property type="protein sequence ID" value="CEF83948"/>
        <property type="gene ID" value="FGRRES_09701"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26485"/>
    <dbReference type="eggNOG" id="KOG0254">
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="MFS_1"/>
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    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF83948"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZ96</accession>
    <name>I1RZ96_GIBZE</name>
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        <name evidence="10" type="primary">FG09726.1</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
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    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
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                <consortium name="EnsemblFungi"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="47"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="473"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="518"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF83850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="596" mass="65580" checksum="85918F6EA9425396" modified="2012-06-13" version="1">MLTKGPLLDTTSLPLGQRRGISDLAQIALDLTWASESAKNDTIARYRAYPSPPMSGSPPLPPRQPQDSGDRRQPPVGYSAPNQPDTYWSNLSQQPPADNRGPPNMQTTLPRLFQQVPPDHSPFPYRRPDDPTSRHVSYIQSGAPPMSQQAGYIPPSAPGVSSPYASSARPSIVENQPMTSPKSQRKTKGHVASACVPCKRAHLRCDAQRPCSRCITNGKEDSCIDVQHKKRGRPRLRDDRETRYDPSRFPHPQDAAVRRPLSIYPSGTPMGPGGEHMNQRYSERTHNMEASTYPPHLPSGPRGADPVAFLNMKMDFAKASPAFMEAVGQAELQGQNLVDVVVLTEREKVASIRSQLIEEQTRKEPNYLPPILGRLDRILQGLGFGADEIGRFQLDRHEYLTFRAADGQPRQYPIRLGLAKEGTIYFIVMVLSVPVRHAYPLPSSPAAREAAHSYISQPPTPQSVYRTPVPPTTPFDMTRGPFNEVPLVSRPATGPSTQLPTSANHGIAVGAGAASYAASPGRTEYRPPQSYNVPRSELPPPSAYRPQATFQLPPIRAQPEHPGPRPTGDQKWPHEDRSTRVDIGGLIDKPENPAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZK6</accession>
    <name>I1RZK6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG09853.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T26125</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327827.1">
        <property type="nucleotide sequence ID" value="XM_011329525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZK6"/>
    <dbReference type="FunCoup" id="I1RZK6">
        <property type="interactions" value="957"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RZK6"/>
    <dbReference type="EnsemblFungi" id="CEF83400">
        <property type="protein sequence ID" value="CEF83400"/>
        <property type="gene ID" value="FGRRES_09853"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09853"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26125"/>
    <dbReference type="eggNOG" id="KOG3073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055846_1_1_1"/>
    <dbReference type="InParanoid" id="I1RZK6"/>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005880">
        <property type="term" value="C:nuclear microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF83400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="259" mass="28761" checksum="82CCEBF43DB93354" modified="2012-06-13" version="1">MSSPERRTAGVKRPRTQSLPPPSLPQLVAEQSTPIPPTDKDSQRLIVVLSNASLETYKASHGGTSRNREDKYSLLNSDEHIGVMRKMNRDISDARPDITHQCLLTLLDSPINKAGKLQIYIHTAKGVLIEVSPSVRIPRTFKRFAGLMVQLLHRLSIRSTNSNEKLLRVIQNPITDHLPPNCRKVTLSFDAPLVKVREYVESVNSKDSICVFVGAMAKGEDNFADSLVDEKISISNFSLSASVACSKFCHAAEDVWDIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1S0E8</accession>
    <accession>A0A098DC38</accession>
    <name>I1S0E8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG10172.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T07453</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319113.1">
        <property type="nucleotide sequence ID" value="XM_011320811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S0E8"/>
    <dbReference type="STRING" id="229533.I1S0E8"/>
    <dbReference type="EnsemblFungi" id="CEF75531">
        <property type="protein sequence ID" value="CEF75531"/>
        <property type="gene ID" value="FGRRES_10172"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10172"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07453"/>
    <dbReference type="eggNOG" id="KOG2582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028825_1_0_1"/>
    <dbReference type="InParanoid" id="I1S0E8"/>
    <dbReference type="OrthoDB" id="29061at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COP9 signalosome complex subunit 3 N-terminal helical repeats" evidence="3">
        <location>
            <begin position="35"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF75531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="490" mass="54321" checksum="60D041382F5B3D0B" modified="2012-06-13" version="1">MDAVTATLAAFSPTQAATESAKKYDSIIKEHIGAVKSLLSNQRQAINENTSQILQVIDPSIDSIAFLAILHSSLSSPTPPPGIDRRTLLDETLRFLLNFNPLQVRYVGVVFRKLLEHVAEGKLFTSAVSVEAVASALLRLDPTGSMFTSTHLALVKIAYQTTWIEPALKVLDCDTTFFPGTVGQKDSKPLCDSSLHSATFISVDTGLTESVKSTTILEYYHLSALCYMSQRDWTKAHRALEHVITYPSKDKGVAKIMDEAYKRWLLVGLLKDGKEPTLPSYTSLHAKNTYSTLGTPYQNIATQFATTNAGQLKADVEANRLVWEEDGTSSLIAEVIAAYQKWQIINLRDIYKRISISQLRQSTLSAETGENLPDDDTAIHIVREMIDSGLLKGDLESSNDGNELFLHFHDDSETMTEAEFAQEIAQRYHNIENLGKQYKAANERLSSSKEYVKHVVKEQRRADKDSGDPGVGFDSQIEDEDLMTGIMAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1S0S0</accession>
    <name>I1S0S0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG10307.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T07783</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319267.1">
        <property type="nucleotide sequence ID" value="XM_011320965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S0S0"/>
    <dbReference type="FunCoup" id="I1S0S0">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1S0S0"/>
    <dbReference type="EnsemblFungi" id="CEF75695">
        <property type="protein sequence ID" value="CEF75695"/>
        <property type="gene ID" value="FGRRES_10307"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10307"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07783"/>
    <dbReference type="eggNOG" id="KOG2248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022453_4_0_1"/>
    <dbReference type="InParanoid" id="I1S0S0"/>
    <dbReference type="OrthoDB" id="3996471at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF112">
        <property type="entry name" value="RNA EXONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="6">
        <location>
            <begin position="428"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="491"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF75695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="656" mass="72736" checksum="BC673A833BBE6A00" modified="2012-06-13" version="1">MSLSLKHIPCPKGNDCTAFHCIFGHPNENPPAPEVPSPKPSSNGQDKKDAPGGSQDAPRKRVRTDPFNPPKSPETSQEVGQSKPGASRSGSTDTNKKPATKTLVTKRQIPPSALKRKIDPQDNGPNASSKVAKTNQSSNESRPSPAQKSAPAKPKKAESLNPRLLKSMPASHDIRLKLVKMLHQEFTRLNKELKKSAKKDETNLLLSEQELIVRTLDTEEHVAVHKAAVYSNVMKNKVMQYKRMKVNQWKTERQEERKKLELESSGKDPSEQPKEIKTGLTPAQEVELAKHLLTPINELASHGYVSTVPSEEDIEKARQGVEASAGWEKCDRCQQRFEVFPGRREEDGALTSGGSCTFHWGKTFIAPKALGDRTRQPKRFQCCGQELGDSVGCFTRDHHVFKTSDPKRMASILNFAETPENPLAPKDRAVAFDCEMGYTVFGMELIRLTATSWPTGEELLDVLVRPLGEILDLNSRYSGVWPEDLAKAESWSANESTKSTKSDSDDTSEDGELKPKKKQLKIVSSPEVARDLLFSLISPTTPLIGHGLENDLNSVRIVHPTLIDTVLLFPHQGGLPYRFSLKMLMDVHLNRKIQQETGPKMLGHDSAEDARAAGDLVRLKIKNLWMDLQRNGWKLVDGKFVAPGKATGLTEAFIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1S0V4</accession>
    <name>I1S0V4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG10344.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T07873</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319308.1">
        <property type="nucleotide sequence ID" value="XM_011321006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S0V4"/>
    <dbReference type="STRING" id="229533.I1S0V4"/>
    <dbReference type="EnsemblFungi" id="CEF75740">
        <property type="protein sequence ID" value="CEF75740"/>
        <property type="gene ID" value="FGRRES_10344"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10344"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07873"/>
    <dbReference type="eggNOG" id="KOG3067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079179_0_0_1"/>
    <dbReference type="InParanoid" id="I1S0V4"/>
    <dbReference type="OrthoDB" id="829at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990605">
        <property type="term" value="F:GU repeat RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035939">
        <property type="term" value="F:microsatellite binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14819">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.200:FF:000002">
        <property type="entry name" value="Putative translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF75740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="249" mass="27768" checksum="BB5EBB974528BA2C" modified="2012-06-13" version="1">MSSETPLLDPSLFSHLQEKLDEETSVRDNLTQIIQRLERAVATAQGLLSRVHSTPRARYPALVSQVEDAIKEEVTIVKELSEVASQHPYYKYNQKWARTVQNAIGTAVYTAWLGGLGSDSQPASLGRLLTLEQVGAVFQVPTNLKDRDAFHFTIEEYLLSLTDLTNELARLAPNAVTHGDFELPLVISAFIKDLFAGFQLLNLKNDILRKRADAVKYDVKRVEDVVYDLSLRGLVKRPGEGDTEMAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I1S4A3</accession>
    <accession>A0A098CZA2</accession>
    <name>I1S4A3_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
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    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T00257</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF71928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315683.1">
        <property type="nucleotide sequence ID" value="XM_011317381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S4A3"/>
    <dbReference type="EnsemblFungi" id="CEF71928">
        <property type="protein sequence ID" value="CEF71928"/>
        <property type="gene ID" value="FGRRES_11670"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11670"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00257"/>
    <dbReference type="eggNOG" id="KOG3425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120161_2_0_1"/>
    <dbReference type="InParanoid" id="I1S4A3"/>
    <dbReference type="OrthoDB" id="78947at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF71928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF71928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="125" mass="14265" checksum="059FCE76CD957724" modified="2012-06-13" version="1">MPVLHEVQLSSPKSLVPLLTSDEPIYVILTSSNDEETGAPWCSDVRTALPYLKEVFDKPDGPKAIYESVGPRPGWRKPDNVHKRTWNISAIPTVIRFELRDGKVEETDRLTEAEVYEERKLQSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I1S4G8</accession>
    <accession>A0A098D145</accession>
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        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">FGRAMPH1_01T00687</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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        <property type="protein sequence ID" value="CEF72145"/>
        <property type="gene ID" value="FGRRES_11735"/>
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            <dbReference type="EMBL" id="CEF72145.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF72145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317381.1">
        <property type="nucleotide sequence ID" value="XM_011319079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S549"/>
    <dbReference type="STRING" id="229533.I1S549"/>
    <dbReference type="EnsemblFungi" id="CEF73716">
        <property type="protein sequence ID" value="CEF73716"/>
        <property type="gene ID" value="FGRRES_11967"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11967"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03821"/>
    <dbReference type="eggNOG" id="KOG0297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019709_1_1_1"/>
    <dbReference type="InParanoid" id="I1S549"/>
    <dbReference type="OrthoDB" id="1630758at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Znf_C3HC4_RING-type"/>
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        <property type="entry name" value="Znf_RING"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="Znf_RING_CS"/>
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        <property type="entry name" value="Znf_TRAF"/>
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    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF94">
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        <property type="entry name" value="TRAF domain-like"/>
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        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="161"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="7">
        <location>
            <begin position="299"/>
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        </location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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    <feature type="region of interest" description="Disordered" evidence="5">
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    <feature type="compositionally biased region" description="Low complexity" evidence="5">
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    <feature type="compositionally biased region" description="Low complexity" evidence="5">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CEF73716.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF73716"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
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</entry>
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    <accession>I1S5D0</accession>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317850.1">
        <property type="nucleotide sequence ID" value="XM_011319548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S5D0"/>
    <dbReference type="STRING" id="229533.I1S5D0"/>
    <dbReference type="EnsemblFungi" id="CEF74205">
        <property type="protein sequence ID" value="CEF74205"/>
        <property type="gene ID" value="FGRRES_12048"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12048"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04797"/>
    <dbReference type="eggNOG" id="KOG2304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017201_2_0_1"/>
    <dbReference type="InParanoid" id="I1S5D0"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF74205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="541" mass="60583" checksum="A3DE089BE9A7448F" modified="2012-06-13" version="1">MPIPVPLSLFIFPTINILLRIRFHSSQCQPVLLHVAPSSQAAMSAVDPALGATEIHLETHRRPAHDVGTGIRLVPFRTNTSSAKRKFRRSTTSRPSSDTPSTHASHVTEAPETHALRQARVFEADIAISGDTLTGSAVLESVSPPRYTNPSRGYVVNDSMEDLDTTWLDTLYREGFEVVFGSWMGSYSCPFLFGHTLADKYVSISDLCRHLDGCIVDSGNSQVAGRDEEAELSLQSTICAFAARWLPVTSAVESYQGHCNLVQSLWRHARRDMLRIINRPSYRSMLSLLLFALTPIPEGISEEEETDGISGQACVHAALQQIQNLRARQRNLQFSGSKVSPSLRSETIATTPESIESSGFINAESTVYWAALTFDTSASLTLNCRPLLSSGLFGFESELPWRLVRTCAKMFDENARQWKQASADMTDERANQIIAAGASWKLLGWKLTAIFKEALRDGHEEPEVRKAYFAVVDSIKQFGIVYRPLLDECHKRMPFLGQKTKLRWCRFSITLKWHRIDRNNSFSHAPLSPQHIDACRHNRSY</sequence>
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    <accession>A0A098D8T0</accession>
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            <fullName evidence="1">Chromosome 1, complete genome</fullName>
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            <taxon>Pezizomycotina</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317998.1">
        <property type="nucleotide sequence ID" value="XM_011319696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S5F0"/>
    <dbReference type="EnsemblFungi" id="CEF74361">
        <property type="protein sequence ID" value="CEF74361"/>
        <property type="gene ID" value="FGRRES_12068"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12068"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05111"/>
    <dbReference type="HOGENOM" id="CLU_1949003_0_0_1"/>
    <dbReference type="InParanoid" id="I1S5F0"/>
    <dbReference type="OrthoDB" id="3468019at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF74361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="129" mass="14414" checksum="9F58752C82D88BD2" modified="2012-06-13" version="1">MAEHIFACDDASLDPRIKHNLPLFYAAADTPNHELWCSFLTDDVVIKKGASEMKGKDGWTHSAVMAFRKVAKKEISESTDKSVTLDFRLSAYGQEKQLTLSAIQPYITCLISHVMLPTESQDVQSLILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1S686</accession>
    <name>I1S686_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
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        <name evidence="2" type="ORF">FGRAMPH1_01T13935</name>
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    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <name type="synonym">Fusarium graminearum</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321795.1">
        <property type="nucleotide sequence ID" value="XM_011323493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S686"/>
    <dbReference type="STRING" id="229533.I1S686"/>
    <dbReference type="EnsemblFungi" id="CEF78770">
        <property type="protein sequence ID" value="CEF78770"/>
        <property type="gene ID" value="FGRRES_12357"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12357"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13935"/>
    <dbReference type="eggNOG" id="KOG0692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044063_1_0_1"/>
    <dbReference type="InParanoid" id="I1S686"/>
    <dbReference type="OrthoDB" id="204377at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089:SF1">
        <property type="entry name" value="BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE_SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="SHIKIMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="1">
        <location>
            <begin position="14"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF78770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="305" mass="33812" checksum="2A170E05ED407E66" modified="2012-06-13" version="1">MDESQLQQPRRTYLFGYPLQHSLAPLLHSTIFESLNVPWTYDLIESIDKNDFIPKLKASDCVGAAVTMPHKVAWINECDEVTDEGRAIGAINTVFIRKDEVTGERKYIGTNTDCVGVRESFLQNSPGITEKSKGKPALVIGGGGACRSAVYALYKWLGASEIYLVNRLKEEADAVIESFSGLEDGPKMTYISSLEQAKQLETPVLIVGTIPDFEPSTEGEILARDIVTELVQKEEKGVLLEMCYHPRIVTRLYSLAEDNRWKVIPGTEAMIYQGIAQEVLWMQKPLSDMPLEAAKAAIAKVLGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1S709</accession>
    <accession>A0A098E2G6</accession>
    <name>I1S709_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T16449</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323296.1">
        <property type="nucleotide sequence ID" value="XM_011324994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S709"/>
    <dbReference type="EnsemblFungi" id="CEF87812">
        <property type="protein sequence ID" value="CEF87812"/>
        <property type="gene ID" value="FGRRES_12632"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12632"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16449"/>
    <dbReference type="eggNOG" id="ENOG502SNT2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_924520_0_0_1"/>
    <dbReference type="InParanoid" id="I1S709"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF87812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="301" mass="34720" checksum="2341AC69C8711F2C" modified="2012-06-13" version="1">MYTAIRFKEYANTDVTIRGLDAHPRRLSFLSLKLSILLMIYSFLSILVEDRRRSVLFHKKRDSGWSFVDITQPPGDSHLVFQFNELRNAIERDHATAGSAVLTFMVKFNILYSATPRYLRDSFLTYGKQASGSDVFYKLREWRQSRSSRSAIWHAGQLLRACRMIAPTERTDFHLFGVYHAILCLWTYWTATRKSSLDMTSTSRQTVSWPRVLLDGPESLETQRWINHNDGTPYLTRPPKSDPLCDKNPKLVSVDATESEGTFSKLPLVDILNECFLQKEAGRNIPILQHASLILRSLERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1S967</accession>
    <accession>A0A098DDS3</accession>
    <name>I1S967_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG08300.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T09599</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320493.1">
        <property type="nucleotide sequence ID" value="XM_011322191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S967"/>
    <dbReference type="EnsemblFungi" id="CEF76602">
        <property type="protein sequence ID" value="CEF76602"/>
        <property type="gene ID" value="FGRRES_13397"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13397"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09599"/>
    <dbReference type="eggNOG" id="ENOG502T1TT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044097_0_0_1"/>
    <dbReference type="InParanoid" id="I1S967"/>
    <dbReference type="OrthoDB" id="3557758at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="454" mass="49088" checksum="C372AC97231CD60B" modified="2012-06-13" version="1">MDTFRAGLEGKRLPSSKLRLPTTSNFLTRSKRKRPVVSAPIGPVKNSRGADFVRSDTLIIVPTIKDCCSDDSSSDKENAQAIKTTRRISASFSTHGSLASPPTVAKSGLTATSSHQSLLSAAPIKPLPTTASFTNFSRKTLANSSSYGVYPTVDTIFQDENVPPPDHKEVAPAETVSSTMNKSRLPKSRTLTVLSEIRSSISRTSMNSKPSSPRPLADQSRKASSSSTSSLLTSSSSRLCLPGYSSTSASRTNSTSTLVTELLPKPDQITSSQPSAYWSGRFVSLHDRFLTEEFSTEGAVSKDSSSDNSFRAFVMKTDRAAVNSRPTHLSHSTTTSALTSLTVTKPRNKTSTKDARCLRVFHHLENLCITIEARRSLLAWQQTYARRMDKPSLLPQGGSMEHKSLMGRIFSGGKGTSGNTRHSLPAMNGPSGLPVSKKRPSLASKQRGKRLSFN</sequence>
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            <fullName evidence="2">Chromosome 4, complete genome</fullName>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328865.1">
        <property type="nucleotide sequence ID" value="XM_011330563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S9E5"/>
    <dbReference type="EnsemblFungi" id="CEF85501">
        <property type="protein sequence ID" value="CEF85501"/>
        <property type="gene ID" value="FGRRES_13476"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13476"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G28285"/>
    <dbReference type="eggNOG" id="ENOG502SIP1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037030_2_1_1"/>
    <dbReference type="InParanoid" id="I1S9E5"/>
    <dbReference type="OrthoDB" id="5131365at2759"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF85501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="239" mass="27646" checksum="4763A9DE1A46FC62" modified="2012-06-13" version="1">MGLRYSDRQNVLASCNQVSRNVFPCVVFVFSLFYPSRLHPPFKRPKVAAMEDDSQPFDPTQWDYDDLDFCTPQLRGTNTCGVSLADPSPSPSSHQRSRLPLLQLDDWDPDDTYDECPPTSVHYSIEWKLQLRKGRLSKLTNDTEQNLVLAPGALWETTLKDKVDRLLRQKTPRGKSYLPEETIVVVSVTDRSERDLTKRFDEFDIDWQMAAEQLCKWSPLFRAGKKLRIDISFICKEEP</sequence>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I1S9R2</accession>
    <name>I1S9R2_GIBZE</name>
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        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Nectriaceae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328257.1">
        <property type="nucleotide sequence ID" value="XM_011329955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S9R2"/>
    <dbReference type="EnsemblFungi" id="CEF85554">
        <property type="protein sequence ID" value="CEF85554"/>
        <property type="gene ID" value="FGRRES_13593"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13593"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27013"/>
    <dbReference type="HOGENOM" id="CLU_1885951_0_0_1"/>
    <dbReference type="InParanoid" id="I1S9R2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF85554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="135" mass="15388" checksum="593B6A7CF24009E1" modified="2012-06-13" version="1">MACNIIWLSEPLFNQPSDDILTLKDDADPRLQTRHFTVSQISVPNTLPETFLDSYSPHHENTEDDDMNKASSLFLFGTDGGHDVGLALEPPRLLPVVNLLNSINWKHIDEITEEALPGPQGIRKIDCWKHKRRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1S9S4</accession>
    <accession>A0A098DQQ3</accession>
    <name>I1S9S4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T26805</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328158.1">
        <property type="nucleotide sequence ID" value="XM_011329856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S9S4"/>
    <dbReference type="FunCoup" id="I1S9S4">
        <property type="interactions" value="731"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1S9S4"/>
    <dbReference type="EnsemblFungi" id="CEF83689">
        <property type="protein sequence ID" value="CEF83689"/>
        <property type="gene ID" value="FGRRES_13605"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13605"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26805"/>
    <dbReference type="eggNOG" id="KOG0704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044516_2_0_1"/>
    <dbReference type="InParanoid" id="I1S9S4"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:actin filament organization"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
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    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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    </dbReference>
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    <dbReference type="EnsemblFungi" id="CEF75641">
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        <property type="gene ID" value="FGRRES_13727"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="CEF75641.1"/>
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    </evidence>
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        <source>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
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                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325358.1">
        <property type="nucleotide sequence ID" value="XM_011327056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1SAJ3"/>
    <dbReference type="STRING" id="229533.I1SAJ3"/>
    <dbReference type="EnsemblFungi" id="CEF87369">
        <property type="protein sequence ID" value="CEF87369"/>
        <property type="gene ID" value="FGRRES_13874"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13874"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21007"/>
    <dbReference type="eggNOG" id="ENOG502SNM0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003953_2_2_1"/>
    <dbReference type="InParanoid" id="I1SAJ3"/>
    <dbReference type="OrthoDB" id="5135333at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="83"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF87369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="642" mass="73940" checksum="0585A6973032B20C" modified="2012-06-13" version="1">MPAPRDPGYPRFRHDHKPLKPPTPPAPRWIDLNTISSWIRACNENHGDHCQRARLPHETQGLPRWLIHVSEKRIVPFQPGCRYVALSYVWGRSTGHDLQLLLSNLELFQQMNALEQMWDQVPATIQHAVELIQRVGEEYIWVDRLCIVQDDYETKQEQISQMAFIYGNAYFTIVATAAHSAEEGLKGIKDVSPSMYHNVWPERANMDHYGLVAWSPWNERGWTLQELVFSQRSLFFHKNELTWECHCAIWHERMQLADIGETSCLGTHNPNARGFRYSPWPDLQEFHQLATSYSRRQLSFSSDILPAFAGITTALAHSFPGGFLFGLPEVAFDVTLLWRSAGPASRNSKLGEASVPSWSWMVCLDQKISVDLSPWASGFAYLAGSSSEQSDEGGRRTYTPLHVAYQQEWNSRWSRKRPPAGVLDGLVTESICSWYVKEEAGERLISNDLDEFKDCSHHQSNELPMGWKRDGDLFYHLVDPQRRFKYPIPLVTNEDDIFIEKYLSFLIKTRTERAFFYNTPEPYGQAVSMLEGEAVVNICNNEQVWVGCLRVQTRTILWRLLTKKVECELVAISKGYIDSSAGGWSRLDEHEALKSRELERYEFYNVLFIEWKDGVAYRQGIGRVDKTAWEGESRQVIDLVLG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q4I0M9</accession>
    <accession>A0A0E0SCF8</accession>
    <accession>V6RV03</accession>
    <name>PTPA1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName>Serine/threonine-protein phosphatase 2A activator 1</fullName>
            <ecNumber>5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Peptidyl-prolyl cis-trans isomerase PTPA-1</fullName>
            <shortName>PPIase PTPA-1</shortName>
            <shortName>Rotamase PTPA-1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Phosphotyrosyl phosphatase activator 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RRD1</name>
        <name type="ORF">FGRRES_09229</name>
        <name type="ORF">FGSG_09229</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8"/>
    <dbReference type="EMBL" id="DS231668">
        <property type="protein sequence ID" value="ESU15770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328546.1">
        <property type="nucleotide sequence ID" value="XM_011330244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4I0M9"/>
    <dbReference type="SMR" id="Q4I0M9"/>
    <dbReference type="FunCoup" id="Q4I0M9">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="229533.Q4I0M9"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T27617">
        <property type="protein sequence ID" value="FGRAMPH1_01T27617-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G27617"/>
    </dbReference>
    <dbReference type="GeneID" id="23556192"/>
    <dbReference type="KEGG" id="fgr:FGSG_09229"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27617"/>
    <dbReference type="eggNOG" id="KOG2867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030733_2_0_1"/>
    <dbReference type="InParanoid" id="Q4I0M9"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0697">Rotamase</keyword>
    <feature type="chain" id="PRO_0000226100" description="Serine/threonine-protein phosphatase 2A activator 1">
        <location>
            <begin position="1"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="445" mass="48544" checksum="35CD37610D5CAB68" modified="2005-08-16" version="1">MTSTTPPKLNALEILDLRSSPPAFTTPSKRINEGSDVARFLTSLAYRDIGVFILQLNRALCPRNQSSSPLPRTFPLNSKPATTPSVQTLQALLAKIGSFIDEAPPDPGPRRFGNVSFRKWHAIFEERLSELLDEGLLGETLKVGDGKAKEEVSLYLLGGFGSVQRLDYGTGHELSFVAFLGCLWKLGFFKDGEQGGEIEREIVLKIIEPYLNVVRKLILTYTLEPAGSHGVWGLDDHSFMPYIFGSAQLTRPINENEPMPLEGSVKGAPKPSDVTKAVVVEDQRQVNMYFSAIGFINDVKKGPFWEHSPILFDISGIRDGWGKINKGMIKMFNAEVLSKFPVVQHFPFGSLFSWDVDPDATTPTQSVHMVNQPAMAAPTPSGPGTSAPWAQATRMPPSGPGIPYSRMPPPGPNSGSLARPPRNTSGTGSTDAQITVTKAPWARDS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q4IFH8</accession>
    <accession>A0A098DJ41</accession>
    <accession>A0A0E0S624</accession>
    <accession>A0A1C3YN08</accession>
    <accession>V6RB63</accession>
    <name>HIR3_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName>Histone transcription regulator 3 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HIR3</name>
        <name type="ORF">FGRAMPH1_01T14293</name>
        <name type="ORF">FGRRES_04030_M</name>
        <name type="ORF">FGSG_04030</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HIR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS231664">
        <property type="protein sequence ID" value="ESU09125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321624.1">
        <property type="nucleotide sequence ID" value="XM_011323322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4IFH8"/>
    <dbReference type="SMR" id="Q4IFH8"/>
    <dbReference type="STRING" id="229533.Q4IFH8"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T14293">
        <property type="protein sequence ID" value="FGRAMPH1_01T14293-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G14293"/>
    </dbReference>
    <dbReference type="GeneID" id="23551300"/>
    <dbReference type="KEGG" id="fgr:FGSG_04030"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14293"/>
    <dbReference type="eggNOG" id="ENOG502QQX4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001419_0_0_1"/>
    <dbReference type="InParanoid" id="Q4IFH8"/>
    <dbReference type="OrthoDB" id="77564at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000256201" description="Histone transcription regulator 3 homolog">
        <location>
            <begin position="1"/>
            <end position="2020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="791"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1757"/>
            <end position="2020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="809"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="823"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1757"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1791"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1815"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1847"/>
            <end position="1864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1865"/>
            <end position="1897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1898"/>
            <end position="1908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1915"/>
            <end position="1934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1950"/>
            <end position="2001"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="2020" mass="226951" checksum="DB1198CAB148C5E5" modified="2005-08-16" version="1">MPAFQAINLEPEDNIDEQIDTTKEIHVDEALKRFQHALKLHAQGPRSREAAEAAYNELFESEIFKYREAKTDYERAERYADGQPEVSNLDPSLTDGGLDVDAGGADGVAASLAQALYLSYKNYGQFFVDKFKDASTSDTAWKEKAQLKYHDDGRKVLDSWMTALDQDPSDPELWRKAARFAGAINSNRIKRYCLEAAIELDDDPAVMELDPPSLAEGMAGEQLKDQLKLLGDDMALSHPIMAPWLKKKMPALLKRHLDPIPFLPDPTKSLIPPKVSDTQAQTQEDTEMGDADNASLTEPKSVSSWAELGAKLINCLETTAEAFDTCDGIVESSLEDVPIETPPNEIESVASEIEVAVTKPTETEKSPEKDSTPKEQKAGSEGTEDSQKTADQSQKDSNGASARKRSQSAAGLPDGAEEENAMEKRSKRVRRRETLQAEETTDPNTLIANQLQPYQGADQNLFQMTKSVLEHLGVEDKSTFAFITELIDSCATENRPGKITNLAACDLSSVIVNFREEVAKVFLHKNEQASLGPSSFLEHAKTGSQDQPSMPSFNEKQGLRSFARKIGGCRSWMTAEDVAYEWVRAVSQSYATAKWSDKMKLSVVQMLNKVDSTLYRKITEEMELAAGSAERLADLETIVPMLFELHVDIYELITNPSSVVDYATRMDTKYRLGRWLDIASAYLRLIDRPANDPLIARFLWASVLVSSHAEQPLREHILLMWTSLRDHLADEKVPAISLPNNVVMPTISPAAADREISKLTTMDFFLGLFQDNMDDPVFVIDTLEPVLNPSTVCAPNQGTDSESGEDSDSSASSDTTGASTLDSSDDSTDDNDESSDASSNQKQKKSISDCASQSLKDLWKFLHNSSTELRLFLWSRLGDAYDAINYSTKKFSCCLKSIELIVSDLEGETYANTVPESRRLLFMRTLKSLDELLITALGSALNDNTAFEIIDDAHIRSTSAALAKVNCLLHVASLCEDEVRIGIKPERTGNAASKAAFQALKNKLKEMQIRAWCLQYTMFKAGINKDNCIIGPENDLADYLAAIHQVIGIRKFCKASNKIFLKVMRVELLKLKNIENWEDYLGQVLYDLHGLKLGAGVWEVQDHACPPEKLEKRQTMQLVERVCILANRMPMKDLLKSDLKTTIDHMQQTIGQTKSTPQMYHNLRNFTEYLKKPIHPLRLYRALIGDVSVDAVSVNTPETILATHGWFFLLGMMALTKFKGVELNRRQTPGATDDLRIGATFLRLQLQFTADRWDAWFRLAECFDYELDEAVLWTADKMNKERPELVKFQRNAIHCYTLALSHSRNLDIETHDGDPLHDLYHKFAMRMYASSREPFAMEPFQHSDQERYFIEDMGIGTFKRILHSQMNKYKVWKFAAKLFRMAMDRKPDNWKNPYMLSKCYWKMYQTPDDQLDVKDITSKIGLMTLIDTLKKAVEVAHNARRGRNTDPIFEPHYKIVTILHKLVIRGDVPAKDAAEILSEQPFGLEVNPDDHFASFSALEDWEEYIIRNLSKLKEKDKANWQHRIIIRHAKILFDEATEVSSEDRLVNAKAAFGVLRDSMFTKTMVMNVWKCDAERPGRHHVYTEQYVRLMTKLLVIMNDRGNLEQLLRRLRKKGADFYHFTDLWQSCCMAYLKLLRQGYNVSPVADDAFKALSSEEFEVVGERIADWAASDGAENPLFNCMKEAIEFKKLNANLMKVAPIDDLLYDCYSRIYSEIAKTLPGPDPSKVVEERHHAKEVAAQLEAAQTETKVTSSLASILNAPNGQESITGTATPMETEKQEAAPRSRKTGVRRPDVLRKAEQAVIRALEAPKPNKSRVGSVSSGKRGSRTPNQRASDAGSEEDGPDSQIRREAGHDGDVDMKDAGDENEEDHGEEEHDEENEDEQDEEHDEAAEDENAEEHGVEEKADSETGSIEDSADDESDLSDVPEDYDEEVPPGLRFSNLGHQSEESSGEDADSESEGDDEAEESDGEEEAEEEAEGEETLGIEDTELADEDEDEDEEQPKRSGSWAANDSIRAVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D5Z7</accession>
    <accession>A0A0E0RQ36</accession>
    <name>A0A098D5Z7_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG01259.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T03119</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
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    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A098D5Z7"/>
    <dbReference type="EnsemblFungi" id="CEF73361">
        <property type="protein sequence ID" value="CEF73361"/>
        <property type="gene ID" value="FGRRES_15837"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03119"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098D5Z7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="214"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="684"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="438"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF73361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="706" mass="82539" checksum="D504E016BF9D9EFB" modified="2015-01-07" version="1">MPGAFGPEDYIDFYENPLEVLDNLESAWKNREPRITWSTNNLPTLDDVDFDWRTYNPPGALRRAPNITSQVLLDILQSSVQNVEERNIEEDRQKKEADAQRQLQENEKGKNKEPYLPIIIPIEKLVQDDTSKDVPKIKPDILMTTFGPSVTVTKNGAKANKKRLVALRRFFQRSEEKGESSATGAVLMALREEAGETEPGSENLVRLTKPDTIEEVECVSCLDDFHPKDVIKVPCHSYCHDCFIRLVSAACQNEQQWPPKCCLNEVPVKIVLRFIPSNLKKTFEERSKEWELPVSERVYCSEPNCSLWIKPKRIDLSRRRGVCDRSHRTCTLCRGPAHQGEECPQDVDMTLTNQLAEEEGWKRCSKCHALVEHREACQHMTCRCGNQFCYVCERRWRTCDCTMEHLQAVKDGAAARREERRVNELAEAEEIRQALLQIEEFEREEALKAELLRQEQERLEEERRQRELEERARQESIRRRDIEIKYHELRISLDQLHELQQVLLEIDQETEGEDMVIGIESAKDSLEKKHESERSELKITISKKMAEKEDALNKDFQIRAAQENDLEQAYHERLKAYWKDRKDGDEEIENAMLDLRKRMDQKQYAWQKWKAEQLKDLEVKLQDNETYREELMYSAKHRLDDSCKEKEREMVRRMAAENKWLEAVVLEREKLLSEWEYDEVEGDADSIFAPESDGSGDGNYIVGTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D6I5</accession>
    <accession>A0A0E0RQN6</accession>
    <name>A0A098D6I5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T03511</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D6I5"/>
    <dbReference type="STRING" id="229533.A0A098D6I5"/>
    <dbReference type="EnsemblFungi" id="CEF73561">
        <property type="protein sequence ID" value="CEF73561"/>
        <property type="gene ID" value="FGRRES_15850"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03511"/>
    <dbReference type="eggNOG" id="ENOG502RI4A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098D6I5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF73561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="254" mass="29347" checksum="9755E3B640D63CBE" modified="2015-01-07" version="1">MRLNSKPPKIDFGPLREKFLGVVAKPWTLWRIEYEDQAKLSLSQVKHTMQLETQKQPIPRKVVILDCEYGFGLKLLEFSIVDRETNEVLINTLIRQTDVEADLRLKQFPPSVQNADKLRKEKIFANANTLTLMDVNQVAKALRRHNMKEFGMERKLSNVFELLYPGHDLIGHNHRALPDCQQTMLVLDAFDEFCKPNEERKSEWKLETLVERFSAVAVQATSVSAKRRRASSTEREDAEGPSGPKRTRLSSKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DBN1</accession>
    <accession>A0A0E0RX85</accession>
    <name>A0A098DBN1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG10441.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T08113</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DBN1"/>
    <dbReference type="EnsemblFungi" id="CEF75860">
        <property type="protein sequence ID" value="CEF75860"/>
        <property type="gene ID" value="FGRRES_10441_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08113"/>
    <dbReference type="InParanoid" id="A0A098DBN1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF75860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="140" mass="15360" checksum="1ADB73A83C563182" modified="2015-01-07" version="1">MSSHITADVSSLEDAAPSNTMLAWLAAILFPLMALTIITSRLLSSAEESQRLMVSKSVSMGEANLFCILGGIIAYHSVIKRFTVSGLAAPRLPCSSKNQQSHEVKHHEPCSRLVGYARLEHDMTLVDWKGHSPSMYMMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DCQ7</accession>
    <accession>A0A0E0RZQ3</accession>
    <name>A0A098DCQ7_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG08396.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T09851</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate</text>
            <dbReference type="Rhea" id="RHEA:22936"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="3.5.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="2"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DCQ7"/>
    <dbReference type="STRING" id="229533.A0A098DCQ7"/>
    <dbReference type="EnsemblFungi" id="CEF76728">
        <property type="protein sequence ID" value="CEF76728"/>
        <property type="gene ID" value="FGRRES_17044"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09851"/>
    <dbReference type="eggNOG" id="KOG3892">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DCQ7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000065">
        <property type="entry name" value="N-acetylglucosamine-6-phosphate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="11">
        <location>
            <begin position="66"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="253"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="348"/>
            <end position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF76728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="444" mass="47751" checksum="919C8B6A5D003936" modified="2015-01-07" version="1">MPIAVSPTLPKNGLTKFTNCRLLKGNDLVWDDLWVSSVNGKIVDSQASFYGGRNMPDNTIDLGGRIIAPGFIECQLNGAFGFNFSTLLDNMAEYGKNIQKVNRLLVRTGVTSYIPTITSQRPELYQKTLPYLGPSGELRIPGHGAESLGAHCEGPFLSPTKNGVHNVDVLTEAHSIEDIERCYGRENMVPRPDGSPIPIKMITAAPERGQMMNLIPEITSRDIIYSVGHTEATYEETSQAVGKGATMITHLFNAMRPLHHRNPGVFGVLGKAESLPRPYFGIISDGIHLHPTTIKIAYSAHPDGFILVTDAMHLVGLPDGAYPWTNGENTSNIVKRGSKLLLENSDTIAGSSITLLECVNNFMKWTGASIPQALGAVTSTPAAMLGLQGVKGTLESGADADLVILSDGYGGQDEVGGSSEVLVLDEVWKFGESVFASATESKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DCV8</accession>
    <accession>A0A0E0RYF2</accession>
    <name>A0A098DCV8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG08027.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T08949</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DCV8"/>
    <dbReference type="STRING" id="229533.A0A098DCV8"/>
    <dbReference type="EnsemblFungi" id="CEF76277">
        <property type="protein sequence ID" value="CEF76277"/>
        <property type="gene ID" value="FGRRES_08027_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08949"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DCV8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="670"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="50"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF76277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="864" mass="96405" checksum="1017494544C81FC5" modified="2015-01-07" version="1">MPDNYLSDTSDAKTVQDSASKRLTVTLEDVGIQVSGEGENFASTCISVITGIFQLGRKKSPKRQILQGITGQVCPGQMLANQDILQLLVVGRPGSGCTSLLKVISNHRSEFNEVQGLLQYGNVGHDTAKEFRHHIVMNTEDDVHFPTLKVAETMSFANSTKVPKTRPQHLTTKAYVHQTSTGILESLGIGHVHDTIVGNEYVRGVSGGERKRVSVAEVMSTQAPVQCWDNSTRGLDASNALDFARVLRKHADEQQRTIIATLYQAGNSIYDQFDKVLVLAEGREIYYGPSTEARHYFETMGFRCPPGANIADFLTSVTVETEREIIPGYETTVPRTAHDFEQRYKASETFHRMKHLAKSRTNESLAAEVDGLRDTVSKEKSRTVAALSRATSPYLDSFFQQVWICAIRQFQILWGDRFSNGLQLASSLIMALVTGSLMYNLPEDSTSIFRKPGALFYPILLWGLNKMAETAASFEGRAILTRHKRLAFNRPGAYALASVLTDIPFVIFMFSLFNLIYYFMVGYQHDAGKFFTNWFIYLVTTLCFTSLYRTIGAWCKHFGLAAQISGWITMVMMVYAGYLIPTTKMHPWFRWIAYINPANYAFSAVMASEMGDLQLACVEPQLVPYGSGYDDNRFRSCTVVGSNGETIDGASYLSLQYGIARTEIWRDVGIIIAFWVFFSITAAIGFEMNLASGAGSMILYDRRSQAKELALKDDPERTSVQPLPEQNDYITAATTFTFKNINYFVQHEGQEKQLLQNVSGFVKPGQLVALIGSSGAGKTTLMDVLAQPKDSGRLEGSIMAYCRLHSITFLRTTTYGEHNNSYHSTATILEIIPSQHVVSFLVAPQLPCRRRLPRSWDPTPLQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DE99</accession>
    <accession>A0A0E0RYE6</accession>
    <name>A0A098DE99_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG08024.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T08937</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DE99"/>
    <dbReference type="EnsemblFungi" id="CEF76271">
        <property type="protein sequence ID" value="CEF76271"/>
        <property type="gene ID" value="FGRRES_08024"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08937"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DE99"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF76271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="301" mass="31922" checksum="D78A5EC367CDE7F3" modified="2015-01-07" version="1">MSIDHAANDELKASSLFDVSHITAVVTGGATGIGLMITQALVSNGAKVYITGRRTEKLEQTKKIYSTGPGSIHVLPGDVSSKDEAIRLAKEVGEKEPNGIHLLVNNAGIARDDETRFSLAGEPNMTDAQAISDHFLRTKSEQWTETLTTNVAGPYYMSVAFLPLLAKGRDAIPGYTSQIVNVSSTSGAMKGSSWGQPVYATSKAALTHLSRILATLCKDVKVRVNVIAPGLFPSEMTTGESDEGNKSKIEKKSYNPAGRPGHDTDMAATILFLVGKGGLFYNGQIVYPDGGNLLVQPGVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2024-07-24" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DJI1</accession>
    <accession>A0A0E0S540</accession>
    <name>A0A098DJI1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG03751.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T13625</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DJI1"/>
    <dbReference type="EnsemblFungi" id="CEF78615">
        <property type="protein sequence ID" value="CEF78615"/>
        <property type="gene ID" value="FGRRES_03751_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13625"/>
    <dbReference type="eggNOG" id="ENOG502QRYG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DJI1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF4">
        <property type="entry name" value="HYPOTHETICAL AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF78615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="601" mass="66305" checksum="740889ADD0CFECC9" modified="2015-01-07" version="1">MSLAQHVTHPEGFDYEGPANPNYEGPIHPDISPGFGTPNILVPDRYEYESFPDRSSWRRLSFAPIEIAQKLPNLAAYKVSNFKRYAQVATAIIACWLASGIVFGFAALKPILISEGIYSELCDNDQKSLGHAPDFQVPCAAQDMRLNLLFISASISANVSSLFAGAALDRYGRRVCWLVSSLLLTLGSLMMGLSFSIPGFHGYLAGNILLAFGGTFLFVSSFQLANAFHTLSGLIVALITGAFDASAAVFLFYRMAYEASDGRFTLDKFFFGYISVPVFICVAELLWMPAHSYHTLPQLEKKLQKAVDRNRDIHASDDEIEDTDELRRIRSVRADQRRAKIEKIEEVAGDSEEREMRIIEEEDRQETSGVWGVLHGVPAHRQMMSPWFILILLLTILQMLRMNYFIASVRSQYRYMLGSDEAAKRINDFFDNALPIAGVFAVPLVGALLNNLSIPCIFGVVTVCIAIIGVLNCLSNIWAGYVTVIVFVVFRPLYYSAISDYATKVFGFATFGRIYGTITCVSGITQLAQSGLDALTHGPLHGNPTPINATLGAVGALVGAIMTVFVAIKGNRFEEKKAEMKADDERERLLSNAQSNYGTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DM07</accession>
    <accession>A0A0E0S7P5</accession>
    <name>A0A098DM07_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T15437</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DM07"/>
    <dbReference type="EnsemblFungi" id="CEF79520">
        <property type="protein sequence ID" value="CEF79520"/>
        <property type="gene ID" value="FGRRES_20213"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15437"/>
    <dbReference type="InParanoid" id="A0A098DM07"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF79520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="37" mass="4409" checksum="8A21DD8ADB8DCE57" modified="2015-01-07" version="1">MSAPNQQKRKRNADDKTMEELNRYKNKPLERGSFLTI</sequence>
</entry>
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    <accession>A0A098DML0</accession>
    <accession>A0A0E0S875</accession>
    <name>A0A098DML0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG04652.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T15803</name>
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    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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            <taxon>Fusarium</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DML0"/>
    <dbReference type="EnsemblFungi" id="CEF79700">
        <property type="protein sequence ID" value="CEF79700"/>
        <property type="gene ID" value="FGRRES_04652_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15803"/>
    <dbReference type="InParanoid" id="A0A098DML0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010018713" evidence="2">
        <location>
            <begin position="22"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF79700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="136" mass="13623" checksum="26F7327F2B66B4BA" modified="2015-01-07" version="1">MIPKTLVLAFMASCFVSSSSASPCKASSASTETSLSTEVPTSTAIPTAIEATLAMTESESDIETSTASQDSATSTVSHEATPTSFTNTASATTQPTAPVFVDIDCSTDSDCVAALGPAALGIYGCVDLICQPTAAP</sequence>
</entry>
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    <name>A0A098DNL2_GIBZE</name>
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        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG09213.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T27649</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DNL2"/>
    <dbReference type="STRING" id="229533.A0A098DNL2"/>
    <dbReference type="EnsemblFungi" id="CEF83450">
        <property type="protein sequence ID" value="CEF83450"/>
        <property type="gene ID" value="FGRRES_09213_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27649"/>
    <dbReference type="InParanoid" id="A0A098DNL2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF83450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="393" mass="46041" checksum="A6513A39739B3EC2" modified="2015-01-07" version="1">MYSFHITHQDDEAGSAGRSMIRPTPIYYQRQTGLNADDKLALDGVFAMLQPTPIYHRQQATAESDDEPDLEDSTLLRPTHQSQICQIPVDRLALARGMLKPTPIHHWEQETSDSEDESDFDEEVTLLQPTPIYHREQVTSDSDGEFDFEDFPMRFSDDGVYSVTPTFWHYRDEMAVRRRVERTMELSVDMYSPTIEGRNCDWALIFHDPFFGKAFRFRMAGGPRIGEPWRFDFECGWPNPFPTPAKRYFITTMPERQCHRIHAAARRTHGRFCQQWVVDALRDLESQSLVPPGKASELYQFLEMDQYPDVQPSYNDQLTRIEQERALPLSERMLLWTFGQRHREVSIFGRLHGRFVEGMLRLGLDLEVQILINHRSDQTEAMWVKWRTILFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DQ47</accession>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the engrailed homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A098DQ47"/>
    <dbReference type="STRING" id="229533.A0A098DQ47"/>
    <dbReference type="EnsemblFungi" id="CEF83479">
        <property type="protein sequence ID" value="CEF83479"/>
        <property type="gene ID" value="FGRRES_16777"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23953"/>
    <dbReference type="eggNOG" id="ENOG502SCMP">
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    <dbReference type="Proteomes" id="UP000070720">
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    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Engrailed_Homeobox_TFs"/>
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        <property type="entry name" value="Homeobox_CS"/>
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        <property type="entry name" value="Homeodomain-like_sf"/>
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    <dbReference type="PANTHER" id="PTHR24341">
        <property type="entry name" value="HOMEOBOX PROTEIN ENGRAILED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341:SF6">
        <property type="entry name" value="HOMEOBOX PROTEIN INVECTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="57"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="59"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="124"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="261"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="495"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF83479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="525" mass="57890" checksum="BD6AB6F9DC19D7AD" modified="2015-01-07" version="1">MGSYHHQPQWPGWAYQNHTSQYPRYSQQLPSYAAYLPESMELYNAHQGHLLHRHQMSRTTETKPRLSKEEVEVLEAEFQKNHKPNSTVKKALAESMRVDNARINNWFQNRRAREKKEKNIREYAAKQRLDKDTATNEAGVHSDDDRLSDRVVSSAPFPAPRLVGARTTNISSPEQESENDTSQPDFGAGSSPDLSSQPTPEPLSASTSTSLACYSQYPQLIVPEDEDEVTPSLPQQCFPRLSTSPIQEQYMYSRNGVAVSQSNQPSMLKPSPSMDIASRRNKRPPQLAINAPRSFSASGPRTGIDIGRRAEVGHSMRRVASATGVGRVGKPMTGPRSPYFERNPDALLQLNRSPNFQKAATIAPPTPNTPVVAHQQGLCEATPASTVGYEEKYPMDLAIHDPTLRTPPTTPGVMDHLYNNDSNYQVAIADEPLVTPGLVAFPHDFEVPGSSGQVPNYLSHGCASQPQTPSYAAPMGPTYFGFAGGNAEYNWSDDASLSAHSSPGQSQQNVNFMNMTPSSFTYSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DU48</accession>
    <accession>A0A0E0SD35</accession>
    <name>A0A098DU48_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T23955</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DU48"/>
    <dbReference type="EnsemblFungi" id="CEF84348">
        <property type="protein sequence ID" value="CEF84348"/>
        <property type="gene ID" value="FGRRES_20354"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23955"/>
    <dbReference type="InParanoid" id="A0A098DU48"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF84348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="77" mass="8410" checksum="EC6CC9D07D0BB54E" modified="2015-01-07" version="1">MSRCCALARYLEQLWVQVPNLGQRGVPGSRETSEGYRTVDREYGQGAATTAAQAGAERSLLCNTLRDPGARLKRNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DWA9</accession>
    <accession>A0A0E0SGS9</accession>
    <name>A0A098DWA9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T24287</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DWA9"/>
    <dbReference type="EnsemblFungi" id="CEF85642">
        <property type="protein sequence ID" value="CEF85642"/>
        <property type="gene ID" value="FGRRES_20359"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24287"/>
    <dbReference type="InParanoid" id="A0A098DWA9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF85642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="131" mass="15188" checksum="7913B774A0CA35FE" modified="2015-01-07" version="1">MLLDESYERFGSIAMRKEWWFWQRKTQCYRLVIRRCPRVRLDAEAMRKLDNVPGLVDLLMVTFPLMSGVSEYSTASGDCSPKSFGGEQDTVESLDDTVDLLGRYTQVMPFLRQCQMKICSDTLALWTVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098E4G2</accession>
    <accession>A0A0E0SPY6</accession>
    <name>A0A098E4G2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG06218.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T19787</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098E4G2"/>
    <dbReference type="EnsemblFungi" id="CEF88499">
        <property type="protein sequence ID" value="CEF88499"/>
        <property type="gene ID" value="FGRRES_16619"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19787"/>
    <dbReference type="InParanoid" id="A0A098E4G2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF88499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="253" mass="28811" checksum="3492EBF7387BC78B" modified="2015-01-07" version="1">MFTLDVYGTPFSAIVILTESMMRQNSLQSIETTVSDAIDSDDELSGMLWHMTTDRERSYSSSPETPRKRNGQEGSLESTLTDNEKDQCIQVQLPLKLERRLKIQRTESIRSDEDTQSVRSVSVNTDVEDDELSHERPSPKPPSQPFETVITTKLRPVPKGAPRTIERKGQYTIRKGVRIQDYRLPGPNPWPRASPSNSLEYQCRDGFNEKEASLGYPQPMVAWKRRAMCKEAVWEHDRPHLQISPSLGALNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098E4M0</accession>
    <accession>A0A0E0SNU0</accession>
    <name>A0A098E4M0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG11168.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T21385</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098E4M0"/>
    <dbReference type="STRING" id="229533.A0A098E4M0"/>
    <dbReference type="EnsemblFungi" id="CEF88103">
        <property type="protein sequence ID" value="CEF88103"/>
        <property type="gene ID" value="FGRRES_17463"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21385"/>
    <dbReference type="eggNOG" id="ENOG502QTZI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098E4M0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040771">
        <property type="entry name" value="TLP1_add_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF139">
        <property type="entry name" value="THIOLASE-LIKE PROTEIN TYPE 1 ADDITIONAL C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18313">
        <property type="entry name" value="TLP1_add_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase-like protein type 1 additional C-terminal" evidence="4">
        <location>
            <begin position="426"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF88103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="512" mass="55373" checksum="E8A5B95EDB68BECE" modified="2015-01-07" version="1">MAALPSLTPVIIGIGESRQKDFTIETCREPAELILSAIRDASKDSSINAVEKLDSISVVPPWSWNYDDLPKLLAQRLGIQPSHLELASHGGNTPALLCDKAAARVASGDVKMAVVTGGEALASLFACQKAGKIPPPGWTEMSPDAKRYSPGDTSLKKGAGATHSIGNPIQVYPLYENAYRKQNQQSYIENHHESAELYTQFDKIACQHPNSWRAEETPRTLEDIKTVSKRNRMICTPYPLLMNAFNGVNLAAACIITSTEYATKLGVPREKWVYVTGGAGSNDSSDFWERSNYYSSPAIEYSIDNALKAAGLKKDEIDCFDFYSCFPIVPKIACKHVGLDLLNPKKPITLLGGLTSFGGAGNNYSLHAIAEMVRVIRKGKYQNGLVLANGGVLSWQHAICLSAKPKRNGSAYEAPAVLDNGQTSQGPTFTAQAQGEAIIETYTVDHDRSGPKLGHIIGRLVETGDRFIANHGDEMTLSALVSTSSELIGMKGFVEVGPDGRNVFTVDPSVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098E4U5</accession>
    <accession>A0A0E0SP75</accession>
    <name>A0A098E4U5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T19223</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098E4U5"/>
    <dbReference type="EnsemblFungi" id="CEF88238">
        <property type="protein sequence ID" value="CEF88238"/>
        <property type="gene ID" value="FGRRES_20282"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19223"/>
    <dbReference type="InParanoid" id="A0A098E4U5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF88238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="80" mass="9216" checksum="ACB32264B4AEF4B3" modified="2015-01-07" version="1">MDAPNSTTRTLPSKELEKLSLREMAEACELDFAQKTIEMWLWKVFRETNLAASTRLTDSMSPVKFITTVETSKKRIDSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RP23</accession>
    <name>A0A0E0RP23_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG00950.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T02393</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RP23"/>
    <dbReference type="FunCoup" id="A0A0E0RP23">
        <property type="interactions" value="588"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A0E0RP23"/>
    <dbReference type="EnsemblFungi" id="CEF72998">
        <property type="protein sequence ID" value="CEF72998"/>
        <property type="gene ID" value="FGRRES_00950_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02393"/>
    <dbReference type="eggNOG" id="KOG0810">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0RP23"/>
    <dbReference type="PHI-base" id="PHI:2395"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000008">
        <property type="entry name" value="Syntaxin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
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    <accession>A0A0E0SN29</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SN29"/>
    <dbReference type="EnsemblFungi" id="CEF87842">
        <property type="protein sequence ID" value="CEF87842"/>
        <property type="gene ID" value="FGRRES_20271"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18541"/>
    <dbReference type="InParanoid" id="A0A0E0SN29"/>
    <dbReference type="Proteomes" id="UP000070720">
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF87842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="53" mass="6253" checksum="F99D20FEB55C93AA" modified="2016-04-13" version="1">MPPVDVYLQYQLRPLKSTHPLSSIMHFYLMPKCNLDQNIYPGNFLQSVQLIEM</sequence>
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    <accession>A0A0E0SND2</accession>
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            <fullName evidence="9">Chromosome 3, complete genome</fullName>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SND2"/>
    <dbReference type="EnsemblFungi" id="CEF87945">
        <property type="protein sequence ID" value="CEF87945"/>
        <property type="gene ID" value="FGRRES_16536"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18687"/>
    <dbReference type="InParanoid" id="A0A0E0SND2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="30"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="315"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF87945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="397" mass="44649" checksum="6E6F7EA304552CF5" modified="2016-04-13" version="1">MDTTPKESRQIDLWTSEFITFAAATIFIGLRLLSRRLTRIEFWWDDWFALCCYAVAIAWVVIIPIWIKEGLGLHIHDVHNGKTIPEILMKNALILYVAELFYATALFCAKASILSFYWRMFRVTNIKLPIQILAGSALIWIIIRTFMGIWHCVPVERFWNPTAGGDQGYCAIEDKKFFFGTILVHVILDICIIALPILQVQKLQLPIAQKIGISLMFVFGIVICVSAMVIIVASTQFDAKSENLTWNLTTIVVWASVEVNLVTVSTCLPTVRPACIFLFTCTNPRSTINSGSNSYGHSYGRSHGRSQTKNTIRLSTLPNNKDNDESSSTHQLADSDRERQSSDFESHAMDRYRGNVATVTGPAHGRDQSEEFEVGTPFGGIMVKNETTVMVSNARPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SQ72</accession>
    <name>A0A0E0SQ72_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FGRAMPH1_01T16295</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SQ72"/>
    <dbReference type="EnsemblFungi" id="CEF88585">
        <property type="protein sequence ID" value="CEF88585"/>
        <property type="gene ID" value="FGRRES_16414"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16295"/>
    <dbReference type="InParanoid" id="A0A0E0SQ72"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF88585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="725" mass="81939" checksum="3BB26E66507C94C3" modified="2016-04-13" version="1">MTPEEESQSESVKQNRKANNVEPAPKRRRVALACSACRIRKSRCNGARPRCDTCEKLGFECLYEQQETSANLLVPKDLFAALEAKVNLLEANVQKHDGRLLVVEESISKIGNGPIAHHPKSGDVVVNIDRMDESCTDQNNTDGMAVSFVDEQDCGFFGPSSNIALMRHIRKVIDLNRPQTGQPSSLTPASEFSVYEGGLVSSSTTLPQTSQDSSKTLGVNLLPPDEVMKRLISAYFTNTGLLFPFIHQQEFLDTYQRFQASGFRTDVRRTWLGLLNMILAMATCTSCWEDSGSEKHFEESDIFYRRAQELCQTQMFRGTTLEIVQFLLLTSQYLQGTHKSVHTWTIHGLAVKGAMSIGLHSRDIASKFTPLEQEIRKRTWFGCILLDRSLSMTFGRPCSIPEEYIRLDLPKPLASDETQQLSTAFYNASIQLYRIMGKIIVSLYGSNLGCDDHASDTSTMTYIIQFEQELTDWQNSLPHRLSLHSANEVAQADMHDSIIERFRIILTLRHLNVQLLLHRPMFIRSLGALHKDPKMPHRNAGSVNSMQASFDRVFVQAAESTIDIIYSVLTRPDHGRHLIGAWWFTLYYAFSAALAVFGGLLISLDLEDEFTSANRLDKGKKYLNKVSETLLRLSGHNVIVLRCSKFLQQLTRIVNAWDTRPHQEVNSESQYLESNPFGAGSFDLESDLLSTMPQWEGPALNLGDELELGHFFASDSQRWFERAQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YHD9</accession>
    <name>A0A1C3YHD9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T00667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YHD9"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00667"/>
    <dbReference type="InParanoid" id="A0A1C3YHD9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42336:SF1">
        <property type="entry name" value="ALKYL HYDROPEROXIDE REDUCTASE SUBUNIT C_ THIOL SPECIFIC ANTIOXIDANT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42336">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="255" mass="27526" checksum="E6DF4FB99B92817E" modified="2016-11-02" version="1">MLSSFTTKLALKKAGIPSDILSFPTEKREPNKLRKNPPNPSDSDADSSWSSWMSVRSLPLTVQPWLTPPPAAVSVGRVPGIGDKAPVDKTQKLRLGRRTLVVFLRCVGCASVSHASEQATKKWVDLLGGAWSVRVIVDEDRALYAAWGLGTSSMWYVLNPSTQVQSWKETGWLGEKVAGAIQGKTTPKPKPKTTVQAVGNEEEEEDEGPLTTMGNKWQEAGAFAVDGTGTVIWGGKAARADDVMELEDGARILLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YHP7</accession>
    <name>A0A1C3YHP7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T00705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YHP7"/>
    <dbReference type="STRING" id="229533.A0A1C3YHP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00705"/>
    <dbReference type="eggNOG" id="ENOG502S36A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YHP7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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        </location>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="698"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="789" mass="82743" checksum="FA7B1419C756B594" modified="2016-11-02" version="1">MPKDSHLLPAHSQELLAAARSGRLYKRPAPAEEEENDADAAPEKTEKKEEDTGARGFSVKVWKQLPRNLDNSGASHLAKRQKNTVTIASRTVEEKVQGPTVTRATIRRIDAAGNPYTEEVTLGEGQKVQGEIVSTRIEPAPAAGLEPLATTPVPNRRRPPPPKRKTKAGPGRGKKKIKNPLPEAGAPVVAPAGTTDGATPAVPVKPENPAEAAIKQEREDSANRDSSMVDADDDDDDEDGEDDEGDEAEDGDGTPAPADGQTGGENNKQQDHEMTDAAPTTTTEAAPAPAPAPVPAPAEPPVAVAVAPANEDTDIVMENDSSEPAQESAANLAPPALTPEESRVEGSPLKNVVMPSPTKEDTEQMLQESLNAPFADIDEKKEPQLTEENLKEASLEPPVNDNEPHASGVDEEHILKTAANAAFGIDQPPVVGPAAEPAESTVAEPPSTIVGEAPEAATDRDIPMLEPTDNEALLPPPPEEVGNIAASPPGSSGGQGHSAPGSEAKLPFDILSGEEALPSRPQLEQKDTGLTEDSIRPDDSASITAPVSDVPDIPTAPPSIVEPPAEPPAETTLQESAGEEAKSPTPPQPEVKEESIPPAVEEVTKGESPDVMASLMDKLDQEHADIEAIKEDLPTPPVPAPVEESVPEAPTEMDIEPTVEPVAEPIEEPAAESGPKPVAETEVKPSVEARVDARVEAPVEVPTEAPTEAAADVPPEPASIPSEAPQEPVDEPMVTEPMAAEEEKPSDPVLEAPSVEAPTVLEPMKTEAEKKEEEIKKEVDIASLEAPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YI05</accession>
    <name>A0A1C3YI05_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FGRAMPH1_01T02433</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Also catalyzes the cyclization of FAICAR to IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YI05"/>
    <dbReference type="FunCoup" id="A0A1C3YI05">
        <property type="interactions" value="1051"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YI05"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02433"/>
    <dbReference type="eggNOG" id="KOG2555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YI05"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.440:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="13">
        <location>
            <begin position="38"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SCB64152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="634" mass="69557" checksum="1D5C1C2D2777CC1F" modified="2016-11-02" version="1">MRRLFSTYSFFSSFSSSSSSFFRPFSFSSPKSFSLLASNMSSQQKIAIVSVYDKTGLLDLAKGLVQQNVRILASGGTSKMIRESGFPVEDVSAITKAPEMLAGRVKTLHPAVHAGILARDLASDEKDLADQNINKVDYVICNLYPFKDTVAKINVSIPEAVEEIDIGGVTLIRAAAKNHKRVTILSDPNDYAGFLKELEKGDVTESSRNRYALKAFEHTADYDAAISQFFRKEYAGNGDQYSALRYGANPHQKPAAAYVSEGNLPFKVLGGSPGYINLLDALNAWPLVKELHKALGKPAAASFKHVSPAGAAIGLPLTEEEKKVYFVHDIEGIDESSLAQAYARARGADRMSSFGDMIALSDVVDVPTARIISKEVSDGVIAPGYEEAALEILKKKKGGRYLVLQIDPEYNPPATETRTVYGINLQQHRNDVEITPKHFNTIITPKDTASLPESAARDLTIATITLKYTQSNSVCYAYNGQVVGLGAGQQSRIHCTRLAGDKADNWWMRFHERVLGIKWKKGTKRPDKSNAIDLLVSGQLPKDGPEREAFEGVFEEVPAAFTAEEREAWMKQLKNVCVSSDAFFPFIDNVFRVSQSGVKYVAAPGGSQNDSAVFDTAEKLGITFVEQNIRLFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YI13</accession>
    <name>A0A1C3YI13_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FGRAMPH1_01T02077</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YI13"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02077"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YI13"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="AGL277Wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF40">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="57"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SCB64129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="605" mass="67994" checksum="9B31AC5F907930A8" modified="2016-11-02" version="1">MAPNRGEDDIERLSRTTNEYPSSSMIEHARRPSEAYVNLHANVEAKIKNPLWGLPRARLLADVDDFCRKKDLDHYRPLIRKGALVAQDPTGYEDIEGDEKLNDEEVQALRDEILHKWRVPFVLYLTVATCSIGAAVQGWDQTGSNGANLEFPYAFGIGGDSIHDKLLVGLVNSAPYIGTALFGCWLSDPLNSLPIFAAENSPAPIRGAFVMSWQMWTAFGIFLGTCANVAVTKIGHNAWRYQLGSAFIPAVPLMCLIYLCPESPRWYMKKNRYGDAMKSLLRLRNHPVQAARDLYYIHAQLEVELEFIGQGNYAKRFIELFTIPRVRRATLASFVVMIAQQMCGINIIAFYSTSVFRDAGATDNEALLASMGFGLVNFVFAWPAIWTIDTFGRRSLLLFTFPQMAWTLLAAGLCTLIPGTGGLHMALVALFVYLFAAFYSPGEGPVPFTYSAEVFPLSHREVGMSWAVATCLFWAAVLSITFPLILARLHAIGAFAMYAGFNIIALVMIFLFLPETKQRTLEELDYIFAVPTRVFMRYQVTKVLPWWIRRWILFQREARLDPLYQFDTVGEPEDSHGSDYGYENDKAKVELKDTIGLTSGVQATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YI20</accession>
    <name>A0A1C3YI20_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FGRAMPH1_01T02695</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
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        <property type="protein sequence ID" value="SCB64178.1"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="entry name" value="F_ATPase_subunit_alpha"/>
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        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
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        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="68"/>
            <end position="134"/>
        </location>
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    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="191"/>
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        <source>
            <dbReference type="RuleBase" id="RU003551"/>
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            <dbReference type="Pfam" id="PF00006"/>
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            <dbReference type="Pfam" id="PF00306"/>
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            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="SCB64178.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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    </evidence>
    <sequence length="552" mass="59724" checksum="844C1E08936B97CE" modified="2016-11-02" version="1">MFRNALRQSTRAVGAVSAAGRVAALRNAAPASINAARFYASDAKATPTEVSSILEQRIRGVQEESNLAETGRVLSVGDGIARVHGMANVQAEELVEFASGVKGMCMNLEAGQVGVVLFGSDRLVKEGETVKRTGEIVDIPVGPEMLGRVVDALGNPIDGKGPINTKERRRAQLKAPGILPRKSVNEPVQTGLKSIDAMVPIGRGQRELIIGDRQTGKTAVGLDTILNQKRWNDGNDEKKKLFCIYVAVGQKRSTVAQFVKTLEENDAMKYSIVVAATASEAAPLQYLAPFTGASIGEWFRDNGKHSLVIFDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDKLGGGSMTALPVIETQGGDVSAYIPTNVISITDGQIFLEAELFYKGIRPAINVGLSVSRVGSAAQLKAMKQVAGSLKLFLAQYREVAAFAQFGSDLDAATKQTLNRGERLTELLKQKQYSPMAVTEMVPLIFAGVNGFLDTIPVNKILQWESDFLAHLKTNETELLATIDKEGAISKDTEAKLKDVVQSFVKSFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YIY6</accession>
    <name>A0A1C3YIY6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T06563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YIY6"/>
    <dbReference type="STRING" id="229533.A0A1C3YIY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06563"/>
    <dbReference type="eggNOG" id="ENOG502S1FV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YIY6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018843">
        <property type="entry name" value="Utp8_b-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10395">
        <property type="entry name" value="Utp8_b_propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Utp8 beta-propeller" evidence="1">
        <location>
            <begin position="33"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="903" mass="98805" checksum="45FA6576374729BB" modified="2016-11-02" version="1">MASEYRIHKPSVLATLPRPLDHTKGRTVAREVYGLRDGQKKKKRTEVVVGVDGETASIYDIPASSLITSYPIPPQESFTCAPYSVRIRRSGTNDVSRYTYISTRDSTGQKITLFKDVVSQDGKTTSTTIASPVLLDKDSSIQYLVCASSVSETANVGDVIAVSQNGEFVSLSSETLAIQWTSSKSTVQDTIPTQIESFEVDYITSGTLAEFREGIFKDKPDVFSALPKTPNSEPELVALVLRTLSQGQERPHSVVLAVSSGAPSTTLDIQKLSPLEIAPIGTPSPRGTDKSTYEVDVQAALLMRLREGSLSIYDLTTPVPKLKSVVQTENAISFARLSRPFVLSCSSESISLYNHQYRSIHASAPLDLSEVFSEGEKPQSCQFISYLRSQELMVALVDNALVSIQIEPPKTHGKRRKQGLLIDSIGRGTATEIPAKKAKTDKLAAEFSKYVPGSMTDKYMTKLRKELEMADEHLSKGDLGEWEQLLRSRFHVGLRSVADGKEDKDSLELPEWEWLTGGSSYAVVDRRWVLYAIGRTFSLSMSEAPESRLKLQLILPDTNVTSYLVVAGHLTLSNLKAAFRDELDVEALDNKALVEDLLASLADADPSTTLMLNYLQATPLGELELLLAIRALMVSLDLIIDSKKPASSKLLTNEAHDGAENYDMDLDDLERDIAITEYYLGDDSSSRSRGLTLAFAKLWRLPALTTIKAMRTTLKTHDILSLIHTLRVELVRGAWTSLYLDSSSFDLDGSDPPPDGVIALISDLLGRCIDAVGAGGWLFNDNISGDNSDAGDLLTSLHNEVGVALEGIEEVVTINGYLREAVRYGQAAQKGGVGRPKWNTSKPVSMQLEGLESRLLPLGLKTKQLPTKSKVVSGGEVVQRSTRETGHLISQKVEAYSLEKLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKM3</accession>
    <name>A0A1C3YKM3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T22735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKM3"/>
    <dbReference type="STRING" id="229533.A0A1C3YKM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22735"/>
    <dbReference type="eggNOG" id="ENOG502QV54">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YKM3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000023">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="777"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB65084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="874" mass="94615" checksum="7835D0D20CA374FE" modified="2016-11-02" version="1">MNNSTEMAGSPAQRRWMPSVESYYDEIPAHGRGQTKSNDKHSAGISTPLFRERYYSTPQKQRSSWFFIVIMGLSTIVTASILAMRLFTLPASAAPQAAIPVPATPEYSAPVTPEYSVPAAPEYSAPVAPAAAGSWWMSSIKRQGAVAYGNSANYKIFRNVKDYGAKGDGSSDDTAAINAAFSDGSRCGKGCDSTTVTPALVYFPPGTYVVSKPILPYYYTHMIGDVNDLPVLKPAANFEGMAVIDVDPYNNDGSNWHTNQNNFFRQVRNFKIDLTGMPKSSGTGIHWQVAQATSLQNIVFQMIEDPSEDNKQQGIFIDNGSGGFMTDLTFIGGRYGGFFGSQQFTSRNMTFRNCQTAVYMNWNWLWTLNGLDISGSKVAIDMTAGGGVQNVGSILLTDSKIANTQVGILSNYDPAQPGTNGTLIIDNVDMSSVPVAVQNGGTSATILAGNTKIASWVQGRAYTGGNGEAVQATQTPIEKPKAILDSNGNVVTKSKPQYNSVPASSFVSVKSKGAKGDGKTDDTAAIQAVFDGVQEGQIVYFDHGAYVMTDTVKVPKNIKIVGEIWPLIMAGGDKNFKDQANPKPVWQVGESGDVGNVEIQDLMFETLGPQPGAILMEFNVAGETPGSAGLFDVHFRLGGSAGTQLQSDTCKKTPNVKTEPKPECMGAFMLFHMTKDSSCYLENTWFWVADHELDRSDHSQINLYNGRGVLIESTKGAWLWGTASEHSVLYNYHLQDASNVYMSLIQTETAYMQGNPDATVPFTVNAKYHDPDFKATCTGDSNRCARTWGVRAVGSNDIFIFGGGLYSFFDNYDQVCVGENNCQDNMISIESSKVHLYGISTKASVSMVNVEGKPVALDKDNRNNFCAAIARFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKV6</accession>
    <name>A0A1C3YKV6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FGRAMPH1_01T21397</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB65012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKV6"/>
    <dbReference type="STRING" id="229533.A0A1C3YKV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21397"/>
    <dbReference type="eggNOG" id="KOG4231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YKV6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="12"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="55"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SCB65012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="548" mass="62123" checksum="C75F25A62C76BC8E" modified="2016-11-02" version="1">MSSDSTKELKFLSLDGGGVRGLSSLFILKNVMERVGSKMKRRDLQPYQYFDLIGGTSTGGIIALMLGRMRMSIDDCITEYQRLGSIVFGKRRHGEYMFDEKVLVRETKAVVLKYLGNEDAPLLDPLEDDACKTVVYTLPFKNAVQQSATALRTYINEDKDPNPKKWTIWEAVRATSAATTIFEPFIHGPPGKQIRYIDAGFGYNNPSDLILQEARSLWEGDHYLSLHTDVGVFLSLGTGMGEIVRMDNDTVMEGLSAKIRAPVKAIEVMKNIVTGTATIHRNVAEQFGINSVRYYRFNVDHGLEAVKLFDYKKTEDMEVDTLAYLDKIEVGKELKRCVEVMKVLPLREPSLLDNQNEEANVYSLGANGSPEEQRLMDRLNALRIKPKCYTRHCKEWESEVNKEGARYHKLLYTELGIGYMWSAVVQADLLDERGREILSSCTPNPDRPQLLVSHDCKADAYYSPKDETPQRTAARIALANKDLSNAFQIFRQLLCTVVGIWDESSFPYCWIAKRMAGILEIWGCRREARNLYLVARDGKVKVFGEDHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YL67</accession>
    <name>A0A1C3YL67_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FGRAMPH1_01T25017</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YL67"/>
    <dbReference type="FunCoup" id="A0A1C3YL67">
        <property type="interactions" value="882"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YL67"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25017"/>
    <dbReference type="eggNOG" id="KOG0290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YL67"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000561">
        <property type="entry name" value="Putative WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="411"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="454"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="566"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="118"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SCB65280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="661" mass="70645" checksum="9E1647CFDDE72802" modified="2016-11-02" version="1">MSQSQQFPPSLRQMQVGSMSAPRAVAGPGAGSGSGSGSGSGPQPHPQHDELHMSGLSQTGGPISMSPQEYENPPQIKFESSPSNSHYRNPSNTSVPNVLQPAGGLSARGAPTSPNLPSPMQQSSPAASSVPHQPPSQAQQQQLPHHSQQPLQIPLQHGQPTRGYSGSPSAAVASKPPLSMSHSYSRSSPAAGYDGSSSYHAYTPTTPGGSTSAHLMSPIDTTRYNAPGSQRNISNTPLGLADIRPRADSSMSDGTGAAMAYDANNAQPGTSNYLAPWAIYAFDWCKWPAQGNSAGKLAVGSYLEDGHNFIQILDSHITPTPQDIYTPGSSKFSLEFTKAAEATHSYPVTRLLWEPPSSQKQSTDLLATSGDHLRLWSLPSENPSTPSGTIGRRDNVTTKLTPLALLSNSKTPDHTAPLTSLDWNTVSPSLIITSSIDTTCTIWDIPSLTAKTQLIAHDKEVYDVRFCAKSVDVFVSCGQDGSVRMFDLRSLEHSTIIYEPTGKEERDPNGGRVSPTLAQQTMSNPPPLLRLATSPHDTHLLATFAQDSNAIRILDVRQPGQALLELRGHAGNINSIEWSPHRRGMLASGGDDCQVLLWDIYNSGQPINGAPQQDNPRSPVASWQCDYEIGNLGWVPQLPNSEYGEWLGIGAGRGIWGTRVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YM16</accession>
    <name>A0A1C3YM16_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T09441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YM16"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09441"/>
    <dbReference type="eggNOG" id="ENOG502SPD0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YM16"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB65572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="195" mass="20790" checksum="0AFF0402CF981CAF" modified="2016-11-02" version="1">MGCVLKLVYYLTITIIANLFSSSLTTQSLASTSTTTFHSTFQNNHSTANMQFSLAFLAAVLSATSVSAAPTEQAVNMMAAAPQWTIESMQRSCAKDDSSCTWNFKIDTHKGAATACKFVVKGSKASQRNGGPVKCGDYTVTSGWSGQFGPGNGFTTFSVVSSKRQIVWPAYTDKQVQGGKVVKPDQSYAPANLPN</sequence>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YMA4"/>
    <dbReference type="STRING" id="229533.A0A1C3YMA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09253"/>
    <dbReference type="eggNOG" id="ENOG502SX1Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YMA4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SCB65568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="269" mass="31219" checksum="D140AE5B504D390B" modified="2016-11-02" version="1">MAQPVIDEEDDPFWIYDDVFRIARFEGDPRCKRSVIHRLDTTLTLRHGHKPKKWGFAIIRTDYGPGSDQKLEYALEIINNIAQHWVEDEVEGLKFRITQGKETDFRYKDVPVEVDTRPNEEFVRRYENDVVEDQSLENASFAAVREYFKTWIASKGGRSNVGNTRYVACIMLDAETLSQLATAPKGFPHGCDVYSSSYWVKMVDVEASPDEAIHVRVRGTDDLMKYWFTRNMIRSHVLTHRKDREYPGVLYFGDPPSLGFEEMECPPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMV4</accession>
    <name>A0A1C3YMV4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromosome 2, complete genome</fullName>
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    <gene>
        <name evidence="12" type="ORF">FGRAMPH1_01T13425</name>
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    <organism evidence="12 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YMV4"/>
    <dbReference type="STRING" id="229533.A0A1C3YMV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13425"/>
    <dbReference type="eggNOG" id="ENOG502QVSV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YMV4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.90:FF:000001">
        <property type="entry name" value="L-serine ammonia-lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051318">
        <property type="entry name" value="Fe-S_L-Ser"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30182">
        <property type="entry name" value="L-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30182:SF1">
        <property type="entry name" value="L-SERINE DEHYDRATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="Serine metabolism enzymes domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine dehydratase beta chain" evidence="11">
        <location>
            <begin position="82"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Serine dehydratase-like alpha subunit" evidence="10">
        <location>
            <begin position="354"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="291"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SCB65836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="712" mass="76037" checksum="68F3F6D9FF640B70" modified="2016-11-02" version="1">MSRAGFKQLSLFRASKQCLSTRSLATIARWPNHNAVARSAPVSATKLRARPFSTTRPRRTQDEMEDESSSYSEADHEHAVISTFDLFSIGIGPSSSHTVGPMRAGNIFVNDLIEANLLPKVNKIRVAIYGSLALTGEGHMTPSALLLGLEGNDVETVDTAYVPTRFNDIKTTKKIFLGRGLAADGSKGKEIDFDYEKEFIWEWGRKLPQHSNGMRFTVFDKEGYVLATNDMFSVGGGFVVNGALSIAPQQTLSPNDPAQLEDPELESAAHPADLAENLYYKEIRRSDAAGDRRTGSEVKALDEANAGPTALLGESAEPTGLSTDVKSETKSTSSSPHPRYAFRDAASLLSLCRKHNLTIAQLVYENEKSLGYTDEDIYRKIFKIWGVMDASILESVQAAPGTKLPGSLKLHRRAPALYRRLTRGLYPSSTADTSAAQLEHKFSAPDPNIGEDGASPQPGALTSPSGILSASPPDKFVAGALRKRGPPRIHGSLTHPIAPAPSRRTTFPTMDYLSVYAIAVNETNADGGRIVTAPTNGAAGIIPAVLKYTTEFISDDPERDIPTFLLTAAAIGMLYKRGATISAAEGGCMAEVGVACSMAAGAFAACMGASPETIEQAAEIGIEHNLGLTCDPIGGLVQAPCIERNALGATKAISSANLALSSETGTQRVRLDDAIRAMRLTAKGMRNEFKETSLSGLATSVHINIPVSVPDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I1R995</accession>
    <accession>A0A098CZ16</accession>
    <name>I1R995_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG00024.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T00097</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF71848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315609.1">
        <property type="nucleotide sequence ID" value="XM_011317307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1R995"/>
    <dbReference type="STRING" id="229533.I1R995"/>
    <dbReference type="EnsemblFungi" id="CEF71848">
        <property type="protein sequence ID" value="CEF71848"/>
        <property type="gene ID" value="FGRRES_00024"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00024"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00097"/>
    <dbReference type="eggNOG" id="ENOG502RZX2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035614_3_0_1"/>
    <dbReference type="InParanoid" id="I1R995"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052907">
        <property type="entry name" value="Beta-lactamase/esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319:SF3">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="16"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF71848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF71848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="379" mass="41743" checksum="0892FE5AF1595C12" modified="2012-06-13" version="1">METVHGICSPQFQGVRDLLENYIKSNEELGASLTINVNDEVVVDIWGGHKDQERKEPWEENTIVNVFSSTKTVTSLAVLILVDRGMIDVNERVSKYWPEFGQNGKEDVLVRHLLSYASGVSGWEEPLSTEDMYDLDKSTPMLARQAPWWTPGTASGYHALTYGHLLGELIRRVSGKSLREFVATEIAGPLDADFQIGASENTWDRVTPIVPPEASGITADFDVKSVQGRTLLNPPIDPNSANSEGWRKAEIGAANGHANSRSLVRIMSAITLRGETGGKRILKEETVKLIFEEQQSGEDLVMKVPFKLGIGFGLTPCAALDWIPEGNVCFWGGWGGSFVVMDLDRRMTISYTMNKMGSGLVSSDRAAVYGKAIYDAVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RA64</accession>
    <accession>A0A098D2Y9</accession>
    <name>I1RA64_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG00389.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T01017</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316051.1">
        <property type="nucleotide sequence ID" value="XM_011317749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RA64"/>
    <dbReference type="STRING" id="229533.I1RA64"/>
    <dbReference type="EnsemblFungi" id="CEF72311">
        <property type="protein sequence ID" value="CEF72311"/>
        <property type="gene ID" value="FGRRES_00389"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00389"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01017"/>
    <dbReference type="eggNOG" id="ENOG502QQXH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_4_3_1"/>
    <dbReference type="InParanoid" id="I1RA64"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF12">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="38"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF72311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="537" mass="59919" checksum="BDC33B2718D1105A" modified="2012-06-13" version="1">MSTLVNNLLSKLTTEENGDTKSQPQPPPKPEMSETPPRFLIIGAGSRGQNYAAAIDSVSNGVVAAVAEPLKFKRESLGRDHIWGNGSPKEGQSFHDWRDFLAYEQDRRRRVAAGDENVPEGVDGVFVCVLDEMHREVIVGLAPLELHTMCEKPLACSLQDCVDMYKAMRPYQPSKVFSIGHVLRYSPHNIMLRKLLVEDRVIGDISSAAHTEPVGYWHFSHSYVRGNWRNENTTAPSLLTKSCHDIDLLLWLLCSPEKAGQGEPHIPATVASSGGLHLFKKSRKPKAAGSATNCTKCPLGDEGCKFSAKNIYLGPKLKGLQSGNTGWPVSIVVHDIEDYPSQEEKEEQVMKALVEDYDESTPKSEVQSRNWFGRCVFEADNNVCDDQFVTITWPESTQPAKTATLHMVAQTTKICERYSHFYGEHGEVYADSRRIVVEDFNTGETKTYHPRVEDLGHGGGDLGLTRQFVMACDRVKNHGWEAPRAQDEFIGCTLDDVLRSHAMVFAAEEARLGRKVLDWEEWWDKALGKQLGLNGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1RAY5</accession>
    <name>I1RAY5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG00681.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T01717</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316380.1">
        <property type="nucleotide sequence ID" value="XM_011318078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RAY5"/>
    <dbReference type="EnsemblFungi" id="CEF72659">
        <property type="protein sequence ID" value="CEF72659"/>
        <property type="gene ID" value="FGRRES_00681"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00681"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01717"/>
    <dbReference type="eggNOG" id="ENOG502RW4V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_211153_0_0_1"/>
    <dbReference type="InParanoid" id="I1RAY5"/>
    <dbReference type="OrthoDB" id="5242790at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF72659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="57" mass="5937" checksum="2094BEAE7EE63936" modified="2012-06-13" version="1">MPAPMEPTQQAPMTSDNGDIVTQQPTAEPQPDMSMRGGEEAGCEICCGLCACDEGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RB46</accession>
    <name>I1RB46_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG00751.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T01895</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316460.1">
        <property type="nucleotide sequence ID" value="XM_011318158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RB46"/>
    <dbReference type="FunCoup" id="I1RB46">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RB46"/>
    <dbReference type="EnsemblFungi" id="CEF72748">
        <property type="protein sequence ID" value="CEF72748"/>
        <property type="gene ID" value="FGRRES_00751"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00751"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01895"/>
    <dbReference type="eggNOG" id="KOG1509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040416_0_2_1"/>
    <dbReference type="InParanoid" id="I1RB46"/>
    <dbReference type="OrthoDB" id="10267058at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF72748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="269" mass="29654" checksum="2D0BCCD1EE343F37" modified="2012-06-13" version="1">MADAPSGPPPDYDKSTTSQGTAQRPLRKGPLPLELPILKHLNSKRVILASASPRRKALLQQFGLSNLEILPSTKPENLDKAALGPFEYVAATAHQKCMDVYTTALEVHLKSIPDPDLVIAADTVIVTKDGRILEKPRSEADHIRMLKHLRDQRMHKVLTAVTVLAPREDARHPGYEIDSYTEETKVYFLSETEGLPDDVIEAYVKTREGADKAGGYAVQGIGGMLLVEKIEGSVDNVVGLPVRKCMAMAEKVIFRQQEEDFEGEGSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>I1RB73</accession>
    <name>I1RB73_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG00780.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T01959</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_011318189.1"/>
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    <dbReference type="AlphaFoldDB" id="I1RB73"/>
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        <property type="interactions" value="1040"/>
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        <property type="protein sequence ID" value="CEF72780"/>
        <property type="gene ID" value="FGRRES_00780"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_0_0_1"/>
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        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:Rpd3S complex"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="RPD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
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    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
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    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="39"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="382"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="434"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="404"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="631"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF72780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="649" mass="72157" checksum="7D33BB05E274A7DD" modified="2012-06-13" version="1">MGDDIRVELGSVALNASSPKKVAYFYDSDIGNYAYVTGHPMKPHRIRLAHSLIMQYNLYQKMEIYRAKPATRGEMTQFHTDDYIDFLQKVTPDNMDSFMREQGKYNVGDDCPVFDGLFEFCGISAGGSMEGAARLNRQKCDIAINWAGGLHHAKKCEASGFCYVNDIVLGILELLRFKKRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGELRDTGIGQGKNYAVNFPLRDGITDASYRSIFQPVIENVMKYYQPEAVVLQCGGDSLSGDRLGCFNLSMDGHANCVNFVKSFNLPTLVLGGGGYTMRNVARTWAFETGVLVGKEMDRTLPYNEYYEYYAPDFELNVRSSNMENSNSREYLEKITSSVIDNLRQTGPAPSVQLQDVPRKPFGGMTDEEEAELDDLDEDENKDVRMTEHRWDKHVEHDNEFEASDDDEMARVNGATRQNGNKRSFTDYRKGEMDVDNPDAPPAKAPNGASNDEAAEEHTGEDGHDVNDDTIDDISAPDQPEKDQPEKATETPTENAKEPELSKVDGDGDVGMEDSAVEETTIKKEDVEPEAPEAPTEPSAPTEKSAQDEPTVEAAANDAATTEPIPEPTPAEKPAESTEKAQSEQPADAMDVDTEKDKPEQPKEKSKSPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1RBA8</accession>
    <name>I1RBA8_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG00820.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T02053</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316534.1">
        <property type="nucleotide sequence ID" value="XM_011318232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RBA8"/>
    <dbReference type="STRING" id="229533.I1RBA8"/>
    <dbReference type="EnsemblFungi" id="CEF72826">
        <property type="protein sequence ID" value="CEF72826"/>
        <property type="gene ID" value="FGRRES_00820"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00820"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02053"/>
    <dbReference type="eggNOG" id="ENOG502S5JC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015147_1_0_1"/>
    <dbReference type="InParanoid" id="I1RBA8"/>
    <dbReference type="OrthoDB" id="21060at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID component TAF4 C-terminal" evidence="10">
        <location>
            <begin position="344"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="412"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="466"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="562"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF72826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="647" mass="69454" checksum="8CB1381495A11A6D" modified="2012-06-13" version="1">MAQPQPQAQPQTQTQVQVPPRAFSPPQHSPSPAASQPTFALPPQKRVRTEGPSSQPESPYATSPYAASPGATATPPAATGSPAFAQSPALPQAYSTPYTNGHTTPGLNLPDVRPNSTPPIQQPQQPQTPVPQYTNVTMTPVPLPGPGQLAVPTPGPSVMGPPQRPAERPTKDYEYDVTDSLAGTGIDLRAEEQYMNDLYATGFDEARTGFAHQPPGPKSTFYGAGPANQPAQPVQDQQQEQFAAQQAERAWSESSMRLALQRTQEISEPFLLVAMLHRRADKIAREHHLGLNLDLKNNSQTMGKMRLPEQFAAPKVTVKVTPGPDSTMVHTTGSYIPHDAYLVDQLALMSIATKQRLRELVEDAHLVATNRQKTSHGDIPEEWSPAAAPMNVEPLEPIEKPTDSVNGVEATVESADGDSTNPLKRSSDTAGLTSGAPPVKLPKVSSYMTTTMRDLARQERDWEEARLRKRQKRKDGIPDSGSTTSRAGSVAPGTPGTAAPEAPKSMTKKEIKKNQQLKAAEIDNHQSQNTTSSIFAGFGGKGGLFGKKKTGKTYDWMNVGRGGSGASTPTRSAPGLGKGPGGAGAAPAPANMAMTTEGRNRLGTWREDKEKGRNIQLRDWAAVLERDGREAKALQRAYLYLDASNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1RBD3</accession>
    <name>I1RBD3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG00849.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T02125</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316571.1">
        <property type="nucleotide sequence ID" value="XM_011318269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RBD3"/>
    <dbReference type="EnsemblFungi" id="CEF72863">
        <property type="protein sequence ID" value="CEF72863"/>
        <property type="gene ID" value="FGRRES_00849"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00849"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02125"/>
    <dbReference type="eggNOG" id="ENOG502QRB5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034574_2_0_1"/>
    <dbReference type="InParanoid" id="I1RBD3"/>
    <dbReference type="OrthoDB" id="4480814at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G07470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF72863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="342" mass="37155" checksum="2FD7C5C77418F9F9" modified="2012-06-13" version="1">MGVGRFFCVLLPFALTIGSIIFLLVGALAGVADKSLYIFRVDVEDLSISPADVDNIVDNLGLKDFKFNTRDVPQLMVRAEDGAPIKDNITAKMLGLDKYYDINLWGFCKIDKDGKRKCEKPEFDWASKSLNTSTLVGTNKNIAIQLPDEIQSALKAFRTATKWTQVVYIAAFIALAAEIILGIFTNCSRIVSCLTWIVAGIATTLVIGSVVLSGVLAGTVVGAVEASAKFYGVKGHINGRFFACVAISAAFALAAGLFWMFTICCCKPESRSDKKKNRRSDGEKLLGGAGNKHGSYAPLSDDHEMQSGYYNHNQAQSQYGAPRYPSGTARSDLAYEPYSHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RC00</accession>
    <accession>A0A098D2J1</accession>
    <name>I1RC00_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG01099.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T02743</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316862.1">
        <property type="nucleotide sequence ID" value="XM_011318560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RC00"/>
    <dbReference type="FunCoup" id="I1RC00">
        <property type="interactions" value="1468"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RC00"/>
    <dbReference type="EnsemblFungi" id="CEF73173">
        <property type="protein sequence ID" value="CEF73173"/>
        <property type="gene ID" value="FGRRES_01099"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01099"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02743"/>
    <dbReference type="eggNOG" id="KOG0096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_13_0_1"/>
    <dbReference type="InParanoid" id="I1RC00"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF73173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="216" mass="24467" checksum="75A31D05EE2C305D" modified="2012-06-13" version="1">MAEQQTPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYMATLGVEVHPLGFTTNFGQIQFDVWDTAGQEKFGGLRDGYYINGQCGIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLCGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGNPQLEFVAAPALAPPTALVDEKLLEEYRKEMDEAAAMPLPGELSDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I1RCF3</accession>
    <name>I1RCF3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG01267.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T03139</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317047.1">
        <property type="nucleotide sequence ID" value="XM_011318745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RCF3"/>
    <dbReference type="FunCoup" id="I1RCF3">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RCF3"/>
    <dbReference type="EnsemblFungi" id="CEF73371">
        <property type="protein sequence ID" value="CEF73371"/>
        <property type="gene ID" value="FGRRES_01267"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01267"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03139"/>
    <dbReference type="eggNOG" id="ENOG502S9SB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137480_1_0_1"/>
    <dbReference type="InParanoid" id="I1RCF3"/>
    <dbReference type="OrthoDB" id="2567806at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF73371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="113" mass="12526" checksum="CB1180B216CFD1A6" modified="2012-06-13" version="1">MARGETQQTKVHFKGSDDFVIFIDDVETYQKWKTDKSVPLAHFISSFKIFCTHGQGAQGTLDAASKAALENEFGTSVDDDVIKQILEKGETQNTEFPERQGSKNDSKGPMASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1RCZ4</accession>
    <name>I1RCZ4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG01481.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T03637</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317290.1">
        <property type="nucleotide sequence ID" value="XM_011318988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RCZ4"/>
    <dbReference type="STRING" id="229533.I1RCZ4"/>
    <dbReference type="EnsemblFungi" id="CEF73624">
        <property type="protein sequence ID" value="CEF73624"/>
        <property type="gene ID" value="FGRRES_01481"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01481"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03637"/>
    <dbReference type="eggNOG" id="ENOG502RX7P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057565_0_0_1"/>
    <dbReference type="InParanoid" id="I1RCZ4"/>
    <dbReference type="OrthoDB" id="4001642at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053060">
        <property type="entry name" value="Cytokinesis_Signaling_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419">
        <property type="entry name" value="ARRESTIN FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419:SF1">
        <property type="entry name" value="RHO1 GEF LOCALIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="1">
        <location>
            <begin position="187"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF73624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="403" mass="44838" checksum="88EA8E9B286A1109" modified="2012-06-13" version="1">MAAPASVRVSGPPNSSFLVGYPGISATLPRIEGKVEIRPGQGFSMPVPVSLVRICLQRRETIHPDADSIAKRHLGAPRRETTDLVGKEQLLFRCSSGKEAERIIAMDLPFVLFIPYGRGGEESNRRIPPASLQLPSRTAETYYELVVTVQQGHSNQYKYTFPIPLQRYDTLSTFGMYNKPESKLVTNDNIVHLGINLPRWSYGPSDPITVYIKLSPNLDWLSKAKRVTIDKITLTVEEEITYNPEGDEPSKKINKISRQVQVVKTKMPEAGYATNVGLVFPSKDLRDPDGVVKRGKPQFPLYEVTSFTTTSTLYKIEFYLVIKVNLSGARDVTIRQPIVICPIDQQACKEEMDAIEQAAKDASHVDPNNPMLPAPTVILANDRDSLRALGLCMVGGQKKPFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RD61</accession>
    <name>I1RD61_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">FG01550.1</name>
        <name evidence="19" type="ORF">FGRAMPH1_01T03781</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="20">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="21">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="20">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="19 21" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="19">PH-1</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317361.1">
        <property type="nucleotide sequence ID" value="XM_011319059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RD61"/>
    <dbReference type="STRING" id="229533.I1RD61"/>
    <dbReference type="EnsemblFungi" id="CEF73696">
        <property type="protein sequence ID" value="CEF73696"/>
        <property type="gene ID" value="FGRRES_01550"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01550"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03781"/>
    <dbReference type="eggNOG" id="ENOG502SG7I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138063_0_0_1"/>
    <dbReference type="InParanoid" id="I1RD61"/>
    <dbReference type="OrthoDB" id="3230169at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013963">
        <property type="entry name" value="DASH_Dad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08654">
        <property type="entry name" value="DASH_Dad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CEF73696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="143" mass="15074" checksum="4AC4E2808FA53E79" modified="2012-06-13" version="1">MSYPTRSLSSHMRAPSASASSSGQSPALIARIEEKKAELENLKELRELSAAVATQMEALEQKLSTLSDGTEAIAAVVGNWHNVLRAINMASSKLAKTAADQTQAPEQSTGPLPQTLVRIPTEHAPALQAQAEAAEAAAEEQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RDC7</accession>
    <name>I1RDC7_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG01621.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T03959</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317446.1">
        <property type="nucleotide sequence ID" value="XM_011319144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RDC7"/>
    <dbReference type="STRING" id="229533.I1RDC7"/>
    <dbReference type="EnsemblFungi" id="CEF73786">
        <property type="protein sequence ID" value="CEF73786"/>
        <property type="gene ID" value="FGRRES_01621"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01621"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03959"/>
    <dbReference type="eggNOG" id="ENOG502QXN4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029718_0_2_1"/>
    <dbReference type="InParanoid" id="I1RDC7"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF1">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124097" description="cellulase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="8">
        <location>
            <begin position="36"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF73786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="335" mass="36863" checksum="7A987EB34C35187A" modified="2012-06-13" version="1">MRFTDLLLASAGATLALAAPSTEKRAAGKFLFTGSNESGGEFGETQLPGKLGKDYIWPTTKSIDTLASTGMNTFRVGFRMERMTPSGITGALDETYFKGLESVVNHITSKGNFAVIDPHNYGRYNNQIIQSTADFGAWWSKVAKRFANNKNVIFDTNNEYHDMENSLVAGLNQAAIDAIRKAGATSQYIFVEGNSYTGAHSWVSSGNGEALKNLKDPQNKIIYQMHQYLDSDNSGTHADCVSSTIGVERVKEATKWLKDNKKRGIIGETAAGPNTQCIEALKGELQYLHDNSDVWTGWLYWAAGPWWGDYMYSMEPDTGASYVKVLPEIKKFIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RDD0</accession>
    <name>I1RDD0_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG01624.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T03965</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317449.1">
        <property type="nucleotide sequence ID" value="XM_011319147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RDD0"/>
    <dbReference type="FunCoup" id="I1RDD0">
        <property type="interactions" value="377"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RDD0"/>
    <dbReference type="EnsemblFungi" id="CEF73789">
        <property type="protein sequence ID" value="CEF73789"/>
        <property type="gene ID" value="FGRRES_01624"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01624"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03965"/>
    <dbReference type="eggNOG" id="KOG3106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057784_0_0_1"/>
    <dbReference type="InParanoid" id="I1RDD0"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045015">
        <property type="term" value="F:HDEL sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00951">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF73789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="215" mass="24953" checksum="73CB84556D5A6F97" modified="2012-06-13" version="1">MPLNLFRVAADFSHLGSIFILLHKMVQLNSCSGISFKSQTLYMLVYITRYLDLFSTDSIYNFVFKILFLGSQGYIIYLMTNAYKPTNDPNVDTFRVQYLLAGAAVLAVAFPYHYTFSEILWAFSIWLESVAILPQLFMLQRTGEAETITTHYLFALGSYRALYIPNWIYRYFSETHHKVDTIAIVAGIIQTVLYSDFFYVYYTKVMKGKKFKLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1RE02</accession>
    <name>I1RE02_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG01872.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T04535</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317722.1">
        <property type="nucleotide sequence ID" value="XM_011319420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RE02"/>
    <dbReference type="EnsemblFungi" id="CEF74074">
        <property type="protein sequence ID" value="CEF74074"/>
        <property type="gene ID" value="FGRRES_01872"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01872"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04535"/>
    <dbReference type="eggNOG" id="ENOG502S85Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067863_0_0_1"/>
    <dbReference type="InParanoid" id="I1RE02"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF1">
        <property type="entry name" value="CONSERVED FUNGAL PROTEIN (AFU_ORTHOLOGUE AFUA_1G14230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124075" evidence="1">
        <location>
            <begin position="18"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF74074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="264" mass="27689" checksum="C9C7AD51B8784AD5" modified="2012-06-13" version="1">MQLSTFVASVLAVTASAAPSFPKPTITDTRSAIDTLGSLSGYFNLVAEKVKAAKAYDVAPVCDLSQAKMALDGQLLPPSKGLYLKHVAIGRGTQNYTCDTKNPSSAPVATGAVATLFNASCAAALYPDLVERIPGMAVHFPLTDAAKLGPASFPESGHHYFTADGVPFFDLRTPEQTIGEAPCAKNSSAPAPSFSAKGQLGEAAVPWLRLFTIKGATHDIKEVYRTTTAGGSAPATCNGMASEFEVQYATLYWFWAGKTDDAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>I1REJ4</accession>
    <name>I1REJ4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG02083.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T05025</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317958.1">
        <property type="nucleotide sequence ID" value="XM_011319656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1REJ4"/>
    <dbReference type="STRING" id="229533.I1REJ4"/>
    <dbReference type="EnsemblFungi" id="CEF74319">
        <property type="protein sequence ID" value="CEF74319"/>
        <property type="gene ID" value="FGRRES_02083"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02083"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05025"/>
    <dbReference type="eggNOG" id="ENOG502RXSB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016574_2_1_1"/>
    <dbReference type="InParanoid" id="I1REJ4"/>
    <dbReference type="OrthoDB" id="4132249at2759"/>
    <dbReference type="PHI-base" id="PHI:1931"/>
    <dbReference type="PHI-base" id="PHI:5259"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="620"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="620"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF74319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="656" mass="73219" checksum="202E3264D188FC87" modified="2012-06-13" version="1">MAGTIQKRACDGCHRRKVKCDSNSPCRNCNTANIQCTYNAIPQKKGPKGSRAKVISELRENQRLTSLPVKVQARMSGVPTESIQNHNVTNGLLTAEFAKSCLNFFFDNLYSKLPILDRDVIESQLSCMERDTEIYCLFTSLCAFMMLQPGMGFPTADYNLQMEPGANIAASNILVEECLRVRKGTEHWENPSHYVLATNYFIFAFYYSQQSHASAWYYLREATTMIQMSDQNNEGKYLQDMESIRRRRLYWLLFNAERAYAIQRSYPLTLQATVHTGNYGEDPADNLNPSIQNNFFNMCSVFQSIDDNFLSTWRHPCCRLDNQIIASLDAQLLKTVPTYPPNAALQAVQGWLKTVAWQTSGDTQENVAYRMSQFVSGFPNPAMLMNSGLIAKLLQVTSDLICYLVNAPQSRNPTTQGPERYLQTLLRICLAIQNNHYQFVPLLLSKVNEYLPRIVDPMLLNPPENVGYGMSVDIFDGFGNAGMAQMPMGDYNPGLPMNSYEPKYEDMGGNSPDSLPHSHHSHHSNGSPPGSQMGNEMPQNFVSSPGTVMSPGMDYTPSMGGFSISDMVMSPLGGAAPPNGINMQRQQQQQLNNQPQMQGMSNQGIGAPPMNQNIGSLYSGVRQPSRQSSFNMQSQTPLSAMGSMSDAMDFNTLPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1REJ5</accession>
    <name>I1REJ5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 1, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="7" type="primary">FG02084.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T05027</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_011317959.1">
        <property type="nucleotide sequence ID" value="XM_011319657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1REJ5"/>
    <dbReference type="FunCoup" id="I1REJ5">
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    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF74320">
        <property type="protein sequence ID" value="CEF74320"/>
        <property type="gene ID" value="FGRRES_02084"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02084"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05027"/>
    <dbReference type="eggNOG" id="ENOG502QURG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_3_1_1"/>
    <dbReference type="InParanoid" id="I1REJ5"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="RTA1"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EnsemblFungi" id="CEF74320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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        </source>
    </evidence>
    <sequence length="304" mass="34004" checksum="C0C8299D3E20CF4D" modified="2012-06-13" version="1">MAGSDAPQAYVFYNYNPSMVAAVIFIIVFGLSSLLHTFQLVRARTWYFIPFLIGCLFECVGYIGRALSANEAPDFTKNPYIIQSILLLLGPALLAASIYMVLGRLIVLLDAGHLSVIRPNWLTKVFVTGDVLSFLAQSAGGGMLATAKDKDAVKRGENIIVGGLIIQILFFGFFMIVTLIFHARINRNPTQKSLEIVAPWKKLLFALYAASLSILVRSVFRVAEYVMGKDSALQSQEFWIYIFDALLMSLVVVSLNWFHPSRVINGALDRKRIVSQDEYMLEGQRHDGERQRYSLSPVRPKGNN</sequence>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
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    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_011318005.1">
        <property type="nucleotide sequence ID" value="XM_011319703.1"/>
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    <dbReference type="EnsemblFungi" id="CEF74368">
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        <property type="gene ID" value="FGRRES_02127"/>
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        <property type="entry name" value="BAR_MUG137_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="3">
        <location>
            <begin position="15"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF74368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="403" mass="45288" checksum="E001D9C77B631527" modified="2012-06-13" version="1">MHFTKKIDRAFQWAGEKMGGEARTAHSDEFKNLETEMALRQDGMEKMQKSMTGYVKWLSRRNELMEDKERGTPMSALGRTMATHGEDFEQDSEFGNCLLSLGRANERIAGIQDSYVDSANATWLDNLERSLAMMREYQNARKKLENRRLAYDASTNKLQKARRDDFRVEEEVRMNKAKFEETSEDVLRRMQDIKETEVDNISSLTQFLEAELDYHERCAEELRRVRQSWAGGASSPTSAPKIGRSRSNTARSWQEPRHQAVYEEPEPEQESARIPHRSPASRLAPPPPQPARPPIGRASTFEGRSSTATPLANLRVPGAPLTRVATDGGSYGRHDDVFSDDVSTSRSGSPDWEQRAASPATSYGSLSRSTSGLALGKKPPPPPPNRAKKPPPPPPARRENLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RG45</accession>
    <name>I1RG45_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG02694.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T06451</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the germin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318645.1">
        <property type="nucleotide sequence ID" value="XM_011320343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RG45"/>
    <dbReference type="STRING" id="229533.I1RG45"/>
    <dbReference type="EnsemblFungi" id="CEF75030">
        <property type="protein sequence ID" value="CEF75030"/>
        <property type="gene ID" value="FGRRES_02694"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02694"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06451"/>
    <dbReference type="eggNOG" id="ENOG502SINP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061239_3_0_1"/>
    <dbReference type="InParanoid" id="I1RG45"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124185" evidence="6">
        <location>
            <begin position="23"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="7">
        <location>
            <begin position="49"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF75030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="233" mass="24643" checksum="FBC772A03067471C" modified="2012-06-13" version="1">MFSNAKLSVITAFLAYSSIATAAPQGKDMATEAGLVTKLQQAESVIDRYNLLPEDKDFHFSFNSTPARNANGKTFPALTGAGISLAFAELPGCSMITIHTHPRAAELFAVISGNLYTEAVPESGVLDKQGKPRVIRNELGAGEATIFYQGAMHYQINTDCDPALALAAFPSEDAGFAGVAAGLFSVKNEALINSFGEVIKGEDVDKLRGGIPQVASIKVTECLAKCGKQKRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RGD7</accession>
    <name>I1RGD7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG02796.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T11335</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323017.1">
        <property type="nucleotide sequence ID" value="XM_011324715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RGD7"/>
    <dbReference type="EnsemblFungi" id="CEF77470">
        <property type="protein sequence ID" value="CEF77470"/>
        <property type="gene ID" value="FGRRES_02796"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02796"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11335"/>
    <dbReference type="eggNOG" id="ENOG502T5IJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1441124_0_0_1"/>
    <dbReference type="InParanoid" id="I1RGD7"/>
    <dbReference type="OrthoDB" id="4778315at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="201" mass="22126" checksum="DD06D94661957C71" modified="2012-06-13" version="1">MNGAQSPDAQKALNANSNGSNSNNSSLAAKKRKKDLKPIITMEDTSQTDGNLYAGLLYELRRHQHILVLDLLMSREWRGRWRFQQNKHDPIQVFKKHPAKHGVASCITSQRRAVKQVQTSVDIAHGGIVPSALSLSLWRTVGLGLDRTTRPHKYWALTNLESVDRSLGPLYLISACPVCLDRGALGHSPTASFEVPGIALG</sequence>
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    <accession>I1RGQ9</accession>
    <accession>A0A098DGQ0</accession>
    <name>I1RGQ9_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322869.1">
        <property type="nucleotide sequence ID" value="XM_011324567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RGQ9"/>
    <dbReference type="STRING" id="229533.I1RGQ9"/>
    <dbReference type="EnsemblFungi" id="CEF77627">
        <property type="protein sequence ID" value="CEF77627"/>
        <property type="gene ID" value="FGRRES_02932"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02932"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11647"/>
    <dbReference type="eggNOG" id="ENOG502S445">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070836_0_0_1"/>
    <dbReference type="InParanoid" id="I1RGQ9"/>
    <dbReference type="OrthoDB" id="58379at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="268" mass="30868" checksum="1B8C0CA080BCE6E4" modified="2012-06-13" version="1">MSEKTKSPFYDYAEPATSSPTPPRLGKAIQNVLTTRSHFATITRSALDRINLINFSETEIAAIHEVVNKNWWKGITAVYPREQSREFKLKGYPWGYDPNGCEDSLLLVLRMIETLYNMGWVIYSAIEISKRVRTTDALVFRRQYHILPPCEWVSISFHGGDKLKILNSPPSQLVNDVIAAFITDIQRHEVTAERAKIKFKGFPWRSVGHDDEDETQMKLLTLLEVVERNGFTLYARTTARYSDETSESNVLIFQRRPDWVSGTSVYDR</sequence>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I1RGZ1</accession>
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            <fullName evidence="7">Chromosome 2, complete genome</fullName>
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        <name evidence="8" type="primary">FG03024.1</name>
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    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="protein sequence ID" value="CEF77741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_011322762.1">
        <property type="nucleotide sequence ID" value="XM_011324460.1"/>
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    <dbReference type="AlphaFoldDB" id="I1RGZ1"/>
    <dbReference type="EnsemblFungi" id="CEF77741">
        <property type="protein sequence ID" value="CEF77741"/>
        <property type="gene ID" value="FGRRES_03024"/>
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    <dbReference type="KEGG" id="fgr:FGSG_03024"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11877"/>
    <dbReference type="eggNOG" id="ENOG502QV03">
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    <dbReference type="HOGENOM" id="CLU_030057_2_0_1"/>
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    <dbReference type="OrthoDB" id="2901184at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="TDT_Mae1_like"/>
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        <property type="entry name" value="Voltage-dependent anion channel"/>
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        <property type="entry name" value="Mae1"/>
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        <property type="entry name" value="SLAC1"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="EnsemblFungi" id="CEF77741"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RH01</accession>
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        <name evidence="9" type="primary">FG03035.1</name>
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    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_011324448.1"/>
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    <dbReference type="EnsemblFungi" id="CEF77753">
        <property type="protein sequence ID" value="CEF77753"/>
        <property type="gene ID" value="FGRRES_03035"/>
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    <dbReference type="eggNOG" id="ENOG502SP40">
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    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="AltA1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AA1"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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            <end position="17"/>
        </location>
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    <feature type="chain" id="PRO_5010124165" evidence="6">
        <location>
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            <end position="149"/>
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    <feature type="domain" description="AA1-like" evidence="7">
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            <begin position="17"/>
            <end position="142"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF77753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="149" mass="15466" checksum="9721A9078380FC7E" modified="2012-06-13" version="1">MRFSVCTALTLAAGALAAKEKVTVSKLSIHSVGSPVGTSIKSVSFVLNGDDANNLKCSAKNVAFPVPDDILSCGDSNYAFTLWEGEKGAKFRVMVYHDVGDSHADLRGGADIRTKCDNSQGSGPADEICTQVKPVSFTIDGPVGSSPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1RH42</accession>
    <name>I1RH42_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG03083.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T12019</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322692.1">
        <property type="nucleotide sequence ID" value="XM_011324390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RH42"/>
    <dbReference type="EnsemblFungi" id="CEF77813">
        <property type="protein sequence ID" value="CEF77813"/>
        <property type="gene ID" value="FGRRES_03083"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03083"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12019"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="InParanoid" id="I1RH42"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF78">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="26"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="522"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF77813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="554" mass="61511" checksum="2081C6E8C186D1B7" modified="2012-06-13" version="1">MTGTMERLPGFNVANHFEKRQLLIAINCVAALSIFFFGYDQGMMGGVNNSKHYIDLMGFGYVDEKTGEPVVTDSLLQGGIVSVYYLGTLFGCLFGGWIGDKLGRIKTIAVGAAWAILGAALQCSAQNHEWMICSRAVNGIGTGILNAIVPVWATETAEHTSRGQFIAIEFTLNIFGVVVAYWLEFGLSYIDNNGSQFGWRFPIAFQIIPLLVLLGCVWFFPESPRWLVKVGRDDEAQYILQRLRGSSEIDRARAHAEYTDIKNIVQLENKESSKNSYFHMFFGIGSGELHTGRRVQLVIWLQIMQEWVGIAGVTVYAPTIFRIAGFDTKKSQWISGLNNIFYMFATLICVYTLDRIGRRWTLYWGAVGQGIAMFLAAAFSRLGQDARDAGDIAKANSYGAAAAAFVFIFTFVFGATWLTVPWLYPAEIFPLQVRAKGNAFGVFGWSIGNGWLTLLCPVMFSKIGENTLHIFGAANLLAIPMVWALYPESNQRTLEEMDLLFAADTPWVWDAEKKFKELKEQRPGLVSSSAHTRDVMDVEPGAKSASGDEVNMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RH85</accession>
    <name>I1RH85_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG03130.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T12131</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322639.1">
        <property type="nucleotide sequence ID" value="XM_011324337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RH85"/>
    <dbReference type="EnsemblFungi" id="CEF77869">
        <property type="protein sequence ID" value="CEF77869"/>
        <property type="gene ID" value="FGRRES_03130"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03130"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12131"/>
    <dbReference type="eggNOG" id="ENOG502RWPS">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_1722847_0_0_1"/>
    <dbReference type="InParanoid" id="I1RH85"/>
    <dbReference type="OrthoDB" id="4566586at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124241" evidence="1">
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            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="137" mass="15305" checksum="B40D19797DCC9FAD" modified="2012-06-13" version="1">MLSKTFFMTLLALGASAAPIEGEVQKDNIGKRCDWNDLHGQISCGYFSVVMSFDDITIRGDGWTQKYNIDCSREWSSLRGQLPWTVEFHPGNACAGTNYDNMWIKYADTTLDIPSDTRCGAVGPNNSLRRCIIADKK</sequence>
</entry>
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    <accession>I1RI27</accession>
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        <name evidence="8" type="primary">FG03448.1</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322268.1">
        <property type="nucleotide sequence ID" value="XM_011323966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RI27"/>
    <dbReference type="FunCoup" id="I1RI27">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RI27"/>
    <dbReference type="EnsemblFungi" id="CEF78257">
        <property type="protein sequence ID" value="CEF78257"/>
        <property type="gene ID" value="FGRRES_03448"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03448"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12911"/>
    <dbReference type="eggNOG" id="ENOG502QT50">
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    <dbReference type="HOGENOM" id="CLU_079101_0_0_1"/>
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        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Hypoxia_induced_domain"/>
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        <property type="entry name" value="Rcf2"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322104.1">
        <property type="nucleotide sequence ID" value="XM_011323802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RIG8"/>
    <dbReference type="EnsemblFungi" id="CEF78432">
        <property type="protein sequence ID" value="CEF78432"/>
        <property type="gene ID" value="FGRRES_03600"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03600"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13257"/>
    <dbReference type="eggNOG" id="ENOG502SYVI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091421_0_0_1"/>
    <dbReference type="InParanoid" id="I1RIG8"/>
    <dbReference type="OrthoDB" id="5383526at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124291" evidence="1">
        <location>
            <begin position="17"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF78432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="182" mass="18793" checksum="317E694583E56600" modified="2012-06-13" version="1">MYFSAILLTLAATASAVDVRAYSNSGCNGGWVGCAGINPGVCCVFSNSASSGRLSVSVNAIPSSWRIRGEANTGGGCTYLANQQDSNGNTDICMTYSSRGDRTGGSYSFVGRKRAADNSCPAEQPDGGKCEAGVKPDLLGLSDGTVYNIADLSDEKVEELEKIANTGAGADAVPAEFEPLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJI8</accession>
    <name>I1RJI8_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
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    <gene>
        <name evidence="3" type="primary">FG04009.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T14245</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321647.1">
        <property type="nucleotide sequence ID" value="XM_011323345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJI8"/>
    <dbReference type="STRING" id="229533.I1RJI8"/>
    <dbReference type="EnsemblFungi" id="CEF78925">
        <property type="protein sequence ID" value="CEF78925"/>
        <property type="gene ID" value="FGRRES_04009"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04009"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14245"/>
    <dbReference type="eggNOG" id="ENOG502RFUI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_773986_0_0_1"/>
    <dbReference type="InParanoid" id="I1RJI8"/>
    <dbReference type="OrthoDB" id="3594103at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF78925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="358" mass="38949" checksum="6485E66FFA99FDFD" modified="2012-06-13" version="1">MTSDNKSPTNNASADIDSCRIYFQGQGPCLVTRTAINRCPILAARIAAKPFFSNSRDTIDVKEIPYDVGAAVIYFLDTGKYRILDPKLDSHDERLCSDLGTAFRVYAAATMLELIGLKNAVNTAMANLEDMMDLGMVARSLKETGLNLEEYPTLAMHLYSYIQISEDVSSKEEMTSMIAKLGFPASVDIDSFQSCLVSKGSPVEEGNAKVVAASKPETTPEPSPEPKPAPEQSCSKDKNNTVTTIARSAPEEDLPETPASKTTATKMWTGLLPRVELAKAFRLKKAVPEGTIELEDRTMPVDEIMMPAQGLSEEFMVSARKLALSSVGQDSEEGDISLQEVAFQAPPPGQLYHGNFGY</sequence>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
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    <name>I1RJX5_GIBZE</name>
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        <submittedName>
            <fullName evidence="9">Chromosome 2, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321470.1">
        <property type="nucleotide sequence ID" value="XM_011323168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJX5"/>
    <dbReference type="EnsemblFungi" id="CEF79118">
        <property type="protein sequence ID" value="CEF79118"/>
        <property type="gene ID" value="FGRRES_04159"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04159"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14631"/>
    <dbReference type="eggNOG" id="ENOG502SMK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_25_4_1"/>
    <dbReference type="InParanoid" id="I1RJX5"/>
    <dbReference type="OrthoDB" id="3934549at2759"/>
    <dbReference type="PHI-base" id="PHI:5870"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    </feature>
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            <begin position="44"/>
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            <end position="363"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF79118.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF79118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="382" mass="42514" checksum="5D47C8E4FCC187F5" modified="2012-06-13" version="1">MRNPPLEVVATWPKPNHVNPEHRGPALLIVEISIMSVAILTLMARLYVRIFKVNKHGLDDWLMLAAMIFGIGVTVCVILAAQLYGWNIHVWDLTKTQAETGRQVSLAAQTLFLFSSGLAKNSILVSYLRIAPARSWLRRLTYASIVIVTSLIFAFLIVLWTQCRPTSAYWALTGGDSCHPEGPGVLSQAITTVLTDLLVCALPLQTLFQLKLPLSQRIALIVVFSLGLVVVFAASMRAYYTHWVTDETYDVTWEGFHLWIWTAVEANLGVICGSVPALRPLFRNIFRSKSSSYYNNTQSNVYPPGTAPGVVTVITSPKKNSRNWSNSLQKGSKGVRLDDDDIDVEGGYHNNTTRQKSTDSGVSSLEMDTWPQRPQPKSWPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1RKR0</accession>
    <accession>A0A098DM42</accession>
    <name>I1RKR0_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
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    <gene>
        <name evidence="4" type="primary">FG04475.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T15391</name>
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    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321122.1">
        <property type="nucleotide sequence ID" value="XM_011322820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RKR0"/>
    <dbReference type="EnsemblFungi" id="CEF79497">
        <property type="protein sequence ID" value="CEF79497"/>
        <property type="gene ID" value="FGRRES_04475"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04475"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15391"/>
    <dbReference type="eggNOG" id="ENOG502TECI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120091_0_0_1"/>
    <dbReference type="InParanoid" id="I1RKR0"/>
    <dbReference type="OrthoDB" id="3542181at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF79497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="196" mass="22070" checksum="C8C2AF4BEF52C99B" modified="2012-06-13" version="1">MQRNNPPSPPKTTQEPPPKSPNLVSHERYEMSRPLAIVAWFNVVGEFVRIHNNIYVAIMLPFHYFIFTLLTIVGLSFSLPTQTLEAQPAPTLSHALPDTTSMPDPLEERQERNNANPSVFNPPVTAAPDQAEKLESMGWRQTTYYECRTRGGQERCGWHIPVYKAAAEGRRGEIVGWKVVVGIALGLAMLLYGGWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I1RKS1</accession>
    <name>I1RKS1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG04487.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T15419</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321108.1">
        <property type="nucleotide sequence ID" value="XM_011322806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RKS1"/>
    <dbReference type="FunCoup" id="I1RKS1">
        <property type="interactions" value="794"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF79511">
        <property type="protein sequence ID" value="CEF79511"/>
        <property type="gene ID" value="FGRRES_04487"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04487"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15419"/>
    <dbReference type="eggNOG" id="KOG0569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_1"/>
    <dbReference type="InParanoid" id="I1RKS1"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="16"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="252"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF79511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="505" mass="53708" checksum="39C1845FB235A65C" modified="2012-06-13" version="1">MAGSRLRDISGYLILLIAITTLGSLQFGFHLAELNAPQDVITCQKKSINALSALDKIKGLIHKKPVEEDHGFLPHCIPMDEAAFATVSSIFTLGGLLGALTSGPFSSKRGRLPAMRITGLLYLFGAAVETVAGSVFVMALGRLFSGIGAGASTVVVPLYISEIAPPKERGLFGFMTQISINVGILAVQTLGYFLSYGTAWRWILGSGVFIATAQTLGLFVVPESPSWLAAQGDGTKAKRTLQRIRGNGYDINEETESWNGEERDASEEDGLLQADSASESAPKNRVEHLGFLQVLQDSDTRPAIIAVVGIMFVQQLCGVNSIIMYSVSLLADLLPISSALLTILISVVNLATTVACAPLPDRLGRKTCLLASIVGQGTSAFILALSIVFGAKIISAVAVVAFVGFFAVGLGPVPFLLASELVGQEAVGATQSWCLAANYVATFLVAQFFPIVNTALNNVLGGHGWVYFIFAGLAVGSFIFVFWKVPETKGKKDVDEVWGRTRRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RKS7</accession>
    <accession>A0A098DNJ3</accession>
    <name>I1RKS7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG04494.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T15439</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321099.1">
        <property type="nucleotide sequence ID" value="XM_011322797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RKS7"/>
    <dbReference type="EnsemblFungi" id="CEF79521">
        <property type="protein sequence ID" value="CEF79521"/>
        <property type="gene ID" value="FGRRES_04494"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04494"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15439"/>
    <dbReference type="eggNOG" id="ENOG502SS53">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_647303_0_0_1"/>
    <dbReference type="InParanoid" id="I1RKS7"/>
    <dbReference type="OrthoDB" id="4770905at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF79521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="453" mass="52187" checksum="1EC433616F030500" modified="2012-06-13" version="1">MASYYPEGECYFVRSSLRLPNGWNAENRNHFYSHFLIEYYWNGWVTTGSQSRHHTRSQWRHGTPSGLNNTRYGDWDRFWVGESKTNNPANMTAIHSHPNSLNWNECRDLNGGGPRKYILRPIQIQSDDAEWLWIDATIPLRAIYFPVAHTSDEAFPNMCTYVVIDFRHRDTTLITDYLGGFATWYPTTSHGGLGRRDNVTWGFHMPDIIAYLTIPHKLRNPDYRLFHSKRWSDDLVVSATSSIHWRSNAAVLHHPHFFRQIDFADVLSATFGVEVGWRPYEPSRFLRDLLISLVDLGLGFIPGVGPILSVAFGIAVQLLEDPESFSHENILNINQTAMDELTRSSRKHRKYLAPDFMGKGRGRQALVPLSDDERASRQKYGEELNQKLTKELNPQVVIRSLLDQELLLYGAVSLNGVVEEEEQTELETVSAEEEEEEKEKEEKEGDVESKKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RLE5</accession>
    <accession>A0A098E3W1</accession>
    <name>I1RLE5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG04741.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T16209</name>
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    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323182.1">
        <property type="nucleotide sequence ID" value="XM_011324880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RLE5"/>
    <dbReference type="EnsemblFungi" id="CEF87763">
        <property type="protein sequence ID" value="CEF87763"/>
        <property type="gene ID" value="FGRRES_04741"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04741"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16209"/>
    <dbReference type="eggNOG" id="ENOG502T47V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150781_0_0_1"/>
    <dbReference type="InParanoid" id="I1RLE5"/>
    <dbReference type="OrthoDB" id="3679184at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124321" evidence="2">
        <location>
            <begin position="19"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF87763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="145" mass="15054" checksum="D0894B84EB03A2E9" modified="2012-06-13" version="1">MKFSAAILAAAAATGATADAVLNVRDFAASCTPHSAMCSYSFNVIQPGTMDTKGYECTAKLPGAGPGELPEVKVGTCLPSSRTFDVVRSDKGLTLTVSVQVSPNSFTKGSHLIPTKDIKTVKGDTPTGDAQAYVGPKDFPLERVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1RLV1</accession>
    <name>I1RLV1_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG04920.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T16643</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
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    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
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    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </evidence>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
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    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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        <property type="protein sequence ID" value="CEF88362"/>
        <property type="gene ID" value="FGRRES_05188"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="766"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="783"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="831"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF88362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1162" mass="126488" checksum="00F190CB8C1CB8B7" modified="2012-06-13" version="1">MTESQSLQAGSNESQDSQAIIEAYRAEFGVGRFNSSLSKFTSSSRAGTEAPVLIPSPTSEVVVPSSDPTINENVASEVAASHDALTDTARSARPASESGDPSHWDETGVALTHSKKQCTLKTSIQRGVIQGREDRVNLITDRSKTPGHDILTNPQDLSNLPARHDSAKPQAVQNDAHKPLIGSTKPPNSAAVGALQNMDFSQQTPTQANFDRDYSEFCDIVPSSPVEVDTQSGSLEPRPLQDDDTGAVNFANLSEFGRPSSQVSEDAGFENTRGDWRRPDDTSQLNNGQTPHRPNAPTFETPAVPKNPFAAKPNIVAPLAGSQLFGQTQFSSAVKRISPTSSRPSPKLFDSKSANLIETSPLKNRANVSSPTDIRTSSPLRLHEIPDTLLTDNYEDPTRAQTPLNSRSASGDMIPESPPSAESTPRAQAPRSSGTTEPMSHYEPMQKSQERKILGSIVISPMNSDDDSDDAIRRMERRKRIERKKAKAAEELGRVSFTPKIWQDSTGQPSRKKRKLLSENNPEASHAKPKVNTDINKRQELPAIVDDSQKGLVASNELPVASTKATPGNSAPENQKVDQDGDTVLVDADKVAMDEDMIPATSPAPSLPPTAPVEYPEPSEPELPRLRMDDEDVPEGSNNHSESSSLPPPRRRTARTYGRAVQQKRRNPFLSSSNSDGLIGETEPRPMSMSSPLHKATGVSMIEEESEQEFQPPQETIKVETARPKKTARNVYADLPPPMTTRSRRNDRAGPTPVTPLASRSAGQILPTSSSLSVLSTTPTCSAKTTPGTQDSPGSERTESVALPSPGANRSLRNENIRSGAKSESPQQTGKSRRISKRYPRLGSESTDELHHSPAASVLERSIVHKSSRSFKQSFASVSRTGRLFDGMVFALSFSTQFKAQERKKIESKITQSGGAILTDGFQDMFEHSSIMSTMSPVMDEEEALRLTKTSCESGFTALIADNHSRKVKYMQALALGLPCLAPQWITACLNKGAIVDWEPYLLCAGASTVLGNALRSRILAPYSATEARLAEVIEQRPRLLDGQRVLVVVNAKKSRNEAKEPYIFLASVLGPSISRVFSTQQARELLLEHQKAGNPFDWLYLDKGTGTVEAVLAPSETTGNKRRRKSAPAQSKTVDIRVLDDELVIQSLILGRMVEDNEMYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I1RNE4</accession>
    <accession>A0A098DZY9</accession>
    <name>I1RNE4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG05518.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T18113</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324065.1">
        <property type="nucleotide sequence ID" value="XM_011325763.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I1RNE4">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RNE4"/>
    <dbReference type="EnsemblFungi" id="CEF87426">
        <property type="protein sequence ID" value="CEF87426"/>
        <property type="gene ID" value="FGRRES_05518"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05518"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18113"/>
    <dbReference type="eggNOG" id="KOG1835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002778_0_0_1"/>
    <dbReference type="InParanoid" id="I1RNE4"/>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF87426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1664" mass="186854" checksum="9604CFCB7E518AD6" modified="2012-06-13" version="1">MAEITALDALQAFHQGLLSLREGRVEGAETLGNEFLVQVFETELAKFWDKPARKSDNRNAVKSGKVVIDGDEYSINDNFQQDVLTFSDEVELDELESTRCLLESQEDPNTLGRSLLECAIIRFHQQRKYVLDIVRLLLELEGLDDDIADAEALESVKLYVAERLLQPSMGADTTKRIVPRCMASMREIKAWLQKIGDKIAAAQTLGQTTTNGVSEQIETIEFSRVSLMQQHELLGVILCRSIEMRQGSTQDFLDFVSVLQKVDRYDALLVHLVPSIGAYISVFGSAEGGYDLIKARELHGKLFPTDSSPWPLSQLQAAFRAWWLAEYSGFYVDDPPEAAIPPNTDLDEEDRQRSKAFLESLKDGSFDFLLSIAADVKSPDWHDPVRAGMRKWLQRKSPALAPDAIPFADFFQMSLMLQLEVFVDGFISNLPDVLRKLRVEEDEQRQSSQTHEQDLDLERFLLIIAYAYEGRPDAAMNFWSDPDSNLAGFMHWASRRASTPLVTAFCEMLQAISENEECASAAHEFLIDEGHHSSGKMRKSQSLTWAQIFKELDFFSAKIRQKPAPPQAIRYRNEKMSSDQAETEPESAMMLECYLRLMSKLASESETTRQFLLQNPNYSLVETLLELASSNIPPRLRGCTFMALRALMARKSLQEGALMWNCLDQWITGEYFLHPVTSHRQSQQSPSVFMERIFDEISNGFEDPESFIQLLLSLISPAADSSPLNDGLPFPENLGSSSRMPGIEIYVDFVIGLVFAQKANDLQDVNQTRVLRLSCLEFILICLNTFNEDLIIMANETNINVDSVIATTDLATYVRMHPFARVMEWMFNDKVMAALFNTIHQEPADVGNASPDSPLILGILRAVEVISKVLDLQATYLELVRPIIKLQSNQRRPPVANAAFASFEDGLVTRLNLVVDLGNYCGIGHPELTLACLKLLEKMSSSSKITAVWSGSSRQMHRNKAIVALEANGEHETISRSFVSELITPLETGRETDSPAYVTKIYILDFLYQCLQETPRKPTIAHLLLGFKCGIDSLSVEAKGAFTSRTSLFHTILRLLLETPSGDAQGMRQWLIAIKSRVMRILHILWSSPLSAPVVVEELRENEILFHLLLRETVINPDLPWEGENVALVQFPVTDGAIALIDFLSLRSMSLEYIAMELCSIAQNRMPSVKRRIFEALNGQIIGEGDTPIPIPTIFDLYDFLLPEGVWEIPLPPLQYYKDLDLTACLENDTDGNQIYNLERVKEVLLLKRGEAHDAGTLVAAQDLVAFEREESMIIEYLISSNRQKQLTTQSLKVLKTWTKLLLVMIESNDFKGSAQISFFLQALQSILPSLEAFASERPDEAFELAKLSKILLFKLDLSASADDKQGSAIGNLISDKLFQLFQICLQAIGKWAGTPELRSIYYSICYRYLTGMADQGPLTSNRPKTIKTIQVYGERLLNVICDDAYGGEAQCQTAALILLNALISMGHQESEGYVVETLNRLNFIGIMVDSLRNIMQEWQEVFTSGTSEQQNYQNARLALLLELAQTRSGAKYILHSNLFRALEISGLFGADPELQINSTNPRALEQHYDLLAQVVRIVSAALVARGSHNVVQGRRFLTDHRMLVTHTLKRSAGIGSANADEGLDQKIEELAEGLMVIIAATRFLEFENEGLPESTQQSHGLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1RNU9</accession>
    <accession>A0A098E3N6</accession>
    <name>I1RNU9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG05691.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T18523</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324265.1">
        <property type="nucleotide sequence ID" value="XM_011325963.1"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF88239">
        <property type="protein sequence ID" value="CEF88239"/>
        <property type="gene ID" value="FGRRES_05691"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05691"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18523"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001569_0_1_1"/>
    <dbReference type="InParanoid" id="I1RNU9"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="926"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1413"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF88239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1845" mass="200180" checksum="7D7ABE23D9C2304B" modified="2012-06-13" version="1">MNSSTVNARQRRIIQLSQQWGFSLPPNAPAPLSRPAHPTSFRTHGDDEVAEGLLHRRSAEVAQLRPKSGLSRAFSSSNLKKGKHWDTKEILNVLNSWVDSSGSPGVAEALIAKLAAAGVDLSGMQTQKQGLLNRRKSVENGLDRTRLLKSAIERDQHDMVHVLIPHADPLTLDSCLPPAVRTRNPRIVETLLRYGASASATAEGQDEFRKACAIPALSEIASLILRSDGRPSEICVSQALTDASRAQCFDTVLHLSRSTADCNYNNAEALKIAINNERRDIAMAIATGNKPPQNPGLAEAFQQLMENTNMNPKSKLDFAELLLCCGAQGPILERSLEMACDSQFFEMADLLARYGASIEHNDASALKAAISKGQVNLVSSLLNGSSKIDPALASSCVPLIPQQADPGMRQALLYSLLKTGANGPVLNDCLIHAAKAGDLQSVELLLNPHFREPPSEQPNGHGKPRISNRHAVASPDHQDGEALRYAISAGNADLAAKILTARPSNETLTAIFPLVKSLPSSERYRMIELFLRGALTGPALHIALQDAISEDPSQRDDALISLLLKYGADINYDEGVGLHNVITQMDLGLFNTLMQSASPQTAAARLADVMKIENRQVRYEMMSVLFKARASVGVQQVAEALLITLEERSVDMPLLRLILQQGKADINGCKGQILQRATQSPDHKVLELILGLGKHGPDTIPNCIDSLGALSPTDSKAWKLGVIIAKSPKKINLDNLLVQEVQAIVQDETGQASFAMLNKLLDSGADPNNYKARALCSAVGAARETVVDVLMVCQKPPTSASLAAALPQALKIPDPMNRLTFTKTIVEARAPPQEVNRALIHAINNFISDIALIGVLAGFADASDGEALALAVSKEAPEILDLLLSRVKHSSESRDSCLEKAMKITDWTCRLQICKRLAKAGITPQAASNALLVAARDGDLELGDVLIAYGASISTNDGQAIIEACRGGSVEVLDVLLKSNADTEKSTLGRGFQAATEVGDLNKRAMIFQRLLKRGVSGDVVNIQLVSAAKSGENGHEVLRVLLAAGADPNFNNGEAVFAATRSAFVSGLELLLGLWHEGGNQKKASPPTLIRALKACWKLNPDTRLDIIKDLFRAGIPIVEEVHMALSRAVGEDEPDERLIKVLLDSGASPLMNGCCALTRAVQGAKVSSVELILTCEFAEDDILTAFSSGFSDALFTTWFSANGLAVAKMLLATGAKGESVSCALVQVMKGSTDETESLADAFVELFVSYGANVDFEDGQPLVCAASKGNAFWTERLLSCKPSPRTLTLAFERVFDTARSPDEVLKLFELFSGYRDGEVGLDVMTRTAGSDPILVRAISQYPRSAELLQVLLDAGFYHDQTTTCHIHESVDEPEEVTVLLWAIAQPQKKVSSALIKMLIERGANVNFETAVSRSTPLMLAIQARRPDIVKELLIEGANVDITDAMGRTPLAMATDIGGDLSTRMMGNLLAIDQSKDDGSLHNAARELNLAAVTVLVEHGHHPDFPSPLHDGRSALGEVCLRGAGACSGKLTADGEKLMQKVMTFLIDSGSDISLQSHGKSALLLCFESSDPIATTRSFLKVAMWKEINRPFNQYSDGDFTYSPTMYVKKVMPESDTRDQLLTLLRANRAVDVYYANSGDQPEDAIGLPSDMLVQERERKARLRRLALETEDHAIALARAKEVASVEREIWNNKAEIEDARRRRLYSEDINAARQKADLEESLFNAALKRRLSEQHKLTQSSLERTKLIAAAEITAEETRQQKMLEWESTMNSERASNAQALSSLRISEREELDRIERGADDRIKKRLEAQKKLVETQERLAKRIGNVPGGPDARRQIGYVEEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RPC0</accession>
    <name>I1RPC0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG05882.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T18989</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324487.1">
        <property type="nucleotide sequence ID" value="XM_011326185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RPC0"/>
    <dbReference type="EnsemblFungi" id="CEF86868">
        <property type="protein sequence ID" value="CEF86868"/>
        <property type="gene ID" value="FGRRES_05882"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05882"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18989"/>
    <dbReference type="eggNOG" id="ENOG502QPK1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_1_1"/>
    <dbReference type="InParanoid" id="I1RPC0"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000395">
        <property type="entry name" value="Carboxylic acid transporter protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000465">
        <property type="entry name" value="Carboxylic acid transporter protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF9">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORT PROTEIN (AFU_ORTHOLOGUE AFUA_2G09450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="72"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="487"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF86868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="516" mass="56625" checksum="95D13789F5F58ABF" modified="2012-06-13" version="1">MVQQPMAGESAGPVVKGVVPTAKQAFADLFIWKQRVVVTNEHGEETTEWRDPDPIQNPISLMAQLSAKDWIFFLVGFCAWTADAFDFHALSIQTKKLSLYYDTSKTAITTAITLTLLLRSVGAAMFGLAGDKWGRKWPMVFNMIILGILQIATIYSTTFNQFLAVRSLFGLFMGGVYGNAIAMALESCPSNARGLMSGILQQGYSFGYVLAACANLGVGGSTESWKTVFWIAAGISIAVGIVRIFFPESQQFLEARAKGKQSASPGAFWQDCKKMLLAEWKMCVYCCFLMTWFNYYSHTSQDSYTTFMLEQKEFKNEAASRASILMKTGACVGGTIIGYLSQFVGRRRAICISALMSALMIPAWILPTTEGGLSASGFMIQFFIQGAWGVIPIHLNELSPPAFRSSFPGVTYQIGNMISSPSAQIVNAVAEKTFVTLKNGDKVEAYGPVMGVATAIIAMGIIFTTMFGPEKRGRSFEHAVAGVRNDELPHHQKKDIETASVEQVEMDERKKAKEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RPC6</accession>
    <name>I1RPC6_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG05888.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T19007</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a key role in the late stages of endoplasmic reticulum to Golgi traffic.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324494.1">
        <property type="nucleotide sequence ID" value="XM_011326192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RPC6"/>
    <dbReference type="FunCoup" id="I1RPC6">
        <property type="interactions" value="373"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RPC6"/>
    <dbReference type="EnsemblFungi" id="CEF88026">
        <property type="protein sequence ID" value="CEF88026"/>
        <property type="gene ID" value="FGRRES_05888"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05888"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19007"/>
    <dbReference type="eggNOG" id="KOG3315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073154_2_1_1"/>
    <dbReference type="InParanoid" id="I1RPC6"/>
    <dbReference type="OrthoDB" id="10254842at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000007">
        <property type="entry name" value="Trafficking protein particle complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF88026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="220" mass="24658" checksum="CB319B7F2A26CD30" modified="2012-06-13" version="1">MSNLQPPNAGPVPAPSPNGKDGLRYPSNGKTIYHRPLNRTKTAELSQASFAYLFGEMVTYAQKRVKGIQELEQRLNLQGHSIGLKLLDLLLFREPVRTQTRPLGIIQLLHFIKQNIWQHLFGRQADRLEKSANPETPDEYHIIDNEPLVNQYISVPKEMSQLNCAAFVAGVVEGVCDGADFPARVTAHTVGEGDMWPGKTVFLVKFRPEVLEREGFLGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I1RPY0</accession>
    <name>I1RPY0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG06112.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T19511</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324736.1">
        <property type="nucleotide sequence ID" value="XM_011326434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RPY0"/>
    <dbReference type="FunCoup" id="I1RPY0">
        <property type="interactions" value="475"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RPY0"/>
    <dbReference type="EnsemblFungi" id="CEF86371">
        <property type="protein sequence ID" value="CEF86371"/>
        <property type="gene ID" value="FGRRES_06112"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06112"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19511"/>
    <dbReference type="eggNOG" id="KOG3309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082632_0_1_1"/>
    <dbReference type="InParanoid" id="I1RPY0"/>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF65">
        <property type="entry name" value="FERREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="77"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF86371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="189" mass="20788" checksum="AFCD9E37BE89E449" modified="2012-06-13" version="1">MSASRSFATCLAKLPATACRTTQPMRFSQNIMSQASRSQFAVIPRAVRFSPVSQRAFTTSTQRRHGHIDPPKPGEELYVTFIEKDGTENKFAVSEGDNLLDIAQANDLEMEGACGGSCACSTCHVIVADDEYFDKMPEPEDDENDMLDLAFGLTETSRLGCQVKMTKEMDGLVVKLPSMTRNLQASDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQ29</accession>
    <name>I1RQ29_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG06163.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T19647</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324798.1">
        <property type="nucleotide sequence ID" value="XM_011326496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQ29"/>
    <dbReference type="STRING" id="229533.I1RQ29"/>
    <dbReference type="EnsemblFungi" id="CEF88243">
        <property type="protein sequence ID" value="CEF88243"/>
        <property type="gene ID" value="FGRRES_06163"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06163"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19647"/>
    <dbReference type="eggNOG" id="KOG4144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061829_0_1_1"/>
    <dbReference type="InParanoid" id="I1RQ29"/>
    <dbReference type="OrthoDB" id="30840at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051635">
        <property type="entry name" value="SNAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908:SF0">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="193"/>
            <end position="266"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF88243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="307" mass="34064" checksum="3A23AC9A6199B321" modified="2012-06-13" version="1">MGSMDVKNEFASAARDIIFSGGVTDSREKKEDEDDGAITDGDADDDMVNTKRNFSAMRIQKRNSEAGLLKKVIPFHWAPMLQPLTENDIDTCVTLEEVALSETYRSPREKIEYRIRNGICYGLFNTVRPTDVKKISLSTMQHSRPVEGGRCDGAKHVMFAHVLATLGTHSVITDADMAMPENWRDAKVSKGSPLGHQSSGRTICLHSFIVCPEVQGVGIGKTVMKSYLELMNESGVADRVAIICQPYAIQFYKCFAFKDLGPSTEALAGQGYHAMVLELRGPKRKTKEEPTRKNKEDSKDTKPKKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQU1</accession>
    <accession>A0A098DPW3</accession>
    <name>I1RQU1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG06441.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T22285</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF82913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326039.1">
        <property type="nucleotide sequence ID" value="XM_011327737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQU1"/>
    <dbReference type="FunCoup" id="I1RQU1">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF82913">
        <property type="protein sequence ID" value="CEF82913"/>
        <property type="gene ID" value="FGRRES_16658_M"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06441"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22285"/>
    <dbReference type="eggNOG" id="ENOG502QURG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_3_1_1"/>
    <dbReference type="InParanoid" id="I1RQU1"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF35">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF82913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF82913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="290" mass="32907" checksum="4150321421757F25" modified="2012-06-13" version="1">MMHSHGRGRAYIWQIIEAYRCTLSRGDRKQIPFKEKRKGLSLNLHVYQVVTTRVWFFLPFLLGSLFEATAFISRAISAKEAPNYTLGLCMVQDHLLLLGPTCYSAAIYMLLGRFIRYLDGDKFALIKPKWLTKIFLFGDITSIVLQAFDGGANDKTDSSHNLTATEDVVVAGLIVQLVFFSMFVIVAGCFHYRFSKNSVVQPPNWQKFMMVIYFASMLILIRSVFRMVEYVEGPQSKLQAVEVYVYAMDAIPMAIITISFHIIHPSNYMRGLGKTLSKTDSETSLASPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RRQ9</accession>
    <name>I1RRQ9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG06794.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T23203</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
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    <dbReference type="EnsemblFungi" id="CEF85411">
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            <dbReference type="EMBL" id="CEF85411.1"/>
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            <dbReference type="EnsemblFungi" id="CEF85411"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000070720"/>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23693"/>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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        </location>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
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        </location>
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            <begin position="1509"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
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        <source>
            <dbReference type="EMBL" id="CEF83612.1"/>
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    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1526" mass="166352" checksum="B53BA6C5D472E24D" modified="2012-06-13" version="1">MLSPSFPSASPSSNDNARRKTRRRPHTELNINTNTSSLASPSPRERDSIPLPRTPPPKDSEYRRSKSKSRHQNTNNREPSRPPISNLYAHESFLENPTPVEDDMDRRLPPSNNRDSHDLSLSPRNVTRDSLVANMLLSLDQFSMAQLSDKYGPSTSTPGSRSHTFDETSSQSIAAEQTRSWVASNSVAAPSRPNGHQYSYSSDLEGADDSSRISSRGRRSNSSSNFQSSFPRLNSVREGHRAGSSRAMHSRGGKPGSRNSSVTSVDAGYAQVLGSQRYGRGFARSASFDYGPQQQSSPAPAPVIEPSSFRVDFPNSYIDDEYDAAPTPNVPGGPRRQPSIPTMSKAASMPPPIPAAPLEPPTLDHKRSSRSLKSSSGRKAAASREPTPAVPALDLDSAPAPNVGYGKSKEAVHSGPTTSHAAAPVKERPGFFRRVFGSSRNNSQNTSESANTPAPQLNSTADTKVAGNASTPPSRDTSSSHSHHPALQKKPSSFFRRRKKSVTEETPPIPAMPMAPVPTTAVPSLAPQERDSSLPQQPSPASSLRKVMNPYIRTGQGAPGTSTSQGPSPLADISNMTPERNVDQEEYKRGFSPDYSPSPNARITTVRSESNEQLSKRNQIDGTPSRLPSERPTKTMESRNNSFLNLDGLSDNEDDNGMFGFNLASMSNTKPQQSENRDKSGRGHSRDPHRLEQSDSEDELDHANLALPIEGARASSPGSASTGTDYKSALSAAPSVRIESSADPSPKVLGTFDSIKNKGIDEPEFVIGDPTEDDRQKAQKIYDGNEDFIQKGKAASFMGEEGPIRQRTLQAYMELYNFTNQSIVQALRQVCGRLVFRAETQQVDRILVAFSKRWCDCNPNHGFKATDVIHTICYSIMLLNTDLHMADIEHKMTRSQFIKNTMGTILQAVDEAAPDAFQRASILPDKNGFPNGENQQPSEQDKRSFRNSFRPPARADSGTLPGEGIEDCGPLVKSRFSGTRKAWEEQIETVLKGIYNSIRDERLPLFGAESEKNASLQPSNSGGLSVMGMLKRSPSVLSKAPSESQLSVRGRINDNGKANSARWTSKSRSRAGMSRTGFSSSRTSFDDGNSLWSPTASSATWSRHSLGRTQTSVSQDSFGSALRGDYQQSIGFANALSQAIIRDEEVYGDGAPSIMSSDIPATQLLEDESLELAGPPWVKEGMVTHKHHLDGVDKKAKARNWSEVFAVIQKGQLNLFSFQPNKSVRAKNRDRNNRGGPVLVGGGNWQDNATNLGSYNLRQTLASALPPPGYSRARPHVWALSLPNGAVHLFQVGTPEICKEFVTTANYWSARLSTHPLTGGISNIEYGWSEAIVNNALVSIINETAPGKTSRPGSSAAQHHHRRSSANSGSFRGSSFDQVAGAFTNNSGRGKLPGDRIHIAEWAPPTQSMRPSNQPEAAQLQTLDAYVKGIEAELQTHNRLRSPMLLAFTPRGSNAVKAMANWERKSAYLLREIVKFTTYVDCLQQAETRKQEIYHERDLAQRAARGELSDGDMDVSGDEGDVTLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>I1RTB2</accession>
    <accession>A0A098DMR1</accession>
    <name>I1RTB2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG07413.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T24761</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327182.1">
        <property type="nucleotide sequence ID" value="XM_011328880.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I1RTB2">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RTB2"/>
    <dbReference type="EnsemblFungi" id="CEF83146">
        <property type="protein sequence ID" value="CEF83146"/>
        <property type="gene ID" value="FGRRES_07413"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07413"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24761"/>
    <dbReference type="eggNOG" id="KOG0298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001592_2_0_1"/>
    <dbReference type="InParanoid" id="I1RTB2"/>
    <dbReference type="OrthoDB" id="5330228at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18070">
        <property type="entry name" value="DEXQc_SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000059">
        <property type="entry name" value="SNF2 family helicase/ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059033">
        <property type="entry name" value="C144_05_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26021">
        <property type="entry name" value="Ferritin_C144_05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="313"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="1098"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="1213"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="714"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1160"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="726"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1160"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF83146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1422" mass="161571" checksum="32F715D5F4FAEE41" modified="2012-06-13" version="1">MARAKPTARRRASPSRVHLQVGTDDLIPAPLVERFVKIATSENESSPQSPEPPTKRRKLDTSILVAKAKLTVTRQCTASSQTSVSCKGVEKLMSVHLRDTRLSFFSSEGCPVDPFRATINLRRLETDNHLQILSNLFQSSKLSRPNELWTTVDMKLEWRGRQVKMSFSYNFYWNDSPSLDSHHRPAADRKESQKLINFILRGSPSTGPPLWSGWSPMDFYDAAFVPPKDDKVAESIHIAAMKSTLFPYQKRTLQWLLQREGVQWSESNGGLVPYIASDREAVYDFEKFADLNGEEYYLSETLHTATRDLALFREAEASTKGGILAEEMGLGKTLEVIGLIMLHARSRPLVQSTDEAQAKLTPTGATLIVTPPSLRDQWVSEISRHAPSLSVEVYEGRKKISDDDEEHIINELAGHDIVITTYSVLSSEVHYTIAPPERSRRHARVYQRPISPLTQISWWRICLDEAQMIENGYSQAAKVARVIPRVNAWGITGTPVKNSVEDLQGLLLFLQYEPYCYTKSDWDHLRWNKSGFQRLFNKITLRHTKSMVRNELVLPSQKRFVISMPFTAVEEQHYQSLYRDMAEACALSLDGEPLVEDWKPGDHAANMRTWLVRLRQTALHPEVGSYNRRILGHNKNRPMRTVEEVLDAMLEQSESAIRVDERAYLSSQLTRGQLYENSPRVKEALEIWKSVREKTRELVSEARAELQALLMDRGGGGSAAANADDLGMESEDDEEVEGKGQLNESRRRLRSALEMEHRAVFFCANAYFQIRENPVMVEPDSEQFYQMKKLEDDGYEEAKVIRREILRESHRRATRSMTKLAQKASEQSFVEIPDLTVSDERGIESRRIIDDLETLCGELNDQANLIDEWREHIIGLLLKPLVDEEGDAETTGEEYGESAEIQDELMVYVQSLGAVIADRQDALTGQTNELVKHETRTSLRQAESGEGPAPEKLIELMMLRDQRKPNSTSMRSIISRFRALTSKVSKDTTRNILEGRIVDRQLRATQEAMNTQSKLALEAEVDNFKTIMNLRLEYYRQLQAVSDSVLPYEGPDVTDVIEKKMKKTEDDFRKKLSAAKAKHRYLQHLKEAGDNSNEPRMCVICQTPFTIGVLTVCGHQFCKECIKLWFKSHHNCPVCKMELKPSNLHDITINPLQLKLHGDDSDQVHGGTEKNSQRKQSGLQRKTGIYSEFNTDKLAEIQNIKLDGPSFTTKVDTLVKHLMWLRESDPGAKSIVFSQYKGFLEILRNAFARFGIGHVSIDDSGGIRRFKEDASVECFLLHARAHSSGLNLVNASHVFLCEPLLNTALELQAIARVDRIGQTHETTVWLYLVSGTVEESIYNLSVQRRMEHMSRASKGKSKESTPELLDANIEAANTLELEQASLTHLMSKDKTAGENVEEDDLWQCLFGHVAREGNEPERDVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1RU80</accession>
    <accession>A0A098DRT0</accession>
    <name>I1RU80_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG07764.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T25595</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327579.1">
        <property type="nucleotide sequence ID" value="XM_011329277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RU80"/>
    <dbReference type="STRING" id="229533.I1RU80"/>
    <dbReference type="EnsemblFungi" id="CEF84077">
        <property type="protein sequence ID" value="CEF84077"/>
        <property type="gene ID" value="FGRRES_07764"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07764"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25595"/>
    <dbReference type="eggNOG" id="KOG4626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001305_5_2_1"/>
    <dbReference type="InParanoid" id="I1RU80"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="392"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF84077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="595" mass="66250" checksum="76C805EBA5D2D8A5" modified="2012-06-13" version="1">MGTLADLLYYRFNRTGGIFDLDKAIQMRKQIVRSTPKTQNGRPGYLNNLANLLLARNTRSGALSDLVEAIDLIRQGIKDTPKSNVYKGSMLATLAAILGTKAVQTSDDKDLDEAIDVAYQVVQVVPPAHPERVKYLHNLAKLLRMRYSRSMTAKDLKEAIKIAQEAVDTAPSDFPDRYSLLNILADLDQAYTVAKFTVELITLLNSRSIQNVDKQTLLMQAVAIASDAAAISLLHNRSTIDAVQLLETGRNIIASSLQDLRTDLSILQKEHQDRANRFVQLREQLDVPVTKNSPTENNNSGHPSREADRRRGAEEKLKVLKDIRAQSGFEDFLLAPSATDLLATARDGPIVIINVSQFGCHALIIQLSGASTVPLPSLFWDKIHRRDRGSLETLEWLWNAIVSPVLNAMSITQNRADRDLPHIWWIPTGRLVGFPLHAAGYHLDDGLKTALDRVVSSYTPSVKTLIHSRRQRGSKLQAQHFEQNLVLVAMESTPEQGHLDYAAEEIQSIRDVTKSSTKIIAKEPPTFKNDVLSALRSCSIFHFAGHGGTNSLNPLGSRLLLSDWKADPLSAENILDINLDREMPFLAYFFGLRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1RUW5</accession>
    <accession>A0A098DCV2</accession>
    <name>I1RUW5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG08023.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T08935</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320806.1">
        <property type="nucleotide sequence ID" value="XM_011322504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RUW5"/>
    <dbReference type="STRING" id="229533.I1RUW5"/>
    <dbReference type="EnsemblFungi" id="CEF76270">
        <property type="protein sequence ID" value="CEF76270"/>
        <property type="gene ID" value="FGRRES_08023"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08023"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08935"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="InParanoid" id="I1RUW5"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000047">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF76270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="502" mass="57045" checksum="AF07D777D45EFC5F" modified="2012-06-13" version="1">MAIISTDLASGTSLGGGLVLLAAAVVLFVTGRAIYYVFFHPLAKIPGPKLYAATQLPYLYHLTRGQWVYRLKELHEQYGPVVRYTYNDVSFITADAYKTIYGHKTGGAREFGKDFRLYRQGRPAPSLIVTKHEDHKRQRKLLSHAFSHKALSEQNDLLMHYVNLFIEKLTQKAREGESVDMVAWYNFATFDLIGHLALGQPFGCLESGKYHPWVTKIFSSIKGISFSQAAIRLGLHNWISLITPAHVKKATKEHFEFTEHVAGARLDVKDNNSKDFMSYILRYNDERGMSRPEIIENSSLLIVAGSETTATLLSGVTYQLLTNPEAYKKLVTEIRLAFATEEDITAAAVDKQTYLLAVLSEGFRMYPPVPGALGRTIPKGGDFVEGHWFPENVGVSVPQLPAYHSARNFKDPEKFVPERWMDDPRYSNDCRAVVQPFSMGPRDCIGKNLAYLEMRLLLTRLLWKFDAELMPESREWKEQKIFTLWEKGSLHVKLTEVVREKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1RUX7</accession>
    <accession>A0A098DBI7</accession>
    <name>I1RUX7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG08036.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T08971</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320788.1">
        <property type="nucleotide sequence ID" value="XM_011322486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RUX7"/>
    <dbReference type="EnsemblFungi" id="CEF76288">
        <property type="protein sequence ID" value="CEF76288"/>
        <property type="gene ID" value="FGRRES_08036"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08036"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08971"/>
    <dbReference type="eggNOG" id="ENOG502SS80">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1277717_0_0_1"/>
    <dbReference type="InParanoid" id="I1RUX7"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="58"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="216" mass="24691" checksum="96930E88847A7CE4" modified="2012-06-13" version="1">MSLIGGPELGYHADMKGFLAKLAGDAAPNKTNFSATSSSDSFVVESQLENVNWVELTNADLDELQKHVVPCHDDLEPRNILIKRDGTHSGKWHVAAVINWEMAGFFPFAYEYGHKDAQLGLSNLHFSYYAVFKEQSGHLLARVNQLSNYWRRSGRWMCQRRDSQQRMSAGGSNHGGWRGKRLSCHRMFDLDGSEKQMLEMFEYLRSKTTTILRWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RVK4</accession>
    <accession>A0A098DDQ4</accession>
    <name>I1RVK4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG08284.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T09559</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320511.1">
        <property type="nucleotide sequence ID" value="XM_011322209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RVK4"/>
    <dbReference type="STRING" id="229533.I1RVK4"/>
    <dbReference type="EnsemblFungi" id="CEF76582">
        <property type="protein sequence ID" value="CEF76582"/>
        <property type="gene ID" value="FGRRES_08284"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08284"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09559"/>
    <dbReference type="eggNOG" id="ENOG502SMKX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033726_0_1_1"/>
    <dbReference type="InParanoid" id="I1RVK4"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF1">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF76582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="291" mass="33187" checksum="C167FEFB0F13E690" modified="2012-06-13" version="1">MAFHESKAATMSCIEITRMPQLAEAIDKADNWTGTKDAAARRRAQTRLNMRAYRKRKAQEKKNHSTVIKQETTIDLWDIKQELISNVSSSNAKQLYNSRNPLMPWKTQNNQSNIIFPLCPDHLITLLQYNALRALSVNRSLISGVLCTPLECDQEIIHVVPYPSNPECIPAALLPTLLQQTVPHGDWIDLFPSPEGRDNLIHATGTFDEDDLWADCIGGLYEGYPDDEMEKRGMIAWSPPWDISGWEMSPGFVEKWGWLFKGLSGPMEATNRWRVERGEEPLVEMLEELHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1RWW6</accession>
    <name>I1RWW6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG08802.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T10857</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319918.1">
        <property type="nucleotide sequence ID" value="XM_011321616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RWW6"/>
    <dbReference type="FunCoup" id="I1RWW6">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF77231">
        <property type="protein sequence ID" value="CEF77231"/>
        <property type="gene ID" value="FGRRES_08802"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08802"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10857"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_0_1"/>
    <dbReference type="InParanoid" id="I1RWW6"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="60"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF77231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="453" mass="48653" checksum="495FB2BB83A2E071" modified="2012-06-13" version="1">MDCHQVTSRALYEEDDVINHVNQVDAENGDVKTGGDLEKHQTAASTASYQETYPEGGLQAWSVVAGSWFSLFASLGLMNTLGTFQAYVLDNQLTEYSEGTVGWIFSIYTFLAFFCGVYIGPVFDKYGPRWLVIAGAVFTVGGMIFMSFATQLWHFVVSFGLLCGFGSSLLFTPSIAAVGHYFKARRGLATGVASTAGGIGGIIYPFMLTRLIDKIGYGWATRVIALICLVCSLIGIALLKSRLPPAKDATAHPNFLIFKSLPFLFTTIGVFLLEFSLFIPLGYISTYALHKGFGKDFSYNLIPILNAGSVIGRLLPGYYADVIGPFNVSILAVILAIVACFCVWLPLGGTTAGVIVFAVLFGFSSGTSIAIAPVCIGRLCKTQEYGRYYATAYTIVSFACLIGIPIGGSVVQANGGEYWGLIILTGAIYVGSMISLFLAKVSLLGLHNWKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RX89</accession>
    <name>I1RX89_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG08943.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T11245</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319751.1">
        <property type="nucleotide sequence ID" value="XM_011321449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RX89"/>
    <dbReference type="STRING" id="229533.I1RX89"/>
    <dbReference type="EnsemblFungi" id="CEF77425">
        <property type="protein sequence ID" value="CEF77425"/>
        <property type="gene ID" value="FGRRES_08943"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08943"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11245"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="I1RX89"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000398">
        <property type="entry name" value="Probable 2-deoxy-D-gluconate 3-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF5">
        <property type="entry name" value="2-DEHYDRO-3-DEOXY-D-GLUCONATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="11"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF77425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="260" mass="27527" checksum="0D5B16D877745533" modified="2012-06-13" version="1">MSASFFSLQGQTALVTGGTRGIGQAVAIGLAEAGSDIILVQRDTTSQSTKESIEKLGRKAFIYTADLSSQESVAALVPKVLADGHEIRILINCAGIQRRHPCEVFPDSDFNEVIQVNLNSVFTLCRDVGAHMLNLEPSPVTGRRGSIINFGSLLTFQGGFTVPAYAASKGAVGQMTKSFANEWTAKGITVNAIAPGYIETDMNEALLNNPERLASITSRIPAGNWGSPDDFKGTSVYLASKASGYVSGHVLVVDGGWMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1RYB2</accession>
    <name>I1RYB2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG09354.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T27281</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF82915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328390.1">
        <property type="nucleotide sequence ID" value="XM_011330088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RYB2"/>
    <dbReference type="STRING" id="229533.I1RYB2"/>
    <dbReference type="EnsemblFungi" id="CEF82915">
        <property type="protein sequence ID" value="CEF82915"/>
        <property type="gene ID" value="FGRRES_09354"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09354"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27281"/>
    <dbReference type="eggNOG" id="ENOG502SHK1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027816_4_0_1"/>
    <dbReference type="InParanoid" id="I1RYB2"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="51"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF82915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF82915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1RYC5</accession>
    <name>I1RYC5_GIBZE</name>
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        <submittedName>
            <fullName evidence="9">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG09370.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T27249</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328375.1">
        <property type="nucleotide sequence ID" value="XM_011330073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RYC5"/>
    <dbReference type="EnsemblFungi" id="CEF83008">
        <property type="protein sequence ID" value="CEF83008"/>
        <property type="gene ID" value="FGRRES_09370"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09370"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27249"/>
    <dbReference type="eggNOG" id="ENOG502SMC3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_4_1"/>
    <dbReference type="InParanoid" id="I1RYC5"/>
    <dbReference type="OrthoDB" id="3936451at2759"/>
    <dbReference type="PHI-base" id="PHI:5819"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF96">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF83008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="391" mass="43443" checksum="210B03401A906890" modified="2012-06-13" version="1">MGIPNRGPELQAVCYTLLVSSVIAVALRIYVRTRMVKNFGLDDWTMCAALVTFLLFCTSSLSGVTHGTGRHRSDLDPIDYMKARNWWWWCYLWYCLTMITSKISIGITLLRITNRKMDIWILYGTMAITLCTGIVFFFVTLFQCWPISYFWNTNQEGKCVSPDVIIALTYLYSVFSVISDFTCAILPIFLISKLNMGKKTKLAVIPLFAMACVASSAVVVRFAFVKDFKNPDFLWATVDIAIWSATEQGLAITAGSLATLRPLLRLLGRKLGITTSGRSELRDTDQRTGTGLGKFGPSRATNSGNKQGDLFGLATFARENDLDGHGRDCEAAYAGKDHFGRPSAERTVVSTWNSRRGTGNSSEEELTPGLRPKSSGAVKVTTTFKVEEDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>I1S034</accession>
    <name>I1S034_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG10048.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T07157</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318976.1">
        <property type="nucleotide sequence ID" value="XM_011320674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S034"/>
    <dbReference type="SMR" id="I1S034"/>
    <dbReference type="FunCoup" id="I1S034">
        <property type="interactions" value="295"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1S034"/>
    <dbReference type="EnsemblFungi" id="CEF75383">
        <property type="protein sequence ID" value="CEF75383"/>
        <property type="gene ID" value="FGRRES_10048"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10048"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07157"/>
    <dbReference type="eggNOG" id="KOG3771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025518_0_1_1"/>
    <dbReference type="InParanoid" id="I1S034"/>
    <dbReference type="OrthoDB" id="2159336at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000048">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000189">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="7">
        <location>
            <begin position="17"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="374"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="281"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF75383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="434" mass="49465" checksum="B6A2733A285E607A" modified="2012-06-13" version="1">MSFKGFQKSLTRAPQQFKQKFNIGEHTKDAVYIDAERRFQELETETKKLHDESKKYFESINGMLTHQIEFSQAMTEVYKPISGRMSDPDSIKFEGNPEGIRACEEYEAVVKDLQETLAPELEMIESRIIRPANELLDVIKVIRKSALKREHKRLDYDRHRTTLKKLQDKKERTAKDEKAMWKAEGDVEQATQEFNYFNDLLKDELPKLFQLEREFIQPLFQSFYYMQLNIFYTLHEKMQNCDIGYFDLTLDIEDAFHEKRGDIQEQTEALSICRFKTTGRPRPMRYGAKPALEGPKQPALLTQGGEDSKPSSSAVTSPKIGGWQRPASTANDSAAPPPYTPPTGANAGLAAIAAGKKKPPPPKPKPKPMRLTAPGVETVTALYDYAAQAEGDLSFRTGDVIEIVTRTQNENEWWIGRLQGKEGQFPGNYVQLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1S038</accession>
    <name>I1S038_GIBZE</name>
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        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
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        <name evidence="8" type="primary">FG10052.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T07165</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318980.1">
        <property type="nucleotide sequence ID" value="XM_011320678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S038"/>
    <dbReference type="EnsemblFungi" id="CEF75387">
        <property type="protein sequence ID" value="CEF75387"/>
        <property type="gene ID" value="FGRRES_10052"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10052"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07165"/>
    <dbReference type="eggNOG" id="ENOG502SSGF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079951_2_0_1"/>
    <dbReference type="InParanoid" id="I1S038"/>
    <dbReference type="OrthoDB" id="4074965at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="8"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF75387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="169" mass="19157" checksum="516D4808C5BD0B93" modified="2012-06-13" version="1">MALDRVVSLVLRAAELVFAAIVAGVNGEYLHNARGASSWQLGRFIYTEVVAALGMLFSLLLLIPFSSTFVHWPLDIFMSINWWIVFGLLVDLVGTSCGRVFDWNNVHPVHGDQCGKTKAVIAFSFLSALLWLVSALVGFFWVRKRERTARRAEDAHHNRRRGPWFRSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I1S063</accession>
    <accession>A0A098DAB0</accession>
    <name>I1S063_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
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    <gene>
        <name evidence="4" type="primary">FG10079.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T07231</name>
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    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319011.1">
        <property type="nucleotide sequence ID" value="XM_011320709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S063"/>
    <dbReference type="EnsemblFungi" id="CEF75420">
        <property type="protein sequence ID" value="CEF75420"/>
        <property type="gene ID" value="FGRRES_10079"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10079"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07231"/>
    <dbReference type="HOGENOM" id="CLU_1678050_0_0_1"/>
    <dbReference type="InParanoid" id="I1S063"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF75420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="157" mass="17115" checksum="FCB1EADE89B76156" modified="2012-06-13" version="1">MKVALLLQAELAILQPVTPQLVISQLVILQLVPHPLVVHQLARTQPNVPPVIQLLHENFSSSSCAYAYVHVRAILASHWLLSGARPRISAAKKGNEKRWLARTMYVTTTTMAAPPTFMAMTLAMMTLAMSTFVVLAAPRLGAFARHSGHGCRIPAFG</sequence>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1S141</accession>
    <name>I1S141_GIBZE</name>
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            <fullName evidence="2">Chromosome 1, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319413.1">
        <property type="nucleotide sequence ID" value="XM_011321111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S141"/>
    <dbReference type="EnsemblFungi" id="CEF75855">
        <property type="protein sequence ID" value="CEF75855"/>
        <property type="gene ID" value="FGRRES_10437"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10437"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08103"/>
    <dbReference type="eggNOG" id="ENOG502SQRY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104688_0_0_1"/>
    <dbReference type="InParanoid" id="I1S141"/>
    <dbReference type="OrthoDB" id="4487429at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5010124684" evidence="1">
        <location>
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            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF75855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="231" mass="26226" checksum="EE83EB38C18CB201" modified="2012-06-13" version="1">MPSMFTQRTMVIVLILFLIVFLYDTYGPETDYSDLDIELDQDMLIASRENCICDDEPIDGFGKTYFPRSNFVGSSGGMITGWPARGGYYHLKCSLAELDYLGLDRFNPTNRTGDAKEEEAWCARLRQLGAKWYPNIYYDLAEGGDGIEIPRLYLGWPADGGGVWALQSTKFNANLRGLGRINNAFTMEERWWKIKEYGGTFYADPKDCPYLDLDGSKEPDSKEIDCNPLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1S361</accession>
    <accession>A0A098DZZ1</accession>
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        <submittedName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325106.1">
        <property type="nucleotide sequence ID" value="XM_011326804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S361"/>
    <dbReference type="STRING" id="229533.I1S361"/>
    <dbReference type="EnsemblFungi" id="CEF87410">
        <property type="protein sequence ID" value="CEF87410"/>
        <property type="gene ID" value="FGRRES_11229"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11229"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21541"/>
    <dbReference type="eggNOG" id="ENOG502SIJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044083_1_2_1"/>
    <dbReference type="InParanoid" id="I1S361"/>
    <dbReference type="OrthoDB" id="3915838at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF5">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124751" evidence="1">
        <location>
            <begin position="23"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF87410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="241" mass="25995" checksum="121879C6B454B019" modified="2012-06-13" version="1">MLSTLRRFFAMVVMLMAFSATALPNIRVLPLGDSITKGTGSTGLVGYRLPLRQKILAQGVKVNMVGTLKNGNMVDGHHEGHSGKLLSDINGYWQVPMKARPNVVLIHAGTNNMDRGIDLDIAADIMADIVDGIFKIASDVTILLAPVIWANVPTMQANTDKFNVKVRSLIAARQKSGKKILEVPIDIKKADLGDSKHPNDAGYEKMANAWLKAILEADKKGWLKTPVKMSESDAPGTGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1S3D6</accession>
    <accession>A0A098DYS9</accession>
    <name>I1S3D6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG11314.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T21761</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325930.1">
        <property type="nucleotide sequence ID" value="XM_011327628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S3D6"/>
    <dbReference type="EnsemblFungi" id="CEF87016">
        <property type="protein sequence ID" value="CEF87016"/>
        <property type="gene ID" value="FGRRES_11314"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11314"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21761"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_407700_0_0_1"/>
    <dbReference type="InParanoid" id="I1S3D6"/>
    <dbReference type="OrthoDB" id="3563678at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057230">
        <property type="entry name" value="DUF7908"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25485">
        <property type="entry name" value="DUF7908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124776" evidence="2">
        <location>
            <begin position="19"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7908" evidence="3">
        <location>
            <begin position="146"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF87016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="701" mass="75351" checksum="1CF54FFB3591184A" modified="2012-06-13" version="1">MKWQLILTLGGTFHRVAGLELIGGEEQDDGVICYTYLSTYLAPVDVAITGKELLIAANLPTTRGILPPYFTNRSTSLPLFTFSSNPESSDAIPKPTSIDLFSSSDFVIPSSEPSSLLPPTIATSTEASATTTGAVSGQNVILFIAPPANENRRFVKRAPGRFVGGSDTVEICTNAAVFTLADGQLLDNEDPVYYNGNPYEQFGGQGSPPDGAITREFASVNGVLTFSSRSLPGNSAGFCQDGSGQVYMTFGSSPPRCDPILIRVYAVERCQNGQIIGLDTTTTTEPNQSSTVAEPTNIASSDTETFPFDPSSTVLVVSSASTQMSQSSDLSPETNETTESSESTRISGSPTTDRVTTTTSDSSPSDSPSSSPSTEASLFSTSIETTLPFQSSSSFSFSYTTTAPSESFPSVSTLSTDLSSSFETQSSETPSSTAVSIESSSFFSSAETSTEVSSFSFTETSSEEPTSTTDMLTTTEEPTTTTTASCNSVDPLTTVALANPTPVFDDDIDHGNEFRAITIPWIDDGIAKTGQKKLYISTNGVITVDTGNNNPDNDFLTTDYQANRAFLPYWDELYLDRNKGHTIVYEIFESQFGVELVIEFILGKFDSPGIYHFEANFFQDYNDAVRFQYYTTPEKGSSATIGFQDLLSDHYAQVSYNRANVIADGSSVTISTRYTNNFVILPFDNTECGKDQDRVKAPTDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I1S4J2</accession>
    <accession>A0A098D1G6</accession>
    <name>I1S4J2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T00975</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316030.1">
        <property type="nucleotide sequence ID" value="XM_011317728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S4J2"/>
    <dbReference type="EnsemblFungi" id="CEF72290">
        <property type="protein sequence ID" value="CEF72290"/>
        <property type="gene ID" value="FGRRES_11759"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11759"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00975"/>
    <dbReference type="HOGENOM" id="CLU_2306318_0_0_1"/>
    <dbReference type="InParanoid" id="I1S4J2"/>
    <dbReference type="OrthoDB" id="10304777at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
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    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF72290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="100" mass="10665" checksum="A23F0043E46B8CEE" modified="2012-06-13" version="1">MRQELPSGPPEDNNSVCQTQLMCKGILVDTTAAITVHQTSKGLIQSVCLLQFMSFPLLITVKPSSELANSSAHNSYAMSRAYLGQSTPDRGAVAATELVP</sequence>
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    <accession>I1S4M8</accession>
    <name>I1S4M8_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Nectriaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316342.1">
        <property type="nucleotide sequence ID" value="XM_011318040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S4M8"/>
    <dbReference type="EnsemblFungi" id="CEF72620">
        <property type="protein sequence ID" value="CEF72620"/>
        <property type="gene ID" value="FGRRES_11796"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11796"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01639"/>
    <dbReference type="eggNOG" id="ENOG502SZNV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039072_0_0_1"/>
    <dbReference type="InParanoid" id="I1S4M8"/>
    <dbReference type="OrthoDB" id="4898608at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF72620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="449" mass="49139" checksum="7BD7F8A9B52F5A20" modified="2012-06-13" version="1">MSCALRLPTIRLVAKQANVELSATSSLNIGPLDGARNIENAKDLLSAVKNSHLWISRSGACCIEVSFAIDGCPILERVHLEGLADIISNSEIWDRLGVHLEYNRSLATSLPGLLSFSVQHSDLSSALVAPASAWTASFRSLLLAIDVRRIDERQEPPKKASRTRKRQKRMTSAGEKAELRSESDLLESLGPTDQDAIDAFMSSLNYPSNCGKRKLAKSNSGIESAAYVEVLEGLHSLSLLDILLEQLTLATEKTYKSCRVWGCGPDYCLTKLAPGVFHVPFLKSVSDRAQLLPVIAVSLARMVHAESPAIRQKVVALRPSNGTISSSHNELGDYTSGIEKRAWEVLLAHVQVPSLVKKRRGKRPMLPTAIPCTKSPETLITNEQLDMTPGNDLPQTRASVKQEDQESTVMSVRWDAIAGSQTCLQYGHAEGDPCDFQTLDQWLSCDNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I1S5D7</accession>
    <accession>A0A098D8E1</accession>
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        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
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    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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        <property type="protein sequence ID" value="CEF74226"/>
        <property type="gene ID" value="FGRRES_12055"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04839"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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    </evidence>
    <sequence length="140" mass="14945" checksum="E7ABB59A878BF977" modified="2012-06-13" version="1">MAWGRRPFRLPSKGFSSLGSVFWIRIPVLRSGVAFNLALLHAHPLSSVLCPSAVSGGSKVIAKMVSFWSTSTGLVIVGSKVYGGYTQPTDPLKSKRTGKSASNLKGKKYDSCVFEAIQPKLLSKALERSSLGWEKAGSGS</sequence>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_011321940.1">
        <property type="nucleotide sequence ID" value="XM_011323638.1"/>
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    <dbReference type="AlphaFoldDB" id="I1S6B6"/>
    <dbReference type="EnsemblFungi" id="CEF78613">
        <property type="protein sequence ID" value="CEF78613"/>
        <property type="gene ID" value="FGRRES_12387"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12387"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13621"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF78613"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323924.1">
        <property type="nucleotide sequence ID" value="XM_011325622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S7A5"/>
    <dbReference type="STRING" id="229533.I1S7A5"/>
    <dbReference type="EnsemblFungi" id="CEF88389">
        <property type="protein sequence ID" value="CEF88389"/>
        <property type="gene ID" value="FGRRES_12728"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12728"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17807"/>
    <dbReference type="eggNOG" id="KOG0769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_2_1"/>
    <dbReference type="InParanoid" id="I1S7A5"/>
    <dbReference type="OrthoDB" id="18574at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF2">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="7"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="102"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="199"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF88389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="329" mass="35463" checksum="787CCF614EF2717A" modified="2012-06-13" version="1">MSSQQALSALGHAISGSVGTAISTASLYPLDLVTTRLKAQRKSGGSTEDYDGVISALRGIPANEGGLKALYSGLGTDVAKSVVDSFLFFGFYNYLRPRHRKSTVVEELLVGAVAGGCARALTTPISNVVTRKQMLGSEQSFLEILSEIRKESGLIGLWSGYSATLMLTLNPSITFFVNRRLAARIIPALEEEDVPIAWIAFLIAATSKASATAITYPLQTGKTRLQVGSGSGKSAGAVSGLPKDGSVKPKHVLRRIVDFLNQSIYGVIIRIIKNEGAKALYAGLRGELLKSFFSHGLTMLTKGVIHRFVVRAWFIILLPRLRQRRLQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I1S7E1</accession>
    <accession>A0A098DYQ4</accession>
    <name>I1S7E1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T18289</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324151.1">
        <property type="nucleotide sequence ID" value="XM_011325849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S7E1"/>
    <dbReference type="EnsemblFungi" id="CEF86990">
        <property type="protein sequence ID" value="CEF86990"/>
        <property type="gene ID" value="FGRRES_12764"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12764"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18289"/>
    <dbReference type="HOGENOM" id="CLU_3050478_0_0_1"/>
    <dbReference type="InParanoid" id="I1S7E1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF86990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="54" mass="5858" checksum="BA003DD5613F3704" modified="2012-06-13" version="1">MCNPVRPAMNCKTGSSELVNYANGVCAHNLTHNCFEKAAPNDTLCIMCRNQCPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I1S8X9</accession>
    <accession>A0A098DFA9</accession>
    <name>I1S8X9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T10685</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319999.1">
        <property type="nucleotide sequence ID" value="XM_011321697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S8X9"/>
    <dbReference type="EnsemblFungi" id="CEF77145">
        <property type="protein sequence ID" value="CEF77145"/>
        <property type="gene ID" value="FGRRES_13308"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13308"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10685"/>
    <dbReference type="HOGENOM" id="CLU_1865283_0_0_1"/>
    <dbReference type="InParanoid" id="I1S8X9"/>
    <dbReference type="OrthoDB" id="10273375at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF77145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="137" mass="15485" checksum="5B8240155217A01D" modified="2012-06-13" version="1">MELATADHSVDRGSQHCPISLARVFSTGSASPVRGASEQVSYSCHWAVREEEITPQLLNEQTPRSEVVGPRNLIEFKGERRPRRRLKILLAAQSSRAQIPCIESSIWILAHPSMENTPRTGKEFDLSRYLRSQMNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I1S9K2</accession>
    <accession>A0A098DPS6</accession>
    <name>I1S9K2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T27591</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328534.1">
        <property type="nucleotide sequence ID" value="XM_011330232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S9K2"/>
    <dbReference type="EnsemblFungi" id="CEF83352">
        <property type="protein sequence ID" value="CEF83352"/>
        <property type="gene ID" value="FGRRES_13533"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13533"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27591"/>
    <dbReference type="HOGENOM" id="CLU_2236846_0_0_1"/>
    <dbReference type="InParanoid" id="I1S9K2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF83352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="105" mass="11661" checksum="B354C56EC676CE06" modified="2012-06-13" version="1">MFKEDTLGSPVSRLSKIPATKPMISIRSPTYPPPQSLSLPHNHDKLQISIWIPILDPLASLTSVTVNGCLALPKKNPNDTHHSNQQNASFVDIVNCLLDFQLCRF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q4IPA4</accession>
    <accession>A0A0E0RP28</accession>
    <accession>I1S4U7</accession>
    <accession>V6QVD7</accession>
    <name>YTH1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName>mRNA 3'-end-processing protein YTH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">YTH1</name>
        <name type="ORF">FGRRES_11865</name>
        <name type="ORF">FGSG_11865</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CPSF4/YTH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS231663">
        <property type="protein sequence ID" value="ESU06211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316696.1">
        <property type="nucleotide sequence ID" value="XM_011318394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4IPA4"/>
    <dbReference type="SMR" id="Q4IPA4"/>
    <dbReference type="FunCoup" id="Q4IPA4">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="229533.Q4IPA4"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T02405">
        <property type="protein sequence ID" value="FGRAMPH1_01T02405-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G02405"/>
    </dbReference>
    <dbReference type="GeneID" id="23558684"/>
    <dbReference type="KEGG" id="fgr:FGSG_11865"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02405"/>
    <dbReference type="eggNOG" id="KOG1040">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024513_1_1_1"/>
    <dbReference type="InParanoid" id="Q4IPA4"/>
    <dbReference type="OrthoDB" id="1914176at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000012">
        <property type="entry name" value="cleavage and polyadenylation specificity factor subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000238539" description="mRNA 3'-end-processing protein YTH1">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type 1" evidence="2">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type 2" evidence="2">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type 3" evidence="2">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type 4" evidence="2">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type 5" evidence="2">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="255" mass="29077" checksum="92CF4B4668C0B10A" modified="2012-10-31" version="2">MPSAVESPADAILNHSATSYNFRFSPFLRQTYQVGLSPDRPVCKAFQSGHCPNGTRCPERHVSDSKTSQPTGGLNSLVCKHWLRGLCKKGEHCEFLHEYNLRKMPECNFFMRNGYCSNGDECLYLHIDPQSRLPPCPHYDMGFCPLGPNCSKKHVRRKLCVFYLAGFCPDGPDCKEGAHPKWSKDLEKPTLKSEEKKDEEMRVEFSQDDMDRQRDQQRDRDRDDGGRHRGGHGGHGGHGGRGKWRGRGRYRARGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>V6RDZ4</accession>
    <name>V6RDZ4_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T22521</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326143.1">
        <property type="nucleotide sequence ID" value="XM_011327841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6RDZ4"/>
    <dbReference type="FunCoup" id="V6RDZ4">
        <property type="interactions" value="991"/>
    </dbReference>
    <dbReference type="STRING" id="229533.V6RDZ4"/>
    <dbReference type="KEGG" id="fgr:FGSG_06532"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22521"/>
    <dbReference type="eggNOG" id="KOG3259">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090028_0_0_1"/>
    <dbReference type="InParanoid" id="V6RDZ4"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140463">
        <property type="term" value="F:chromatin-protein adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000066">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000026">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="7">
        <location>
            <begin position="66"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SCB65069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="177" mass="19680" checksum="EA1AAAFD7C860BF9" modified="2014-02-19" version="1">MADTGLPPGWEVRHSNSKNLPYYFNSAEKLSRWEPPSGTDTEKLKHYMATNHSAGSRPGAVPGVPEGKIRAAHLLVKHRDSRRPSSWREAEITRTKEEAFEIIKEHEQKIKSGSVSLGELALTESDCSSARKRGDLGYFGRGDMQKEFEDASFGLSPGQMSEIVETASGLHLIERLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D259</accession>
    <accession>A0A0E0RMS2</accession>
    <name>A0A098D259_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T01493</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D259"/>
    <dbReference type="EnsemblFungi" id="CEF72547">
        <property type="protein sequence ID" value="CEF72547"/>
        <property type="gene ID" value="FGRRES_15074"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01493"/>
    <dbReference type="InParanoid" id="A0A098D259"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF72547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="60" mass="6464" checksum="15C394D4E1C617E1" modified="2015-01-07" version="1">MAELSGVFTKGFKAGGLVSQDLKNFLGSGSGFNVMIEDHAVKDANHLCFSCMVFPESWHA</sequence>
</entry>
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    <accession>A0A098D609</accession>
    <accession>A0A0E0RRL0</accession>
    <name>A0A098D609_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T04155</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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            <taxon>Fusarium</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D609"/>
    <dbReference type="EnsemblFungi" id="CEF73885">
        <property type="protein sequence ID" value="CEF73885"/>
        <property type="gene ID" value="FGRRES_15131"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04155"/>
    <dbReference type="InParanoid" id="A0A098D609"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF73885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="59" mass="6894" checksum="FAD82675EFC65673" modified="2015-01-07" version="1">MTSDASNAEWVRFERDRAREKIMPLKVDMAVVRNALESLDPANRKEPQNDKSHKVKKKK</sequence>
</entry>
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    <accession>A0A098D6S2</accession>
    <accession>A0A0E0RSC7</accession>
    <name>A0A098D6S2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 1, complete genome</fullName>
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    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T04691</name>
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    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ESC family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D6S2"/>
    <dbReference type="STRING" id="229533.A0A098D6S2"/>
    <dbReference type="EnsemblFungi" id="CEF74152">
        <property type="protein sequence ID" value="CEF74152"/>
        <property type="gene ID" value="FGRRES_15909"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04691"/>
    <dbReference type="InParanoid" id="A0A098D6S2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051243">
        <property type="entry name" value="PcG_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10253">
        <property type="entry name" value="POLYCOMB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="128"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="373"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF74152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="517" mass="56774" checksum="AC16483FEBAB46ED" modified="2015-01-07" version="1">MAITDDNAFELPRLRSSFTLENDTEFLENDNCAEFFDVKFCPYQPLDAPPVFAAISKKHVVICTLSQTTDSNPCEVLSVIRDDDDEASACCCTWTKDPETGAPYLCIGGVDAKVKIYDVVNGKLYRCLTGHGGDVNDLATSPANSSIIASASGDTSIRIWSLDPVHANRPCLVILAGEGHSWDLLSAFHDTGRYLLSAAHDQIINLWTLPDLPTEAIQTPARVHYPHFSTSAVHSGIIDCVAFYGDCILSRACHDNVISLWRIEGFSSANPPPAESEAPTAQTTVPTNYEEASRLTRSAFVPTISPQCPSQYTMLLQFYTPNCGPQFFMRFKLHFVPDQHPVLAFCNAAGNVFFWDFERLVAYREFMEALKDPGRDKSKQLPHPSWMRQVKTRSKTDSKGRQGGGDKDVPSTFRADAIRLSEEIGDYNVETLETWASRYSQDDPHEPLKAHKTESSSANFVGRQTAWSPGGEWCVVVGSSNQALILQRWANKGSTSRASASASASVPPSVSAQNGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DB19</accession>
    <accession>A0A0E0RV86</accession>
    <name>A0A098DB19_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG09866.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T06713</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DB19"/>
    <dbReference type="FunCoup" id="A0A098DB19">
        <property type="interactions" value="954"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A098DB19"/>
    <dbReference type="EnsemblFungi" id="CEF75161">
        <property type="protein sequence ID" value="CEF75161"/>
        <property type="gene ID" value="FGRRES_09866"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DB19"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021132">
        <property type="entry name" value="Ribosomal_eL18/eL18-A/B/_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01106">
        <property type="entry name" value="RIBOSOMAL_L18E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="124"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF75161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="157" mass="17553" checksum="1783C442E482392D" modified="2015-01-07" version="1">MVKLYRFLARRTDASFNKVVLRRLFTSKINRPPVSLSRIVANINKEGEKRTVVVVGTITDDNRLLECPKVTVAALRFTATARARILAAGGEAITLDQLALRAPTGSNTLILRGPKNAREAVKHFGFGPHSHKKPHVESKGRKFERARGRRRSRGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DDS2</accession>
    <accession>A0A0E0S0S8</accession>
    <name>A0A098DDS2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG08698.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T10601</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DDS2"/>
    <dbReference type="EnsemblFungi" id="CEF77103">
        <property type="protein sequence ID" value="CEF77103"/>
        <property type="gene ID" value="FGRRES_08698"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10601"/>
    <dbReference type="InParanoid" id="A0A098DDS2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF77103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="246" mass="26495" checksum="0D6B46FEC9CAD288" modified="2015-01-07" version="1">MGPVVGSNTDKVSDKAGGPTYLLCKHNISPNHNHFSRRGCPPLYVLAAGRLDGNTGEETYQHLIWVSSKVILCSAGEKRGNEAAVQKTGRSTCTYCICWGKSYSAAQQQSRYRAPFVAIIGISQPSLPLDLAGCLALLIFVYCALAHGISIPVPTFHYVAWARSGTRGPDCGLAAAFVGFVGCSGEVVFDPSTPAVAVAETDQLDSVSFATPEGVEHNGDGVRKASLMVPRWSADYACHKWWWWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DDV3</accession>
    <accession>A0A0E0S0S9</accession>
    <name>A0A098DDV3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG08699.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T10603</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DDV3"/>
    <dbReference type="EnsemblFungi" id="CEF77104">
        <property type="protein sequence ID" value="CEF77104"/>
        <property type="gene ID" value="FGRRES_08699_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10603"/>
    <dbReference type="InParanoid" id="A0A098DDV3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF77104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="308" mass="34816" checksum="4BB24AC05858228D" modified="2015-01-07" version="1">MDVQLGSSHHTGCLANIWEHRLECSVCPETWHIKTRTPENDHHLRQIISPFLDGDCFKGSDSQKLAGHSRALCEGLLHEQSLLVNDPFFQEQPDTPKIYGSAVPTQFPYDFALHKCECYIVTYQIILIIIRIHSCRAKFACRDGHDQTSCLGTYEGMGSITFRATGMGEEFSLIDQCDWGGMNDEWSRSLVAPPYGTIPVSSVLRLDSLHWRDVYASLIIKLPGTPDKRRKGRAPPAVDAINLWSTELIWHTDGLRLVCQCPWLSRISFSSTWHPVSHRRGILPKQRSLAHSLVLHDSTDSCNGHHVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DHA9</accession>
    <accession>A0A0E0S2X5</accession>
    <name>A0A098DHA9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T12093</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DHA9"/>
    <dbReference type="EnsemblFungi" id="CEF77850">
        <property type="protein sequence ID" value="CEF77850"/>
        <property type="gene ID" value="FGRRES_03113_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12093"/>
    <dbReference type="eggNOG" id="ENOG502T3JI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DHA9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="463" mass="52737" checksum="38155D55D3B5F750" modified="2015-01-07" version="1">MRKDKVKNVPTIEAIRSKLGVGVPGDKESKIFRRVVKEFHQDYKTANGTPGAVFTQWTNPTHQDALRRMAEEFLEVRGWAKRFWPDTAGSGTVKKLKWSENHIQIMRHMRQLFFRHNQQVRKEPGSTPRKRMASRTTPCPSRTISPGSTRTTTTHTGDVTMNDMMGPRHQDDQYDDIFRPSNPYRVPSSPISTTSDRSCTIFDIPQDSNPLLGLPNESSGPTSRPLAPVAPMSERAVHHSSPFGTSDSEAGINSPRWGSPVLSKRKKSEWRCSPDLGTPRPRKAISSGNTGSVRHNSRPSSISEDVARLSTEDRILSGEADEPIMVMPPPPRPRPVLQTNNAQRRVNIKYEVEISPGTFRRWDHRGAFNHMSIEEFQDIHDFHDIDSVQFILKRRGMSWDDVVSRDNEDGFKDMRTRLKDRIQEDLAEIGFSQDVVLYSIVIVPIRRTSETNEDFIRSQTIFL</sequence>
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<entry dataset="TrEMBL" created="2015-01-07" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DHR9</accession>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DHR9"/>
    <dbReference type="EnsemblFungi" id="CEF78509">
        <property type="protein sequence ID" value="CEF78509"/>
        <property type="gene ID" value="FGRRES_16226"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13411"/>
    <dbReference type="eggNOG" id="ENOG502SNUJ">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GO" id="GO:0005634">
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    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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            <begin position="16"/>
            <end position="45"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="639" mass="71240" checksum="1BE9E1D6EC79C424" modified="2015-01-07" version="1">MPTDSSSKVVGVRRRACVNCTSVKSKCLPLSADECQRCNRLGKRCTYLNVVEKRKSPSSASRTRLLEQRLNRVLTMLSERAKGTPLSGFFTQLSTADLDLEIDMLGVDRIPGSSLPRSFAPQQRLDVIDHGFITLGEAQILLDNYRTRAVPHFPFVPISPDTTVASLKSAKPFLFMCIVATMKVDNCTIQRQIGEEVRMQAHQRVLMQSESSLELLQGLLIYIAWYQYFFSYEKQQIVQLAQLCVSLIQNLGLDQNPDNKRRTVDLGPDETAAGRKAARSTDQLRALLGTYCTASWVSTKFRTRCAIPYTGYIKQSWEILSARNEYASDDLIAHLVRINEMSRRICDTFGYDDLENTGVKGEFISAMALQTLSNESTLLKASIPPEFQENFSIKIELHLLDTLIGEVSLHDDFWDHSSIASSFTTSDPSLSVSTRMSIMFNLLRSCKSLNDTVMDYPDEELWYITFYTTAKICRTLSCLSNASKIWPEIFRDIGIALSNASFSYPGTSLYDATTIERAADLEGEARRLQTKFKNLSPLVQNTSDEADIMLGFSDMIWAVFATYDEVRGKNHGPLDFSIGCDVPCSSSEMGSSGGYLSSTGSGNTLTDAVLELEGIDDSTWEELLAGITATTEREAALQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DIZ5</accession>
    <accession>A0A0E0S5X9</accession>
    <name>A0A098DIZ5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG03991.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T14203</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DIZ5"/>
    <dbReference type="EnsemblFungi" id="CEF78904">
        <property type="protein sequence ID" value="CEF78904"/>
        <property type="gene ID" value="FGRRES_20188"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14203"/>
    <dbReference type="InParanoid" id="A0A098DIZ5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF78904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="222" mass="25210" checksum="392F5008E9CBF717" modified="2015-01-07" version="1">MSLRRLREITRLLQSATTALGETADELQTRVMALEEAAHELQTRIRALSLERLPDTGYAIDGRGPDINWAERQGEHLADTTEDRSTLNVSDATDPVTSSPWLHYMRPRRPMALAPLPFPLSPNYPDYTPSFPRPIDEHFRSLTIRTPSSDSDDTGDRTVSEDWVAERAELEQAERERFQMAYDNEVLESNDKDASTREESDSDVAMEEANDLDGNKEENDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DLU6</accession>
    <accession>A0A0E0S7I0</accession>
    <name>A0A098DLU6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG04445.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T15307</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DLU6"/>
    <dbReference type="STRING" id="229533.A0A098DLU6"/>
    <dbReference type="EnsemblFungi" id="CEF79455">
        <property type="protein sequence ID" value="CEF79455"/>
        <property type="gene ID" value="FGRRES_04445_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15307"/>
    <dbReference type="eggNOG" id="ENOG502S0RY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DLU6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd07253">
        <property type="entry name" value="GLOD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050383">
        <property type="entry name" value="GlyoxalaseI/FosfomycinResist"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21366:SF14">
        <property type="entry name" value="GLYOXALASE DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21366">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="9"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF79455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="138" mass="15224" checksum="ED4E41E7B5C8E841" modified="2015-01-07" version="1">MSSFAVVKDIDHLVLTCHDVQATIAWYTKYLGMKHEPFGPESSPRHALKFGTHKINLHQRGNEFEPKAQTALPGTADLCFILEEGTDLQGLITEFEKEDIKVLEGGGVVARTGAMGGIKSIYVRDPDGNLIELSYYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DQK6</accession>
    <accession>A0A0E0SCH2</accession>
    <name>A0A098DQK6_GIBZE</name>
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        <submittedName>
            <fullName evidence="9">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FGRAMPH1_01T25175</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DQK6"/>
    <dbReference type="EnsemblFungi" id="CEF84135">
        <property type="protein sequence ID" value="CEF84135"/>
        <property type="gene ID" value="FGRRES_16852_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25175"/>
    <dbReference type="eggNOG" id="ENOG502T5B7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DQK6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF92">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="25"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF84135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="337" mass="38422" checksum="D8FA5E33BF2C4394" modified="2015-01-07" version="1">MAPGASALLIMEWTLISLSTLVIAARIWLRLGLQKQRLLGSDVWMTCAWAMGIITASFCITYVHMGVMEDGIDPSLTNFDASDERKQLILKLLWISVLPFVTSFYLCKAALLGVYHQVIPRFMTKRRAFLWATVCYVVASFVVTVVLLFTICTPVDRWWTFDTERQCNRDPLMSFFRAIWALNFSCDIFIFVLPWLIVPDLMIKGWLRIGVYFTFLLGLINMSLSIVRYTKVYTGVEASLVTIHFWNSLDLYIGLVIACLPALRPYFKYATESRAFNYMRSKTGTRGSSQYTTNATTASSHAVKLSQVPPKGSFDGSEDRLSQLSLVHVRPEDEERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DS77</accession>
    <accession>A0A0E0SE62</accession>
    <name>A0A098DS77_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG09085.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T27963</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DS77"/>
    <dbReference type="STRING" id="229533.A0A098DS77"/>
    <dbReference type="EnsemblFungi" id="CEF84725">
        <property type="protein sequence ID" value="CEF84725"/>
        <property type="gene ID" value="FGRRES_09085_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27963"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DS77"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.10">
        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF2">
        <property type="entry name" value="CELLOBIOSE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G17620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010018722" evidence="5">
        <location>
            <begin position="22"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="6">
        <location>
            <begin position="795"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF84725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="838" mass="90370" checksum="CBDFD6B23B95C3F6" modified="2015-01-07" version="1">MVSFRSSWLLAIASLTQYVAGQQSAPTSLTDANTGIIFDTWKAPSMTFGFTFPADGQTTNADEFIGYLNCATPKGKSTGWCGLSYGGSMTNSLLLFAYPHDGEILTTFHWASAQVEPVQYKGKATLTQISSKITDDGFTLIYRCQGCTSWSQDGSSGRLATTSTVAVLGWAHSLTNAINPECPAEARMLQHETQSIFGGQLTSNAFNSKYADWAKLATKVVKGDCDGSEPTATATGEPTPTAEPTGNPVPNETYDYVVVGGGAGGLPIADRLSEAGKKVLLIEKGPPSTGRWGGTRKPDWLKGTDLTRFDVPGLCNQLWVDSAGIACPDTDQMAGCVLGGGTAVNAGLWWRPTPEDWDYNFPDGWKAKDMAKYEQRVFSRIPGTMVPSMDGKLYLDQGFKVVAGALNKAGWGEVNALKEPTAKNHTYTHPPFMFSGGERGGPLATYLVSASKRNNFKLWTNTQVRRLVRSGGHVTGLEVEPFAGSGYAGTVKLTPETGRVILAAGTFGSAKILLRSGIGPEDQLDIVSKSSRDGSSMIKKDQWINLPVGYNLEDHTNTDAVIKHPDVVFYDFYEAWDTPNAGDKSKYLDARSGILAQAAPNIGPIIFDEIRGADNRVRSMQWTARVEASLGENDTKAMTLSQYLGRGAKSRGRMTITSALNTVVSGNPFLNDPEDKKAVVKALDNLRKALSGVKDLVWLQPAPSVSSQQYVDDMVVSWSNRRANHWIGTNKMGKDDGRQGGTAVVDLNTKVYGTDNLFITDASIFPGMVTTNPSAYFVTASEKASDAILALPVSKAQEPYKQCGGTEWNGSMQCGKGYYCKALNPFYGQCYPEVSYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DT67</accession>
    <accession>A0A0E0SF48</accession>
    <name>A0A098DT67_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T27807</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DT67"/>
    <dbReference type="EnsemblFungi" id="CEF85061">
        <property type="protein sequence ID" value="CEF85061"/>
        <property type="gene ID" value="FGRRES_20403"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27807"/>
    <dbReference type="InParanoid" id="A0A098DT67"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF85061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="66" mass="7779" checksum="5E157BEE7200C471" modified="2015-01-07" version="1">MTKEKQVLVGRYYDKVKLQRALERLFPEENGAFELRMTNDNWVFYATREVTKDELVSARLPSTAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DTZ1</accession>
    <accession>A0A0E0SCY0</accession>
    <name>A0A098DTZ1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T24987</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DTZ1"/>
    <dbReference type="EnsemblFungi" id="CEF84293">
        <property type="protein sequence ID" value="CEF84293"/>
        <property type="gene ID" value="FGRRES_15432_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24987"/>
    <dbReference type="InParanoid" id="A0A098DTZ1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF84293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="49" mass="5757" checksum="2174663E81C81D5B" modified="2015-01-07" version="1">MSEDVYFITNWSTSMKVKYKTVHGDVVYQSHLPQHSPHMYVAHKLALNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DUU8</accession>
    <accession>A0A0E0SFB1</accession>
    <name>A0A098DUU8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T23563</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DUU8"/>
    <dbReference type="EnsemblFungi" id="CEF85124">
        <property type="protein sequence ID" value="CEF85124"/>
        <property type="gene ID" value="FGRRES_20350"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23563"/>
    <dbReference type="InParanoid" id="A0A098DUU8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF85124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="95" mass="11046" checksum="4F721CA42B07EBBD" modified="2015-01-07" version="1">MSGPSRVSVRTDFRIQGVIGTKAQSQCLIREHEQKYEQEQEHQHKHSIFASHRFFDLALSRIASLWKYHFFQKMTLLRGYNGQVATIRSKGGPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DWQ5</accession>
    <accession>A0A0E0SH69</accession>
    <name>A0A098DWQ5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG07430.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T24805</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
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                <person name="Miranda-Saavedra D."/>
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        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
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            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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            <authorList>
                <consortium name="EnsemblFungi"/>
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            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
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                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
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                <person name="Mitterbauer R."/>
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                <person name="O'Donnell K."/>
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                <person name="Qi W."/>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
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                <person name="Dufresne M."/>
                <person name="Freitag M."/>
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                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
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                <person name="Park J."/>
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                <person name="Wapinski I."/>
                <person name="Yoder O."/>
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                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Magnuson J.K."/>
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        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Shim W.B."/>
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                <person name="Xie X."/>
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                <person name="Kazan K."/>
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                <person name="Miranda-Saavedra D."/>
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                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
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                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
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        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
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                <person name="Seong K.-Y."/>
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                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
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        <property type="gene ID" value="FGRRES_20252"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
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                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
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                <person name="Mitterbauer R."/>
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                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
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                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098E285"/>
    <dbReference type="EnsemblFungi" id="CEF88210">
        <property type="protein sequence ID" value="CEF88210"/>
        <property type="gene ID" value="FGRRES_12743"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098E285"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF88210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="139" mass="15290" checksum="599FE34F8E143815" modified="2015-01-07" version="1">MESNTVVSVFLYTCINIQSQEIMPAGELSSSPVNLEMFHSLRASLILGSVHAHTMRRSSDGVYSLATRYGNSFFGNANTSRKCLTCSGRGANISTYLYLQPVHSCSKDLFLPALRGHGYCVFMQMSNLSENPCSHDDIP</sequence>
</entry>
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    <accession>A0A0E0RTX5</accession>
    <name>A0A0E0RTX5_GIBZE</name>
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        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
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        <name evidence="2" type="primary">FG02412.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T05791</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RTX5"/>
    <dbReference type="EnsemblFungi" id="CEF74700">
        <property type="protein sequence ID" value="CEF74700"/>
        <property type="gene ID" value="FGRRES_15989"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05791"/>
    <dbReference type="eggNOG" id="ENOG502SSJC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0RTX5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF74700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="199" mass="21588" checksum="EDA85128C240F178" modified="2016-04-13" version="1">MRELLNKVLYGSSSPQGVSSNDGSQSLIIRPHPNDDNLLFITPSGSPKDAPPLYTISKRLSNPNFILHRGFPAPENAVAVASMHISTSTVDLSVYNQPMVIKNSSMTGSWSFDTHMGKFKWKVNQYTGTGFELYDRQGNKIAKYGNAGLMNFGEKQLSIYVPGDEFFIAMVLLSAVASKELAKIIEEVVGEVAGAVVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RU90</accession>
    <name>A0A0E0RU90_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI ethanolamine phosphate transferase 2</fullName>
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    <gene>
        <name evidence="16" type="primary">FG02509.1</name>
        <name evidence="15" type="ORF">FGRAMPH1_01T06021</name>
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    <organism evidence="16">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CEF74815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="interactions" value="489"/>
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    <dbReference type="STRING" id="229533.A0A0E0RU90"/>
    <dbReference type="EnsemblFungi" id="CEF74815">
        <property type="protein sequence ID" value="CEF74815"/>
        <property type="gene ID" value="FGRRES_16009"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06021"/>
    <dbReference type="InParanoid" id="A0A0E0RU90"/>
    <dbReference type="UniPathway" id="UPA00196"/>
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        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051267">
        <property type="term" value="F:CP2 mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16024">
        <property type="entry name" value="GPI_EPT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPI ethanolamine phosphate transferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037674">
        <property type="entry name" value="PIG-G_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039527">
        <property type="entry name" value="PIGG/GPI7"/>
    </dbReference>
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        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
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        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2"/>
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        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
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            <begin position="12"/>
            <end position="34"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="448"/>
            <end position="470"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
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    <feature type="transmembrane region" description="Helical" evidence="13">
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            <begin position="569"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
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            <end position="611"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
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            <begin position="640"/>
            <end position="660"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="712"/>
            <end position="733"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="753"/>
            <end position="781"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="793"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="831"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="14">
        <location>
            <begin position="440"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022824"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF19316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CEF74815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="861" mass="95472" checksum="7C7A90161E147409" modified="2016-04-13" version="1">MVPSHNGSLLRTLLLIAANLLIPASIVVFALGFFPYKPFLPGLAEFESLDFGSPPNAPFDRLIFMVVDALRSDFVYSDTSGFSYVQSLIRDGSAMPFTANARSPTVTMPRIKSMTTGSIPSFVDLILNFDEGDTSSTLASQDTWLAQIKAHGMGKLLMYGDDTWLKLFPNTFDREDGTTSFFVADFTEVDHNVTRNIAPELENNDWGLMVLHYLGLDHIGHKAGPKSPNMIPKQEEMDSIVETLFEAMKTKPHLDSTLLVLCGDHGMNDAGNHGASSPGETSPALVFMSPKLKSISSKLPAPAQPKDEFDFYSMVEQSDLAPTIAALLGFPVSKNNLGAFIPDFLPFWDKTSDQIQILVRNARQILNIVTAAFGSELFDSKSSVDPCALEQTEINELACQWRKINKEAHVLAAGDNLDQKWLDEMSQWLRRAQDLMSSMASNYDMPKLYIGQAIAAIAAVASAMVVVSLGAHRDRQILPFALLTLAYGAMMYASSYVEEEQHFWYWASSIWLVIQGVLHVRRKNSTEEAAWVFVALAALRITRGWNQTGQKFAGDPDIVKSFVVTHPQLLWGIITLGYMMLSFRLLARLKSLPSLASTSITSVLLMSAYSFKLDFTSEDAPELVVGFAKSLNDLLVGQSLLWRARTAFILLSLLFGYGIYRSFTGGRNWQMQSAYLFHHLYTIFGMTQSRATNIPLFHLSDILFHALQATDLSVTGITITAILLQYTTFFAFGGSNAISSVDLSSAYNGISGFNFFAVGFLTLVSNWAGPIFWTSAANLLLLRKYHEGQRNAFWQYIALQTLFVSATVALVMAACTSLRTHLFIWTVFSPKYLYCMAWSLGQHLLINVGFGGLLFWLGSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0S0E1</accession>
    <name>A0A0E0S0E1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG08589.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T10325</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0S0E1"/>
    <dbReference type="STRING" id="229533.A0A0E0S0E1"/>
    <dbReference type="EnsemblFungi" id="CEF76966">
        <property type="protein sequence ID" value="CEF76966"/>
        <property type="gene ID" value="FGRRES_17008"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10325"/>
    <dbReference type="eggNOG" id="ENOG502SKGN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0S0E1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="459"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="654"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="730"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="767"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF76966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="878" mass="98268" checksum="A4E3B20C447B8AF1" modified="2016-04-13" version="1">MNFQNLNFDFVEGSRQGPPKRQTPGQQSIDDDDQSQPILHPYYDLRQRVGRNSTNPSASPPGALFFAPSPPSLPPSKVTASSAEIYGPERLFGSELPGGFAAPTPPTQTHYTAPPRPRSARSARAAPPTSVALASPPAAVRPTSVRFDEAQLAMFAAENSARMASIKDELTIAAGKVTPGVDDTPYIQYAIEALTRNHGGPSTARFPSGSSNDYEDDYAQPRRYANDEMGHHQLRRPEPAYVEDRLPEPIETRAPQEEIPTEMFHAAPAARHEVRNPPKQPTPSSQSEQDQFAQREKARPRSIPVDRAHPPLTFKPAIIRPISLSIFVVLCLLMIAALIFCAVYSQKEFGFTPYPGSIYSGQYFLFRIMPQIFAAIVLLYAQSVVAASMRTLPFAAMADAEPRARYLALFRRLYPLTFLLPSLTGPWQFQFFSVCTWLANFTIPLMSTAFSCIYQDGDWVWAAVQGIAWTLVAIYILLLIATILLMLYWSKRWTGLMWDIRSLGHLLPLLSQSNTTKSYEGVDVVQRSSLFQAQLRDRHLDRLGYWQMDGPQGGMWYGIGSVGEDFQGDRSTYKIIPKKASYNISPASSRDDLEAEVRYAHYRYLHIALRTPVILGSVVFMTLFILAILVVSFLPQTRLDQGYFPQVPARPNGGSFSAANFLYAFVPSVLGMIMFLLFQSVDHTLRVHQPWADLSRSSGSIASKSILVDYAACLPFQCTWNALRNGHWRVAVMSFMATVFIFIPILAGGLFMALTNFRGQVKMFPNMPVFGVLLAFLFLYLGCLTLMLPRRQALRIPHPVNCLAELIALCTAEDTVHDEAFLAVRDTADLKSRLGLDRPNSREQSRWYFGVAAGRDERRLSVRPMQKFTEKMRSTRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SGT0</accession>
    <name>A0A0E0SGT0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG07295.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T24451</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SGT0"/>
    <dbReference type="SMR" id="A0A0E0SGT0"/>
    <dbReference type="FunCoup" id="A0A0E0SGT0">
        <property type="interactions" value="574"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A0E0SGT0"/>
    <dbReference type="EnsemblFungi" id="CEF85643">
        <property type="protein sequence ID" value="CEF85643"/>
        <property type="gene ID" value="FGRRES_16809"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24451"/>
    <dbReference type="eggNOG" id="KOG0581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0SGT0"/>
    <dbReference type="PHI-base" id="PHI:1194"/>
    <dbReference type="PHI-base" id="PHI:3917"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050850">
        <property type="term" value="P:positive regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000294">
        <property type="entry name" value="Map kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000263">
        <property type="entry name" value="MAP kinase skh1/pek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF5">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINAE MKK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="227"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="158"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF85643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="524" mass="56653" checksum="BD84C80172F7F1BC" modified="2016-04-13" version="1">MADQQPQGNDPTPQPQQSAAPTPISLPTHNSGPSPVPLLRPAIPGARNGGARTPRLGLAIPPSPNAKPVGNQPIAAPSRPPLPTLHLATPMGSQVAPQEQLPRSQCVTQASAGGGSESSAAHSRSGSFGPLDGRASNPTSAGSQYSALSFASQYGIGVSRPQGTPDPVSAVGSMYSERSEGGVSMERDGSLQGLEAFDKLTIEKARTLDVDDLDEEGWRIASLEKRIVEIGNLGEGAGGAVTRCKLKGGNTVFALKVITTNPDPDVKKQILRELGFNKECASDHICKYYGAFVDPSTATISIAMEFCEGGSLDSIYKEVKRLGGRTGEKVLGKIAEGVLGGLTYLHTRRIIHRDIKPSNILLCRDGAVKLCDFGVSGDFGTKGEANTFIGTSYYMAPERITGQSYTITSDVWSTGVTLLEVAQHRFPFPADGTEMQPRANLIDLLTYIVRQDVPKLKDEPDMDVYWSNNFKYFIECCLEKQPNRRASPWKMMEHPWMVEMRSKRVNMVKYLSYVWGWGDQPKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SM68</accession>
    <name>A0A0E0SM68_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T16111</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SM68"/>
    <dbReference type="EnsemblFungi" id="CEF87531">
        <property type="protein sequence ID" value="CEF87531"/>
        <property type="gene ID" value="FGRRES_20225"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16111"/>
    <dbReference type="InParanoid" id="A0A0E0SM68"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF87531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="49" mass="5797" checksum="27051530C8E8F391" modified="2016-04-13" version="1">MGISETFRYPMSMKLVLMVLHKATIDKSRDSYIDFKVVSVIWEFSFEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SQF9</accession>
    <name>A0A0E0SQF9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG04822.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T16395</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SQF9"/>
    <dbReference type="EnsemblFungi" id="CEF88672">
        <property type="protein sequence ID" value="CEF88672"/>
        <property type="gene ID" value="FGRRES_16422"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16395"/>
    <dbReference type="eggNOG" id="KOG4266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0SQF9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7580" evidence="2">
        <location>
            <begin position="175"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF88672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="980" mass="110006" checksum="898B98949832D65B" modified="2016-04-13" version="1">MNWGIATSTGCNKISLMQLTYKAIQQITTTLRLDEQDEDLKAFYSKLIVYCTIIESRLISFRETDFSPSSLVNLLSTPLERIFTDTFRRLLVSSWPLELAKLHGRIRSIKNNAAKIEILGIYLEIGSTSDVHDEIAKSLDFCENELRVRYPEDLSHWAFEDLAPQLSISEPTYAVWNAAQSIFKAMVSCMDCPCTPAHDLSARLFMGTYRKPEIQSNDKIDQVDFNMFLSSQQNWQEAIVHTTKEKKVQIVIDEPHGQRPKKECIRTMKVKSLCEPIAKINSKASYRLVFKVTQNQLFKLQSERSGKPIDNSQSAVSLDEFLRNRSGSLTEKTKRILAVILASAVFHLHNTPWLQSTWSSSDILFFRTPSSAIPLRPFIHRPLSSLHQTEEPISNDGTALDSDDIDPDDIDPDDILSHDCPTLVILAIMLLELYFVAPFDILAQRFNINLEPDSQTTAFTRYMDVNYVFKACQKEIPNNSQFYLAVENCLDPKVWQDEEGRKLDEPTLRAKIYKSVVLPLETELSQAYGDVRIEDLDRIAQDIDFGCWGQPLKTRDQQSSTSNANGRVSVSADCPRQCSDVLPLRHQHTDENSRDSRALMDPPSNKRRCSRSPSGVESNGVLSELSSLPDVPSYSRSSYTVGILCALPLELLAVRALFDAKHDSPRYIRGDSNTYALGTLSNHMVVAACLPAGEYGTNAAADSASNMKRTYPNIEFCLLVGIGGGAPTQDNDIRLGDVVVSLPTTKYPGVIQYDLGKEIEGSTFELTGSLHRPPRCLMTAVSSLRSNPDLPSNALQSSLEEVTRRVPESWKARYTHPGQDRDCLLKTTCTSCQTQGACSNREAHVHKRTPRPTNHPEIHYGLIASGNRVLKDACVRDRWARDYGILCFEMEAAGVMNTFPCLVIRGICDYADSHKNKRWQHYAAATAAAYAKLLLGHTAANITDCVRLSMEGEQEGFLVNELEERSFKRQRVSNVMVDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YI67</accession>
    <name>A0A1C3YI67_GIBZE</name>
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        <submittedName>
            <fullName evidence="5">Chromosome 1, complete genome</fullName>
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    <gene>
        <name evidence="5" type="ORF">FGRAMPH1_01T03961</name>
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    <organism evidence="5 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YI67"/>
    <dbReference type="FunCoup" id="A0A1C3YI67">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YI67"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03961"/>
    <dbReference type="InParanoid" id="A0A1C3YI67"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SCB64284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="100" mass="11333" checksum="CBAFBDF0A6816CC0" modified="2016-11-02" version="1">MVKLGDADLKFRERHVPAIMHATRFLLKRSVWKGPHLVPLPIVWPKSTSDKVPPVRTQARSATILPNFVGLKFEVHNGKDYHEVTITEDMVGHKLGEFAP</sequence>
</entry>
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    <organism evidence="6 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
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    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YI68"/>
    <dbReference type="STRING" id="229533.A0A1C3YI68"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03581"/>
    <dbReference type="eggNOG" id="ENOG502QRT9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YI68"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MYB DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
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        <property type="entry name" value="Homeodomain-like_sf"/>
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        <property type="entry name" value="Myb_dom"/>
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        <property type="entry name" value="SANT/Myb"/>
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        <property type="entry name" value="Telomere_rpt-bd_fac_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052833">
        <property type="entry name" value="Telomeric_DNA-bd_trans-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807:SF1">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08558">
        <property type="entry name" value="TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="589"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="420"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="535"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="571"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="702"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="580"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="675"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="705"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="730"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="751"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="785"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="840"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="866"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SCB64247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="920" mass="100219" checksum="38510FB556B80B52" modified="2016-11-02" version="1">MMAEPAQPELSAAMSPTGIKQEPSHEADILEGLDLDLESIMQAATKRPFEDHSNDDDPNKRVKSETEPVQQNTLELDQGAEESLEDGLALLVHNALNNANDFMFDTTTDQMDIDGIPDHHLPPPPPPSSPSVTFFSDPQKYLRKASRHALGNMALSVLLLFSQSFDDSIKPIQDADSQHAKSFHDLQTSFAQIKQIYSSGPILSADEPDLQDHESRTILDLANLAQFCIWLLQTTPSYSEAHQHFHAIFRGQVSDLGSDALDLYLSLKTQVAIDALVSKTTEQSSEQVLEEALINGMEDKLRGLHNGFDLTPADSEFITSVRSRKTSLEGETSTESAVLREKYKVDDLLRQVSTCVKTRLALMSDLGSRLGHPMRSSEETAVDLLGDTSCDPTLDMEDLSSFFEKTTSGLVQDALAGLTEDTTTTNPNPEPNPDPIPEPAPAVAETIEPAPTAEPTKTPEKEPSSTPQTNGKPDLITDYKELEALVAESTSNYVKTTLHGLSPAPYQPTVPQSTTQTYLNQLQQQQAHNTYYSSYTQSIPEPQPPPPEPGHNLPPNQTFPSAILYDKARQAALSKNSSHTRREGLHSTRRPWTQEEEKALMAGLDMVKGPHWSQILTLFGQSGTISDILKDRTQVQLKDKARNLKLFFLKTNSEMPYYLQAVTGELKTRAPTQAARKEAEERARLSSEEQRATLNGIMTLAGGLQNPQQGQGRAAGTPTSAVGSGVMTPAQAASAAQAASSQQGQAHNQATTHSYNPATSSGYPPSTLPQSRPSIMSPPQQSPHQAARPQSSQMSMSPQTPRSQVPQQNHNAMHSPVHAQAAAQMRSHTSTPVGQLHHSPPTQHTPTTQPAAQHHAQTHYAPVPHTQLSYPSPTSTNATPDMHSHNHVPAPETQMDQHMHDNAAEAALLQGLQAAVAESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YIN6</accession>
    <name>A0A1C3YIN6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T06197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YIN6"/>
    <dbReference type="STRING" id="229533.A0A1C3YIN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06197"/>
    <dbReference type="eggNOG" id="ENOG502RWEH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YIN6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="698"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB64454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="894" mass="101725" checksum="3FD2691FB7787E6E" modified="2016-11-02" version="1">MAHAHGGHWDPNSIGNYNQTSPPVHHQPHGGAYTPGSSVVSYQNQPYTHPYQQAVSPPTSPLSAQSTGYVTSPLSHHPSQQNTMQQYQQPIAYNGQQSVVYQQQGSGSGQQESPMQNKSATAPVTTTALNTTSSNQIEKERAEKEFPVKLKGSKHFFEPRSIYRWRNPVLYQKPGYNYTNNEVKIRHRDYAGRVEYKTRSDRYLHPNDGHLRNMYVACVDDIFEGPGTSTWKRTYVRKVAPLKVRIATWIIDFSYDPQSWEDWGIMVLRTFPAAIAMMLVFWEGKPNVIRRKLYYAPVLYKYHGDAKVWSNLYENRKGLSLMARNNTIYRMLRPRYLCFLREAFNDEIRGVDVRSVEEWENSDGQDVNLSYLFVAYSTEHFSHNSQEDMTALHHIAETACRAAKLPAYWIACSCMRDENELESDVYRISDVLRGSDRMVIAVGRGKGSRAGSSGKANTETLLREWGSRMWTFPEVLLSPGRTISIYTRDGNLQSPMVVAKNQFAAQVWTYMDSDVARHLIDHYLGSISLSRLEQAVLALKCLYSRHTTEYLAGDQAYALMGLLRLRPQVDRTDTAFQAFSRLSLANDSDQLLERYICTLPLSLEQPWYDMQDAYESSLWDITPYCQVAGISDNDTIIIDGAWGISIRWKAFYPVYWSTGPSWKRWFSELAVEWNGGFFIAAVSLLAAGAPLGSYGASYIIPGVLFLLLFLYIWMITPNLVRVIYSGKFAATQAEMFGFEGHLNAPTIERSIFGGAFGRLAWSTSGSLLSRSVINEFGERVGIDPCRDPEVRMKVERAKQARPGEMRIFTLVDTYNMEMTLFEAVRPPVTLMFCASEGGMQRAIGCSYEWETQTMYRETVLRMPTTALNRMDRVPRFRMGIQRPQHPSAPYTGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YIQ2</accession>
    <name>A0A1C3YIQ2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FGRAMPH1_01T05647</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YIQ2"/>
    <dbReference type="STRING" id="229533.A0A1C3YIQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05647"/>
    <dbReference type="eggNOG" id="ENOG502S50Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YIQ2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF4">
        <property type="entry name" value="DOMON DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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            <begin position="24"/>
            <end position="390"/>
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            <begin position="218"/>
            <end position="238"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="4">
        <location>
            <begin position="66"/>
            <end position="150"/>
        </location>
    </feature>
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        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SCB64408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="390" mass="41714" checksum="BA26773B164F0D62" modified="2016-11-02" version="1">MKTMIEKTLALVLLLLFTSTAYSSPASYCDASSKKICYSWAVPSSTSSSTSNDLYLRLEAPTDYQWIALGTGSRMSGSTMFVIYQDGSGNVTLSTRKGEGHVMPNYNRMSNVKLLSGSGTSNKTMVANIHWSDATGIDLAGSNHWISAWKKGSSLDTSDTSADINEHDGTDDFSVDLSKASVNGNGNPFTNSTSTQKSDNAVSGGGGGEDNTGSIHGAIMAVVFLLGFPIGSVLMPFIGKWKIHASWQMIAFIGMWVGVGVGKAAADHGGDSFSDPHIVLGGIVCVLMIVQPVLGWMHHRNYVKFQRRTTISHAHIWYGRGIMIFGIINGGLGLNLSGASTTLIIAYSVVGVVVSMIYTGGAIHKMVQQRRKEHQPMSDTSNSALELMHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJ69</accession>
    <name>A0A1C3YJ69_GIBZE</name>
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        <recommendedName>
            <fullName evidence="3">linoleate 8R-lipoxygenase</fullName>
            <ecNumber evidence="3">1.13.11.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FGRAMPH1_01T06395</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(9Z,12Z)-octadecadienoate + O2 = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate</text>
            <dbReference type="Rhea" id="RHEA:25395"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:58659"/>
            <dbReference type="EC" id="1.13.11.60"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.60" evidence="3"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJ69"/>
    <dbReference type="STRING" id="229533.A0A1C3YJ69"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06395"/>
    <dbReference type="eggNOG" id="KOG2408">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJ69"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052878">
        <property type="term" value="F:linoleate 8R-lipoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CYP_LDS-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF13">
        <property type="entry name" value="LINOLEATE 10R-LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0349">Heme</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SCB64471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1151" mass="128879" checksum="D27FCBDBF173FDCC" modified="2016-11-02" version="1">MSFNEKYQAGESYKDTSKEDPSSLLDNPEKLVADLMKDFAGVRSQASPADLLALVKQLLSKGQPLDDKKGTTELLIGILTALPRSSKARTALTNKLIDTLWGNLQHPPLSYVGGDVKYEVAGAEPDHKSHCAQYDTIEFQVPGTNVTLKEQVPQAPDGLHQYRMPDGSFNNILEPNLGKAGTPYAKSVRTEKRLHGVKPDPGLLFDLLMARDEGSFKENPAGISSMLFYHAAIIIHDIFRTNRTDMNKSDTSSYLDLAPLYGSSLKDQLEIRTMKEGKLKPDTFHEKRLLGQPAGVNVMLVLYSRFHNYVADILLKINENGRFSMSTPPNATEEEKAKAIAKQDHDLFNVARLITGGLYINICLHDYLRAITNTHHSASDWTLDPRVAIDKQFDGEGVPRGVGNQVSVEFNLLYRFHSCISKRDERWINGFFLKLFPGRKAEDLQDVSWTELGQALMTFEANTPKDPSVRTFDGLERQADGTFKDEDLVNILKTAMEDPAGCFGARMVPKALKVVEVLGIIQGRKWQCASLNEFREFFGLKRYNQFSDINSDPEIANILEKLYTDPDMVELYPGLMVEDIKPQRNPGSGIMPTYSVGRAVLSDAITLVRSDRFNTIDYTVSNLTSWGYNEVQQDYKTLGGSMLYKLIQRGVPNWFPYNSVAVMQPMYTKSANEKIAKEIGTFDQFTTDDPKPPAKVAVTMSNETIKKVLSNTKQYVVPWLKPLNDLFPGKKEYGWFMLAGDEAKNYQHRADWTKALKKVPNLHDAVHTFIEREGARLIKKESFTFKKGLDQIDIIRDVAIPLNAQLLSDMFYFDMRTDENPDGELGAAELYRSLLDIRVWGVNNNDPGQAWNRRRRAQEGVKRIYDSTKKLVSEVEVARPRGIGLISAVSNRIGAKSYLKKDSLRSCGLKLVEELLAQGSSIDHVTDNLWLTAFGGIGVPVTAFYEVLAFFLRPENASIWAEVQAIAQKGDDATLHAYVAEALRMTSSQRNVRISKTPGEVDGQSIAPGTAVVLMLGEAGRNPKEIPDADKFNAQRKQQEVSAFSYGQHECVAKDVALAFVTGLIKLVADLKELRPAPGQMGTVKTIRVGTEKAYLNDSWSYLGFDASTWKVHFNGHGKGNFEGDRVPTSNTPIQEYYSLLQKRKDELLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJ71</accession>
    <name>A0A1C3YJ71_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T07217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJ71"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07217"/>
    <dbReference type="eggNOG" id="ENOG502S7VK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJ71"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="291" mass="32638" checksum="6EBC18866CD562A7" modified="2016-11-02" version="1">MAKNHPATRVKTERHYSYECKATAQERPYVSRPSRSQQLRNPKLVPKLTNETLNPLEKKEGVADAELAKVDAERARKREREERDDELINSSAKRHRSVSSHSVSTISTGASRSPSPGRDRAGSPRARGRSPHSDNSRGRDDIRSRSRSFSSDRSQSPRIESKRRKSMSGDDRSPEDYDRRNHYRSRDPLPPGRETTSTKQSRRGSSGSRSPYGYRGQRAQGSRSPGPSGRHGERPGPSGTRHGRERPAPRGGFDGKRNGHGGRHQENARERSLSPFSQRLAMTKAMKQGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJ94</accession>
    <name>A0A1C3YJ94_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T06311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJ94"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06311"/>
    <dbReference type="eggNOG" id="ENOG502SU86">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJ94"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="bZIP_sf"/>
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    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="547" mass="60301" checksum="2D13096C0E83EDC3" modified="2016-11-02" version="1">MIASLSSSPPTSMPYSTSPDSHIHNTDNMVRSSSAEPAKSSKRKGTRSVSTLTPSQLARKRANDREAQRAIRARTKEHIDRLERELEELKSKQSRDQTVQELLRRNQALEEELMRLKENMGVSMTSSPYSAPGTTLSVTIPCSVPSPTSNGILTAPSVYDDNLSSGSGAVPSPRGSPFPSGDYSPIPDYGQQYVPLPTNCESWANTVPCPVPSNVSSPSSSADDYSAGYIPTSVPTSLMPSNNTSSSSLGAVGHSHKDVIKMEYEDVESHVSRRRIPPQQPFNAARFPPHLHGSAAAVRLEHVSRLLPPGSVLGPLKDQNQPGACWPVPVLTTPPACRFDELLVGFLQDCRRMATTESLVHTLGPTRIDVRSVFRSHDSHGQLACSPHPITDLIRSLIDTAGMSRLMERLAIFAPLQTMICWLAQPTPERRARLCEDYAPRECQLTTPHPQWLDLVLWGSLREAAIKRQDLYATDEFQRIYFDSLRLVDWPYQPLESLVTDSQTGHVGLTDALTAHAMNGSSWRLNETFTQRYPELSGLVALEQIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJG8</accession>
    <name>A0A1C3YJG8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FGRAMPH1_01T17151</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJG8"/>
    <dbReference type="FunCoup" id="A0A1C3YJG8">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17151"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJG8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="28"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="278"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="538"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SCB64703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="568" mass="62896" checksum="04984E5DEDB8319B" modified="2016-11-02" version="1">MARSRQMSAANRDASRNERQLPPFPTKQMFVLACCRICEPIAFMSIFPYIYYMIQDFNITDDTNKISVYAGMVTSAFTLAEFSTGVLWGRLSDKIGRKPVLLFGLLGTALSVLVFGFAPSLPVALFARALGGLLNGNIGVLQTTVAELVTVKEHQPRAYTIMPMVWCIGSIVGPMIGGALARPCISYPEIFARGTIWDRYPYLLPNLFSACTVFFGVIIGLLFLDETHSEKKNQRDRGREMGDYIASWFGSVTKCNGRDRAPEKQALLDGKHHAQYLSTAPRPGSAHSEDEALPAYRSQENSPRLSPQADTQSLVDAPLEPVLERKPTKTFTKPVIMNIISYGILAFHTMTFDQLFPVFLSTKRPEHPVHDLPFKFTDGFGLETKMIGVIMSVQGLYSLLSNYLIVPPVTRRLGSLRLFRMLAFSYFALYLVTPYLVLLPDSMRMPAIYLLVIWKCTFSTMAYPSNAILLANSAPSKQVLGTINGIAASTASLCRALGPTLSGLLYSWGLQTGYSGLAWWFSGLITIVGAYLSSQITEGGPQEETTLPEEDPLMDESLFTDYDEENSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJZ9</accession>
    <name>A0A1C3YJZ9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FGRAMPH1_01T19331</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <sequence length="318" mass="33946" checksum="1F206B0585B41FF4" modified="2016-11-02" version="1">MSKQYLTTHTVDNAHITDIFSIATTPKAVISGSGSSTLHIHDTTDPSFPLKQSISDAHKLGCHHVCASRNGNVAASAGFGGEVKTWKVNNDTGEWSLSGEIAGASTKPGEAWALALSEDGSYLATTTNDGRINVWDIVDEKKPKIREYETGSAGSGSFGMSVDLSRDGKFTASGHQNGSVYIFNNDTGRVLYSLSGLAKPVRSVAFSPGNTRLAAAGDAGIIAIYDMKHGEHIANLTGHSSWITSLDWSDTGEYLLSGSMDGKVKVWSIERTTCVATHSETDKALWSVKWLPKTVRSEMFCTAGANRSLSFYREATGG</sequence>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Sordariomycetes</taxon>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
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                <person name="Kistler H.C."/>
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    <reference evidence="7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
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                <person name="Sakthikumar S."/>
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                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SCB64730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="663" mass="73273" checksum="21B8EBFF0FD3243E" modified="2016-11-02" version="1">MDLSQRALPRHTHHQPPPPPLANPSPSHLPAQHSNYSPGTVASHPTLPLPGTHPPLSALTPASASTSPASVSHRLPSASASNTSRHPAGDYHPDAEDHDASVTPVDGEEPPKKKQKRNKPTLSCHECVERKTKCDRGRPHCLACIKRQTECRYAHVANLLEETTRSAANGRRMTKPPKKKSGSSGKSPIPNIADRGMSNDPRATSRGAVALSIGLLSNVPYSLPSASNIFGIGSEHPFANYWTCEGGLSEVISVLPDKIQADILLSRYFECVDPVYPMIHRQTFYADYEHFWQMSQQDKSDTDPSFIALIFVMLALGTQFVTSTTSSQERKQTAEFYASASNQALRIASYLSSASLRSIQAMVLIVYFLINDNHASDGWAFAGVLIRQAYAMGLHRDPNIVTPHATLFEKQQRRKLWQAVLLQDTFLTVLLSLPPSATHTDVSVEDLLDDGSSIANSDPTDTAYIRGSWTLANLVQETICSPRSLDLPICSTARHKSKLIADFRAVYRSFPDVFRSWDPDSITALAKTNKRVVRQTLFLTSNYFHNLMLVHASESPDVPVNVRGTLEAAHDAITAFFLLFTLLEIEARVWWVFNHRAFLEALCIGNVLKEATREPGGADMMARDPLLVRAKSDITRMIQIMQIMGKDSEVARTRVQVLSDFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YK64</accession>
    <name>A0A1C3YK64_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T18345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YK64"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18345"/>
    <dbReference type="eggNOG" id="ENOG502SDAA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YK64"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019240">
        <property type="entry name" value="DUF2196"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03833">
        <property type="entry name" value="YwbE family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40069">
        <property type="entry name" value="YWBE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40069:SF1">
        <property type="entry name" value="YWBE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09962">
        <property type="entry name" value="DUF2196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="196" mass="21614" checksum="5F1DB0176B68FE43" modified="2016-11-02" version="1">MNRPNRPRNRQPRPPRQEQNNQRGGSSRPSRAPGTPQQAAGTVPKVHQVIPGASVFIILKDDQPTGEETKGIVQDVLTRGNHPRGIKVRLRDGQVGRVQRMGNTSEATTPAPSDEPRAQATSASSRFTMRYTDVRRDDEFATGPPPRSLADFMPDFEENSTNAPNAGVETVKCPFCDKFEGDEAAVTHHIDREHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKL7</accession>
    <name>A0A1C3YKL7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T22485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKL7"/>
    <dbReference type="STRING" id="229533.A0A1C3YKL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22485"/>
    <dbReference type="eggNOG" id="KOG2448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YKL7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052352">
        <property type="entry name" value="Sugar_Degrad_Dehydratases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004784">
        <property type="entry name" value="PRK06131.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183:SF1">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXY-ACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXYACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="6">
        <location>
            <begin position="58"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="7">
        <location>
            <begin position="389"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SCB65066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="569" mass="60442" checksum="F8891089E24555F4" modified="2016-11-02" version="1">MTDSNNNPINPDYDLDKPITSKVGLRQGLASYGDPHFSLFLRKVFIKALGYSEDALSRPIIGIVNTYSSFNPCHANIPQLIDAVKRGVQLNGGLAIDFPTISIHESFSSPTSMYLRNLMSMDTEEMIAAQPCDAVVLIGGCDKTTPAQLMGGISANKPILHLVTGPMMPGSHRGVRIGACTDCRNNWAKYRAGTLDIEDITAINDELAPTGGTCGVMGTASTMAAILVGLGMMPFAGATAPAVSASRLRIAEATGGLAVAACKDVERLRPQALLTRESFLNAITVLQAIGGSTNAVVHLMAIIGRHPKVAGTITLDTVDEIGRKTPLLVDLKPSGDNYMTDFHNSGGMLALFHQLKPLLHLDAQTVTGRTLGEEIAHQSLIPVPQELSVIQPFDKPLYPASSLVVLRGNLAPGGAVMKASASKYRNLLQHTGRAVVFANSADMAERIDDPDLDVTPDSVLVLQSIGPIGNPGMPEAGMIPIPRKIAAQGVLDMLRLSDGRMSGTAGGTIGLHISPESADPKSPLGIVRDGDVITLDVEKRSLSVDLSDEEIAQRIEEKVKSFEQKDEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKV5</accession>
    <name>A0A1C3YKV5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T22179</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB65053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22179"/>
    <dbReference type="InParanoid" id="A0A1C3YKV5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="181"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SCB65053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="463" mass="50814" checksum="B0398930C6132C67" modified="2016-11-02" version="1">MKGTDNQYSSGSSPNDYALAINRELHVAMSESFIFKKTACSNCHKRKVFQPGHYECSLKEPSSSYHVPSGPSGNVGQCSGSLGCRTRSHERGASYELRADLRVFTNSPHSRKRKHSLRGRPATYTNNSAKSTFSQGVAKTPHDEAQPEPLALVSPEQSELSEIRSEGCSVDQEPGLDQAVPGFWMHIAVGLAHQLGLHKEPSQGPHRGLRRRIWWTIVTRDILISIGVGRPRMINLEDSDVSPPTAADFQEESEGADVFIANIHIVFFVTLIILTNADNPLAAPVTSLIASSFIASMFAEMQEAGDLQRLGPIFAFHSLVAALPLLSAQRVRSVSSRAAADFDKIYSALQELAEKWGSARGLLEPLLAAKQRMHVTAKSSDILEPVTPPLRDLFSEFGSSACSLWWLLQGDATHLHEFDTNADDVRAGDYFRALQGTGEEEEEEAGTSTSRQQDFIPDDTTWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLK5</accession>
    <name>A0A1C3YLK5_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">FGRAMPH1_01T26685</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
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        <property type="protein sequence ID" value="SCB65406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="229533.A0A1C3YLK5"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26685"/>
    <dbReference type="eggNOG" id="KOG3595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YLK5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000122">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
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        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
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        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
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        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
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    </dbReference>
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        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
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        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="6.10.140.1060">
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    <dbReference type="Gene3D" id="1.20.140.100">
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    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
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    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
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        <property type="entry name" value="AAA_9"/>
    </dbReference>
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        <property type="entry name" value="AAA_lid_11"/>
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    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
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    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
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    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
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        <property type="entry name" value="Dynein_2_N"/>
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        <property type="entry name" value="Dynein_AAA1S"/>
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        <property type="entry name" value="Dynein_AAA5_ext"/>
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    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
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        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
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        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
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        <property type="entry name" value="Dynein_heavy_linker"/>
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        <property type="entry name" value="Dynein_heavy_tail"/>
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        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="1922"/>
            <end position="2060"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="2577"/>
            <end position="2731"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="2919"/>
            <end position="3085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="969"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1163"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3167"/>
            <end position="3243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3407"/>
            <end position="3441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="972"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SCB65406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="4330" mass="491612" checksum="7FF49006D5A9BA29" modified="2016-11-02" version="1">[encoded data, 4330 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLX5</accession>
    <name>A0A1C3YLX5_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FGRAMPH1_01T28169</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="229533.A0A1C3YLX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G28169"/>
    <dbReference type="eggNOG" id="KOG4534">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A1C3YLX5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0032931">
        <property type="term" value="F:histone H3K56 acetyltransferase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016849">
        <property type="entry name" value="Rtt109"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF2">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE RTT109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KAT11"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51728">
        <property type="entry name" value="RTT109_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SCB65535.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="521" mass="58638" checksum="D46A5B41677F23C2" modified="2016-11-02" version="1">MANTSSDLGARLASVLPKGHKFTTLHISTPPTKTDPLYSPPPNERPERTYCENHFLAVSIDAPKEQGKQVLVLGIEVFIYTTARSTTLFVSKADSTGYLALLDLPKGTPSPIREICATFVGFLVEKRRRKGIQFVVNLFARAQDQYLFPGSVDNEGKHVLDDRGLIKWWCRVLDPLLGPAPKSTDAPWKSANGYIVVPGLETHETRALTPRKADSAWEFTHPLERISHYYREFDWVPPRCLIPHFPDDPKSRFRDELDEEAASSQAMKNQGSWKSVKTLDMFWEMMAYRQECSSGRMTGFIWLVFDDQEPASKLDDSQSTAPPETPKKQRIVQITPTTTPRKLFPSKEKKDSRIKKKKTKKTLKGPIIARAPRIKRAKHNYLLDRPANTAYYSWTPQGRGERIFDEAAYKRIVGLLLHLDFATLNKAVGSTRRWLSEGGGGGKWGGVVIGTRETPVPTSKDTTGVNNLTNLVKRKRTDSTVDDNQSKVNVLSAGLVKKKPKEESKDVNVLPMGLVRKKPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMI0</accession>
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        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T11469</name>
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    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YMI0"/>
    <dbReference type="STRING" id="229533.A0A1C3YMI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11469"/>
    <dbReference type="eggNOG" id="ENOG502SNV5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YMI0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
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    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB65715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="524" mass="59564" checksum="E58E7777785CFCBC" modified="2016-11-02" version="1">MVVAADDNPGKGKSKGKQYTRSRTGCLTCRQRHQKCDETRPVCGNCLLVQRQCEYPTAVLPLRERRKKFLPGEQQPWTNAVTISRAIGPGTSVATRPISMAYRSDALFHYFYDLEDPFDVAPKERRQSLLSSTMHSSDTLRNTMLIAGLHFAWNTGQLQSFEPTFLFHKIEAMNSVNKFLRNSRMKYAVCVRNIATLCFTECAMGNIIASETHLDGLMRFMDLHRPPHKAPLAESDLDDELANRYVLFSYNFIHGFKSRVEDVLINGSVTKTSQTPSPALVEKLMHEWHKHEVQGLDIRLKSLKMIPFFFSELPPNTKFVDIDGTATAECLATLTATAQLRTQGMDFDDQQMIWQEGAATRLMLAFVGSHIESISTGGRKGSVPNGSRMASSWSGMAAATGLYLHTILRFWNAGEPIEPRLHRRVLLVLQQDLERSRRTSRPLNDLWFWKAFVGAMTVERQVASPARGVLNEMKWIYESFVREWGIMIGTTTWEQARAALSRIVWPEVFHSEGMAQELWYRCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMK7</accession>
    <name>A0A1C3YMK7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FGRAMPH1_01T11295</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YMK7"/>
    <dbReference type="FunCoup" id="A0A1C3YMK7">
        <property type="interactions" value="693"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YMK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11295"/>
    <dbReference type="eggNOG" id="ENOG502S526">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YMK7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14710">
        <property type="entry name" value="bZIP_HAC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044280">
        <property type="entry name" value="Hac1/HY5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46714">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46714:SF6">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0834">Unfolded protein response</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="116"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SCB65699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="408" mass="44242" checksum="2F26F5F6C7DB95B6" modified="2016-11-02" version="1">MEYQQTLPIDKFQNSPTESLMSIPGDGFTSLFDVTTPSATSTMNPMEMMTPKSYTDDQIPSSLPQIKKEEDMSTPSPSPAPEKKTTKKRKSWGQVLPEPKTNLPPRKRAKTEDEKEQRRVERVLRNRRAAQSSRERKRQEVEALEKRNQELEEAFMAAQEANAKLMSELEQIRRSGAVSYSPSVLDSFRVNPSLSQELFGSKHTHEPIDGLVSSNTTVDPTALSPVLSPVAESFEEIAEQEPSNEAKPELTESTSPDLTQLGGDAQVVPSAANLDAANLGLAPALPGDAAFSLGNSDLLPTSIGADRYILENKYLSSSDSSIIGDDNMVGDAPAFNLNDDFDISLWLNDDSAISAESMATSDFAAAIQGLEPKIYEPENQVSSENPIQQPHPGASTQGCDVGGIAVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YNA8</accession>
    <name>A0A1C3YNA8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T15771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    <sequence length="325" mass="36343" checksum="7B582394E4BCB263" modified="2016-11-02" version="1">MTFSRASTMTLGRENLSSHQPQHEERDGPINLGLLNGADSQSLEKRLIIAIDFGTTYSSVSYVEIPEDCPSDSVDSRSICSIARYPESTDFNSDDRMLREVPSEVIYPLDRHFRDRHALIRSQEGLGNEPGDEDQEESIPDVTNNGLRDVEPLDDDGDTTMDMDVSGQFHWGYGVHELRAIPAMHSDPTNLPLSRFKLLLDDSPMTAKVRQGLNIPLDKLKSRKVVDGPLHVIADYLTYLLDHTRSELRSLGYQDSCPKEMVLCVPAIWSQQACRDMQKCLAVAMKGANFRGADVQNNSIENLFIVSEPEAAAAYMLDNSPEIRV</sequence>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblFungi" id="CEF72014">
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            <dbReference type="EMBL" id="CEF72014.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316315.1">
        <property type="nucleotide sequence ID" value="XM_011318013.1"/>
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    <dbReference type="AlphaFoldDB" id="I1RAT8"/>
    <dbReference type="EnsemblFungi" id="CEF72591">
        <property type="protein sequence ID" value="CEF72591"/>
        <property type="gene ID" value="FGRRES_00624"/>
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    <dbReference type="KEGG" id="fgr:FGSG_00624"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01581"/>
    <dbReference type="eggNOG" id="ENOG502SRTS">
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    <dbReference type="HOGENOM" id="CLU_927639_0_0_1"/>
    <dbReference type="InParanoid" id="I1RAT8"/>
    <dbReference type="OrthoDB" id="5106185at2759"/>
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        <property type="component" value="Chromosome 1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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            <begin position="20"/>
            <end position="300"/>
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            <begin position="19"/>
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            <begin position="239"/>
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            <begin position="24"/>
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        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EnsemblFungi" id="CEF72591"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="300" mass="34479" checksum="B509F25AC40ABD0C" modified="2012-06-13" version="1">MKLYQVTAVLAFITTGVIATPSGYDKDNKSPEKHSDDNYPGKKGDDEYGSGGKGYGGKGREDKGKKHEWDIERCDWCPYNPKSWYGYEPKGHIYKRPCPEDKKKCQKYAYDYSKATYSGVFSEFQKCSKGDNYKVTGKVGACSGYGKVQCLIVQYEDWEKWSDKIAYLGLYSYKKESPKDKKYLNFNKYCKKNKCVVPIEKVPGYPKFKDNVWVGIDDDQCREDYKKGNKENDYEYKKGGKGDYDSKKRGNGGDYDDDEVEEYKKGGKGSSRGRYEEVKYLELNIEAKYSKKCAEFCCCA</sequence>
</entry>
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    <accession>I1RB53</accession>
    <name>I1RB53_GIBZE</name>
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        <name evidence="6" type="primary">FG00760.1</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316471.1">
        <property type="nucleotide sequence ID" value="XM_011318169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RB53"/>
    <dbReference type="STRING" id="229533.I1RB53"/>
    <dbReference type="EnsemblFungi" id="CEF72759">
        <property type="protein sequence ID" value="CEF72759"/>
        <property type="gene ID" value="FGRRES_00760"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00760"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01917"/>
    <dbReference type="eggNOG" id="ENOG502S58E">
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    <dbReference type="HOGENOM" id="CLU_050545_0_0_1"/>
    <dbReference type="InParanoid" id="I1RB53"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="RBD_domain_sf"/>
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    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
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    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
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    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
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    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="15"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="156"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="256"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF72759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="287" mass="32439" checksum="F55F48D2C1166C55" modified="2012-06-13" version="1">MEQEAIAAGRRIYLGTIIPSNLPYEAKPFEVEEVLAKNGFDRLDKIHISVDPVSARNPGYCFVDFHDRETAERALSSLYATVYGRTLKVGPCEPKKPRERRGFQNEDATSRRWGDWNAKSSANGNSLGHTNGRGENRGPNWAIDHFEDVIRDQGGRRLYVGGLDKMVDQAQHQEELAQIFYGFKPAAIGKRITPHESKRTLPGNHHYCFVDFETKEEASSAVEQLNGKMIQGGQLKVSVSERIPQKLVGRQLDAREGRQVADRVNNPRPNKPETNNAMVSNNWRRKD</sequence>
</entry>
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    <accession>I1RBW4</accession>
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    <gene>
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        <name evidence="5" type="ORF">FGRAMPH1_01T02639</name>
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    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_011316812.1">
        <property type="nucleotide sequence ID" value="XM_011318510.1"/>
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    <dbReference type="STRING" id="229533.I1RBW4"/>
    <dbReference type="EnsemblFungi" id="CEF73121">
        <property type="protein sequence ID" value="CEF73121"/>
        <property type="gene ID" value="FGRRES_01055"/>
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    <dbReference type="KEGG" id="fgr:FGSG_01055"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02639"/>
    <dbReference type="eggNOG" id="KOG2190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022670_4_0_1"/>
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    <dbReference type="OrthoDB" id="1937934at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22439">
        <property type="entry name" value="KH-I_PCBP_rpt3"/>
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    <dbReference type="CDD" id="cd22455">
        <property type="entry name" value="KH-I_Rnc1_rpt1"/>
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    </dbReference>
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        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
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        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="111"/>
            <end position="181"/>
        </location>
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    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="194"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="395"/>
            <end position="465"/>
        </location>
    </feature>
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            <begin position="1"/>
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    </feature>
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        <location>
            <begin position="292"/>
            <end position="391"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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    </feature>
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            <begin position="27"/>
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            <begin position="376"/>
            <end position="391"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF73121.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF73121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="474" mass="49660" checksum="B36B68164BC13DB5" modified="2012-06-13" version="1">MSASPTQPTQSAKRPLEEASSPSRAGDQPDAKRPTLEKIKHDDDDDVEVPEAPVDIPADDHDDKVNGAAKSEDDDDTAPDPASDAKAAAAATVAASSSNAVTSAAAHDETSWIHVRAVISSPEAATVIGKGGENVSNIRKLSNAKCTVSDYQKGAVERILTVSGIVDAVAKAFGLIIRTLNNEPLNEPSTASSKTYPLRLLIPHILIGSIIGKGGARIREIQDASGARLNASDSCLPMSSERSLVVMGVADAVHIATYYVGSTLLEQLNDRFGGPAASAYATRSGAPAGSIPGGMQVVPYSPQPSSGHYGRSENYGRHNDRRSHHMPPAPYPQQYPPHAAAQANPAMPMHYGGAQGGGAYGAAPHAQPHMPPHTGPQPHGGAPQAQPMGGAIPGGPITQQIYIPNDMVGAIIGKGGQKINEIRQMSNSVIKINEPQDNSNERLVTITGTEECNRMALYMLYSRLGEVQNKSSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>I1RCM7</accession>
    <name>I1RCM7_GIBZE</name>
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        <recommendedName>
            <fullName evidence="3">Apurinic-apyrimidinic endonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG01348.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T03325</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CEF73467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317139.1">
        <property type="nucleotide sequence ID" value="XM_011318837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RCM7"/>
    <dbReference type="FunCoup" id="I1RCM7">
        <property type="interactions" value="47"/>
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    <dbReference type="STRING" id="229533.I1RCM7"/>
    <dbReference type="EnsemblFungi" id="CEF73467">
        <property type="protein sequence ID" value="CEF73467"/>
        <property type="gene ID" value="FGRRES_01348"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01348"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03325"/>
    <dbReference type="eggNOG" id="KOG3997">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="I1RCM7"/>
    <dbReference type="OrthoDB" id="7663182at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="Probable endonuclease 4"/>
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    </dbReference>
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        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Nfo"/>
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        <property type="entry name" value="AP_endonuc_2"/>
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    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
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    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
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        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
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        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002199">
        <property type="entry name" value="PRK01060.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="10">
        <location>
            <begin position="126"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="52"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="411"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF73467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="456" mass="49727" checksum="03EC190F35F6459D" modified="2012-06-13" version="1">MVRTSLRNKQTVNYNEDHNDDKMPKAKVAARAITTASKIVENANGVASKSVAAKAITKRKAEPEAEPENAAPAPAVKAAKKRKTKAKDEDATPLADRTAISTLKPAMHIGAHVSAAGGVQNSVTNAIHIGANAFALFLKSQRKWANPPLDSEAKNQFISLCKDHSYSANEHALPHGSYLVNLAQADEDKANQAYTSFVDDLQRCEQLGIRLYNFHPGSTGGDARPAAIGRIAAQLNKSHKATKTVVTVLENMAGSGNVIGSTWEDLRDIIELVEDKSRVGVCIDTCHAFAAGLDLRTPEAFKKTFDSFNEIVGHEYLKAFHLNDSKAPFNSKRDLHANIGTGFLGLRAFHSIMNHAPFAGMPMVLETPIDRPGADGKSVEDKKVWADEIKLLERLVGMDAESDEFKELEIELQSKGESERNKIQDQVDRKLAQDAKKGTKKGGKKKKKKDESDESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1RDB5</accession>
    <name>I1RDB5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG01609.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T03933</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317432.1">
        <property type="nucleotide sequence ID" value="XM_011319130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RDB5"/>
    <dbReference type="EnsemblFungi" id="CEF73773">
        <property type="protein sequence ID" value="CEF73773"/>
        <property type="gene ID" value="FGRRES_01609"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01609"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03933"/>
    <dbReference type="eggNOG" id="ENOG502RKMG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_637846_0_0_1"/>
    <dbReference type="InParanoid" id="I1RDB5"/>
    <dbReference type="OrthoDB" id="5039224at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF73773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="481" mass="55787" checksum="3267FD1E46B7A7BC" modified="2012-06-13" version="1">MSLQQSNNQSRPVHTCILAMLPAEVIYEVIDAFRRNPYDPDDPRAGLDSLDQTSPRLRSLSLVRPVFFRASNFKQLFQSLRVANATMMDRCEYCDAAPIYKLWPRPHVVPLEFMELLLGGVHEVSSRCDNRLGARARDKISNGLKWLFERGTDGETTNRSWARSSESFDHMSKNLLARLRRGSSKRGMETIFKTMKMLSIHGYPVPTRDDTFPGQVIPDADEWRHDSKRSYRTSSPLSIALKSHVTPSILELMLSEHADRGIKLTDWYDECPTSLVKLATQEDTWGVSVNWTEVSYVDRLIGILHADLHKKWTGWEEEYFGEVADIFQAKLKLMIKYEMIDTSEEALLKSIGSALYSIAADGMQAGGYDQEHIKRSWEKLCDAVKPFATDANLVEDPNGIQLPNAPRRIHRFAIHPEWNPWESWFRRQDEIRREEWKDMRFWHATTKRFKPMQYDRATSLGVPEWHTVSMDEWDAFFPRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1RET3</accession>
    <name>I1RET3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG02184.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T05265</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318071.1">
        <property type="nucleotide sequence ID" value="XM_011319769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RET3"/>
    <dbReference type="EnsemblFungi" id="CEF74437">
        <property type="protein sequence ID" value="CEF74437"/>
        <property type="gene ID" value="FGRRES_02184"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02184"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05265"/>
    <dbReference type="eggNOG" id="ENOG502SHR6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011409_11_2_1"/>
    <dbReference type="InParanoid" id="I1RET3"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF13">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN MOC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF74437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="449" mass="50684" checksum="9F26114D412A8CD5" modified="2012-06-13" version="1">MKCDGYPPPKPPKPPRKRTKAKTASVKLVPIPLGTSIHDVPTLTSHECQYFQHFLQLTSTQLSLSAESTNFWIRFVLPLGHKHESIRYSVAAVGASHRLFMARANGHPNIGEIQNFMIQQYNKAISSIIPNMTQSCTENLHVVLICCLLFISFEGLTGRYDEFIKHLRAGSALFNSKLPSSTFEDRMITEKLAEMFCRLQVESANFMPINEGASGVERWYRNNAIQGSQSVAPFNSLNEASLVLRQLDVLQDEKPWHYEGSDGVDKERLMTEASQRLQKSLDEWTARLDAFCNLRAEGLSAREEQQYDNLCLRQKYWQMVIDSYEGMSGKAGPSPKLFEPFLVAARKAASPIIALQQPTYSLEGDLISGLTFIASSAEDEEVKVQALDLLWRLNRREGLLDSRDVVEMHELSRALSQLTVTPTVDEHWKPKAPAGIPSIIERLRKYLEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-08-30" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RF54</accession>
    <name>AURR1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aurofusarin biosynthesis regulatory protein aurR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Aurofusarin biosynthesis cluster protein R1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Gibberella pigment protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aurR1</name>
        <name evidence="7" type="synonym">GIP2</name>
        <name type="ORF">FG02320</name>
        <name type="ORF">FGRAMPH1_01T05585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Fungal Genet. Biol." volume="42" first="420" last="433">
            <title>Identification of a gene cluster responsible for the biosynthesis of aurofusarin in the Fusarium graminearum species complex.</title>
            <authorList>
                <person name="Malz S."/>
                <person name="Grell M.N."/>
                <person name="Thrane C."/>
                <person name="Maier F.J."/>
                <person name="Rosager P."/>
                <person name="Felk A."/>
                <person name="Albertsen K.S."/>
                <person name="Salomon S."/>
                <person name="Bohn L."/>
                <person name="Schafer W."/>
                <person name="Giese H."/>
            </authorList>
            <dbReference type="PubMed" id="15809006"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2005.01.010"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="Mol. Microbiol." volume="61" first="1069" last="1080">
            <title>The biosynthetic pathway for aurofusarin in Fusarium graminearum reveals a close link between the naphthoquinones and naphthopyrones.</title>
            <authorList>
                <person name="Frandsen R.J."/>
                <person name="Nielsen N.J."/>
                <person name="Maolanon N."/>
                <person name="Sorensen J.C."/>
                <person name="Olsson S."/>
                <person name="Nielsen J."/>
                <person name="Giese H."/>
            </authorList>
            <dbReference type="PubMed" id="16879655"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2006.05295.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2006" name="Appl. Environ. Microbiol." volume="72" first="1645" last="1652">
            <title>GIP2, a putative transcription factor that regulates the aurofusarin biosynthetic gene cluster in Gibberella zeae.</title>
            <authorList>
                <person name="Kim J.E."/>
                <person name="Jin J."/>
                <person name="Kim H."/>
                <person name="Kim J.C."/>
                <person name="Yun S.H."/>
                <person name="Lee Y.W."/>
            </authorList>
            <dbReference type="PubMed" id="16461721"/>
            <dbReference type="DOI" id="10.1128/AEM.72.2.1645-1652.2006"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2007" name="Biochem. Biophys. Res. Commun." volume="363" first="639" last="644">
            <title>Involvement of the osmosensor histidine kinase and osmotic stress-activated protein kinases in the regulation of secondary metabolism in Fusarium graminearum.</title>
            <authorList>
                <person name="Ochiai N."/>
                <person name="Tokai T."/>
                <person name="Nishiuchi T."/>
                <person name="Takahashi-Ando N."/>
                <person name="Fujimura M."/>
                <person name="Kimura M."/>
            </authorList>
            <dbReference type="PubMed" id="17897620"/>
            <dbReference type="DOI" id="10.1016/j.bbrc.2007.09.027"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4 5">Transcription factor that specifically regulates the expression of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15809006, PubMed:16461721, PubMed:16879655).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4 6">Expression correlates with aurofusarin production and is restricted to vegetative mycelia (PubMed:16461721). Expression is negatively regulated by the MAPK-mediated osmotic stress-signaling pathway (PubMed:17897620).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4 5">Leads to an albinos phenotype (PubMed:16879655). Inactivates the expression of the aurofusarin biosynthetic gene cluster (PubMed:16461721, PubMed:16879655).</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318229.1">
        <property type="nucleotide sequence ID" value="XM_011319927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RF54"/>
    <dbReference type="SMR" id="I1RF54"/>
    <dbReference type="STRING" id="229533.I1RF54"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T05585">
        <property type="protein sequence ID" value="FGRAMPH1_01T05585-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G05585"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02320"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05585"/>
    <dbReference type="eggNOG" id="ENOG502SUCM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051725_1_0_1"/>
    <dbReference type="InParanoid" id="I1RF54"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="PHI-base" id="PHI:1973"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045122">
        <property type="term" value="P:aflatoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013700">
        <property type="entry name" value="AflR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08493">
        <property type="entry name" value="AflR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000441084" description="Aurofusarin biosynthesis regulatory protein aurR1">
        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Zn(2)-C6 fungal-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="15809006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16461721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="16879655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="17897620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="16461721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="16879655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF74597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="398" mass="43142" checksum="29A0508B096E2EE6" modified="2012-06-13" version="1">MSSTDPLLRRVENYRESCDNCAKSKVRCGKEQPWCQRCERRGQVCSYSPSQRSRKRTLDAAHPESDQRNGTPPFTAISSASSVAAVSTGFSSMLSQADSWGTCPDLVELLTSGSSSESLTPDNNHLVWLSDMESIAGDSNISKSMERMDVFPYPKSIASSAAGVVNGSGAGADSMGRRSTCPLQNKQHCEADLISALAKPELPSLSCWGNPKASQNLGTILTASRATLKCVTTAMSCTCTPNDNVALLATAVLLRILSWYHIVLKNCNGPNDTSAATIDDHTSPTPSNDGKDTERSVSRDTNVSQDGSEPSSLIMPPMTIGAYELDSENRERMIGHIMLSELGKMGNLLSDFSKKFCDPQSTMLGNDNRSQLFLALEMLIRNKHMATVLDVRKKLEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>I1RFS5</accession>
    <name>I1RFS5_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial-processing peptidase subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-MPP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Inactive zinc metalloprotease alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Matrix processing peptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">FG02563.1</name>
        <name evidence="14" type="ORF">FGRAMPH1_01T06145</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318501.1">
        <property type="nucleotide sequence ID" value="XM_011320199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RFS5"/>
    <dbReference type="FunCoup" id="I1RFS5">
        <property type="interactions" value="1056"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RFS5"/>
    <dbReference type="EnsemblFungi" id="CEF74877">
        <property type="protein sequence ID" value="CEF74877"/>
        <property type="gene ID" value="FGRRES_02563"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02563"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06145"/>
    <dbReference type="eggNOG" id="KOG2067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_5_2_1"/>
    <dbReference type="InParanoid" id="I1RFS5"/>
    <dbReference type="OrthoDB" id="277191at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017087">
        <property type="term" value="C:mitochondrial processing peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000023">
        <property type="entry name" value="Mitochondrial processing peptidase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000032">
        <property type="entry name" value="Mitochondrial processing peptidase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="12">
        <location>
            <begin position="59"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="13">
        <location>
            <begin position="212"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="261"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CEF74877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="565" mass="61441" checksum="A9D0173099A30782" modified="2012-06-13" version="1">MLRQFSAGLPKARASCSKVLGQASKFSMARRSMATVKVKGIEKDPTELDKVTTLPNGLRVASEALPGSFAGVGVYIEGGSRFENDSLRGVSHIMDRLAFKSTSKRSADDMLEQVEALGGNIQCASSRESMMYQAATFNNAVPQTIELLAETIRDPQITDLEVAEQIETARYEIREIWSKPELILPELVHTAAFKDNTLGNPLLCPEDRLGSIDKNTVMAYRDLFYRPERMVVAYAGIEHSEAVRLTEKFFGDMKKGARQITEATGSETSESELSDSEASASSASSSPQQSSGLLSRFFKNTPSAPQNLNNLPSQADIIRPSKYTGGFSWLPAQPPNLSGLPTFTHIHLAFEGLPVSSDDIYALATLQTLLGGGGSFSAGGPGKGMYSRLYTNVLNQHGWVESCMAFNHSYTDSGLFGISASCLPGRTAAMLDVMCQELRALTLTTGFSRLQETEVARAKNQLRSSLLMNLESRMVELEDLGRSIQVHGRKIPVKDMCRRIENLTVADLRRVATMIVGGQVKNPGGGSGAPTVVLQEAQAYGVSSHTMSWDQIQDRIDSWKLGSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>I1RFZ3</accession>
    <name>I1RFZ3_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="14">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">FG02640.1</name>
        <name evidence="19" type="ORF">FGRAMPH1_01T06337</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="20">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="21">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="20">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="19 21" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="19">PH-1</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="14"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318590.1">
        <property type="nucleotide sequence ID" value="XM_011320288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RFZ3"/>
    <dbReference type="FunCoup" id="I1RFZ3">
        <property type="interactions" value="997"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RFZ3"/>
    <dbReference type="EnsemblFungi" id="CEF74973">
        <property type="protein sequence ID" value="CEF74973"/>
        <property type="gene ID" value="FGRRES_02640"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02640"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06337"/>
    <dbReference type="eggNOG" id="KOG0944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009884_1_0_1"/>
    <dbReference type="InParanoid" id="I1RFZ3"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14385">
        <property type="entry name" value="UBA1_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14386">
        <property type="entry name" value="UBA2_UBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000086">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000396">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000587">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000235">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000144">
        <property type="entry name" value="Ubiquitinyl hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF664">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 14" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 14" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="18">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="18">
        <location>
            <begin position="150"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="17">
        <location>
            <begin position="301"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="16">
        <location>
            <begin position="578"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="16">
        <location>
            <begin position="640"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="680"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="728"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CEF74973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="774" mass="85448" checksum="025F203A4C35DE55" modified="2012-06-13" version="1">MACPHLDLIGLTPPDPSQSVYREDCTQCFDSIDDPDGLDVCLQCFNGGCAGERNHDRLHYALTQHPLALNIRRTRKVVERDEPPAKMSKLAIAAETEEDRYDTALAVKCLDCNTELDRTNPKLAPMVDGILKANTFSRKEEVKAWEQELTSCEHILMLQQAPSKKIEQNDLSHCYACDLAENLWLCIECGNLGCGRKQMGGVDGNSHALAHSNESGHGVAVKLGSITPEGTADIYCYKCDDERVDDKLGEHLNHWGIVLAERQKTEKSLTEMQIEQNLKWDFSMTTEDGKELKPLFGPGLTGLRNLGNSCYLASIVQCLFDMPSFQSRYFQPGADLPIVPEPAADLETQLRKVADGLLSGRYSKPDTEIAREAATHQKGLAPAMLKHLIGRGHEEFSTMRQQDALEFLQHLFKLITRSSHSDGKDPTEPFRFVLEQRLQCLGCHKVKYSSNEQDNIFIDVPLEKLPREEGSDGPDAYKPVSLTQCLDNFTAAEKVELTCSACGSKDGFSKQSLFKTFPDTLVVNARKMTVVNWVPIKVDVPVLVPDKPFNLDAYLSKGLQPGEEQLPDEPEAKAPAFEPDATAMSQLEAMGFPYNRCARALHATGNSDANTAMEWLFGHMEDPDIDAPLDLGAQTGAADTADPEKIETLGAMGFGAPQAKKALKETGGDLERAVEWLFSHPDDQGDDDAPAEGASSATKEPAGSADLPATFQLRSIVCHKGTSIHAGHYVAFIRKALGDANVPTWVLFNDEKVVEAHDVDEMRKFAYVYFFKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1RGV0</accession>
    <accession>A0A098DFI6</accession>
    <name>I1RGV0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG02979.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T11759</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322814.1">
        <property type="nucleotide sequence ID" value="XM_011324512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RGV0"/>
    <dbReference type="EnsemblFungi" id="CEF77683">
        <property type="protein sequence ID" value="CEF77683"/>
        <property type="gene ID" value="FGRRES_02979"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02979"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11759"/>
    <dbReference type="HOGENOM" id="CLU_147505_1_0_1"/>
    <dbReference type="InParanoid" id="I1RGV0"/>
    <dbReference type="OrthoDB" id="3660917at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="114" mass="12655" checksum="345FD78DF28274ED" modified="2012-06-13" version="1">MTPQSASIDDIPECRFPPDSERVEYKDLDSAQKQLSEILHTVKQDPTLKDISHLGSEGIYHCLITDRHVVNAIPLTSPLIKDLVGQLPYSEESEKKFHGVNGTRSGSKKARSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1RGX7</accession>
    <name>I1RGX7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T11837</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322780.1">
        <property type="nucleotide sequence ID" value="XM_011324478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RGX7"/>
    <dbReference type="EnsemblFungi" id="CEF77721">
        <property type="protein sequence ID" value="CEF77721"/>
        <property type="gene ID" value="FGRRES_03009"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03009"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11837"/>
    <dbReference type="eggNOG" id="ENOG502R3ID">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_2_1"/>
    <dbReference type="InParanoid" id="I1RGX7"/>
    <dbReference type="OrthoDB" id="5393606at2759"/>
    <dbReference type="PHI-base" id="PHI:5834"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF114">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06620)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="25"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF77721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="356" mass="38698" checksum="3A52187D848F11BB" modified="2012-06-13" version="1">MESRGPTVNSVAIVFAVISFLAVVLRLWARAFIVRSVGKDDYLICVGALLSWSFIACTIASVNHGLGSHFEDVNKLGTDNLIAYSQIVWLSSIFYNACLGFIKISVLALYTRLGDKVLRKAAFFMMVVVGCQAGGNVLACIFQCTPISGAFDVRIPASEKKCVNINAFYLANAAVNIFTDILTYSLPIPLVIRLRVPRRQKISLAIILGLGLFACISSIIRITYIPPMLTSTDPTWVISNAMYWSVIETNIGILAASIPSYKAIAKKYAPRLLGSTGISSNKLSGFKQMPVELRGNSVPGNGAPKSTFETNIKNGLDSNSSEEVLVMPSGQIGVKTDIVFRYEQNLEDGQGHGRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1RI16</accession>
    <accession>A0A098DJY9</accession>
    <name>I1RI16_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG03436.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T12877</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322283.1">
        <property type="nucleotide sequence ID" value="XM_011323981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RI16"/>
    <dbReference type="STRING" id="229533.I1RI16"/>
    <dbReference type="EnsemblFungi" id="CEF78241">
        <property type="protein sequence ID" value="CEF78241"/>
        <property type="gene ID" value="FGRRES_03436"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03436"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12877"/>
    <dbReference type="eggNOG" id="ENOG502S5K7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050230_0_2_1"/>
    <dbReference type="InParanoid" id="I1RI16"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF19">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="8">
        <location>
            <begin position="21"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF78241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="227" mass="25086" checksum="79BA9D022438A1DE" modified="2012-06-13" version="1">MLFNLLFLCSAVLAHHHSADDSNEWHGPSKWDRRSPCPMVNSLANHGYLPRDGLNITLDDLIEGFTDAINLDPAATTLVGKKALDTGDGTSFNLDDLAKPGILEHDGSLSRDDIYFGDNSRLDPHIWKSTLQHFRAPYISIQEAADARKDRLQVAAANNPEFSMTAEQNKISLIETSLYLTVFGNPEEGNANTHWVRTLFEGFQRSENPIIVAQILGMVNKVAQASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1RIG5</accession>
    <name>I1RIG5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG03597.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T13247</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321937.1">
        <property type="nucleotide sequence ID" value="XM_011323635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RIV7"/>
    <dbReference type="STRING" id="229533.I1RIV7"/>
    <dbReference type="KEGG" id="fgr:FGSG_03752"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13627"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070656_0_0_1"/>
    <dbReference type="InParanoid" id="I1RIV7"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.220.160">
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    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF292">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="35"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB65849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="358" mass="40760" checksum="9E59B0547228C110" modified="2012-06-13" version="1">MEFQKPSLPPKAPRTNALKASNVANTHDLDFYVHPHLVPDQDPCKGRLLRATGPIREGTILLVDTAYAIVPSVTSDAEPLICSNLSCSRRVPQNGRAVRCENACFKDVVWCNIACRASDKLRHDYECAWLKKNADSMRRKESEYNFATLWHVVRLLATWNAELHSGNAVAQHRYPWEAHFLRGWKAVDMCCAYLDSWPEEQLTHWKRLVNEYLSDTSVLPCMLTADDMLLLLCKEETNTFGLYPKATGTQFVNDNATSRGESYGFALYPRAAQFNHSCLPNVSHKPDGQARMVYTAARDISKGEECMITYFDLATRKDVSSRQKYAQTQFQFKCTCNRCLEEEADENMDIMDSLPFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJR5</accession>
    <name>I1RJR5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">FG04095.1</name>
        <name evidence="15" type="ORF">FGRAMPH1_01T14473</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321545.1">
        <property type="nucleotide sequence ID" value="XM_011323243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJR5"/>
    <dbReference type="FunCoup" id="I1RJR5">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF79040">
        <property type="protein sequence ID" value="CEF79040"/>
        <property type="gene ID" value="FGRRES_04095"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04095"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14473"/>
    <dbReference type="eggNOG" id="KOG4505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008635_0_0_1"/>
    <dbReference type="InParanoid" id="I1RJR5"/>
    <dbReference type="OrthoDB" id="2190219at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097623">
        <property type="term" value="P:potassium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013928">
        <property type="entry name" value="Cation/H_antiporter_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08619">
        <property type="entry name" value="Nha1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="407"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="26"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Alkali metal cation/H+ antiporter Nha1 C-terminal" evidence="14">
        <location>
            <begin position="458"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="457"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="714"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="464"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="782"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="830"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="844"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="886"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CEF79040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="941" mass="104083" checksum="E2944F92906B1BD8" modified="2012-06-13" version="1">MAWSHLDITKPHLVYIILGGFTSLFMLCSSVIKERMYIGEATVATLCGVIFGPHAANLIDPQSWGSTDIVTVEFSRIVLVVQCFAVGVELPKFYMERHWKSVVFLLIPVMTFGWLITSLFIFWMIPPLDWLDSLVVAACVTATDPVLASSVVGKGKFAKRVPKHLRDLLSAESGCNDGMAFPFIYLSLYLIQFKRDAQDVSFHFVVYVLLYECIFGAIYGFVIGYIARHGIRYAEKRDLIDRESFLVFYFVVALWCAGSGSILGMDDLLVGFAAGVGFSNDGWFGEKTEESHVSNVIDLLLNLTYFVYFGTIIPWEQFNNGVFGLVAWRLVVIAIFVLLFRRIPIMLALKPFIPDVKTWREALFAGHFGPIGVGAIFVAILARAELEHEEPVPLAQLPPENTEHYDLIYLVWPIVSFLVVTSILVHGSSIAVFTLGKRINTLSLTMSYTAAPEDGPSWMNRLPRISSQSRSQARSISEASIDEEKGPQFPPDAAIPNSGPYSHLLRRQRDQNGSRSPSVVSRKRKNKNWDEDRGPGGPIAQSAIFPQRQSSTPMSPNEQHDQEEFPSQDNTESTLAADDSSKERNSDRIEQAGESPVGSSGQKTPPQPVSIYEEGHEMIFENQDGDVLDVEPAPDSHREDENHVPITAVKPGHDKLWTVAGFKKRVGEVYNTEMEKRKDKGQDRRHEPARAYQFGNTIIVEDADGEVVKTYELPAAKGGDSEAGPSTPGEKPAGKHGWANFGGVFGGNHGNEQNNRKKSVAETQAADDKAIRFTIGGVGQRMTKEDFIREVQKLDSRTRKEVVEQSDASQAVKKVAKQDLPPETAVKAAKAAEHHAPENRKGRSGSSASAAAPSSPAKPSEQQAETAIERKRRLAALSSQEEEPKEETTETPAERRRREAALGVGNQADDSDDEGTERVPPNRRGITFADSTRPGRGRRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I1RK38</accession>
    <name>I1RK38_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG04226.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T14779</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321399.1">
        <property type="nucleotide sequence ID" value="XM_011323097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RK38"/>
    <dbReference type="EnsemblFungi" id="CEF79191">
        <property type="protein sequence ID" value="CEF79191"/>
        <property type="gene ID" value="FGRRES_04226"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04226"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14779"/>
    <dbReference type="eggNOG" id="ENOG502SDAI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069416_0_0_1"/>
    <dbReference type="InParanoid" id="I1RK38"/>
    <dbReference type="OrthoDB" id="3692311at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF27">
        <property type="entry name" value="CHITIN-BINDING TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF79191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="344" mass="37047" checksum="188A76F33D0B4B78" modified="2012-06-13" version="1">MSEAREYWGLSCINGGKFYICEDDDTQFIGCCLNDPCGKNNGTCPDGDLRATTFESDKYAKLPAQDCDNSQGVDNWYTCAFTNPPFLGCCSQNACGSGCPRDRLVPAKLSEIENNRLDFLNPRSDESTTASSASETASATASSTSTVNANDDDGLGTGAMAGIAVGASIGGLFVLGLLAWLFWLRPRQKKKKNEKALQAASTASAPGPTMSEQPHSPMGGPIHQGTFAAHSPMSGYQQSFNSTPTVMNPHYSGVSSNDQYQKYSPQFSQSERPQSYAQFSDHGSYANSPGLPPYQQPQMIPVQEMDGTTTARQEMDAGPEHHIQRNPSIGPEILNVQQPKPETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1RK39</accession>
    <name>I1RK39_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG04227.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T14783</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321398.1">
        <property type="nucleotide sequence ID" value="XM_011323096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RK39"/>
    <dbReference type="STRING" id="229533.I1RK39"/>
    <dbReference type="EnsemblFungi" id="CEF79193">
        <property type="protein sequence ID" value="CEF79193"/>
        <property type="gene ID" value="FGRRES_04227"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04227"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14783"/>
    <dbReference type="eggNOG" id="ENOG502S8IP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071330_0_1_1"/>
    <dbReference type="InParanoid" id="I1RK39"/>
    <dbReference type="OrthoDB" id="3535423at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF9">
        <property type="entry name" value="EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF79193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="231" mass="25314" checksum="88F9520A806B09CF" modified="2012-06-13" version="1">MKVVVTGATGLVGNDIVKQCLSDARITKVVILTRKAVTMDIESHPKADVIMVQDFSRYSDDLLRRIEGSSACLWAIGARPDHSHSHSHKDKTYLHHVNVQLPLYAAKIMSERIAPKTPGGQKFNFVFASSKSRSSSLLSLGDPRKPKAEAEKGLCEIADASPETFSAWILRPSTILSASSDVAPKKRRLVGGRSNVGVEASHMAKAFVKVACEGYRERVIDNEAILKMKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>I1RLT2</accession>
    <name>I1RLT2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG04901.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T16597</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323370.1">
        <property type="nucleotide sequence ID" value="XM_011325068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RLT2"/>
    <dbReference type="STRING" id="229533.I1RLT2"/>
    <dbReference type="EnsemblFungi" id="CEF87434">
        <property type="protein sequence ID" value="CEF87434"/>
        <property type="gene ID" value="FGRRES_04901"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04901"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16597"/>
    <dbReference type="eggNOG" id="ENOG502RZ2S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006926_1_2_1"/>
    <dbReference type="InParanoid" id="I1RLT2"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="PHI-base" id="PHI:1956"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
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    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
            <begin position="294"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="605"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF87434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="696" mass="78363" checksum="9D58B0544E803EA0" modified="2012-06-13" version="1">MSTRRPRRLLAACHSQKIKCSGDKPCQSCSSTGRAGECEFPANKERKIPVSESYLKKLEDDSRKLQAIASHNQTPETEPAFTPLNSQSQNDYDPPSLSKEESNLFNPLFDRQPEKPIQERSSEPGFIGEASCAAFSNRLLSCLDDTYTPSTAGLSNYHKLSTYAKLPAAQGSEFPERMHVKLLLNVARRFIGNYHPLFLEVTFMKEIDAVYRREMVPSSLWLCKFYALMALGEIYTHRRGVGDNNRVPGTNYYVRAVSLLQENQDYYEEPSLMQVEVLTLLAWASNVLGRIRTAYCYSGIAMRLAQSLGMHRSASRHTTLTPVERESRTRTWWVLYFFDRFSASKLGQPITVRDEDIDVEMPSQEGLTKDEMAEFLDPQNLITNIRLARIIGNICESSSSNNFAWANRLPVTHIYGIPKATNGLYIHQVHGILKQLREWHDELRTDMRVKERGTPRPVASLHLAYYQCIIQTTRPVLLHLFKTQFQLGTKPRDDAQPRQNVSSITLALAESCVNAAQASSRIVEGLFLDGSIATFGYWDAHHIFSAAMILIMSAVMKPTAVNSDHLETLLSVLRSLKNDGNIPAVDFCERLSHIQTRVSTLRATGRLDGVPPTTRPPSPNENLDSSGQNQPFQTPMSMDTECNTGVVGYDDVDILGNPLIGSFLDGNQVQWLDVLFAEDGTLKEFASEIEDQFLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1RME1</accession>
    <name>I1RME1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG05130.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T17173</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323628.1">
        <property type="nucleotide sequence ID" value="XM_011325326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RME1"/>
    <dbReference type="STRING" id="229533.I1RME1"/>
    <dbReference type="EnsemblFungi" id="CEF86401">
        <property type="protein sequence ID" value="CEF86401"/>
        <property type="gene ID" value="FGRRES_05130"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05130"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17173"/>
    <dbReference type="eggNOG" id="ENOG502QUH1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039854_1_0_1"/>
    <dbReference type="InParanoid" id="I1RME1"/>
    <dbReference type="OrthoDB" id="2127032at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000030">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000778">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF6">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="50"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF86401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="416" mass="46195" checksum="54114D418CBF3845" modified="2012-06-13" version="1">MDPLNVLMIGTGEYTTGFVGGGASGSDKKVGVVGLSLFDLRRREKVNKLGMVGVNGKKFPAIREHLNKNIQQVYNDLDTSFDSFPANDKVDPDAYKSAIDALSPGDAITIFTPDPTHFPIAKYAIERGIHVMITKPAVKALEEHQQLVELAQKKGVYVYVEHHKRYDPAYADARAKAQKLGDFNYFYSYMSQPKSQLETFKAWAGKESDISYYLNSHHIDINDSMVQERGYVPVSVNASSSKGVAVELGCDPCTEDTISLLVTWNKNGEPTKRAVGVYTASWTAPQKAGVHSNQYFHYLAANGEIRVDQAKRGYDVADDSVGQMMWYNPFYMKYAPDEDGNFAGQTGYGYISIEKFVDGCRAVNSGKLKPEDLDAKPLPTLKNTIATTAILEAGRRSIDENREVKIVIENGKWRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>I1RMG2</accession>
    <accession>A0A098DZ62</accession>
    <name>I1RMG2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">FG05152.1</name>
        <name evidence="16" type="ORF">FGRAMPH1_01T17227</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin 150 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323655.1">
        <property type="nucleotide sequence ID" value="XM_011325353.1"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RMG2"/>
    <dbReference type="EnsemblFungi" id="CEF87141">
        <property type="protein sequence ID" value="CEF87141"/>
        <property type="gene ID" value="FGRRES_05152"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05152"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17227"/>
    <dbReference type="eggNOG" id="KOG0971">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002523_1_1_1"/>
    <dbReference type="InParanoid" id="I1RMG2"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000743">
        <property type="term" value="P:nuclear migration involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022157">
        <property type="entry name" value="Dynactin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF6">
        <property type="entry name" value="DYNACTIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12455">
        <property type="entry name" value="Dynactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0243">Dynein</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="15">
        <location>
            <begin position="24"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="77"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1056"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="131"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CEF87141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1327" mass="148063" checksum="003D42AF83FBC8DA" modified="2012-06-13" version="1">MPDFKPGQTVQLNDGRKAIVRFAGATHFQVGEWIGVELEDKSGKNDGSVQGERYFDCPMGYGMFVKPVMATIIAQAPTPKPPARKPSRPSSYNPASGRASSAAGDAGLGRRKSLNAPSPSPVPRAARPTSLARSPTKSPTKQLSGVSSNSVSRTGTPSGSRAPSVGAKPRASVGGGRTPMGPPPPIARTTRQVSTSSTISRPGAAPPRTTNSRMSLGGPSRPGSAARRQSVDSQARRGSSDREEVISPPPNDNGDILSPQPRSPVQARTKALEKLTAGPASRQSTPPTSRKVSSTSTAGAARPAASTAASREIEDLKAKLKVLERKRAEDRDKLKQLETVQNERDKFESVIQKLQQKYQPQQQENAELKKLLREAEMRLESIEEFQQEHESILELATLDREMAEETAEVLRAELDALKEKAEEMELEVEVLKEENEEYSKGMTPEDRASTGWLQMERTNERLREALLRLRDLTQASEEELRDQISGLEDDMKEFNTMKEELSVCREKLEQSESAVEDLRQQLDNALGAEDMIEDLTERNMSMSEQIEELKAVIDDLESLKEINDELEINHVQNEKEMQEEMDFKDSVIAEQARRAGQQEEALEDMEYTLSRFRELVTSLQSDLDDMRASQAVTEGESEKLNDRSRAMMDLNMKLQISASKAQVKTIDLELRRLEAQEAEQHLEILKLFLPDTYKEDQDSVLSLLRFRRVAFKANLLNSFIRERLNGQPHPGHEDDVFAGCDASDKLVWVSNMCDRFVNDMTHCTIEQFSKYQNALHELEPVERALNVWIDGLRRDDLKEKTCADELHRTIALLSHLGEVHISNSLANYADDVHMKANIMQSHLDSAAVTFNTLRGLVQRVVPAEGDDEELAQHFSKKSEAVITNTRGAKVIAAKAVRALQDLRTRSLSLLPDTNEAFDECCEATQELADLARQIGLGLHNLFHADESRNEPFTYVEVQSSVHKTVLAVCTSSESDIFSTYLSKLRDVTTQISDLASLATDLDQVQEFDVATAPWRLRSHELKALKTIPVDAEEELRRIKEEHSEARRTIAQRDEHLSTAVLKIETLESRMRDAQANIDRIAKLQEELEASGQEIGGLKEDIEKQDRELKNLESERDKWKKIASDSRAYADGADAAGAKAGQERAVATAREMDALKKDIESLQSAVRYLREDNRRARTSEQHKYEWLAEPLKKPTSVTEQRRNMIATEGKDVLGELVKMASSASVYDFSTLPKDKLAWKPTRSTPQYHAAKQMEDYAAWGAWQESVLKKAHVLQGQAANAERRKKAPTTARLHIKLPGANGKMVPGSGREVQIVGSSEWEALQGRLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1RMJ4</accession>
    <name>I1RMJ4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG05184.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T17303</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323690.1">
        <property type="nucleotide sequence ID" value="XM_011325388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RMJ4"/>
    <dbReference type="STRING" id="229533.I1RMJ4"/>
    <dbReference type="EnsemblFungi" id="CEF86272">
        <property type="protein sequence ID" value="CEF86272"/>
        <property type="gene ID" value="FGRRES_05184"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05184"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17303"/>
    <dbReference type="eggNOG" id="KOG0256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_1_2_1"/>
    <dbReference type="InParanoid" id="I1RMJ4"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF63">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="39"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF86272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="426" mass="46992" checksum="CAEEFB4D1CE62F0E" modified="2012-06-13" version="1">MSLSKRANDAEKAIEGMDLWEVIPNLFDQETNPDGIVSLGVAENTLMHDVLRKHIHDNLALTNPAFTYGDGTTGTKQVKKSVSRFLTKHLKPFKAIEPAHITMTNGCSAAIEHLSWAVANPGDGILLGQPYYGTFVPDLTARFGAKLLPVAFGEVDPLGEAAVAEYEKVILEAQAQGTRVSGLVISHPHNPLGRCYSRSVLIAFMKLCQKYEMHFISDEIYALSVWTNTVDQHPLSVPFESALSIDTTDIIDTDRVHVLWGMSKDFGANGIRVGTIVSQANMSLHASIVAVGLYSSVSSISDHVTVNILEDDAFVESYIVENQKRLSAQYTRVVSWARKNQIEYAPGVNAAFFLWIDLGKYYMARHPGLETDDITDLIMSKLMAKKIFLASGKGFGSEKPGWFRIVFSHDDAYLDLGLERVINALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1RN86</accession>
    <accession>A0A098E318</accession>
    <name>I1RN86_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG05452.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T17945</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323990.1">
        <property type="nucleotide sequence ID" value="XM_011325688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RN86"/>
    <dbReference type="EnsemblFungi" id="CEF88506">
        <property type="protein sequence ID" value="CEF88506"/>
        <property type="gene ID" value="FGRRES_05452"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05452"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17945"/>
    <dbReference type="eggNOG" id="ENOG502S540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028752_0_0_1"/>
    <dbReference type="InParanoid" id="I1RN86"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008709">
        <property type="entry name" value="Neurochondrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109:SF7">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05536">
        <property type="entry name" value="Neurochondrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF88506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="626" mass="68985" checksum="7D67DEB2582D259F" modified="2012-06-13" version="1">MDKTTPTAASQPADINKILSLLKAKDDTQRFVGLALLKSVLDGSEQLRQDKQTVQSLWSSLSPKFLDRLLRTGSNPSTKNSKEMLDLIVSVLHIFAILLPDQATSDVKFINRIPLLVNAVLYSSEDTTKLILQLLHTLVSSQQGAQAFIKIEDFSSLTEIAPNHAQVLDILCFAWLNSMTGIEDHTALAKQVDDTLQSLVSSFTGTDGVTLLEFLGYFLRHANSIILPRQPKWLKNVVNHIRKLVTSRPTPEARAAYTNATASILQAFPTEARKLIFTDDRKEEKAFSYLLINLLLIDIRASAPSLLEQLNKPEYPKASTRLTSAFDVISIFIGYLVECLEDESLETFFMTPDNLLQLRTGVTETMSLTAEYLRDRWDASVAGAMGLHPDARTGATDTSAGKHHTLAWDSMKDNANDDMLILSAVRTLALWLREEENDTLRKEATGLTDMFMDLYKFSSQDKLDFRSAVLVALEGLIAVPQGCELLLANDGWTILTRDLGSILQHPRACREQDASRAIDIVRVLLPIVEQETSGVPESWMDLITSVAAWDIPDSGLSPLSQEALAAALQLCCAILVEANSGMRQRYQHSVAAIHGIAAQLAKQAGKDGPEAGTLEDVLDTLASLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I1RNF2</accession>
    <accession>A0A098E1K2</accession>
    <name>I1RNF2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG05528.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T18137</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324076.1">
        <property type="nucleotide sequence ID" value="XM_011325774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RNF2"/>
    <dbReference type="EnsemblFungi" id="CEF87986">
        <property type="protein sequence ID" value="CEF87986"/>
        <property type="gene ID" value="FGRRES_05528"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05528"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18137"/>
    <dbReference type="HOGENOM" id="CLU_2109271_0_0_1"/>
    <dbReference type="InParanoid" id="I1RNF2"/>
    <dbReference type="OrthoDB" id="10269010at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF87986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="115" mass="12436" checksum="D5BA9C075700F151" modified="2012-06-13" version="1">MYLKVTDKDKNPSVHTSSTGMTDWCETWVPSLGSPKQIGTPSHPLAVRADGGVISADGHICSEGPNLTNSGHVLHYIFCQLGPKIKSWHQQPDAVVFSLSGDNDPEIHYHAGQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1RNT2</accession>
    <name>I1RNT2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">FG05671.1</name>
        <name evidence="15" type="ORF">FGRAMPH1_01T18477</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the non-repetitive/WGA-negative nucleoporin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324242.1">
        <property type="nucleotide sequence ID" value="XM_011325940.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I1RNT2">
        <property type="interactions" value="1225"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RNT2"/>
    <dbReference type="EnsemblFungi" id="CEF86321">
        <property type="protein sequence ID" value="CEF86321"/>
        <property type="gene ID" value="FGRRES_05671"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05671"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18477"/>
    <dbReference type="eggNOG" id="KOG1900">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000429_0_1_1"/>
    <dbReference type="InParanoid" id="I1RNT2"/>
    <dbReference type="OrthoDB" id="338970at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051292">
        <property type="term" value="P:nuclear pore complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.440:FF:000001">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.450:FF:000002">
        <property type="entry name" value="Putative non-repetitive nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1880">
        <property type="entry name" value="Nucleoporin, helical C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.440">
        <property type="entry name" value="Nucleoporin, helical domain, central subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.450">
        <property type="entry name" value="Nucleoporin, helical domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042533">
        <property type="entry name" value="Nucleoporin_Nup155_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042537">
        <property type="entry name" value="Nucleoporin_Nup155_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042538">
        <property type="entry name" value="Nucleoporin_Nup155_C_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="14">
        <location>
            <begin position="141"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="13">
        <location>
            <begin position="679"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="38"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CEF86321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1402" mass="154884" checksum="CA1F78B888399DF5" modified="2012-06-13" version="1">MSFPQTTPVRPVPGAFLNTPAVTSRYQQGSDPVRRQLFPVSESGQSVSSLKSTAPTSSASRGVTVTGSSVVRPSSTDGLLVPTVLPPLRSENVPPVIKAAKAINTCLQADGRYPDLDSYCRQGASSDYDLESTDSAMAPFHKTQMYPIPNQVFDHYNAGELQTLMGLFAEINHAWVVIDNSLFLWDYTHPDPELIGFEDSPHTIHAVALVPPKPGIFVGSITHILVVATSQEIVLLGVSATDTPSGTKSVNLYQTKMNLPLRGTDVRVITGSSNGRIFFGGSNDIDINELYYQSEEKWFSNRCGKINHTNPGWSSVVTLQGSFWSQKSPEHLVDIVIDDSRNLVYTLSSRSTIRTYHMEAPDRLNKVIEKEKVHCLRDIAHMISQSRLLNDRVEIVAISPISKQEAAKLHLMALTNTGCRLFFSATSAASYLYGSSTNLAPQSMQVQFIKFPPGHRSPYAGSETTIDLDSNSLTWSRQGARFPPGYFLDFVRKESNPNEDSLFISGPETGRLKNTLPTSPLKYHESGIWIDIGSRAEAVGIITKPFAAASQPLGFGNELAVQFDDAPSEFAVLTNTGVHIIRRRRFVDIFASAIRGAVGDEGLELVCRRFINTYGRVETVTTALAVACGHGGDSRPGAARAIDQATEDRARSVFVDFGGQPTMAETDSASLTTESVNLSSRHDALALYLSRLIRQLWKSAVITPGVSPTGGITIGSTIPLTKLSTVQEALERLRRFLDSNRGLIQGLSGPSDLQHVSSRQEEIALQAEHQALHALQKLMESISEGISFVMMLFDERVADIYTRLDDTARQQLKDLTYEKLFSQTDGKDLAKLLVKAIVNRNIESGSNVETVADALRRRCGSFCSPDDVVTFKAQEQLKRASDQPLQTNQSRSLLHESLRLFEKVAGSLTFANLQTAVQQYIDLKYYAGAIQLCLVVAREKDRGNTALSWVNDGKPSSDPRANAFNDRKRCYDMIHDVLSHLDAASSSEPEMVDGRLTLIATKRLEAYKVVNESDDEVFHFDLYEWYIQQGWTDRILAIDSNHVVTFLQRLAGTNIEHADLLCRFYTNRSRFFDAAEVQAELANSDFPISIKDRIRLLSLAKANANVSTTGISRQQQQMLNHSVTELLEIAHIQDDLLERLRADDRIDPERAIEIEDALKGKIQGLSELFNDYADQAGYYDLCLLIYHVADYRNHMTISGTWSNLIQQTHDEVMSRLEMSEPGMPSPPLPYECVTSKIQNIAHRTSLDSFIFPIQDLLPELCRYAVAYQQDATIGADPTWPVQLFLTLGVSHDMIVRVLEGVFDSQDYGFSGSVRNRMIELIVYVVNDWVAEARRRGGAGKGGAIGPSVADLLKRCDAALPPPGHGNNAGGADLADVRRVLKGLKREVDGLSQRVPTGSLRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQ09</accession>
    <name>I1RQ09_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG06142.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T19589</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324772.1">
        <property type="nucleotide sequence ID" value="XM_011326470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQ09"/>
    <dbReference type="EnsemblFungi" id="CEF87328">
        <property type="protein sequence ID" value="CEF87328"/>
        <property type="gene ID" value="FGRRES_06142"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06142"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19589"/>
    <dbReference type="eggNOG" id="KOG2816">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013756_0_0_1"/>
    <dbReference type="InParanoid" id="I1RQ09"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="63"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="518"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF87328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="539" mass="60085" checksum="DFC5E28268911BCB" modified="2012-06-13" version="1">MPSKYQPVASDDVELESHLDAPLLDLDPLEDDPANDNDTFHPRSEPVPSYRASRWGVRSPKRIVILVSVIKFAVVFSGMLLILPTARLIEDMFCHIHYNDTSTDIIDEMKCKVDEVQSQLGYLFGWNGLVTSLIGLIVAFPYGTMSDKIGRKPIVMFSWIGIAICFLFAPFSIKAFHGSLRDRPYLLVLGGFFQVFGGGVPVLMSTLYSIAADVSTEENKSKHFLWSAFGAAAGGISGPAVAGILMNKYGPWLPIYLVLFTVPIIMGVLVLLPETLTVNVKNQQAQSGKRAPSTLKEHMSHGVKDLQQSLNMLKNVSVTMILVTFFIQNARYAAYTTTMSQYISKHFKWTMADVSLVLSPMGILDLIILAGLPKVGDRLMSPRFRMTAFGKDLFLTRISTVMLVLGAFWQGLSPNVVMFFFGLFIETFGAATGPLARATVTHYVQPEYTARLYALIGMIEVVGSFIAGPVLAWCFDQGLKRKGIWIGLPWFYVSFLCFIALVALYFVKPPKKRSREEEVIDNEGYETDDYMPDDPLRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1RRB5</accession>
    <name>I1RRB5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG06633.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T22787</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_011326256.1">
        <property type="nucleotide sequence ID" value="XM_011327954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RRB5"/>
    <dbReference type="FunCoup" id="I1RRB5">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RRB5"/>
    <dbReference type="EnsemblFungi" id="CEF83129">
        <property type="protein sequence ID" value="CEF83129"/>
        <property type="gene ID" value="FGRRES_06633"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06633"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22787"/>
    <dbReference type="eggNOG" id="ENOG502RFKK">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016658_1_0_1"/>
    <dbReference type="InParanoid" id="I1RRB5"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cAMP catabolic process"/>
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    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
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    </dbReference>
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        <property type="entry name" value="class_II_PDE_MBL-fold"/>
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        <property type="entry name" value="Pdiesterase2"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PDIESTERASE2"/>
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        <location>
            <begin position="207"/>
            <end position="238"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="403"/>
        </location>
    </feature>
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        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF83129.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="502" mass="54274" checksum="C66000B27DD3A843" modified="2012-06-13" version="1">MGGDTKPALQVIVLGSGGGPQESNTTAFLVRSVGAKWHRGSIIAVDAGVHLSSITRIMEESIPSPPPTPPFTLTTGPFAGLELPYSSPAANAAHITRTLVDTYLITHPHLDHISGFVVNTAGFPGTRPKKLAALPSTIKAFKNHIFNNVIWPNLSDENNGAGLVTYMRLVEGGSPSLGDGETRGYIEVADGLLVKIWSVSHGHCLEKHSHRGSTSSTSTRFSSHDASMPHGPPARSNSYYPGSLHRSSVLLSQGSFGSISLPPTPDQERMCVYDSSAYFIQDPITNREVLIFGDVEPDSISLSPRNLQIWQEAAPKIASGNLRAIFIECSYDDSQSNDRLFGHLKPVFVMEELRALATEVNTVRSMRSADTKKRKRMGSTVDEGPRRNPSLANFTSEDPVSPKTLKASTPDFVYPGPETPPTPHLATPTAELTLNPSDSITSVPATRKPLEGLQIVIIHVKDRLDDGPDVGNTILEQLNDHESEAQFGCEFIISKPGKSFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RRL5</accession>
    <name>I1RRL5_GIBZE</name>
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        <submittedName>
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        <name evidence="5" type="primary">FG06744.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T23069</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326389.1">
        <property type="nucleotide sequence ID" value="XM_011328087.1"/>
    </dbReference>
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    <dbReference type="ESTHER" id="gibze-q4i7r4">
        <property type="family name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF85275">
        <property type="protein sequence ID" value="CEF85275"/>
        <property type="gene ID" value="FGRRES_06744"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06744"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23069"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_7_5_1"/>
    <dbReference type="InParanoid" id="I1RRL5"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="39"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF85275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="344" mass="38391" checksum="E7C8E201385F7EFE" modified="2012-06-13" version="1">MAPDKLVPNDPRVKHETAQIRGKTYKYIVGEPEGTPLETMVLVHGFPDLGFGWRYQVPYFMSLGFRVIVPDMVGYAGTDAPESLEEYTYKSLSADINELARKFVGKDGQIVLGGHDWGGMIVWKVSTWYPELIKCVFSVCTPYMQPRETFLPLEAIIASGHLLNFSYQLQFKGPDVESHIQGKEKVRQFLNGMYGGRTPNGELGFSAKEGVLFDNLAELGPSPLISKEDLDYYAEQYCLHPAPEMRGPLNYYRTQELNYRDDVEIAKKGGNKFKMPAMMITASNDSALPPAMSQGMDSSFDNLSRAEVQASHWALWQASDAVNQHLTKWLDGVLGGALEAKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1RSF3</accession>
    <name>I1RSF3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG07071.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T23889</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326771.1">
        <property type="nucleotide sequence ID" value="XM_011328469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RSF3"/>
    <dbReference type="EnsemblFungi" id="CEF84100">
        <property type="protein sequence ID" value="CEF84100"/>
        <property type="gene ID" value="FGRRES_07071"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07071"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23889"/>
    <dbReference type="eggNOG" id="ENOG502SAKR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022094_0_0_1"/>
    <dbReference type="InParanoid" id="I1RSF3"/>
    <dbReference type="OrthoDB" id="5401332at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037504">
        <property type="entry name" value="PSI_induc_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018:SF1">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF84100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="441" mass="48133" checksum="1120321796016D72" modified="2012-06-13" version="1">MPSIDEAMARSLRGSAWEIVKDKFVRTIVSDLTRRDMLADAAQTTDSISKTSDDFATAISSWDNCMSVVWCKWPVIGIMILGGLIIFSILWCIIRCCCCGLSCCCSCCQCLKCCGNCCGACDPPGSHTKHLDDPYPPQPQHHGYRTEPPMNPSVPQYGVSQPIRNEPPQYAEYEISKKDDDALPEMPSSEGKKVQVYTEAVELDTLSKPPPSQHSMAGTPYSQPQGNSSGYLGSSQPTDPYSPLDQQGYGYQPPPPNQVYAPAAIAPMPHERRSPALGQNAYGNQGYGHDQGFEQAPGFGQMQGHGQNQSYGQGASPQDYAANYGGYCASPSPRPAQRLSMHQDEFGSYGNMPPRRSPAIPDDYGYGSPARQSPGSQNDFGYAQPLRHSPAPMNDYRTPPPGPDANYGPRPVPQRQQLLESQSPGSYEPQQPYPGFKPYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1RU85</accession>
    <accession>A0A098DTG2</accession>
    <name>I1RU85_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG07769.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T25607</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327584.1">
        <property type="nucleotide sequence ID" value="XM_011329282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RU85"/>
    <dbReference type="EnsemblFungi" id="CEF85161">
        <property type="protein sequence ID" value="CEF85161"/>
        <property type="gene ID" value="FGRRES_07769"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07769"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25607"/>
    <dbReference type="eggNOG" id="ENOG502RJ26">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109450_0_0_1"/>
    <dbReference type="InParanoid" id="I1RU85"/>
    <dbReference type="OrthoDB" id="5006522at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF85161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="236" mass="25332" checksum="163923DD53814360" modified="2012-06-13" version="1">MSSNTTTSLLLPEYRGHFVAEVVGADPTATTFVLDCDWDKYPWDGDDDCHVTKRTFVVGPWVDKTPTPGAPTKGIYKEIYVAKALGEEVDDFSFSAECQMSKTWAETCTTVNIGGNARYGVTATFPRATGMVLDEFYDVYGYGAFDWVPVTVTAGQEYLLAAKTTVAASTEASTTSDAKPTKETTTGDESEKLVKKDVVTLEGKASPTKATASEACAKRVLSLWGLVGLVAAIGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RUK0</accession>
    <name>I1RUK0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG07896.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T25923</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327728.1">
        <property type="nucleotide sequence ID" value="XM_011329426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RUK0"/>
    <dbReference type="FunCoup" id="I1RUK0">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RUK0"/>
    <dbReference type="EnsemblFungi" id="CEF83423">
        <property type="protein sequence ID" value="CEF83423"/>
        <property type="gene ID" value="FGRRES_07896"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07896"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25923"/>
    <dbReference type="eggNOG" id="ENOG502SHVS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026450_5_0_1"/>
    <dbReference type="InParanoid" id="I1RUK0"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054710">
        <property type="entry name" value="Tri101-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF64">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22664">
        <property type="entry name" value="TRI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trichothecene 3-O-acetyltransferase-like N-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF83423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="451" mass="49399" checksum="D6F0C65F6C0F4DCB" modified="2012-06-13" version="1">MAFKIQLDTLGQLPGLLSIYTQISLLYPVSDSSQYPTIVSTFEQGLKRFSEAVPWVAGQVKAEGISEGNTGTSFIVPFEDVPRVVVKDLRDDPSAPTIEGMRKAGYPMAMFDENIIAPRKTLPIGPGTGPDDPKPVILLQLNFIKGGLILTVNGQHGAMDMVGQDAVIRLLSKACRNDPFTEEEMTAMNLDRKTIVPYLENYTIGPEVDHQIVKADVAGGDAVLTPVSASWAFFTFSPKAMSELKDAATKTLDASTKFVSTDDALSAFIWKSASRVRLERIDGSAPTEFCRAVDARPAMGVSNNYPGLLQNMTYHNSTIGEIANESLGATASRLRSELDPASMRQRTRGLATYLHNNPDKSNVSLTADADPSTSVMLSSWAKVGLWDYDFGLGLGKPETVRRPIFEPVESLMYFMPKKPDGEFCAALSLRDEDMDRLKADKEWTKYAQYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RW26</accession>
    <name>I1RW26_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="6">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG08479.1</name>
        <name evidence="6" type="synonym">CTU1</name>
        <name evidence="6" type="synonym">NCS6</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T10067</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="6"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320285.1">
        <property type="nucleotide sequence ID" value="XM_011321983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RW26"/>
    <dbReference type="FunCoup" id="I1RW26">
        <property type="interactions" value="468"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RW26"/>
    <dbReference type="EnsemblFungi" id="CEF76836">
        <property type="protein sequence ID" value="CEF76836"/>
        <property type="gene ID" value="FGRRES_08479"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08479"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10067"/>
    <dbReference type="eggNOG" id="KOG2840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026481_1_3_1"/>
    <dbReference type="InParanoid" id="I1RW26"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="8">
        <location>
            <begin position="54"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="9">
        <location>
            <begin position="360"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004976-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF76836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="392" mass="43052" checksum="70824F732FF9DF2E" modified="2012-06-13" version="1">MAPAPCFRCKNNRAVVKRPKNHHKLCRDCFIQVFEDEVHHTITSSKLFFRGERVAIGASGGKDSTVLASVMKTLNERHDYGLDLVLLSVDEGIKGYRDDSLETVKRNAVQYDMPLEIVGYDELYGWTMDQVVETIGKKGNCTYCGVFRRQALDRGAKKLAIQHVITGHNADDVAETVLMNLLRGDMPRLSRSTSIVTGNSSSEVMRSKPLKYAYEKEIVLYAHHKKLDYFSTECIYSPEAFRGTARGLIKNLEKVRPSAILDIVRSGEDMARLTPDKGQGACGGCDEGEGIGGCGSANGRTSGNEMAQVEASLKKQHKSAALETEITTNGTPKDDAVPLPVRTKKAKQKEAPPAPKQSLGKCIKCGYMSSQTMCQACTLLEGLNKNRAEIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>I1RW83</accession>
    <name>I1RW83_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG08544.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T10221</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320211.1">
        <property type="nucleotide sequence ID" value="XM_011321909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RW83"/>
    <dbReference type="FunCoup" id="I1RW83">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RW83"/>
    <dbReference type="EnsemblFungi" id="CEF76914">
        <property type="protein sequence ID" value="CEF76914"/>
        <property type="gene ID" value="FGRRES_08544"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08544"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10221"/>
    <dbReference type="eggNOG" id="KOG1868">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005922_0_0_1"/>
    <dbReference type="InParanoid" id="I1RW83"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="383"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="680"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF76914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1057" mass="118623" checksum="17B3709B299F74BC" modified="2012-06-13" version="1">MASLGHSRASSVATAGSHSLGSPGAFNHGSIPTSHRGGDSPSKASLPHIDDVIAPPQDLDPNMSARKLLETAETALRQAEMSRDFRRPAIALKEYIRASIIAIQILTKHPDYHDLKANHADFRRAHMNLLNKISDQDPIYAKVKQDIIADNKRSGVQPRIVRSNLSQGGSRPQTPSGLTADGTMSPSKPRFNGAVTNGSPARSKPMIQPKPQSLHGNAIRTGVQKETRPVNQDLAARFANLRGPQASPGQDPRIKTHHIPLPKPMGPREMPPPRPPKVGIDTSVPTLPKMPDAIYSPARGSISGEVTRPPSSTPRSLYRTASTASGPGTPNASSQSQPDYFAPTQSYSNNSIPPAPPSNLTSPIKIPDGHTISPEELYQAMKAKGRILVIDIRMRDDFNDGHILSSSTICIEPSILLRDNPSADDISESLILSPNQEQSLFEQRNLYDLVVFYDQDSKDFPRQPRNQDDMAIISLHHALVHFNYMKELKNTPKMLEGGLDAWIDLMGQASLGSTTSAVSRSGQLDRNRNRQSGIERVRSKYIVKPLKPDEVKVWQETLKHDDDMQTASSPNFTRTTEDFLRRFPPVSLEQESMVSPEEKPQNRAVYGLSHKVDLYTDLPSPPTRPAPALPRRSYSGLTEGRDENELYGNNNTVVPARPSRVPTMKSLEHQLTGDSNKFYTGLNNPHNWCYANSTLQSLLASPDFGKMLANSEWVTKYKAPRKQDEKIDHPQLMIRIISNLFHWMNSGKFQIMKAQTLMDYSRHLCEQSRSIEQFGGSQQQDAQEFMSFILTHLHDETNTRRDRQGNIPQPDTSRQTLLKAAIQFWNNHLEYNQSIVDRFWRGLELSTVECLECSTRTYMYTTFDLITVTVGMGRGMTLEQAFDEYASSSPIEDFACARCCRPTHAQQSLSFARFPTLLCVAFRRFNYQPATRDTRKSTAPITWDFNDTDFTRYFLPRGARESSSGTDPMDPSFTGPFRYEAYAVIIHTGSQINNGHYLAYVRDYTSHDPYAWYCCNDTRVTKVRIGSGDRDDVQEEVFKSGRDKVPYLVFFRRKGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RWD0</accession>
    <accession>A0A098DEW8</accession>
    <name>I1RWD0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG08594.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T10337</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320156.1">
        <property type="nucleotide sequence ID" value="XM_011321854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RWD0"/>
    <dbReference type="STRING" id="229533.I1RWD0"/>
    <dbReference type="EnsemblFungi" id="CEF76972">
        <property type="protein sequence ID" value="CEF76972"/>
        <property type="gene ID" value="FGRRES_08594"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08594"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10337"/>
    <dbReference type="eggNOG" id="ENOG502SAE9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016938_1_0_1"/>
    <dbReference type="InParanoid" id="I1RWD0"/>
    <dbReference type="OrthoDB" id="5350396at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="633" mass="71049" checksum="F3D33AF5164AB7F1" modified="2012-06-13" version="1">MSQNSKNGNIMSFFKPKTKSPTPKATKSSTPDPPSSPMLPSSPLEQKAATPVKKNLSPTPKRVIQASDDEDDFGASSDDSLEDISTMIGRGRPAKATQSPARNLFATPKAKRTAVEFRTSPLAIISKHKYDLKALAKDARQDNAITASSMRAKAFSDLEDQVDVQMTTDKASLDAMEGIVKNNTGQDAQKVMRAVKRSETGQSELRYCFFSQDYTLPPPNPPPKKFNKGHWKLLTKGDQKTREQHLASGVPLTLLHLQGGLPEELFDWILNDICAQKSSLVRQEYCNLLSNCTDLIEHCITPQRLEELLYRFGASSELGQRDSELDVSKPGVEPYEGRDWSPLSSFLSLLAAIPPYMSEDSVVYASQALLRMSMDRFLIYDIGLLTTYEITISILLEAIPQPRWDTFCFETCTLLHTLIKAQCIRTNALACLPLSKARAHEMRRRLAVVFLFDDPALGRCHPDDTVTIRGIIKRLDRSDFFVGPKTDFAELQANIILLNIAVDDGSFAPSDDPEHEKQFNKDIDELAVRLREIWRKINDSGMKLARTEAKSVIEWVEQRLAHSVRTRRKAKKSIFDLPGQNQDLCLPEQQNYMKNFLRKAPETTSVQAPKQLTSDTEGLKETRNPETIVAKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1RWH6</accession>
    <accession>A0A098DDI7</accession>
    <name>I1RWH6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG08646.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T10473</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320096.1">
        <property type="nucleotide sequence ID" value="XM_011321794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RWH6"/>
    <dbReference type="STRING" id="229533.I1RWH6"/>
    <dbReference type="EnsemblFungi" id="CEF77039">
        <property type="protein sequence ID" value="CEF77039"/>
        <property type="gene ID" value="FGRRES_08646"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08646"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10473"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021219_0_0_1"/>
    <dbReference type="InParanoid" id="I1RWH6"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="PHI-base" id="PHI:1404"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="Zinc_finger_trans_reg"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="530"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="558"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="67"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <end position="302"/>
        </location>
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            <end position="362"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="385"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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            <begin position="81"/>
            <end position="109"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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            <begin position="148"/>
            <end position="161"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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        </location>
    </feature>
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            <end position="448"/>
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            <begin position="515"/>
            <end position="525"/>
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    </feature>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="640" mass="69548" checksum="7DE7BA8EF15A0B39" modified="2012-06-13" version="1">MDILRHLSVRKSHVTGHLETRGVVSKRQLSDGGIAGVVVGVIVGIALVALCSYPFIIRRIRRRRQVHSHGPGDANDPETGETPTAGSSPTVDHQRRLSSQDSFKPSGENTRGGVDGSVKDLDWAPHDALIQPNGQPQALTQPDIGHRLNTNLPSQDFNNAQPGFDNSIPRSAPFSVDGTYEEYMPQSIGDAHDGTLNGTSADYYSPAVPSEAFGMFPTEEPRPEPQRSWSRGSSLKHNLKQLFSRKSTRDQSFSSPTSLSLTEGPETTRAAPHTTQDVPLQRITTAGDPTESPTDITAPAADSFPVPHTAQALGSPIALPSTLPKDAVSSSPEYSPTTFNFNASQSPPTHPAPGTVNPMDMMPASTESELWHRTNYELYVAQSSPQQLHPSMEPGRNDGPVDSPSPLTLAPNTPQPQPQLLPVIQSPTPTQSETTLKKEEPDESHDVSMSDIPSNHHLSPLPDSSVRHPSYPSDASTPQPGPASTNPSSLNTPATQLDTPSPHSGTSSDHRPSVSPGNGASNLSPKNGVYACDEPGCHQVFDQAHKLKHHQRYHTKDHKCPYPNCGKGFGTKTHLQRHINDRHERKKKFHCAVPGCDYSRQGGKGFPRKDNWKRHMTKIHNMDQRYLPEPVEVDQDMGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RX43</accession>
    <name>I1RX43_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG08892.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T11101</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MATALPHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319815.1">
        <property type="nucleotide sequence ID" value="XM_011321513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RX43"/>
    <dbReference type="STRING" id="229533.I1RX43"/>
    <dbReference type="EnsemblFungi" id="CEF77353">
        <property type="protein sequence ID" value="CEF77353"/>
        <property type="gene ID" value="FGRRES_08892"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08892"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11101"/>
    <dbReference type="eggNOG" id="ENOG502S4ZK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_809024_0_0_1"/>
    <dbReference type="InParanoid" id="I1RX43"/>
    <dbReference type="OrthoDB" id="5398665at2759"/>
    <dbReference type="PHI-base" id="PHI:1495"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045895">
        <property type="term" value="P:positive regulation of mating-type specific transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006856">
        <property type="entry name" value="MATalpha_HMGbox"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04769">
        <property type="entry name" value="MATalpha_HMGbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51325">
        <property type="entry name" value="ALPHA_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Alpha box" evidence="6">
        <location>
            <begin position="55"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF77353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="345" mass="38810" checksum="EA2A8A7D4EEDDE4C" modified="2012-06-13" version="1">MSDYKDQVLEALTNCSQERLNAAMENPSMMRELLEICGTELAACIGPSIGDPVQRAKRPLNGFMAFRTYYLKLFPDTQQKDASGFLTQLWATDPNRNKWALIAKVYSFTRDHVGKAKCNLNPFLSVACPMMKIVEPSEYFGLFGWQVSHDSFGNMVLVQDLAVMANTMPPLENLEHPTTEIDLLTDILVAGYFSEYSQHLQVLMWTSQNGIMAPAGTFVNDAIGEQLYEPVPTTSEKTDFIESVCNNACEAAQALFGPDYDAQFFQSRFVHSWEVDDLTSFQGVQISIADEPLPTNTLYDFNQLPENVPQVSELTIDTSIDADIMEITSAWSVDKITFDRLNRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RXT9</accession>
    <name>I1RXT9_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear movement protein nudC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T27769</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for nuclear movement. May interact between microtubules and nuclei and/or may be involved in the generation of force used to move nuclei during interphase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328617.1">
        <property type="nucleotide sequence ID" value="XM_011330315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RXT9"/>
    <dbReference type="STRING" id="229533.I1RXT9"/>
    <dbReference type="KEGG" id="fgr:FGSG_09165"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27769"/>
    <dbReference type="eggNOG" id="KOG2265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047332_2_0_1"/>
    <dbReference type="InParanoid" id="I1RXT9"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000001">
        <property type="entry name" value="Nuclear migration protein nudC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="6">
        <location>
            <begin position="22"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SCB65502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="188" mass="21028" checksum="36B75ED52C12FF5E" modified="2012-06-13" version="1">MTDKEPTPAETAAATAKEAEEQAALPYKWTQTISELNATFDVPGNLKSRDLVITIKKMSLQAGIKGQDPIIQGDLPHAVHVDDSTWTLSTNSDGTKTVEIHLDKVNKMEWWPHVVTSAPKIDVTKIQPDNSKLSDLDGETRGMVEKMMFDQQQKEKGLPSSDEQKKADILKKFQEQHPEMDFSKAKIQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>I1RY81</accession>
    <name>ER10B_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferase ERG10, cytosolic</fullName>
            <ecNumber evidence="8">2.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Acetoacetyl-CoA thiolase ERG10</fullName>
            <shortName evidence="7">ACAT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Cytosolic thiolase ERG10</fullName>
            <shortName evidence="7">CT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ergosterol biosynthesis protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ERG10</name>
        <name type="ORF">FG09321</name>
        <name type="ORF">FGRAMPH1_01T27377</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="1228" last="1228">
            <title>A phosphorylated transcription factor regulates sterol biosynthesis in Fusarium graminearum.</title>
            <authorList>
                <person name="Liu Z."/>
                <person name="Jian Y."/>
                <person name="Chen Y."/>
                <person name="Kistler H.C."/>
                <person name="He P."/>
                <person name="Ma Z."/>
                <person name="Yin Y."/>
            </authorList>
            <dbReference type="PubMed" id="30874562"/>
            <dbReference type="DOI" id="10.1038/s41467-019-09145-6"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 8">Acetyl-CoA acetyltransferase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (By similarity). ERG10B catalyzes the formation of acetoacetyl-CoA from acetyl-CoA (By similarity). The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase ERG10B that catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthases ERG13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases HMG1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>2 acetyl-CoA = acetoacetyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21036"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">Expression is regulated by the Zn(2)-C6 fungal-type transcription factor FgSR which binds directly to the promoter.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="8"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328435.1">
        <property type="nucleotide sequence ID" value="XM_011330133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RY81"/>
    <dbReference type="SMR" id="I1RY81"/>
    <dbReference type="FunCoup" id="I1RY81">
        <property type="interactions" value="613"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RY81"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T27377">
        <property type="protein sequence ID" value="FGRAMPH1_01T27377-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G27377"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09321"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27377"/>
    <dbReference type="eggNOG" id="KOG1390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_1_1"/>
    <dbReference type="InParanoid" id="I1RY81"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF165">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0752">Steroid biosynthesis</keyword>
    <keyword id="KW-0753">Steroid metabolism</keyword>
    <keyword id="KW-0756">Sterol biosynthesis</keyword>
    <keyword id="KW-1207">Sterol metabolism</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000454670" description="Acetyl-CoA acetyltransferase ERG10, cytosolic">
        <location>
            <begin position="1"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="1">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P24752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P41338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q4WCL5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="30874562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="30874562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="30874562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84991"/>
        </source>
    </evidence>
    <sequence length="396" mass="41189" checksum="D0FB61FCD13CF7C7" modified="2012-06-13" version="1">MANLPPVYIVSTARTPIGSFLGSLSSQTAVQLGSVAIKGAVERAGIKPEDVDEVFFGNVLSAGVGQGPARQCALGAGLPQTVIATTVNKVCASSLKAIILGAQNIMLGTSDIVVAGGTESMSNTPHYLPNLRNGAKYGDQTLVDGVLKDGLTDSFKKDHMGISAELCVDDHDLTREAQDEYAINSYKKAQAATEAGLFTEIVPVEIPGGRGKPAIKVERDDEVKNLNVDKLKAMRPAFKPDGTVTAPNAAPINDGAAAVVLVSEAKLKELNLKPVAKILGWGDAEREPERFTIAPALAIPKAIKHAGLTAEQVEYYEINEAFSAVALANMKILGLNPDQVNVYGGSVAIGHPLGCSGARIVTTLTSVLKERKAKIGAVGICNGGGGASAMVIENLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1RYD9</accession>
    <name>I1RYD9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG09386.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T27215</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328359.1">
        <property type="nucleotide sequence ID" value="XM_011330057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RYD9"/>
    <dbReference type="STRING" id="229533.I1RYD9"/>
    <dbReference type="EnsemblFungi" id="CEF83636">
        <property type="protein sequence ID" value="CEF83636"/>
        <property type="gene ID" value="FGRRES_09386"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09386"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27215"/>
    <dbReference type="eggNOG" id="KOG3066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067225_2_1_1"/>
    <dbReference type="InParanoid" id="I1RYD9"/>
    <dbReference type="OrthoDB" id="31005at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF83636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="260" mass="29483" checksum="CE5CB3B79F189A3B" modified="2012-06-13" version="1">MSSGVKRDRDGNARAKNAGPPKQSGPKGRFHDMFEGFRNELDEHHDRRERIVKASRDVTAMSKKIIFTLQRVKHLNKDFPPHIQQDIDTRLEEIAKILSAIAPDLQNVNRYRYTSPLRCLEEFVEALSFAHYLRHQTIITPTQAQAAMPADMSLTPHDYMYGIFDLFGELMRFATVTTAQTGELAGNGERNIMGDIQELGCEFEILPDVPTKDWRGKMGAMRQSVKKVEKLGYGLVVRGSERPKGWVPDMKDDAPEPTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1RYM5</accession>
    <name>I1RYM5_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lactoylglutathione lyase</fullName>
            <ecNumber evidence="3">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Aldoketomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ketone-aldehyde mutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Methylglyoxalase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">S-D-lactoylglutathione methylglyoxal lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FGRAMPH1_01T26981</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328241.1">
        <property type="nucleotide sequence ID" value="XM_011329939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RYM5"/>
    <dbReference type="SMR" id="I1RYM5"/>
    <dbReference type="FunCoup" id="I1RYM5">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RYM5"/>
    <dbReference type="KEGG" id="fgr:FGSG_09482"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26981"/>
    <dbReference type="eggNOG" id="KOG2944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_0_1_1"/>
    <dbReference type="InParanoid" id="I1RYM5"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="13">
        <location>
            <begin position="48"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="13">
        <location>
            <begin position="207"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SCB65430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="360" mass="41461" checksum="391189AC825F08B4" modified="2012-06-13" version="1">MSFARAVQRIKSIQNFLTRPTVPHISAAAAGQSRLINMASTTETNNYKFNHSMIRVKDPKASTKFYEFLGMSLVKKLEFPDNKFDLYFFGYDSPNALSHNKSTFDRQGLIELTHNYGTENDPEYKVNNGNQDPHRGFGHTCIAVDNIQAACQRIEDAGYKFQKKLTDGRMRNIAFVLDPDGYWVEVVARNDYKETENVKETDVSTYTMNHTMLRVKDAEKSLKYYQEVLGMSRLRTLENPEAGFNLYFLGYPGDQPFPEGQDDKAITHREGLLELTWNYGTEKEENFKYHDGNSEPQGFGHICVSVDNLEAACKRFEDMDVSWKKRLTDGRMKNVAFLLDPDGYWIEIVQNEKFSGKENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RYQ9</accession>
    <name>I1RYQ9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG09517.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T26897</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328201.1">
        <property type="nucleotide sequence ID" value="XM_011329899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RYQ9"/>
    <dbReference type="EnsemblFungi" id="CEF84858">
        <property type="protein sequence ID" value="CEF84858"/>
        <property type="gene ID" value="FGRRES_09517"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09517"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26897"/>
    <dbReference type="eggNOG" id="ENOG502S7GF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038380_1_0_1"/>
    <dbReference type="InParanoid" id="I1RYQ9"/>
    <dbReference type="OrthoDB" id="5398515at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF84858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="420" mass="47228" checksum="3DA7B003B9361199" modified="2012-06-13" version="1">MADAHGSTTPPPPSRIRTPPTPRLGYQDHWEPFSPRKSARISSKRTRTPSPGASDRQPRSPQTAKKPTKHLSAGIASPMTQKKRVPANDFVRRATENMHAETSRDGASRRTHERSSSSVIATGGMLPTPSKTPQKPPTEKKAAHIKAVARNLFSSDADEVTLTPKKRSAKKYSGFSLESFVVEEIEEPIEIFTDTRDRVPVRDEREDNPFLSSENPFFSEAPRAGPSKRHDKRKVKVPGEGVKTVDELADRKDGMVYTFRGKRFFRKFTEHEVEDLDEIQAAEEDPEAHVRRPLTRASIKPRLLFQDVKTEEQIEEEEAVTDVEENVEELACPATPTVSKKERESTPEAPKFAPASPPSTRRVTRSANKLTDESAPVIKRPSKRSPFDSWRRTKESAPKSPSRKRSGESIDTRETKRTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>I1S2B6</accession>
    <name>I1S2B6_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Vesicular-fusion protein SEC18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">FG10903.1</name>
        <name evidence="17" type="ORF">FGRAMPH1_01T20763</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF85817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325477.1">
        <property type="nucleotide sequence ID" value="XM_011327175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S2B6"/>
    <dbReference type="FunCoup" id="I1S2B6">
        <property type="interactions" value="830"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1S2B6"/>
    <dbReference type="EnsemblFungi" id="CEF85817">
        <property type="protein sequence ID" value="CEF85817"/>
        <property type="gene ID" value="FGRRES_10903"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10903"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20763"/>
    <dbReference type="eggNOG" id="KOG0741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008037_2_0_1"/>
    <dbReference type="InParanoid" id="I1S2B6"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000026">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000012">
        <property type="entry name" value="Vesicle-fusing ATPase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000187">
        <property type="entry name" value="Vesicular-fusion ATPase SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="16">
        <location>
            <begin position="70"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="15">
        <location>
            <begin position="188"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="329"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="611"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00056429"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00068637"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CEF85817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="822" mass="89640" checksum="DFC361417EAE7D7E" modified="2012-06-13" version="1">MSRTPFSGFMGGSRGQQPPPPQQQQGYGGPRYNDPRQQQQPPQNYQSYPGGSGGGGYAEKPSRSGGRQVSLRVEKVTDKSLQSRLIYGNLCAVSPDDFPPNRDGSDLYILLQAGQPMGEYVVTAKPVPGFPQGCISLSDPQRSWAGITMRDVFQGEIYDPFAAGGKAYLGSVNLEIGFASPNKKTDVPYDEDELSKMFIETYQNQVLAPGQRILMDHRNIPLLIVVKTVSLTDLAMTSDDSSKKAQREPHARGILTTQSQVVFHRDAKGDFNLKPSMHKPNSNAILAPDFKFEDMGIGGLDDEFATIFRRAFASRIFPPGLIAKMGITHVKGLLLYGPPGTGKTLIARQIGKMLNANPPKVINGPEVLNKYVGQSEENIRKLFADAEKEYKEKGDESSLHIIIFDELDAVCKQRGSGSGGGTGVGDSVVNQLLAKLDGVDQLNNILLIGMTNRKDMIDDALLRPGRLEVHLEISLPDEAGRLDILKIHTAKMASNGLLDSSIDLDELAGMTKNFSGAEISGLVKAAASCAFSRHTEVGQLAAVKQDVASMNVKREDFMVALTEVRPAYGVSEAELMEAIRLGIYPYAPHIDMNIQQMMRVVGMVKEDPNKFSTSVLFHGPQGSGKTALAAHIAMQSGFPFVKMVTPSDLVGYRDDFAKKDYVHKAFTDAYKSPASILILDDFERLIGWNPIGPRFSNTMLEALTTLIVSRPPKGHRLLVFVTTSKASVLKMLEIDNDFAKKVAVPGVSNLRELAAVLQESPEFEHDPNAAVNEIGRQTGSDSVGVGIKTILDCIFESKRDPNGQVIEAFVELVVGKIQELRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1S2K5</accession>
    <accession>A0A098E2Q8</accession>
    <name>I1S2K5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG11001.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T20981</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325369.1">
        <property type="nucleotide sequence ID" value="XM_011327067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S2K5"/>
    <dbReference type="STRING" id="229533.I1S2K5"/>
    <dbReference type="EnsemblFungi" id="CEF87894">
        <property type="protein sequence ID" value="CEF87894"/>
        <property type="gene ID" value="FGRRES_11001"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11001"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20981"/>
    <dbReference type="eggNOG" id="KOG0707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1219748_0_0_1"/>
    <dbReference type="InParanoid" id="I1S2K5"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="5">
        <location>
            <begin position="50"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF87894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="199" mass="22140" checksum="B03A8B814A913F0A" modified="2012-06-13" version="1">MTTSTTHQDMDKDMDINDSSTSSLSLDASLEAFPNTRPIVVSGPSRASLGEVEGTTYNFVSHSTFAQMIETGSFIEYTVVRGDYYGTSRDAVTALQREGSIALLEVNDQGSRAIAKAQGNNARFVYITPPTFHESEYHLGARRMRCRPIRQKLIYNPKSDQTCPVLGIRISNADLDQAQKELEEFVFFTLLDEPAPTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1S348</accession>
    <accession>A0A098E1I8</accession>
    <name>I1S348_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG11213.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T21497</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325126.1">
        <property type="nucleotide sequence ID" value="XM_011326824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S348"/>
    <dbReference type="EnsemblFungi" id="CEF87960">
        <property type="protein sequence ID" value="CEF87960"/>
        <property type="gene ID" value="FGRRES_11213"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11213"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21497"/>
    <dbReference type="eggNOG" id="ENOG502SQJN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_534363_0_0_1"/>
    <dbReference type="InParanoid" id="I1S348"/>
    <dbReference type="OrthoDB" id="5308957at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="1">
        <location>
            <begin position="24"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF87960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="434" mass="50405" checksum="6E80E59909DBC35D" modified="2012-06-13" version="1">MSALDLEQLAMDTNPEGACRRPTPEDWAKMKNYIHEIYIKNNRSRKVLMQMMKRKGFDATPKMYTDQFKRWGAEFNKNQNSDEHDPDVELTKLYQELIFLTYDLAYPWTLNCLTDIPVYVYGLFDSFNLSANMFDVIVPVGTTDYSSVWQQIGAEIFGFITLLESNKTDEAWITYNIVGERLKSIVGVENDYGMIIKLWPICTRLLNAAVIYRDDSILFRFLHFLRRLVIQRYNKGGRDHPIPKLLTCLCQIPIGEFSKAIQMGYLKTIHCLENRLSFDNPLVQSTWSNYMNKCDRQALPVDVLTSRYSTVLQAARQSFTPTGTRTIEILHDYIYTAYYNAEDYQLTWNLAWETVRLAGSPELMREHPIWCKAMQSYALAVKLMYMISRDMGPRNLAVTELELAIKRLEGGDRECGTRAHMLKGILNRSERIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1S3G8</accession>
    <accession>A0A098DZS6</accession>
    <name>I1S3G8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG11350.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T21849</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_011327587.1"/>
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    <dbReference type="AlphaFoldDB" id="I1S3G8"/>
    <dbReference type="ESTHER" id="gibze-q4huk8">
        <property type="family name" value="Bacterial_esterase"/>
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        <property type="protein sequence ID" value="CEF86874"/>
        <property type="gene ID" value="FGRRES_11350"/>
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    </evidence>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325737.1">
        <property type="nucleotide sequence ID" value="XM_011327435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S3T0"/>
    <dbReference type="EnsemblFungi" id="CEF88147">
        <property type="protein sequence ID" value="CEF88147"/>
        <property type="gene ID" value="FGRRES_11477"/>
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    <dbReference type="KEGG" id="fgr:FGSG_11477"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <end position="270"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="EnsemblFungi" id="CEF88147"/>
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        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="354" mass="38093" checksum="50E8108649EAFE86" modified="2012-06-13" version="1">MYRASLSREAIVFGTMVSAVSAMVTGHAGRQLMPSMPEITADPMDFLDQVQLLQRRELQQRQEVSSPFDLTVTNAPDATCGYLSAEVGVPITCTNKEICAWALVQEDAGVIRCGTEIKVNCYESSKAVDPSLCNDVCQSDTMNLLCTNSDTPYCRTYAFPNGIRDYRCASSSLTAEQSAEHTFYGQKNPNFKTRVANGAVATTELEEALDKTATESDEPTTITKSAPSTKSASTDDNSKSSPAPIGAIVGGVVGGVALIGLAMLGVFFMLRRKRNKTVTTQGPINPPVMNFIPQNMGPSMLDSKMVASPHTQPDSAISPLQSDSRQSMFGPPPVYEAPGHESQVHEMGESSERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1S5X9</accession>
    <name>I1S5X9_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FGRAMPH1_01T15373</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321130.1">
        <property type="nucleotide sequence ID" value="XM_011322828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S5X9"/>
    <dbReference type="STRING" id="229533.I1S5X9"/>
    <dbReference type="EnsemblFungi" id="CEF79488">
        <property type="protein sequence ID" value="CEF79488"/>
        <property type="gene ID" value="FGRRES_12250"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12250"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15373"/>
    <dbReference type="eggNOG" id="KOG3468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154847_2_0_1"/>
    <dbReference type="InParanoid" id="I1S5X9"/>
    <dbReference type="OrthoDB" id="268414at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF79488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="86" mass="10124" checksum="E276BC25961EE482" modified="2012-06-13" version="1">MGSDAITEPRQATREEMRDAKLPLAYRDSCAHLLIPLNKCRRDTWYAPWKCSDERHSYEKCQYVEFKKRVAKMDELRESKGGARSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1S637</accession>
    <name>I1S637_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T14475</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </evidence>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblFungi" id="CEF77692">
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        <property type="gene ID" value="FGRRES_12539"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
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                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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    <dbReference type="EnsemblFungi" id="CEF76347">
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09089"/>
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        <property type="component" value="Chromosome 2"/>
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        </location>
    </feature>
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            <begin position="18"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="71"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF76347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
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</entry>
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    <accession>I1SA33</accession>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-ureidoglycolate = urea + glyoxylate</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
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    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_011320823.1"/>
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    <dbReference type="STRING" id="229533.I1SA33"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="UAH_cupin"/>
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    </dbReference>
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    <proteinExistence type="predicted"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF75542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75542"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="247" mass="26510" checksum="9A27026F4EFCE2DC" modified="2012-06-13" version="1">MSVKVNVGNLSLRVKTIPLTQEEFAPFGDVVYNPQPNLLPSKYASQGGRLPYSGTSANQGSAIRYADVSKPQDLLSQAPSKDGRLIMSQFVCEARTLAPAKDDPTQDEFAVNILERHPFTSQTFAPLASTASSYLVIVAPTLPPSSQDEGLPVPSGEGLPGRGLPDLKGLRAFIATDKQAVTYAAGTWHAPMVALGRKETTLDFLVVQFSSGVDIQDCQIVTFEGHDSKDADIKVRLPRSGNIVARL</sequence>
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    <accession>I1SA96</accession>
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        <submittedName>
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    <gene>
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    <organism evidence="2 4">
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319495.1">
        <property type="nucleotide sequence ID" value="XM_011321193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1SA96"/>
    <dbReference type="STRING" id="229533.I1SA96"/>
    <dbReference type="EnsemblFungi" id="CEF75939">
        <property type="protein sequence ID" value="CEF75939"/>
        <property type="gene ID" value="FGRRES_13777"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13777"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08271"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_604169_0_0_1"/>
    <dbReference type="InParanoid" id="I1SA96"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041617">
        <property type="entry name" value="TPR_MalT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17874">
        <property type="entry name" value="TPR_MalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MalT-like TPR region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF75939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="468" mass="52116" checksum="35D7422551168323" modified="2012-06-13" version="1">MHACLSLKANLKTQATPSAVGCQTISERGSVASSPAFSISNLNFSPRDITSIVSSPAAPSPVSSLGETTYPHNTTFAGQSPAPINQLSAAHSSASHSVVSNVVSNEQLPRRYQQDDEDRIREELSEAEDSLGINHSQTLELRISLGDVLVSQGRYKSAEETARRAIEDCRRLESNSAIMMDANDLLVGILCDQGSLYQAEKLAESAFESSKAILGEEHPSTLRSMVSLSRQYFRSRKLKDAEDLCARAIKISKKSYGERHTSTLEYMARLSFIYSEQGRLSDAEKLSLQALQMRTESFGKMHKSTLITMADVAYLYCLQGRSKDAEEMQVQALEMSILLFGEEHPDTLEYQMELVEIYVNQGQLNKAEDLCEQALMGRRKVYGEQHPDTLMAMNFMVRVYIGLRRFKEAEDLGAQVLIARKKVLGEQHPETLYTAGLMEEIYEAQGELARAEGSKEQEPVLEMDWRAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q4ICM0</accession>
    <accession>A0A0E0SHU1</accession>
    <accession>I1RM57</accession>
    <accession>V6RGA2</accession>
    <name>LIS1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nuclear distribution protein PAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lissencephaly-1 homolog</fullName>
            <shortName evidence="1">LIS-1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">nudF homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">PAC1</name>
        <name evidence="1" type="synonym">LIS1</name>
        <name type="ORF">FGRRES_05038</name>
        <name type="ORF">FGSG_05038</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates. Interacts with NDL1 and dynein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
            <location>Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle pole</location>
        </subcellularLocation>
        <text evidence="1">Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Dimerization mediated by the LisH domain may be required to activate dynein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LIS1/nudF family.</text>
    </comment>
    <dbReference type="EMBL" id="DS231665">
        <property type="protein sequence ID" value="ESU10945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323521.1">
        <property type="nucleotide sequence ID" value="XM_011325219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4ICM0"/>
    <dbReference type="SMR" id="Q4ICM0"/>
    <dbReference type="FunCoup" id="Q4ICM0">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="229533.Q4ICM0"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T16941">
        <property type="protein sequence ID" value="FGRAMPH1_01T16941-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G16941"/>
    </dbReference>
    <dbReference type="GeneID" id="23552234"/>
    <dbReference type="KEGG" id="fgr:FGSG_05038"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16941"/>
    <dbReference type="eggNOG" id="KOG0295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_15_1"/>
    <dbReference type="InParanoid" id="Q4ICM0"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051012">
        <property type="term" value="P:microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000342">
        <property type="entry name" value="Nuclear distribution protein PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.30:FF:000002">
        <property type="entry name" value="Platelet-activating factor acetylhydrolase ib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03141">
        <property type="entry name" value="lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017252">
        <property type="entry name" value="Dynein_regulator_LIS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037190">
        <property type="entry name" value="LIS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056795">
        <property type="entry name" value="PAC1-like_LisH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050349">
        <property type="entry name" value="WD_LIS1/nudF_dynein_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44129">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24951">
        <property type="entry name" value="LisH_PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037647">
        <property type="entry name" value="Dynein_regulator_Lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109925">
        <property type="entry name" value="Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0493">Microtubule</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000240426" description="Nuclear distribution protein PAC1">
        <location>
            <begin position="1"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="LisH" evidence="1">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="155"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="199"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="249"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="293"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6">
        <location>
            <begin position="355"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 7">
        <location>
            <begin position="399"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="460" mass="50451" checksum="031C2699095E9DC2" modified="2012-10-31" version="2">MSRTLTSRQAEELHKSIIAYLAANNLQDSANAMRTELGLGEDAFDTATAKKYETLLEKKWTSVVRLQKKIMDLEAQTQTLQTELNSATPTSNRRGDPSSWLPAGPPRHVLQSHRTPINCVAFHPIFSSIASGDEDATIKIWDWEFGELERTVKGHTKAVLDLDYGGPKGHTLLASCSSDLTIKLWDPANEYQNIRTLPGHDHSVSAVRFIPSGAPGAPLSGNLLASASRDVTVRIWDVTTGYCVKTIRGHADWIRDVSPSLDGKYLLSTGNDRTVRLWDISVPNPEAKLVMIGHEHFVECCTFAPPAAYSHLATLAGVKKPPPASSTAEFMATGGRDKTIRLWDGRGNCIKTLIGHDNWVRGLVFHPSGKFLLSVSDDKTIRCWDLSQEGKCVKTVEGSHEHFITSLRWAPPIIKDKGPGEETNGDVGTPKKAATAPQDVQIRCVIATGSVDMSLRIFSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q5I2J3</accession>
    <accession>A0A0E0RMY2</accession>
    <accession>Q4IQ69</accession>
    <accession>V6QUE5</accession>
    <name>TBA_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName>Tubulin alpha chain</fullName>
            <ecNumber evidence="2">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Alpha-tubulin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">TUB1</name>
        <name type="ORF">FGRRES_00639</name>
        <name type="ORF">FGSG_00639</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Wei Sheng Wu Xue Bao" volume="45" first="288" last="291">
            <title>Cloning of alpha-tubulin gene from Fusarium raminearum and analyzing its relationship with carbendazim-resistance.</title>
            <authorList>
                <person name="Chen C.-J."/>
                <person name="Li J."/>
                <person name="Qi Z.Q."/>
                <person name="Wang J.-X."/>
                <person name="Zhou M.-G."/>
            </authorList>
            <dbReference type="PubMed" id="15989278"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ZF43</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text>Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
            <location>Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="2"/>
    <dbReference type="EMBL" id="AY860418">
        <property type="protein sequence ID" value="AAW55660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DS231663">
        <property type="protein sequence ID" value="ESU05846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316331.1">
        <property type="nucleotide sequence ID" value="XM_011318029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5I2J3"/>
    <dbReference type="SMR" id="Q5I2J3"/>
    <dbReference type="FunCoup" id="Q5I2J3">
        <property type="interactions" value="1182"/>
    </dbReference>
    <dbReference type="STRING" id="229533.Q5I2J3"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T01613">
        <property type="protein sequence ID" value="FGRAMPH1_01T01613-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G01613"/>
    </dbReference>
    <dbReference type="GeneID" id="23548123"/>
    <dbReference type="KEGG" id="fgr:FGSG_00639"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01613"/>
    <dbReference type="eggNOG" id="KOG1376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015718_0_0_1"/>
    <dbReference type="InParanoid" id="Q5I2J3"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000008">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
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    <keyword id="KW-0479">Metal-binding</keyword>
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    <keyword id="KW-0547">Nucleotide-binding</keyword>
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        <location>
            <begin position="1"/>
            <end position="449"/>
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            <position position="254"/>
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        <location>
            <position position="11"/>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
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        <ligand>
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        <original>A</original>
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            <position position="82"/>
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</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>PH-1</strain>
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    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
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    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="FGRRES_01317"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03257"/>
    <dbReference type="eggNOG" id="KOG0911">
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:disulfide oxidoreductase activity"/>
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        <property type="entry name" value="TRX_PICOT"/>
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        <property type="entry name" value="Monothiol glutaredoxin"/>
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        <property type="entry name" value="GRX_PICOT-like"/>
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        <property type="entry name" value="Monothiol_GRX-rel"/>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
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        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="THIOREDOXIN_2"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="114"/>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00055846"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF73431.1"/>
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    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF73431"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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    </evidence>
    <sequence length="253" mass="27397" checksum="CD94D5E88033DEA1" modified="2014-02-19" version="1">MPTITEITSITEWEQLLGSVPPTTLVIVSFHAPWAAPCAQMATVLSTLASEYPDTEPPTTKWVSINAEELSDLSETYDVTAVPFLVLLRNGQVVETVSGSSAVKVRTAIETQAKQSGENAAASGPNGVAADDAVVEEEQDPEKKKEELFKRLGDLVKAAPVMLFMKGTPSSPQCGFSRQLVGLLRDNSVKYGFFNILADDEVRQGLKEFADWPTYPQLWIDGELVGGLDIVKEEMSNDAEFLTKYSVSAPAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>V6R4J1</accession>
    <name>V6R4J1_GIBZE</name>
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        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
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    </protein>
    <gene>
        <name evidence="5" type="primary">FG01476.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T03625</name>
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    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
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            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317285.1">
        <property type="nucleotide sequence ID" value="XM_011318983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6R4J1"/>
    <dbReference type="FunCoup" id="V6R4J1">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="229533.V6R4J1"/>
    <dbReference type="EnsemblFungi" id="CEF73618">
        <property type="protein sequence ID" value="CEF73618"/>
        <property type="gene ID" value="FGRRES_01476"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01476"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03625"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="InParanoid" id="V6R4J1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF73618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="342" mass="37532" checksum="AB2394DCE9D1731F" modified="2014-02-19" version="1">MTKVLLTGGSGFIAAHTLEQLLEKDYSIVTTVRSEDKAQKIRNAFPDKVKDGKLEIVIVTDIAKPDAFDQVAKTPGLDAVIHVASPFHFNITDPKKDLIDPAVIGTTGILKALHASAPNVKRVVITSSFAAIIDEAKFTDGSHVFSEKTWNPVTIDDITRSDTTAYRASKTLAERAAWDFVAEKKPSFDLVTVCPPLVLGPVSKHLATLESINTSNARIVNLLRGEWKDEIPPCTPVPLWIDVRDAARAHVRGLEEPSAGGKRLFTTAGLFSHREIVDIIAEKFPEFKDRLPGPEVKGGELPPKDQIFGIDNKETNELLKIDWLTVEKSMTDLVESLKEIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098CZE4</accession>
    <accession>A0A0E0RL43</accession>
    <name>A0A098CZE4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T00337</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF71968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098CZE4"/>
    <dbReference type="STRING" id="229533.A0A098CZE4"/>
    <dbReference type="EnsemblFungi" id="CEF71968">
        <property type="protein sequence ID" value="CEF71968"/>
        <property type="gene ID" value="FGRRES_20005"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00337"/>
    <dbReference type="InParanoid" id="A0A098CZE4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7580" evidence="1">
        <location>
            <begin position="3"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF71968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF71968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="195" mass="21874" checksum="0ED2AA7ACB9F897D" modified="2015-01-07" version="1">MAQIASSLAGAVLQYHSTPWLPVMWQSSHVRYFGMKDWLQDSTNLSLASPYFKVEFSKADIKGKGKAPETPMGPNLVIEEAVRNEVLFSFGLVLLELGYSKPWGLLRRSILGSLPLKKQADYHVAEDLAQSPLLRNRMGPRYATIIRKCLGCDFGLGENDLENEELQGIFLMDVVNALREAATGLRELERKLYSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-04-25" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D065</accession>
    <accession>A0A0E0RM29</accession>
    <accession>A0A1C3YI63</accession>
    <name>ATG11_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Autophagy-related protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ATG11</name>
        <name type="ORF">FG00382</name>
        <name type="ORF">FGRAMPH1_01T01003</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2017" name="Sci. Rep." volume="7" first="11062" last="11062">
            <title>Genome-wide functional analysis reveals that autophagy is necessary for growth, sporulation, deoxynivalenol production and virulence in Fusarium graminearum.</title>
            <authorList>
                <person name="Lv W."/>
                <person name="Wang C."/>
                <person name="Yang N."/>
                <person name="Que Y."/>
                <person name="Talbot N.J."/>
                <person name="Wang Z."/>
            </authorList>
            <dbReference type="PubMed" id="28894236"/>
            <dbReference type="DOI" id="10.1038/s41598-017-11640-z"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="1 4">Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy (By similarity). Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation, through its interaction with ATG32 (By similarity). Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation (By similarity). Required for ATG9 anterograde transport from the mitochondria to the PAS (By similarity). Also recruits the ATG19-prAPE1 complex to the PAS (By similarity). Required for the Cvt vesicles completion (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer and potential homooligomers (By similarity). Interacts with ATG1 kinase and the ATG19 and ATG34 cargo protein transporters (By similarity). Interacts with ATG9, ATG17 and ATG20.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole (By similarity).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Significantly decreases the radial growth of colonies under nutrient-rich conditions (PubMed:28894236). Strongly reduces conidiation (PubMed:28894236).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATG11 family.</text>
    </comment>
    <comment type="sequence caution" evidence="6">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="SCB64046" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64046.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D065"/>
    <dbReference type="SMR" id="A0A098D065"/>
    <dbReference type="FunCoup" id="A0A098D065">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A098D065"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T01003">
        <property type="protein sequence ID" value="FGRAMPH1_01T01003-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G01003"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QVZE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098D065"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019460">
        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000443901" description="Autophagy-related protein 11">
        <location>
            <begin position="1"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="574"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1205"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1333"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="540"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="616"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="842"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1106"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="575"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1206"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1333"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1384"/>
            <end position="1398"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q12527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="28894236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="28894236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72304"/>
        </source>
    </evidence>
    <sequence length="1429" mass="162227" checksum="B43E6FC9CF2E1734" modified="2015-01-07" version="1">MALQVLIAHTGLRLEVDTAQFSILDDLKTWVSKKTSIPPQHIVALNPHGRTVKITNLHTEKEIFVYDIRISSPGNTNLITPIPLPKRYAVPNAPNTIDDVQSITSWQELYKDRRNWAMRLVEDSGQMSSATLARYSEIDVIIKCLDAAVANLEISIKQIEPKYNDLKKWVAPALEEHGNLVERWEQYLDLAKSTPVSPSMVKFMTGREINKARPTLEDLIELDTAKKAGKLAPTAHRRFSDKANQLGNTASQMYQSLESLIANFETLMSRSALSHSTDSAQLLEDIEAVVKQMDSDYRAALGYGNTQRDVAQASKTASVHTEHLVPTLKKRVKEMEELLHYGTDARNSVASESAKFMRHVTEITSLHSNVKSQINVLNQSEDDMTTFDYLRLIHQLPYMYAAFVAEAVRRREWVDKVKTDSSTLANEMALFQDEESKRRRKWQKMIGSMYGPDLDTNVMGLEVNLLGEDTPWPALTKEDLTDFIQILQEQPVDQTVLDDIVKLVQELDSPTKQQSKRLKAFKNGSIHEAALGRSGLMIRGDDDLLQSLQEDKGKLENKLKTAESRVRRLEDLLHRQSQASRPGNLFQPQGSQQRERVNSASSVRSSRFDDRRRSSEGIDPLMRRITQLENELREEKQRSVNLQQELTTQSNNHEDVKGQHEDLKAQHEDLKGQMAEINTTKQDLLENMEALEREFVEERKNLEIEIKTLKARLEDTEDEIEQFDESRQHEKAGLVVRVEELEAELEQVNKQRQDDALKAQGQVEFLRKETRIQREQQEALEQQIQSAQEEVQNVSRKLSVAEEALDDHWQALTRLFSELSPDGTIPDNVVDLSNLLLTQAGTLVEKSRNSEADIELLKTQVEHFSSAISELREQVSQKDAKLSEDEMTVIHLRENIAEEQAKVSALEQELADGREQLTELRAKLSDGETGPEALQTRLEDEEKKVMTLTEEVASKQSHVGSLEEELRMFQEKVESLQGKISHMNSHYEHRDEKTKDLTQRLYSQNDRMCRLLERVGYAVTRKDGEMTVNKIPRAERNAQNLADSTDPSASIRKSGTLSRVLGDSVDLELLYWFNNSDMQAEDEKYEEFMNNLGKFDMELFSETVYRRIKEVEHMARKWQKEARSYRERAHILQKDSHEKIAFKHFREGDLALFLPTRNQQAGAWAAFNVGFPHYFLREQDAHRLRHREWLVARISRIQERVVDLSKSLQPSSETESINDEENDNPFQLSDGLHWYLIDALEDKPGAPSTPGMGKSTVAANTVEATANIHAHGVGGKGKSRESVTSIEGINKTLSKSLESRRSSTNSKKALPFQLGGTTLLKNSALASETNSLRAHNADTPSGTSPTQGGHLTSTNASLGQKNQRVDGPIRQPSDESSTQGGGAKADEQPRSVVQREDSVESPTRRSVVWDSLWSVDYNYESGSRRWLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-06-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D189</accession>
    <accession>A0A0E0RLS7</accession>
    <name>A0A098D189_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T00799</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
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            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
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    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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        <property type="gene ID" value="FGRRES_15900"/>
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    </evidence>
    <sequence length="787" mass="85852" checksum="E7DAE763A7534BA6" modified="2015-01-07" version="1">MASMPSATRPEDDKSTTTTPSPVDGQTVNLQVLSPSVGVTRPLLFPSLAANTTVKQLKDKIRQTLPLRPADENQRLIHRGRAIVRESDTLLDIFGADVIRNPEQQTIHLVIRDVQDSQPSAAAAAAPSAPSSLPAPASAPSSGPSPTASAPPTNPLRAQPQHPQGHVAGYQIPWRNSMPPTSNPFPQPRMPSPSPSHTPEQAAAFQHHHQNMTQWLNNLQREAMNRAINNSQRTRAQMGMRGVGDNVPGTVPVGDGSGRASPAPVPGQTIYREHVGPNGHTYQVETVVRTGGSGQQGSSGAAASMSPVDVHNIIRSADINQSASAVASAMQRSASSTSLHNRPLAQPGAPAPVYPHGYSIMSSRRGTPEPASARLAPTAASRNSQPRQGPEVYILSSPEGPRALLFNNTSSEAYYTPRLRTQTSLQQLQQLHQVQQLQQLNQLHRQTVAGPTQEVGIDQMQQRHHHHHHHHHNPRPPTAANYFNQLQAQPQPLRVNQRLQPLPQQPVHQGQAQPQPQVQGQGQGQGQVQNQGQEAEPGAFMGPLMHRGNPPMAALPPLLMQLWPQIWLLFRLALFVWFFTSPDASWYRWIAIIVIAVFIFVLSTGVFNGVPDHVWRPLGRHLENLIPLEPRPQQGVAVPEQHNQQNPQPRPNPDPTEMARRLVEQHQGPDNWILSQVRRLERAGLLFLASIAPGVAERHIANLEAAARAERERVEAEAREAAAAAAAAAQNDENNENPAENEGVGTTIGTEADQAERAPEDHERLRGEQGVQEGNQHGEHREPLIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D781</accession>
    <accession>A0A0E0RSS7</accession>
    <name>A0A098D781_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T04991</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D781"/>
    <dbReference type="EnsemblFungi" id="CEF74302">
        <property type="protein sequence ID" value="CEF74302"/>
        <property type="gene ID" value="FGRRES_15061"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04991"/>
    <dbReference type="InParanoid" id="A0A098D781"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF74302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="68" mass="7607" checksum="B19B725C7045A23D" modified="2015-01-07" version="1">MINQINYLLSTYPAIGCFAGNALDRNRHLDVSQQWPNSSRNMNNNTKVLAVRDTKSKPRVVIAQMGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D8I7</accession>
    <accession>A0A0E0RU40</accession>
    <name>A0A098D8I7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG02468.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T05921</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D8I7"/>
    <dbReference type="EnsemblFungi" id="CEF74765">
        <property type="protein sequence ID" value="CEF74765"/>
        <property type="gene ID" value="FGRRES_02468_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05921"/>
    <dbReference type="eggNOG" id="ENOG502SY2H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098D8I7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF74765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="122" mass="12883" checksum="45918FD9A18168EF" modified="2015-01-07" version="1">MGNTPASPSTSDSTEKKSLYRRYKDSKAPVPLSDEDIKKYTGKTREELGAWADSTPGVGKNQLAGRAMIGEASGLAGVAMADGYGGWGPSAEPNDVNRGMKFPPKPAEVPAEVVEVEAKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DK44</accession>
    <accession>A0A0E0S5Q2</accession>
    <name>A0A098DK44_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG03926.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T14049</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DK44"/>
    <dbReference type="STRING" id="229533.A0A098DK44"/>
    <dbReference type="EnsemblFungi" id="CEF78827">
        <property type="protein sequence ID" value="CEF78827"/>
        <property type="gene ID" value="FGRRES_16181"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14049"/>
    <dbReference type="InParanoid" id="A0A098DK44"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="80"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF78827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="294" mass="33808" checksum="8858CDD821FEF09E" modified="2015-01-07" version="1">MATPKSLALCVTCGTQFGIPFDERPSTCRMCNEPRQFVPPSGQSWTTLEKLQANYRNEFKQDEHDGRIWSIFSKPQIAIGQRAIFIKTEHGNVLWDCISLLDEGTIEFVKSHGGLKAIAISHPHFYSSHLDWAKEFDCPVYLAAEDQEWLNREDTEHRRVFFDGETQDILPGVTMVKLGGHFPGSSVLHWNNNIFTGDTIGISLSGLNRAHHNENHQVFFFHYAFPNFIPLGPTSMRLMWKRLRPWDFTSVYSLFFTTTVHEPNVKGIILESMKRQAMHQENDAHPLMQEQMEA</sequence>
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    <accession>A0A0E0S740</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DLG9"/>
    <dbReference type="EnsemblFungi" id="CEF79315">
        <property type="protein sequence ID" value="CEF79315"/>
        <property type="gene ID" value="FGRRES_15235"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15027"/>
    <dbReference type="InParanoid" id="A0A098DLG9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF79315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="83" mass="9558" checksum="BB1DF535DCF8F5FE" modified="2015-01-07" version="1">MYYLGSVLLYRSEANLPPKLKDKLTEWLTIGTPPGQATEDEQRERQLPLPFLELTTRNMTPCPKDTFRDSACCSKASLRQRKL</sequence>
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<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DMW0</accession>
    <accession>A0A0E0S706</accession>
    <name>A0A098DMW0_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
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        <name evidence="3" type="ORF">FGRAMPH1_01T14959</name>
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    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Hypocreales</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DMW0"/>
    <dbReference type="EnsemblFungi" id="CEF79281">
        <property type="protein sequence ID" value="CEF79281"/>
        <property type="gene ID" value="FGRRES_17618"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14959"/>
    <dbReference type="eggNOG" id="ENOG502S8G1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DMW0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF267">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="79"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF79281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="528" mass="57710" checksum="C9AA85A6C9199E12" modified="2015-01-07" version="1">MGVSRSRRQSLDCHAIPPSPQPSSAFEDIFDVDSPVSRPVSEAFMSGASTPNGSTSSRPPSLTEILLDVASPPWTLSAFMAYLSQNHCMESLEFTLDSQRYAAFYNEIITNNSNRTQEDNDRVCVLWEKLMQVYIIPCAPREVNLPARIRDQLLGLPCGPSPPHPAQLEEAGRILYELMNDSLLVPFLQSVAPMHVDGSTEEHGRGSRRSSNSNTRMGAPVRSMNSMHHHHEPESLTDDSDCNSTPGMEPMTPPTTPPTSEWAFTTSPGGLQRAVAAHNKGWKKMGAKLGSQVVSLPESSNEADWAHAISEETHETGGARFGPPLHGTLHAADDGWHHNPDLRQDGGFGNGTTAKFDTVRNGVKTSLVQKNIRMRRRSNKHHDFVATVQPLAGKHAAESHSTSYRHDLPLLSISPVCTGGNVQAAQVPMVDVSNYLPTPTTSSEDIGSPSTTSDHQAFRYASPVEDMYGWDAELERRRSPSRSSMSSNEGCDTIALSYRRANGSKHSLLQRVFRVSSSTSMAKMEAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DPM7</accession>
    <accession>A0A0E0SBK3</accession>
    <name>A0A098DPM7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG09086.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T27959</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DPM7"/>
    <dbReference type="EnsemblFungi" id="CEF83816">
        <property type="protein sequence ID" value="CEF83816"/>
        <property type="gene ID" value="FGRRES_09086_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27959"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DPM7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF83816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="555" mass="62708" checksum="3C4641F7C0B6E5C1" modified="2015-01-07" version="1">MTAYNNVTLSLWALFGALVLYLLTVPGRRGKHLPPGPPTLPIIGNLHQMPTRKGYLKLAEWAKQYGDMYSFKIGSTTTIVLSNRRLVKEILERRSVISAGRPAVYGLEKLVFGGHFILLQQPDAPMYRISKKLLHQYFGEPAIDRSHLRIINAEATQLIRDLMVDPDNFPHHAHRYANSFTMSTSESVRTHGKNTPLKYLAYGIRTPSHDTPHLTAITKITAQATSLIAPGRLPPVDVFPFLKLVPERILGNWVTLCTNLGKASDKLYMYILESVIERRKTKAPRDTFADRCLDNKEYEFSLHELMYLTGAVLDAGTDTTSSVLITLIQMLCAYPDCLKRAHAEIDMVVGDERTPVWDDFAKLPYINQLMKETQRIRPATPISFPHKVLEDIWIDGKLLPKGATIIANVTGLHSDPNKFKHPGEFHPDHYKGMQKLAQGYANTADENKRDHYAYGFGRRICAGMQIAERSLFTTFSKVLWAFDISAPKDAQGRPVAMNLDPMTGYTEGTIVMPKPFKACIKVRSERRRETILREFEEAENNVFAQFDLPKIGEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DQB3</accession>
    <accession>A0A0E0S9E5</accession>
    <name>A0A098DQB3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T25619</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DQB3"/>
    <dbReference type="EnsemblFungi" id="CEF83058">
        <property type="protein sequence ID" value="CEF83058"/>
        <property type="gene ID" value="FGRRES_15440"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25619"/>
    <dbReference type="InParanoid" id="A0A098DQB3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF83058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="54" mass="6026" checksum="8C0B3C3326C4F350" modified="2015-01-07" version="1">MGSGTAADYDHHPDANSILESPLFIRSDDDEAMDIWARIYIDKMDPTQLNVSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DQB4</accession>
    <accession>A0A0E0SAU1</accession>
    <name>A0A098DQB4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FGRAMPH1_01T24539</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DQB4"/>
    <dbReference type="FunCoup" id="A0A098DQB4">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A098DQB4"/>
    <dbReference type="EnsemblFungi" id="CEF83554">
        <property type="protein sequence ID" value="CEF83554"/>
        <property type="gene ID" value="FGRRES_17700_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24539"/>
    <dbReference type="eggNOG" id="KOG0234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DQB4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07040">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001280">
        <property type="entry name" value="Related to 6-phosphofructo-2-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF39">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE YLR345W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="4">
        <location>
            <begin position="44"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="465"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF83554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="503" mass="56582" checksum="7DF81840ADA9C1D0" modified="2015-01-07" version="1">MDTLLTAEIAANAPRYRRKSSTFIDAIHDIPHGQDLAPAQLYSTMSGRLFHSGRIVIVMVGPPARGKTHICVSMARYLSWLGVKSRIFHLGDYRRATVGPDGSIPDDYFFPNASPASVILRQKILKKCREDIYSWLNHDNGQVAIYDAVNPTANGRRSLAKEFAKHDVQTLFIESFVDDERILRENARNVKISSPDFAGMEPDEAAKLYLQRIEMKIPVFETMNEKELNYIKMINAGTKFFYNNVSFNYLAHRIVFYLTNLHIKSRKTFFARAGTTAEEDSYKADAPLSLEGRDYAQKMSEALLKHREQERLTTIAEGGTDAPLPPLTVWTSTRMRTVQTSDVLNEKGYKVRQRSQLSQINPGSYHDLAVRLEPIILELEREQTDLLIIAHESVLRVLYAYLMHCSTTDIPVINFPRDEIIEIVPAAYQNEAKRIHIPGLNPQIVPGSPQDIKIPVPSSGVVSAQLSPIPSGVGTPAEHAERPPEKVINTAKDMVADKVNDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DQL0</accession>
    <accession>A0A0E0SCI3</accession>
    <name>A0A098DQL0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG09117.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T27885</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DQL0"/>
    <dbReference type="EnsemblFungi" id="CEF84146">
        <property type="protein sequence ID" value="CEF84146"/>
        <property type="gene ID" value="FGRRES_17162"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27885"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DQL0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050829">
        <property type="entry name" value="CorA_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685:SF1">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1143"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1186"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="347"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="983"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="847"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="998"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF84146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1245" mass="141729" checksum="7021FB0EB5C16C42" modified="2015-01-07" version="1">MTQHGHQNVLQSPETVEDDQPNVKLNSNYLVSQDSTKTQDGVETTEQLFALEIQFMKSLPSQWVMHLKIQEKEKTPKPKILESAVFKISDNDKSEKYYDRLSDKPKIDASSPHVTFQLDPLDKSRLCLAILFRASHLPTFDLLFSRPGTEGDLVGVVVSGLHHLAPSKPTSDQTPFSWALACRWFDAFVGSDDETVLLWAAANGSLELMEHLKTHSADRFQHLLEHRDKEGRTPLSLAVRPDREIIVTFLLDAGADIRSEDNQKMTPLSWALSQLDPGYRFSSVRDMLRHYEISDDQPRLGKQKLLFQSARFGWVKAVIVLKILWDTDFDTVIPDEALHSEREAIYQGKTALCIAAEHGHRDVVAVLLDFGANVNFSTSNSECTPLMLAISGDVNEYLKAAVADVLITGGAEISRVNKAGHTAEHLAMNQGLQSVLNRLTWRSKDGTAAESVEQLNREVDDLFLATVTTFETEGDCLKRFMSKKHPIHNLLRKLDKAKEVQDITDVAFEWIHLPANNMRWIEVLISQLYKEKTQTYNILKPERWVRRQHHRGLDTSDATPDKPGVHHARFMRPICQAFPSSKDLRNKSKSLKIEKDQYDTNMVVFMPYLHWDITKNHTEREKVMKQTTHSTETNNEWSHDQKFLNAYLFYNKDSQNEPDPKHPSLERHYMHQPHVRRTLDQYYYHDLESTRERDRDQVLSRSACQKHLPAESKVLAMVDQLWLWVLAGKSGQPTTIVTCFPHKEAQSNDTSGGDTNKVADNAIDPDPSGETNIVKQVLSHMLDNPQSVITPHDLAKLITLKCSRTYLDIGGQDERLRFKEMYEMAIGDVMQKETELFNEFTAVMEETKKERKTNQSLKEQLKTLSEAASSETVEREKVKQSQADLIEKFETVFEELNNKSANQFVTSLFKSSRGRITQAKAETLLKLAQFQVLDITKEVQLLHEIKDVQDELRIMSMIFRDQKVIIDEMEEIIGAIPLKGAKRDSSVSQHQVTGDPIVNEHSDDSETATRAREKTPADGFDEKTDERRDPPFRERNSVHVGSDAFFTSTNGADSGLRGPTDYYIGNRAFFTSTRPEPGKASTSLDEKQRSVLSTRAVVKLSIDEIEDMIDGANNAYSAKQSNVMDARYARVQAEQSARQGKTIMVFTIVTIIFLPLSFMAAFFAIDISQFKRLKNGRLSLGYVSEIMFPISAFIIASLIYVAFKIDDFEWLWTINVPKWKRKKVVADLEKNQPSKAQEPEHQSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DS14</accession>
    <accession>A0A0E0SCI1</accession>
    <name>A0A098DS14_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T25129</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DS14"/>
    <dbReference type="EnsemblFungi" id="CEF84144">
        <property type="protein sequence ID" value="CEF84144"/>
        <property type="gene ID" value="FGRRES_07575_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25129"/>
    <dbReference type="InParanoid" id="A0A098DS14"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF84144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="690" mass="77345" checksum="BA44FBC0E6E6DB97" modified="2015-01-07" version="1">MTSTALARYACDYCRHKKFRCTRELPKCGECKPWPVPCNYSRDIPDTGTSSTTTAPLTNTKKSNDVQLRLQNIEKAIRDLTDVVNKAVVAINEVSSTSQKEELSFHTTPAEPDDSTSRLYVGKHNSFSVFEDAHNSVQKATGSLSTSLHHNAASELQFLSTSLTTTVTDNQLRGNSFYIPSKAQGYQLIGKFLESVCMGDAFFTAPSEELVLQVIFKPEGVSRKAWIVYINYMILAMLSEDQSTEAKGFRHNVKLALNDSKIFLEPHLVHLQTLILLAIHGEDYASPSLSWMLVGHACRQAEALGLHLSTESDSETHQRRLSLFWMLFAVDKSCSLAFGRPCFLPSTTYAKVALPDLGHLTRFQPRSDSADGRAQSSIFGAHMFLARMELASLEGDVLYLVNSEVLGTSRNQLREDLTEWHTRTNQVLHNIFNTERALSSPNQLREMSLGISTMNFEYLHVFMVLTRADASCVGSRLDAAREAISLLPSLVSNWTSIYNPMTWHLLYFPFIPFFVIFEDLVKGRASRTTTTKQHDIELLSTTVSYYSSLRDQFQLLAPLCERLKNIANVFRRFAVVLAGDRGTLGKDKELLQKFPGDGISHTRTLDSNFSMTFKEIQAELADEIGDDLKQYLEWLPSDILCVPSGSLGDVSSGNMTKETVNNFPSSAQVEGPRGTKRPFDVMFDWFAWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DUG3</accession>
    <accession>A0A0E0SDI5</accession>
    <name>A0A098DUG3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG07204.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T24225</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DUG3"/>
    <dbReference type="STRING" id="229533.A0A098DUG3"/>
    <dbReference type="EnsemblFungi" id="CEF84498">
        <property type="protein sequence ID" value="CEF84498"/>
        <property type="gene ID" value="FGRRES_16794_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24225"/>
    <dbReference type="eggNOG" id="KOG0806">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
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                <person name="Tetko I.V."/>
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                <person name="Waalwijk C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
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                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
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                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
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                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
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                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
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                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
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                <person name="Rep M."/>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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    </evidence>
    <sequence length="82" mass="9149" checksum="0132CC43CF61E186" modified="2015-01-07" version="1">MEKIMAIIRETIQSSGGIAMLSLAEKVLLAPESKNDGSLRCRWAEEQQEASQPLYLYNRQVNVGKSKQTDVERSGTIDRALP</sequence>
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                <person name="Goswami R.S."/>
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                <person name="Tetko I.V."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098E1E0"/>
    <dbReference type="EnsemblFungi" id="CEF87936">
        <property type="protein sequence ID" value="CEF87936"/>
        <property type="gene ID" value="FGRRES_20234"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16429"/>
    <dbReference type="InParanoid" id="A0A098E1E0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF87936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="131" mass="14094" checksum="9419CD11D32E6575" modified="2015-01-07" version="1">MTNAPGRPSKACDIFWSTITSGTVTTELVTVETIIPAVAPYYEACGLKALLSKSNGGNGVILTINGNLAYLPNTYTDANTLGGYNYCVECMRNPGCLLSQADGSMTFSSWVTLFRGPETFVISFETEKSFH</sequence>
</entry>
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    <accession>A0A0E0SP23</accession>
    <name>A0A098E256_GIBZE</name>
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            <fullName evidence="8">Chromosome 3, complete genome</fullName>
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    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T21851</name>
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    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098E256"/>
    <dbReference type="EnsemblFungi" id="CEF88186">
        <property type="protein sequence ID" value="CEF88186"/>
        <property type="gene ID" value="FGRRES_17567"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21851"/>
    <dbReference type="eggNOG" id="ENOG502RU0H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098E256"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
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        <location>
            <begin position="74"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF88186.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF88186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="404" mass="45360" checksum="A455FC60D7E6C169" modified="2015-01-07" version="1">MTASAFVGSPPATEDDLHIVKGVLRMYGLENFNASLGLSFSIQRPENPPIEKKVPEILTGMIIVILAIVLPTAARVIIRLRGARTRFGADDWAIICAASVAVVYPILCILMLFQTGAGRHTYESTYEEYNLYMYYLTVCKIIFYVAVGLIKVSITLFVRRLADRASRKWKIFSEVFLGTVICYILLALFWTVFSCRPLGTMWNKRYAGSLKEAPVCVDSVFQNRFLSSMHVAQSIVLLLAPIIILWYVKINKAKKARLFFIWLVGGTTVLGGLLQQTMITITNDSCWQYTSAMRWTVMDLTFGTLAASLPVLDAAIMGTWSSIKSKIGTTRSHSRTRTLGWTDLENGTRNTTTIKSVRRPSLSESESMENIRGGDKGMEMGILRTDEVELTYDEETRRRSLHAI</sequence>
</entry>
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            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
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    <gene>
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    <organism evidence="15 17">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="CEF88851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A098E428"/>
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        <property type="protein sequence ID" value="CEF88851"/>
        <property type="gene ID" value="FGRRES_12648_M"/>
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    <dbReference type="eggNOG" id="KOG3187">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 3"/>
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    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
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    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
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    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF88851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="235" mass="26546" checksum="D7BCDEC5A8AF7EBB" modified="2015-01-07" version="1">MNLTPPATMATTTKPQKASPYLFVYNTLFALVRIALFVRTTYLWTQQGNGAVWDELNVTARWTETFTVMEVLHAVAGLVRAAPATTALQVAGRNTIIWAITRNYPEVGFREDAYSFMLMAWNAADAVRYLYFTLQTGTGSVPASLTWLSDQIQHVYRALPCWYSFRDEACLRGYCTFSGTKPHISVSAVVWFGYLCPCILYPFWTHASSEGKVEPIYVQEAVLILSVDFVFKFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RWC6</accession>
    <name>A0A0E0RWC6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T07493</name>
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    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RWC6"/>
    <dbReference type="EnsemblFungi" id="CEF75551">
        <property type="protein sequence ID" value="CEF75551"/>
        <property type="gene ID" value="FGRRES_15583"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07493"/>
    <dbReference type="InParanoid" id="A0A0E0RWC6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF75551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="84" mass="9120" checksum="98460A11F9B42FF1" modified="2016-04-13" version="1">MPLRRYIRTFSLAHVRQASNGPWATETIRAHGRLSVITSVRNPLEPCSAASAKDIAESILDPYAVAEYVFGPGLGRAIPADTLK</sequence>
</entry>
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    <accession>A0A0E0S1U8</accession>
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            <fullName evidence="10">Chromosome 2, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0S1U8"/>
    <dbReference type="STRING" id="229533.A0A0E0S1U8"/>
    <dbReference type="EnsemblFungi" id="CEF77473">
        <property type="protein sequence ID" value="CEF77473"/>
        <property type="gene ID" value="FGRRES_16399"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11341"/>
    <dbReference type="eggNOG" id="ENOG502QR1M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0S1U8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
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    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF4">
        <property type="entry name" value="CONIDIAL DEVELOPMENT PROTEIN FLUFFY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="212"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF77473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="802" mass="88659" checksum="36F7AA026165FD70" modified="2016-04-13" version="1">MDVDNEHSDGGSQPPPSTEHTPQGASAQAGGASGNPTPTSVQSANTPSTASGNASTAAHPQNSKRRRGLGVVTPNACTECRKKRAKCDGKKPCGRCRAQKDVECVYEIPVRQSKENLRTEIETLRQKQRSSDQIFAALIRPELWEGVLTRLRGGQPIESISEWIASVPPSGGGPLPNFPDRPEGPTMGPGPGFPGGGLGTLAAMSLGVNQGPPQQPPIREMGQQSPWHSSFRSQTGSTRSSSYPDVMNWTPQNRVGSWAEGMHPEQMTDSLPRYRGVEQILSPLNEPELRTAASTWTSLTSDNTLVQHLLALYFCWEYPTFASLSKEHFLHDFQQGRNRYCSPILVNALLALGCRFSTQPMSRANPNDPYTSGDHFFKESLRLFSQETDHHSLTTIQALGIMSIREASCGRDSESWYYAGQSIRLAIEMGLHRIMDEGDEDELAVQSATFWGAFALDHAWSLATGSLPQCSCFPHLPPKPAIIGDIEASLWVPYTDDGAPLQRSCQQPSNVRSVYKCFCELSELVHQSLYILHSPGRPLTARELLNMYTQYLNWYDRIPEVLRLGHNFTPAVLFAHMYYHFAILLLFRPLIKLRIIGSKVSPRDVCSQAADAIQGLLRSYSSLYTLRRTPSFVPYFVLTSAIMHLAIGAISVNPEATEADVKKAVKVDPRAAEAITQGISDLTEMAPCHQFAEQALNILRYLAVKWNIDVENNVDKLTAEEYDRLVLPQTGSLNFFSPNMRHGDITCQWGTENFMPGTPKQSPSVQKVGDSLENPLFWPFPMQGRPILPDGIELEHAGFSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0S4F7</accession>
    <name>A0A0E0S4F7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 2, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="6" type="primary">FG03558.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T13157</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
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                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
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                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
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                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
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                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
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            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
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        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <citation type="submission" date="2017-01" db="UniProtKB">
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                <consortium name="EnsemblFungi"/>
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            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
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                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
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                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
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                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
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    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="FGRRES_20200"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SJ27"/>
    <dbReference type="STRING" id="229533.A0A0E0SJ27"/>
    <dbReference type="EnsemblFungi" id="CEF86440">
        <property type="protein sequence ID" value="CEF86440"/>
        <property type="gene ID" value="FGRRES_17516"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20503"/>
    <dbReference type="eggNOG" id="ENOG502R2EP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0SJ27"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF86440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="576" mass="61522" checksum="CF79731D6163FACD" modified="2016-04-13" version="1">MASSNPFRKSAAFTVDTATFPNSTSSAAVRFPALESFETASTPPPPTSFQQADASAIDHSSKVTKKVRVLSPPPLSPDPPEWAYTSPSLAQYAADQRGENDPFDATSTDDSDLEMVAATARNQALTGGQGAGNPFSKTMRDLDSPVVEQKLEQERKEEGHALKVANKAKQSLDVNSFKRLLMTGNSESDKALGQSEKDSKHHPSVFRRKSHEIQEASLIYASDIPEDEVGQESISDSSASARVNSKSSKKPPPPPSSRHGKSIKLNLVGNQTPPEALATLSPSEINKPPPPAHIRRSLDEEGESPFDREGASKSPGIDTSPGPLGGERKAVPAPPPRRGHARTESKANASQQSLQNDENLSRSSSMRTRPEHKRQNSQAGAPPPPPRRSHVSKHSIQLGMNSSFADLTQSSSSPAPSLDVDLSTTSTPSQLRQTSTLDLASPRDGHHPTSKSSAPPPPPARNTSVRRPASIRSVDSSRRVSFEAKPHNQMAPPPPPRRQRGSSKGSIDGPRRTSLDSVGKTGSSQVPEEEPDAVPEMIGSGHTSPKSTNEPGKSFDILADLDALQREVDALRGKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YHW7</accession>
    <name>A0A1C3YHW7_GIBZE</name>
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        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FGRAMPH1_01T02065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YHW7"/>
    <dbReference type="FunCoup" id="A0A1C3YHW7">
        <property type="interactions" value="879"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YHW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02065"/>
    <dbReference type="eggNOG" id="KOG1077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YHW7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000020">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="10">
        <location>
            <begin position="721"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="20"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="65"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SCB64128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="987" mass="110815" checksum="76B5661EF6B8A65D" modified="2016-11-02" version="1">MSSSGSGFLGRSSSSNANMRGLVQFIADLRNARARELEEKRINKELANIRQKFKDGSLSGYHKKKYVCKLLYIYILGWNVDFGHLEAVNLISANKYSEKQIGYLAMTLFLHEKHELLHLVVNSIRKDLLDHNELFNCLALHAIANVGSREMGEALNGEVHRLLISPTSKSFVKKKAALTLLRLYRKHPDIVSPQWAERIIHLMDDSDLGVALSVTSLVMTLAQDNLEQYKGAYAKAAARLKRILIDGEYTTDYLYYKVPCPWLQIKLLRLLQYFPPAEDTHVRDMIRESLQRILNLAMETNKNVQQNNAQNAVLFEAINLIIHLDTEHGLMKQISTRLGKFIQSRETNVRYLGLEAMTHLAARAETLDPIKQHQEIILGSLKDRDISVRRKGLDLLYSMCDATNAQVIVGELLQYLQNADFAIREEMVLKIAILTEKYATDVQWYVDISLRLIAMAGDHVSDEVWQRVIQIVTNNEELQVYAAQNALQYVKGDHCHETLVKIGAYILGEFGHLVADQPRCSPIEQFMALQGKLMACSSSTRAMILSCFVKYVNLFPEIKPQLVHVFEFHSHNLDSELQQRACEYLTLVNMQTDDLLRTVCDEMPPFPERQSALLSRLHQKHANTSDRRTWVVGGKDANADARELSMGTGALKRTFSSNMPLNGKPNGQAANAAGTNGHGNGVADLAGLDLNAPSPSEPKMLKAPNLASAAHLSPGWEQGFNKLLVRSDGVLYEDGQLQIGVRSEYRGQMACLITYFKNKTPATISSFTTTLDLDENEKSNLTWDVKNLPDSTIVQGGQSQQVVMFEAKKIFEKCPTVRISYLAGALQALTLKLPVAIHKFMDPAELTAEDFFKRWKQIGGAPREAQAIFGVNGKGDRQLTESFVTKTVEGFRWRVLDMVDPNPKNVVGASVLHTSQGGKFGCLMRLEPNYGQQMIRLTVRATDDSVPVVMLKYMQERLAAGISTSADRFEPPSREQISDSFRNVMVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YI33</accession>
    <name>A0A1C3YI33_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T02721</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YI33"/>
    <dbReference type="FunCoup" id="A0A1C3YI33">
        <property type="interactions" value="597"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YI33"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02721"/>
    <dbReference type="eggNOG" id="KOG2178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YI33"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000005">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000025">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="82"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SCB64182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="692" mass="75021" checksum="9C382555534E23CB" modified="2016-11-02" version="1">MTGLLSPTALHPALGSPRDRDDNGYSTMTLSPASIPLPLPSPSPLKKTTFADSLTLTSDSFQSQTEPDFEQHATDPLKPQPSLEDSTSTSASTSTLSSAQAQDQQKDTTLLSSSSLAASPSSLPPSTSDQTASWASSQYQAHRSNSGPRVSASVIRHHKPDALSLALPPSSSKMISTEASESDSQSHSQTASAAVPGLSSVLDNSSSATPSQSLTDALNDLAKSRLPTAGLTPTTARTYTSATSNDTAASDAAATILASTLQSPCFYHQRFADAVDIGKVLEEIKNDVSMSHSRLVATATGVREVSKQLQRRPIKRAVRNIMIVTKARDNQLVYLTRELAGWLLRTPRYGSDLGVNVYVDAKLRNSRRFDASGLLAENPRFQHMLKYWTPDLCWSQPEKFDLVLTLGGDGTVLFTSWLFQRIVPPVLSFSLGSLGFMTTFEFEKYKEHLNRIMGDDGMKINLRMRFTCTVQRNNRGAGALDAPKLEEPEQFEVLNELVIDRGPSPYVSNLELYGDDELLTVVQADGCIFSTPTGSTAYSLSAGGALVHPDIPAILLTPICPHTLSFRPMVLSDTMALRVVVPRNSRATAYCAFDGKGRLELRQGDCVTITASQYPFPTVTRTDTEWFDSVSRTLRWNVRAAAQKPFDADVAEDGKDDEEIGWDIDTDSACYASEDGSVSASPVRRQMSLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YIV6</accession>
    <name>A0A1C3YIV6_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FGRAMPH1_01T04003</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YIV6"/>
    <dbReference type="STRING" id="229533.A0A1C3YIV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04003"/>
    <dbReference type="eggNOG" id="KOG0585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YIV6"/>
    <dbReference type="PHI-base" id="PHI:1188"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000614">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000206">
        <property type="entry name" value="Serine/threonine-protein kinase Ssp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF152">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="128"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="281"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="701"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="849"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1014"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1172"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="714"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1043"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1059"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1184"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1224"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SCB64286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1251" mass="139629" checksum="1D4DA7E79C263E2E" modified="2016-11-02" version="1">MDSSQYYHNNHHHNSHRHHHKSLSQQQSSASLSSTNRGTPPLHTYLPSSASMPMPLRTANSTPMSSPGLFSPSASRQNLVTSVSENNTPPNYAQSPLLHPLQMHKVRETHKALIDSDTATGRKLINQYEVIEEIGRGMHGKVKLARNLETGENVAIKIIPRFSKKRRLGKVTAKSPQDKTKKEIAILKKIRHPNVVALLEVIDDPELKKIYMVLEHVELGEVVWRKKGLPHICLYERRRIEREMRGELPTPEEDRYEQLLEHRQAVKTLKRAKMAQKYPGQMNWSFENGGADEPSSSLGSRMSSMQDFAMSGSPPSRPTSRQTSREESRRHSRSRSIVSSTRAVEDPDEFINWEDDMETPLGLRSNPTSSTALDGTMYGPYVDEGFRGRSPSMADSIISHMSSLDFNPQQLDPFTDDFSYVPCFTFDQARSTFRDTVLGLEYLHYQGVVHRDIKPANLLWSKEHRVKISDFGVSYFGRPIRDGEFDDTVSESEAKDFDDDLELAKTVGTPAFFAPELCYTDLDTEQPRVSEQIDVWSLGVTLYCLIYARIPFLAEDEFQMFRKIATEEVYIPKRRLMPVHPSTSPAATSLYKRQNTHPYRDDNDLVYEEVDNRLIDLLRQMLTKNPEKRIRLRDIKRHPWVVHDIANPIGWLDDTDPARPSSGRKIQVDEREMSSAVVPLTFLERARSVVKKAVGKVMHPLVERSDSKTRHRANSSAASSAGDSVSMCNNGPPTPGQQYRDHRRKSLRPDDYFANAMRDSAPEHPLSVSTTVTPQPESVIYDPLATVLPEAGVSRGHVHAHSESESYREPEKSISAASLWPFHRHAHSQGYAKTTYHFLHFGPTAPISQTTPTTPSFASHADSQEDSGAETIRKTFDMDPVDSMDESSRSKSVDRGLFSTSDKRAEARVGVNTTVVPGNVQAPSRHGRQPIKSVDLGKMSHQRRLEASLLSSSLAGAAAGHRHSHSDTTYATDAHTVTKTRPRSLQRMDSAPITRTSPTRYSEELCMRRCDRPHSEHISFSCPPSPIEEEWDRDEPLPRADTMPTTKSSSVDSMEALATTPSTSPSEVTSPVSALPSTASTSERMLAFQSDPSLPALLSGASSVSADMEAELLCRPGIVSAHPQLLETTDSLTPPAFDKEPNGFPIDQIYGNQSAMNSGSLAVHLEGGARDSITSTPVARPVEDEYDYDDGSDDEDILVMAPKKKPIQSTQRPAAYPPKRRDTNISIASTETAKKVPTSTYGDEGTSPYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJ33</accession>
    <name>A0A1C3YJ33_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carboxypeptidase</fullName>
            <ecNumber evidence="15">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">FGRAMPH1_01T07391</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="15"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJ33"/>
    <dbReference type="FunCoup" id="A0A1C3YJ33">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YJ33"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07391"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJ33"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000121">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF190">
        <property type="entry name" value="PHEROMONE-PROCESSING CARBOXYPEPTIDASE KEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4 15" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008449359" description="Carboxypeptidase" evidence="15">
        <location>
            <begin position="29"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="527"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="478"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="563"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SCB64558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="619" mass="68800" checksum="909312A8DA0C14F5" modified="2016-11-02" version="1">MALMSMIPSPRRCVVLLSLSLTPTLVAAVNPATSTKAAAADYYVRDLPGLPADGPKVNMHAGHIEVTPESHGNLFFWHFENQHIADKQRTVIWINGGPGCSSEDGSMMEIGPYRLTDQDNLVYNNGSWNEFANLLFVDNPVGTGFSSVDTNSYIHELKEMADQFVIFLEKWFALFPQYDRDDIYIAGESYAGQHIPYIARAILDRNKKDSKTAWNLKGLLIGNGWISPAEQYPAYITFGIEKGIIEKDSDNHKKLQADLRSCEKMMASDVGHVDYGECEAILSNMLKLTKKGDGDDACINMYDVRLKDSYPSCGMNWPPDLVHLTPYLRKPEVTSALHVDAIKKSVGWTECNGAVGGAFNAKNSKPSVELLPNLLKEVPIMLFSGAEDLICNHVGTENMINKMEWNGGKGFEVTPGNWAPRRDWDFEGETAGFWQEARNLTYVLVYNSSHMVPFDLPRRSRDMLDRFMGVDISSVGGDPADSRIDGEKGPKTTVGSAKNSTQNAAEDEHQKQLDEAKWAAYYKSGEIVLVIVVIGAVAWGYWIWRERRKGAAYSVLADHDLSRRSTGHRAKSQPGDLETAAFDESELDDLHVTTPGTSTSARFPKNQDGSEKFVTKYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKI2</accession>
    <name>A0A1C3YKI2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FGRAMPH1_01T21665</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB65026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKI2"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21665"/>
    <dbReference type="eggNOG" id="ENOG502RX9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YKI2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF683">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="57"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SCB65026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="469" mass="49946" checksum="37F8312D8B204AD5" modified="2016-11-02" version="1">MDQNTQPTTESRDDLGNTPPKWKNGGYEDDSSHDAVFGEISSEGPDYRSVGLVGTAGLMMKTQIGLGVLSIPATFDALGLIPGVLCLIAIGLITTWSDCVIGVFKLRHRHVYAIDDAGAMMFGRAGGEFFGFIMWLNWVFVSGAGMLSLSIALNAVSSHGACTAIFIGIAAILGFGLSSIRTLGKMSWLAWVGVVSIVIAVLMVTIATGVQDRPDAAPQEGTWVSDYELFKTPTFVQAVSAVCAYVSAYGGTPGFFAIVAEMRKPEQYNTAVAICQSIVTALYVTVGIVMYYFCGSYVSSPALGSAGVVIKKASYGVAIPGLIVSITLVSHLPAKYMLVRFLRNTKHLTSNSAIHWATWLGCTFCVTIIAYIIASAIPIFYALVSLIGALLGSLLSFHAMGFMWFYDNWEKRSSSPRWLLACGWSIFVIAAGTVLMVAGTYGSILDIIKAYKATGGAGAWSCADNSNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YL45</accession>
    <name>A0A1C3YL45_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T24953</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YL45"/>
    <dbReference type="STRING" id="229533.A0A1C3YL45"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24953"/>
    <dbReference type="eggNOG" id="KOG1287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YL45"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF382">
        <property type="entry name" value="LOW-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="568"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SCB65272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="696" mass="77049" checksum="080BCCD8F1C32B0F" modified="2016-11-02" version="1">MDDFAAYRNQSRQAEPPQRDARAGDSDFDSLFEDDNPGQIYTSAPKEAFKLGYFDVMCLVLNRMIGTGIFNSPQRVMQGTRSTGATLLLWLAGVVYCLSGVHVYIEYGLNVPRYTINGIEQSVPRSGGDLNYLQYVYRKPAYRKGTVLLSTCMFGFCFIALGNMAGNCINFATMVLSASGNDDPSSGAVRGIAIGIAILTCFIHTFSRRGGIFLNNMLAIIKVMMLLLIIVTAIIVGAGGLKNADGKPVTKEIENNTRPSSAFAESGDANGYAHAFLAIIFSFSGFEQPNYVMGEISRPRRKHPVAMLLGVGTAILLYMAVNISYMVVVPSDDQIYDNVAQRFFELTLGSLNNSGTGKRIFHAFLAISSMGNIIVMTYTAARVKQEIAKEGIIPYAKFFAQDGDISLGRLLNWFKKRGMFSSLLSTRWLSPEDHMERTPVGAFVLHLASCFVLIFATWSMDPKSSYTLLTSLSAYVINAFFGTFLGLGILILRFKGPPKTDKDEIQSPAAPPQTWRQMTGKHINPTLSVICAVIYIIGGLWPIVTIWIKPNEPDQRPGKPDEQRLTWWLVPTITWSVIGGSVFWFLGFIAFAMRRKHKRNEIFVVEKKPEFESADGPDDSDGRTGGYVLVHETVYLSWIAGEIHESKGSGTTGFQERPDAMSAAPVNRYAGTDFEAFYQEERVAAPTKAYYSDYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YL89</accession>
    <name>A0A1C3YL89_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FGRAMPH1_01T23499</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YL89"/>
    <dbReference type="FunCoup" id="A0A1C3YL89">
        <property type="interactions" value="497"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YL89"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23499"/>
    <dbReference type="eggNOG" id="KOG0072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YL89"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04151">
        <property type="entry name" value="Arl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000624">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SCB65142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="180" mass="19988" checksum="DFB5EB5938A79E72" modified="2016-11-02" version="1">MGNSMSWFSNLLFSKKEIRILILGLDNAGKTTLLYRLKVGEVVTTIPTIGFNVESVTYKNLNFNVWDLGGQTSIRPYWRCYYANTAAVIFVVDSTDIERLHTASEELSAMLNEEELKDAALLVFANKQDQPGAKGAGEISEALRLGELRDRNWSIMACSAVDGSGVNEGMDWLVQTVNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMR9</accession>
    <name>A0A1C3YMR9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T12445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YMR9"/>
    <dbReference type="STRING" id="229533.A0A1C3YMR9"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12445"/>
    <dbReference type="eggNOG" id="KOG0159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YMR9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF190">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SCB65779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="484" mass="54820" checksum="D2ED0F689E2ADC4B" modified="2016-11-02" version="1">MAIPTSTLLAPAIIIFLILHVLLRALFSPFRTVPGPFLARFTDAWYFWNIRKGSFQQVNIDLHKKYGPIVRYGPNRYSINDPEAAKTIYGLGNHFPKSSWYSAWASPGQWAIFSDQSIERSTQNRKMYSATYAMSAQVHYEHFVDECTELFTQRLSELSTSDSNLFVDMRHWFQCYAFDVIGLITYAKRIGFLDRGEDVRGVIEALEDHMGYATLCGIFPSLHQFLFPLRNYLAGSKGAGRAYVVSFTNERIRESQTSPKPVAAENEVTTQDFLTKFLAKNLADPQNFTQHHVLMGCTSNMVAGSDTTAISLSALFYHLIKNPSCMEKLRNEIDQLTSRGELSKAPTFKESQQMTYLQAVIKETLRIHPATGLPLERVVPEGGATIAGRFFPENTIVGVNSWVAHRNKNVFGEDAEFGLGSRTCIGRHVSQLEMSKLVPRLIRDFNFELDPSLPGGNWSTWNYWFVKPVDFKVGISLREPKVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YNC8</accession>
    <name>A0A1C3YNC8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T15925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB66001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YNC8"/>
    <dbReference type="STRING" id="229533.A0A1C3YNC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15925"/>
    <dbReference type="InParanoid" id="A0A1C3YNC8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SCB66001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="647" mass="72661" checksum="8A63E3CBD802D069" modified="2016-11-02" version="1">MTTRSGSQTDGTRRACEPCRRKKSKCTGERPICSFCERLDLPCEYAARGSSMATQLKRATRIEKRSSTADRIRILESQVSSLSGLLTSVVREDAGSYDNNCTVSSRPGQDTDFAATPIVSDNYVFSGDSPNPPQSVLEHFVEVYSIKLHLQPLPLFELECLRSMLPVAAGYLRYSFLTLMLEFTSHSCYSSKYEEASTFYRHSAEAATQQLAGQGKPTADIMQALCMLALRNIAAGDLPRAWMSVGAAARLSTVGRLWHPKTINTREQDADNRCYWSIRMIESIFFPHISQDLKPDHTYKHPPSVDPPPPIPCDSNQINAPDFDDTGGTSRDAGINTHATSIISIWSQVASYLHDIRMGEVQVPWLPESTYSKLNLSLLEYEAQLHRKHLMRNLFPFKRSPEDVKACRQYWNPWLTTHLILHASLALLNHPFIHLVALRRNRGMSQSRLFLQQVVDQAIFHSGWVFWLVGIFEDLSVDISNPLIGLAVAATSTIPWLYQFVRNAKLAKKASQNLSKGQRLLERMSKTWPCLVRKLESLKELQALAMGTQLETGTTSTMIEFPPSMIWQLLDPIILPAELPGNVDNASTGSATRVSIHVTTDFLHPLEDDQEESPMNSLDWDDSLMCGNDFLQDIYPAALVPFDLNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>I1R9K3</accession>
    <accession>A0A098CZD2</accession>
    <name>I1R9K3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG00147.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T00399</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF71999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_011317450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1R9K3"/>
    <dbReference type="STRING" id="229533.I1R9K3"/>
    <dbReference type="EnsemblFungi" id="CEF71999">
        <property type="protein sequence ID" value="CEF71999"/>
        <property type="gene ID" value="FGRRES_00147"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00147"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00399"/>
    <dbReference type="eggNOG" id="ENOG502SHD0">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_033646_0_0_1"/>
    <dbReference type="InParanoid" id="I1R9K3"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="PHI-base" id="PHI:1990"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:zinc ion binding"/>
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    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
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            <begin position="1"/>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF71999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF71999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1R9N6</accession>
    <name>I1R9N6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T00511</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
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        <text evidence="1">Involved in pre-mRNA splicing.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ISY1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
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        <property type="term" value="C:U2-type spliceosomal complex"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
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        <property type="project" value="InterPro"/>
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    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="196"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SCB64003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="243" mass="28149" checksum="7CB45FB3FD6F9506" modified="2012-06-13" version="1">MARNSEKAQSMLFRFREAQAADLGIIDAGRTRRPKLITEVTTIPACEKWRGQVLKEISRKMSRIQEPILSDYQIRDLNDEINKLMREKHMWEIQIRNLGGPNYMRGGGKIYDDQGREIPGSGKGYKYFGRARELPGVKELFEAAKNQGDEKPLEERHDMRRNVDAAYYGYAPDEEDEELLAYEAEKERQAVDHMLKTGPRDVPDGWEALPGDTGDGNTWVLPTLEEVQEELIERRRRKLLEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1R9Q9</accession>
    <accession>A0A098D0Z9</accession>
    <name>I1R9Q9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG00214.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T00577</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315838.1">
        <property type="nucleotide sequence ID" value="XM_011317536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1R9Q9"/>
    <dbReference type="EnsemblFungi" id="CEF72090">
        <property type="protein sequence ID" value="CEF72090"/>
        <property type="gene ID" value="FGRRES_00214"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00214"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00577"/>
    <dbReference type="HOGENOM" id="CLU_1046025_0_0_1"/>
    <dbReference type="InParanoid" id="I1R9Q9"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF72090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="266" mass="30113" checksum="54C283D9F9EC6B98" modified="2012-06-13" version="1">MTPEAGEEEWVREQRLTQQLFGGGEVYFYRRMRRDDTLYIPTNMIATFTASYDAALALAEADLQEDLHPSPPSDTPSLSITPSPQDTPPHSETPSQSDTPAQSDTPAQSDTPSPSETSSQSEPPQPREIETICDIKRFAFSTDLLRKGPHLPTCFQKITNKINIYIILYRQPDIHCLWVLRVPENCKVSWTPRKGLEKHAYKSPSLADDIFRGLTRYNIMRGLVDDDTSSARPFFPYDHPGVEIRPALTILSRWSWGHMAVVRHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1R9U7</accession>
    <accession>A0A098D147</accession>
    <name>I1R9U7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG00259.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T00697</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_011317598.1"/>
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    <dbReference type="EnsemblFungi" id="CEF72150">
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        <property type="gene ID" value="FGRRES_00259"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00697"/>
    <dbReference type="eggNOG" id="KOG4419">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_019028_0_0_1"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:NAD+ catabolic process"/>
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        <property type="entry name" value="MPP_YHR202W_N"/>
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        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
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        <property type="entry name" value="5_nucleotidase/apyrase"/>
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        <property type="entry name" value="Calcineurin-like_PHP"/>
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        <property type="entry name" value="Nucleosidase_C"/>
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        <property type="entry name" value="Pesterase_C1039"/>
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        <property type="entry name" value="YHR202W_N"/>
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        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF43">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE FAMILY (AFU_ORTHOLOGUE AFUA_3G04160)"/>
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        <property type="entry name" value="Metallophos"/>
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        <property type="entry name" value="NadN_nucleosid_C"/>
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        <property type="entry name" value="Metallo-dependent phosphatases"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124030" evidence="1">
        <location>
            <begin position="21"/>
            <end position="606"/>
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    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="42"/>
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    <feature type="domain" description="Putative 5'-nucleotidase C-terminal" evidence="3">
        <location>
            <begin position="365"/>
            <end position="568"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF72150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="606" mass="68241" checksum="DCCA705DA7B1CFC4" modified="2012-06-13" version="1">MILRSKTLAAGSALVAVARASQPGAAAPVPGPMRDLTWGQINFIHTTDTHGWIGGHLQEPQYSADWGDYISFTKHMRDQADKRGSDLLVIDTGDRIEGNGLYDASTPKGLFQYDIYAEADVDIMSTGNHELYKAYSADMEHNTTVPNYKNSYLASNLDYISFETGDRVPQAPRYKKFKTKNQGLNIVAFGFLFDFTGNANNTVVQPVEDTIKEDWFQEAIHEKPDLFVVIGHVGLRMEEFKVIYTAIRKQNWHIPIAFFGGHAHVRDTVQYDSKALAIASGRYFETIGWMSIDGIKKGGAKDVEAAASPTFTRRYIDNNLYGLHYHTGLNETTFSTENGKRVSKMITRARKALQLDYTFGCAPKTLWMARAKPTDEDSIYHWISNHLLPDVITRKDRKDKSRLAIFNTGGIRFDIFKGGFTRDSTYAVCPFDSGFKYIPDVPYKAAAKVIDLLNSAGRIFAENGLDVKYMAMPEQAFPAPVMKAQFERNKIDAEESRLELRSLFDKPDLTAGYTTIDDIGADGDDTIHEPVKFYQQPNCVQAEINMPKDGEPETVDFVFLDFIQPWIIPALRLAGAGHFSDADVERYIEGSFTYHMADWISKNWQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1RA46</accession>
    <name>I1RA46_GIBZE</name>
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        <submittedName>
            <fullName evidence="6">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG00370.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T00979</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316032.1">
        <property type="nucleotide sequence ID" value="XM_011317730.1"/>
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    <dbReference type="AlphaFoldDB" id="I1RA46"/>
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    <dbReference type="STRING" id="229533.I1RA46"/>
    <dbReference type="EnsemblFungi" id="CEF72292">
        <property type="protein sequence ID" value="CEF72292"/>
        <property type="gene ID" value="FGRRES_00370"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00370"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00979"/>
    <dbReference type="eggNOG" id="KOG0108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028601_0_1_1"/>
    <dbReference type="InParanoid" id="I1RA46"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd12398">
        <property type="entry name" value="RRM_CSTF2_RNA15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.70">
        <property type="entry name" value="Transcription termination and cleavage factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026896">
        <property type="entry name" value="CSTF_C"/>
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    <dbReference type="InterPro" id="IPR038192">
        <property type="entry name" value="CSTF_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14304">
        <property type="entry name" value="CSTF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF72292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="294" mass="31434" checksum="EDC4042B578D4951" modified="2012-06-13" version="1">MSTRPPSRVVFVGNIPYGLTEEQITEIFSSAGKVERFRLVYDSETGRPKGFGFADYPDTDSASSAVRNLNDHEIMGRKLRVDFSNEQKGSDDDKDPSTSGYSMHASNGAATNYNAQPSTLPPLPSGKELPPGVSCTDSISRTLQTLPPAQLLDILSQMKTLATNDPQRATELLQQAPQLGYAVFQALLLMGLVSPEAIQSVVEPGAPPPAAFPPAPMPGFPGVSNTPPVAAMPYQAPPQQYAAPPPAAPAPVAPDQDALMRAVMELPQAQIDMLPEAERQQILALRATFGGQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>I1RAH4</accession>
    <name>I1RAH4_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">DNA replication licensing factor mcm4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">FG00504.1</name>
        <name evidence="18" type="ORF">FGRAMPH1_01T01289</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="19">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="19">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316178.1">
        <property type="nucleotide sequence ID" value="XM_011317876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RAH4"/>
    <dbReference type="FunCoup" id="I1RAH4">
        <property type="interactions" value="996"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RAH4"/>
    <dbReference type="EnsemblFungi" id="CEF72445">
        <property type="protein sequence ID" value="CEF72445"/>
        <property type="gene ID" value="FGRRES_00504"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00504"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01289"/>
    <dbReference type="eggNOG" id="KOG0478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_7_1_1"/>
    <dbReference type="InParanoid" id="I1RAH4"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="PHI-base" id="PHI:1562"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000011">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="17">
        <location>
            <begin position="601"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="327"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="64"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CEF72445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1020" mass="112421" checksum="C36A0F53C6037CD0" modified="2012-06-13" version="1">MSSPTKRSTRSSATPRRSGRNPEPNQASGPGNSQLEVPSSPLPYPSSSPGPSGQNDLPRGVSSPFAQMMSSQSTRARSNIPSSPFHQMTESQSDIDPQRTPRANPTTPAYHGGSSPVRYDPSSSPGRSLRHQSELRSEASGLFVGSQIGSPAPHRRGDINSDAARTPRASRRVILDDVGRVVREGPADGSDVASFANRDPNTSEADVLGGQGQSLIWGTTVSIDDTFASFKDFLRNFTQKYRMYRDGASDEDVQNDPDAESKPYWEALENMLLLGTTRLYLDISDLNLYPPTRKLWHQIQAYPQEIVPVMDQSVHDMMVEIARTETMRNRSQSTAGHQASQHSTQSSEPNFPSSDRPEEAPTPRAQPDQQQASLEDQVASSIYVLRPFGLDKTTNLRDLNPSDMDRLISIKGLVIRTTPVIPDMKDAFFRCNVCNHSVNVGLDRGKIREPTECPREICKSKNSMLIIHNRCSFEDKQVIKLQETPDAVPAGQTPHSVSVCVYNELVDFCKAGDRVELTGIFRVSPVRVNPAQRAVKSVHKTYVDVLHIQKVDKRRMGADPSTLGIAGEEDAEAGENGIEETRKISIEDEEKIRETAARDDIYDLLSRSLAPSIYEMDDVKKGILLQLFGGTNKSFQKGGSPKYRGDINVLLCGDPSTAKSQMLSYVHKIAPRGVYTSGKGSSAVGLTAYVTRDPETRQLVLESGALVLSDGGVCCIDEFDKMSDATRSVLHEVMEQQTVSVAKAGIITTLNARTSILASANPIGSRYNPDLPVPQNIDLPPTLLSRFDLVYLMLDTADEKNDRRLAKHLLSLYLEDKPQSAPTDNDILPVEFLTLYISYARSKIQPVISQEAAQELVECYVAMRALGQDVRSADKRITATTRQLESMIRLAEAHAKMRLAETVTRDDVREANRLIQSALKTAATDANGRIDMSLLTEGTSAADRKRREELRTAILHLLDEMTAGGNTVRWGDVFRRLSEGASIPVEQSEFNEVMRALEAENALMIMGEGARRTIRRVNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1RAS7</accession>
    <name>I1RAS7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG00613.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T01559</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316304.1">
        <property type="nucleotide sequence ID" value="XM_011318002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RAS7"/>
    <dbReference type="FunCoup" id="I1RAS7">
        <property type="interactions" value="224"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF72580">
        <property type="protein sequence ID" value="CEF72580"/>
        <property type="gene ID" value="FGRRES_00613"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00613"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01559"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_0_1"/>
    <dbReference type="InParanoid" id="I1RAS7"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="100"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF72580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="603" mass="65961" checksum="F72AEEE6755E0C9A" modified="2012-06-13" version="1">MAPHDVERGSISKMKEESLAPGSSFSMREPEYADILPPSYWGRFVDGFRRDQRSSLFTNDPLGQQEGLGRVHDGAHYYDLQSAMLETANSGLARELKGRHLQMIAIGGSIGTGLFVASGRALADGGPASILLAFTIVGAMLFCTCQALGELAVIFPIAGSFSSWATRFIDPSWGFAMGWNYAMQWLIVLPLEIIAASLTLSYWDESLTRAIFVSAFLVLIIVINMFGVKGYGEAEFIFSIIKVIAVIGFILLGIVLNCGGTPDSGYIGGRFWHEPGAFNNGFKGMCNVFVTAAFSFAGTELIGLAAAETANPRKSLPTALKQVFWRITLFYIVALTLVGLLVPYNDPRLTKGTSDADAAASPFVIAIEEAGIQVLPSVMNAVILCAVLSVGNSAVFGSSRTLAALANLRQAPKILGYVDRKGRPLVAIAIASAFGLIAFLADLPQQGAVLDWLMSISGLSTIITWGSICVCHIRFRRAWAARGRSVSELPFQSQVGVVGSWIGITLNVLVLIAQFWVGAFPIGWQDLTSSQVAQNFFHKWVGAPCVLAFYIFHKLYFRTTFVRTRDMDVDTGRRDFNVPILVAQEKQERARWPRWKRYYKFMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>I1RB41</accession>
    <name>I1RB41_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG00746.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T01885</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316455.1">
        <property type="nucleotide sequence ID" value="XM_011318153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RB41"/>
    <dbReference type="FunCoup" id="I1RB41">
        <property type="interactions" value="661"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RB41"/>
    <dbReference type="EnsemblFungi" id="CEF72743">
        <property type="protein sequence ID" value="CEF72743"/>
        <property type="gene ID" value="FGRRES_00746"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00746"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01885"/>
    <dbReference type="eggNOG" id="KOG0010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024293_0_1_1"/>
    <dbReference type="InParanoid" id="I1RB41"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14324">
        <property type="entry name" value="UBA_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16106">
        <property type="entry name" value="Ubl_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000024">
        <property type="entry name" value="Ubiquitin domain-containing protein DSK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="401"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF72743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="445" mass="46426" checksum="8B3B1CE2C06CC4B2" modified="2012-06-13" version="1">MTDNPEPSSDSQITFKVKTSSEGHQTITMSETATVLDLKTKLAGEDFENIPVERQRLIYSGRVMKNDDTLSTYKIKNNNTIHMVKSAASNQQPNQTPTASASTATPAPTNMAAGTANQPFAGLTGARYAGFGNGLPGLDMFGPDGGMGAPMDEARIQRLMSDPNVQSSMNEALNNPDFINMLIDSNPMLRNLPNAREIITSPVMRQMMSSPEMMTQAMRMQRQMNGGAPGAFPAPGATDTTPQGADTQGTSGQTQADQPPANPFLGLSGLLGQQGGGNQPDFTQIMQQLQGLGSLYGAGGQGQAATGQTGSANTPSQGTTDSAAGAQTSGTTPGQGGEQQGSTTSPPPANPFAALFPPSGGAQANNPFGMNPEMMQQMMQMFGGGGMGAAANPPAPADNRPPEERYAEQLRQLNDMGFFDFDRNVAALRRSGGSVQGAIEHLLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>I1RBU5</accession>
    <accession>A0A098D3R8</accession>
    <name>I1RBU5_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">DNA repair protein REV1</fullName>
            <ecNumber evidence="16">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">FG01035.1</name>
        <name evidence="21" type="ORF">FGRAMPH1_01T02591</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="22">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="23">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="22">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="21 23" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="21">PH-1</strain>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="16"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316789.1">
        <property type="nucleotide sequence ID" value="XM_011318487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RBU5"/>
    <dbReference type="FunCoup" id="I1RBU5">
        <property type="interactions" value="859"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RBU5"/>
    <dbReference type="EnsemblFungi" id="CEF73097">
        <property type="protein sequence ID" value="CEF73097"/>
        <property type="gene ID" value="FGRRES_01035"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01035"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02591"/>
    <dbReference type="eggNOG" id="KOG2093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003901_1_1_1"/>
    <dbReference type="InParanoid" id="I1RBU5"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01701">
        <property type="entry name" value="PolY_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000040">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000011">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1280">
        <property type="entry name" value="DNA repair protein Rev1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012112">
        <property type="entry name" value="REV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031991">
        <property type="entry name" value="Rev1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038401">
        <property type="entry name" value="Rev1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16727">
        <property type="entry name" value="REV1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036573">
        <property type="entry name" value="REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 16" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="11 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="60"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="20">
        <location>
            <begin position="361"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="852"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="903"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR036573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR036573-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CEF73097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1143" mass="127191" checksum="C1331760F9C83464" modified="2012-06-13" version="1">MGSVLDKNSSQVRKRIEAHTFENEGGDEYEGSEFGGFNDYFRRKKIKLQNLDAETRAKSDKPQIFKGIVAHVTGYTQPPLHVYSLHREIVQHGGGFLQYLDSKTMATHIIASTLTPKKSVDFGRYRIVKPAWIMDSIQAGQLLPWSNYRVLDEGPRQKVLTFDGSSGLAPSTPRAKQGYREQSENSFYTGQFKVPALPSQSLGQVIEKAQTPIHGMSRALGTTPMEGVDSPSFKKPEAPPGSPVIGQSIATPCRLVTNKDDHDNTMPQGEVVSAPTLLTKAREPSKPMTSEEHNAQLLSDPRIRKSSTANPDFLKQFYSESRLHHLSTWKAELKSRMQRLAVEKGQSTLNTKKRPNSRRYVMHVDFDSFFCAVSIKKKPELINKPAVVAHSIGSGSEIASCNYPAREFGVKNGMWMKSALELCPDLKVLPYDFPAYEKASRLFYESMLDIGGVVQSVSIDEALIDITSVVMKSAGSQGMGPDSENIALERDMAGKIAKDLREKIKSLTDCHVSVGIGANILQAKVALRKAKPAGQYQLEPGDVLDMIGDLKVEQLPGVARSIRGKLEDIGVVLVKDLREVSKERLVSILGPKTGEKLREYALGIDRTEVGEQPPRKSVSAEVNWGIRFINQPEAEEFVYNLCKELEKRLLNENVRGKQFTMKIMRRSMDAPLDPPKSLGHGKCDTFNKSTTFGVATNDQQVIGKEAVNILRSFKFSPGDLRGLGVQMTKLEPIKTNLAAPGGSQKRLAFSAFTKSSPAKKDSTAEQIDEFESPEKQKAMPGLGVSNDPIADDPLTPRKQKIHPAMALTKASQDDVKAKTPLNISGTQFIIPKDVDHAILAELPSSIRNKLMAQKSRIPQEAESPIPKSRSESPMPFDVCPTQVDPDVFNALPDDMKAEIMATYGRKPKQPTPHQSPRKDRTIQPRKPTTPSKRGRPRGLFGKAQRQRDAQAGLLQTNFRSLNEVGDAFQEEDVVEELDSEFLAELPEDVRKEVIEDHKRRKKVQQTNLEAPLRKQNSIDTDVALPGGQLRIQFATLPRKISFASSGVTSTQEIKDMLDAWHSETRKNGPHRGDIEVLEKFLERVVQEERDLEKATKLVKWLDVLVEQDGRKGRGQETWRRSVEGIKVVVQQAVKQRGMAPLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1RCH1</accession>
    <name>I1RCH1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG01286.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T03185</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317068.1">
        <property type="nucleotide sequence ID" value="XM_011318766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RCH1"/>
    <dbReference type="EnsemblFungi" id="CEF73395">
        <property type="protein sequence ID" value="CEF73395"/>
        <property type="gene ID" value="FGRRES_01286"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01286"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03185"/>
    <dbReference type="eggNOG" id="ENOG502RNKZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1235114_0_0_1"/>
    <dbReference type="InParanoid" id="I1RCH1"/>
    <dbReference type="OrthoDB" id="5080160at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF73395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="224" mass="24287" checksum="EC766AA00D409A3B" modified="2012-06-13" version="1">MENTRSAADTSAWQIKDHLLAILPAGVLFGATVAMRLPQHPHLDVVARLGRVAILVALGCAISRTRFFAETPTSLNDLPTILREYIFLMGVVVFVVAMMAPSADEPRQPSDSIINEERMLVPEPRNTRCKPGTKQSWDIASSISHLDLLSNLGSLDLKFMPGPKSHYSDLSGSGESAVTLSSGLIRDPSKLMEIIQWVKAAAPPSFGRKGDSTSTENVLHEVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RDG5</accession>
    <name>I1RDG5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG01661.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T04045</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317486.1">
        <property type="nucleotide sequence ID" value="XM_011319184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RDG5"/>
    <dbReference type="FunCoup" id="I1RDG5">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF73830">
        <property type="protein sequence ID" value="CEF73830"/>
        <property type="gene ID" value="FGRRES_01661"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01661"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04045"/>
    <dbReference type="eggNOG" id="ENOG502QT05">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_0_0_1"/>
    <dbReference type="InParanoid" id="I1RDG5"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000907">
        <property type="term" value="F:sulfonate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044273">
        <property type="term" value="P:sulfur compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="97"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF73830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="380" mass="42535" checksum="48349C62E5F92BCA" modified="2012-06-13" version="1">MAPSAVETTTNPVSETPKVKLYSGHVEGAYKELSPTSYIRESEEKGIDGHAAAKYPNYLPTWNTDQVYPPLEPFEHYEHGKDADPSFSNLLTSDSKVSHLTPTIGTEVEGVQLSSLSDAGKDELARYVAERKVVAFRNQDFADLPISEALKFGGYFGRHHIHPTSGSPEGHPEIHLVHRSAGDKSYEDFFKTRVSSVAWHSDITYEQQPPGTTFLYVLDNPDTGGDTLFANTVEAYNRLSPTFQKLLHGLKATHSGIEQVNASVKKGSIKRREPVVNEHPIVRTHPVTGEKSLYVNPQFTRSIVGLKKEESDAILNFLFEHIAWGADFHARVKWAKGTVVVWDNRSVQHTAILDWHSGQRRHLARITPQAERPYETPFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>I1RDL5</accession>
    <name>I1RDL5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG01724.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T04197</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317557.1">
        <property type="nucleotide sequence ID" value="XM_011319255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RDL5"/>
    <dbReference type="STRING" id="229533.I1RDL5"/>
    <dbReference type="EnsemblFungi" id="CEF73906">
        <property type="protein sequence ID" value="CEF73906"/>
        <property type="gene ID" value="FGRRES_01724"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01724"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04197"/>
    <dbReference type="eggNOG" id="ENOG502QVYJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010170_0_0_1"/>
    <dbReference type="InParanoid" id="I1RDL5"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="PHI-base" id="PHI:1951"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF9">
        <property type="entry name" value="TAH-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF73906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="665" mass="74275" checksum="EB3F54C5BCEC130D" modified="2012-06-13" version="1">MPTKKVDSSMRRRCAMACENCKRRKERCDGNVPCRRCAARHLDAECHYSKSRGGFSSRQNANIQLRSPLESLTDSILNPVAETKSQTADQAVSQSMSFFPDLDTTFPHVCRLARDDQRGSVFFGESANESFLQQIRQLVARTLGSCPFVDQPIQYHTYHDTSTSPFTSLDEVPKPPPKPSPARASFLWLGQHGESTSLSTALCYLILANGALACSEDEDATANAYFSYARYLTNLELTEEPSLESILCHSLIAFYQLNIGRRDAAYQSVGLACRGACSMGIHRVNQPSLMSHESYAFRDRLWKALRMLDIFTSGSLGRPVCTTENRNTKVEQGYSSVIDITAILDDVLREAHRPTKPIRNFIARMTQEHRLWAARMPRGLQADGFESAELGEGCECVPSLILSNIKESYYWSIMLLTRPVLLERASTQTIRVGLGQGHYGDQAEVPPISNSDTALVYASVNSAVRTIRLLQCLLSREDLPKRLPFPVNSAFTAALTLALATFADLDCVFPLQANLETVEKILQRFEKHDSIARYYRHVVEQLQFTCDEYIEKRNNRIMEKQNHMVDDLFGRLHEEPLLSKEKSGSMDVRWIDKPAITQEPLSGSPTGSSSTICLTDESLAGADALDVSGSFLDLPLDLSQGSQMSDMYFIGTGLDMEVLNFSNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RE24</accession>
    <name>I1RE24_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG01897.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T04583</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317746.1">
        <property type="nucleotide sequence ID" value="XM_011319444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RE24"/>
    <dbReference type="STRING" id="229533.I1RE24"/>
    <dbReference type="EnsemblFungi" id="CEF74098">
        <property type="protein sequence ID" value="CEF74098"/>
        <property type="gene ID" value="FGRRES_01897"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01897"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04583"/>
    <dbReference type="eggNOG" id="ENOG502S4E5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110291_1_2_1"/>
    <dbReference type="InParanoid" id="I1RE24"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF74098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="149" mass="15882" checksum="8ACF5DCC77AE00DA" modified="2012-06-13" version="1">MSLVLELPAEYGYVLVAATSTFFINTLHVVLTSKARKQSGLKYPIPYASNDLAEKNAEAYKFNCAQRSHANFTENQISFLGALLISGLRYPVASAVLGAGWAASRVFYAIGYSAGGPQGRMGGSIGSALCDVSLKFMAAYTSIMYAMGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RE68</accession>
    <name>I1RE68_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG01944.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T04695</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
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        <property type="protein sequence ID" value="CEF74154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="229533.I1RE68"/>
    <dbReference type="EnsemblFungi" id="CEF74154">
        <property type="protein sequence ID" value="CEF74154"/>
        <property type="gene ID" value="FGRRES_01944"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01944"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04695"/>
    <dbReference type="eggNOG" id="KOG2946">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_059592_0_0_1"/>
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    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:trans-Golgi network"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
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    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF1">
        <property type="entry name" value="PROTEIN YIPF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="165"/>
            <end position="183"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="213"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="238"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="162"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF74154.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF74154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="299" mass="32391" checksum="AE9076883F15B1D3" modified="2012-06-13" version="1">MSASSARGHYANPPLEDEDDLIDPDDADLNDFDDPLATNNPRQPLTGNIGSSSSSRPLNEGYLTSRIPGEDRAAPLNTIDESVWDTLRRDLLAVWAKLREVLYPRYLLGGTMFDSEGGIRGAYSSIRGAGLSGTREELTGLASRMVDAEALLQSNMTPGLRDWDLWGPLIFCLLLSVLLSFTARSEQRDAVFSGVFAMIWLGEAVVTLQIKLLGGNISFAQSVCIIGYTLFPLVLAAMMSALGLHWIARIPIYIVLIGWSLAAGVSILGGSGVVKNRVFLAVYPLLVFYLGLGCLCFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1RFX3</accession>
    <name>I1RFX3_GIBZE</name>
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        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG02617.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T06279</name>
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    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318563.1">
        <property type="nucleotide sequence ID" value="XM_011320261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RFX3"/>
    <dbReference type="EnsemblFungi" id="CEF74944">
        <property type="protein sequence ID" value="CEF74944"/>
        <property type="gene ID" value="FGRRES_02617"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02617"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06279"/>
    <dbReference type="eggNOG" id="ENOG502T4IX">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035151_1_1_1"/>
    <dbReference type="InParanoid" id="I1RFX3"/>
    <dbReference type="OrthoDB" id="4636359at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF74944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="459" mass="53334" checksum="CBC45F269E5E23F4" modified="2012-06-13" version="1">MNNKLHGPEQHNRQFADSKMAFDGSDPFTKLPPEIRLYVLTSIECTSTISRLIKASPTMLQQYLAFKKHIIRKVIGFDQDEMQDAMAIILFPGKRIRTKRQAAPVRVLLRNWSNRQLPDPIENKDDRLISRLNKLHKRIMLLVEDYITKATAFFLPREYLCLPQGRHSSEGHLMFKGVKVAPRFNSTNLATFERKRFVKAFLMHELVCKMKNIIDLPVGFRRRKVSNGDIETLNCVHAYYCSLYGAIFAQCSDAQLPSNPTGGSFESELQFPDTFYFDTNSHTHKVGLFSFNMFGGDPPDYSDGFSRLGLDHLADFLRYDMAQADDREALKVLIQDSTFDKQIYCWKTQLASIFHRTRRAEDSCDSAMYKQLSLDRDSELRYDIGRQRAWAFFDDSRLYPQDTIERPIFPSDSFLKKESIEKTFTDDWFRNPVRVRAWRQGKLSSEERIKTHLAKAGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I1RG24</accession>
    <name>I1RG24_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="4" type="primary">FG02673.1</name>
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    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318624.1">
        <property type="nucleotide sequence ID" value="XM_011320322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RG24"/>
    <dbReference type="EnsemblFungi" id="CEF75008">
        <property type="protein sequence ID" value="CEF75008"/>
        <property type="gene ID" value="FGRRES_02673_M"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02673"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06407"/>
    <dbReference type="HOGENOM" id="CLU_1906910_0_0_1"/>
    <dbReference type="InParanoid" id="I1RG24"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF75008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="133" mass="14254" checksum="93DB2FEB7A20148B" modified="2012-06-13" version="1">MKDYITITYSVTHRGHRPRPSPTTRPSTGDQASPPAQTLSPSTLQPPPRASLPRRSGDAPAATEGPTRQTSIYIPQGQSGSVETGRSSPVTGVSLEVREMLERSMSIRWDEGIGLAGCVWLMALVMVVVVVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1RGL5</accession>
    <accession>A0A098DF50</accession>
    <name>I1RGL5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG02886.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T11539</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322919.1">
        <property type="nucleotide sequence ID" value="XM_011324617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RGL5"/>
    <dbReference type="EnsemblFungi" id="CEF77573">
        <property type="protein sequence ID" value="CEF77573"/>
        <property type="gene ID" value="FGRRES_02886"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02886"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11539"/>
    <dbReference type="eggNOG" id="ENOG502QTQ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044876_1_1_1"/>
    <dbReference type="InParanoid" id="I1RGL5"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF8">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="18"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF77573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="337" mass="36787" checksum="9D9DABD23D5CF216" modified="2012-06-13" version="1">MPRYAKDQPEGFNNAIERVAIVGAAGTVGAYITAALLQTGKHIVTALTREDSTNKLPDGVIVAHVNYNDESSIVSALKNQQFLIITIAPTAPRDTHKKLVQAAAKASVPYIMPNGFTGDIEQAKLGEDTLLGPVGKANRDEIERLGMQWVNICCGFWYDYSLAGGEQRFGFNLDNRSVTFYDDGNTKNSTSTLSQVGRAVAKVLSLKELPVNEDDHSLTLSSFLNKPVNIKSFVVSQKDMFESIKRVTGTSDADWTITYESTKKRYEEGMGMVKSGNMAGFSKLLYARAFFPEDPSNLSAKAQNDLLGLPEENLDDATKAGIDLVKTLQGRAERMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1RGP3</accession>
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    <name>I1RGP3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
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    <gene>
        <name evidence="2" type="primary">FG02916.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T11611</name>
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    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322885.1">
        <property type="nucleotide sequence ID" value="XM_011324583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RGP3"/>
    <dbReference type="EnsemblFungi" id="CEF77609">
        <property type="protein sequence ID" value="CEF77609"/>
        <property type="gene ID" value="FGRRES_02916"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02916"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11611"/>
    <dbReference type="eggNOG" id="ENOG502SKQE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028906_4_1_1"/>
    <dbReference type="InParanoid" id="I1RGP3"/>
    <dbReference type="OrthoDB" id="5412996at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF77609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="376" mass="43264" checksum="03D15C4355A6D438" modified="2012-06-13" version="1">MEARQDSDKLAWDWIDALWEEAVKHVQLSSICRKIESFVKRTFGQTATLLLPMVIGGFNVLYPIKIEGRSGNVLVRMPCLNQAVFPVEKTLAEAATVAYVDQRTHLRAPRVFHHGVDSDIGPFMIIEDLGSRRGMGQALEAPRENLNNPAVLQPDISKAKLNSLYVEMASFKRSEIDISARRNDLLAKQGRLSSFGFAEDSCHQTAQALFASDWEFVYAAPTQFILDPPWWLLLDVPEMWGAGIEDWRKTYETRLDPWISAMQEAEQEVSPESFLFSTYMRESWTTGRFWLNYAARKSWAFDTIYWKYLDENFFGEREDGTPGEKMWKTKVHLLSGKERAAMERLAQAKMAESKTRVLIEWEAESAKKHLSRFLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I1RHL2</accession>
    <accession>A0A098DGG4</accession>
    <name>I1RHL2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG03271.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T12473</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322477.1">
        <property type="nucleotide sequence ID" value="XM_011324175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RHL2"/>
    <dbReference type="EnsemblFungi" id="CEF78039">
        <property type="protein sequence ID" value="CEF78039"/>
        <property type="gene ID" value="FGRRES_03271"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03271"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12473"/>
    <dbReference type="eggNOG" id="ENOG502RJBF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004835_4_1_1"/>
    <dbReference type="InParanoid" id="I1RHL2"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="201"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF78039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="604" mass="68604" checksum="77512EFF711BA110" modified="2012-06-13" version="1">MEHAIDESAEWPPRKRLRTSHAVDPGVKMQETNTIGHDCTYGSEANSNPGSRRSKNDLILESVLRVERTLHELRSTIPANIQLACQQHAINSPQINRTNSFSGSSPDLNLRRQSQAIQTPNSQDNRENVTNFENAVLDSMHTSTTESILQWPHFDVFPLLRHDGESIFYLEQSRKPLSVAANPMYPYVDTEDISSMLEAFERNINFWYPSMSQEQLSSIRETLQSGMPAEDTVHSCLCLLTLALGCASQAAEDLRFTTEAEPSEKDRRLRKRKLGDIYFQLALKKLHVVHLQVDSQSTQCLFFTALYFASLVRPLQAWEYLSATATRCMLLLSYPVNKNDNEAEERIRRIFWSCYILESDYMAELSACPPSGIARVESSVPLPSSYHTHTSEIVEEESSLYFLACISMRRLLNRVHQLLYARDTGAAFDHTRFPRIVAELQRQLDDWRDVLPASFSFSVDTDEVPTAAGGFLRQRYLTCKGVIYRPYLMWMLSSSYDDTGTSTSAVTPAIPDVMNKYLRGFSQTVVIDTWICSLSMSGAMLIILAASHIPALKEFIGTRATLVGSHLERLFRNWRDMSFGGDSPSVDRSMWLINQADSYIRDCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1RIE7</accession>
    <accession>A0A098DHK0</accession>
    <name>I1RIE7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG03579.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T13209</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322126.1">
        <property type="nucleotide sequence ID" value="XM_011323824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RIE7"/>
    <dbReference type="EnsemblFungi" id="CEF78408">
        <property type="protein sequence ID" value="CEF78408"/>
        <property type="gene ID" value="FGRRES_03579"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03579"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13209"/>
    <dbReference type="eggNOG" id="KOG1209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="InParanoid" id="I1RIE7"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010968446" evidence="5">
        <location>
            <begin position="17"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF78408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="306" mass="33390" checksum="582188BBB9F03B04" modified="2012-06-13" version="1">MSQLIWLVTATTSGLGAAVVQNLTTRGDRVVATGRGVTERLKHLQSDDVYLLDLDVTAPRAEIAEQVKEAWDVWGRIDVLLNNAGISAPKSVEEADDDFVRNIFDVNLFGTLHVAQAILPYFREQKSGTLAFIGAGVGWGPLPFLAHYAASKAALGAFVEGLAKEVRRFNVRCIIFEPGGFPSQLGQPREGSVEGFGKYKPAIDAYNPGFEEMMDVFANDIAPSVPGDIRKLSERIVDCVKVEGMSAGRDEPVRVILGSDALRLIEQKCKEQLELASTWEDVSLSTDRDGHNHVASKGMLRYSSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1RII9</accession>
    <accession>A0A098DKL0</accession>
    <name>I1RII9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG03626.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T13325</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322074.1">
        <property type="nucleotide sequence ID" value="XM_011323772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RII9"/>
    <dbReference type="EnsemblFungi" id="CEF78466">
        <property type="protein sequence ID" value="CEF78466"/>
        <property type="gene ID" value="FGRRES_03626"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03626"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13325"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_0_1"/>
    <dbReference type="InParanoid" id="I1RII9"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010968447" evidence="5">
        <location>
            <begin position="18"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="534"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="577"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF78466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="598" mass="63891" checksum="88481C61891CED0C" modified="2012-06-13" version="1">MLVKPQLWLAFAAAAVAAPSQDAYDYIVVGGGTAGVAVAARLSEGLPSSKILLIEAGPAALDEPKINVPGLKGTTLGTKYDWNFTTVPQTGANDRVWPINRGKVLGGSSALNLMTYDRASAAEYDSWEALGNPGWNWKTMIKAMMKSETFTGKNTATYGSKGVGDSGPVQAVVNRVIPKHQESWIPTLNKLGIRKNLESLGGDPLGVMYQPSSIDPANYKRSYSANAYDEISGSNLEIATDTTVTKINLSAPKGKKKAIATGVTLADGTIIKASREVILSAGSIQSPPLLEQSGIGSKSVLAAASIKQIIDLPGVGENLQDHLRIMSSYQLKPQFTSIDIFKSNATFAAEQMALWNAGKQSLYDYTGSAYTFSTWKQALGSNAKLLSLAKEAVAKDGSKVDKKKLDFFKDSSVPQVEVIFSDGYTGVKGYPAATSPLFGKGFVSLIAVVMHPLSRGSVHINPSDPAGKPIINPNYLSHAHDVEAVTQAVKYNRKIANTEPMRSIWDDEYEPGLDVKTDEQLKAYALRTTLSIFHPTGTCAMLPKNDGGVVDAKLKVYGTENLRVVDASIMPLLISAHIQTAVYGIAERAAEFIIAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1RIY1</accession>
    <accession>A0A098DJL0</accession>
    <name>I1RIY1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG03778.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T13685</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321909.1">
        <property type="nucleotide sequence ID" value="XM_011323607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RIY1"/>
    <dbReference type="EnsemblFungi" id="CEF78645">
        <property type="protein sequence ID" value="CEF78645"/>
        <property type="gene ID" value="FGRRES_03778"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03778"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13685"/>
    <dbReference type="eggNOG" id="KOG1303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027816_3_1_1"/>
    <dbReference type="InParanoid" id="I1RIY1"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF683">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="43"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF78645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="466" mass="49985" checksum="8672C20ED932D3F1" modified="2012-06-13" version="1">MSHYDSENQAAEPSKHHSGEDAAVTNDAVFGTITEDGPNYRNVGWLGTSVLMMKSQIGLGVLSIPASFDALGLIPGIICMLVIAVITTWSDLVVGRFKQRHPEVYGIDDAAGLVFGRVGKEFYGISYSLLTICIAGSAMLGISIALNSLSMHGTCTAVFVAVAMVVAFLTASIRTLDRVSWLAWVGLVTLVTSIFVVTVAVGVQERPDLAPKEGVWKSDYKLFNTPTFAEAMSAIAAFIFAYCGTPVFFPIAAEMREPKHYKKSLILCQTVVTVVYVVVGIVVYYYCGTYVASPALGSAGKTIKKVSYGLALPGLIVSATLYTHVPAKYAFVRILRGSKHLSANTFTHWAVWLSCTFGMAIIAYVIASGIPVFGGLVSLVGALLGTLQCMQLFGCLWLYDHWAEGKDKSQRTTRWTMMVGWCCFVIVLGTFLMIGGTYGAIKGIIDSYAVSGGSAAWSCADNSNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJ48</accession>
    <name>I1RJ48_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 2, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="7" type="primary">FG03849.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T13853</name>
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    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321833.1">
        <property type="nucleotide sequence ID" value="XM_011323531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJ48"/>
    <dbReference type="EnsemblFungi" id="CEF78729">
        <property type="protein sequence ID" value="CEF78729"/>
        <property type="gene ID" value="FGRRES_03849"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03849"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13853"/>
    <dbReference type="eggNOG" id="ENOG502SPG4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089692_1_0_1"/>
    <dbReference type="InParanoid" id="I1RJ48"/>
    <dbReference type="OrthoDB" id="8121437at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13695">
        <property type="entry name" value="Zn_ribbon_3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01328">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="3CxxC-type" evidence="5">
        <location>
            <begin position="53"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF78729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="190" mass="22220" checksum="03053246510EE9AA" modified="2012-06-13" version="1">MPRQRKRSKEGPLWVMYPDLHDQVADKLEEVQLDFTFNPNDDGLTSRKSYDTNIMGRFACNNQNCTTTGWSSKKIAITIRQYSQDRYNARVYHQRCRKCKSLGEPTLDEESYIDRVSYRIKKWNGVEMDIPKWGRDEFKGPHERAFCEGCKDGHCREGSNKAVPTRRVTNNRGLKEITQKHEDAPEPHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJ65</accession>
    <name>I1RJ65_GIBZE</name>
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        <submittedName>
            <fullName evidence="5">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG03869.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T13917</name>
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    <organism evidence="6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321805.1">
        <property type="nucleotide sequence ID" value="XM_011323503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJ65"/>
    <dbReference type="EnsemblFungi" id="CEF78761">
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
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        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
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        <property type="entry name" value="PROTEIN TSGA"/>
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        <property type="entry name" value="MFS_1"/>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
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            <end position="43"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="EMBL" id="CEF78761.1"/>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF78761"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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    <sequence length="457" mass="48487" checksum="7B2990C8F311CEC2" modified="2012-06-13" version="1">MAGGVPVAAPALAGGYLSGRALIFPLSLVISLFFLWGFSYGLLDVLNKHFQTVLGISRLESTGLQVMYFGGGYLLFSPIAAEVLKRRGYKQTILMGLSLYSLGAILFWPVAKSAETSTNSRAVFGGFCCTTLVIACGLATLETAANSYAVVIGNPASANARLQFCQSWNGVASFIGPLIASKFFFSGANQNSLTNVQFVYLAVSCAGAAVAVLFFFAKLPEISEAVIEDEAGHSNEGSIWKQYNMWFAFVAQFCYVGAQVTVATFFINYAHENGGVSTASASNMLSYALITFTVGRFVATGLAVFLRAEFIMVVYSCCAIALTAYCSAGSGAASIGVLIAIFFFEAPMYPTIFALGTANLGRHTRRAAGILVMGVSGGAVFPPIQGAIADAASTRISYIVPTVGFVYVLAYVTVCWVRGGMKILVEKTPESQVDEITGDEKNDVIVEQHEKKAGDMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJU5</accession>
    <name>I1RJU5_GIBZE</name>
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        <submittedName>
            <fullName evidence="5">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG04127.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T14553</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
    </comment>
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        <property type="protein sequence ID" value="CEF79079.1"/>
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        <property type="gene ID" value="FGRRES_04127"/>
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        <property type="entry name" value="HR1_rho-bd"/>
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        <property type="entry name" value="Rictor_IV"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF79079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1382" mass="153823" checksum="FD27D06C9BCD6EE3" modified="2012-06-13" version="1">MLSSSAAQKGMTPPSQSSQPSLPQQLSGRTSFDRGDSGLQPPNGANNRNLSASGVSFAPRGSSLNVAPGSFSSELRSRAGSKTEAGSVYPSSFMDKVEEADADTLAEQALANLRERLNREMKIKEGSENMLEALNSKKAKQTKEQRQKVEAELNASNLRIKDLRQKISDTQRTRQIPPDTPKRNRTQSNTIESTRPIGLRSPQSVSRSIGESDAEEPTESPTFALAELLQALEVEGMTPEYYVSRGNQLVDLFQRYPTLKYDLVWSVFGLRMQVMLLSESREVVAAGYRMTRYAISDVASLKKIRSLNTDYLVIRSLNNYRKADVEREQALKFVRAFLDVKGGVKEVSRSVVRTIVAVAEHGEDRRPNGQSVEGDIDRLRPICIETLAEIIVQDPALLVASGGLGPLTEALAEGVYKAPESLASAFLYLLDSPQTRKYIQPGYGLEVLFTVFTDHLLTNETVMKQNAKAIATALKSWPGLMTLCMYDLRTIRSFVTSMLLPSDVVRETILDLIFSLLRIKPPAWATSFLAGRRLTTYGRVANLRSSQKEKSQSQFMEEDSGEQNFVEHYTALLLAIFIRAGLLPILLKIAQGDENPTLQRKTTLLISEVLKLASRLLPPSWSAELHLLPELFSSAANIGNNDHWVASGIVYQISSVSRTLYRSTPSGALSGALSSGNHTTEMSAIDEAPKSHQSLVFDDATFRQLLIDSNVLNSSNYAKWNWETIIKIIDGPLQSGKRLEEAIKASKFMKRIISFYRPFKYRFANVKNTRGTQKYVRAGCALMHSLLQSPEGIKFLADSKLLRQIAECLAQCDPTSGLTAQYPMFSKDRVTDTLCAGYFSMVGVLSGDPKGLQLLERWRMFNMIYHIMDLKQRPDLIKLLLSSFDYSVQGHPRVLVSKALTAGTKEIRIHATNALRKYAIRPVPSANSQGGVGDSKWAIQLLVTQLYDPEIEVCATAVKILEQACNRKTYLEYIVECRPALDHLGEIGAPLLLRFLSTSIGYHYLDGLDYISNEMDDWFLGRNDTYVKVIEASLAKTFLIDGDEHNPRMSLFNDGEIDGEYHDSHVPPHFYRELTRTQEGCRLLSDKGHFEDFAATIRDHGMDTGDAEMLVKVKGCLWAVGNVGSMELGAPFLESNDVVEHIIEIAEHHEVMSLRGTAFFVLGLISRSTHGLEILSENGWDANTTPMGSSLGFCIPNNLSKLLSLTPWKQKAVTSITLPPGQRTAQEPPPPRVAKPPLEPSELPALMSDEDVNTRVLELIVDLGNMVLYKKAVTDLQKLRAHKPTAFRSTAFFKEVMAAMEWNHYRLGVRRMVIDLFDKNVMRQIVFDEEEDDDDDSSDESGEESGEGGNSSGDDRTERQRSISEPLAPPPELTPAPLRVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1RKF5</accession>
    <name>I1RKF5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG04357.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T15101</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321250.1">
        <property type="nucleotide sequence ID" value="XM_011322948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RKF5"/>
    <dbReference type="STRING" id="229533.I1RKF5"/>
    <dbReference type="EnsemblFungi" id="CEF79351">
        <property type="protein sequence ID" value="CEF79351"/>
        <property type="gene ID" value="FGRRES_04357"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04357"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15101"/>
    <dbReference type="eggNOG" id="ENOG502S7KB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019703_0_0_1"/>
    <dbReference type="InParanoid" id="I1RKF5"/>
    <dbReference type="OrthoDB" id="3539644at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="Toastrack_DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4097" evidence="3">
        <location>
            <begin position="301"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF79351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="696" mass="75209" checksum="677D28FE16466C52" modified="2012-06-13" version="1">MPAPYSDNLYSADSDGEPDALSPTDGYFHASSESSSSRSPHVPNVLVEDPTQLSRDDKAREAERERLLLNTGGSSGREERGESTASSHERQASAENPIGATPQPQPQPRSYSQRISTFAHSVDAPPAYSPSPTSPNTVNNYQTFTSVATMGRPEETQPLVAHSHVPESMSDPSPNPGQSPSRWENIRDFIARLNFRRKLKTFLASLLIFSVVFMIFSSFTLQSSHGPNQVKERGKFTWSPSRTCPEAAHRTGTVTKDINIQPSRDLSVVQTVKDIRGHEGWTTHISGEVILRPTDKSSPAKIEIEVLSNTDGLNVEVDIDETMQFIEVVVPRKMAHSTSKSTPCIQVRVNIWVPQGSVINNLTLNTAQFDVIIDPGVTLGALGGVNIWTASGDVTTPGLDGTSTGKDAAPYNLSSREIRIHTASGDVKGWYPLYDLLDIGTASGDVTTSIGPKPVNPQDVKSATFKVRSASGTITIDEPIAGAQKAPRPDREFPPRDYIVDIITASGDIKANVAASSSASFKSQSGDLQLQIRPVLDSSLMTGVTSLASPNLVTDTKSGNTSVKLLEPLWTNPATIGSTIPPLEPYDPKSGRDPYFILTEESETEASVSKPVFGLLQSKHKSISGNVKLSYPASWEGILYAQSMTGSQHYQGRDLKITREGGTFMNIIRGRKGTKGHSSLEVETVSGDQEAQIGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>I1RLC6</accession>
    <accession>A0A098DZT5</accession>
    <name>I1RLC6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG04717.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T16151</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323155.1">
        <property type="nucleotide sequence ID" value="XM_011324853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RLC6"/>
    <dbReference type="EnsemblFungi" id="CEF87355">
        <property type="protein sequence ID" value="CEF87355"/>
        <property type="gene ID" value="FGRRES_04717"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04717"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16151"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_0_3_1"/>
    <dbReference type="InParanoid" id="I1RLC6"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF87355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="509" mass="58403" checksum="5DD8CF876959BEF5" modified="2012-06-13" version="1">MSTYIDIVLENPQYAVLSTISLIAILIANYSFFAKDDKYPVLNPKKPFEWSNTRVVKEFTENSKSLLAHARSVYGEQPYRAYTDMGKVLVIPPSWVHALRSKKELDFRIPAQEDSHEYIPGFDGFGFHANMPTVITKYVTKSLAKMTGPISEETSLSIRDRLTDSKEWHSINPPKEMIRIVSRVSSRIFMGKELCRDEAWTKASSDYTVVAFASIALLRVYPRWLRPYIHWFLPYCKEARRLLKEARECLQPHLDRREVIKQQALAQGQPCPFDDAIEWFNNEYDKHDPATQQISISIVAYHTTSDLLCETLLNLCQHPELFKPVRDEIITVLRQEGGITKAALYNMKLLDSVIKESQRLRPILLGAFRRKAMADVTLPNGDVLRKGDRVIGETTHMWGPESYDNALEFDPYRYVRMRESGEENKAHLVSTSPEHLGFGHGVHACPGRFLAANEIKILLCHLLLKYDWKLPEGAEPKPSFASFRIDGDKTTNLLIRRRTEELDIDSLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1RLW2</accession>
    <accession>A0A098DZS0</accession>
    <name>I1RLW2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG04932.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T16667</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323403.1">
        <property type="nucleotide sequence ID" value="XM_011325101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RLW2"/>
    <dbReference type="EnsemblFungi" id="CEF87351">
        <property type="protein sequence ID" value="CEF87351"/>
        <property type="gene ID" value="FGRRES_04932"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04932"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16667"/>
    <dbReference type="eggNOG" id="ENOG502TKA5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074861_0_0_1"/>
    <dbReference type="InParanoid" id="I1RLW2"/>
    <dbReference type="OrthoDB" id="5008122at2759"/>
    <dbReference type="PHI-base" id="PHI:1370"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF87351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="394" mass="43852" checksum="32BAB80F6DCB3B68" modified="2012-06-13" version="1">MAMINPTPLACSLSRARGFLAGLIFINSLPKIAGQDFNANIRLFQNTKQWTVLQHVHRQLEETRLRLVEVKRTISLECPDKTLASFNNPTSFYEAAISSFHNTLLGLPPTTLGGVVALCAMSHATSCYLYSTGIQVAFDPFSDFDLWRSTISNDEHQQAFDDLMMAACQEPYLTTLMNPFPIFQDEINLPSEDLNLLWSPDPITNTLIPFLITHNAAGESQAPDLQSLQGSPIVANLTHFLEQCGELPLILCGRDATADMCYFIGAPISTESGDEQDLKHLYIQLLRERGPLHGPVTQGIVSIVERFVDLGYLQSVDEVPDYMLLIGKEILPSNKTFLELCKSAWATLAEAKRRLHNIPCGKCGKVFTRPGNMKRHMERKARCAPLICNTLGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1RM66</accession>
    <name>I1RM66_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG05048.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T16963</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF85941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323531.1">
        <property type="nucleotide sequence ID" value="XM_011325229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RM66"/>
    <dbReference type="SMR" id="I1RM66"/>
    <dbReference type="STRING" id="229533.I1RM66"/>
    <dbReference type="EnsemblFungi" id="CEF85941">
        <property type="protein sequence ID" value="CEF85941"/>
        <property type="gene ID" value="FGRRES_05048"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05048"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16963"/>
    <dbReference type="eggNOG" id="ENOG502QWNS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_0_2_1"/>
    <dbReference type="InParanoid" id="I1RM66"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF52">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF85941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="312" mass="32653" checksum="479750F5DEC5172C" modified="2012-06-13" version="1">MGSPKASQLRLGDGVYVPTLAFFTPEDEVDGPALEKHIVKLLEAGVAGIVVHGSNGECAHLSPSERTTIIRVARDTIIHEASGTRVPLIAGCGAQSTRETTELCEDAGKAGATHALVLPPSYYGGLLPDDLIIQHFYAVADKSPIPILVYNFPGAAAGRDLSSDTILSIAKHPNVVGVKLTCGNTGKLTRIVADCPEGFFVGGGSADFILQGHAVGGNGTISGLANLCPRACVRITELANEGNWMEARQLQAKVAKADWMAIKTGFVGVKAALGHFGGYGGEPRRPCVAPSQKELDTIALGFQEVMDLETTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1RMC6</accession>
    <name>I1RMC6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG05115.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T17135</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323612.1">
        <property type="nucleotide sequence ID" value="XM_011325310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RMC6"/>
    <dbReference type="EnsemblFungi" id="CEF86978">
        <property type="protein sequence ID" value="CEF86978"/>
        <property type="gene ID" value="FGRRES_05115"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05115"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17135"/>
    <dbReference type="eggNOG" id="ENOG502RJ3U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_779799_0_0_1"/>
    <dbReference type="InParanoid" id="I1RMC6"/>
    <dbReference type="OrthoDB" id="5213862at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF86978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="445" mass="50342" checksum="2FC1B3579C1B6E97" modified="2012-06-13" version="1">MTNLGYEVPFWADLDACERAVVNEKPSPLRVTRYNENLQQDIRYAENRYNHNSMKYSQSFQGDGSLTIPKRRNVEAQTIAAGKENVRTPQYNQTLSTPSSRNMYTPGYWAQCNSPPRLLGVTPSPQLSVKKKRQAHTHVRMQPERNRSLSPFSINTLPAAYEMRRPGKARPPLTNLYDRDYMHKEESLLVSNATGWIGYPLPPDNNQQLPPINRLTTLPRQKTVPCVAPNINITPEVTAIEAGCNIFWVAIEVSATPWCAPETKSQPGARWERSDLFMNLAGLTQKDLEFDNRSESSGLHNLNVQILPTEQSSIIRILQEQPFPLDRLESGSSIFLLVKVRAHAAKDMQKERRECPQQEIDNLIEALEQELGDSTISYMTVKLSYRLSAFPEWQDVGSASDGMFSTHSKIETVVTASVKLHNAMSLWSPPPALKPNPLLPLIQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I1RNK8</accession>
    <accession>A0A098E2M6</accession>
    <name>I1RNK8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG05591.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T18281</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324147.1">
        <property type="nucleotide sequence ID" value="XM_011325845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RNK8"/>
    <dbReference type="FunCoup" id="I1RNK8">
        <property type="interactions" value="676"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RNK8"/>
    <dbReference type="EnsemblFungi" id="CEF88365">
        <property type="protein sequence ID" value="CEF88365"/>
        <property type="gene ID" value="FGRRES_05591"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05591"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18281"/>
    <dbReference type="eggNOG" id="KOG2126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004298_1_0_1"/>
    <dbReference type="InParanoid" id="I1RNK8"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="635"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="689"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="733"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="767"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="806"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="842"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="868"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="903"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="952"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="987"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1027"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF88365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1064" mass="117828" checksum="2174A5BE94DEEB5F" modified="2012-06-13" version="1">MAPKPKAKPKAQQQTPQTEHQKIAEQWAKAERARAAQQTANARFGLPPADENVEVLEQRREALDQRRRKTNEKSWRWAAGFWVVVLAIHALGIWLFTGGFLLTRLVLEDKSNCTIPPIENTKGLLNVDRGCWHPKSFDRAVVVLIDALRYDFTVPEDPAQAQHFHNAFPYLYETAVKSPQNAFLRPFIADPPTATMQRLKGLTTGTLPTFVDVGSSFGGSAIDEDNLLMQLKDAGKKIAHIGDDTWWSLFPGYFEPNISKAYDSFNVWDLHTVDNGVIDNIFPLLKPERKGDWDLLIGHCLGVDHAGHRYGPDHPAMGAKLRQMDDFIRKMVESIDDKTLLVVMGDHGMDSKGDHGGESDDEVEAALWMYSKKPFFGRTSRDFAVPPANAKIRPVNQIDLVPTLALLLGIPIPFNNLGGPIEEAFAGVKGNDWRNLAAVSRVASAGIERYQAAYHKARGLVQAEGIESPVALWQAALAIAKNDRDAHVAFSKFQECTLSVCKDLWARFDVPRMVMGIVVFGFGLVLLMMYSSRDEEDEYVIMNDAELDYAEKKLELLSFKENDPEIEDNFHKNVLKGLWDPKILFTVSVLTAVGMYRQHPIEGLVALVAVLFMAGLSSSLHEAGKTILNVFPSSFWVWMAVVFTVSQSIGFASNSYTIWEDSILLFFITTFGIASAVSAFRIESRRERYLGIYHSVAFVVLGRIASYSKLCREEQMPYCTSTYYASSTSSTSATWQLLIPFVVCLVLPAIIKSFLVTSRSYEGIAPTWIGLAIRGGLFLSALYWVIDAADNGGWLEGRLGDGALKTVGVYLAQTVLALAFVAGSTVFVWAPPCVSILQSSGAAGRPIVTIIGYGNAVGARYLLLPLNILLGCFLLTKPMGGGALAIMFWQILTLAELLDLNELKTSPIGPVMLAILGNFYYFKTGHQAVLSSIQWDSAFIPLFTIRYPWTPIVVVLNSFAGQIIAAASVPLLALWKVGPKQKGVMETATRSIGVFVIFYAVEALATMSWAGWLRRHLMLYRVFSPRFMLSSTVLLVLDLVIILVTMTGLRSNMMSLGEVFGWAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQ42</accession>
    <name>I1RQ42_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG06178.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T19685</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CEF87563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="229533.I1RQ42"/>
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        <property type="protein sequence ID" value="CEF87563"/>
        <property type="gene ID" value="FGRRES_06178"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:transcription coregulator activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
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        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
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        <property type="entry name" value="Mediator hinge subcomplex-like"/>
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    </dbReference>
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    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
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            <begin position="91"/>
            <end position="125"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQW5</accession>
    <name>I1RQW5_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
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        <name evidence="4" type="primary">FG06466.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T22341</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_011327764.1"/>
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    <dbReference type="OrthoDB" id="5313668at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048955">
        <property type="entry name" value="Cip1-like_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21340">
        <property type="entry name" value="Polysacc_lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124469" evidence="1">
        <location>
            <begin position="19"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Cip1-like core" evidence="2">
        <location>
            <begin position="23"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF84376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="239" mass="25993" checksum="3E9EEE68B708F3AA" modified="2012-06-13" version="1">MLRQIALTALSVLPLTLGQVAEDFESGWDQVAWPTYAPDCDQGGKVVLDKTTGHSGTNSIKVTGGPNGFCGHKFFGTDAIPSGDVYVRAWMKSEKTLDDSHVTFITMPDAAQGKGKHLRIGGQSKILMYNHESDDATLPDLSPEGIAASKNIPANQWQCLEYHLSPDGTIATWLNDSPVKGLVYKPNDPASYSNGWKNSKPKPKIQGVYFGWESYSGASNTFWYDDIAVSSKRIGCSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1RR06</accession>
    <name>I1RR06_GIBZE</name>
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        <submittedName>
            <fullName evidence="10">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG06508.1</name>
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    <organism evidence="11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF82803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_011327816.1"/>
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    <dbReference type="AlphaFoldDB" id="I1RR06"/>
    <dbReference type="FunCoup" id="I1RR06">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF82803">
        <property type="protein sequence ID" value="CEF82803"/>
        <property type="gene ID" value="FGRRES_06508"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06508"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22469"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="InParanoid" id="I1RR06"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AA-permease/SLC12A_dom"/>
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    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
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    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="42"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF82803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF82803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="515" mass="56324" checksum="7551940C9B7F87E0" modified="2012-06-13" version="1">MFDSSSADEKSPRVSNDKKPKTDKEDVETGEAGLDRAMSSRHLQFIAIGGTIGTGLFLGVGPALVKAGPVSLLVAFAFMGSVVYSVMVSLGEMAAYIPITGSFTSYAARFVDPTLGFAMGWLYWFSWSITFALELVAAGIIIQYWDSELSIAIWISVFWALFTALNFVPVRIFGEIEMWFSMIKVVTIIGFIIFSICINAGVGDEGYIGFKYWNDPGVANTYMGIEGATGKFVGFWAVLVTAGFSFQGTELVGVGAGETANPRKAIPEAIRWTFWGIFSLFMATVFFVGINVPFNDPALDSGAQDASASPLVVVATRAGVKVLPDIINAVLLSAILTAANSNVYSSSRIMVALAEDGLAPAFMKRTNKYGTPYFAVASCSVMGLIAYINLSSSGEKVFNWLLNVSSTSCFITWVLINVCHIRFQKIMKAQNIPREELPYLAPLQPYLSYYGAFFVALITITCGFTVFIEWNTADFFSNYISLMLFFVLYVGHKLICRTKVVPLMEVDLSKGREEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1RR38</accession>
    <accession>A0A098DU62</accession>
    <name>I1RR38_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG06547.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T22557</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326158.1">
        <property type="nucleotide sequence ID" value="XM_011327856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RR38"/>
    <dbReference type="EnsemblFungi" id="CEF84363">
        <property type="protein sequence ID" value="CEF84363"/>
        <property type="gene ID" value="FGRRES_06547"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06547"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22557"/>
    <dbReference type="eggNOG" id="ENOG502SHMS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051533_0_0_1"/>
    <dbReference type="InParanoid" id="I1RR38"/>
    <dbReference type="OrthoDB" id="3204049at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF84363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="487" mass="57287" checksum="81F57F57821AB7FE" modified="2012-06-13" version="1">MAHQAERLPWQALVSIFDLKPTNPCQHDAPNLHPRDEPETRQKLSQFLDAFIKNASLDAQRERKKYPEKYDPLDAGIFLKSMTGEDEDEGPRTQYDDPPKEHVILTDELVDKIAPTVKRWYPKNKDGSISSKFYQGLQCPHTNDSDKCECVLPRKERQLAAFQRDYYPNDCFEFYGHNGEAYRNLEFVKTLILLGEMDPVLQVCSTDECYLAKWWNAGPCYCEDFTLGWDMICNYAIKMYLTLNILYCFPETWQTEDGSPVDNYRGLASYQMAIRLCTLSSECQVATYPHRDVFGIQDKQFDIYPKPFDLRRWKQYIKVDDSFVSQMREMNPDWDMGPEFVDRSTYKLKFYPYGLITYDEFLNFEKPVSYQPHTNDVSHVRWMLGQKGLPTELVDSIISKAEYSPGRSLPVDGRPFHPGNKDELGRYLEECWQLIVRCFMLGRELENEDVDFEKRIRRLFKVCIREVFRCDCDGNVELFYNFDGQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I1RRI3</accession>
    <name>I1RRI3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG06706.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T22963</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326342.1">
        <property type="nucleotide sequence ID" value="XM_011328040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RRI3"/>
    <dbReference type="STRING" id="229533.I1RRI3"/>
    <dbReference type="EnsemblFungi" id="CEF84281">
        <property type="protein sequence ID" value="CEF84281"/>
        <property type="gene ID" value="FGRRES_06706"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06706"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22963"/>
    <dbReference type="eggNOG" id="KOG0116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022209_2_0_1"/>
    <dbReference type="InParanoid" id="I1RRI3"/>
    <dbReference type="OrthoDB" id="339151at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990861">
        <property type="term" value="C:Ubp3-Bre5 deubiquitination complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000003">
        <property type="entry name" value="Nuclear transport factor 2 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF20">
        <property type="entry name" value="AT27578P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="48"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="405"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="480"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="343"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="484"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF84281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="538" mass="56491" checksum="BAAB956F162813F7" modified="2012-06-13" version="1">MASNGNFAQQDQYKEPADQQQTAPATSAADGSTTAAASANSNLSKDEVGWYFVEQYYTTLSKSPEKLHLFYGKRSQFVYGREAELSTVSVGRQLIQERIKELDFQDCKVRVSNVDSQASFENIVIQVIGETSNKGAEPRKFVQTFVLAQQPSGYFVLNDILRYIDEETEAEATTATEEAPEKAAEEIAVPATEEAAPPAEPEAPQSVEETQEEAPAQPLDPEVVDHKLEEVSTDKDSVTLNGSAAETSADEVKAPEVKPEAPAETADQAAKELAEEDVKEAEKPKDPSPTPVSKPVAAPPAAPEKPAGPPKPMTWASRAAAALPRPVVPLSKTPTPPVNQSRAPAPAAAAPTSQPAAAPASTANAPAAEAAPKEAAGWQTAGSDSKRQNRPQSVSGPPPTEKEGTLGYVKYVTDKVQDADLKNALAAFGELTYFDINRQKNCAFVEYKTPEGYQAAAAANPHTVNGESIVVEARRPKANAYGGTSYGGGRGPAPGRGRGGAEGGRSGGQGSRGNFSGQNRGRGGAARGRGAAAQPQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>I1RS64</accession>
    <accession>A0A098DUQ9</accession>
    <name>I1RS64_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG06977.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T23657</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326656.1">
        <property type="nucleotide sequence ID" value="XM_011328354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RS64"/>
    <dbReference type="STRING" id="229533.I1RS64"/>
    <dbReference type="EnsemblFungi" id="CEF85089">
        <property type="protein sequence ID" value="CEF85089"/>
        <property type="gene ID" value="FGRRES_06977"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06977"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23657"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012050_0_0_1"/>
    <dbReference type="InParanoid" id="I1RS64"/>
    <dbReference type="OrthoDB" id="426001at2759"/>
    <dbReference type="PHI-base" id="PHI:5743"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14521">
        <property type="entry name" value="DSP_fungal_SDP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="336"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="439"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="516"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="743"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="568"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="585"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="633"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF85089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="795" mass="86729" checksum="602D2122236A5FE9" modified="2012-06-13" version="1">MPSVTDRRVYEDQIPPFMTVFDLDAETMADQDTVTLMDTKFVDIDSKRPGMMATSHQHGLAPSMMPVDSIHKHHDSTSTQTSESADSSPTTTLSTTDSSPLSDASPSSSPDSPMNLIPLNNFPATSFGTLGVNNMSMNYNANSSTMLSEPPRLQRPMTSPSPRRGRNMKGLSIQPPFAVSTATTNISLISEPASPSFIKPTIPAMRRKPSQLSLNTNTSDLNHKTTLEVPPSPAMPMLQRRALKHSCSSPHMSSGLKSATFGPPGGMTFPKVLERNESGLSEVLRPSKSTLKPTTIHSAITEEDSPIRTQMAFRDDDPYRDNENNEDMKTPGYPDGPIAIYGDNIFLYSEPTAEEAARFDVVINCAREVSNPFEINKATRRPMSIAEPDTAVSTASFMTAWEFPQGDDSAETPTTPKALQFQEPEYIHIPWDHNTDIAPDLMDLCHVVDDRTKAGKRVLIHCQQGASRSASLIIAYGLFQRPELTVNDAYYAAQAKSQWISPNMKLMYSLQDFQKEVSTKRTAQPSNRPRPGRKPSKHRLTLSANAIDIGPKEPQTAPLPTQGEDVQDSNLSSSPTRLRGNSTPGPRPVSPGPASAPPTCTWKDEIEQRPSDKLNPFKLGDLPKRPVSNHGNAPPTLAPPTLVLPTLAPSTLAPSPMMDSSMKPPPSPGFPSQSSFGFQSMTFPRFNPAPPEMKFNDSPFQRTIALPGSYPEDDALLSPRAETMTNNPLHDVPEVAGMRFVESPPTPGQGLFSPRAGMFPRDPFSTFGRPPVVADPRSPPTKGEAPIIRSIDDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1RSN9</accession>
    <name>I1RSN9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG07167.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T24125</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326885.1">
        <property type="nucleotide sequence ID" value="XM_011328583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RSN9"/>
    <dbReference type="EnsemblFungi" id="CEF85337">
        <property type="protein sequence ID" value="CEF85337"/>
        <property type="gene ID" value="FGRRES_07167"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07167"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24125"/>
    <dbReference type="eggNOG" id="ENOG502QTNX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023475_0_0_1"/>
    <dbReference type="InParanoid" id="I1RSN9"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="187"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF85337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="458" mass="50858" checksum="4E4A1CDDFA5E6C40" modified="2012-06-13" version="1">MSNSQAPSSLATLLWDHQNFIPLQKNLGEEDLVLLLTPAVIPLDQSLASATDPFQPLGQALSQTHPWIRHVPYTKKYGITGTHVAFVKKVRIVVFVLSGLSSDEGSFQLELADIVREVCDERPFALVACCEVPKSRVEEYEFQTVVQCSGYMVSDLQAVAALLTTEQTTTAAEPTIDDSPPPQTWPLVKWDYNEDLPETYALWEASFPAKFHLHRSTFSSLLKRDGYAMHYIIREPRSGRAVAFCATFTTFTDSSADRLIGSIAAIIVHKDYRGRGIGRRLHNEVMSKLNKIRGVGIIQLGSTFPRLLYGLPASVTNTEWFEKRGWKLHESIPGHGRLVIDWLLRFADSPVPDLASAGLTFRPCQLSDYQQIIDIATKESQRRYGFGWYDQYAKTMDSSYTNSIVVGLEGDNLVAAAITYLPNDGSPCGTDIPWPAAIEQNIGGVSCICIKGKLLGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I1RVM3</accession>
    <accession>A0A098DCC8</accession>
    <name>I1RVM3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG08305.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T09613</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320486.1">
        <property type="nucleotide sequence ID" value="XM_011322184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RVM3"/>
    <dbReference type="EnsemblFungi" id="CEF76609">
        <property type="protein sequence ID" value="CEF76609"/>
        <property type="gene ID" value="FGRRES_08305"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08305"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09613"/>
    <dbReference type="HOGENOM" id="CLU_1627188_0_0_1"/>
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        <property type="component" value="Chromosome 2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="163" mass="17731" checksum="9457220DBC2E40CE" modified="2012-06-13" version="1">MQSLKGRRDRASAIPMSKRPAKLARDGPRQMGSTEDAELEFGEGCNWKWKNGTKLRLTGRLSVSGKKELREPMGAGNDPIREWSPVQGLTSVASASALQPSSPSTEPNARSVMSVSISIFVWPPPFRAEKLSRAGRSTGSSVKSSRVAWHHVLSVHLNIAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1RWZ4</accession>
    <name>I1RWZ4_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="4" type="primary">FG08834.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T10945</name>
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    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319880.1">
        <property type="nucleotide sequence ID" value="XM_011321578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RWZ4"/>
    <dbReference type="STRING" id="229533.I1RWZ4"/>
    <dbReference type="EnsemblFungi" id="CEF77275">
        <property type="protein sequence ID" value="CEF77275"/>
        <property type="gene ID" value="FGRRES_08834"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08834"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10945"/>
    <dbReference type="eggNOG" id="ENOG502S73V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080664_2_1_1"/>
    <dbReference type="InParanoid" id="I1RWZ4"/>
    <dbReference type="OrthoDB" id="1601230at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044662">
        <property type="entry name" value="HS1/DABB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF77275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="110" mass="12102" checksum="387FDA4275B325E7" modified="2012-06-13" version="1">MTLTHTVLFQFKSDVDLSEIKEICDSFLALKDQCIHPTSNSPYIVSLVGGKDNSPEGMQNGLTHGFVAIFNSAEDRDYYVKSDPAHQVFIAKVGSVLEKATVIDFTDGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RX45</accession>
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        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
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    <gene>
        <name evidence="3" type="primary">FG08894.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T11105</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319813.1">
        <property type="nucleotide sequence ID" value="XM_011321511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RX45"/>
    <dbReference type="EnsemblFungi" id="CEF77355">
        <property type="protein sequence ID" value="CEF77355"/>
        <property type="gene ID" value="FGRRES_08894"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08894"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11105"/>
    <dbReference type="eggNOG" id="ENOG502RPY5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1170684_0_0_1"/>
    <dbReference type="InParanoid" id="I1RX45"/>
    <dbReference type="OrthoDB" id="5049336at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="241" mass="25863" checksum="0AEB51158CC0BF40" modified="2012-06-13" version="1">MASQSQPQTGTRLPPQSGPSMPTTATKQDIEALLAGPVLDHLAPISGGRWKLVSQQSNNIVVAYRVNGHEVFTTNVEMGANPDTVNDTCWQFVYGYPSGMPPLPDSVLQQWTPPVTNVRIPPQDFGSMSQIYNQILDANEIMATGAAPSRQGDTFPAPADVQLPEADDFSISMLDQAQTQVHDDALISGIESSQNTQSTNMAGFEPDDYTAFQNMGDLAHGGPNPFMFPDGTGDETDASPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RXC7</accession>
    <accession>A0A098DQL7</accession>
    <name>I1RXC7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG08992.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T28173</name>
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    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328812.1">
        <property type="nucleotide sequence ID" value="XM_011330510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RXC7"/>
    <dbReference type="EnsemblFungi" id="CEF83627">
        <property type="protein sequence ID" value="CEF83627"/>
        <property type="gene ID" value="FGRRES_08992"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08992"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G28173"/>
    <dbReference type="eggNOG" id="KOG1210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_8_2_1"/>
    <dbReference type="InParanoid" id="I1RXC7"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF83627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="283" mass="30950" checksum="EC58E8F6832B8369" modified="2012-06-13" version="1">MLSPIHKTTYPAISPLRPELSTKGKNALITGGGSGIGASIAKSFAKSGVTNLALLGRTGKTLLANKAEIEDKHPQTKVWTYIVDISDSDSTRYALEAYAKAVNGKIDILIANTGYMPKAERITVADPDDWWSGFEINTKGNFNLLRAFDPLAAPGARVIHVSSRSTYIEYLEGFSGYRASKLAAYKLFSWYANENPDKVVHQFDPGFIFDTGMTAPFEGLIKEKGLVGDDVELPSDFSVWLASNEANFLSGRFVECAWDVGDLKAAKEDLKASWNKWTIGLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1RYB1</accession>
    <name>I1RYB1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG09353.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T27287</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
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        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328393.1">
        <property type="nucleotide sequence ID" value="XM_011330091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RYB1"/>
    <dbReference type="STRING" id="229533.I1RYB1"/>
    <dbReference type="EnsemblFungi" id="CEF84274">
        <property type="protein sequence ID" value="CEF84274"/>
        <property type="gene ID" value="FGRRES_09353"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09353"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27287"/>
    <dbReference type="eggNOG" id="ENOG502SJ8E">
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    <dbReference type="HOGENOM" id="CLU_047729_1_1_1"/>
    <dbReference type="InParanoid" id="I1RYB1"/>
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    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
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    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
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    <dbReference type="PANTHER" id="PTHR34618:SF3">
        <property type="entry name" value="GEGH 16 PROTEIN"/>
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        </location>
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        </location>
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        </location>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="388"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF84274.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF84274"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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    </evidence>
    <sequence length="404" mass="40831" checksum="27DE0B4F08FB0525" modified="2012-06-13" version="1">MHSFNILLSSSLFALTQAHSVILGAQGLDSSPNSVGFQVDPEIARNCITINPCQQDATIIRDAEITANIVNQCGRTEISGNIDVGENTENAIAAKQVTQVEAGGELTVTIHQVNADGAGPYVCDLDESSNTNTNIQNLTVTNNIPGTNGLSQAKTQAFNITVKMPDDLNCFGASTGNICTVRCRNNALAGPFGGCFAVQQADTDKKTNTPQNIKTTQTLNGINAQILQNQKDFEDSVAANENATSDEAAQNKAAVDALLGATVVTSAFATETPTVDLGRPPVATPDPNEGKDGQAGDNNGGNNGGNNGGNNGGNNGGNNGGNGGNNGGNNGGNGGNGGQGNNGQGGQGNNQGGNGGNGGNRGGNRGGNGGNPFGGNGGNPFAGGNGQKAKRGFSIRRMSKRTVF</sequence>
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    <accession>I1RYL1</accession>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328258.1">
        <property type="nucleotide sequence ID" value="XM_011329956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RYL1"/>
    <dbReference type="EnsemblFungi" id="CEF85524">
        <property type="protein sequence ID" value="CEF85524"/>
        <property type="gene ID" value="FGRRES_09467"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09467"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27015"/>
    <dbReference type="eggNOG" id="ENOG502T5PD">
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    <dbReference type="HOGENOM" id="CLU_1496333_0_0_1"/>
    <dbReference type="InParanoid" id="I1RYL1"/>
    <dbReference type="OrthoDB" id="5103494at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF85524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="180" mass="20282" checksum="FCA326B26E25243B" modified="2012-06-13" version="1">MTRAQGGTVYHCPSIPSLFVTANTSQHCHLYVTPPSRNQLSGGRQQLRQRRAGQPVYFGLSINYDTNVVHWDWRDAKNAGISPGYVTLDPEYDSISIRTQAMLRYDSVERNRIRTYNCSVLTICAQKTIIKWARAGTFQGPVISDVDRPLGLLELRLAGPIGAAEARRMLLVTEQYRLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZ16</accession>
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        <name evidence="3" type="primary">FG09634.1</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF82999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328074.1">
        <property type="nucleotide sequence ID" value="XM_011329772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZ16"/>
    <dbReference type="STRING" id="229533.I1RZ16"/>
    <dbReference type="EnsemblFungi" id="CEF82999">
        <property type="protein sequence ID" value="CEF82999"/>
        <property type="gene ID" value="FGRRES_09634"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09634"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26625"/>
    <dbReference type="eggNOG" id="KOG3734">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018502_0_0_1"/>
    <dbReference type="InParanoid" id="I1RZ16"/>
    <dbReference type="OrthoDB" id="3898179at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd07040">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF27">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF82999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF82999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="702" mass="75400" checksum="D97BCA1ECF47A2B7" modified="2012-06-13" version="1">MGRTPAYIFVVRHGNRLDAADKKWHLSSPTPYDPPLTYGGWLQARAVGNQISSILEQSKAEYESNSKDTKRRRRFKVVIHSSPFLRCAQTSIGISSGLAQTPHESPHRPNDIFVSATGPPKHFRSTILRLDSFLGEWLSPEYFEHITPPPGAALMLGSAKAELLRREDYSALTSASAPTPMPHRGSTASLWNGSPAASPSLGPMRPGSSAEGSSGPAMAAALTGQLASQLTKKGYTVPKPNYAISSSGKIPDGFVAHARDECVVVDYQWDSMRAPLDFGDGGQLGEEWTDMHKRFRRGLKKMVDWYATTDVPDEMVTQAAGTSQAGNDDNETASEDEDVETVVILVSHGAGCNALIGAITHQPVLMDVGIASITMAERKQDADYHALLAASAYEKEPHVSPHQMYDIRMSASTEHLRSTTSTPVSARSNAADSFPTTIRGRKPSISDEEGPGPLIGSFVYSDPIVPGGSRSASASAAFGSSMRRTSGSQRPLNRVPRLSTAAAPATTENNTAKGETTPKSNSPSTGTPSFGLWTPRSSSLRLMDDGSDDASDKEDFDTVLPNFGRFDNTTQSKKDGPLTSTTEVASSLPVQSSLPSRFELKSTNSLTMTLPPAAFSSLTSFSFPSSGETTPKATPRGPILSGPIRIMTDVLHDRDNPVEELPIGQLGDGLGGLWGLPRPPGEAERYRDVSLSKRRWTTTERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZF6</accession>
    <name>I1RZF6_GIBZE</name>
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        <submittedName>
            <fullName evidence="13">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG09795.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T26257</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327895.1">
        <property type="nucleotide sequence ID" value="XM_011329593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZF6"/>
    <dbReference type="FunCoup" id="I1RZF6">
        <property type="interactions" value="1440"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RZF6"/>
    <dbReference type="EnsemblFungi" id="CEF84414">
        <property type="protein sequence ID" value="CEF84414"/>
        <property type="gene ID" value="FGRRES_09795"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09795"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26257"/>
    <dbReference type="eggNOG" id="KOG1951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002486_0_0_1"/>
    <dbReference type="InParanoid" id="I1RZF6"/>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000232">
        <property type="term" value="P:regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="12">
        <location>
            <begin position="66"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="397"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="546"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="617"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1093"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="425"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="468"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="489"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="554"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="572"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="625"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1094"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF84414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1144" mass="130621" checksum="7F8AEAF8CD6BC888" modified="2012-06-13" version="1">MEDQVHKPHRKSKDRKEKKQNTGERNPKAFSFANPGKLQRQAARSQDIKEKRLHVPLVDRLPDEAPPRLVTIVGPPGVGKTTLMKSLIRRYAKETISDPQGPVTVVTSKKQRLTFVECPNELEAMVDIAKVADIVLLMIDGNFGFEMETMEFLNTLAATGMPGNVFGILTHLDLFRKPQALKDAKKRLKRRLWTELYQGAHLFYLSGVMNGRYPDREIHNLSRFLSVMKNPRPLIWRNSHPYSIIDSFRDITHPTKIEEDPNCDRSIVLSGYLRGTNFASQDQRVHVPGLGDFTVSNMEVMPDPCPTPNMETAMAKIAGKTGRRRLDEKEKKLHAPMSDRSGLKIDGDAIWITSDKGFSFDREEDEADRGEGEEMIVGLQAERKLLGQMEGGVQLFKGGEKVEAIPEEEDTGRKTHRKARFAQQEEGDEQNDENNEDLASDEDDVDSDAEVEFNEGKLGKMFRKDADKDLDEDDLAFADSDSDLGSMSGDEEVEDDEEYDSDEEAAALRWKDNLNGTAMKLHGKRRSYHTSDLARFIYDESLSPEDALKRWKGDDDESDEENIEDDEDDDDFFKKSKQEQEDSVEDRAIPAYDYEDLAAKWASEKNVEALRRKFTSTALAAGDDKDGEGDGSDFEGLDDEDDEGDGEFEDLEAEGQEQPAQPAQPMPEDIEAEREKNAKRKEELKMRFEEEDREGFLNDKANARRDGGDIQEFGEDDWYEAQKAMIQKQLDINKEEFENLDERQRSVVEGYRAGKYAKIVLEGVPAEFVKLFDARRPIVVGGLSATEDRFGYLQVRIKRHRWHKRILKTNDPLIFSLGWRRFQTMPIYSTTDSRTRNRMLKYTPEHMHCFATIYGPLIAPNTGFVCFNSMSGSMPGFRIAATGTILSVDESTEIVKKLKLTGTPAKIYKNTAFIKDMFNTSLEIAKFEGASIKTVSGIRGQIKRALSKPEGQFRATFEDKILLSDIVFLRAWYPIKPHRFYNPVTNLIGWQPMRLTGEVRRDQNVPTPQPKNSQYRQIERQTRHFNPLRVPRALAAELPFKSQIIETKKQKKETYMKKRAVVMAPGSEEKKARALMQQLLTIRNDAAAKRRAAKDKNRAAFQKKLAENEEKKEAREKRESKDFWRKNGRKRAAAEDGGGGKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1S0M3</accession>
    <name>I1S0M3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG10256.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T07663</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319208.1">
        <property type="nucleotide sequence ID" value="XM_011320906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S0M3"/>
    <dbReference type="FunCoup" id="I1S0M3">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1S0M3"/>
    <dbReference type="EnsemblFungi" id="CEF75634">
        <property type="protein sequence ID" value="CEF75634"/>
        <property type="gene ID" value="FGRRES_10256"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10256"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07663"/>
    <dbReference type="eggNOG" id="KOG4829">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045013_1_0_1"/>
    <dbReference type="InParanoid" id="I1S0M3"/>
    <dbReference type="OrthoDB" id="10261563at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019327">
        <property type="entry name" value="WKF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306:SF2">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10180">
        <property type="entry name" value="WKF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WKF" evidence="2">
        <location>
            <begin position="108"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF75634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="369" mass="40599" checksum="C26EEE14F303D21B" modified="2012-06-13" version="1">MSGQVPAWKRLGLKLKQPSDAPEPSFGHPASSSTTPIKRKFDAPQPSNSSQAAKRQKSVSFADAPSNNNNPKFSRTPAKPAKQSKAKSKGPAKKPKPQVPTDLKPALEYLSLWKTARDSWKFNKNHQSNLIKHVFDADGIPASDIETFYDYIQDLKGFVRMRLRESACEVRDQDQSDGAKAFPEGTKDLEATQQRYEEALTKYLNLPVGSKRKGFTEVDYLSDSEEDEVIVRRLVKRMRAELVIDELSDSDETDATTTSSQTVTSSENNATATKNTEKSVKPEGVSGKRRRKLRVNVDDSDSSSSESESDDDDTSSSGSSSSEDESEKKTPAARKAYRKPGEEDSSDSSSSSDDASSEEDSSDDESDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1S2P7</accession>
    <name>I1S2P7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG11047.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T21107</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325312.1">
        <property type="nucleotide sequence ID" value="XM_011327010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S2P7"/>
    <dbReference type="STRING" id="229533.I1S2P7"/>
    <dbReference type="EnsemblFungi" id="CEF86604">
        <property type="protein sequence ID" value="CEF86604"/>
        <property type="gene ID" value="FGRRES_11047"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11047"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21107"/>
    <dbReference type="eggNOG" id="ENOG502SVCB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2133982_0_0_1"/>
    <dbReference type="InParanoid" id="I1S2P7"/>
    <dbReference type="OrthoDB" id="3873024at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124736" evidence="1">
        <location>
            <begin position="18"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF86604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="108" mass="11801" checksum="AABF49DA8F6CAC83" modified="2012-06-13" version="1">MLAKVFSVVLFLSVATAKLHNNCACHNGDSYNYRMTMNACTVYDDADYKWGGVKYDTPSGRCTQENAEAQIAGDQWEDACKEVAAKGFPCADGKGTCFANPKEVRGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1S300</accession>
    <accession>A0A098E1X7</accession>
    <name>I1S300_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG11160.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T21357</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325187.1">
        <property type="nucleotide sequence ID" value="XM_011326885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S300"/>
    <dbReference type="EnsemblFungi" id="CEF87597">
        <property type="protein sequence ID" value="CEF87597"/>
        <property type="gene ID" value="FGRRES_11160"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11160"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21357"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_9_2_1"/>
    <dbReference type="InParanoid" id="I1S300"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124710" evidence="7">
        <location>
            <begin position="21"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="68"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF87597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="493" mass="53068" checksum="93D0966FC25D8D46" modified="2012-06-13" version="1">MKGSTSLIIASSTLLSATSGLQLNKGHDPAVLSVNFEKRARHVSDSLGRRADNVVDMFVDKHGMRVSYWANYTIGTPPQNLYAEMDTGSSDLLVLTKEIEACKKEKCIGNIFNTVNGESWSGYYAKDNFNLGDVKLDSFQFVATDVFNATVACIVSIFGVGLPIGQRAAKKFPSLPWALRNAGEINTAAYSLWLDDDQSGHFLFGGVNKAKYKGPLVTFPIPVTAPSDDEPDKLLVVMEGFGTTNDGSSTTIEFYPRSVLLDTGTIKSRLTEDMALHVLATLGGVISETYGAMVPCEENPKYTLDFTFGELTINVPLAYFTSKSNNVVGIDGVSYCSLFYDPKATYIILGDDFLKGAYVVFDHENMEISLAQYNPDGEKDDIHEIVKNVPGATKAKIIPMKFDPFDGTAMGDPTSVPAGLKTVSMTLLSSRTASASMIGDPMSTNAGLSIAQPTETGDAKGSDDEDSAAVRSLPGKVMSIVVFGIITGLLCIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1S3G2</accession>
    <name>I1S3G2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG11343.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T21831</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325897.1">
        <property type="nucleotide sequence ID" value="XM_011327595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S3G2"/>
    <dbReference type="EnsemblFungi" id="CEF88642">
        <property type="protein sequence ID" value="CEF88642"/>
        <property type="gene ID" value="FGRRES_11343"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11343"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21831"/>
    <dbReference type="eggNOG" id="ENOG502R8GX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_4_1"/>
    <dbReference type="InParanoid" id="I1S3G2"/>
    <dbReference type="OrthoDB" id="3936451at2759"/>
    <dbReference type="PHI-base" id="PHI:5817"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF96">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="333"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF88642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="399" mass="43848" checksum="9B428858602D47D4" modified="2012-06-13" version="1">MAVESRATQIAAVAYTFVIISSIATILRVYCRAVVIKAFALDDWFAVIAQFMFIVFCSYELTGTRYGTGRHFKDIEGDDLVKAMQMWWTCEPTYVLTNMAIKASIAIFLLRICVTRTHRMIIYIATGLTELYSLFFFLLFVLQCRPTSLFWLRYSANPPAGQCLDASVVSNAFYGYSAISCASDWTYSILPMFLVWKLQMSKRTKISVIGILAAGAIASSATIIRFPYLWSLTDIGDFLYSTSDVAIWSTVETGLGITAAAVATLRPLLRSFLGHGSSAEGGGNSARPWQRTGSNHPSVGYLRSHGVSGGEEAFDLHDNAGKRIGVTTIIDHGDDVKAGEGSKRTSRSAESDSVKELRNDWNSSHSDIAADKDGQPRPEKGWNVLVKKTVTQTRGSDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1S3Z0</accession>
    <name>I1S3Z0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG11541.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T15991</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323086.1">
        <property type="nucleotide sequence ID" value="XM_011324784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S3Z0"/>
    <dbReference type="STRING" id="229533.I1S3Z0"/>
    <dbReference type="EnsemblFungi" id="CEF79795">
        <property type="protein sequence ID" value="CEF79795"/>
        <property type="gene ID" value="FGRRES_11541"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11541"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15991"/>
    <dbReference type="eggNOG" id="ENOG502SHSN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_540843_0_0_1"/>
    <dbReference type="InParanoid" id="I1S3Z0"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF79795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="504" mass="56275" checksum="F0179CD823A610DF" modified="2012-06-13" version="1">MLISPSVKSHSETGYVVGLILIATGFCFTGLTFMDHFLNITPPFFRVNKETGFADLTIRPQKFFYRDLPHSSISLAKEADVFCDGSTISFDQIGYTAAFLHLSDVVGAIFLKLSGAGRDLHHMDWYHHYRAEKIQMLREWCKDSRSTWSDALSLVDMTAGIETESIRVSKGLVSTILLKLLMWTTGFRATDTRDSIYGLWGIFQHVANKQSVTVPEHLMPNYNIPASRVLESMTAEILEATGDLTLLALAKDPARRVTTDLPSWCPDFGPSTGMNSIFSPSFKSVTRPNASGAVRYGATRIGKAFKVHDRFPGTVRLLGGSFETVGTSGVHDWVELLLKTDRTYAHTWQSSMEAFWRTLIWDHDSINRPAKLFNSKGFESLVIMWMAGVFQKALAQDGRATADKILEAYRILDDLASHIPDSAFPSYTEFISLLVKLNLLDGPSEKVLSMSEQAAWIENIRNTGKTYFTVIGVTSRYQRPFLTDNGHLDSSCESTQAGDEVWIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>I1S4A4</accession>
    <accession>A0A098D0J4</accession>
    <name>I1S4A4_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">beta-glucosidase</fullName>
            <ecNumber evidence="10">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FGRAMPH1_01T00261</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="10"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF71930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315685.1">
        <property type="nucleotide sequence ID" value="XM_011317383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S4A4"/>
    <dbReference type="STRING" id="229533.I1S4A4"/>
    <dbReference type="EnsemblFungi" id="CEF71930">
        <property type="protein sequence ID" value="CEF71930"/>
        <property type="gene ID" value="FGRRES_11671"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11671"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00261"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_4_0_1"/>
    <dbReference type="InParanoid" id="I1S4A4"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000006">
        <property type="entry name" value="Beta-glucosidase H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="11">
        <location>
            <begin position="403"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF71930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF71930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="841" mass="92169" checksum="9FCEC4E597D89BAD" modified="2012-06-13" version="1">MSPLMTDTRVGELPVDELLERLTVDEKVALLAGMDFWHTTPLPHHSVPSIRVSDGPNGVRGTKFFDSVPSSCLPCGTALGATFDADLLAELGHLQGQEAKAKGAHCVLGPTLNIQRGPLGGRGFESFSEDPLLSGILSGYYVKGLQEENIAATLKHFVCNDMEHERMAVNVIITDRAMREIYLMPFMLAISIGNPRAIMTAYNKVNGTHVSESKEILQKILRDEWKFDGLVMSDWFGTYSTTGSIHAGLDLEMPGPTRWRGTVLSHAIMSNKVNEQQLDDRVRNVLNLVNYSLASGVPENAPEKRLNRPEDEALLRRAASESIVLLKNNDNVLPFAKFKNTAVIGPNAKIARYCGGGSASLLPYYSVSPYDGIANQCEKVVFSQGAQDHQMLPQMGDVLRTEDGQRGFSWRAYNEPASVKGRVPFDERVLVDSNCFFLDYEHPDLAPVWYSRAEGIFTPDESGLYDFGLEVEGTGKLYIDDALLISNVENQKPGETLFGSGTVEEKGSVELVAGKDYKVRVEWGCFKTSKLPPCGPVGGRHGGLRFGACRRMDPAQALEDAVQVAKSVDQVVLVVGLNGELESEGTDRPTMDMTARTNALISKVLAANPNTAVVVQSGTPVGMPWIDEAKAVCHAWYGGNETGNAIADVLFGDVNPAGKLPLTIPRRVQDNPTYLNYRSDSGRVLYGEDVYVGYRCYEKLDNKPLYAFGHGLSYTSFSLQDLSVQVDDNVCKVTLWVTNTGSRAGAEVIQVYVAPPSTTAVARPVKELKAFRKVRLEAGEEKHITIDMDAVLSTSYWHEGRDKWCSEKGLYDVLVGRSSADTPLQASFEVTRTSYWTGLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1S4C3</accession>
    <accession>A0A098D249</accession>
    <name>I1S4C3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T00431</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315767.1">
        <property type="nucleotide sequence ID" value="XM_011317465.1"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF72016">
        <property type="protein sequence ID" value="CEF72016"/>
        <property type="gene ID" value="FGRRES_11690"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11690"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00431"/>
    <dbReference type="eggNOG" id="ENOG502QQIR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000570_3_0_1"/>
    <dbReference type="InParanoid" id="I1S4C3"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052957">
        <property type="entry name" value="Auxin_embryo_med"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387:SF0">
        <property type="entry name" value="PROTEIN NO VEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387">
        <property type="entry name" value="WU:FJ29H11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF72016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1338" mass="152886" checksum="FBEE0C1C6E04E6A2" modified="2012-06-13" version="1">MTSTQEAEQFIQSLSGYSTDYVEKSSKRLLFELLRHINGKTFATAEAAKATPFLTLKVYPGRIIAECNSDDLTKEDLQAICQSVDKEQTKAVNFKTIVAATKRTHIQSGNFSFEFQHNIFDLDNNHIMRPVWVTPAQTVAVGTTRITLYLHDQGSKDEIQYLRNIIVSQFEGLRQESILFLNNIQSLKVESREDDRILRSRHFEKQTVDEYRVSVKVITVDGERSEEDTRTHLFHLTKSDDPATNLILAFPLTDDFKAEVGSTSTKIFNLLPLTQGSLGFHINSLLDVDDQNGAITVSTNNIGIRNEIANLFFNAILQFCEHPFLRYQWPLFLKAGVAEEDPFWSLLRSDIRNWISQNPVFVSRHVKHWRLISHLAAPGWDTQDEAGNPLLDDEINDPFLSSRYPPGVTGILRCYGLAALSNAQCVELLKKHFNNPFLEYRMMFRTKEWHSALTRLISKLLNNSEHSDTIKSFPSLILRYGTTVSAASAVSQPVYFPTTNNIEIPKTLTLRVIKDTKGDGMYPTTLYKQLGVTEASMAQVRTLIMEAFSASNSFTLDEIKSYLRYLYLTHHHQPCSPPHEELYSTVKIITQDKKTKSLRDSTIYLPGTEHPYTTQSLFGSGMFGRCETIDYLHPYLLKDAPKQPEIGHIAWKTWLCDCLGMKGRLSLFRLIPYHGRDSTRGALSTPETIDSLSEHCANLLENRPDVFLGLLEHLWGFEGSRIMESPTLLSEIRKLPAKSLCGLDRLVVLRDTWVPIQGLKEHVKTFMDSPDMFPFLKLENGIDKNMALPGNKWWFLTRDLGVKRDYSMDFLLAILDSIVQSCKTLSSSQMVKVSNLYYSIRTMFLTCNNGEKKRALEFFENSGILYMDESGPIWTGTSSCLWTAPPDMISRYSLKMFYEDKVVDKDKLQGISDLFCKVLGIQDATVEDVVEELCLLRDEGCEDLARITNNYKYLDNDIKSSCSIRTAFGEQAVIFIQDDDISIWFSTKECFWSEAETTPMECRLKRCYPGYKHFFLEKLGVRTSSYDKLVNFTSTDVEEAKKCLLSFMDESDALYEYEPEPMAKVKIFPVQYPTSEAQPRPRIELCSLDTEFCIGDRDYLVKSLQPQVKMLSFSITEIRMLQPLFSWLSMEDRYLSECVEEAITGIPPSNFMPRDATAIEMALMNKAYHIARVAETFKSYGPYGNALSLYNMLRKIKIAKVDNMSIDLLLCQDDEVFTSRSSQKTIAYISEHIDSMAIYVNYDDSDEQLCLFSTLPSKLQQWLMQDLRSLCFESFEVTNALTSIFACDADILDDILHDQGMAELPFENLDKVQSKPYTGAQQPRVDQDKALTLTIRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I1S4P8</accession>
    <accession>A0A098D2M6</accession>
    <name>I1S4P8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T01809</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316419.1">
        <property type="nucleotide sequence ID" value="XM_011318117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S4P8"/>
    <dbReference type="EnsemblFungi" id="CEF72705">
        <property type="protein sequence ID" value="CEF72705"/>
        <property type="gene ID" value="FGRRES_11816"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11816"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01809"/>
    <dbReference type="HOGENOM" id="CLU_2320599_0_0_1"/>
    <dbReference type="InParanoid" id="I1S4P8"/>
    <dbReference type="OrthoDB" id="10271990at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF72705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="99" mass="11410" checksum="BC3BF3C32612FE2B" modified="2012-06-13" version="1">MWTGREITTATSYASQERYPGAVFPCRQQVGEKSNKATVRSTLPGKRHLRGRVIIEYAVNLKRDAGNEFRFFSDVTVAELHLHCISKKGKEFRRRQLLN</sequence>
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    <accession>I1S567</accession>
    <accession>A0A098D4G8</accession>
    <name>I1S567_GIBZE</name>
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            <fullName evidence="1">Chromosome 1, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317509.1">
        <property type="nucleotide sequence ID" value="XM_011319207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S567"/>
    <dbReference type="STRING" id="229533.I1S567"/>
    <dbReference type="EnsemblFungi" id="CEF73854">
        <property type="protein sequence ID" value="CEF73854"/>
        <property type="gene ID" value="FGRRES_11985"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11985"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04093"/>
    <dbReference type="eggNOG" id="ENOG502S11B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073382_3_0_1"/>
    <dbReference type="InParanoid" id="I1S567"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Flavunoidine_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350:SF19">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF73854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="211" mass="23447" checksum="D7686BE8ABC192E3" modified="2012-06-13" version="1">MATGPRPKDATAAEPLLAPAWVNPDLGRLMVVHKDVITPAADGNSSDSDSSASTSTSTKSYYKSWAESLVDLPAGAIFARINGVTPTSKRDYDTVQSGTSSHFIWNSDLYYCNHSCSPTLECDTSTWEVRVSRDRPLRKGDVLSVFYPSTEWIMAREFTCWCGAGEQRCCGTIRGARDMHDADLRRFWLNRHIYELRKQEGGEVGGERQQG</sequence>
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    <accession>I1S6X3</accession>
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        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
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        <name evidence="4" type="primary">FG04721.1</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="348" mass="38673" checksum="DEB175B6DC5D4DC4" modified="2012-06-13" version="1">MTQDHKHEALQPIHPSMKNKLDPVFEKLYNDNVANTPLKPIDLEVLRSKYSVLYSYGTGPAPEVAREYDAQITTREGIVLDIRVYEPDTAGPWPVHIDYHGGGWGLGDLNTESHICKHICKVAEVAVIDVAYRLVPENAFPCGVTDSFAALQYIHKKGAERFSIDPERISIGGVSAGGFISLALAHMARDAGIPLKLVAVGTPVIDDLSKYSSASDSPFASMQENEHAPTLNWGRLAWFDKLKWSSLGSDPEEIARKRQQIPEIFANLFKADDFTNLAKTVIYTAGADPLRDEGEAYGMKLIEHGNEVTMKRFPGVPHPFMHMDKDLWQAREFILQTASAIRDALHHS</sequence>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324435.1">
        <property type="nucleotide sequence ID" value="XM_011326133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S7J9"/>
    <dbReference type="EnsemblFungi" id="CEF87766">
        <property type="protein sequence ID" value="CEF87766"/>
        <property type="gene ID" value="FGRRES_12822"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12822"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18877"/>
    <dbReference type="HOGENOM" id="CLU_1749831_0_0_1"/>
    <dbReference type="InParanoid" id="I1S7J9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124854" evidence="1">
        <location>
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            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF87766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="149" mass="16439" checksum="C1F275E66B61A7F5" modified="2012-06-13" version="1">MASMILLLRTYLYALTVSALSTVAAALISPTTAKITSMHTFFIKGSNGETSVIQKDGAEEPVCCRKKTFRIQSSDDIDKDKESKQSLWRRIAGSILPGIHQAKARFEEYEAGIYRRIEEFTSDAGQVEGACEVLLGVGEKKTEKLKTNC</sequence>
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    <accession>I1S9I8</accession>
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        <submittedName>
            <fullName evidence="7">Chromosome 4, complete genome</fullName>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328657.1">
        <property type="nucleotide sequence ID" value="XM_011330355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S9I8"/>
    <dbReference type="STRING" id="229533.I1S9I8"/>
    <dbReference type="EnsemblFungi" id="CEF85370">
        <property type="protein sequence ID" value="CEF85370"/>
        <property type="gene ID" value="FGRRES_13519"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13519"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27857"/>
    <dbReference type="eggNOG" id="ENOG502S098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006016_0_1_1"/>
    <dbReference type="InParanoid" id="I1S9I8"/>
    <dbReference type="OrthoDB" id="5093543at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07491">
        <property type="entry name" value="Peptidases_S8_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="6">
        <location>
            <begin position="762"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="770"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="813"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF85370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1101" mass="126127" checksum="34166D10C3661E7D" modified="2012-06-13" version="1">MEETSDSFQDLEGQPNQPRSLTNNEVSDENHGQDELGDSSEYSDTDDDEDEEEVHGDSNQNLARTYEQQAKEFKDQATHIKAQLDRQMDNFASQCPDNDNADARNRFYRQFRHHMAPPKAQIVKHLSVWQWNILYYIADEKQSDRPCDWLVGRLAKEFPSLLNERMPNGGLTVLLKAVKEHNFAFIKAVLDSGISTTNLVKIVVERDVDKKNCIHYAVSDGFDPEITIRLLQHTTGETLGHQDNKGLTPLHYAVEYERCLPEREEMVKALIKRSDVAFDLRSRKPEELSVYQHHVRSREKYGKKKELRRMERERKEKEKQSKDYKEKTSDATPGRHETGSMSRKDEAKNSKRLSEQPNRMGFKMREGADLKVPGGSESNNMDTLQLLAGSKRDARDQNQFGRPLTRTRTGSQKPPNPKKVSSRKRPKLPKPSEDVADRILKELKLHYLRTALCQESHWQYGQRGSRRNPNTAIQFLYGDNEQETQIGFEFPPKIPKTPNEINFRDFTKSYESLKFDKVLQHVEFRQMTVKSPPVKRPDWTDSEGRAGTGRKDVYYFFRWLSKTKSVENIIHLIVEDGYGISHSDEAIEESLKYFNIEILDWRKTDLDPMTLQIACRNSDLREIHLWWDGNNAVLRAWSEPDGLVKITTLQVIHLHETTKNIESSNRTKARIESFKTRLREHRAKVLQPLECYHYEAYEKNPSRTEGQMPTEKLEQRAKIDSYQWLSVMDRFADGIASLEPLECFQGEDDYLKHPSLPDELRKDVKVALIDDGVNFLHKSLAENIDGGKSFDREYDDGYRPGLREPFHGSATGHGTCMAYMIRRVCPRVKIFGCKLNVLRGNVDGKASFTAKSAADAVEYAVARKFDIISISWTVQLQKDEKHDNSADINRLENAISLATTNGILVFCSAPDIGRASKETLELYYPFGCKRSSTDLFKIGAAKADGLSFAWMGHEETVNYILPGHKVAPRETDNLPEEDDTPKTGSSVATALASGLAALIIHCVRLAAIYNIYTNNRDSSSVSEASVRAIKRFPAMKQALARFYSNDGERQTSDRNLRVENFFDRPGHIMGSNEVTEEDKWKEVVNIARDLVSYKTITQTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I1S9R7</accession>
    <name>I1S9R7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T26949</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328226.1">
        <property type="nucleotide sequence ID" value="XM_011329924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S9R7"/>
    <dbReference type="STRING" id="229533.I1S9R7"/>
    <dbReference type="EnsemblFungi" id="CEF84133">
        <property type="protein sequence ID" value="CEF84133"/>
        <property type="gene ID" value="FGRRES_13598"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13598"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26949"/>
    <dbReference type="HOGENOM" id="CLU_2264009_0_0_1"/>
    <dbReference type="InParanoid" id="I1S9R7"/>
    <dbReference type="OrthoDB" id="5072064at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF84133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="103" mass="11287" checksum="8E934A86F8C79116" modified="2012-06-13" version="1">MKSSPYRLTPKSVKNSTPLLTCLLACSRPNRKRAGHCSTYVCTSPLALPTPPTYLPRRDIFVAFATKLAIPGSEASRPRLRRPTQTETTQASNCRSGVAIEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1S9U1</accession>
    <accession>A0A098DQS4</accession>
    <name>I1S9U1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG09664.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T26563</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328043.1">
        <property type="nucleotide sequence ID" value="XM_011329741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S9U1"/>
    <dbReference type="STRING" id="229533.I1S9U1"/>
    <dbReference type="EnsemblFungi" id="CEF84200">
        <property type="protein sequence ID" value="CEF84200"/>
        <property type="gene ID" value="FGRRES_13622"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13622"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26563"/>
    <dbReference type="eggNOG" id="KOG2354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045565_0_0_1"/>
    <dbReference type="InParanoid" id="I1S9U1"/>
    <dbReference type="OrthoDB" id="340681at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF84200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="403" mass="44206" checksum="3A84F4E2A76D1782" modified="2012-06-13" version="1">MSSVTDTPTPTASMDVDQMDVDATVKPSTTNNATMIDDDDDDPVTATYNVFINPSLPLGRRLLVLQHPNRTDEATRPPPTELRVKAQAGMVEVDVPLDNTVAYDREKGLKWGKTLNASMATKNGGSHGLAGGFGFGTVQARGGRKKVDEEDEVMDWTEAVRQDKVLRTQTLGGQYPEYKEVQHMVGVFQGKDLHLTPVSSLVHLRPQLHHIDATVQQERQAAATKDSAPTTAGGTARAIHMTVKATGDGETVTTETMADRLRSVQTEHWRTMHYTDENEEAAWEVYNESLFLRPTQEDGAEEKADDADKKEQALEESVPKFARRWNDDDLLYAVSGIKRPKTPEPVVKEEPKSAPPKQLQQPAPESEEARKPKLRPRGGAAGGVARRGGKPRAATSKTVNIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I1SA34</accession>
    <accession>A0A098DC53</accession>
    <name>I1SA34_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FGRAMPH1_01T07483</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319129.1">
        <property type="nucleotide sequence ID" value="XM_011320827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1SA34"/>
    <dbReference type="EnsemblFungi" id="CEF75546">
        <property type="protein sequence ID" value="CEF75546"/>
        <property type="gene ID" value="FGRRES_13715"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13715"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07483"/>
    <dbReference type="eggNOG" id="KOG0253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_52_2_1"/>
    <dbReference type="InParanoid" id="I1SA34"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
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        <location>
            <begin position="114"/>
            <end position="576"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF75546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="582" mass="63770" checksum="A51A97BA44319169" modified="2012-06-13" version="1">MRISWRLGSGYVESVDDYIGVLVPLEEAHLYSQAAKAKSASHGGKQEENEMDDLEMKEEREGMLGGDAAEYTIEGLRKEMREGRRGQWTTYEIKSKLMNKAVGDIGMGSYNWQLFVLCGCGWFADNLWMQGVSLCLPSLSGEFGVDEKTVRYTTSALFIGLSIGSFFWGIGSDFLGRRIAFNMTLLITSVFGIMSAYAQSWGSVCFFFAALGFGVGGNLPVDGALFLEFLPDASSALLTLLSVWWPFGQLVSSLIAWFFIGNWPVEQGWRYFIVTIGIVTFAMFVVRFFIFHLFESPKFLLNKGRQHEAVAVIHGLAYRNGTRTWLTSELLDQVACEDGDDMAHVAEKKVPALSTMGVIQEKLKSFSGERLRPLFQNKTLGMATGLVWFCWATIGMGYPLFNAFLPQYFARAHNEASGNVQSETDAISSDTYRNYAIASVMGVPGSLLAAYVIDHLSPFVGRRGTLASSTFLSAISLFLFVFYGTTSTAQLLMSCVEAFAQNIMYGVLYAFTPEIFPAPVRGAGTGVASFLNRITGLMAPIIAATVPGDGATTPIIMSAVLILSAFVGICLIPIETRGASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I1SAA1</accession>
    <name>I1SAA1_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
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    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T08371</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319539.1">
        <property type="nucleotide sequence ID" value="XM_011321237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1SAA1"/>
    <dbReference type="STRING" id="229533.I1SAA1"/>
    <dbReference type="EnsemblFungi" id="CEF75989">
        <property type="protein sequence ID" value="CEF75989"/>
        <property type="gene ID" value="FGRRES_13782"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13782"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08371"/>
    <dbReference type="HOGENOM" id="CLU_2346868_0_0_1"/>
    <dbReference type="InParanoid" id="I1SAA1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124855" evidence="1">
        <location>
            <begin position="22"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF75989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="97" mass="10984" checksum="C6F8028720F651F7" modified="2012-06-13" version="1">MTISFTKALLLLTSAVALTTANPIPDEAHNTTSADMGILAKPDFFCNDNELSKKCRGPPYNFRCTNDNHINYDEPYYQCRDKTRCSCHYPCNNIKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1SAG3</accession>
    <accession>A0A098E3M1</accession>
    <name>I1SAG3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 3, complete genome</fullName>
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    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T21381</name>
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    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325179.1">
        <property type="nucleotide sequence ID" value="XM_011326877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1SAG3"/>
    <dbReference type="STRING" id="229533.I1SAG3"/>
    <dbReference type="EnsemblFungi" id="CEF88701">
        <property type="protein sequence ID" value="CEF88701"/>
        <property type="gene ID" value="FGRRES_13844"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13844"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21381"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_852715_0_0_1"/>
    <dbReference type="InParanoid" id="I1SAG3"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="5"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF88701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="326" mass="36715" checksum="54EEF8A27FF22B62" modified="2012-06-13" version="1">MKGSRGQTALMFAVGSECKPVVELLIKNNANIDIQEEEGVTALIGCVEEGLDEMAKLLLQHGASTHVKDERGLTAFDHIIDKGNIQICHHILEQITDTERMDFVGRKRMAEACRNSHTEMVRLFLENGVRTELPESQAQTTFPFSESVLGVAIATDQRDILELLLDHEFTYSGLPVWRTNLLCECVISCALECMMSLIIHYRWGIDEVDANGDMPVYVAIREAWTTYETPNHFYGIIKTLISLDWSPQGIVVNALNNQLQSPLMLAVEYCGTERFVQQILADEQVNINYQGCACIYVLYISCYYISFLDSHLTHLGRVESNPKSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>V6QWP4</accession>
    <name>V6QWP4_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG01360.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T03351</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317151.1">
        <property type="nucleotide sequence ID" value="XM_011318849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6QWP4"/>
    <dbReference type="FunCoup" id="V6QWP4">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="229533.V6QWP4"/>
    <dbReference type="EnsemblFungi" id="CEF73480">
        <property type="protein sequence ID" value="CEF73480"/>
        <property type="gene ID" value="FGRRES_01360"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01360"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03351"/>
    <dbReference type="eggNOG" id="KOG4455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110781_4_0_1"/>
    <dbReference type="InParanoid" id="V6QWP4"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF73480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="118" mass="13091" checksum="C0AE13414400270F" modified="2014-02-19" version="1">MPSERELQINPIVPESMIHNTKALSNLHSLTASLFGVTAGVLGLESYYGFLVYIVFSFITTLLFYVLKVAPESLPKGHAPLDPSRFYRGLFDFWVGGISNGISGFVLTWTLFYGLVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>V6QYL1</accession>
    <name>V6QYL1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG01712.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T04167</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317544.1">
        <property type="nucleotide sequence ID" value="XM_011319242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6QYL1"/>
    <dbReference type="EnsemblFungi" id="CEF73891">
        <property type="protein sequence ID" value="CEF73891"/>
        <property type="gene ID" value="FGRRES_01712"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01712"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04167"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="InParanoid" id="V6QYL1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF81">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF73891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="514" mass="57744" checksum="AD1F6FECF6E47090" modified="2014-02-19" version="1">MATFSAQDALDVKKMQPFDTHDVEADIKQGTVEDLDEAELFLQQHGIPHSRLNELMADEEALKKLRRKVDWTLMPLLCGTYLLQYVDKQALGYSAVFDLFTTTGMTPDEYSWMASIFYFAYLVAEWPASYLTQRLPTGTVVSSFVIIWGAILCLTAACHNFTGLAICRFLLGTFEAVITPAFMLIVSQWFRRETQPSRAGLFYCFNGFGAMFGGILFYGVGQAKGWAVWRTIYVLCGGMTICWGIVLFFFLPNNILTAKRYTIEERAMLIAQSARNKTGVFNRKIKWNQIREVFSDMQIWLLFFYVLLNEIINGGIANFSKLIVKGFTHDALLTTAYGIPYGACNAIFMFTGPFVASKFKNVRTIVMCVWLIPTLIAVNLFWQLPRSNKGGLLAGYYMCASFVGALIVALQMPASNVGGYTKRTTATAFVFLAYCIGNIIGPHGWVGSEAPIYQTGCKLIIGCVAGQVVIAIILRFVLIRRNRLRDEQGPVIEDENAALQDLTDFENPNFRYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>V6R476</accession>
    <name>V6R476_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG04400.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T15193</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321206.1">
        <property type="nucleotide sequence ID" value="XM_011322904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6R476"/>
    <dbReference type="FunCoup" id="V6R476">
        <property type="interactions" value="727"/>
    </dbReference>
    <dbReference type="STRING" id="229533.V6R476"/>
    <dbReference type="EnsemblFungi" id="CEF79397">
        <property type="protein sequence ID" value="CEF79397"/>
        <property type="gene ID" value="FGRRES_04400"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04400"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15193"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="InParanoid" id="V6R476"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000329">
        <property type="entry name" value="GTP-binding protein rhoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF79397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="195" mass="22088" checksum="54F37DF25A2D7F25" modified="2014-02-19" version="1">MAEIRRKLVIVGDGACGKTCLLIVFSKGTFPEVYVPTVFENYVADVEVDGKHVELALWDTAGQEDYDRLRPLSYPDSHVILICFAVDSPDSLDNVQEKWISEVLHFCQGLPIILVGCKKDLRYDQKIIEELRKTSQKPVSPEEGEEIRKKISAYKYLECSAKTNEGVREVFEHATRAALLSRSTRSKSHKKCLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>V6R8C4</accession>
    <name>V6R8C4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FGRAMPH1_01T16843</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323480.1">
        <property type="nucleotide sequence ID" value="XM_011325178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6R8C4"/>
    <dbReference type="STRING" id="229533.V6R8C4"/>
    <dbReference type="KEGG" id="fgr:FGSG_05001"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16843"/>
    <dbReference type="HOGENOM" id="CLU_107649_0_0_1"/>
    <dbReference type="InParanoid" id="V6R8C4"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF57">
        <property type="entry name" value="PLASMA MEMBRANE PROTEOLIPID 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010223181" evidence="8">
        <location>
            <begin position="23"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SCB64681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="163" mass="17768" checksum="7AAA2C9A6E0768FD" modified="2014-02-19" version="1">MCSADFFLAFLAILFPPLPVWVKCGLCSADSLINILLCCLGYIPGLIHAWYLIAKYPEPPYEYESLPQDREGNRVTYVYVQCPPGPHQHGQNNKQPKPQPKPHSGNTGNMNYGTQNAASSSHPAPQQQQGVTNNGEGSSSNDQSVPPSYADVVAGDHKIQSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DDG2</accession>
    <accession>A0A0E0RYZ2</accession>
    <name>A0A098DDG2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG08193.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T09329</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DDG2"/>
    <dbReference type="EnsemblFungi" id="CEF76467">
        <property type="protein sequence ID" value="CEF76467"/>
        <property type="gene ID" value="FGRRES_08193_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09329"/>
    <dbReference type="eggNOG" id="ENOG502QR7D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DDG2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF1">
        <property type="entry name" value="DUF1237 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010018651" evidence="2">
        <location>
            <begin position="22"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF76467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="519" mass="58215" checksum="6FAC9114FFB5D403" modified="2015-01-07" version="1">MLYSYARQLLLGALALQSADAASWKDYKPQSRTPSSCPDYVDYSQKPHEPLSSGKLKLPFMRPSEECRTFKSPAVEKVIKDMKKRIKNPDLARLFENAFPSTLDTTVKYFDAKKNLAFIVTGDITAQWLRDTGNQFAHLYKLLPQDENLKDLVKAIINTEARYISEYPYCGAFQPPPESGLSPSVNDYAELVTVNPPVDNQTVFECKYELDSLAGFLKIARSYYNNTKDASFINDNFKSAMTQILRVIDEQSQSTWAEDWSYVSYYNWTGNAGSLSPPVPNSGNGEPKLANGLVACSHRPSDDLSVFNYITSDNAMMSVELDNVANVLDKAKSQTKLAKTLRSHAETIRQAVWNHTLTSNGIFAYETNGYGGQYIMDDANVPSLVSLPYLGFLDRSDKTYQKTKSLLFSRANPYYAVGKTFRGIGGPHANATNPWPMAHVSAIYGTDDDDEIKERLNIILENTSGLGLVHESVNIYNSTVFTRPWFAWANSYFAEMVLDLAERKPGLIFKDNKPYVIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DE14</accession>
    <accession>A0A0E0S128</accession>
    <name>A0A098DE14_GIBZE</name>
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        <recommendedName>
            <fullName evidence="1">holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
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    <gene>
        <name evidence="6" type="primary">FG08779.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T10801</name>
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    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DE14"/>
    <dbReference type="STRING" id="229533.A0A098DE14"/>
    <dbReference type="EnsemblFungi" id="CEF77203">
        <property type="protein sequence ID" value="CEF77203"/>
        <property type="gene ID" value="FGRRES_17746"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10801"/>
    <dbReference type="eggNOG" id="KOG0945">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DE14"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
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    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
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        <property type="entry name" value="AASDHPPT_N"/>
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    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
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    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
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    <dbReference type="Pfam" id="PF22624">
        <property type="entry name" value="AASDHPPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase N-terminal" evidence="4">
        <location>
            <begin position="35"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="3">
        <location>
            <begin position="128"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF77203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="292" mass="32795" checksum="CB6FCBF44C953CCC" modified="2015-01-07" version="1">MSQTQSSPTAIQWVIDTRPLWPLALETKDLTTSASRALSLLTTEEQAAVMRYYHVRDAKLALASALLKRYVISRFCQVPWSEAKTTRDVRTKPVFISPSGDEPLIFNISHQAGLAVLLAVHNPPEGLAVGVDVVCPTERRDRDLRSLADEGWPSFVDMHADVFGPGEVAALKHMNPGTAISERDCALRYFYALWCLREAYVKMTGDALLASWLKDLEMRDFAPPEDMRKVQEAWLRGIKVDGVDLKLMPFLEEYMISTAVRHGLNGETIDLKDFQSLDIEEILTFGERLPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DG29</accession>
    <accession>A0A0E0S1N5</accession>
    <name>A0A098DG29_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PAN2-PAN3 deadenylation complex subunit PAN3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Poly(A)-nuclease deadenylation complex subunit 3</fullName>
            <shortName evidence="8">PAN deadenylation complex subunit 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG08928.1</name>
        <name evidence="8" type="synonym">PAN3</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T11215</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PAB1 (via PABC domain), conferring substrate specificity of the enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The N-terminal zinc finger binds to poly(A) RNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. PAN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DG29"/>
    <dbReference type="FunCoup" id="A0A098DG29">
        <property type="interactions" value="636"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A098DG29"/>
    <dbReference type="EnsemblFungi" id="CEF77410">
        <property type="protein sequence ID" value="CEF77410"/>
        <property type="gene ID" value="FGRRES_16942"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11215"/>
    <dbReference type="eggNOG" id="KOG3741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DG29"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3700:FF:000001">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03181">
        <property type="entry name" value="PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pan3 C-terminal knob" evidence="10">
        <location>
            <begin position="436"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Knob domain" evidence="8">
        <location>
            <begin position="484"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="445"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="282"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="343"/>
            <end position="344"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF77410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="583" mass="65549" checksum="D2C26FC74C9F0F4E" modified="2015-01-07" version="1">MADSDKFRSKKSLNVDSPSFTPASIGSKKPTFSSQAASAPAFTPRGLGSATPVGLQDSDSSLFNPASAREFTPTFDINTTTATNGSAQDSGIPYDPFTVNQGLATPQFNPYAEDPTLGGHGPGYFQAQNAFATPVQPLQHHLYFPVAPHRDDLMPYHRVPHDFFLPEKEREEIARKLEAAGQVLPNSQLPQLDNYHNLVPLDTTHRKNANIFGYPSWVYKATATKTGNLYCLRRLEGYRLTNEQAIKLVKEWRRVNSGSVVTIIDAFTTRAFGDSSLVFVQDYYPLSKTLVEAHLTPSTTHGNRFQAKTPVVENVLWVYISQLANALQAIHSNNLAARCIDPSKIILTHKNRIRLSACSILDVVQYDAHRSIQELQQEDFIQFGRLLLCLTTNTLPVHLTNYQMSLEQMSRAYSVEIRDTILWLLTPQQPPAQKGIEEFVRGIAGRITFTFDQNLQALDKANTDVMREIENGRAARLMMKLATINERPEFEGDRTWAENGERYMLKLFRDYVFHQVDNNGKPVLDMGHMLRCMNKLDIGSDERICLTSRDEQTSFLVSYKELKKMLANTFGELVKGSKSGRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DGQ1</accession>
    <accession>A0A0E0S0V6</accession>
    <name>A0A098DGQ1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="5 14">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FGRAMPH1_01T10657</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="14">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="5 14"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DGQ1"/>
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        <property type="interactions" value="812"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A098DGQ1"/>
    <dbReference type="EnsemblFungi" id="CEF77131">
        <property type="protein sequence ID" value="CEF77131"/>
        <property type="gene ID" value="FGRRES_08721_M"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DGQ1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:mitochondrial intermembrane space"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:superoxide dismutase complex"/>
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        <property type="term" value="F:copper ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016670">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:intracellular copper ion homeostasis"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:intracellular zinc ion homeostasis"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901856">
        <property type="term" value="P:negative regulation of cellular respiration"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="12 14" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="16">
        <location>
            <begin position="88"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CEF77131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="228" mass="24305" checksum="524590B9E08BD0F8" modified="2015-01-07" version="1">MRAEGSADNEGVQSRSWWKAPCLVPSEARVSRCFGPRFLFKTPLSSPLHLHHSILNCFIPLPKFPRNKNKKTVKMVKAVSVLRGDSKVSGTVVFEQESESAPTTITWDITGNDPNAKRGFHIHTFGDNTNGCTSAGPHFNPHNKTHGAPSDETRHVGDLGNVETDGQGNAKGSVTDSLIKLIGPHSVIGRTVVIHAGTDDLGKGDGEESLKTGNAGPRPACGVIGISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DIS1</accession>
    <accession>A0A0E0S492</accession>
    <name>A0A098DIS1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T13027</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
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    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="CEF78317"/>
        <property type="gene ID" value="FGRRES_03500_M"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13027"/>
    <dbReference type="eggNOG" id="ENOG502SJW1">
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        <source>
            <dbReference type="PROSITE" id="PS51096"/>
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    </evidence>
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        <source>
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    <accession>A0A098DNT5</accession>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="CEF79621"/>
        <property type="gene ID" value="FGRRES_12224_16089_M"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15643"/>
    <dbReference type="eggNOG" id="ENOG502T495">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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            <end position="1505"/>
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        <source>
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        </source>
    </evidence>
    <sequence length="1573" mass="177874" checksum="68991E8CB48F0408" modified="2015-01-07" version="1">MDESQTHQTPIPDWGMDPPDYFDEDSIYNEEDPEDPSLRNTRKVALRPLAEVYREGAVRATFEGNPDEAFGLVNETSDYIMTVDRLVWIDGWYTTSGDGPNKTHENPMTLVVLNVKFFDKRPDDSRVIGGAVAELRFFSDHKKEDNPEIVAWGPFRHQERWNVSTGYVKVTTKSELRASAGFADQQLSGSLGRDKELSRTIVAFDEGYSTHLYPQNFKSTEGHRRPNGVQWCVRQNHLHQQGVESEMRFAALISRPEQMRPYHVSFRVQVHTGSKEIARNTVQRLSRRPVGDQINWRTEPNLDKMHRCFAEGVPIAESIDSDNLGQLVKDPNDSQNLDQEWLKPHSRPELSQAVQAQTRADPEEGSDTFEAQVAVDVPGIAEISMDLQQPESVAGDQSQQPKENRAPNYLTRITTTEQGSPITDDRRRTKQDTADVTCRPSSLDYSAGQQRLRDGEHDRLVSLEIRAAQAEARLAAQDQLILKLQQTVSTMEQALCTEPCSSMFTQSTTDTMDISSRPGSKKRTVPDVMGTTSRPGSGKRPLPGSLTRTPTGNATLSTKDLHQADFPKLANPKDAKENVSSSRVRSKLLERLKEPNKNDSFKRLIEEISNIIFDELKKEEKAIEGIKDFLKDEGVDDCLRWHLLFYAVNIDELGNARNESRLARLQLSQALITERPYLSFENPSVIHRAKELYQNDCCSKNLHQGYKVKHTPLHKAAESGNAEAIEVMISEGKKFYDDDRVGGRLGSLRAMKLRDCKQPSSESWTLVNMVRLTGKESGPTALNLAAEAEYGSSDTIIKLLEVSGIASGDDTFADAVEEGKLEIVEAFLSKNDTDLFRTVITEASLKSALTNLNNANHNEETPSDARDQIAELLISRIQDSLRLDDIAEDIIATGSKKVWEACPETMLSSELEQHLVHMAVKHQKLNFVQHFLEKYPTSVCELWGGSKHTGQHYPLWYNNHDKDGNRIQKPFGTVRQNIRNEIVTKMIHQIEEMEKLSDAFNNCEETVGQLCLDLSRFDSKGFRVSEFVDSMISQADNDLITYEQTLRYVEFPPLDMLPEEREIYKDDCPLQFQHTELFKILKWLREEKNVKTIIRLKASDRLVNCHDQRLMADGVKLFNVKVLDWKVLDLCLDIFDETCRENITDLCLYSSGNRAVISHWFSPTGFKSFKNLETVKIYLIKETCTTAHRNAVYRELINRIDPEDEHPSIYPQRICWYPKQKLADLSKIAERIDPQLGRWLLNLKTKYEGDMDFRRTKVAILDNGVLSISPKTSTMATSRRSSKSSEQFTWKANDKKNDNTHRSNLAYEAGNIDITSSLSSRIKGGRSFVEGRSSHSPWHLACHPHGTQMANIICAIDPLCDIYVARVAEDAFGITAKRVEKAIKWAIDKEVDIISMSFTIGEMGNIPELLNEASKKGIVMTCSTHDEGDKTQNAYPAGLKSDDRSLFVLVGCDEYGRPIRDIESDKFHYLIRGQRMAAGTIPFLKSKDTVDGSSVSTALAAGLCSLTLTCDRLQNRDIEYEAGWGKNSRYDRVNTVLKSMTSASNDKFILLNRFGRLNEENGIPSADRLLGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DPT5</accession>
    <accession>A0A0E0SBM7</accession>
    <name>A0A098DPT5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T24841</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DPT5"/>
    <dbReference type="EnsemblFungi" id="CEF83840">
        <property type="protein sequence ID" value="CEF83840"/>
        <property type="gene ID" value="FGRRES_15429"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24841"/>
    <dbReference type="InParanoid" id="A0A098DPT5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF83840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="86" mass="10157" checksum="7A3EE54D711DD21F" modified="2015-01-07" version="1">MAVQVVGRLFFQLVWYQFRYESWPTRNSLELYVPSSVEYGVFNGRIPYCMAECYIVMFGFASRDEYKANAIVEERREPAKPSKPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DRL6</accession>
    <accession>A0A0E0SC44</accession>
    <name>A0A098DRL6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG09207.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T27663</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DRL6"/>
    <dbReference type="EnsemblFungi" id="CEF84007">
        <property type="protein sequence ID" value="CEF84007"/>
        <property type="gene ID" value="FGRRES_09207_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27663"/>
    <dbReference type="eggNOG" id="ENOG502SM97">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DRL6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046676">
        <property type="entry name" value="DUF6546"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20183">
        <property type="entry name" value="DUF6546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6546" evidence="1">
        <location>
            <begin position="164"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF84007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="383" mass="43725" checksum="4D33A075BBAF2F93" modified="2015-01-07" version="1">MNGFEKLFKTLSTWEPCDDHLVLDISVYSPTDNQHWFKYLDFRPDNDLDDQETAILDDPAHGWVAGQNNSDAGILPTTALFDDIMCDKPFGSWWLSLPLVPVVGAVLLRQQTRRRWNQLALANMLTRFPNMKELCYEPWRHNLAGVADQQDIGNQQLIESFRSTKLCKLTIFENFTEEYPEAGIVFPAIRALDPDVSRKLVRSSLHLTTLSASFIVDASHFFAECQDSWVWKNLTSLTLTSRALTESTSPSDINGMLHAAAAAAFKMPKLDTMELWNGRRGVAMLFRYQRAQNWQPAIITLRGTSVLALDDPTVVRAWDNVAYQHSHGTVKFVQDSIDSNKIRSHADAIRLLGLSTDVVRPVSLQQILREHRLRRTGHRRDWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DUH5</accession>
    <accession>A0A0E0SDK0</accession>
    <name>A0A098DUH5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG09605.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T26689</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DUH5"/>
    <dbReference type="STRING" id="229533.A0A098DUH5"/>
    <dbReference type="EnsemblFungi" id="CEF84513">
        <property type="protein sequence ID" value="CEF84513"/>
        <property type="gene ID" value="FGRRES_17243"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26689"/>
    <dbReference type="eggNOG" id="ENOG502RQ3J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DUH5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="862"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="969"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="883"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="969"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF84513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="991" mass="110030" checksum="B5486B62986F33E2" modified="2015-01-07" version="1">MDSKTRLSVDSINPGSGSSALRRLTRSPSHRISLRRFSIDSASSSASSVVSYDSEASSSCVTRDTSSDDCALHRFIVWAAVKRNACDKLTPQEKLECPMLRCRKRFPNHELMLQHLYSCSWLSSSEYWCYDCGKSERFNDSKCKRCLGHPSRRRKILSMAKSFFNSLGHKSKHPTLSDFDLDLDLVDPEAPPSYDLAVAPNELELPSNEIHEIGSSGLALHPIIENEHEHEAEPDLAPMPTPFISSLPIPSRALPNHPAELESDAASGEPFDFIFPPGTVHPVSLTDTGCNTALARPTLQLHTSGLEDYRREQKRRSKGQVAPSTSVRSTASTNSTSSTNTTDTTFSKESFNISPISAYSDQWASAPVFDSDFRSSENDFGNPGGLLRANSFAISRKAPAAKDWESLDKKADSPYDSHLRECPTDFPMLGALPSGNTFHDPLALVQLVFTLNDSSLPTDFDLESNLTLTNNHAVMSPSMASTLPQPTASSYHNPRSLIDTIWRTLKLHVADSMSKLDHITKNPLVTQLKSLSAETIAANGLQILVDIIEGRQPTVPVDILCFVHLGYCFSLIAHEQDATNRSAELFGQAMSYSALFSREDIRLYIQVVKALWKPAAMTDADVVNIVRAKTSVSRSSSLKGKEHEYSNIHDSDADSLAFAAKYFLDQLELATLNVVDDAVIHTSQLYMEHFTMGVHLDSHQVAAASLILKENFQFYTHYGHFATALNHLIQRVNSDFISARRLELHLIEIGKMYLPPHVYFDGYIRHVRKQMSTLYFKNATGRNLRSAYYCHGIELIKTIMIPPLQPMNAQSIQDNGLPDSVMEYAFDDEDLGFFNNSTAPETFDFSENLPFDAGQPFDYMSLPNSALNPQPLPTPADTSSVQATPTAANSPPTPATAASSASTAKIKSDIGCTLCNYTPKGDPRWFSCSLSKHMRLQHSTKPPIIYRCQYPGCTSQYKNRPDNLRQHQIEKGHFPDGQDVGKRSNKRRKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DV20</accession>
    <accession>A0A0E0SFI9</accession>
    <name>A0A098DV20_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T27905</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DV20"/>
    <dbReference type="EnsemblFungi" id="CEF85202">
        <property type="protein sequence ID" value="CEF85202"/>
        <property type="gene ID" value="FGRRES_20405"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27905"/>
    <dbReference type="InParanoid" id="A0A098DV20"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF85202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="72" mass="7783" checksum="C8B8379A1D9D4548" modified="2015-01-07" version="1">MILIAMIKVSDIRSLDLVEHAINSVPANGSPSGRNGEAFTCRTWVKDALVALHDSGAIVLPTDIVWDALFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DVG4</accession>
    <accession>A0A0E0SHH3</accession>
    <name>A0A098DVG4_GIBZE</name>
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        <submittedName>
            <fullName evidence="4">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="primary">FG05500.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T18069</name>
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    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF85886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DVG4"/>
    <dbReference type="STRING" id="229533.A0A098DVG4"/>
    <dbReference type="EnsemblFungi" id="CEF85886">
        <property type="protein sequence ID" value="CEF85886"/>
        <property type="gene ID" value="FGRRES_05500_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18069"/>
    <dbReference type="eggNOG" id="ENOG502QYB8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DVG4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032922">
        <property type="entry name" value="SON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528:SF1">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
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            <begin position="605"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
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            <begin position="639"/>
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        </location>
    </feature>
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            <begin position="816"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="885"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF85886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="900" mass="100173" checksum="69865CF8A253469C" modified="2015-01-07" version="1">MASTITEAQAELIRSLAPDEIPIKLRCAICSKLAVNAYRLPCCEQAICESCQSNLPASCPVCEHSPLSAEDCNPNKSLRTTIRVFLRTAEKKREASRPKEDKDSEPPAPIEAPKQSLPTRETPAAEIAPEQNPGADAPSGQIDSAENVDESAATQPAHQAINSQDDTPTVEAPGHDEAGDVQNVSAGGSAEEAGVENSDKQTLTKQDVTEEPNREGKKEENQQEGDGEDEEDQEKPDSESTNGNFPNGSFSGSGDFNQMQMMMAMQNGMTPNSFGNFPMMGMPGMGMDPMTMQNMYMNGGFQGMGMNGMGGFGGGFGQGSNNNWNGSQSWNFDQNNYNQNGPGMGTGDFGGFNSGFQTGYNQGNYGQFNDYRRNNFGRGRGRGRGYYGGYGRGGYQFGGNANYQDQTQFSQHGSGQYGQNSIDSDGQQVDENGQPIQKDGTEGADEARTSNAVQADGSSEATGNEVSGDVSSMTPNMGPGASAVRPVPVPDVPLNAPTGPKAMRQGLPNTSLHHLRARGYQVGSEVPPGKSTPSARDSPAERGRSRSNSLAPSRAGTDAREKDKDHESQREHSKDRSRDHDKHDRERDDHGQNQVHAGSASRTVSRSRSRSRGHKSSRRRRRYRSESIEDDSYDDDSRRKKHRSRRHHHDEEDSSRSKDKDKDKDDRYADRNRSTSPTESKRSSHRSRRDRDSDKRKDKDDHRSDDRKKSGHRSSHRDKDYDRERRRDKDRDRSDKDRKDRKDRHRDRDRRDRDRDRDKDRDRESHRDRDRERDSRYSSRHQSTDAGTASNDKDPKPPSGPRGNETKANSQSRTESSGKDPHTLEREARDRERLLKEAQRIAGMTGWKRNRGDDGDDTGSRKGRRTASSTSARRSEAINGGDEEERMRRLEAEREGDRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DVJ0</accession>
    <accession>A0A0E0SG01</accession>
    <name>A0A098DVJ0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T23379</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DVJ0"/>
    <dbReference type="EnsemblFungi" id="CEF85364">
        <property type="protein sequence ID" value="CEF85364"/>
        <property type="gene ID" value="FGRRES_15393"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23379"/>
    <dbReference type="InParanoid" id="A0A098DVJ0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF85364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="93" mass="10433" checksum="342B8328AFE1B3C5" modified="2015-01-07" version="1">MAQTSTLNTTRRTNKAQIDISFPDASHICTSTWAHTRTRNTSLDPSSHHFSPDMDSDLCPCVWTCAGAYAFERPHVHLEDGPLFSYGHSHARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DVZ3</accession>
    <accession>A0A0E0SF25</accession>
    <name>A0A098DVZ3_GIBZE</name>
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        <recommendedName>
            <fullName evidence="8">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FGRAMPH1_01T23103</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DVZ3"/>
    <dbReference type="FunCoup" id="A0A098DVZ3">
        <property type="interactions" value="1227"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A098DVZ3"/>
    <dbReference type="EnsemblFungi" id="CEF85038">
        <property type="protein sequence ID" value="CEF85038"/>
        <property type="gene ID" value="FGRRES_06754_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23103"/>
    <dbReference type="eggNOG" id="KOG0964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DVZ3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03272">
        <property type="entry name" value="ABC_SMC3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.50.300:FF:000424">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041741">
        <property type="entry name" value="SMC3_ABC_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="11">
        <location>
            <begin position="522"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="291"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="837"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="399"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="780"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="974"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00968"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF85038.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85038"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1183" mass="134737" checksum="A12F501F62001C9A" modified="2015-01-07" version="1">MYIKQIIIQGFKSYKDQTVIEPFSSKTNVIVGRNGSGKSNFFAAIRFVLSDAYTQMSREERQGLLHEGSGSAVMSAYVEIIFDNSDDRFPTGNKEVILRRTIGLKKDEYSVDRKVVTKADVMNLLEAAGFSRSNPYYIVPQGRVTALTNMKESDRLNLLKEVAGTQVYETRRAESLKIMNETNNKREKIDELLVYIKERLNELEEEKEELRGFQDKDRERRCLEYAYYHNIQLNVQSALEELDNARQDGIDSSDTNRAEFSQGEKAISRLDSEIHKLEREMELLQIDRRQLEEDRRDSAKSMAKAEMKTKNLKEGQSAQEQARAQHAADLESVQNEIASKEQQLSVILPAYNEKKQEEDNVRRQLDHAESTRNRLFAKQSRGSQFRNKSERDAWLKKEIQELELNISTQKANKIDADEEVQRVHESIAQAEQEVAELRNRLANFSAERGALEEEATKAGDVIDKLNDERKLVRREDDKLNSVIANARQEKEAAERELSHTMDGATARGLATIRRLKQERDIPGAYGTLAELLQVSDAYRLPVEQIAGASLFHYIVDNADTATYLADTLYRQQGGRVTFMPLAQLRPKSINLPRSNDAVPLLSKISYDEAYEKAFQQVFGKVVVCPNLTVASQYARSHGVDGITAEGDTTNKRGAMTGGYIDPRKSRLQAVQAVNKWRGEYERLLAQSRDIRQQTELKDQEITAAMSELQKARERLRQAVDGFEPLRHELMNKSTHLENERGHLDAAVKRRDAVESNMNSFLEDLAGHETELKSDFKKNLTSAEEHQLEELGNSIQELQKEWNELSRARRDLGRQKQLLEVDLRQNLQMKLDQLNSQAFENSTSGSSAGGLKEAQRELKKAQKAQKTVEASLQEVEAKLDDSQARLEQLENDRAQREQAQQEISARIEKQQKRMDKSLRRKAVLTTQAAECAQTIRDLGVSSKIKRVNDALKKYKHVNKKAFEQYNNFTTQQDQLMKRRKELDESQESIEELVEHLDRRKDEAIERTFKQVSREFTTIFGKLVPAGHGRLLIQRRADRRQEPTDESDGEARGAVENYTGVGISVSFNSKHLDEQQKIQQLSGGQKSLCALCLIFALQATESSPMVIFDEVDANLDAQYRTAVAALLDSISNEIGTQFICTTFRPEIVHVADRCYGVTFRNKTSSIDCVSTEQALDFVEGQAKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DZ08</accession>
    <accession>A0A0E0SKX8</accession>
    <name>A0A098DZ08_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FGRAMPH1_01T19595</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DZ08"/>
    <dbReference type="FunCoup" id="A0A098DZ08">
        <property type="interactions" value="448"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF87091">
        <property type="protein sequence ID" value="CEF87091"/>
        <property type="gene ID" value="FGRRES_16611_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19595"/>
    <dbReference type="eggNOG" id="KOG2765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DZ08"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025016">
        <property type="entry name" value="DUF3955"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13127">
        <property type="entry name" value="DUF3955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3955" evidence="9">
        <location>
            <begin position="58"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF87091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="441" mass="49203" checksum="8A8A98983F3F80B0" modified="2015-01-07" version="1">MAPAMPAFSDEESHTRERQHGHDTDDVAVPSSPLLESRSRSPVGLRARLGLSGVARRTVGFALLLLTVFLWTMYNFIASYIFSDETYNKPFFVVYLNTSVFAISLIPKFFNYLRKNGLRGLRHDANQVWIDYKHGTNYTTSLDRSEDEQATERLIAQGYGSTEAAPLNEKLSFKDTAVLSFEFCMLWFLANYFSSACLEHTSVASVTILTSTSSVWTLIFCSLFGIERFSGAKIMGVAASLAGVILISTVDLAEQADENRGSFPRKSSTQIALGDAMALLSAVIYGLYVTVMKRKVPNEDKVDMQMFFGLVGVFNVVLLWPLFFILHWTGIEPFELPPSSTIWGIIIFNAVSSFISDISWALALLMTTPLVVTVGLSLTIPLSLIGEILQYQQYSSFTYWVGAAVVFVSFIVVSRESHDEEDLRKENDLERSVGVEQVYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098E5G0</accession>
    <accession>A0A0E0SQQ0</accession>
    <name>A0A098E5G0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG05270.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T17501</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
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                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
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    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
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    <dbReference type="EnsemblFungi" id="CEF88763">
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        <property type="gene ID" value="FGRRES_16466"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="TRIAD_supradom"/>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF216"/>
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    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF88763"/>
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    </evidence>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RUB0</accession>
    <name>A0A0E0RUB0_GIBZE</name>
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        <submittedName>
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        <name evidence="4" type="primary">FG02526.1</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>PH-1</strain>
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    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
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                <consortium name="EnsemblFungi"/>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="591"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF74835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="851" mass="95783" checksum="1526F6FA69FE3E35" modified="2016-04-13" version="1">MYASRTVCSRCSTQLRSTPAPASAKRLGAAVSYSTAPDTWTPASSAQRPNNTRRDSRTHHPGQRKGVNAFNETRQPDEDPALALFKEVVCPREENDIPPGKAYVRTSVTTPTPTLNELEITESIKNIMSGGLPVAKMYRVFQHEIWPSIRALEGHIPKSVYSAALQLLAKQREYMVLEGDYHGSVDVAEKYKALGNFDPSIRNELIINICCRALLVKNGSKERSEIRGEIFNLWRHVSQLKRPSEFGKMLRFALPSEAEVMRDTEYIKTDGSMSQGAQATRALASIFLQLPPPQAQEIIPALLATISFASDKRHAGASYSIKLSPLFLLVKPVLSKYKMTKADVKDALSKPSAIPPARFAELKEYVVEQWPAALGMIKETRQATNKFHHDPEAQRHLFNFHKQLKKAYKARDPGGVSSIWHAMTAKLQENPAFKAELAEDPAFLDFWVFVWCAVRRPARVQETVNLMKLLKLEPTIRTYTSMMHGWKMCKDIAKIEMLWDQLIKSGTKLDSVIWTERVSALIELGHHQKGLEALSELLDNWRQAVKKGTQDQAVEPSIETVNAAFKGLLHADPKAAHELLAWAGKQGIEPNTRTYNILIRETIRMGLHDEIHQLLRSMQAHNIEPDSATFTILLETVIGSMHDASAEEQVRAIKSVFSDIEQAGLKPNLETYGKMLYALDGLPNCSDDVIAALQKHMRESGFGSYLTPHMITILIERVLRHDPPDMNKIRSLLEKNNLKTVSSGDQTLWERVMTAYAISGDIKEAMYVFDNLAASGRPVTSLPCLTELIQALLERGDRAAAQRVVNIVVEYKLNNKDDKAANQRYWKHHFWYMAQHNGLVDGQKLRQYARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RWF0</accession>
    <name>A0A0E0RWF0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG10207.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T07543</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RWF0"/>
    <dbReference type="STRING" id="229533.A0A0E0RWF0"/>
    <dbReference type="EnsemblFungi" id="CEF75575">
        <property type="protein sequence ID" value="CEF75575"/>
        <property type="gene ID" value="FGRRES_17329"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07543"/>
    <dbReference type="eggNOG" id="KOG0137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0RWF0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052904">
        <property type="entry name" value="Acyl-CoA_dehydrogenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707:SF2">
        <property type="entry name" value="ACD11 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="6">
        <location>
            <begin position="192"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="5">
        <location>
            <begin position="434"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF75575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="638" mass="70382" checksum="FD925402AF400D12" modified="2016-04-13" version="1">MEASGADKGFFQKPPVLKNQFYDDVAFQRCFKLFLPKHIIRQVEAEVTALGDDVLSDEVFSWITDAERNKPYLKGSGRDVFGQWKGDLVTGEGWRGLQNFGLSRGFVAAGYDTEYGPFARAYQFLRIQLWTPSCANVGCPSAMQDGAARLLQTHLMSPELSKRLTDTQRRVFENAFQHLTSRDASYAWTSGQWMTERTGGSDVSLTETTAIHQPISDLGLASKIEDIPLGPWSISGFKWFSSATDSRMTVLLARTSKGGLSTFIAPMYKHDPHALTATGQSKENGENLNGVRIQRLKNKSGTQSLPTAELVLEDMRAWLVGQEGHGIQEIANVLTLTRVHSSVSAVGYLGRGLAIARAYARVREVGAGRGARMKLTESSLHMRTLSKISCEYRGLMLLSMFTSHVLGVSEHGVSSTSSLSPALETLTPSKQHAAPLVRVVTQLTKAYICKASVQLLFSCMESLGGVGYLANEEQEYLNIARLHRDCAVLPIWEGTTDVLSTDFLRALKHTKGGREALDALEDFVRRGITSQGKIPQPQGWDPLEAWKELRQRIESESLTDLMGDAREVLWGVADILVSILLFIDAGSDGDQVSSDIFLRFLETKNVVTKREKVSAKEQLMRDIGVVYGSTASDMSPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RXI2</accession>
    <name>A0A0E0RXI2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG10517.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T08305</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
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                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
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                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
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            <dbReference type="DOI" id="10.1038/nature08850"/>
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    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>PH-1</strain>
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        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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                <consortium name="EnsemblFungi"/>
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        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
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            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
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                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>PH-1</strain>
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    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
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                <consortium name="EnsemblFungi"/>
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            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09073"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF76706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="459" mass="50659" checksum="F502469052BD8FCD" modified="2016-04-13" version="1">MPKRKRGEPNLGEKLEKHCNDVSKALKAAKGLERQRYSKRLHEDGVESDKKERLEREVTVLKSLDLHQTARAHLYSSILKVKDLAASPNLPQEIRTGVPKPELTPEEQAALHNVTSGLYNRELVKQAVTRAITTFCEALNVPLPGKAKRVRKSKKEEKEEQPSDRIEEEPKPEVKKDVRASVEKEEEEAGAESEFEGFSDHDDDPPQEPEDVDSEDAADEEKALSKYDHLLGGSSDSEDEDDFNHERYAQFKGKEQVNLDDISDGGSDAALGLGSGSESEEESDEEEKLSISASPSPPPAKKKKSKEKAETARPRASTFLPTLMGGYISGSESASDVDVAPAKKRLGQKQRQAIWEKKFGNKAKHLQKPAWESKNGRDAGWDGKRGAVEAGDGPRTPWKKGIRNPLAAKQGGAESRPEVKRPPPKKDDEGVLHPSWAARKQAKDAEKTAAFAGSKITFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SBM6</accession>
    <name>A0A0E0SBM6_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
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        <name evidence="3" type="primary">FG07170.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T24135</name>
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    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SBM6"/>
    <dbReference type="STRING" id="229533.A0A0E0SBM6"/>
    <dbReference type="EnsemblFungi" id="CEF83839">
        <property type="protein sequence ID" value="CEF83839"/>
        <property type="gene ID" value="FGRRES_16791"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24135"/>
    <dbReference type="InParanoid" id="A0A0E0SBM6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="558"/>
        </location>
    </feature>
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        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
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        <location>
            <begin position="307"/>
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        </location>
    </feature>
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        <location>
            <begin position="404"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="464"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF83839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="558" mass="60933" checksum="3D79D8041DEB1473" modified="2016-04-13" version="1">MDNLEGMLMVPPERGQILGRAVWKLRYVVVGRRNARLGLGQSQSISNGRNNSLGGGRSFPKLPIEEACILIYKHKEDTEPIQQWPINSITDCQVQQINHRKQGPVLPTLVISIADKEKKRRSSRAAGLISSSKEANATTLWFRTPPDDHHLSLHEWARNILSRKSPMSPDSPMSPQFSNPFASMSRETSEFFSRPSSGNQSGRSDLRSLQHKSSTTTQSTATTTTTTRERPLTISSESPSLRSKRSDVSSPSSNNFPIQQMNFPIPGQHYTTVLPTDLPSPVTTAGDYQGEFIEGWTSAQGRSSTMSSPIRGRSSIGSQPPHPSIATVESSSPPGPRETILDRAFQMRCIPGSEREVPGEEKLSSLARFDALMREADDKIKQRERAERAQQMAMRSAFEASESSSDEDDSDSDDSDEDAYGGLPDRRGPALIPSTTQRALQFIADRGGPAPLSPSARSSVSRAPILQQSPPMRPHTAHAKTRPSPTQRTNSTPQLIANMARLEVTTSAKGLDDSSVRSSGDKRMSSSSTATKRRTLVGGVPGEAARSTSSTRPFHVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YHQ4</accession>
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        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
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        <name evidence="3" type="ORF">FGRAMPH1_01T01843</name>
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    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YHQ4"/>
    <dbReference type="STRING" id="229533.A0A1C3YHQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01843"/>
    <dbReference type="eggNOG" id="ENOG502QRXF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YHQ4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF11">
        <property type="entry name" value="TINC (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008687523" evidence="2">
        <location>
            <begin position="26"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB64113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="875" mass="97622" checksum="241B805935310D57" modified="2016-11-02" version="1">MFTFRSHGLLVGLVILVALASPAVAFGAGNIASISKVEGQNWRHGDITDALLILSQAQALNGKKFNKINVSRVYFGNWLRDYSQAIDVGTVKSVSAEAIRLLLCVLGFMTFGYGSGEFEVTAERLGCYRPEDHIDNPKDYAENVDARQYDERLRGPIDEERELSIDPETGMKNYIANERARIMTSAKHIKKLFSGTIELARRYKDSRRKADKYEALRLMGTGLHCLEDFFAHSNYCELALIELGERDVFPHVGRDTQIEIEGAREPVYPVVTGTFGGVDFLHSVTGEVSDKLTQNEIEELEGTLQQGANSDTSMLRDLLDKIPDGIFGDKHQSDRVDELQNSAAAAQMENTTVSPRDPEEFTQYIQNVFKQVMPAIEFHDDIMKGISTAMERIPVLPKIIEQLEEQLSVFIFSIIAPFIVPLIQQIRNELKTGSDEIIASSEREQHIVFNDDRSTDPTHSMLSKDHFSNILNEIAGRNAASMVQWVVPQLMDAIDDDGTDVDRLLDDIVDGVLHHPAQRDLGSRKAQEGRNRFFKGIEEWWQEMGDGQREEYRGKLTRDGVQNGENHKEGVQDTGHGHGCAGKLKMRKLYGGGPETLEDKIAGAAADAIFKGATGALSGMVEQNTGYKMPSSSQKEEKEEGGLSGFLNQASSLLGGAFGDKDTERQSSSRREDDGSYTRTEVEYGRHGDRYGQAEYSETQRPDGSERQEYRRYEQKDSSDGRHTGGYGYEERTETHQSYSGGYEQRTERTEYYGSNEESHSRRRDDDNSGYGGRRQDEGGYGGGSSYGRQEQSSYGGGYGGGSGGYERREESSYSSHERRQEGGDSYGRRDDNGYGGGSADDYIRQSQGSYGRERRGSRGSNEYGDNGYGGDRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YIH1</accession>
    <name>A0A1C3YIH1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T04027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YIH1"/>
    <dbReference type="STRING" id="229533.A0A1C3YIH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04027"/>
    <dbReference type="eggNOG" id="ENOG502SK62">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YIH1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="381" mass="43944" checksum="6BF8021420F401E3" modified="2016-11-02" version="1">MIETEIMTDKTELDSSLLDLPLPQLTKTTITSEYWASQHQAQRLNSVDVDLQSFWTYYNKECVRALHNGGRYVALRSHRDVVDCIHKLKSGMLRHDIKEELREKLTAPHDNEDEMLDNSIDLAASLLLMMSFCSFAYGFSGRSHLRWSHGSLESFVAAYFDPGTAHLAKENVKMEKIFTARNLCRIAGLDVVWTDNLVDHLRLTDDDRRVHVFHHASFLHVQQQSAESLLPKGLAEETLQTLALLFPSSDTETRKWFSQLSEAGLDKRAIQCGQLKTDHRQTERFRFWNDRLVVLKQVFDEAQPKSLSQWWYDRRNGVQWYCSLIANVPNTDCHPLIPVVKRYTFWVAVLVLVLTIFFGLVQSVEGALQVYASFKGLHESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YIR8</accession>
    <name>A0A1C3YIR8_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit RPB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FGRAMPH1_01T03561</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YIR8"/>
    <dbReference type="FunCoup" id="A0A1C3YIR8">
        <property type="interactions" value="998"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YIR8"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03561"/>
    <dbReference type="eggNOG" id="KOG1522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YIR8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="8">
        <location>
            <begin position="29"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SCB64246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="340" mass="37623" checksum="FA4F601E7C174022" modified="2016-11-02" version="1">MDGMDYDPMVMDGEPEQPQVKISAADHMHVDFELSKTNLSFANAVRRVIQAEVPTIAIDLVEIETNSSVLADEFIAHRLGLIPLDSKGVAELNYSRDCDCEQYCEQCSVTLTLHAKCTSDEIMKVYARDLVVDGRHGNSVGSPMIMDPEGYGCLIAKLRKHQELKISCIAKKGIAKEHAKWMPTSAVGFEYDPHNKLNHIDWWFENDTDPAVEWPKSKYAQWEDAPQEGEPFDYDAVPNRFYFEVESSGSMEPDQIVREGIRVLQQKIGGLLKGLDPRKYGGDEADFDGPRSPDMNMEGGTTPWQDGGYTTPYGGGGGQTAYGGGGMTAYGTTPYGGSWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJ54</accession>
    <name>A0A1C3YJ54_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FGRAMPH1_01T05505</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJ54"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05505"/>
    <dbReference type="eggNOG" id="ENOG502SMJ2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJ54"/>
    <dbReference type="PHI-base" id="PHI:1866"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF3">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="56"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="191"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SCB64400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="684" mass="75916" checksum="CB11157A04ECA343" modified="2016-11-02" version="1">MDSIPRKAQQDKRRRQQRKACDICRRRKVRCDIVDRTSGPCSVCEKSGLECRSKWTDERRSSVLSRHSLNDREASHSPGISHPDPDPGAVQSRNTDTDTHHSIIGPNQTSSQRRKEKASNVPQPDGQEKLAREGLARFFKHGIGAAAWAVFASTKSFRIAYVGTAVSNLVHLVDLHKSFKQPYTSILGEISGPTGPDTHGSFADSAADGSSTSDRTGGGKQLHYPYPPIRQAHSWKPTPSSWGMSQDLVTEVSSFPAQEVRDALVTAYFEHIHPFLPIVSKPEFLARYSTPDNPPPLLLFQSVLMAGAHACSHPLVANDRHAVQNILFRRASMLYHMRHESDRMHLLQAAALFTWHIGDGDTVAGGPWYWAGIAVRIGTGLGAHRKSSQLPAAEMAQYRRCWWSAFFCEVFSALETGRPCAVRAEDIDQIPLRQEDMADTATTDPSMVETPGVNPDFLNHLVDLAYIGLDVIALNAPARDRMIDISSIDARLGLWSLRSGISTVAEDDDSWTCHLRMHYNLLLLHLHRNLPSPSSSSICSAAAQAIVTSLEKLSARDELCQCHFTSVSAVTAAGIQFAGEIRTAVTSQTFLVAINALERLSRLLRCTILLARHWPNAEAVHSVLEELHREYETLVSQRLQGEQVMVPESPPDWNRLLGAEGVHQFNSFTSDQDWMNINSWTDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJE6</accession>
    <name>A0A1C3YJE6_GIBZE</name>
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        <submittedName>
            <fullName evidence="10">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FGRAMPH1_01T07055</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07055"/>
    <dbReference type="eggNOG" id="ENOG502STC4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJE6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF30">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SCB64535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="934" mass="102858" checksum="1B1298DC03CA7208" modified="2016-11-02" version="1">MNTEDEPIDPRSESRSTDLTSKSPSVHSYVTSLNYQTHTPSHINPHDPSGSSKSSSVIDLSSPTTADLNMNNRRRRSNMSIDSNDTHYAAQHASSSNTLMRPLTTAASGESRVRLTPITGKISKAKKGVLVHNCDQCPKTFSRAEHLSHSPPELYCPIPGCNKTFYRKDLLDRHVQRHDQDALDIVETERPHDQGSSKTQVLSPAETTRPEPITVFNDPQTLVSAKNSSNVAGAWQPMTSVPNINRNYKTEPSSNGSVDYPDYALDPELPAVNNNFMSNYGAPRTMPILPTLPEGVTPELHWQGSSGSTSAFSTPPNNSRSTQFPVPVANEPWMTPASTYHSTPNDIPSTSMDHVTYPAPYVYHSTPPQVYTPAFGMDLSLPGYPEDTALSTVGQTLNSTVRSVSPSLAVAQSETLLAVPSLPTSGGTFDLASCSSGTSGGNGLLSTQDLMPLSLSSATSEAIPRYLEVYWNQVHPKEPIIHKHTYQDVPEEETEHIHVLQCAMAALATQFIPNADDRMKGAELHAYALHKSKVFTRFERWSMPVQHTIALCEYYARFRGKNSYSHQPSTRFTSLYNRVVSDQLTSTSRPSIKDEHQAWKAWIAAESRRRLLAACFLLDVHSSWYHERQYTSVIGLDYSSPSTLPIPLTATTTKAWEARDPQSWSKLRTRRAPKSISNTNLWTLSASDIASGPAFDAAVLLAVYSLSLPRRQSPSQISLVEDVAKFKSNMFPISRIFPDSAIASTYLALHHTPLYHLLSVSGKTWVFNKKLTNLNLFAEHQKLLDTWRSSGTASIATVFAARSLKLFLNLQTSPSQAESSRGETCPVGTIPLSGISDYWGIYVCSLICWAFGLTEEQDKPRIGTTQDAAKEWVLRVASQEPSEVHTQSDRNGARGVVGLARQMLSTECLGGGNKLFFDAINVLIRLEGEVTSNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJR4</accession>
    <name>A0A1C3YJR4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T18337</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJR4"/>
    <dbReference type="FunCoup" id="A0A1C3YJR4">
        <property type="interactions" value="478"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YJR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18337"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJR4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000282">
        <property type="entry name" value="Glyoxylate reductase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="48"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="122"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SCB64789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="334" mass="36555" checksum="3509102B8DCBDE12" modified="2016-11-02" version="1">MTNKPKVLFLGNTKQAQEEFDSLSEIVEVIWPKSTDRAGFLEESKSGAFDGIEAIYRTNKTYSTAGMFDAELLDNLPKTLKFICHNGAGYDQIHVPECTSRGIRVSNTPTAVDDATADITIFLLIGALRNLSSSIFTLRDGTWRGSPAPLLGHDPQGKVLGILGMGGIGRNVARKARAFGMIVKYYNRSRLAPELEGEAEYVDFETLLKESDVLSLNLPLNPKTRHTIAKPQFDMMKHGVVIVNTARGAVMDEAALVDALESGQVASAGLDVFENEPEIHPGLVSNKNVLLVPHMGTWTVETERAMAAWAFDNIRLALTEGKLKSIVPEQNDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-03-27" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKQ5</accession>
    <name>A0A1C3YKQ5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T21401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB65013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKQ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21401"/>
    <dbReference type="eggNOG" id="ENOG502S3D3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YKQ5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd22893">
        <property type="entry name" value="PlcA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049756">
        <property type="entry name" value="PlcA-like_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SCB65013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1017" mass="112457" checksum="9B4C66CF40E5B010" modified="2016-11-02" version="1">MSLPDISAFTKEQLSGLFKSPYTYKEAKESTGLAENEPIDNLQDEEVVDNSLDDDRFFEAAEHESVVFGVKLRNIHCVEIPATDHETWSVQASDGTWGIFKKKKEVRLTFGRIIALAGDFYSTHADDNRTPVCGAFFAESPSLSTPEGWNAAVSRFKSAVQSLKDDTDRNLISVGDLIEQEKKGTDEAEKEIKKGENKGDLHTIANAYHDHGCGIPTNKAWIEATIGFNNPKSSLYAWLSYINADHFGDDALTAYKVGHSEAMRLAKEAGAKTSDTDKANGLQDAYMHEAFSLHYLTDAFSSGHIRAPRRQIHNDNYDEQSIAATSAITSKETPIWDFQANYMHDNDSDTGLLVQNQLGQQWLCYGDKQFKESWDIVNRARIKNCVQASVDELFQDAFTNQNVKTPADFNAVKHIPVPMLAAGKGPSTGWKSQWGGYDIHNPAPLWQVNSEDDKTAWTIRANVNDHSVFARKPGTLKNTSTSSWNPFSVDASKECYAARDSDFRTIGSAPLARPIDGLVSGGFIQIQDLAPGGTWLQTCVNFWGPVVVGIHDRQGNVEDKNTFTLRNRIVDFDSYEERSTVQPLQCIKRHGKDGLVIYRLMQHQNGDKKTLTLSGWRVKDPLASAGKDQATFTPDQSWAFKTTNLFKDLSVSELSTSPTLVRVLTGNFKAGAGTNLAILKFDINNPVQISLVANDGKPKSNTTATDTKGVYNFVKTLKNGDSDRVLLASFEKGDSDTAKMALDVMDITGDAPTVTKHQATISASLQSSKIILVGDLRKTGNDQIVALFDSQDNLTIIVNEYATNGINETTQKRVPQTLSGFPLIRPFFSALVPSEDRASPNSLSILQVSLHEYNKKPHFIFRLTDTVSWTTKTSTPVEDRLASDPHYFHLKWIRCSRQSDFDLNTSNAALEVFSFYGVLGIRLFAPISEKKLENYQEIGMLQYMGQTSIGTGLGCEGDWGSGILTWGAEKNDFVDFEAFKPDDSGSAGKGIWGMSATDAERPLVKGWDVEARPGYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKX4</accession>
    <name>A0A1C3YKX4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T22577</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKX4"/>
    <dbReference type="STRING" id="229533.A0A1C3YKX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22577"/>
    <dbReference type="eggNOG" id="KOG1184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YKX4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02002">
        <property type="entry name" value="TPP_BFDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006203">
        <property type="entry name" value="PRK08327.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF164">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="6">
        <location>
            <begin position="83"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="4">
        <location>
            <begin position="286"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="5">
        <location>
            <begin position="496"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SCB65073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="665" mass="71390" checksum="FB44E0581F6391EE" modified="2016-11-02" version="1">MTLLQRSRLAASGLSRCRPGQLQSSVRRYQSVAATSVISQRDGRNTSLSLSATPKASTAIHNVSPTAVMARPYSTASEDMYTASFAFFEAIWDAGITHCFVNLGTDHPSIIEAMVKGQREKKGKFPKIITCPNEMVAMSMADGYARLTGKPQCVIVHVDVGTQGLGAAVHNASTGRAPVLVFAGLSPFTQEGEHRGSRTEYIHWIQDVPDQKQIVSQYCRYTGEIKTGANVKQMVNRALQFATSDPQGPVYLCSAREILEADLKPYSLKQEHWEPVELGGLPTSAVDKIANALAGAKAPLLVTGYSGRNHKVPAALVELADKVKGLRVLDTGGCDMCFPADHPAWVGLAFGVHEAVTTADTIIVLDCDVPWVQTRCKPREDAKIFHIDVDPLKQQMPTHYIQADARYKADALASVEQITRALDKKEFSSKLQSNEAKAAEKERAEIHETKLATIAKGAEPLADGSFGTGHLSKKLKDLCPEDTIWAIEAVTNTGFVHDNVQPTIPGSWINCGGGGLGWSGGGALGIKLATDAENGGTNKGKFVVQIVGDGTYLFTVPGSVYWISRRYKIPVLTIVLNNKGWNAPRRSLLLVHPDGLGSKATNEEINISFDPVPDYAGIAKAAAGGDIHAARVDKASDLESVLKEAIAKVQAGQTAVVDCKVAPDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLH6</accession>
    <name>A0A1C3YLH6_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein kinase C-like</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">FGRAMPH1_01T26573</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="26">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="25 26" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YLH6"/>
    <dbReference type="FunCoup" id="A0A1C3YLH6">
        <property type="interactions" value="411"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YLH6"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26573"/>
    <dbReference type="eggNOG" id="KOG0694">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YLH6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="entry name" value="C1_ScPKC1-like_rpt1"/>
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        <property type="entry name" value="C1_ScPKC1-like_rpt2"/>
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    <dbReference type="CDD" id="cd08689">
        <property type="entry name" value="C2_fungal_Pkc1p"/>
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        <property type="entry name" value="HR1_PKC-like_2_fungi"/>
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        <property type="entry name" value="Protein kinase C"/>
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        <property type="entry name" value="Protein kinase C"/>
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        <property type="entry name" value="Protein kinase C"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="AGC-kinase_C"/>
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        <property type="entry name" value="C1-like_sf"/>
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        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
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    </dbReference>
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    <keyword evidence="16 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
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    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="22">
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            <begin position="1086"/>
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        <location>
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            <end position="118"/>
        </location>
    </feature>
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    </feature>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SCB65395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1151" mass="127251" checksum="758597D3238095A7" modified="2016-11-02" version="1">MNDDDAIHNIHKKIEREKALINAANSMRAQTNNEAVRSRLDSQMRDGRRNLQFFEEKLRDIQLRRVNQGVGDMSLGGPADDAGGPPAPPPKDASSNPAGDRGSYGSGSGQYSQAGGGSDLMPPRHPYAPGPGGSGIPKARPNFTKLDLIKYDTPHLGPRIQLMLSQIQFKLNVEEQYLKGIEKMVQLYSMEGDRKSKADAAARKVESKQKILLLKQALKRYEELHIDADVADAQDDDSINAPNLRKPLSGQLSIRMIAIKDVDHAATGRFTRGPETFIAVKVEDTVMARTKASRNDRWEAEFHTIEVDKANEIELTVYDKPGEHPMPIGMLWVRISDIVEEIRRKRIEAEMNSSGWVSADRMGSTSAAPTQFPMSPSSGSFGPGAQSTGGDQGDDTGPFGAAGPQPQVQTGPIEEWFNLEPTGQIQLQLTFNKSNNNSRPADLGLGRKGAVRQRKEEVHEMYGHKFVQHQFYNIMRCALCGDFLKYSAGMQCEDCKYTCHTKCYSSVVTKCISKSNAETDPDEEKINHRIPHRFNPYSNMTANWCCHCGYILPFGKKNCRKCSECGLTAHAQCVHLVPDFCGMSMAVANQILDGIRTQKQRQAKVSSLSEKTLRHGKTSPTSTSSPAPSYSSTTAPSYQSGPVSPEATEAAKMMYSNPSTPRPAGPDRTSSSSQAAAAASAAMSGGPGAAQRQNSDFGRYSGGYDQPQEDPYAQGGQYGAGQQRKYNPADYANVNPGYGGPQPAAQAQRPVQQQPAQQPPPQSPLPPVPQHQQQQPQAAYQQPAVPAHSPQQPEPMSPKQQSAAGGKSAPLATDPGTGQRIGLDHFNFLAVLGKGNFGKVMLAETKRSRKLYAIKVLKKEFIIENDEVESIRSEKRVFLVANRGRHPFLTNLHACFQTETRVYFVMEYVSGGDLMLHIQRGQFGTKRAQFYAAEVCLALKYFHENGVIYRDLKLDNILLSLDGHVKIGDYGLCKEDMWYGSTTGTFCGTPEFMAPEILLDKKYGRAVDWWAFGVLIYQMLLQQSPFRGEDEDEIYDAILADEPLYPIHMPRDSVSILQKLLTREPDQRLGSGPTDAQEVMSQPFFRNINWDEMYHKRVPPPFMPQIKSATDTSNFDSEFTSVTPVLTPVQSVLSQAMQEEFRGFSYTADFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLI3</accession>
    <name>A0A1C3YLI3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T25047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
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            <location evidence="1">Nucleus</location>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10933"/>
    <dbReference type="eggNOG" id="ENOG502SK3B">
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        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </evidence>
    <sequence length="808" mass="90318" checksum="62B0813299102A6E" modified="2016-11-02" version="1">MHHPSGSGRAIVKPQVTDMNHQNIQSPNTGNGSTTADTEVPSCQGCRRRKLRCSRDKPTCNHCQRLDAPCIYDLKKNKPGVKTGVIEGLSRRVASEALENTVYQGSNANNSNPSVDSSQLIGAFSSLIQELRGLVSSAGVTLPLQTINSALAQTQHATPGTASLSSPNDVHQQPRKRRRVDSCGNPNIELASQLGELGSTTSQLPPPELLEEVINAYFILVQPWIPILHETRFRSRFYNHEQLPCLTVLLHAIVVAAIRFVDLGSDKISEKETEIWTSKSRSIVILSGMDAFTDMGNGDIARAWPIIGSLTRTVEYLQLSVEFDDRQQGPLLKPLTSLPPAQNWAQEEERRRVFWSIFNLDRLCSVMTGWNTSLTSDDVRRRLPADGGLWHKVETVLTPYFGIWDRSAAKMGNSIVFLPAHYPSPEQVTEAPTETPSTNTTASKRNDTVDMTTVGAFAYCIEATESLSRVTTYFLQQRINFKDRQEVGNWLTRFKELDLRLVHWKMFLPQKWKDSNISRRPTIINMDPNLTLAHITHNTSMILLHQQIAYPAPQWTSIVRMPSAHSAETCQIAAAETATITQKYLKYTAENSPVNSQFAFCVFVSARALLVHWRYYKTVLASEFWVLIDSLDHFAKRWAGPICEAKSKTSLAGKYSAQLRALYQKCTENPEYSPDVVGYSTDGFVDHISTQTPQGHEFTRNNIRSEGTGAVGALNTTFDTRPTNTGLPFDPTHTQISNDQLNFLPQISPTNPGLEHNSPDELSAISTVLMDQDFMQLDRVISFDDMMFTAQTIDDQGAPFPMDNWTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMM3</accession>
    <name>A0A1C3YMM3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T12293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YMM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12293"/>
    <dbReference type="InParanoid" id="A0A1C3YMM3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008687658" evidence="2">
        <location>
            <begin position="17"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB65765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="319" mass="35247" checksum="ED48E8388713D74A" modified="2016-11-02" version="1">MGVFVILLLALQDVLLFPIAAFPRYVTAPAVIICRSFLPAKTKPRVTKWPFLFEDLLSKTRNHDEKLLAAVLRDDSIIERVARHLHYDDIVNLSLTSKLMRTAIFHPSIETSHRQSRVESLCVSSCVDGQKSECWGCDRVICAECTDQRSDIIPSRVKGHFANCYAVCTYCYLMSAPGGGAPFQAKRNMQDLELQHINCYRSNITAMREARDEFYLSKTLPSYPPQPPQPPPPSPSPSPSPEASVTQPLPQVSPAIPGLPTAHPAPAAPHTNTPTPQPPAPEWSAFVAPTSIFAALQSLNFSYSAIRSGKVYMDQFATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMX0</accession>
    <name>A0A1C3YMX0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T13429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13429"/>
    <dbReference type="eggNOG" id="ENOG502RS7E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YMX0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="907"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="937"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="971"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1167"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1239"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1408"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1504"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1542"/>
            <end position="1552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB65837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1645" mass="181107" checksum="C85D42EA40094D3A" modified="2016-11-02" version="1">MSADPDDEVIDLTSSPDADAISTDSLPRIPNSLSRRYRQGGATFTANRHGVFEPTTKRRKTDILTNSHKKARLESTRKSIHYDAVYQHQRAVKKHIIVRRHAKFYILQCDQHDISFDDNPFLNSKKHLREDHGITATGHDTVIKHFGVEVIECDDTKLEQNNAVAEKALQDGTNALAKDAIKVTDSSNLPKSPQAKRNCPERPTLKLKSNSSRNTTRSNRRKTQNDEDVPLDLVPGNVYIIWWFETQQWFAGLLMPHQNLEAVGIHKPLEQLAIFKTMPACYQYDTSSKSLSWAKDFEDGGPKASERYYPFIFFEGFQFPEKCHQAWIQLDNIRPWDDEKSAYIEHRAKAVRFLKEQRERKKRKSKAPITEAETPESIDNHEPSQNAGSRDSDCDENSDMYEFRGSSPLAESSTDNQAVPESNIATPDTINDPETVAELGQKEATPDFENDDAMILEQLDGSDQEMVDADQDMDEPPQSEVPELSVQQERVPKDPDPDQTIQTSEPPTQSDGEMDLITIEDTTESEQEHTQSVDDTLEEPEVATTAEVATTAEVLHNGNDEAQTDIHMTEPSDNNPTTREPSQGKIGTTTEIQNDIIEETQPANIPGTDRQSVAESEHDDASQQSDQAHPNEKPQPTSRQRPDQNRWMDDDIRRIINGPSPDRAIIEGVSSEIDSTTQPILVQKPAAINEQASTPAPGQDIDLDSLLAEGENLELHMSQTEPATQQHVESYQTSPTSSDDNRLANDLFNAIMSEDRQLSTPRSSPHMNHSNPDTLQPRAEDTDMGQQNSVSSPQASEERSQPSPYAQMGAPASLHSRPASKSSNLRQPSYDETGTPASVIRQLSATRNATRHHSNDGMGRRMSVSSRPSTRNSDISQQHRDAETGQPTPTAGGSNEEFHSRDPPSIYQITSSQPRSLSRGLDLRPQANETAMRESPVMSQPDTRTTSGATPVQMPLRGPETDQNPPERPTNWLQQVVASPPQSHAGGSPSNSMPFETQATAPSQQSTNVSIQENSVPQYSDTAPLPEMDSSQSLPTSDQYQTSVDQSSYQPAIADPQPIRETRAFSPSQLPSATQQSARDILRVLAESEESGQLPRHNAPLPPSGDHPSPDASSNSLGQQDSSATFRTPTMGNSHAFQEAMPSPRQPVMQHPLVPYHKPSAPQVMPSPRLSNASISRSSSLSQGYTVPPHQPLPSPYQLAGELPRPVSNTQNFRTQPSPQQPAMELQRAQTATYVQPRPNTTVSTPYTTTSLPPPSTLAQGPPMLQVSASPRLQAMEISRPSSAVQDSRTPTSPRQYAMRFAQPVSTVHGAPLDTALSPRMVLGGPSRPGSFVQGQSSTVNASPQLATREISRPSSAMYGQRTLPAMPSPRQAPIVMHQSMLSTHGRVHQPLSTSSPQLPAAQLPRYNSVSYSQSGPPAMTSPRQSTVSGSQPGLVTPPLPALASPHILGATAPPPMTVQGMQAPEPTHTSSRPGQPIEPPRPISQSSSNGPLPPLQPRGSNYIPASQTHRSHSPPAQTRNDTMGHPRRHSRQSSQSYSYRGNPQTSNSTPRSHAPAYQVPVQRPNPAQHSSTLHDYLPRHVVEALIEQTGRSGNDLKPCSFLNYQTMYECPFCRAGMPEQAVFVRHLQRLCPYIKYINDKRPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RBC9</accession>
    <name>I1RBC9_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG00845.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T02115</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316565.1">
        <property type="nucleotide sequence ID" value="XM_011318263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RBC9"/>
    <dbReference type="FunCoup" id="I1RBC9">
        <property type="interactions" value="1303"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RBC9"/>
    <dbReference type="EnsemblFungi" id="CEF72857">
        <property type="protein sequence ID" value="CEF72857"/>
        <property type="gene ID" value="FGRRES_00845"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00845"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02115"/>
    <dbReference type="eggNOG" id="KOG1678">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080796_0_0_1"/>
    <dbReference type="InParanoid" id="I1RBC9"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF72857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="203" mass="24018" checksum="88A28177326450BE" modified="2012-06-13" version="1">MGALKYVEELQKKKQSDVVAFLLRVRCWELRQLNVIHRASRPSRLDKARRLGYKAKQGYVIYRVRVRRGGRKRPAPKGATYGKPTNQGINQLKYQRSLKATAEERVGRRCANLRVLNSYWINQDSTYKYYEVILVDPQHKAIRIDPRINWIVNPVHKHREARGLTATGKKSRGLNKGHRYNKTKAGRRKTWKRHNTLSLWRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>I1RC05</accession>
    <name>I1RC05_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">FG01104.1</name>
        <name evidence="18" type="ORF">FGRAMPH1_01T02753</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="19">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="19">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316867.1">
        <property type="nucleotide sequence ID" value="XM_011318565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RC05"/>
    <dbReference type="FunCoup" id="I1RC05">
        <property type="interactions" value="1044"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RC05"/>
    <dbReference type="EnsemblFungi" id="CEF73178">
        <property type="protein sequence ID" value="CEF73178"/>
        <property type="gene ID" value="FGRRES_01104"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01104"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02753"/>
    <dbReference type="eggNOG" id="KOG2784">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025086_2_0_1"/>
    <dbReference type="InParanoid" id="I1RC05"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2320:FF:000001">
        <property type="entry name" value="phenylalanine--tRNA ligase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2330:FF:000002">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000028">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="17">
        <location>
            <begin position="230"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CEF73178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="511" mass="57891" checksum="B6998D626E537E48" modified="2012-06-13" version="1">MTTSSSAPSGDLTSQILQALSEKTPLLSSEVFPTIAFQDIKASLDRLASRSMITYETIDKEEAILEPEAEQIAEHGSHEARVFEALRNAVEGLSIQDLEKAIGDKTVTKVGQGKAFKEKWIKKSDDGKLVATAKSIEDITRAQLQKIKETRTHEPKVLTDLRKRKLIKMQKVISFKIEKGPKFALEITKEETDLTADMIASGSWKSANFKPYNFKALGADQNAGALHPLNKVRHEFRSIFFEMGFEEMPTNKFVETGFWNFDALFVPQQHPARDLQDTFYISDPAVGDAPRSEEGQNTEEYWENIKQVHQDGKFGSIGYRYPWSAEETKRLVLRTHTTAISTAMLYKLAAQKGPDGRPPPARYFSIDRVFRNETVDATHLAEFHQVEGVIADYDLTLGGLMEFMEAFFAKMGITNLKFKPAYNPYTEPSMEIFSYHEGLGKLVEIGNSGMFRPEMLEPMGLPKDMRVFGWGLSLERPTMIKYKISNIRELLGHKVDLNFIERNPAVRLEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>I1RCC5</accession>
    <name>I1RCC5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG01230.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T03045</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transport of phosphate groups from the cytosol to the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317005.1">
        <property type="nucleotide sequence ID" value="XM_011318703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RCC5"/>
    <dbReference type="FunCoup" id="I1RCC5">
        <property type="interactions" value="815"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RCC5"/>
    <dbReference type="EnsemblFungi" id="CEF73324">
        <property type="protein sequence ID" value="CEF73324"/>
        <property type="gene ID" value="FGRRES_01230"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01230"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03045"/>
    <dbReference type="eggNOG" id="KOG0767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039456_2_1_1"/>
    <dbReference type="InParanoid" id="I1RCC5"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035434">
        <property type="term" value="P:copper ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000076">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000131">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="79"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="176"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="277"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF73324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="378" mass="41055" checksum="C632F38C3F85A3D5" modified="2012-06-13" version="1">MSPLHPSKDALQGMFYSSLSATNHTPYQARAELFPIHSSVVEDAKGKAKKLSAEATAEFEKASAKAQAKTGKIELYSGRYYTACTFGGLMACGLTHAAVTPLDLVKTRRQVDSKLYTSNFQAWGKIYRGEGIRGIFTGWSPTLFGYSAQGAFKYGWYEYFKKTYSDMAGPEAATKYKTGLYLAASASAEFLADLALCPFEAVKVRMQGSIPNPYTGTVQGIGAITGKEGVAGLYKGLYPLWGRQIPYTMMKFASFETIVEMIYDRLPGQKSDYSKAAQTGVSFTGGYLAGILCAIVSHPADVMVSKLNSNRQPGEAFGSAMGRIYKDIGFGGLWNGLPVRIVMIGTLTGLQWMIYDYFKIFMGLPTTGGGPPPAKKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RCV3</accession>
    <name>I1RCV3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG01435.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T03529</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317240.1">
        <property type="nucleotide sequence ID" value="XM_011318938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RCV3"/>
    <dbReference type="FunCoup" id="I1RCV3">
        <property type="interactions" value="270"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RCV3"/>
    <dbReference type="EnsemblFungi" id="CEF73570">
        <property type="protein sequence ID" value="CEF73570"/>
        <property type="gene ID" value="FGRRES_01435_M"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01435"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03529"/>
    <dbReference type="eggNOG" id="KOG3385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086133_1_0_1"/>
    <dbReference type="InParanoid" id="I1RCV3"/>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000057">
        <property type="entry name" value="SNARE complex subunit (Bet1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="84"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF73570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="174" mass="19163" checksum="D2527F4AE6256621" modified="2012-06-13" version="1">MAQRFGASSLHQRDSRSALFEGYNGDAASRRPVSASPNRGYGYGGYGAPSPSPLGHGGFDSSRPAPFRSATPNKRGQYSDAVLNELESQNDAQVEGILGKVKVLKDMTVAIGDEIRESSALAEKMNDTFDSTRLRLRGTMNRMLVMAQRTGVGWKVWLIFFAAVIMLFMYVWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1RDK0</accession>
    <accession>A0A098D5Y8</accession>
    <name>I1RDK0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG01701.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T04139</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LovG family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317531.1">
        <property type="nucleotide sequence ID" value="XM_011319229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RDK0"/>
    <dbReference type="EnsemblFungi" id="CEF73877">
        <property type="protein sequence ID" value="CEF73877"/>
        <property type="gene ID" value="FGRRES_01701"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01701"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04139"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_0_2_1"/>
    <dbReference type="InParanoid" id="I1RDK0"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF3">
        <property type="entry name" value="ESTERASE DBAE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF73877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="265" mass="29572" checksum="470ACBD3E57F8C3F" modified="2012-06-13" version="1">MTQAEAHNDADTLHLPRILCLHGGGVNAEVFELQCRVLIRHLSSSLRLVFMQAPFISAPHPDIVSVYGEYGPFRRWLRWQPDHEEIEPEAAADLIRNETRRAMETDPGTGEWVGILGFSQGAKIAASLLWTQQQITEKFGPDEALTQFKFGVLIAGRAPLITLDHRLKHPPPIVHAALLSSEFTDWPESNKGEHVLSIPTLHVHGLRDAGMEQHRILLNNYCETGTTTLIEWDGGHRIPIKSHDVGAVVHEMLRLAKDAGVQLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1REV6</accession>
    <accession>A0A098D688</accession>
    <name>I1REV6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG02210.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T05329</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318103.1">
        <property type="nucleotide sequence ID" value="XM_011319801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1REV6"/>
    <dbReference type="STRING" id="229533.I1REV6"/>
    <dbReference type="EnsemblFungi" id="CEF74469">
        <property type="protein sequence ID" value="CEF74469"/>
        <property type="gene ID" value="FGRRES_02210"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02210"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05329"/>
    <dbReference type="eggNOG" id="KOG1014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_17_0_1"/>
    <dbReference type="InParanoid" id="I1REV6"/>
    <dbReference type="OrthoDB" id="5399006at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="SDR_fam"/>
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    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
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        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="248" mass="26773" checksum="31AF96672DE911E8" modified="2012-06-13" version="1">MASKSLYAIIAGVGPGTGRSVALRFAQKYPVVLFARRPESYESTVADVEKAGGKAIGITADVADPASLKKAFDDINKQFPNSHLAAAVYNVGSGGFAKKPFLEQTKKDLDASIDGSIRSFFHFAQATIPHLLEAVPESHYPPTLILTGATASIKGSPQFSTFAAGKWGQRAMHQSLAREFGPKGVHIAHAIIDGVIDIPRTKEWAANDGADDGKISPDAIAEAYWNLHTQHRSAFTQEIDIRPYVEKW</sequence>
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    <accession>I1RF02</accession>
    <name>I1RF02_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="4" type="primary">FG02263.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T05461</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318167.1">
        <property type="nucleotide sequence ID" value="XM_011319865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RF02"/>
    <dbReference type="STRING" id="229533.I1RF02"/>
    <dbReference type="EnsemblFungi" id="CEF74535">
        <property type="protein sequence ID" value="CEF74535"/>
        <property type="gene ID" value="FGRRES_02263"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02263"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05461"/>
    <dbReference type="eggNOG" id="ENOG502SDBY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026974_5_1_1"/>
    <dbReference type="InParanoid" id="I1RF02"/>
    <dbReference type="OrthoDB" id="124329at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30006:SF2">
        <property type="entry name" value="ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30006">
        <property type="entry name" value="THIAMINE-BINDING PERIPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13343">
        <property type="entry name" value="SBP_bac_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124103" evidence="2">
        <location>
            <begin position="18"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="366" mass="41017" checksum="A1DDA5CAB18BBEAD" modified="2012-06-13" version="1">MRTSLLSLASLATSAWGYDQVLGFNTKVETETRSLDEIHKAALKEGGVVTLWHGGDSVNRQSGLKAAFEKRFPGMELNVTVDLSKYHDARVDQQLATGGKAVYVDSVILQTLQDYPRWAQQGALLNYAPKGFDQIQDAYKDTTASWYGVYIFGWGFGWNSNKLPGIKAPAEYPDFLRPEFKNKLVLTYPNDDDAVLYAYQLIMQQYGVSWFQDLLKQNPRWVRGTATPSAMVKASNYTQAAYFAAGAGFQNAEPMHFGHPKSGKYVTWPQTAGILKDAPHPEGAKLLHNFILSPEYQKAVGTWSVRRDMPIPAGYPDIANETATNPAEFLRWMSDRTTVERLRFWIEAHIGTAQGVDPIYEAINMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1RF30</accession>
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        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318202.1">
        <property type="nucleotide sequence ID" value="XM_011319900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RF30"/>
    <dbReference type="EnsemblFungi" id="CEF74571">
        <property type="protein sequence ID" value="CEF74571"/>
        <property type="gene ID" value="FGRRES_02294"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02294"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05533"/>
    <dbReference type="eggNOG" id="ENOG502SU5G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059039_1_0_1"/>
    <dbReference type="InParanoid" id="I1RF30"/>
    <dbReference type="OrthoDB" id="5429716at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF74571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="296" mass="31862" checksum="C9C0157279731967" modified="2012-06-13" version="1">MPTATEFWGFNAHNLGPLTTTFTAPSSCATGTDHHVFVNASEPVRIFGVPTCGPMTFGDCIPSASSWESIHEQTTEFVQGQYAYFSPGLACPSGWSTVGTLAHGGDGDNKASASGALESPDWDEFMHPNYLHPTEFWLGLLEPSETLAYCCPRRCVSTIGPTESYTYSEMCLTYNRDKMLPVSTWDGTTLTDDRLVSFASATDEPMTTLDDILLTGTAVEKYWAIATYVPAVQLVYKESDKDDSKDDEKEDDDKDEEDSNDGSGDDNAASAITPRSGVVSVLGITLGLLAGAGILL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-08-30" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I1RF60</accession>
    <name>AURJ_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">O-methyltransferase aurJ</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aurofusarin biosynthesis cluster protein J</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gibberella pigment protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aurJ</name>
        <name evidence="8" type="synonym">GIP7</name>
        <name type="ORF">FG02326</name>
        <name type="ORF">FGRAMPH1_01T05597</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1701" last="1708">
            <title>Putative polyketide synthase and laccase genes for biosynthesis of aurofusarin in Gibberella zeae.</title>
            <authorList>
                <person name="Kim J.E."/>
                <person name="Han K.H."/>
                <person name="Jin J."/>
                <person name="Kim H."/>
                <person name="Kim J.C."/>
                <person name="Yun S.H."/>
                <person name="Lee Y.W."/>
            </authorList>
            <dbReference type="PubMed" id="15811992"/>
            <dbReference type="DOI" id="10.1128/AEM.71.4.1701-1708.2005"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="Fungal Genet. Biol." volume="42" first="420" last="433">
            <title>Identification of a gene cluster responsible for the biosynthesis of aurofusarin in the Fusarium graminearum species complex.</title>
            <authorList>
                <person name="Malz S."/>
                <person name="Grell M.N."/>
                <person name="Thrane C."/>
                <person name="Maier F.J."/>
                <person name="Rosager P."/>
                <person name="Felk A."/>
                <person name="Albertsen K.S."/>
                <person name="Salomon S."/>
                <person name="Bohn L."/>
                <person name="Schafer W."/>
                <person name="Giese H."/>
            </authorList>
            <dbReference type="PubMed" id="15809006"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2005.01.010"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2006" name="Mol. Microbiol." volume="61" first="1069" last="1080">
            <title>The biosynthetic pathway for aurofusarin in Fusarium graminearum reveals a close link between the naphthoquinones and naphthopyrones.</title>
            <authorList>
                <person name="Frandsen R.J."/>
                <person name="Nielsen N.J."/>
                <person name="Maolanon N."/>
                <person name="Sorensen J.C."/>
                <person name="Olsson S."/>
                <person name="Nielsen J."/>
                <person name="Giese H."/>
            </authorList>
            <dbReference type="PubMed" id="16879655"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2006.05295.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2006" name="Appl. Environ. Microbiol." volume="72" first="1645" last="1652">
            <title>GIP2, a putative transcription factor that regulates the aurofusarin biosynthetic gene cluster in Gibberella zeae.</title>
            <authorList>
                <person name="Kim J.E."/>
                <person name="Jin J."/>
                <person name="Kim H."/>
                <person name="Kim J.C."/>
                <person name="Yun S.H."/>
                <person name="Lee Y.W."/>
            </authorList>
            <dbReference type="PubMed" id="16461721"/>
            <dbReference type="DOI" id="10.1128/AEM.72.2.1645-1652.2006"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2011" name="J. Biol. Chem." volume="286" first="10419" last="10428">
            <title>Two novel classes of enzymes are required for the biosynthesis of aurofusarin in Fusarium graminearum.</title>
            <authorList>
                <person name="Frandsen R.J."/>
                <person name="Schuett C."/>
                <person name="Lund B.W."/>
                <person name="Staerk D."/>
                <person name="Nielsen J."/>
                <person name="Olsson S."/>
                <person name="Giese H."/>
            </authorList>
            <dbReference type="PubMed" id="21296881"/>
            <dbReference type="DOI" id="10.1074/jbc.M110.179853"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2013" name="Microb. Cell Fact." volume="12" first="31" last="31">
            <title>Reconstruction of the biosynthetic pathway for the core fungal polyketide scaffold rubrofusarin in Saccharomyces cerevisiae.</title>
            <authorList>
                <person name="Rugbjerg P."/>
                <person name="Naesby M."/>
                <person name="Mortensen U.H."/>
                <person name="Frandsen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="23557488"/>
            <dbReference type="DOI" id="10.1186/1475-2859-12-31"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3 5 6 7">O-methyltransferase; part of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15809006, PubMed:15811992, PubMed:16879655). The first step is performed by the polyketide synthase which condenses one acetyl-CoA and 6 malonyl-CoA units to form the first intermediate, the cyclic heptaketide and yellow pigment YWA1 (PubMed:21296881, PubMed:23557488). The C2 hydroxyl group in the pyrone ring of YWA1 is probably formed during ring closure by an aldol-type cyclization reaction (PubMed:21296881). The dehydratase aurZ then acts as the first tailoring enzyme in the aurofusarin biosynthetic pathway by converting YWA1 to nor-rubrofusarin (PubMed:21296881, PubMed:23557488). Nor-rubrofusarin is then methylated to rubrofusarin by the O-methyltransferase aurJ (PubMed:21296881, PubMed:23557488). Rubrofusarin is then transported across the plasma membrane by the rubrofusarin-specific pump aurT for further enzymatic processing by the extracellular complex composed of GIP1, aurF, aurO and aurS to yield aurofusarin (PubMed:21296881).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>norrubrofusarin + S-adenosyl-L-methionine = rubrofusarin + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:145839"/>
            <dbReference type="ChEBI" id="CHEBI:145894"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:62685"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5 7">Pigment biosynthesis.</text>
    </comment>
    <comment type="induction">
        <text evidence="4 5">Expression is regulated by the aurofusarin biosynthesis cluster-specific transcription factor aurR1/GIP2 (PubMed:16461721, PubMed:16879655).</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318235.1">
        <property type="nucleotide sequence ID" value="XM_011319933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RF60"/>
    <dbReference type="SMR" id="I1RF60"/>
    <dbReference type="STRING" id="229533.I1RF60"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T05597">
        <property type="protein sequence ID" value="FGRAMPH1_01T05597-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G05597"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02326"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05597"/>
    <dbReference type="eggNOG" id="ENOG502SIYN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_1_4_1"/>
    <dbReference type="InParanoid" id="I1RF60"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="BioCyc" id="MetaCyc:MONOMER-19449"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF19">
        <property type="entry name" value="DUAL O-METHYLTRANSFERASE_FAD-DEPENDENT MONOOXYGENASE ELCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000441088" description="O-methyltransferase aurJ">
        <location>
            <begin position="1"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="15809006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="15811992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16461721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="16879655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="21296881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="23557488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="16461721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="9">
        <source>
            <dbReference type="PubMed" id="16879655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="10">
        <source>
            <dbReference type="PubMed" id="23557488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="11"/>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74603"/>
        </source>
    </evidence>
    <sequence length="439" mass="48089" checksum="F4C18EEAE425AE18" modified="2012-06-13" version="1">MGSISSPSLIIDLANAVSSAAKNLDTQLQSQGFPQPSFEADGPTYVVPKDAPKAAHEARVATAEAALKLFNLVSGPSELLPNMTASYHTIFALQWLHHFDVFSHIPLDGSLSYEKLATKANVPESLLKSVARMAMTSNILAEPTTGQVAHSANSAMFVKFPNMRDWASYMFTASIPTAAAMVQATEKWPGSVKKTETAYNIAFNHDLPFFDHLSQSPVMTKQFSGYMRSVTDGQGMDLSHLVNGFDWASLPDKSLIVDIGGSAGHASYALAAAYPHLRFEVQDLDTVVNGEKAAKEHEEAVSKHVIGTDNRVTFKAHNFFEAQPTKDATVYMLRMIIHDWPDAEAKTILGNLVPALESAKATLLIMDTVLPSPGSIPSVRERVIRTRDLTMRQVFNAKERGVDDWEAILRETDSRLTLKNLRQPEGSNMCLLTISLQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RFF8</accession>
    <name>I1RFF8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG02432.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T05839</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318353.1">
        <property type="nucleotide sequence ID" value="XM_011320051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RFF8"/>
    <dbReference type="STRING" id="229533.I1RFF8"/>
    <dbReference type="EnsemblFungi" id="CEF74724">
        <property type="protein sequence ID" value="CEF74724"/>
        <property type="gene ID" value="FGRRES_02432"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02432"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05839"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_1"/>
    <dbReference type="InParanoid" id="I1RFF8"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF1">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="5">
        <location>
            <begin position="62"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF74724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="439" mass="48130" checksum="6F8045D16046FB0B" modified="2012-06-13" version="1">MATQAAYGVEKIVGHSDNAITAQDVTSYQETGDHSQTMKALAWMGKNKVQMVDAPKPKVIEDRDVILRVTGSTVCGSDLHLLHGTVIQLSEGDILGHEFCGVVDEVGAGVTGIDVGGRYVASFQIACGDCFFCKQKLSSQCEKTNSNTTERAMYGGRTAGMFGYSHFTGGFAGGQAEYVRVPLGDVNLLKIPDDVPDEKGECLDTAVYPNDSVAVFGAGPIGQMAGIFALKEGASKVIFVDTEPRLSFVRERWPAEHKDKLELVDFKQLSHGVTNKPTVVSRLKELTGNRGPDCAIECVAGEYPKGWMHTIELAIGAETDTSEIINEMIEGVRNYGRCGVTGVYVGYTNHFNIGSLMERGIRLIGNGQAPVHKYWDELLEMIQRGELDPAQMLSHRVRLEDLDKVYYKFEKKEDGMQKVFVETKFSFPRDPSTPALTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1RGI0</accession>
    <name>I1RGI0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T11449</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322961.1">
        <property type="nucleotide sequence ID" value="XM_011324659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RGI0"/>
    <dbReference type="EnsemblFungi" id="CEF77527">
        <property type="protein sequence ID" value="CEF77527"/>
        <property type="gene ID" value="FGRRES_02846"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02846"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11449"/>
    <dbReference type="eggNOG" id="ENOG502S3YM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144283_0_0_1"/>
    <dbReference type="InParanoid" id="I1RGI0"/>
    <dbReference type="OrthoDB" id="5216128at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025363">
        <property type="entry name" value="DUF4267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14087">
        <property type="entry name" value="DUF4267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="126" mass="13717" checksum="DD580AD8D5D3FEB5" modified="2012-06-13" version="1">MNDNILHYGNQLMALVPGLIGLNLLVRPEATLQQMEFTIPSEPKARQLTRGLARVYGIRNVVIGSIGLNLSLTRDPKLINMIYLGGLAMCVTDGIVAKSVIGHGEWLHWVFAPICIAGAAANYYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I1RI58</accession>
    <name>I1RI58_GIBZE</name>
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        <recommendedName>
            <fullName evidence="7">pectin lyase</fullName>
            <ecNumber evidence="7">4.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG03483.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T12989</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.10" evidence="7"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322230.1">
        <property type="nucleotide sequence ID" value="XM_011323928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RI58"/>
    <dbReference type="SMR" id="I1RI58"/>
    <dbReference type="STRING" id="229533.I1RI58"/>
    <dbReference type="EnsemblFungi" id="CEF78298">
        <property type="protein sequence ID" value="CEF78298"/>
        <property type="gene ID" value="FGRRES_03483"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03483"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12989"/>
    <dbReference type="eggNOG" id="ENOG502QXM6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021980_0_1_1"/>
    <dbReference type="InParanoid" id="I1RI58"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047490">
        <property type="term" value="F:pectin lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000003">
        <property type="entry name" value="Pectin lyase F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF16">
        <property type="entry name" value="PECTIN LYASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124279" description="pectin lyase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="10">
        <location>
            <begin position="95"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF78298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="377" mass="39210" checksum="21AC3CA6D335A94D" modified="2012-06-13" version="1">MKSISILSVAFAALVSNVSAAGVTGTPEGFAAEATGGGNAEGAYPKSTDELVSMLGDSTTRVIFLDQEFDFTGTEGTASEQGCAPWGTGAGCQQAINKDGWCNNYQADAPKVDVTYDKAGLNPIVVNSDKSIVGIGANGVIKGKGLYIKGAKNIIIQNIHITELNPQYVWGGDAIQVDGSDLVWIDHVTTSNIGRQHIVLGTSATNRVSITNNYINGESKWSATCDGHQYWSMYFTGSSDMVTLKNNYIFKTSGRAPKVAGNTVLHAVNNYWQGNSGHAFETSDQAKILAEGNLFQDVKAAIEEGSTGAFFASSDASANAACSNGVGHVCEVNKYDNSGSLSGTDSSFFSTFGGKGASAKPASSITGLATSAGFGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJK6</accession>
    <name>I1RJK6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T14295</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321623.1">
        <property type="nucleotide sequence ID" value="XM_011323321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJK6"/>
    <dbReference type="FunCoup" id="I1RJK6">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RJK6"/>
    <dbReference type="EnsemblFungi" id="CEF78950">
        <property type="protein sequence ID" value="CEF78950"/>
        <property type="gene ID" value="FGRRES_04031"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04031"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14295"/>
    <dbReference type="eggNOG" id="ENOG502QSKI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019711_0_0_1"/>
    <dbReference type="InParanoid" id="I1RJK6"/>
    <dbReference type="OrthoDB" id="434695at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000146">
        <property type="entry name" value="Clathrin-coated vesiclec protein (Bud7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000149">
        <property type="entry name" value="Clathrin-coated vesiclec protein (Bud7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF78950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="702" mass="78889" checksum="A6314162CEAF4A71" modified="2012-06-13" version="1">MVAPAVPEITEEILHESIDARTESLAGLRELGPPDLVHLLKHGVRNPAKQTGVYHHVTGVDASSSASLAAYINTLTYKESGPNATNKIVEGVFCCYNAFSRLDMRVHVSIPGTVESYCVDERGEKRKASEDLWLETYLCSVLRAYSYADDGSGDTIRKIMGVRRFNPVTNTETEHRFLHAAEQLFFRGWQLGSDSVVQVPTNVSNHLTTGLLKYLETTGRYASGINLFEKLRTQSVEVSSLLAKVMFMGHEEVAGVRTLHQSLKENPMDYVMLDTQAEFLLGKAKNSATPELKEERLKLSLGCADRATVAAPTEFSTWARLAQVYVAMEDWDNALTILNSCPMFTYQDKDTPLMPEPKEVILPTLPETRLDEIDSEPESRYSEQVDPSLLNLRAASYRGTFKKAYEILTEMTAKIGWDQLLKIRSNVFVMEDEYRTEKQESTHPGASKRTPSTDGLRGTPDQTVNRDNEAEGENAEKPAEEVSEEEADADADAPATNGNGEQSKIETPSNVIDPGEAKTDPETTKSDENLSKLNTKRLCERWLDSLFMVLYEDLRVYTIWRTQMAQYRAQQMQYKKSAEEWEILGSLAERLQHMDEAVEAYRACLSIRFSPKALAGILRVFEKTKSTRETVASVIRLVTWQYRWYSEFSPELLHTIRTLIEDEGAVKVRSIIQATSLPQNVLDLTHHYAALCATFRSSGTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJW6</accession>
    <name>I1RJW6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG04149.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T14607</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321481.1">
        <property type="nucleotide sequence ID" value="XM_011323179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJW6"/>
    <dbReference type="FunCoup" id="I1RJW6">
        <property type="interactions" value="924"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RJW6"/>
    <dbReference type="EnsemblFungi" id="CEF79106">
        <property type="protein sequence ID" value="CEF79106"/>
        <property type="gene ID" value="FGRRES_04149"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04149"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14607"/>
    <dbReference type="eggNOG" id="KOG1790">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118652_1_1_1"/>
    <dbReference type="InParanoid" id="I1RJW6"/>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018065">
        <property type="entry name" value="Ribosomal_eL34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46595">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01145">
        <property type="entry name" value="RIBOSOMAL_L34E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF79106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="116" mass="13288" checksum="B4DA82765565C29D" modified="2012-06-13" version="1">MANMRVQYRRRNGYNTTSNRTRVIKTPGGDIRLLHIKKRGTVPKCGDCGSKLSGIPALRPREYSQISKPKKTVQRAYGGSRCGNCVRDRIVRAFLIEEQKIVKKVLKEQEQSQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1RKI0</accession>
    <name>I1RKI0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG04383.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T15155</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321223.1">
        <property type="nucleotide sequence ID" value="XM_011322921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RKI0"/>
    <dbReference type="STRING" id="229533.I1RKI0"/>
    <dbReference type="EnsemblFungi" id="CEF79378">
        <property type="protein sequence ID" value="CEF79378"/>
        <property type="gene ID" value="FGRRES_04383"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04383"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15155"/>
    <dbReference type="eggNOG" id="ENOG502RS82">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048773_0_0_1"/>
    <dbReference type="InParanoid" id="I1RKI0"/>
    <dbReference type="OrthoDB" id="5428055at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF79378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="463" mass="53284" checksum="3D09836E890F184D" modified="2012-06-13" version="1">MSRYPPAPEPRHRTTRRRSSERGLYGAYRPYLLEWNAQSCRQKDISTVEEFQEEMSLVERPGWRRIALVRGECDMGAILGMELDKKRGGWVWEFPETETRRRKSEESDNETKEKDDDSDSDQDEGIRICRASLMTRERLPILLFDGLPFRIPSRPYRPSRIPSNTVPDRSKQGKRAPKRSELEDSLWQALVDIRPIEDLVAELIYDTWLQKLDSLPPLGSDSVDVQWTIARALETNADTTRSMERRGDFCSITSTDWANLAERLQRRIQISVTVALQSHAQQAQDEPKDANARSLDRIAYLGGLLLPLTVVSGILSIESTYGPEGSSFWVFWLASGLCSIIALLVIYADHLRTLDVWIEVAASEILDLDHNKRFQANRTPRRREYHSSGDPERGEAKLTTASDGGIYVVQHRGDGTRGRTWRRKRLGWLGAMKKMSGWYAWRGSPGLEFRMPGWERKVRHLVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1RL32</accession>
    <accession>A0A098DNW6</accession>
    <name>I1RL32_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG04612.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T15703</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320965.1">
        <property type="nucleotide sequence ID" value="XM_011322663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RL32"/>
    <dbReference type="EnsemblFungi" id="CEF79651">
        <property type="protein sequence ID" value="CEF79651"/>
        <property type="gene ID" value="FGRRES_04612"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04612"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15703"/>
    <dbReference type="eggNOG" id="KOG2633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029822_0_0_1"/>
    <dbReference type="InParanoid" id="I1RL32"/>
    <dbReference type="OrthoDB" id="6077599at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF121">
        <property type="entry name" value="ADP-RIBOSE 1''-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Macro" evidence="7">
        <location>
            <begin position="104"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF79651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="606" mass="67060" checksum="5B12F4BA574595A7" modified="2012-06-13" version="1">MSQVTMIHNSPATAAMLDYTLIYVLDDMTENGPSYLSRDYNLQHYKEHMDHLETASKLALLRECLCARPPVPLLPENIMHNIELILMRVRDHKLFTPLSSLSLSQTIKHDASRHTNIHLWKGDIATLTGITAITNAANSQGLGCFQPTHRCIDNIIHTEAGPRLREECFWLMKKRSKDLEPGDLLVTGGHALHASSVIHTVGPQLKRGASPTDLERSQLAKCYKGILDAVELLPPGEDGRKSVALCCISTGLFAFPADEAAKIAVSTVTAWLESHSSTTITDVVFNTFTESDTKIYTAILGSHSTRITPPITSSAEGSLQVAQDWLGSADAILVTAGAGLSAAEGLDYHSRDLFKKHFPGFLKFGLISLYSVFGYNEWPSEEYRWGYYFTHLNMISNWSNTPTYQALIPWLKDFGSDAFVRTSNADGLFLANGWSEGQLSTPQGSYAYLQCLNNCRNDAVVPSTPLVAEALPFIDPDSQKLTDSSKIPICRFCGSEMSICVRAGSWFNQTPYKNGEAQWKAWKSRITKEKKKLVILELGVGMNTPGVLRWPNEDLVERSQGLVKLIRVGIGAEAMVPWEQEDGGLSTFIQGDIQRVVPLLLDDVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>I1RN27</accession>
    <accession>A0A098E2S5</accession>
    <name>I1RN27_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG05388.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T17787</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
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            <authorList>
                <consortium name="EnsemblFungi"/>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RNE8</accession>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the palH/RIM21 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_011325769.1"/>
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    <dbReference type="AlphaFoldDB" id="I1RNE8"/>
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    <dbReference type="EnsemblFungi" id="CEF86055">
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        <property type="gene ID" value="FGRRES_05524"/>
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    <dbReference type="KEGG" id="fgr:FGSG_05524"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18125"/>
    <dbReference type="eggNOG" id="ENOG502QWMT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014594_1_0_1"/>
    <dbReference type="InParanoid" id="I1RNE8"/>
    <dbReference type="OrthoDB" id="5393256at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="InterPro" id="IPR014844">
        <property type="entry name" value="PalH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH/RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH_RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08733">
        <property type="entry name" value="PalH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="402"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="450"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="499"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="555"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="580"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="634"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
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        <location>
            <begin position="555"/>
            <end position="570"/>
        </location>
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        <location>
            <begin position="674"/>
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        <location>
            <begin position="744"/>
            <end position="755"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="760"/>
            <end position="769"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF86055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="778" mass="84757" checksum="C791A2468CE3CAAC" modified="2012-06-13" version="1">MTAAGLISATITAPPSLCTTTLLPDTGVMTLGLDGVPTILTEPAVYQIPCPTHDILPRAEVHVTYAASGDESSLTQHELSDSSPKFSDFRDPFYASTFPICYALAATTVTAYMLVIMLFVTPRSFLDGGIVYLGRKSAFTHSSNNSVTIGGRPWLQKVAALTVAISLTIASADTFRVAKSQYTWGIQNANQLQDEVMNSVELKVIRLVSDTFLWLAQAQTLIRLFPRHREKIIIKWVAFALITLDVVFSAVTSFKYSDNGINTTARPKNFVHPVPALSYLFQLSLGLLYAAWVVYFALMKKRYSFYHPFMKNISFVAIISLISILIPVVFFILDISQPDFTGWGDYVRWVGAAAASVVVWEWVERIEALEREEKKDGILGREVFDGDDTLEINASEFPWLRNRKSRKGGSSGGGSDGDRPQMSATSANGWPTVSSIANRYRGQNNGAFAETLDQPLQRGTARGLRPVIWPTRPAPAATPISRADTASAASTVYAVRYQAPSETTSRTPDPMPLPGVVDLSQQSSTPPSQQLNDESSSSNQAPASLQNSIVVPPTSQQPVDLEANSPNSSARGGWRNLTFASSTLNRPNEDASTDVAQRSDGNVAAAREGRANSSSRWDLKGRLEDFAANQAEKLRDRMRTAPNTESLPVTVIPAPPRRGAALQQVLEEEELNTTDRQSPQSSSRHPFANHNSTTSQSSASRDASGEVGRLDRSRSTSSGSPGNGPIPPNNPPLWRGVRPRPANEDDFYDDSDDGSLSDRSSLDHPRQDSDSPGTRRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I1RNP2</accession>
    <name>I1RNP2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG05626.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T18361</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324188.1">
        <property type="nucleotide sequence ID" value="XM_011325886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RNP2"/>
    <dbReference type="EnsemblFungi" id="CEF87615">
        <property type="protein sequence ID" value="CEF87615"/>
        <property type="gene ID" value="FGRRES_05626"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05626"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18361"/>
    <dbReference type="HOGENOM" id="CLU_2171305_0_0_1"/>
    <dbReference type="InParanoid" id="I1RNP2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF87615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="110" mass="12569" checksum="AE300128690B4C0C" modified="2012-06-13" version="1">MTSLKPEVTTFQSLLEWNLAPLSLERRTAARPNMHLHLQTQRLDAETETTESTVLEKRPYLKFYDPKEAALREKIWCPLHDCLDQVDAGSVECLAQANLVLIANQGHLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RNW7</accession>
    <accession>A0A098DYF2</accession>
    <name>I1RNW7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG05710.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T18567</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324286.1">
        <property type="nucleotide sequence ID" value="XM_011325984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RNW7"/>
    <dbReference type="EnsemblFungi" id="CEF86352">
        <property type="protein sequence ID" value="CEF86352"/>
        <property type="gene ID" value="FGRRES_05710"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05710"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18567"/>
    <dbReference type="eggNOG" id="ENOG502SNXC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120086_0_0_1"/>
    <dbReference type="InParanoid" id="I1RNW7"/>
    <dbReference type="OrthoDB" id="3758478at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF86352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="158" mass="18014" checksum="E39D530851713264" modified="2012-06-13" version="1">MTCTNLRQSIERTARQFFAAYVESGEKNDPSIINRDVDENCKRYYRPLSLCDFFGVPGDWSHDNKAYEGGITNNFSRGSLKTCEVSNLTIDVDIRRAAATTKSDMVFKDGETLVMEHAWTLDFNEDGTKIVRVVEFCDQLATRKMVTKVYPDKFGKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RNX8</accession>
    <name>I1RNX8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG05723.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T18607</name>
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    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324302.1">
        <property type="nucleotide sequence ID" value="XM_011326000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RNX8"/>
    <dbReference type="STRING" id="229533.I1RNX8"/>
    <dbReference type="EnsemblFungi" id="CEF87290">
        <property type="protein sequence ID" value="CEF87290"/>
        <property type="gene ID" value="FGRRES_05723"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05723"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18607"/>
    <dbReference type="eggNOG" id="KOG1485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_10_0_1"/>
    <dbReference type="InParanoid" id="I1RNX8"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
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    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF11">
        <property type="entry name" value="CATION DIFFUSION FACILITATOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="187"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF87290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="477" mass="53464" checksum="81E801E2EE6A0F59" modified="2012-06-13" version="1">MVGKRQWNTNQGPGPRHRGQHVGEEARPQYDDGPRDLETGRYSYNGGSKDSRPKPRIMKFQDAARTALEDARRGEIKRALLHGIDRSGLEKYRKSDDELKAIKNKKLRYFYEQQNERLNDWLEVDAVVMAIADDVLESMNPDPDHDGDQERGGGIQRVEGNIGELLPDEEKEKRRKAARKANWAININVIANILLLAGKTFAVFTTGSLSLVASLVDSALDLLCTLIVWSTSRLVLWRLHAMQRRFPVGKRRLEPLGILVFSIIMVISFLQILQESVSRLMPPHAEAEVLSWTAIASLLSTIVLKGAIGLGCRPIKSTQVQALVQDCKTDVIFNTLSLLFPFIGYRANIWWLDPAGAGLLSLFIIYDWGHTCFENVARLSGEAANDHTLKKLIYLAYRFAPVVAGFKNVTAYHAGDGVWVEFDLLLDEKTPLNRSHDIAETLQYCAEGLGEVDRAFVTTDYSVSGPLGHATDSEWNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1RPJ7</accession>
    <name>I1RPJ7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG05969.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T19187</name>
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    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324582.1">
        <property type="nucleotide sequence ID" value="XM_011326280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RPJ7"/>
    <dbReference type="EnsemblFungi" id="CEF88253">
        <property type="protein sequence ID" value="CEF88253"/>
        <property type="gene ID" value="FGRRES_05969"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05969"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19187"/>
    <dbReference type="eggNOG" id="ENOG502RK0Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060983_1_0_1"/>
    <dbReference type="InParanoid" id="I1RPJ7"/>
    <dbReference type="OrthoDB" id="3012298at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GH18_CTS3_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="GH"/>
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    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
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    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
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        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="III CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03850)-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF88253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="346" mass="38725" checksum="8C771E7A63150EA7" modified="2012-06-13" version="1">MPPLPPSANPLPRLVTYYQTHHDSSGNLISTLPLITQPGIAITHVIVAAIHINEDPEKIALNDYHPSHPIFQTMWAELRILQASGVKVMGMLGGACKGSYARLDADENTFERFYCPVRDMIRERALDGLDLDVEEVMSLGGIVRLIDRLRSDFGPTFIITLAPVAMSLIDFRRNLSGFDYEALEVMRGRDIAWYNTQFYCGWGDCSNPLMYDLMVQKGWPPEKIVIGLLTNPENGHGYVPFNPLGMVLTTLRGRYGNFGGVMGWEYFNGLPGGKERPWEWAREMTELLRGHILSEPAQVTQLTQQQQPVPVESAPKKNEEVDPDTPGGKDVALPKQFDYYTDGSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I1RPL1</accession>
    <name>I1RPL1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG05984.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T19221</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324599.1">
        <property type="nucleotide sequence ID" value="XM_011326297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RPL1"/>
    <dbReference type="STRING" id="229533.I1RPL1"/>
    <dbReference type="EnsemblFungi" id="CEF86028">
        <property type="protein sequence ID" value="CEF86028"/>
        <property type="gene ID" value="FGRRES_05984"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05984"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19221"/>
    <dbReference type="eggNOG" id="KOG3299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045276_2_0_1"/>
    <dbReference type="InParanoid" id="I1RPL1"/>
    <dbReference type="OrthoDB" id="69641at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF25">
        <property type="entry name" value="PROTEIN IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Impact N-terminal" evidence="2">
        <location>
            <begin position="25"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF86028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="216" mass="24093" checksum="534A3C3CAEEA2847" modified="2012-06-13" version="1">MAAKRAAQSILPKSQPPSWTPSKRISEFIAHVSPVTCPSQASSYVDSLLESDKRIRNATHNITAWRIRGDGPGHQQFNDDGETGAGSRLLQLMQSMDLWDSMVVVTRWYGGTHLGSKRFRFITAAASDAFARAGMDGNKKEEKSKGKKRKLFIFVHRDLREKAVDPLLARLNSCDEFDWAHAVGQSGTRGQVGLTKDFPELSEHPSWMTRNLISIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1RPU2</accession>
    <name>I1RPU2_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG06072.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T19415</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324695.1">
        <property type="nucleotide sequence ID" value="XM_011326393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RPU2"/>
    <dbReference type="STRING" id="229533.I1RPU2"/>
    <dbReference type="EnsemblFungi" id="CEF87089">
        <property type="protein sequence ID" value="CEF87089"/>
        <property type="gene ID" value="FGRRES_06072"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06072"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19415"/>
    <dbReference type="eggNOG" id="KOG4034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121541_0_0_1"/>
    <dbReference type="InParanoid" id="I1RPU2"/>
    <dbReference type="OrthoDB" id="19439at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF87089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="173" mass="19873" checksum="5BA4C2C8639DAA4B" modified="2012-06-13" version="1">MRFLASRALSIGRQAFSQQPVSFTQRATLTTIKPAPARRQTFKKHVSYKPDPQEKPVNPNKNKKIPYKARPLEQPMVPLPAKDPKEVGTYLRYIIKRTPSLQLPVYRRWMSGGNRCIVVIKKVKGDHAKLVKDLSDDLDIKAENIRLNPVTQHIEIKGDLYAETMKWILKVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>I1RPU3</accession>
    <accession>A0A098E4K7</accession>
    <name>I1RPU3_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="4">eIF3e</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG06073.1</name>
        <name evidence="4" type="synonym">INT6</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T19419</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the eIF-3 subunit E family.</text>
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    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_011326394.1"/>
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    <dbReference type="AlphaFoldDB" id="I1RPU3"/>
    <dbReference type="STRING" id="229533.I1RPU3"/>
    <dbReference type="EnsemblFungi" id="CEF88572">
        <property type="protein sequence ID" value="CEF88572"/>
        <property type="gene ID" value="FGRRES_06073"/>
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    <dbReference type="KEGG" id="fgr:FGSG_06073"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19419"/>
    <dbReference type="eggNOG" id="KOG2758">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_031132_0_0_1"/>
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    <dbReference type="OrthoDB" id="417252at2759"/>
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        <property type="component" value="Chromosome 3"/>
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    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
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        <property type="entry name" value="eIF3e_N"/>
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    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21357">
        <property type="entry name" value="EIF3E_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
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        <location>
            <begin position="245"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF88572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="439" mass="49947" checksum="B98B572D2B2473EE" modified="2012-06-13" version="1">MEDVLNAVSADGSSIMPRLAPNLSRHLLFPLIQFESERAEEQGLDAKAKELLSGKIKLLEDTNMTDYVATLYCELHGVENAPEEYNKKRQEVLSQLENYEQATAKIADLLTQDEVVNGLRSDKVANLEFLKNQHGVTMEMVNALYDFGQFQFRCGQYGPAADMLYQFRVLSTDNDKVSAATWGKLASEILQTNWESAVDELKNVRENIDSKLFNNPRAQLDHRTMLLHWSLFPLFNWEGAREPILEMFFSAPFINTIQTSCPWILRYLIAAVITGRGRARNSSIQQKQIKDIIRYVRQEAYEYTDPITQFVNALYIAHDFEAAREALSMAAEVCRSDFFLASSADAFVDAARHLICESYCKIFSRMNIRDLSAKLGLNPDDGEKWIVNLIRETRLDAKIDSQDGTVIMNHPPNNVYQQVIEKTKGGFFRTQVLNAAVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQT1</accession>
    <accession>A0A098DSI3</accession>
    <name>I1RQT1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG06431.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T22265</name>
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    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326029.1">
        <property type="nucleotide sequence ID" value="XM_011327727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQT1"/>
    <dbReference type="EnsemblFungi" id="CEF84821">
        <property type="protein sequence ID" value="CEF84821"/>
        <property type="gene ID" value="FGRRES_06431"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06431"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22265"/>
    <dbReference type="eggNOG" id="ENOG502SSWZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100662_0_0_1"/>
    <dbReference type="InParanoid" id="I1RQT1"/>
    <dbReference type="OrthoDB" id="5402033at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF84821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="241" mass="27460" checksum="DD0F50E6FEDF3B60" modified="2012-06-13" version="1">MTKSKADAAKIHFIDFKDHASRPAETFWSGQKHRVLPPLPSLCFYFVHPDFNLDELDLRAFWRDVIDGLYGPFRFEMFCIPGEELKARGDIFEQVREASRAYKDPEYAAARKAQGKLPGLVTSHRYPGALVYHGLVIIYKDATWNREDEDKTFDVIKFGLALTSEDFELGDKIIVQEPLKTTQRINSALSSISGMLHFPNRPKDQAVMAQCAVSATLRRGIELTTFAQPEDPYYAITIIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1RR42</accession>
    <name>I1RR42_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T22565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22565"/>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1RRF6</accession>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
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    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
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    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
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                <consortium name="EnsemblFungi"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_011328006.1"/>
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        <property type="gene ID" value="FGRRES_06676"/>
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    </evidence>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326366.1">
        <property type="nucleotide sequence ID" value="XM_011328064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RRK1"/>
    <dbReference type="EnsemblFungi" id="CEF83158">
        <property type="protein sequence ID" value="CEF83158"/>
        <property type="gene ID" value="FGRRES_06727"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06727"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23017"/>
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    <dbReference type="InParanoid" id="I1RRK1"/>
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    <dbReference type="Proteomes" id="UP000070720">
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    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="341" mass="36603" checksum="DC6C12CB5BA53EBC" modified="2012-06-13" version="1">MATRRSAAAATSDETAMTTTPSSPKQVERPPPSFRDMVPHKAKYPLAIATSFAMASLGYSLLSELTNAELAGLSRTQETWEEVALLAGWRIVELTIGWYAQLDGLDVAMLDLLSHGPHFYLLTTFYGLNWTTAASALAVDIFSVAVPFYLLRPLSPTHTSSAAAAAGLPNRELLDLPLQSYTAAMSTGIYTVVLVLALRFVLPRILVVNYSGVDTLEPAYNASYAAILPVTTLFGIAASTFIFAPFATTARAKEDDKINEFDPVAASLGETVRWNVWGYTVKTKVVIRRTVLVAFVAAVNTFLASYKTMYRVDAIGAAAYAGVWTFAAVCSGIGLGFVGGD</sequence>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="CEF84882"/>
        <property type="gene ID" value="FGRRES_07041"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07041"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23809"/>
    <dbReference type="eggNOG" id="KOG2536">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome 4"/>
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        <property type="entry name" value="Mitochondrial glycoprotein"/>
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        <property type="entry name" value="MAM33_sf"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF84882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="290" mass="32071" checksum="9D1C296F4BD4189A" modified="2012-06-13" version="1">MFSARNVARSAPRVVSRLSGAALRQTARPSAFIKASSARRPAQAAFSTTVFRKAAENDGELLAKLESEIKIEEDMKADEQDPASIKDFLNNSAFELIDTPGQEVVKLVRNFGEEKITISFSIADITSYDPYAEENGLEEEGFEDEGAQGSQRNARANEELEEELDEEAEEENAAPINLSIVVEKPGKASGALNIDATAQDGHIVVENLFYYDDAKVAKVESPEAAQKRADVYPGPPFGSLDDDLQVLMERFLEERGITQALAIFVPDYVDVKEQREYTRWLNNVKAFIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1RSQ3</accession>
    <accession>A0A098DMS1</accession>
    <name>I1RSQ3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FGRAMPH1_01T24165</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326903.1">
        <property type="nucleotide sequence ID" value="XM_011328601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RSQ3"/>
    <dbReference type="FunCoup" id="I1RSQ3">
        <property type="interactions" value="748"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RSQ3"/>
    <dbReference type="EnsemblFungi" id="CEF83156">
        <property type="protein sequence ID" value="CEF83156"/>
        <property type="gene ID" value="FGRRES_07181_M"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07181"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24165"/>
    <dbReference type="eggNOG" id="KOG3506">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177289_1_1_1"/>
    <dbReference type="InParanoid" id="I1RSQ3"/>
    <dbReference type="OrthoDB" id="10252683at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.830.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_uS14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="RIbosomal_uS14_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_uS14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004424">
        <property type="entry name" value="PRK05766.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010:SF2">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF83156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="56" mass="6693" checksum="58932FD598C7A845" modified="2012-06-13" version="1">MSHESVWNSRPRNYGKGSRSCRVCKHKAGLIRKYDLNLCRQCFREKAKDIGFNKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1RT70</accession>
    <name>I1RT70_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T24655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327132.1">
        <property type="nucleotide sequence ID" value="XM_011328830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RT70"/>
    <dbReference type="STRING" id="229533.I1RT70"/>
    <dbReference type="KEGG" id="fgr:FGSG_07369"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24655"/>
    <dbReference type="eggNOG" id="KOG0316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_1_1"/>
    <dbReference type="InParanoid" id="I1RT70"/>
    <dbReference type="OrthoDB" id="71437at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="122"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="168"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SCB65255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="406" mass="43668" checksum="9592C1C40D117366" modified="2012-06-13" version="1">MGFPDKPSAHLLGANGNVSPFFLYSTSLSLSLRLSVSPSYPHPHPHTLPHPRRSSFQLQLHLQAWRLALSPVHALAYSASPGTYILTGSADRAIRLYNPFPSTSAPGDDRHSIPQGRLIQNYAAHGYEVLSLSVAADNERFVSAGGDRSVFLWDVSTAVTTKRFGGNAHGHTARINCVSFAGEGDSIIVSGGFDTSVRLWDTKSSSFKPIQVFDEASDAITCLAVRGPEVLAGSVDGRVRSYDIRMGQVTTDVIGAPVTSLSLTRDGRAMLVGSLDNKLRLMDRDNGSCLRAYTDPAWKNEDVKLQALLGGKEKYVMVGDAMAGEAVSKGEGRIWAWDLLTGKLAAKVTVPWGPQGFELKKKAVGRDGKEKARSNVVSCMAWREDGWGDQFCVGGTSGVVTVYGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RT73</accession>
    <name>I1RT73_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG07372.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T24659</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327135.1">
        <property type="nucleotide sequence ID" value="XM_011328833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RT73"/>
    <dbReference type="ESTHER" id="gibze-i1rt73">
        <property type="family name" value="LYsophospholipase_carboxylesterase"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF85302">
        <property type="protein sequence ID" value="CEF85302"/>
        <property type="gene ID" value="FGRRES_07372"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07372"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24659"/>
    <dbReference type="eggNOG" id="KOG2112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062889_1_0_1"/>
    <dbReference type="InParanoid" id="I1RT73"/>
    <dbReference type="OrthoDB" id="437457at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF67">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G09340)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="30"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF85302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="255" mass="27912" checksum="F24972D1970EAFAF" modified="2012-06-13" version="1">MPPRVPTEEDFSPLKSTLPHTLHFPDPPESTTTFLILFHGLGDHDVPYAGFAKNLNLPGVLGISVRGTSVLPAALMGTDVPGYHFGDDLTVDPNTGDIADDSGFEKARKLVMEKLITEVLIEKCGWEMRDIMFFGFGQGGSLALGLAAALDTTSRVTDVTEGENTTAAGNKTFKGLISLGGPLPQSMVSTVTNRRKSRTSVLVCQLDEDAVDAVKQEFDDVKVVQWKRRQLSMPIDRDEVLPLMQFFADKLRNEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I1RTK5</accession>
    <name>I1RTK5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG07514.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T24993</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327290.1">
        <property type="nucleotide sequence ID" value="XM_011328988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RTK5"/>
    <dbReference type="STRING" id="229533.I1RTK5"/>
    <dbReference type="EnsemblFungi" id="CEF84035">
        <property type="protein sequence ID" value="CEF84035"/>
        <property type="gene ID" value="FGRRES_07514"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07514"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24993"/>
    <dbReference type="eggNOG" id="ENOG502S1WE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020076_1_0_1"/>
    <dbReference type="InParanoid" id="I1RTK5"/>
    <dbReference type="OrthoDB" id="722566at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045048">
        <property type="entry name" value="FBXO31/39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706">
        <property type="entry name" value="F-BOX FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706:SF130">
        <property type="entry name" value="F-BOX ONLY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12014">
        <property type="entry name" value="Cyclin_D1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF84035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="501" mass="56480" checksum="14FE6EBB6F2E955A" modified="2012-06-13" version="1">MSISSQAPESPLSRPLSSPEIPSDTPLLLDLPPELIDNILSHLSPYDLSAISATCRDLRKHALSDILWQPLVQENVPGMTLTSPHPCSSYHDLYASHDRLWFLPRQKIWFCDRDLTGRLMLVRYDPRRGCIEGYQLLASRGRPLHQSWLGQGDVLIQEFDPKVKLHLDKPILQFRVGEEAPVDFTTRPGANRFADEMPVTLDDRIDALFSNFMLTCELDQEEAQDNLKSPFPYGNIWPPPSVPSDHHVSGGSTQITEEGIFVNTPATRPRRRRDVSERFFRVRQWMEMAGGLARIGMAAGMTGIFNMLRLSRPAAAGGLPGVHVGEELITYSTLDPKLYTPTPLKPWRGIWVGDYSTHGCEFLLVHQPDDETPATDEELGLIRGETETEGAWVARRDEGRTYQGRLEAIKLTGDPNVPRGEITFLAKDLNDLVTGPPADPRFQGMKMVHSQGHIADTGFISDRFVKSHLILVSHDRIAQHWVEFGHVSYFQRVNIDEFLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RTQ6</accession>
    <name>I1RTQ6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG07570.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T25119</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327350.1">
        <property type="nucleotide sequence ID" value="XM_011329048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RTQ6"/>
    <dbReference type="EnsemblFungi" id="CEF83744">
        <property type="protein sequence ID" value="CEF83744"/>
        <property type="gene ID" value="FGRRES_07570"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07570"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25119"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="InParanoid" id="I1RTQ6"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF281">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF83744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="334" mass="37093" checksum="45E5FD1A4ED87899" modified="2012-06-13" version="1">MQSILQKATGIGPQVIKPENLQGRVAIVTGGALGIGYEVSRALAHAGCKVIMVNRKEEQGTSAIEAVKNEKHDADIDWKECDMGNLSQIREVFGGFRESLDRLDFLVLSAGINTNQFGLDSDGIERHFGVNFLGHFYVCNQLWPLLRKTSKMENVSPPRVVFEASEMHRLAQLSNVQFKTKEEINDPDLDPTARYNRTKLAMILFAKYGLAGKVIAENKDKIYALSVHPGAVNTAMQQQWKDAYPGLTGKLLSWTMQAIGRDVEQGSYSALWALTSSRIEEENLNGYYFVDPDKEGEETSQASNPELASNLWDLSTSFIKEKLGEDALADWNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I1RVH8</accession>
    <name>I1RVH8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG08254.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T09483</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320548.1">
        <property type="nucleotide sequence ID" value="XM_011322246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RVH8"/>
    <dbReference type="ESTHER" id="gibze-q4i3f4">
        <property type="family name" value="AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF76544">
        <property type="protein sequence ID" value="CEF76544"/>
        <property type="gene ID" value="FGRRES_08254"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08254"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09483"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_49_0_1"/>
    <dbReference type="InParanoid" id="I1RVH8"/>
    <dbReference type="OrthoDB" id="294702at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763:SF46">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="304" mass="33959" checksum="D48DA9B3ED774E0B" modified="2012-06-13" version="1">MEDYQDKTVTLADGRKVAYTIYGTDNPAAPTMFYFHGFPGSHHEGYLTHSTALKHGLRVIAPSRPGYSDSTFQDNRSILDYPKDILELADLLSAQRFAVLGVSGGGPYAIACLKEIPRERLVGIGTVAGCMPLSFSTQGMLAMTRIMFNVAPYATGPLGWIVDKLLGTTARDTEHPEKLEDMMDKDMTARSPSDAEIWTNHPDLRRSLLRSTREAMKQGGYATAWEARLFGSDWGFKLEDVKVKKGEMILWHGDQDVNVPLRVSEKAVELMPQAELRVLKGESHMSLITKVDEFVVEMKEMLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>I1RW84</accession>
    <name>I1RW84_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">FG08545.1</name>
        <name evidence="17" type="ORF">FGRAMPH1_01T10223</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endosome membrane</location>
            <topology evidence="2 12">Peripheral membrane protein</topology>
            <orientation evidence="2 12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the VPS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320210.1">
        <property type="nucleotide sequence ID" value="XM_011321908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RW84"/>
    <dbReference type="FunCoup" id="I1RW84">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RW84"/>
    <dbReference type="EnsemblFungi" id="CEF76915">
        <property type="protein sequence ID" value="CEF76915"/>
        <property type="gene ID" value="FGRRES_08545"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08545"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10223"/>
    <dbReference type="eggNOG" id="KOG1818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011862_1_0_1"/>
    <dbReference type="InParanoid" id="I1RW84"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="PHI-base" id="PHI:6183"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15735">
        <property type="entry name" value="FYVE_spVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21385">
        <property type="entry name" value="GAT_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16979">
        <property type="entry name" value="VHS_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1940:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.40.10:FF:000161">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENTH_VHS"/>
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    <dbReference type="InterPro" id="IPR017073">
        <property type="entry name" value="HGS/VPS27"/>
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    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049425">
        <property type="entry name" value="Vps27_GAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21356">
        <property type="entry name" value="Vps27_GAT-like"/>
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    </dbReference>
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        <property type="entry name" value="Hrs_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0967">Endosome</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="16">
        <location>
            <begin position="26"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="15">
        <location>
            <begin position="168"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="454"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="544"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="579"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="708"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00017753"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR036956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CEF76915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="717" mass="78555" checksum="27E7AB6D465484B2" modified="2012-06-13" version="1">MMSWWSSSANTALDEQIEKATSSSLEDIALNLEISDVIRSKTVAPKEAMRSLKKRIGNKNPNTQLSALNLTDTCVKNGGSHFLAEVASREFMDNLVSLLQAVGGAAVNADVKSKILELIQSWAGATEGRYELSYIGEVYRTLQRDGYQFPPKTSVASSMIDSSAPPEWTDSDVCMRCRTPFTFTNRKHHCRNCGNCFDQQCSAKVVALPHLGIMAPVRVDDGCYAKLTNKGHKLPNPSLDRSPTYPHKTRSTSAMQPRNARVDDGFDEDLKKALAMSLEEVKTHSHGFTGPVQASHVTDGNASVAKQAEEEDDDLKAAIAASLADMEEQKKRHATALKEQTSSSVNASSSANFVLPKNDYELTPVEAENINLFATLVDRLQTQPPGTILREPQIQELYDSIGTLRPKLARTYGETMSKHDTLLDLHAKLSTVVRYYDRMLEDRLSKAYSQQSLGGYNLPPTHQPSGPYPSISSQMPSNPGAAENFYTGQQQASYQASPQHQHYQQPPHATPQPQYPPYGSAPEPQPGQYPPQHVQGSDSWQNRAPSAPQDQYQQQQPQNPQPPQAPVPSDPNASYYFTPQQPQQAPLGPSAPGAAPDAAQSPYPSLQSPSQYPGGSVPVPSQPTPGQTPSQPAQAPQQPVQSPQLQHSQPQQPQMGQQAPPPQQQAYWQPSMPQQHQQPSAAPQNWAYGGYTQDSFPSVPQQEPAKQPAKEEALIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RW89</accession>
    <name>I1RW89_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG08550.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T10241</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320203.1">
        <property type="nucleotide sequence ID" value="XM_011321901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RW89"/>
    <dbReference type="FunCoup" id="I1RW89">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF76924">
        <property type="protein sequence ID" value="CEF76924"/>
        <property type="gene ID" value="FGRRES_08550"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08550"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10241"/>
    <dbReference type="eggNOG" id="ENOG502S4CU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097653_0_2_1"/>
    <dbReference type="InParanoid" id="I1RW89"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="86"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF76924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="207" mass="23561" checksum="2A50F56FD50764A0" modified="2012-06-13" version="1">MAGDEEHDGASVQEILIEACRRNNVELLDECLEEKTDAEISKLLNETKTVMGNHLYHEAASRGNYEIIDHLLDQPEFECDPVNTREGDTPLHTVIRWINSEPPAQRPFGNAIVEMMLEAGSNTRVKNKARLTPYQLVDPTNTELRELIQKHEYANQNAGDFINVNNSTNQGALLDVPDESDDDAEFSGSDDEERAEWERRRKAKQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1RYB5</accession>
    <name>I1RYB5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG09358.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T27273</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328387.1">
        <property type="nucleotide sequence ID" value="XM_011330085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RYB5"/>
    <dbReference type="STRING" id="229533.I1RYB5"/>
    <dbReference type="EnsemblFungi" id="CEF83447">
        <property type="protein sequence ID" value="CEF83447"/>
        <property type="gene ID" value="FGRRES_09358"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09358"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27273"/>
    <dbReference type="eggNOG" id="ENOG502RWC4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015101_3_1_1"/>
    <dbReference type="InParanoid" id="I1RYB5"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124608" evidence="2">
        <location>
            <begin position="18"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF83447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="301" mass="32851" checksum="C52AAC48073B0024" modified="2012-06-13" version="1">MLSSWVIGLCASSLVRALPVSDYYTVKAPRLIVFGDSFSDNGNGSWIVSNGTWPADPAYYRHSFSNGLKWNDLVAKDLGLELINLATGGATTNNNFVAGGTGAQSTIPVPSASDQVFSFLSWNKPRPDDVFVHWIGANDILFNTSITGGQVTSLINENVDRLYHAGAKRIILANYLKITTFPATYSSPDYDIPSVEVYSSALTQGLKNIAAAYSAYAQTAVIDVGNLFKDITLDPESYGFDEKYLNPPTACLTGVYTSEGVPRHLCNDPQKHVFFDSYHPGKEVHALIAKLFEQEIRQFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RYV7</accession>
    <name>I1RYV7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 4, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="10" type="primary">FG09568.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T26775</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CEF84017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="EnsemblFungi" id="CEF84017">
        <property type="protein sequence ID" value="CEF84017"/>
        <property type="gene ID" value="FGRRES_09568"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26775"/>
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    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
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        <source>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1RYZ0</accession>
    <accession>A0A098DUU2</accession>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328102.1">
        <property type="nucleotide sequence ID" value="XM_011329800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RYZ0"/>
    <dbReference type="STRING" id="229533.I1RYZ0"/>
    <dbReference type="EnsemblFungi" id="CEF85119">
        <property type="protein sequence ID" value="CEF85119"/>
        <property type="gene ID" value="FGRRES_09606"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09606"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26687"/>
    <dbReference type="eggNOG" id="ENOG502QQV3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019832_1_0_1"/>
    <dbReference type="InParanoid" id="I1RYZ0"/>
    <dbReference type="OrthoDB" id="2422440at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47482:SF5">
        <property type="entry name" value="FAR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47482">
        <property type="entry name" value="OS11G0632001 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="652"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="250"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF85119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="725" mass="82898" checksum="B3597878891A4B12" modified="2012-06-13" version="1">MSSLRPGSNSHTGLNFPQASLRRNPYPPPHPGQQNKQSPAPHSAPPYQTQAYQPQQPPTGYHQHLFSNPTHVNGSLSNGSSRSSTSHMSNAVPSPLDVSNPRGLPQSRSQMMFPTLGQVVPNQLHHPQQQQQMHPQHLSHATHPLNQPRQTLHQHHAQQSPQQRPQSQQAQPTPKLGQVQVKPQAPSPPLPQQSSQQQAQSHQQLQQQLQQQQQQHHLQQQQQLQQQQQQQQLQQQQQQQQQQQQQQQQQQQLQQQQQQHHQQQVHPQQQHQQQQAQHQQQQAQLHPQQQQQLRTPQQEQQQLQHAQQHEQPRAQPHQQPAPRQQKQQKQRDQQREQQRDQQAQQQQLQQQQQLQQQQQAQQQAQQQAQQQAQQQAQQQAQQQAQQQAQQQPKQQPAPPEPVQQQAQPQPQQQKPDATGEESMDIDSHANGEETGGLDMKLLADPNYIPTQPLGEMMSPPPEGGSYPTLEAVQKAVLRYCTSVGYAIVIGRSKKTVPGLKKVLFVCDRAGKPPSRVSPECRKRKTSSRKCDCPFGFFAIEQRTQWTIRYRPDPSHLQHNHGPSESPSHHPAARKLDSKMVAAVKQLKENGAGVSETLQILQTENPDCHLLPRDIYNARAAINRNPQKVATGLAENRPAIYSKPHQSPEDRIRAELRREIAKAREDMQKMEEEKDKEISELKEKIVEKDGIIKKFEEFIDICNERVMFQRQRLAGSNSNGANQPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZ83</accession>
    <name>I1RZ83_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Folic acid synthesis protein FOL1</fullName>
            <ecNumber evidence="10">2.5.1.15</ecNumber>
            <ecNumber evidence="12">2.7.6.3</ecNumber>
            <ecNumber evidence="11">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Folic acid synthesis protein fol1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">FG09710.1</name>
        <name evidence="26" type="ORF">FGRAMPH1_01T26457</name>
    </gene>
    <organism evidence="26 28">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="27">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="27 28" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="28">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="27">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="26 28" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="26">PH-1</strain>
        </source>
    </reference>
    <reference evidence="27" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes three sequential steps of tetrahydrofolate biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the central section; belongs to the HPPK family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="10"/>
    <dbReference type="EC" id="2.7.6.3" evidence="12"/>
    <dbReference type="EC" id="4.1.2.25" evidence="11"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327992.1">
        <property type="nucleotide sequence ID" value="XM_011329690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZ83"/>
    <dbReference type="FunCoup" id="I1RZ83">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RZ83"/>
    <dbReference type="EnsemblFungi" id="CEF83879">
        <property type="protein sequence ID" value="CEF83879"/>
        <property type="gene ID" value="FGRRES_09710"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09710"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26457"/>
    <dbReference type="eggNOG" id="KOG2544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008023_2_1_1"/>
    <dbReference type="InParanoid" id="I1RZ83"/>
    <dbReference type="OrthoDB" id="615426at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Dihydropteroate synthase"/>
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        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
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        <property type="entry name" value="folK"/>
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        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
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        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HPPK"/>
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        <property type="entry name" value="Pterin_bind"/>
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        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
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        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="16" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="25">
        <location>
            <begin position="266"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
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            <dbReference type="ARBA" id="ARBA00001353"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
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            <dbReference type="ARBA" id="ARBA00005013"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00012458"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00013043"/>
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            <dbReference type="ARBA" id="ARBA00013253"/>
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            <dbReference type="ARBA" id="ARBA00022679"/>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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            <dbReference type="ARBA" id="ARBA00022909"/>
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            <dbReference type="ARBA" id="ARBA00058009"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00061548"/>
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    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00067568"/>
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    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00068111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="CEF83879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="535" mass="58008" checksum="1ED00632559388FB" modified="2012-06-13" version="1">MRQSFLSSRALAQGLRSAPCNASPSLSRAFTTSPRYSLTSTRPRKPSLIAAARPHSLARNTVPGLRNNACGCACANGGGCGSNGPRKRTAYIALGSNMGDRVAEIERACNEMDRRGIKVKRTSSLWETEPMYVTDQDRFVNGACEVETELEPIALLDQLQAIENDMGRKKVIDKGPRNIDLDILLYGDETVDHERLKVPHIGILEREFVLRPLAELIPAKSLDPRKPWKLIQDNLNELPLGEPLSSMTPLSAKAGSLTPLASKRKTHVMGILNLTPDSFSDGGRHDRDNLAQTIVDMVKNGTSIIDVGGQSTAPGRPEVSAEEEAARVVPAIELIRSIPEAREVAISIDTYRASVAEQAIASGADIINDVSAGMLDPDMLSTVARLQKTICLMHMRGTPQTMTKLTSYPEGLIPTLASELLSRVAAAEEAGIRRWRMILDPGIGFAKTGEQNIEILRRLEELRYWPGLEGLPWLVGSSRKAFVGKITGVTEPAQRTWGTAATVAAAVQGGADVVRVHDTAEMGMVAKMADAIWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZJ5</accession>
    <name>I1RZJ5_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle subunit SRP14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Signal recognition particle 14 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG09842.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T26151</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SRP14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327840.1">
        <property type="nucleotide sequence ID" value="XM_011329538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZJ5"/>
    <dbReference type="STRING" id="229533.I1RZJ5"/>
    <dbReference type="EnsemblFungi" id="CEF83345">
        <property type="protein sequence ID" value="CEF83345"/>
        <property type="gene ID" value="FGRRES_09842"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09842"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26151"/>
    <dbReference type="eggNOG" id="ENOG502S9PU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094309_1_0_1"/>
    <dbReference type="InParanoid" id="I1RZJ5"/>
    <dbReference type="OrthoDB" id="19209at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003210">
        <property type="entry name" value="Signal_recog_particle_SRP14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12013">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02290">
        <property type="entry name" value="SRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF83345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="128" mass="14287" checksum="0D3C25E4A4093D03" modified="2012-06-13" version="1">MAGSHMSHDEFFAKLGELFDHRKGSDHGSIYLSQKRFTYGQDIPQPSEEEPSPDINPGKPLPLIIKATNGKGKRDRSKKVKLSTVVNPEDLEAFYVRYADVCKTGMTALKPRDRSKKKAKAKKKKAAA</sequence>
</entry>
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    <accession>I1RZV4</accession>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318868.1">
        <property type="nucleotide sequence ID" value="XM_011320566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZV4"/>
    <dbReference type="STRING" id="229533.I1RZV4"/>
    <dbReference type="EnsemblFungi" id="CEF75267">
        <property type="protein sequence ID" value="CEF75267"/>
        <property type="gene ID" value="FGRRES_09959"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09959"/>
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    <dbReference type="eggNOG" id="ENOG502T7MC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1540153_0_0_1"/>
    <dbReference type="InParanoid" id="I1RZV4"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Small_GTPase"/>
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        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF75267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="203" mass="22042" checksum="1978456C74D0E8B8" modified="2012-06-13" version="1">MIAKSTHEQTQKRMEPEYVVKIIILGAPVSGKKSFIRRYCEDVFTDLYEPVEETYEDSRLASIAGIRTLINLERIPSTLLNSAPESCRSAAEADALILLYEGSSPESLEELRRMRLQMLVPYLEEVAPPSAVIAGKADGAEAAGQAWERGLEEGSNLAVSLDAKFGVASALWGDGVKDVVEELAARVLENKGVDKEVLMGAGS</sequence>
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    <accession>I1RZZ0</accession>
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        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
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    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CEF75324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_011320619.1"/>
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    <dbReference type="AlphaFoldDB" id="I1RZZ0"/>
    <dbReference type="EnsemblFungi" id="CEF75324">
        <property type="protein sequence ID" value="CEF75324"/>
        <property type="gene ID" value="FGRRES_10000"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10000"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07037"/>
    <dbReference type="eggNOG" id="KOG1890">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_006249_1_0_1"/>
    <dbReference type="InParanoid" id="I1RZZ0"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034753">
        <property type="entry name" value="hSac2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF7">
        <property type="entry name" value="SACI DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G15890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="253"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="HSac2" evidence="3">
        <location>
            <begin position="692"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="205"/>
            <end position="233"/>
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    </feature>
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        <location>
            <begin position="810"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
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            <begin position="131"/>
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    </feature>
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        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF75324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="945" mass="105251" checksum="9631891F231DE7F1" modified="2012-06-13" version="1">MPAIARKLLICAAIDGLVIQPLSSKGQRPFQPVRVKYGDASVSRIQREYGLDDSKPDPSFEAFGVIGLITVSKSSYLVTITRRQQVAQICGHPIYVVTEVAITPCTSKIGAEEAIKRTSDHISRQARDSGDESDSSEEEEVEFPSRASDEVEDAIIDDDDARPGSARSRVAEDVIRRRGSYGRFAQRWFSRSGWTLDQKRNMGLSNAPKVSETASTAAESSSDEAQESLDKVAPSEPELLPKLLRTAQVLFGSSRSFYFSYDFDLTRSLDERSVPQNAETPLHNQVDEVFFWNRNLLQPFTSSGQDCLALPLMQGFVGQKTFIVDNQPPQSDDKGKESVELSDLSPTKEHSEFPGFGSSRASIDLRSSERKYLITVISRRSTKRAGLRYLRRGIDQDGFVANMVETEQLLSSPTWDPSSNVYSFLQVRGSIPLFFKQSPYAFKPTPIQQHSEEANQAACLRHFESLSRNYGQLQIVNLVEKHGVESIIGGAYEKAVEEVNKEASQDNKIPFEWFDFHAACKGMKFENVSMLLDQLRDKIESFGSTVQKDGNQVSRQKGVFRTNCMDCLDRTNVCQSSFAKHMLEVQLKEEGFDMSAQTDQVTAWFNTLWADNGDAVSKQYASTAAMKGDYTRTRKRDYRGALNDLGLGLARYYSGMVNDYFSQAAIDFLLGNVTAKIFEEFESDMMTKDPAVSVTKMRELAVELCQKRVIADEKEEFHGGWVLLSPTTPDAIRSWPLEEVVLLLTDAALYSCRFDWKSDKVSSFERVELDSVTGIKYGTYITSTISLSHVDEIKNAGFVVTYSPGKSDIRRTNTRTLSSHGTMTGKDSPAEQKDASLPASLANLLTSKTSSAPPLSVRRLVFKATNADSSVAVLGDDGPKQTETQQVSTICGDIERLALERHPRQPDEEHESLVETGPIISLEEAKKNTGLLEQLGHSLKKMVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>I1S060</accession>
    <accession>A0A098DAG2</accession>
    <name>I1S060_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">U3 small nucleolar RNA-associated protein 25</fullName>
            <shortName evidence="10">U3 snoRNA-associated protein 25</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">FG10076.1</name>
        <name evidence="14" type="ORF">FGRAMPH1_01T07225</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
            <location evidence="2 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the UTP25 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319008.1">
        <property type="nucleotide sequence ID" value="XM_011320706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S060"/>
    <dbReference type="FunCoup" id="I1S060">
        <property type="interactions" value="1262"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1S060"/>
    <dbReference type="EnsemblFungi" id="CEF75417">
        <property type="protein sequence ID" value="CEF75417"/>
        <property type="gene ID" value="FGRRES_10076"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10076"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07225"/>
    <dbReference type="eggNOG" id="KOG2340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018705_0_1_1"/>
    <dbReference type="InParanoid" id="I1S060"/>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002356">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 10" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP25 NTP hydrolase-like" evidence="13">
        <location>
            <begin position="257"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="UTP25 C-terminal" evidence="12">
        <location>
            <begin position="525"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="119"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CEF75417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="719" mass="81979" checksum="4C472560F9227401" modified="2012-06-13" version="1">MPPRGRGGNFRGRGGRGRGRGGRGGKATSRFGPNRRFDGARLAENDGLESSGSESESAPEDTVMEDLESEDEDDDEETASAKPYMALLQSFNNESNAPNSKRRKLDHKESAQSQPGEDSSSDEEGEEGQDDPEKDIDRAEDEAEDQVEEQVDDDDDSEDEENPTDPFDVHFAHPDEDIVAKRVKSAQEGNWATKRALIQTLRATVTYPASDAGSEVPKPIAGLDGLQLKQKLKEISSRKIGEFSAVQRNLSPLIFNYNDVLFCDRTVRNSDSLRELTCLHALNHVFKTRDRVIKNNYKLAKEGQDNDLELRDQGFTRPKVLFLLPTRNSCLRMVNMIRDLCEPDQQENRKRFDDGYVDKEARFGADRPADFKDLFEGSDDDMFRLGMKFTRKTVKYFSQFYNSDILFASPLGLRMAIGSEEDKKLDFDFLSSIEMVVVDQADALLMQNWEHVEFIFEHLNLQPKDAHGCDFSRVRNWYLEDWAKYFRQTIILSAFNTPELSELLRLHCHNWAGKVRLQPEYPGTLSQLGVKAKQTFSRFQSKSVDKDPDARFEYFTSAIIPSLAKRAKDATGTLIFVPSYLDFVRVRNYFATSSSVENVTFGAISEYTDVPEASRARSHFLSGRHRVLLYTERAHHFRRYQFRGVQRVIFYGLPDNPIFYTEIAGGYLSKSEQDLRLEPGQGTAKVVFSKYDVMKLERIVGSKRVGKMIQDRGDTFEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1S0I1</accession>
    <name>I1S0I1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG10209.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T07547</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319156.1">
        <property type="nucleotide sequence ID" value="XM_011320854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S0I1"/>
    <dbReference type="FunCoup" id="I1S0I1">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF75577">
        <property type="protein sequence ID" value="CEF75577"/>
        <property type="gene ID" value="FGRRES_10209"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10209"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07547"/>
    <dbReference type="eggNOG" id="KOG4366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040660_2_0_1"/>
    <dbReference type="InParanoid" id="I1S0I1"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF75577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="345" mass="38795" checksum="0BAFD0F7CA63A657" modified="2012-06-13" version="1">MAGAAKKMFGLSQVVPVVMPLIAGSAGYAAYRVNWGPLIREFLTGPGRTSRILLLFFIVFNWKSMPFAWTYRVLYTIFLHGYWRKSPSLGPDALFKPMISTTHAPILEIDYNLHKSNSTYFADLDVSRSHLVTYLCRASYMTLANNAKTKLVLDPKTDQPIKGNVSIILGSVACSFKREIPAFKNFEMWSRILCWDRKWLYIVTHYIPKGAAKPTSWLDPTFKETSARGPQDAAGGWHRRIYATAISKYVFKLGRFTVNPAIMLGGASGLLPERPGGWTTGPEQLGDMSVDLSDVDLEVSGEWDWRRVEAQRRKGVEYAKHFQELDTLHELFDGGNEGALGKFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I1S0N3</accession>
    <name>I1S0N3_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-1-tetrahydrofolate synthase, cytoplasmic</fullName>
            <ecNumber evidence="8">1.5.1.5</ecNumber>
            <ecNumber evidence="7">3.5.4.9</ecNumber>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">FG10267.1</name>
        <name evidence="23" type="ORF">FGRAMPH1_01T07687</name>
    </gene>
    <organism evidence="23 25">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="24">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="24 25" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="25">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="24">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="23 25" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="23">PH-1</strain>
        </source>
    </reference>
    <reference evidence="24" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="7"/>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319220.1">
        <property type="nucleotide sequence ID" value="XM_011320918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S0N3"/>
    <dbReference type="FunCoup" id="I1S0N3">
        <property type="interactions" value="1225"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1S0N3"/>
    <dbReference type="EnsemblFungi" id="CEF75647">
        <property type="protein sequence ID" value="CEF75647"/>
        <property type="gene ID" value="FGRRES_10267"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10267"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07687"/>
    <dbReference type="eggNOG" id="KOG4230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003601_2_0_1"/>
    <dbReference type="InParanoid" id="I1S0N3"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009257">
        <property type="term" value="P:10-formyltetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001123">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.770:FF:000001">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="17" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="21">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="22">
        <location>
            <begin position="143"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CEF75647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="939" mass="100557" checksum="A98CEC5A54360E21" modified="2012-06-13" version="1">MVATKLDGNAIAKSIREKLCAEVNEKQKINPRFKPCLKIIQVGDRSDSSTYVRMKLKAAAEAGIDSQLLHYPESISEAELLDHIRQHNNDPAVHGILVQLPLPKHISEYTVTSFVADEKDVDGFGTKNIGELAKRGGKPLFIPCTPKGCMILLKESGIDLKGKNAVVLGRSDIVGSPVSYLLRNADATVTVVHSKTQNIEQHVRNADVLVAAIGQPLFVPGSWIKPGAVVIDVGTNFLPDATKKSGHRLVGDVDYASAVEVASAITPVPGGVGPMTVAMLMQNVVDATTWYFESQKLRKTIPLPLKLEDPVPSDIAVSRAQTPKDITRIAAEIGIAPHELEPYGAYKAKVDLGLMQRLEHRRNGRYVVVTGITPTPLGEGKSTTTMGLAQALGAHVGRMTFANVRQPSQGPTFGIKGGAAGGGYSQVIPMDEFNMHLTGDIHAIGAANNLLAAAIETRIFHENTQKDGPLYKRLVPVKNGARKFAPVMFRRLKKLGIDKTNPDELTEDEIHRFARLDIDPETITWRRVLDVNDRHLRGITVGAAPTEKGQTRETGFDITVASECMAILALSNNLAEMRERLGSMVVATSRGGDPVTADDLGAGGALTALMKDAIKPNLMQTLEGTPVFVHAGPFANISIGQSSILADKLALKLAGTEADEDHQKKAGFVVTEAGFDFTMGGERFFNIKCRTSGLVPDVVVIVATVRALKVHGGAPPIAPGAALSPVYKEENVDILRAGCVNLKKQIANAKSFGIPVVVAINKFATDTDAEIAVIREEAVSAGAENAILSNHWAEGGKGAVDLAHGVIAAAEKPKDLKFTYNLEGTVQERLEAIGKQMYGAEKVELSELAQKKVDTYTRQGFGHLPICVAKTQYSLSHDPDLKGAPTGFTVPIRDVRLAAGAGYFYALAADIQTIPGLPTAPGYLNVDVNVETGEIEGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1S2A1</accession>
    <name>I1S2A1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG10887.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T20717</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325499.1">
        <property type="nucleotide sequence ID" value="XM_011327197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S2A1"/>
    <dbReference type="FunCoup" id="I1S2A1">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1S2A1"/>
    <dbReference type="EnsemblFungi" id="CEF87372">
        <property type="protein sequence ID" value="CEF87372"/>
        <property type="gene ID" value="FGRRES_10887"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10887"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20717"/>
    <dbReference type="eggNOG" id="KOG1120">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069054_0_0_1"/>
    <dbReference type="InParanoid" id="I1S2A1"/>
    <dbReference type="OrthoDB" id="333486at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
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    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044572">
        <property type="term" value="P:[4Fe-4S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000001">
        <property type="entry name" value="Iron-binding protein IscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="5">
        <location>
            <begin position="136"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00071673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF87372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="239" mass="26522" checksum="C49F742F28E83BD3" modified="2012-06-13" version="1">MFTSRSVARLVLRRACSPLPVSSPLRQFSTSRPLAVSYHSYTLPTHTSTPPRNDDVPETSIAQPDPLPKVHETRPPPQQPQHPQPPKQQEAATTTTTTQNDVPATSASAPKLNEMEAQKPKAARPRSKLRPRKAAMKLTPSAVEQLRELLDQPEPKLIKVGVRNRGCSGLAYHLEYVDKPGAFDETVEQDGVKVLIDSKALFSIIGSEMDYVEDKLNQRFVFKNPNIKEECGCGESFMV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-06-17" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>I1S2J4</accession>
    <accession>A0A098E2D6</accession>
    <name>NRPS9_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nonribosomal peptide synthetase 9</fullName>
            <shortName evidence="10">NRPS 9</shortName>
            <ecNumber evidence="12">6.3.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">C64 cluster protein NRPS5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Fg3_54 cluster protein NRPS9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Fusaoctaxin A biosynthesis cluster protein NRPS9</fullName>
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    </protein>
    <gene>
        <name evidence="10" type="primary">NRPS9</name>
        <name evidence="8" type="synonym">NPS9</name>
        <name type="ORF">FG10990</name>
        <name type="ORF">FGRAMPH1_01T20959</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2011" name="Mol. Plant Microbe Interact." volume="24" first="995" last="1000">
            <title>The transcriptome of Fusarium graminearum during the infection of wheat.</title>
            <authorList>
                <person name="Lysoee E."/>
                <person name="Seong K.Y."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="21585270"/>
            <dbReference type="DOI" id="10.1094/mpmi-02-11-0038"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2012" name="Plant Cell" volume="24" first="5159" last="5176">
            <title>In planta stage-specific fungal gene profiling elucidates the molecular strategies of Fusarium graminearum growing inside wheat coleoptiles.</title>
            <authorList>
                <person name="Zhang X.W."/>
                <person name="Jia L.J."/>
                <person name="Zhang Y."/>
                <person name="Jiang G."/>
                <person name="Li X."/>
                <person name="Zhang D."/>
                <person name="Tang W.H."/>
            </authorList>
            <dbReference type="PubMed" id="23266949"/>
            <dbReference type="DOI" id="10.1105/tpc.112.105957"/>
        </citation>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="e110311" last="e110311">
            <title>The Fusarium graminearum genome reveals more secondary metabolite gene clusters and hints of horizontal gene transfer.</title>
            <authorList>
                <person name="Sieber C.M."/>
                <person name="Lee W."/>
                <person name="Wong P."/>
                <person name="Muensterkoetter M."/>
                <person name="Mewes H.W."/>
                <person name="Schmeitzl C."/>
                <person name="Varga E."/>
                <person name="Berthiller F."/>
                <person name="Adam G."/>
                <person name="Gueldener U."/>
            </authorList>
            <dbReference type="PubMed" id="25333987"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0110311"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="922" last="922">
            <title>A linear nonribosomal octapeptide from Fusarium graminearum facilitates cell-to-cell invasion of wheat.</title>
            <authorList>
                <person name="Jia L.J."/>
                <person name="Tang H.Y."/>
                <person name="Wang W.Q."/>
                <person name="Yuan T.L."/>
                <person name="Wei W.Q."/>
                <person name="Pang B."/>
                <person name="Gong X.M."/>
                <person name="Wang S.F."/>
                <person name="Li Y.J."/>
                <person name="Zhang D."/>
                <person name="Liu W."/>
                <person name="Tang W.H."/>
            </authorList>
            <dbReference type="PubMed" id="30804501"/>
            <dbReference type="DOI" id="10.1038/s41467-019-08726-9"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2019" name="Toxins" volume="11" first="277" last="277">
            <title>Fusaoctaxin A, an example of a two-step mechanism for non-ribosomal peptide assembly and maturation in fungi.</title>
            <authorList>
                <person name="Westphal K.R."/>
                <person name="Nielsen K.A.H."/>
                <person name="Wollenberg R.D."/>
                <person name="Moellehoej M.B."/>
                <person name="Bachleitner S."/>
                <person name="Studt L."/>
                <person name="Lysoee E."/>
                <person name="Giese H."/>
                <person name="Wimmer R."/>
                <person name="Soerensen J.L."/>
                <person name="Sondergaard T.E."/>
            </authorList>
            <dbReference type="PubMed" id="31100892"/>
            <dbReference type="DOI" id="10.3390/toxins11050277"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="6 7 12">Nonribosomal peptide synthetase; part of the Fg3_54/C64 gene cluster that mediates the biosynthesis of the octapeptide fusaoctaxin A, a virulence factor that is required for cell-to-cell invasiveness of plant host (PubMed:30804501). The 2 nonribosomal peptide synthetases NRPS9 and NRPS5 form an assembly line which likely utilizes GABA as a starter unit (loaded on the unique module M1 of NRPS9) and sequentially incorporates seven extender units composed of the residues L-Ala, L-allo-Ile, L-Ser, L-Val, L-Ser, L-Leu and L-Leu, respectively (PubMed:30804501, PubMed:31100892). During the process, each of the residues that are tethered on modules M3-M7 of NRPS5 containing an E domain can undergo an epimerization reaction to produce a D-configuration before the transpeptidation reaction occurs (PubMed:30804501, PubMed:31100892). The elongation of the peptidyl chain might be terminated by module M8-mediated L-Leu incorporation, followed by R domain-catalyzed 4 electron reduction to release the resulting octapeptide from the assembly line as an alcohol (PubMed:30804501, PubMed:31100892). Fusaoctaxin A is cleaved by the cluster specific ABC transporter FGM5 to the pentapeptide fusapentaxin A and the tripeptide fusatrixin A (PubMed:31100892). The other enzymes from the cluster, FGM1, FGM2, FGM3 and FGM9 seem not to be involved in the biosynthesis of fusaoctaxin A and their functions have still to be determined.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="induction">
        <text evidence="3 4 5 7">Expression is positively regulated by the cluster-specific transcription factor FGM4 and is induced during infection of coleoptiles of wheat seedlings (PubMed:23266949, PubMed:25333987). Expression is also up-regulated during infection of barley (PubMed:21585270). The fusaoctaxin A gene cluster is silenced by H3K27 trimethylation by the histone methyltransferase KMT6 (PubMed:31100892).</text>
    </comment>
    <comment type="domain">
        <text evidence="12">NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, epimerase (E) domains (responsible for L- to D-amino acid conversion) are present within the NRP synthetase. NRPS9 has a reduced A-T architecture.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4 6">Leads to reduced virulence.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.-" evidence="12"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325380.1">
        <property type="nucleotide sequence ID" value="XM_011327078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S2J4"/>
    <dbReference type="SMR" id="I1S2J4"/>
    <dbReference type="STRING" id="229533.I1S2J4"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T20959">
        <property type="protein sequence ID" value="FGRAMPH1_01T20959-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G20959"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10990"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20959"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_2_12_1"/>
    <dbReference type="InParanoid" id="I1S2J4"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="PHI-base" id="PHI:9043"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF16">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE ATNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000449945" description="Nonribosomal peptide synthetase 9">
        <location>
            <begin position="1"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="2 12">
        <location>
            <begin position="722"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylation (A) domain" evidence="1 12">
        <location>
            <begin position="202"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="21585270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="23266949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="25333987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="30804501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="31100892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="21585270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="9">
        <source>
            <dbReference type="PubMed" id="25333987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="10">
        <source>
            <dbReference type="PubMed" id="30804501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="11"/>
    <evidence type="ECO:0000305" key="12">
        <source>
            <dbReference type="PubMed" id="30804501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF88261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="819" mass="89202" checksum="1CE04EA284492FAE" modified="2012-06-13" version="1">MAPLNTYTSTEVLLLDNACNDVHELGRALWSITVDRYHHRDEWTLTCLAEAHGRWDMTYRLVSIQNATTIGQLLAAERLVESPKDASDEDNIFAFATTGSRLPVRTLLGRSSFILQLSEFDGRPTAQVLFSGANNKGQARILLNVFHSLWETHGSSPLNAERPVCEVGGLSYEDVRILELVNSGRLAQQQECIHDVVLQHALQAPTQHAVRAWDGNLTYHQLNDHADRIATMLVSAGIGPGDFIPSIMEKSYWTIVVILATLKAGAVFVPIDPKCPASRINGIFLQVWPKVYFTNLGPQMRRKLNPSVACVDNFAEIVQQVQPGPLPPSRPDAIATCFFTSGSTGKPKGAIHDHSAIATGIVDLLGPFHMDSRTSSMHFVSPSFDVSVTEIAATLYAGGCICVPSEQGKLNDLNGQMRALGVTHAFLTPSVACQVKPSEVPTLQYIMLGGEPLGRATLEALCEDVHLINVYGSTESGLWDTASERLTLQSKPSNIGRSTGPRMWIVHPGNPGNLLPFGTVGEVMVESHCLARGYIGNQPAKTGFVPAPEWRHQLFPGMEQGRFYLTGDLGSYNPDGSIMLHGRKDTQAKIRGQRIELGEIEHQFKAALPTSRVVAEVVTIGSRTMLAAFVELSTAEDKTDIEPSVCVDSLSIRTAQAARLGATPALSAALPVYMVPEMYIPVNSIPLTMSGKTDRRRLRELASTITTVQLEMINGVDDEKEQPRNERERLIQATWAAVLQRKASTIGIHDHFFKIGGDSLSAMKVVAAARSRQLVINVGDILGHPTIASLAEFLSSSSTISYATKGMANRDIQVTVTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1S2W7</accession>
    <accession>A0A098E0G2</accession>
    <name>I1S2W7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG11123.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T21273</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325229.1">
        <property type="nucleotide sequence ID" value="XM_011326927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S2W7"/>
    <dbReference type="STRING" id="229533.I1S2W7"/>
    <dbReference type="EnsemblFungi" id="CEF87590">
        <property type="protein sequence ID" value="CEF87590"/>
        <property type="gene ID" value="FGRRES_11123"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11123"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21273"/>
    <dbReference type="eggNOG" id="KOG3867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_10_0_1"/>
    <dbReference type="InParanoid" id="I1S2W7"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16142">
        <property type="entry name" value="ARS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF42">
        <property type="entry name" value="ARYLSULFATASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14707">
        <property type="entry name" value="Sulfatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF87590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="446" mass="50030" checksum="0B1F0500148E6DA9" modified="2012-06-13" version="1">MSKDPSKPNIVLILADNLGWGELGCYGGGLLRGAATPRIDNLATEGLLLHNFNVESDCVPTRSALMTGRHPIRTGCRQSVPAGFPQGLTRWEQTLPECLKPKGYATAHHGKWHLGDIPGRYPSDRGFDEWFGIPRTTDESQFTSALGYTPEVAELPYIMKGCAGQDSENVCVYDLEKRRLIDEMLVDQSKDWLSRQVKAEKPFFLYHPLVHLHFPTLPHRNFEGKTGQGEFADSMAEMDYRVGQLIDHLDELGVRENTVLIFASDNGPEFRPPYKGTAGPWSGTYHTAMEGSLRVPFIIRWPGHVPSGVTSNEIVHVTDIFTTILEIAGAEAPSDRPIDGVSQVSFFENPNSVKSQRQGFLFYIKDELRAVKWKDWKLHLVWEPKVNQSSGKLESPYLFNVVRDPKEETDVLAYNTWVMQPVMKLKAAFDKSLKNDPAPPDPLKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>I1S3S6</accession>
    <accession>A0A098DX25</accession>
    <name>I1S3S6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">FG11472.1</name>
        <name evidence="15" type="ORF">FGRAMPH1_01T22149</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325744.1">
        <property type="nucleotide sequence ID" value="XM_011327442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S3S6"/>
    <dbReference type="SMR" id="I1S3S6"/>
    <dbReference type="STRING" id="229533.I1S3S6"/>
    <dbReference type="EnsemblFungi" id="CEF86405">
        <property type="protein sequence ID" value="CEF86405"/>
        <property type="gene ID" value="FGRRES_11472"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11472"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22149"/>
    <dbReference type="eggNOG" id="KOG4266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003559_3_1_1"/>
    <dbReference type="InParanoid" id="I1S3S6"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="PHI-base" id="PHI:5900"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02124">
        <property type="entry name" value="PA_PoS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07489">
        <property type="entry name" value="Peptidases_S8_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034187">
        <property type="entry name" value="Peptidases_S8_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 9 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124799" evidence="11">
        <location>
            <begin position="18"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="12">
        <location>
            <begin position="155"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="13">
        <location>
            <begin position="382"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="14">
        <location>
            <begin position="615"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CEF86405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="875" mass="92250" checksum="3B5F0D923DE1BED6" modified="2012-06-13" version="1">MVRFGLSALLFAGLSLAQDELSQPPQPEQGTVAHLPGAYIFEFEESQDTSVFYDKTESQSTTRVKFDYDLFKGVSVQFDDVASAEELAAKMAALPVVKNVWPVKVYGIPAPRVEWVAEPGMKAPLSKRAVNDTADTFSPHVMTQVDKLRKKGITGHGIKVAVIDTGIDYKHPALGGCFGPDCLVSFGTDLVGDDYDGFNAVHPDDDPMDCAGHGTHVAGIVAAQTNPFGFTGTAPGVTLGAYRVFGCSGEAGNDVLIAAYNQAYQDGADIITASIGGPSGWSEEPWAVAVSRIVEKGVPCPVSAGNSGDVGMFYASTAANGNKVMAIASYDNSDYISLLKQHHYTVDGSDTKIAFGMTAGTPAAWDDVKLPIWAPSLDTTVANGGCDPYPADTPDLSKFIVLVRRGTCTFAQKAQNAANAGAKYFIVYNNAGGANEIDVSAVKSILAAGMVTSKVGAKWIGLLKEGSKVTLEMSAGSDGEVIMEESKNDKTGGAVSTYSSWGPTWEMDVKPQFGSPGGNILSTYPLAKGGYAVLSGTSMACPLVAATIALIAEVRGTLDPETIENLLASTSNPQLFNDGTGFSDYLAPVPQQGGGMIQAYDAAYSTVLMDVSSLSFNDTDNFIKVRNFTIHNTGKKEIDLSVSHIPTKSVYTLDKDSIYASTFPNDVADAHAELKFSEAKLSVGAGEKVTIEVVPSAPEGLDAKRLALWSGYIAINGTGVSLSLPYQGMTGSLHDSVVLGSDDTWIARSNDKDKLTPVPANTTFILPVKGQNATDAQPAPALAWKLALGSAKLEAELIPVGGNSTKSLGAPAGFPVQWNPMGDGNIVWNGKLADGGYAPAGKYKVKYQALRIFGDEKVKSDWDHSESPVFSVKYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1S3X8</accession>
    <name>I1S3X8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG11528.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T16017</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323098.1">
        <property type="nucleotide sequence ID" value="XM_011324796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S3X8"/>
    <dbReference type="STRING" id="229533.I1S3X8"/>
    <dbReference type="EnsemblFungi" id="CEF79808">
        <property type="protein sequence ID" value="CEF79808"/>
        <property type="gene ID" value="FGRRES_11528"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11528"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16017"/>
    <dbReference type="eggNOG" id="ENOG502RM4B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035914_0_1_1"/>
    <dbReference type="InParanoid" id="I1S3X8"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124806" evidence="3">
        <location>
            <begin position="22"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF79808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="390" mass="42818" checksum="6481C24573210FAF" modified="2012-06-13" version="1">MKVSFGILATLLGASSYVASAAPTDQSSASDLILSLNEKATSALENAETEPRKRSAGPKKCTIFNAAVRRDWKTLSKKDKKAYIDAVLCLRKKPSKADPAFAPGARSRYDDFVAVHINQTLSIHGTGNFFTWHRYFTWAYEKALQDECGYKGTQPYWNWFETGDFATNPVFDGSETSMSGDGKYFEHDGAWSGKQNIFIPSGKGGGCIKNGPFAGAVANLGPPSPGMTGMEATTTPLNYNPRCLRRDLSSYSIDQWLNLPNLYNITLGKASNTIQAMQDEFQGRFSDKFLGMHAAGHFVMGGDSADLFSSPNDPVFFLHHSMVDRIYWVWQALHPRRAKDIAGTITILNTPPSRDAVKSDVLNMGVNAPLITIEDGLDTLAGSPFCYIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1S5M0</accession>
    <name>I1S5M0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG02457.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T05895</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="FGRRES_12141"/>
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    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="PROSITE" id="PS50850"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1S6S5</accession>
    <accession>A0A098DFB4</accession>
    <name>I1S6S5_GIBZE</name>
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            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
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    <gene>
        <name evidence="12" type="primary">FG02951.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T11691</name>
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    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="11 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322847.1">
        <property type="nucleotide sequence ID" value="XM_011324545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S6S5"/>
    <dbReference type="ESTHER" id="gibze-q4iik7">
        <property type="family name" value="Tannase"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF77649">
        <property type="protein sequence ID" value="CEF77649"/>
        <property type="gene ID" value="FGRRES_12548"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12548"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11691"/>
    <dbReference type="eggNOG" id="ENOG502QPXZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014819_1_0_1"/>
    <dbReference type="InParanoid" id="I1S6S5"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009997680" description="Carboxylic ester hydrolase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF77649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="528" mass="58036" checksum="67A4CD32E63DC8B3" modified="2012-06-13" version="1">MRANSLLLSGLAVCAAAAPEKAKDNFVSKCASFKNSLKLPNTTVWFTEHVPAGKNLTFPENDVTCSPKSQVVDVELCRVAMLVTTGPRSNLSLEAWLPSNWTGRFLSTGNGGMAGCIQYGDVAYGAGFGFATVGANNGHNGTSALPMKNNSGSVEDYVYRSVHTGTVLGKDIAKQFYGKKYTKSYYLGCSTGGRQGWKEAQSFPDDFDGIVAGAPAIRFNGLQSRSGSFWGFTGAPGAPTHLSPEEWNMVHDDVLAQCDVPLDGVDDGIIEDPNLCQYRPEAIICTKGQTKNCLTAPKAETVRQVFSPLYGNNGSFIYPRAVPGANASRSFVIGETPFPYSTEWFQYIILNNTNWKPEDIGPDAYQATEEVNPFNVQTWEGDLSKFRDRGSKIIHWHGLQDGLISSDNSMDYYNHVSRTMGMSNTELDKFYRYFRVSGCGHCSGGDGANRIGNNLSNLGGKDPKNNVLLAIIKWVEEGVAPDTITGMRFANGANNGKFEYERRHCRYPYRNVWDRKGDWKNPNSWKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1S6S7</accession>
    <accession>A0A098DFE7</accession>
    <name>I1S6S7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T11679</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322853.1">
        <property type="nucleotide sequence ID" value="XM_011324551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S6S7"/>
    <dbReference type="EnsemblFungi" id="CEF77643">
        <property type="protein sequence ID" value="CEF77643"/>
        <property type="gene ID" value="FGRRES_12550"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12550"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11679"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013002_0_0_1"/>
    <dbReference type="InParanoid" id="I1S6S7"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="333"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="491"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF77643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="558" mass="61184" checksum="5E8B7EDEAE29435D" modified="2012-06-13" version="1">MMQSRMSIADRIKDMFRRAESDYPLHASICNNDVSTLQEVLGSREASFLLLDGDGCWGTPLHVAVYLDNIEAANLILQVGVGVDVTADSSAHEHQLSPLALAARLGNKRLLWRLWQHLHSQEKESLANVDSCLFEASINSQTTILRALLSWKEWTAEAKSEALFWAARSWKAYSAQLLTTQLSFPQDVLDKALHHAVGFRPLIGDDFKLDYNGDDYLQQQLLIAHLIDAGANPNAIINRQPPIITAARSREVSIALPWFTNLFKPSGPVVRLNETAIRILLSYNASVSLGDDESGANPLHAAAFGSSLNMLQLYLSSCPSEQTSQASRSKNNFGETLLHYAAAGAKRDIIEFLLSQGLDVNGINTNGWTPLHCALTPARQGSQLNGFSKSTSEALEIAKILLLHGADPRAVTVEGWTPLHCLSLFAGKKKENTELGQFVDNMIHRGVDIHARATFLFWNELGNVEPKYHYWGHEVQDSIQEPETSGAIVRFGYTPLHFSAAHGSISMAKALLDLGADPLSKDARGNTAIKIAANSLLLDDRPSTRNAIVKLLTEAAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1S7H3</accession>
    <name>I1S7H3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T18615</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324306.1">
        <property type="nucleotide sequence ID" value="XM_011326004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S7H3"/>
    <dbReference type="STRING" id="229533.I1S7H3"/>
    <dbReference type="EnsemblFungi" id="CEF88651">
        <property type="protein sequence ID" value="CEF88651"/>
        <property type="gene ID" value="FGRRES_12796"/>
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    <dbReference type="eggNOG" id="ENOG502ST0G">
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    <dbReference type="OrthoDB" id="5334244at2759"/>
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        <property type="component" value="Chromosome 3"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF88651.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88651"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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    </evidence>
    <sequence length="140" mass="15410" checksum="8B8023C213FC9325" modified="2012-06-13" version="1">MRFLTPLRPTARIAPRLTTLRPFHQARTLRKENAKDSNGSFVDGLAEGDAKGRTGGGKPLDASSKNAPPQPKVSNQSIPGNQTDTLTEEQKREVEEHNRDFDAKHDRGNTAPGDKVDKKFWGGAQHGEKDKGNVKPDDEK</sequence>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327058.1">
        <property type="nucleotide sequence ID" value="XM_011328756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S8D9"/>
    <dbReference type="EnsemblFungi" id="CEF85260">
        <property type="protein sequence ID" value="CEF85260"/>
        <property type="gene ID" value="FGRRES_13117"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13117"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24491"/>
    <dbReference type="HOGENOM" id="CLU_2197214_0_0_1"/>
    <dbReference type="InParanoid" id="I1S8D9"/>
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        <property type="component" value="Chromosome 4"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF85260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="108" mass="12549" checksum="A538735E1EB6544E" modified="2012-06-13" version="1">MIWSVSGGQVASKVSEQLRNKFIKLIFSKRTLWPYQRPPDTECLMDQREPRTIDANVPWSSTWFSSSELNTTNLRCICHDDQSDGSRTVDFAIKEFMLLQPDFSSRML</sequence>
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        <submittedName>
            <fullName evidence="7">Chromosome 4, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327255.1">
        <property type="nucleotide sequence ID" value="XM_011328953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S8H5"/>
    <dbReference type="STRING" id="229533.I1S8H5"/>
    <dbReference type="EnsemblFungi" id="CEF85552">
        <property type="protein sequence ID" value="CEF85552"/>
        <property type="gene ID" value="FGRRES_13153"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13153"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24917"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="3142841at2759"/>
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        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF5">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01222)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="567"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="596"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="682"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="721"/>
            <end position="738"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="758"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="36"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF85552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="985" mass="107792" checksum="48B4D250B857E985" modified="2012-06-13" version="1">MDMTNPMQDDILYDSILELGQGDCIDTPFSTVTSAFYHHAKKYPDATALRDITESPKELTYRELANRAQNLASHLIAQGVCPDSRIPLVAKRGIDMVIGILAILSCGAQYVPLDGGVVPDETIRRVLEESKGGVVLCLTSTKHRVESHFGHTVVAIDQVATPSLEENSHIDLASPETGCYVIYTSGTTGKPKGVDVTHKNVANLVCLSPGDLGVKVGTCVGSVLNISFDMAAWEIFVCICNGGTLVLRGSSWESTLQQIDVLICTPTILSKYHPAQFPRIKTVATAGEPTTRRLADLWAEHGTYWNCCGPTETTVVNTMHKHTVGKELSIGRPTPNNRVYVLDGEGKPTPMGTVGVMWAGGLGVSRGYIGLEDKTAERYKPDPFSRDGSLIYNTGDLGRWLPDGSIEILGRVDDQVKVKGFRVELDGVTASLVSAPGVSQAAALLIDGEIHGFITPRNCDVTTTIKHMHQHQPYYAVPTHLHALDELPSTPNGKVDKNRLKVLALTEQSTTTQACENEKIQESRVELKFQPSMSTLATLTDKLDLESGIPDKAMARPLRGLRRRVFIVYRTLFSLIGLLNLAALICVIALHLDSEWLGIITAINLAVAVLVRQDTVINILYTIFCSMPKSFPLWARVRCAKIYHLGGLHSGAGVCATAWLVISTVRGTICNAGFCKGHATVSLATLVVSWILCGLLCSMVATAWPSFRKQYHNFFERFHRFAGWTSLGLFWARTILAINDSRPQGQDLRLAAVKSPDFWLLIVATLSIASSWFFLRKVPVEAEVLSDHAVRLHFDYTVPVNGSFTRLSRRPLIEWHSFATIPNPEANGHAKGYSLVVSNAGDWTRSCIKNPPSKIWVRGVPTCGVMRIATLFNRVVIIATGSGIGPLLGHIVKQSCPTQLIWSTTRPENTFGKELVGQVRDAIPDAIIWDTKAQGRPDLVRMGYNVAKNFDAEAVIIIANEKITKKVVYGLETRGMPAFGAIWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I1S8V5</accession>
    <accession>A0A098DEB1</accession>
    <name>I1S8V5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG08839.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T10963</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319873.1">
        <property type="nucleotide sequence ID" value="XM_011321571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S8V5"/>
    <dbReference type="EnsemblFungi" id="CEF77284">
        <property type="protein sequence ID" value="CEF77284"/>
        <property type="gene ID" value="FGRRES_13283"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13283"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10963"/>
    <dbReference type="HOGENOM" id="CLU_1261610_0_0_1"/>
    <dbReference type="InParanoid" id="I1S8V5"/>
    <dbReference type="OrthoDB" id="5025019at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="219" mass="25302" checksum="84AEDE4C15018CED" modified="2012-06-13" version="1">MRRDFEENPPEGARDFRMDLPSSNPEKHFEYVYDPGLGDIVPNLEPPPPPSEPRMIGVYFGFDEDHPEGEVHLQVLQDLFPSNIEDFVRSDEVRFPELPDKVKPILMRFLYTGELKRPKVNACSTLDELYEAFEIMFHLNAAGCYSAIITLTAESHASLWLINLYMSEEETKDIIEEIQEDWPNCSPNWYKAFLADCEYTRVNAMATESKKPLTYDPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I1S9E6</accession>
    <accession>A0A098DVP7</accession>
    <name>I1S9E6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T28283</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328864.1">
        <property type="nucleotide sequence ID" value="XM_011330562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S9E6"/>
    <dbReference type="EnsemblFungi" id="CEF85432">
        <property type="protein sequence ID" value="CEF85432"/>
        <property type="gene ID" value="FGRRES_13477"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13477"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G28283"/>
    <dbReference type="eggNOG" id="ENOG502RP4P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037030_3_1_1"/>
    <dbReference type="InParanoid" id="I1S9E6"/>
    <dbReference type="OrthoDB" id="5131365at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF85432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="134" mass="15164" checksum="E13D04DEA33CA9A5" modified="2012-06-13" version="1">MIYEKDRLDGERRAKRKAASLESDRPIKIVDVLPTPPSSNFGTASPSVVDLTYLVIPKPIDRAVDDYTEWLCDQVEDENWKAGFRSAGSITRADCLDLRHVYQDRDIGYYVNQGVKAGIARSFVQDIKIWADSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I1S9K1</accession>
    <accession>A0A098DVU6</accession>
    <name>I1S9K1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T27599</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328537.1">
        <property type="nucleotide sequence ID" value="XM_011330235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S9K1"/>
    <dbReference type="EnsemblFungi" id="CEF85479">
        <property type="protein sequence ID" value="CEF85479"/>
        <property type="gene ID" value="FGRRES_13532"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13532"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27599"/>
    <dbReference type="HOGENOM" id="CLU_2291965_0_0_1"/>
    <dbReference type="InParanoid" id="I1S9K1"/>
    <dbReference type="OrthoDB" id="10301112at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF85479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="101" mass="11154" checksum="564544DCC1603A21" modified="2012-06-13" version="1">MDAAMKPCFEFSSSLCVCAGLVHIPGIPRITTESKRPWQCFTSLFRVENDKKIVSRTQRSRLSQLPGETGRTTHHPPIELHDLTNSLLAGQAALAEATYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I1S9Z5</accession>
    <accession>A0A098D9Z0</accession>
    <name>I1S9Z5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T06971</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318889.1">
        <property type="nucleotide sequence ID" value="XM_011320587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S9Z5"/>
    <dbReference type="EnsemblFungi" id="CEF75290">
        <property type="protein sequence ID" value="CEF75290"/>
        <property type="gene ID" value="FGRRES_13676"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13676"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06971"/>
    <dbReference type="HOGENOM" id="CLU_2264013_0_0_1"/>
    <dbReference type="InParanoid" id="I1S9Z5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF75290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="103" mass="11710" checksum="43EBDED683D3B17E" modified="2012-06-13" version="1">MPVTCYYTQPIFGKPDYSTKRFNQDGSKCKSNTQQVSPGVPWTRFGLYTHGYDDANTLPALRLDKFQPTDLPHNQPHISTRWSGGRSGQRVASRLVLNQTHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1SAA6</accession>
    <accession>A0A098DAN0</accession>
    <name>I1SAA6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T08441</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF76023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319572.1">
        <property type="nucleotide sequence ID" value="XM_011321270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1SAA6"/>
    <dbReference type="EnsemblFungi" id="CEF76023">
        <property type="protein sequence ID" value="CEF76023"/>
        <property type="gene ID" value="FGRRES_13787"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13787"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08441"/>
    <dbReference type="eggNOG" id="ENOG502QW0W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035063_0_2_1"/>
    <dbReference type="InParanoid" id="I1SAA6"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF56">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="13"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="339" mass="37757" checksum="1476BAEB22581D7D" modified="2012-06-13" version="1">MKIKASLPDKLKSIRNAGFDGIELSMPDIISYGELLNGSSPAEDDYDTLADVAKKIKSLTDELGLKIMMLQPFANFEGWNKVTHGKQRQKAFDKAKGWIKVMEAAGITLLQVIRAHTTPSLPVLTFSQVGSSDSEGISSSFDDLASDLAELADLLAEKNFSIAYENWCWATHAPTWKTVWQIVQKADRPNIGLCLDTFQTAGYEWGDPTTNDGLTSASSSDERQNRWEMSLQELAATVPAEKIYLLQISDAYKMDPPIKNVKDEQGSRPRARWSHDYRPLPCDGGYLPVQDMMASVLKTGFRSWLSVEVFDGLEGENTDMNDYTKMAFESVNKLIDFSG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2023-02-22" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>V6QVS3</accession>
    <name>AQP1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aquaporin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FgAQP1</name>
        <name type="ORF">FG00811</name>
        <name type="ORF">FGRAMPH1_01T02029</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2018" name="Curr. Genet." volume="64" first="1057" last="1069">
            <title>Aquaporin1 regulates development, secondary metabolism and stress responses in Fusarium graminearum.</title>
            <authorList>
                <person name="Ding M."/>
                <person name="Li J."/>
                <person name="Fan X."/>
                <person name="He F."/>
                <person name="Yu X."/>
                <person name="Chen L."/>
                <person name="Zou S."/>
                <person name="Liang Y."/>
                <person name="Yu J."/>
            </authorList>
            <dbReference type="PubMed" id="29502265"/>
            <dbReference type="DOI" id="10.1007/s00294-018-0818-8"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Probable water channel involved in responses to changes in environmental conditions and conidiation (PubMed:29502265). Involved in responses to hyperosmotic conditions, oxidative stress and cell wall destabilization (PubMed:29502265). Also required for proper transcriptional activation of genes involved in aurofusarin biosynthesis (PubMed:29502265). Not involved in pathogenicity, but negatively regulates deoxynivalenol (DON) production (PubMed:29502265).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="4">Localizes to the nuclear membrane in conidia but not in hyphae.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Leads to whitish colonies with longer aerial hyphae and reduced conidiation and perithecium formation, with morphologically abnormal conidia that undergo abnormal germination (PubMed:29502265). Increases the conidium autophagy (PubMed:29502265). Results in a significant higher production of deoxynivalenol (DON) but does not affect pathogenicity (PubMed:29502265). Exhibits increased resistance to osmotic and oxidative stress as well as cell-wall perturbing agents (PubMed:29502265).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316524.1">
        <property type="nucleotide sequence ID" value="XM_011318222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6QVS3"/>
    <dbReference type="SMR" id="V6QVS3"/>
    <dbReference type="FunCoup" id="V6QVS3">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="229533.V6QVS3"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T02029">
        <property type="protein sequence ID" value="FGRAMPH1_01T02029-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G02029"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00811"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02029"/>
    <dbReference type="eggNOG" id="KOG0223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_1_7_1"/>
    <dbReference type="InParanoid" id="V6QVS3"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000014">
        <property type="entry name" value="Aquaporin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000457431" description="Aquaporin-1">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="6">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="6">
        <location>
            <begin position="130"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="6">
        <location>
            <begin position="187"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="6">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="6">
        <location>
            <begin position="258"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="268"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="NPA 1" evidence="7">
        <location>
            <begin position="107"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="NPA 2" evidence="7">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="29502265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="29502265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="29502265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72815"/>
        </source>
    </evidence>
    <sequence length="318" mass="34405" checksum="231F33C9FB231FC3" modified="2014-02-19" version="1">MVQFGSRANTNMTGLPTEQAVEDRRVGNPKRDRMRNALVIVLGEFCGTFMFLLLSFIGAQTALVTNSPSDAGSPLLPFSLMYIAASFGTALAVNVWIFYRVSGGMFNPAVTLGLVLVGAVTPIHALLIIPTQLVAAITAAGITDALLPGKLLVTNALGNGTSVAQGVFIEMFLTSQLVLTVYFLAVEKHRSTHLAPIGIGISVFIAHICATNWTGTSINPARSFGPSVVAGFHGYDWIYYIGPFMGSLLAFGCYKIFKVLEYQTANPGQDDDNLDRSGHHHFFGHRKEPMPHTHTDNIEPKDHGVPQRNDSVIDDQMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>V6RIE5</accession>
    <name>V6RIE5_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Very-long-chain 3-oxoacyl-CoA reductase</fullName>
            <ecNumber evidence="12">1.1.1.330</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">3-ketoacyl-CoA reductase</fullName>
            <shortName evidence="12">3-ketoreductase</shortName>
            <shortName evidence="12">KAR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Microsomal beta-keto-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG05670.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T18475</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="EC" id="1.1.1.330"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.330" evidence="12"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324241.1">
        <property type="nucleotide sequence ID" value="XM_011325939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6RIE5"/>
    <dbReference type="FunCoup" id="V6RIE5">
        <property type="interactions" value="742"/>
    </dbReference>
    <dbReference type="STRING" id="229533.V6RIE5"/>
    <dbReference type="EnsemblFungi" id="CEF88309">
        <property type="protein sequence ID" value="CEF88309"/>
        <property type="gene ID" value="FGRRES_05670"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05670"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18475"/>
    <dbReference type="eggNOG" id="KOG1014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_38_0_1"/>
    <dbReference type="InParanoid" id="V6RIE5"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045703">
        <property type="term" value="F:ketoreductase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141040">
        <property type="term" value="F:very-long-chain 3-oxoacyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
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    </dbReference>
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        <property type="entry name" value="Very-long-chain 3-oxoacyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03107">
        <property type="entry name" value="3_ketoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027533">
        <property type="entry name" value="3_ketoreductase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF88309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="334" mass="36647" checksum="FCDB3C48B4663B30" modified="2014-02-19" version="1">MTAIADFFENVPQPLQWGLAGVGALFLGSKILSYLQLVLSAFVLGGTNLRKYGKPGTWAVITGASDGLGKEYALQLAAKGFNLVLVSRTLSKLETLSTEIQQKYSGKGLQIKVLDMDFSKNNDADYERLSELIYGLDVGILINNVGQSHSIPVPFLETTKEELENIITINCTGTLRVTQTVAPIMKARKNGLILTMGSFGGWTPTALLATYSGSKAFLQQWSNALAAELADDKVDVYLVLSHLVTTAMSKIRRPSLLVPNARNFVKATLGKVGLGGYQTAPYTYTPWWSHSFMLWFIENIPGANGPITMSVNKKMHEDIRRRALRKAAREAKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>V6RQW4</accession>
    <name>V6RQW4_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Imidazole glycerol phosphate synthase hisHF</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">Glutaminase</fullName>
                <ecNumber evidence="12">3.5.1.2</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">Cyclase</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="18" type="primary">FG09984.1</name>
        <name evidence="17" type="ORF">FGRAMPH1_01T06987</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">In the C-terminal section; belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="12"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_011318896.1">
        <property type="nucleotide sequence ID" value="XM_011320594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6RQW4"/>
    <dbReference type="FunCoup" id="V6RQW4">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="STRING" id="229533.V6RQW4"/>
    <dbReference type="EnsemblFungi" id="CEF75298">
        <property type="protein sequence ID" value="CEF75298"/>
        <property type="gene ID" value="FGRRES_09984"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09984"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06987"/>
    <dbReference type="eggNOG" id="KOG0623">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037550_0_0_1"/>
    <dbReference type="InParanoid" id="V6RQW4"/>
    <dbReference type="OrthoDB" id="10254903at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000094">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000039">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050064">
        <property type="entry name" value="IGPS_HisA/HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014640">
        <property type="entry name" value="IGPS_HisHF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF2">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036936">
        <property type="entry name" value="IGPS_HisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51274">
        <property type="entry name" value="GATASE_COBBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 12 15" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="16">
        <location>
            <begin position="6"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="359"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="397"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="469"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="495"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="518"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CEF75298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="549" mass="59922" checksum="75B208CA8D2BB4A9" modified="2014-02-19" version="1">MPTVHLLDYVAGNIRSLVNAIEKCGYEVEWVRSPEEVPNAEKLILPGVGHFGHCLSQLSQAGYLEPIKKHIADGKPFFGVCVGLQALFQGSVEDPDIPGLGVVPATLDRFDDSSKSVPHIGWNNAFTAGKAMYDLQPDSKYYYVHSYKCPYKPGELESQGWAVATGTYGAETFVGAIAKGNIYATQFHPEKSGAAGLRTLRAFLTGEGLKTLGNVVDEAVANAPIKFEDSLTRRVIACLDVRTNDQGDLVVTKGDQYDVREKGDDRNVRNLGKPVEMAKRYYESGADEVTFLNITSFRDCPVADLPMLEIVRQTSRTVFVPLTIGGGIRDTVDTDGTKVSALEIATMYFKSGADKVSIGSDAVLAAEEYYSLGRKLFGNTAIEQISRAYGNQAVVVSVDPKRVYVPKPDATRHNIVKTQFPGPKGEEYCWYACTIKGGRETRDMDVVELTQAVEAMGTGEILLNCIDKDGTNSGFDFELINQVKGAVKIPVIASSGAGNPSHFEDVFQKTPTDAALGAGMFHRGEYTVKQVKDYLQEKGLKVRQFEEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D0I9</accession>
    <accession>A0A0E0RL00</accession>
    <name>A0A098D0I9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG00084.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T00251</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF71925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D0I9"/>
    <dbReference type="EnsemblFungi" id="CEF71925">
        <property type="protein sequence ID" value="CEF71925"/>
        <property type="gene ID" value="FGRRES_00084_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00251"/>
    <dbReference type="eggNOG" id="ENOG502S3TD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098D0I9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08495">
        <property type="entry name" value="PBP2_NikA_DppA_OppA_like_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.76.10">
        <property type="entry name" value="Dipeptide-binding Protein, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.105.10">
        <property type="entry name" value="Dipeptide-binding Protein, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290:SF9">
        <property type="entry name" value="OLIGOPEPTIDE-BINDING PROTEIN APPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PERIPLASMIC BINDING COMPONENT OF ABC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Solute-binding protein family 5" evidence="4">
        <location>
            <begin position="46"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF71925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF71925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="472" mass="53546" checksum="5A380B0B1E31645F" modified="2015-01-07" version="1">MSDILRIVLENVDFRLPTQVTDDNSVLALKSLVFEPLIRWQTGGEILPGLFHKWDVSEDQRTWFFYIRDEAVFHDGTPCDAPLIVEYINGFLDSHDYFGMAWSYSRYFANTTFTTENAKVVKIQNQNPFPDLLNVLNDFWPSRIDDNEKPILGTGPYRVVKFTRQDNIGSATLELLDSAQHPDWPRNIVATAARDGEERLKLLQSGQVDAALNLERIDNLKLINFQSPLQWGRVPSTLSVIYYLNCPEGVFSSPQVRLAANLAINNQALVDEVYFGLATPAATVVSPHHLGFKEANLSPIPYDPERAKELIKHLDLRKPLRLRTPEWMPEHAIKITEFVKRSLESIGFKVDVEVETNRPEYARSIGLRKNIGDLACFDSTPNTTFRVLDDKVSSESHGTWWLGYHDDEFQRLFAKARGAAGGDDRKKAYAEALKRVHENPPWLYIAHPDVIWATKDGVELSIGPSGVLELGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D3K8</accession>
    <accession>A0A0E0RQP4</accession>
    <name>A0A098D3K8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG01434.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T03527</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D3K8"/>
    <dbReference type="STRING" id="229533.A0A098D3K8"/>
    <dbReference type="EnsemblFungi" id="CEF73569">
        <property type="protein sequence ID" value="CEF73569"/>
        <property type="gene ID" value="FGRRES_01434"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03527"/>
    <dbReference type="eggNOG" id="ENOG502S7CI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098D3K8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008402">
        <property type="entry name" value="APC_su15/mnd2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05841">
        <property type="entry name" value="Apc15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF73569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="376" mass="42780" checksum="EEC2D907B0607B76" modified="2015-01-07" version="1">MFTTLPDFTPRDSHSLWYRSSRSPYIPPGPLDDFNEGAHNQQHGANQARQRTRIIERSALARLAADEQYMQRRRLNVQNYGSGWLKPPGVPKTLHQMREEKREQEEHQEAMRREQLAQELAEAEAAGAPGEEGTMDDVQLDGAQDLDDEIPDADDGYGFDDDEEEEEEDDDEEEEEEEEEEEEEEEEEEEGEGEGEEDGEETDDEALRAERENNLMAAHMRMGDDAFREALVRGEPDSNDMYGEAEEYEEEETNGQLLDEEDFVQEDDLGMDMDADLDEDIPEAESQGYEHTDSEAEISSSEQRSSSDEEEEEEEDDLDTSFQPRSTTLPPPLSPTFHGGRSLMSHPRASMDLSNLLSQDGSSFMHSSPAGRRARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D621</accession>
    <accession>A0A0E0RQ61</accession>
    <name>A0A098D621_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T03167</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D621"/>
    <dbReference type="EnsemblFungi" id="CEF73386">
        <property type="protein sequence ID" value="CEF73386"/>
        <property type="gene ID" value="FGRRES_15840"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03167"/>
    <dbReference type="InParanoid" id="A0A098D621"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF73386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="103" mass="11692" checksum="D7516DA963E6EA72" modified="2015-01-07" version="1">MTPISSFNAFNTNPQTWSSASNGHGHDSKNLGSTNSNRSDKQRGVALRLEVAVQVWRRTLTRDFGARFQFGRTIRDLDSTSPHQTTRTHGTVFLLRQFLSSYY</sequence>
</entry>
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    <accession>A0A098DC40</accession>
    <accession>A0A0E0RXN7</accession>
    <name>A0A098DC40_GIBZE</name>
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        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG10563.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T08419</name>
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    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the secreted LysM effector family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF76012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DC40"/>
    <dbReference type="STRING" id="229533.A0A098DC40"/>
    <dbReference type="EnsemblFungi" id="CEF76012">
        <property type="protein sequence ID" value="CEF76012"/>
        <property type="gene ID" value="FGRRES_10563_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08419"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DC40"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF2">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="44"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="163"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="251"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF76012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="380" mass="40289" checksum="51FFDFCE39EDF15F" modified="2015-01-07" version="1">MSLSFFSSIFQSNEMHLTTFLAVGLLPALPYARSIPSRRGVDCSFHTSPDSGATCATFADAWGMSEDDLKALNTGIKCPNIDTGATYCVIGSVNDDPDEPSPTAVGPKSTAAASTKVTSVIKTTPTAVSPTVPQKPSTTKQPSGNGIKTPDAIQEGMVTNCNKFHEVKDTTTCQGILNYNKISLADFVKWNPAVGKDCSKLWKGTSACVGVIGSTPSSTGATKPSPTKATPGNGIKTPEAIQEGMVSNCNKFHEVKDTTTCQGIVEYNKITLADFIKWNPAVGKDCSKLWKGTSACVGVIGSKPQPTATAPSNGIKTPSPIQAGMVKNCVTFHYISSTTTCQALLKYRKITMEQLFKWNPAVKKDCSGLWKDTHACVAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DCP6</accession>
    <accession>A0A0E0RZP4</accession>
    <name>A0A098DCP6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="3" type="primary">FG08388.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T09833</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DCP6"/>
    <dbReference type="STRING" id="229533.A0A098DCP6"/>
    <dbReference type="EnsemblFungi" id="CEF76719">
        <property type="protein sequence ID" value="CEF76719"/>
        <property type="gene ID" value="FGRRES_08388_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09833"/>
    <dbReference type="eggNOG" id="ENOG502SKB6">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A098DCP6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="RBD_domain_sf"/>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
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    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <property type="gene ID" value="FGRRES_13372"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="CEF76754.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    <sequence length="84" mass="9209" checksum="797E7B30C7945E48" modified="2015-01-07" version="1">MHVILSTQATRPYHIRQVSISSRAVHGTPLIQKAKVFRYTPHVGVRLGQIVNHAELHSLANAELGACVSHDQDTTTSSASRLKL</sequence>
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<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A098DDS5"/>
    <dbReference type="EnsemblFungi" id="CEF76610">
        <property type="protein sequence ID" value="CEF76610"/>
        <property type="gene ID" value="FGRRES_20119"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09615"/>
    <dbReference type="InParanoid" id="A0A098DDS5"/>
    <dbReference type="Proteomes" id="UP000070720">
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            <end position="78"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76610.1"/>
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    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF76610"/>
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    </evidence>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="9 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
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    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A098DKA9"/>
    <dbReference type="FunCoup" id="A0A098DKA9">
        <property type="interactions" value="39"/>
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    <dbReference type="STRING" id="229533.A0A098DKA9"/>
    <dbReference type="EnsemblFungi" id="CEF78366">
        <property type="protein sequence ID" value="CEF78366"/>
        <property type="gene ID" value="FGRRES_03544_M"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13125"/>
    <dbReference type="eggNOG" id="ENOG502QRIP">
        <property type="taxonomic scope" value="Eukaryota"/>
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        </source>
    </evidence>
    <sequence length="278" mass="30483" checksum="D5E4155C312FF044" modified="2015-01-07" version="1">MRGLIILASLSHLATTLTIPTYPKKRALSAGIAIYSCTTPGTVALTFDDGPFIYTESVLDQLASAGFKATFFLNGYNLGNIEDYQSTVDRMINEGHQVASHTYGHPDLAALNDYDVEQQMVLLSNQFTHMIGKDPVYMRPPYFSFNDRTLQVLGQLGYKVVIADIDTDDWRYSSFGGAEPSLDLYNAGLNHGGSIVLMHDVHQNTVQDILPRIIQATRQSGRRAVTVGECLGDPETNWYRVSGGSGGGSHRTEWNSTETQDNVVVVHTPAPEKLGVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DKM0</accession>
    <accession>A0A0E0S7P4</accession>
    <name>A0A098DKM0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T15435</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DKM0"/>
    <dbReference type="EnsemblFungi" id="CEF79519">
        <property type="protein sequence ID" value="CEF79519"/>
        <property type="gene ID" value="FGRRES_15249"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15435"/>
    <dbReference type="InParanoid" id="A0A098DKM0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF79519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="60" mass="6428" checksum="F9B81E91111BB0D8" modified="2015-01-07" version="1">MRRVLKGLGCCWLRSEAKGQAVHAAKLRGMAYVVGVGGVLEVRLRPLLQAVARLDIGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DNR3</accession>
    <accession>A0A0E0SAN8</accession>
    <name>A0A098DNR3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG07126.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T24025</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DNR3"/>
    <dbReference type="STRING" id="229533.A0A098DNR3"/>
    <dbReference type="EnsemblFungi" id="CEF83501">
        <property type="protein sequence ID" value="CEF83501"/>
        <property type="gene ID" value="FGRRES_07126_M"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502R95R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DNR3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010018717" evidence="2">
        <location>
            <begin position="20"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF83501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="390" mass="41883" checksum="1B3D5A566439FFF7" modified="2015-01-07" version="1">MRFHLGIATFILFASIVATSNVAYAPTQSHSARIPFHSLSFETRSTSKMAPASNAKANYKTYEAQARMVRAIVAAHPDVKWNYKEIAACYGSDMTDHALNHRFRKVRAATNIISIARAQGYDMKDMSTDENLLPSTQQGIDKNNIAKYFGQSTTDGIQFQFRTIKKDAEALRQTANNGGDVAGCLNLGTGAGPNTPSKPTPARSQVSRSGKGSKRKSSLPVHPIKRSDSDDEDEDDMNFDELDYTPSKRTKTTGRGVTPRTAGRKAAATIAESSTQYPDSESPNEDAPTPTPAAAGQFTYAGHGGHASHAGHPAASAATFAPVPAVSIFGNVERKPSIPIPTPTATATPDSLSIFMSGRSEFPGAFLDDSNVLEPPPDDEHYFDWGNGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DRN9</accession>
    <accession>A0A0E0SDL2</accession>
    <name>A0A098DRN9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG07620.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T25233</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DRN9"/>
    <dbReference type="EnsemblFungi" id="CEF84525">
        <property type="protein sequence ID" value="CEF84525"/>
        <property type="gene ID" value="FGRRES_16861"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25233"/>
    <dbReference type="eggNOG" id="ENOG502T9IA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DRN9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF84525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="306" mass="34556" checksum="BD62114EBCEAB52A" modified="2015-01-07" version="1">MTRDILIVGATGQQGKATINALFNTLKHSPQHNTRILALTRSISSPKSLALHSQYPDIILVGGNTQTPKPIFKQFPSIASIFIVTIPPDDEAQAIPLIEEATSKTSQVDHIVFSSVDRGGDEVSWSQPTEIPHFAAKHRIEHRLRELCEQTGKRWTILRPTGFMDSYNPDFFGKMMASLWAEGMPKDRKMQLISTHDIGLFAAKALLDPESWAGKSLALAGDDLSFSDVERIFRDVVGEQLPQTYKAVSWPILWLVKDASQSFEWFRTAGWKADIDNLRRQEPGLQNFETWLRESSRWKVQNISQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098E1X6</accession>
    <accession>A0A0E0SKZ5</accession>
    <name>A0A098E1X6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG05588.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T18275</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098E1X6"/>
    <dbReference type="EnsemblFungi" id="CEF87108">
        <property type="protein sequence ID" value="CEF87108"/>
        <property type="gene ID" value="FGRRES_16506_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18275"/>
    <dbReference type="eggNOG" id="ENOG502RF8N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098E1X6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098E4E3"/>
    <dbReference type="EnsemblFungi" id="CEF88477">
        <property type="protein sequence ID" value="CEF88477"/>
        <property type="gene ID" value="FGRRES_15262"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16575"/>
    <dbReference type="InParanoid" id="A0A098E4E3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF88477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="84" mass="9656" checksum="5A7E354D9F7F952C" modified="2015-01-07" version="1">MNERDGETSQMITEKFKTKDELVNVNPMNTKRKMRLLYKRVLYNLCLAAPRTVILLLLHSTLTPLLDSSTDLNVFSSLPKEETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RMM5</accession>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="19">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="19">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="14"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RMM5"/>
    <dbReference type="FunCoup" id="A0A0E0RMM5">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A0E0RMM5"/>
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        <property type="protein sequence ID" value="CEF72500"/>
        <property type="gene ID" value="FGRRES_17603_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01399"/>
    <dbReference type="eggNOG" id="KOG0354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0RMM5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18033">
        <property type="entry name" value="DEXDc_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12091">
        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18801">
        <property type="entry name" value="SF2_C_FANCM_Hef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001992">
        <property type="entry name" value="ATP-dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000861">
        <property type="entry name" value="Fanconi anemia, complementation group M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.20">
        <property type="entry name" value="hef helicase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044749">
        <property type="entry name" value="FANCM_DEXDc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="162"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="506"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="62"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="686"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="851"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1045"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="700"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="857"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="881"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="919"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="941"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="968"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1000"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CEF72500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1092" mass="121460" checksum="3EDF9FE1839AF81B" modified="2016-04-13" version="1">MDSDEFDDDIADEDFLTALDQVSSSMNGQSTAASLQTVAGQSGNQRASAAVAALELEDLPSDAFSSPEQNHSRPIASSAISTGAAPRTGLNRASSGNWRQTTLFGGSVANDGPRPSLPTSARVFRADLPREEPTHHEVDHEAMKTWVFPTNLGQTRDYQFSIVKNSLFNNTLVALPTGLGKTFIAASVMLNFYRWTKNAKIVFVAPTKPLVAQQVTACYGIAGIPRSETTLLTGEIPPLLRVDEWAARRVFFMTPQTLLNDISHGYADPKSIVLLVIDEAHRATGEYAYAKVTKLIRRFSKSFRVLALTATPGSKIETVQEVIDNLGISHCEIRTEDSIDIRQYVHSRTIEQVVLDPSDEMVLVSELFTKALKPMTDKLSSQNIWYGRSPMAMTTFGLMKSQKEWFDTGGRRANQGVQHMMRAVFTVLTSIAHSIKLLNFHGIKPFYDNLVDMRSEQEGKGEKGSKYRRQLVQDSNFQEMMDRISKWLRTDGFVGHPKLAALADTVLNHFMDNATNTATRVIVFSEYRDSAEDIVRMLNKHRPLIKARVFVGQADSKRGEGMKQAQQIEAIDRFKEGEFNVLVATSIGEEGLDIGQVDLIVCYDSSASPIRMLQRMGRTGRKQEGKIVLLLMRGKEEEQFAKSKDNYEKMQSLICEGSRFSFRFDLSTRIVPREFRPEVDMRRIDIPVENTQDPSLPEPKKRRAPAGKKKPPKKFHMPDGVETGFQSVASMLKVGGKAKPAKAKRNPELDDLSPVPELTKVLLSDEELKELNRAYRDLPFNHSVVEEADMPDMTAYPDLQRQLRPVAKLKHGTRTKSFVKLWNRMGNEKESLILPCRDKDTSNYLEIPVHAFAGSDPETDSGTDDEAATSRAKPAKVTAAARKKQTRKAPPKAQPRAKRRKLSLDAVPQTFALGSMVDEGLDEDEEDDDEDEEEDDALPKARGRSKPGAKTKGKRKATRKTGGFNSDEVGDDCDRDSDLLDTDGSDDGEDLLDFVVSDNHPVSSMKDPTSLTCPSTFASSPIVKDVDDDATRPFFVPTMFSATQESEDLPDLGRMLDKPGQTAVGLSDDDDVRANRTVRGRRNVVYDSDTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RPD9</accession>
    <name>A0A0E0RPD9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG01048.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T02625</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
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            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <accession>A0A0E0RUX6</accession>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="FGRRES_20084"/>
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            <begin position="1"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF75051.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF75051"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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    </evidence>
    <sequence length="39" mass="4147" checksum="BFC5E24B71529CFA" modified="2016-04-13" version="1">MASKEEEGKGSHHPSSWSGDSSGQAIAPSTIQRHRQSVV</sequence>
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    <accession>A0A0E0SD65</accession>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SD65"/>
    <dbReference type="EnsemblFungi" id="CEF84378">
        <property type="protein sequence ID" value="CEF84378"/>
        <property type="gene ID" value="FGRRES_16927"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25983"/>
    <dbReference type="eggNOG" id="ENOG502RVWT">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A0E0SD65"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
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    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="12"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF84378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="501" mass="56566" checksum="2B7C351DFFDA33A4" modified="2016-04-13" version="1">MPRKGNRKVRSGCLTCKARKVKCDEGKPTCQRCVIGGRPRNHVLGDTARSESRTIEFFCKVVAPTLSGPIDPYFWTHIVLQFSEVEPAVRHSVMTISSLFENRRNPDKSSALAIQRNVVALKHYNAAIRELQSPKSPDLILTLLTCLLFVCIEVLHSNSDVAIRHCYHGINLLGTSDPPEWATRFLMPVFRRLSLLPFYFGDSQPLANCPALTQPSPTITSSFSSHFEAQVSIDAIYNLTIQLFRQTGEFRLGKMRYQPGPPEILAEQNKIHQYLAQWKSAFERFESETSVDISSAIKISRIWPFQLFHVCTVLSTVIFTTEETDYDDFIPNFKGMVKGAAEIAGLRTRPMRSEFHFEMGFAPFLFFVAIKCRDFETRMAGLRLMSVLCAAQESLWNSHTLQVVAQRIIDLEHGVTAGEHSAQYNSLPADDVRVRHFVVGPVKSGPDGLIGREISFYMPTKDGINIKREIFSMKRLNEPLELEGSPGVFTVDLTTETLPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SF70</accession>
    <name>A0A0E0SF70_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG09411.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T27161</name>
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    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SF70"/>
    <dbReference type="EnsemblFungi" id="CEF85083">
        <property type="protein sequence ID" value="CEF85083"/>
        <property type="gene ID" value="FGRRES_17203"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27161"/>
    <dbReference type="InParanoid" id="A0A0E0SF70"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF85083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="600" mass="68089" checksum="D2C41E81EBDA8EF6" modified="2016-04-13" version="1">MAPSCLLLDSAFAVTLKNILQDAIGRLTSPRPSPFAALDRLLISNLIQVSVRESDVLLHCHLLEHFVAIRSKIDAWTDKHAIDEGAAWTCYINAGIRRLTQWFEAALSGLVDLNTHIPPLDVLLVWHAFLQDPVQWKRFTDKTEVEFSGWNSDALSRALQNDESGEFCPSWDCMNKINRVYNHEDVRTFMDSSIDYVFNREDVNDTTTQAVTRLFDSKRLSHKITTLNGEWNFAYNFHSAAQRQLDLAEQVLEFSWHRMYTSPLDNEWGLRAAVKRYRRLMTLAQFRGPIEQLELGMSGCSGVTHLDVDLVWRTHILAPREYRWFCNETFGGLVLNIPSPPGIHGPETVFLDDTSQIYEQVFGEEYAVCLCWPCVDERRADNPGPWNLRWFTGPIPTTPISEEIDRRRNAAVDIPLAFGSKQCRKCGSHPRRQCLKKDVEENLEQEPLLLGHSSTDRVLTPTVPVAARGRIGRLTVPFRDLEVSPLRSETLGETPSRSSVPSGNFETSEATLWDTDRNTIVESLDNDGRRPPTPGLSDGSTCSDDSTDEAAYSNYTLERYANMQRITPLERAFALSTDNRNADATRDSPRGRSRIISRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SI77</accession>
    <name>A0A0E0SI77_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T19679</name>
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    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SI77"/>
    <dbReference type="EnsemblFungi" id="CEF86140">
        <property type="protein sequence ID" value="CEF86140"/>
        <property type="gene ID" value="FGRRES_15334"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19679"/>
    <dbReference type="InParanoid" id="A0A0E0SI77"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF86140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="84" mass="9544" checksum="7D256680E2563EF6" modified="2016-04-13" version="1">MCNTICVMTRCMECRAILERSFGPTVPCDGMKENGVCNVSPDVFVTEILSSSDNCSDCIKRKEELEAEEARRRWGFARTTRCQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SJJ6</accession>
    <name>A0A0E0SJJ6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG05676.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T18491</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SJJ6"/>
    <dbReference type="EnsemblFungi" id="CEF86609">
        <property type="protein sequence ID" value="CEF86609"/>
        <property type="gene ID" value="FGRRES_16523"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18491"/>
    <dbReference type="eggNOG" id="ENOG502SQ0T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0SJJ6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF86609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="211" mass="23781" checksum="26030582C5CA8635" modified="2016-04-13" version="1">MPSPIVAATVQAAGLSTASNIMAQMIEARQANRPMSLDIIQLLRFVVLTLMTAPPNYHWQAFLERKFPAYPVSKRPNLDRLNDLEMQPSQDAPELKEGYEERLTQINKDREPEFSTRNTLTKWFVDCITAGAIMNTVAFLVIMGLLKGQGGSQIWSNIRTETIPIIVAGYKIWPIASIISFTFIPVHRRIVFLSFIGLLWGIYMSLVAARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YHT3</accession>
    <name>A0A1C3YHT3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T02441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YHT3"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02441"/>
    <dbReference type="InParanoid" id="A0A1C3YHT3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB64154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="516" mass="58636" checksum="D1EEEAC879BE1CDD" modified="2016-11-02" version="1">MGSPPLQIFQSMSNSSNDVDLDEFLHVQRLCSTPPNEPAQAQTCLDEIVIPAAASDEIQHKQERQDDTQRGSELNHSRTQPRRRGIRSSASSIPEYSVICFPSNPTKPNGIKKKRKDFDEKRRQEVAQVRKSGACFRCKFRRISCGVGAPCQSCEKAAGILGQQLCIREKLTKMRFSSGDLHYIDYTARLLDQELIAGTTHLGPHRKVSLAMDYPGNPALEVEVQDYYGNTTPPWFCCWVVTDQVGGQVESYRQESARYALPQLLPPSHLVDWVERIISYQETRCIGFQQTVDSFILRYSQSKSPLPMHNFVRKVHKLNCLTKIRLGLILCVEEGGDMTPPSCALHTQFGQISKAASQPIEKEVLLELEKLVFGPTGIGSDNSIALWASLWCLILMYRKLVHTYMAFRQFPCHVPEDYSGFPECKLEVGTHFYHYLVSIYAAMFRVTSPLYADFRVAATRKLLDDDESLIEAFMSLRTESFYFQRESMSMSASPDQLLRRMILDREAGLRPKQISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YI51</accession>
    <name>A0A1C3YI51_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T00709</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YI51"/>
    <dbReference type="STRING" id="229533.A0A1C3YI51"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00709"/>
    <dbReference type="InParanoid" id="A0A1C3YI51"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000929">
        <property type="entry name" value="Ribosomal assembly complex component Ipi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
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    </evidence>
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        <source>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A1C3YIV9"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
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        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844">
        <property type="entry name" value="SER/THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
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        <location>
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            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SCB64478.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
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    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreales</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJE5"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07413"/>
    <dbReference type="eggNOG" id="ENOG502SHVE">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A1C3YJE5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF52">
        <property type="entry name" value="DSBA-LIKE THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="36"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="256" mass="28984" checksum="5EE3250E879615C2" modified="2016-11-02" version="1">MRSLDFPALIYILLPEVFRIIELFHFHKQVNMYESQITLVMDTICPWTYLGKKRLDEALAQFRASPSSSSISFDLQFSSYQPSPSRPETIPDRAAHALHEKHNDNEEAQKLFEEHMISLAKPLNIPIAFTGPTGNSFPAHRIIQQVQESHGPEVTNKLVDALFRLYFAEGRHPGEDDMLIEACVEAGVGEKEAKDLVGDKTKGERKTKEDIRSIGMDIDSVPTVIIEGRRRDLTLTGLKEVSEYVKAMETIKKEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJH5</accession>
    <name>A0A1C3YJH5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T07451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJH5"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07451"/>
    <dbReference type="InParanoid" id="A0A1C3YJH5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008687600" evidence="2">
        <location>
            <begin position="23"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB64565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="187" mass="20911" checksum="51B9E40DBFC1F85A" modified="2016-11-02" version="1">MVVTRASGALALMAIALPIIQATPAIPIGESMEDKSETRIPVVDYLLDPSIPTGDGIDRIIDVMKKEKEEKAIVSRAEPAAARLPWGRLYLNREEQHIPDDDDDSERHEMRSHGKVKRDVVEGVVDDTGSGSAYETVHHKTLDTNETTTANEPRYNRMEQYAQRPTLLHGKTHKVLPQIEKAKSKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJM1</accession>
    <name>A0A1C3YJM1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T17887</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJM1"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17887"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJM1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF164">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SCB64754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="455" mass="51257" checksum="36E69012D2121E43" modified="2016-11-02" version="1">MFILSPSLISGAAALFLVAYIITRLSSATAKIPGPFVSNFTSLVLKWQELNANRTVYIHELHKRYGPVVRVAPNEVSFTSIAAVKEIYGSGGSGYDKTEFYNLFQVYGKRTMFSTLVKGDHAKRRRMIGDRYANSNVMKAAPLAGIKERSSKFLQHCVESPERTADVFDKQDEEMMHQVAADDSLQNRLVQYYSPVLHNLGSKVLASFAKPRSIPLADNFVIENAQQNGAASFTVLNRLKEKDSVLDTMDMAAECLDHMAAGIDTTGDVLCFLMWELSQPRSIKYQRLLREEFLRKTDMPFDELPMLDAVLNEGLRCFPAIPMSLPRYVPQGGRVIDGFTLAEKTVVSCQAMSVHRINDDVFPEPDKFHPERWLAAEGDADRRRHQWAFSSGGRGCVGKHLAMVEMKTLLRDVYSRYETEPDESMKSESMVMDDQLISSRPLGKRCLLKFVPVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJW7</accession>
    <name>A0A1C3YJW7_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CLP1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T16833</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJW7"/>
    <dbReference type="FunCoup" id="A0A1C3YJW7">
        <property type="interactions" value="832"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YJW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16833"/>
    <dbReference type="eggNOG" id="KOG2749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJW7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="11">
        <location>
            <begin position="23"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="12">
        <location>
            <begin position="132"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="10">
        <location>
            <begin position="346"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="135"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SCB64680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="452" mass="49059" checksum="7BD70F167BE5BEED" modified="2016-11-02" version="1">MSIPGLGQIPSQPTITATNRVVTLRPLCEWRFQTSQASPVIVKLLSGTAEKDGVELGPKNAYTFAGVKSKILTWHGCELEIDGRCDAESVAEYANPTDNPANTHMNLHGQLNDMRQAAAREGREGPRALIVGPADVGKTTLARTLTSYATRQGYQPLVVNANPREGLLSLPGTLSASVLATILDPEAVDGWGSTPTSGPSSVPVKLPLVFYYGQTSPDQDPDFYRELTSKLAGSVSARLSEDQDVKSSGVIIDGMGLTEQSKDGHELVAHIVDEFSVNVIIVVGSPAISSELSRRFGTERTSLGEPISVVPIDKSDGVVVRDEAFLQHVREAAIKEYFYGDSRRTLSPLIQQVDFDNVVVYHTSDEHSYPDQGITREDPCTPMQHWTLAVMNAAPKDAPDVVRAASVMGFLYVSDVDEERRKIKLLAPVSGRLGDQPLVWGKWPEPYINLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJX4</accession>
    <name>A0A1C3YJX4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T16529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16529"/>
    <dbReference type="InParanoid" id="A0A1C3YJX4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="335" mass="39088" checksum="6CFF5B8BE4D90F3E" modified="2016-11-02" version="1">MTNTLDLGVFLDGPSKNHDREKQTFVEELWRQPLVETHIEALSAYFELLKREVYALLDTKSFNLSSLDFEHVLTIRDAILRRHSDTQEVLRKEVAEQLKTLNLPNEAISLAIMFVIRLLLMIKVKQYNGTINAQSHLLQISDNQNLNGFPPWFNVIDLEKKAGLRIDWTHYITEHLTIQGDTLYLFCNIEALKHINGAQELTSKFFKEDFINETVRTVHLFFPETPHGYSSSQYLTWFHEHGEIKSWQRSLASLNTPTVSRLYNEYPVWNQRLAWVLEASKNQPNMGIKRIWQDDRDLSLWWTRWALITAVFLAVVFGLIQSITGIIQVVYAGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YL31</accession>
    <name>A0A1C3YL31_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FGRAMPH1_01T24603</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YL31"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24603"/>
    <dbReference type="eggNOG" id="ENOG502S16A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YL31"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SCB65248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="570" mass="64059" checksum="60B171C0C4D1375F" modified="2016-11-02" version="1">MVTSPTPTSPEFPDTNTPNQKGPASRACDRCRRRKARCVLRDLEDRCNGCRESGARCTFDLPISRRGPKARTRKSRSQGRGRGQTGENLTVELTASASNDSSAGWDSSAVHLGLSPSLMVSPVSVSVSSDATTSQQRWQDLSGALAFITNDLHHFVTRCFDLFFEYLYPLTPLVHEPSLRDSLSYFTQFPIARGTGLLELWPETTFTLITAVCAEAAFLLPKDLFPEGQSVADIFLNASRACLNQFLEAELESPNANSITIRYFHSNCLHAAGKPKYSWHIFGEATRLAQVMQLNLETSLEGLQPVEAELRRRAFWIVYMGDKSAAILNNRPITIHKFSFESGITTAYPSGIEDEAPVLSPGNLVTNSDVVRITCIEGFNANLRLWQNASDLLLELRLMHDRGHQDLGMANLQSLFSAQDKDRLDELYVRFITCLDDLPPYLQSYTFAALVDGSRETAKQFLIQCANLQVSIHCLRMVITQKLENLPFYKAEMGHSDLRKTEIARDMLRVIQEAPFWSLQVNGEPYVSRKDKTHWSESFGDYTQKWVFADCHESSERFYSSSRSPYSVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLE3</accession>
    <name>A0A1C3YLE3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T26269</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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    <sequence length="671" mass="74399" checksum="89605B1504494B0C" modified="2016-11-02" version="1">MRQNLFSSHSSSCTMLRLVPRCFFRLKAARSPFVIKPQTFRAFASVKASTSTSTSTIAHEPPKLQLRDYQEECIDSVLNSLQNGQKRVGVSLATGSGKTVIFTQLIERIPPASENAQQTLILAHRRELVEQAANHCQRQYPNKKIEIEMGNVHATGTADITVASVQSITSQGRLKKFDPSRFKLLLVDEAHHIVAPGYLKTLRHFGLDQKRPESPNLVGVSATFSRFDGVKLGAAIDEIVYHRDYVDMISKKWLSDVMFTTVETKANLSGIKKGTFGDYLPGELSKVVNTSEINDITVRSWMAKAEGRESTLVFCVDVAHVVELTDRFRQHGFDARYVTGETPKVERGQTLDSFRKGEFPVLVNCGVFTEGTDIPNIDCVILGRPTRSRNLLVQMIGRGMRLHPGKKNCHIIDLVSSLDTGIVTTPTLFGLDPNVLVERATVSDLRKIKETGQVNSEQPLSYHTTPGPGSGSVTFTDYDSVLDLIADTSGEKHIRAISKYAWVQVQGDKFILSAPDGSYVRIERVPERSNDSAPVYRAVEVRALLNGAKAPYAMPKEILTASTFTDAVHGADSFAAKAFPHTFIHRYQRWRSTPPTQGQVDFINKMRGKAEPLTIEDLNKGKAADMITKLKHGARGQFARIEAGQRKQDKQNKMAEAKRLREHVTVGPVAA</sequence>
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<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMG0</accession>
    <name>A0A1C3YMG0_GIBZE</name>
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        <name evidence="2" type="ORF">FGRAMPH1_01T11263</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YMG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11263"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB65696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="156" mass="17646" checksum="A5784D899C488BB0" modified="2016-11-02" version="1">MGIKDLAISYVVFTVIHFFLFALALATCGLYGTDVHHANQQGKYSDSKWVYAVVVGSISAVTCVLYFVPFVLRIAGVFVPVWDFILFVLWIALFGVFGKMYINEDAEGDGDVRRMKNAVWVDLASALLWFIAALGAFGYWWKHRDHRSRFTGRAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YML2</accession>
    <name>A0A1C3YML2_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FGRAMPH1_01T11331</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YML2"/>
    <dbReference type="FunCoup" id="A0A1C3YML2">
        <property type="interactions" value="564"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YML2"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11331"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YML2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14136">
        <property type="entry name" value="STKc_SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000409">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000076">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="59"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="218"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SCB65704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="524" mass="58427" checksum="F142A7AC94764A7A" modified="2016-11-02" version="1">MSSFLKSRSHQLSAMAHSPSSSSVEDAAENTADEEDSEDYCKGGYHPVQVGEKFKDGKYTVVRKLGWGHFSTVWLSRDNTNGKHVALKVVRSAAHYTETAIDEIKLLNKIVQAKPDHPGRKHVVSLLDSFEHKGPHGTHVCMVFEVLGENLLGLIKRWNHRGIPMPLVKQITKQVLLGLDYLHRECGIIHTDLKPENVLIEIGDVEQIVKRVVKPEAAEKENNRNGRRRRRTLITGSQPLPSPLNTSFNQSNLFPSPTPHSSLAGVLNDGKSSNEASPKPSDDAQKQREKSADLLSREVSGISLDKSNSPSTAAGDKRKAEDAHAFDVISVKIADLGNACWVNHHFTNDIQTRQYRSPEVILGSKWGASTDVWSMAAMVFELITGDYLFDPQSGTKYGKDDDHIAQIIELLGPFPKSLCLSGKWSQEIFNRKGELRNIHRLRHWALTDVLREKYHFKEEEAKRIADFLTPMLELVPDKRANAGGMAGHNWLEDTPGMKGLKIEGLEVGGRGEGIDGWSTEVRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YN17</accession>
    <name>A0A1C3YN17_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T13929</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YN17"/>
    <dbReference type="eggNOG" id="ENOG502SHR6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YN17"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SCB65874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="494" mass="55640" checksum="9497F526056B10F5" modified="2016-11-02" version="1">MKCDETKPECLRCVKDKRTCDGYEAPKRYKPRKKKKHQDDAPVVRQTQTSSRLLVPAGSPGTFGPPIELDLFHHFRTCTIAELTSSLNATSIWHTYVLPLSHEFESIKSAIGALGGAHKAFKLQTQTDSLTQSLAQSYELASIKQYNNAIQIMKQYMESPERNLQVVLTCCLIFICIESLYGRYMNVTRHLEAAFSLLNHDHISNYGAGTGTLSAQKDLEKFMENIGPSLCGLTSDLFFFMGDSQSSKLVSELQKWLHRQDPIYLKEPGAPFFSVQAAASWREQMETMNEAAMYTECPLCSSMGYPCGKDATVCSRFEHGLDTASFLRYWSARYSASNLTFDPSKASASDLSRFKVLELEETTWRARFKLNSIKGDLEAPDCMEILKKAESIIELSKGETGHIFNFQANLIPPIAYVIISCQDEKIQWEGVRLLRSLGRREGVWDSKKVAEIYANMITAKANKLLSWDDIPPDVPQLTELLSSLKLVTLPESQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YN58</accession>
    <name>A0A1C3YN58_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone deacetylase</fullName>
            <ecNumber evidence="3 11">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FGRAMPH1_01T15009</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 17">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3 11"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YN58"/>
    <dbReference type="FunCoup" id="A0A1C3YN58">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YN58"/>
    <dbReference type="ESTHER" id="gibze-i1rkc4">
        <property type="family name" value="Arb2_domain"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15009"/>
    <dbReference type="eggNOG" id="KOG1343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YN58"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070823">
        <property type="term" value="C:HDA1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990342">
        <property type="term" value="C:heterochromatin island"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070824">
        <property type="term" value="C:SHREC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140720">
        <property type="term" value="C:subtelomeric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031078">
        <property type="term" value="F:histone H3K14 deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902794">
        <property type="term" value="P:siRNA-independent facultative heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000005">
        <property type="entry name" value="histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019154">
        <property type="entry name" value="Arb2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017321">
        <property type="entry name" value="Hist_deAcase_II_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09757">
        <property type="entry name" value="Arb2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037919">
        <property type="entry name" value="HDAC_II_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="13">
        <location>
            <begin position="87"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Arb2-like" evidence="14">
        <location>
            <begin position="465"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SCB65946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="734" mass="82378" checksum="4BE507D63C3AFE8C" modified="2016-11-02" version="1">MEPNATDIVDHPMKDLDAPNGSYQTRNTSIDDDDTASEDPYEADVDPEPQDITFDQMRRRGLLPTGCCYDDRMKLHMNADFSPNTHHPEDPRRIHEIFKAFKKVGLVYTGPEAELPRIMRECPTRYMWRIPARAATREEICLAHSPEHFDWVERLDKMSTAELRDLTKQYDQGRESLYVGSMSYPAALLSAGGAIETCKNVVIGQVKNAFAVIRPPGHHAEWDGPMGFCFFNNVPVAVRVCQQDYPKICRKVLILDWDVHHGNGVQNIFYNDPNVLYISLHVYQNGIFYPGKPPNSMTPDGGIEHCGSEAGLGKNINIGWHDQGMGDGEYMAAFQKIIMPIAKEFDPDLVVISAGFDAADGDELGGCFVSPACYAHMTHMLMSLADGKVAVCLEGGYNLKAISVSAVAVAKTLMGEPPPRLELPKINKEAARILAKVQSLQAPYWECMRPGVVNVPEIQSLNSSRLHDVIRNAQRQVLQTKHNMIPLYIQRENLYKSYENQVLVTPGLHEAKKILIIIHDPPQLLAQPDVIDSTLDPHNAWVVDGVTDYIDWAIDQKFGVMDINIPAYVTHDEDSDAHIPSFKEQALTEQIQTLVCYLWDNHLQLYDADDIFIMGVGNAYLGVKVLLINRDCKSRITGVVNFANGTLRPIKSDIDTDLSSWYKENSRVFIAGDHACWADASLTKKVNKRRFGSVVRSPMFGLNKMMAHHAKEAREWILERLEGGSDADMTTEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1R9E4</accession>
    <accession>A0A098D0I2</accession>
    <name>I1R9E4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG00079.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T00241</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF71920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315675.1">
        <property type="nucleotide sequence ID" value="XM_011317373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1R9E4"/>
    <dbReference type="EnsemblFungi" id="CEF71920">
        <property type="protein sequence ID" value="CEF71920"/>
        <property type="gene ID" value="FGRRES_00079"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00079"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00241"/>
    <dbReference type="eggNOG" id="ENOG502S1A6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_1_0_1"/>
    <dbReference type="InParanoid" id="I1R9E4"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="BRENDA" id="3.5.2.B2">
        <property type="organism ID" value="2428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF71920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF71920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="413" mass="45400" checksum="1FEE7CC3E625694D" modified="2012-06-13" version="1">MSPIRLPPPVVIPESQSTVDVYIIDTTSFMSGFPASTFVEPLVPGFDTINVGSYAFLIKHNGSKPSKYDTVVFDLGVRKDWENLPETFVAGIKGSGCNINVETDVASILRDNGQDLNSVGGIIWSHWHFDHAGDPQTFPSSTDLIVGPGFKQGVMPGWPTAKDSHVNETAWQGRELVEIDFSGEAGLDIGKFQAYDFYDDGSFYLLSSPGHAVGHMSALARTTANPPSFMLLGGDIAHHCGEFRPSPYTPLPEMISPNPLGHTLSACPGRLFLSIHPWKDPERPFFDPTTEPGWHLEASIAKESIDKLVEADAYDNIFPVMAHDMTLGDTVDLYPKKANDWMSKRWKEETRWGFCGEFTPLDGETGAKKGNPAAPEGHHEVRDSAQDPKVASIVHMEYTDADKKAMLHDLTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RA08</accession>
    <name>I1RA08_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">FG00325.1</name>
        <name evidence="18" type="ORF">FGRAMPH1_01T00857</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="19">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="19">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315974.1">
        <property type="nucleotide sequence ID" value="XM_011317672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RA08"/>
    <dbReference type="FunCoup" id="I1RA08">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF72231">
        <property type="protein sequence ID" value="CEF72231"/>
        <property type="gene ID" value="FGRRES_00325"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00325"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00857"/>
    <dbReference type="eggNOG" id="ENOG502SBWQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142427_1_1_1"/>
    <dbReference type="InParanoid" id="I1RA08"/>
    <dbReference type="OrthoDB" id="5566853at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013958">
        <property type="entry name" value="DASH_Dad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08649">
        <property type="entry name" value="DASH_Dad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CEF72231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="106" mass="11687" checksum="A899920D029D9C5C" modified="2012-06-13" version="1">MASHSRSASAMGGHDKTYFEQQREALLGEIAMSFEHVLANINKLNRSLEAVTAVGNEFSSVEALWSQFENVMGKDEKAEGEAGQADQTERHDETMEGETTVKHEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1RAC6</accession>
    <name>I1RAC6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG00453.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T01171</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        <citation type="submission" date="2017-01" db="UniProtKB">
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                <consortium name="EnsemblFungi"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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    </evidence>
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        <source>
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            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
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                <person name="Ma L.-J."/>
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                <person name="Rep M."/>
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                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
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                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
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                <person name="Muehlbauer G."/>
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                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
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                <person name="Quesneville H."/>
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                <person name="Seong K.-Y."/>
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                <person name="Waalwijk C."/>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
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                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
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                <person name="Park J."/>
                <person name="Park S.Y."/>
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                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
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                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
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            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
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    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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        <source>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
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                <person name="Di Pietro A."/>
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                <person name="Baker S.E."/>
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                <person name="Goswami R.S."/>
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                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
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                <person name="Mauceli E.W."/>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316420.1">
        <property type="nucleotide sequence ID" value="XM_011318118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RB13"/>
    <dbReference type="EnsemblFungi" id="CEF72706">
        <property type="protein sequence ID" value="CEF72706"/>
        <property type="gene ID" value="FGRRES_00714"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00714"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01811"/>
    <dbReference type="eggNOG" id="ENOG502RXYE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029564_3_0_1"/>
    <dbReference type="InParanoid" id="I1RB13"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF72706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="430" mass="48768" checksum="2E8569F9AA961599" modified="2012-06-13" version="1">MSVMTTRLDSRKSLLGADNGYGYGHSYNNSYDNSYAPSPVPSPQPIPQPPAFQAAVEPTYNQGFAYREGLTPSVPSQSMKNGKIDFMKSRWPACFMAVSLLQAILCICFEAYIFGKFQVNLGTHNPDPEVQSQYKTIPTFLTLFIFGFLYTLVVVWDALRQKNTIQIIGVCFSNLALMVYTTIQVDQIKEAFDILGEHSALRPEMPATELWHDVKPYLVAIPAIIALATLVMGFLSWKIYQEYAWDILKNIGADYRMKKRFLHYQIYIALLKFDFFFFLGFIVQFVVVVADKDDPEFALTIVTIPITILILLAAAFFTRRENKAGMIAIVVLYLGGLSYFIFKLVRIYQPGHKQNYEAVRRSLTAFAVITILLIILTIINAIVCMLNFGKGLKPHLQALSRKRKVEEKPDVNSINMQDVKPQIPSRMTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1RC25</accession>
    <accession>A0A098D2M0</accession>
    <name>I1RC25_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG01126.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T02803</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316893.1">
        <property type="nucleotide sequence ID" value="XM_011318591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RC25"/>
    <dbReference type="EnsemblFungi" id="CEF73203">
        <property type="protein sequence ID" value="CEF73203"/>
        <property type="gene ID" value="FGRRES_01126"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01126"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02803"/>
    <dbReference type="eggNOG" id="ENOG502SHF3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005049_1_2_1"/>
    <dbReference type="InParanoid" id="I1RC25"/>
    <dbReference type="OrthoDB" id="3057168at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF16">
        <property type="entry name" value="DUF2235 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="31"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF73203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="581" mass="64277" checksum="E1932BB053E68D40" modified="2012-06-13" version="1">MPSEPQVSKGFIPLEDGSHHEATEDAQAAPKRIVICCDGTWQSSVSGLKNIPSNVTRLARSIARSGKDKDGKVWQQVVYYDAGIGSGDLGQAEANRQGGTGIGFVGNVIEAYNFIVLNYNLGDEIFCFGFSRGAYTARAVAGLVTDIGIVCPRDLQDFPDLYALYQKNPDGLHFRKSQAYLEWVNGVPSKKQANGGSQIPSAWDSPPHHDAPEPSRFVKVVGVFDTVGSLGIPDLPWTRFNLKFLEKTIGITEPGFHNIHLSPYIQHAYHALALDEHRGPFSPSLWHLPTNKDQAPKPDKDVKELWSDWEKVYKTPNASKKELQEAWGAVVDGEMHEQLRDNRSELLQVWFPGVHINIGGGNDDPLTDKKSDFEQIALISFGWMCEQVAPFLEFAEGGSLGDLGKSAVQDRYNLLKPLLTNIQNGDEKDYGGGLVTSRIAASLDRTGIRKAEVRKVPEETISGWATGPIVDSFTGAMIASGSVDRTPGNYSKDDKGRELGETYEMIHPCVKYRMNKVSSYKPKALRGYERTADGKKGYVWKKGNVQIPEFVIKTEDAFSRYVAEQDRYATEFIKSLDNVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RCP9</accession>
    <name>I1RCP9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG01373.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T03387</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03387"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RCX1</accession>
    <name>I1RCX1_GIBZE</name>
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        <submittedName>
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    <gene>
        <name evidence="4" type="primary">FG01454.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T03575</name>
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    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
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    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_011318958.1"/>
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        <property type="gene ID" value="FGRRES_01454"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="TF_kinase-domain_protein"/>
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    <dbReference type="PANTHER" id="PTHR44305">
        <property type="entry name" value="SI:DKEY-192D15.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44305:SF24">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE C03B1.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="102"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF73593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="604" mass="67532" checksum="8E0B39D873CF92C3" modified="2012-06-13" version="1">MGQWWVDSRIEATVTRSYVASQLLPDEVERLDRPVAFGGEDLTERTYWESIRNDAPRLFLILVDLGVPDQIFGVVDDGWDDAELPIALEDVDRLLLTATRDEKVEKKFYQRQFHFLLKPLQRGNHVTYKDNEVVPLDVVEKPSLPTHKSNGHDKVRLPNIPGETFCRRRYVLGNGPGAVPMQDFLDAVHGIKGLQNEHMISYWASYTQHGCGYVLFTPSSDFTLKSFLATTPSQFKNLAKARRRELIMNWILCLVDTLCDFHSKNQSHGYIKPSTIFFTNQNHVFYSDSTRLTPDNVILHTDKSSFDRERYDYAAPELWSRPAGATSPSHRYPSSDEGHFGMIQTYDPNGSPNTMFIAPSPQYSGQQADIFSVGCIILELLSYLVKRTSSKFASFRSAKHKTAGRGGAVLDTSFHKNLGQVELWMSGLAKDATRKSTSTKDGANILKGVHPMLHVVTGMLAMNPYDRPPAIEVQQRIYQILTDICNISEPHCVHQYSQDLEASFGGLQIHPMGDGPVGSLPGGSNTTYGTPRTYQHSRNGSSGGYSQVSRTTGSSEADMEAIHQVGSVGLHQVRTQNSWPRNVAYSQYAGVSQYSAGQWDSHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I1RD13</accession>
    <accession>A0A098D3Z5</accession>
    <name>I1RD13_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG01500.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T03675</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317309.1">
        <property type="nucleotide sequence ID" value="XM_011319007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RD13"/>
    <dbReference type="EnsemblFungi" id="CEF73643">
        <property type="protein sequence ID" value="CEF73643"/>
        <property type="gene ID" value="FGRRES_01500"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01500"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03675"/>
    <dbReference type="HOGENOM" id="CLU_2236821_0_0_1"/>
    <dbReference type="InParanoid" id="I1RD13"/>
    <dbReference type="OrthoDB" id="10454430at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF73643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="105" mass="11774" checksum="7BFEAEDBF0F81BE0" modified="2012-06-13" version="1">MDRPKIALEAIIILGTGTFGLQWFNGGGALAWEVEVGHSRQAGDSLRYTVSKYLWRLDFLMTVKVPSRVLLSIKLVLFSNEPTHHHKLNSTVNNNNTFSKGAEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I1RD37</accession>
    <name>I1RD37_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG01526.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T03729</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317336.1">
        <property type="nucleotide sequence ID" value="XM_011319034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RD37"/>
    <dbReference type="FunCoup" id="I1RD37">
        <property type="interactions" value="465"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RD37"/>
    <dbReference type="EnsemblFungi" id="CEF73670">
        <property type="protein sequence ID" value="CEF73670"/>
        <property type="gene ID" value="FGRRES_01526"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01526"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03729"/>
    <dbReference type="eggNOG" id="KOG0064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007587_1_1_1"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:peroxisomal membrane"/>
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        <property type="term" value="F:ABC-type transporter activity"/>
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        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
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        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC1_TM_dom"/>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="527"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="747"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF73670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="810" mass="91382" checksum="2560D4DBA677787D" modified="2012-06-13" version="1">MAGQSTLRYTAAEEQLAAFLDKWTGKIKSRLRGTTRTTRLLATLALAISIILGGAGGRRWWKNRRHEREQGRKLVRTNSWLHNKDGSRTIYVPYKDSTSKVVINTTKPLTFDAHRRLFLNPPRVSGLREGTVPAAQTKPGLNIAFLHQFLSLMSIMIPRWSSKEAGLLVSHGAFLMLRTYLSLVVARLDGEIVRDLVAGNGRAFLWGILKWCGIGGFASYTNATIKYLESKVSIAFRTRLTRYIHDLYLNDNLNYYKLSNLDGGVGQGADQFITQDLTLFCASAANIYSSLGKPFVDLCVFNYQLYRSLGPLAITGLMSNYFLTASILRRLSPPFGKLKAVEGRKEGDFRSLHARLIANAEEVAFYGGAETEKTFLNREFKSLKTWMEGIYMLKIRYNILEDFILKYSWSAYGYLLASLPVFLPAWGGVGGRAEMVENGVRGGRERNRMKEFITNKRLMLSLADAGGRMMYSIKDLSELAGYTSRVYTLISTLHRVNADAYQVRAGQSELYSLSDVSGTIQKGFDGVRFEHVPVAAPGLWPQGGEELLESLSIIVRRGEHLLISGPNGVGKTAISRILAGLWPVYRGLVSRPKDIGQDGIMFLPQRPYLSPGTLRDQVIYPDGHVDMKEKRKSEDDLIKVLEAARLGYLPDREGGWDTRKEWKDILSGGEKQRMGFARLLYHEPQYAIVDEGTSAVSSDVEGLLYETCKEKGITLITISTRASLKKYHEYNLVLGMGDRGDEWEFERIGTEREKMQVEKELQELRERLTQVDEWKKRRDEIETELSAVWTEQGEVLEAPTYAEKVAEVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RD43</accession>
    <accession>A0A098D6X2</accession>
    <name>I1RD43_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG01532.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T03741</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317342.1">
        <property type="nucleotide sequence ID" value="XM_011319040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RD43"/>
    <dbReference type="STRING" id="229533.I1RD43"/>
    <dbReference type="EnsemblFungi" id="CEF73676">
        <property type="protein sequence ID" value="CEF73676"/>
        <property type="gene ID" value="FGRRES_01532"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01532"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03741"/>
    <dbReference type="eggNOG" id="ENOG502RMBV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_622622_0_0_1"/>
    <dbReference type="InParanoid" id="I1RD43"/>
    <dbReference type="OrthoDB" id="5099825at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF73676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="496" mass="53827" checksum="5F27B89E0251F084" modified="2012-06-13" version="1">MPGSIKSLKRKPTAKSAAKRIGRMFKRTNSEDPEMTAAMDIGSPKASFDAPRPSTSSRFSISSRMTSRDDAEATPRGSKDQSRVFASWFEPSTPKKEKGPQAVAPPPLVSAYSEPILDHVKPLEPMVPVESIEPPKTEGFPFPAPPQTDHEPKATDTTPKKQIEPLRQPGKVDIKAPEQPVLVPTTPQASRPLPSPPVARPVIYEPESPILPAVSRAEPEQKPIPTPTDKSKIIPKTELGYEQKNTAQPKPTAKTTPKTEPAEQQDISLPKMRHPSKSPDLPEQVPKSHITTARKTSMPRPTVEDEPQIMKPAKATKEHSRKDRKTRLETVPKTEPKSLPSKPPRKETKSKAQLPVISENRVPAPIAPEAMRKHAEPKDSVKALAAPSIPSPAKISSIPALAPTYVPKAATYTAKHSFAPSILFQPSRIVYFPDTAPAPKTVRPPITARAPIIASKPEVVVSILTRAAPKSVPAPSIASTPVRAHSPLTSWIMSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RDW4</accession>
    <name>I1RDW4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG01832.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T04431</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317674.1">
        <property type="nucleotide sequence ID" value="XM_011319372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RDW4"/>
    <dbReference type="STRING" id="229533.I1RDW4"/>
    <dbReference type="EnsemblFungi" id="CEF74022">
        <property type="protein sequence ID" value="CEF74022"/>
        <property type="gene ID" value="FGRRES_01832"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01832"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04431"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_13_1_1"/>
    <dbReference type="InParanoid" id="I1RDW4"/>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF10">
        <property type="entry name" value="NAD(P)-BINDING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF74022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="283" mass="30478" checksum="D11FCD4132CD42CC" modified="2012-06-13" version="1">MAEFVIQDDKLSALKGKVVIVTGGSSGIGLSTVEFLLSLGASVVNGDVQPPQKQHEGPFTFVKTDVSVWADLVALFKKAKEVYGRIDHVFANAGLGPRADYLSTQVDDNGDLIEPTHALMDVSLKGVVNTCTLAIYYLRQQAEGGSIVISGSTTGLQRVRAVDYSTAKHGVIGWGRGLVPLLDAAKLPIRVNTLAPSWTESSVLPELKMLLNAINVELQPASVVSRCAAFLMADESKNGQLVHIERGKYAEIDEAILLPAFGKIKSDDYPFEDDVLRRLSELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1RE22</accession>
    <name>I1RE22_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
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    <gene>
        <name evidence="3" type="primary">FG01895.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T04579</name>
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    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317744.1">
        <property type="nucleotide sequence ID" value="XM_011319442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RE22"/>
    <dbReference type="STRING" id="229533.I1RE22"/>
    <dbReference type="EnsemblFungi" id="CEF74096">
        <property type="protein sequence ID" value="CEF74096"/>
        <property type="gene ID" value="FGRRES_01895"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01895"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04579"/>
    <dbReference type="eggNOG" id="ENOG502S34X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030082_0_0_1"/>
    <dbReference type="InParanoid" id="I1RE22"/>
    <dbReference type="OrthoDB" id="422106at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
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    <dbReference type="PANTHER" id="PTHR16291">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR16291:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF10309">
        <property type="entry name" value="NCBP3"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
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        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF74096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="403" mass="44737" checksum="2A7528F467B7CED3" modified="2012-06-13" version="1">MDLDIEMDDAVETGQDLPVVDLGRDDILQHDELEEPGEVAEDEPATDDSKTLVPTKIHIKGVDSLHTSDIKAYVKSHFGDVDRVEWIDDSSANLLFPSEPTARDAIVALSSVPVADATALAIGETLPAKPFDAKPEISLQVRFAVSSDRKEQGAALRSRYYLLHPEHDPEERRRKNQENRSRYRERDGGYRGDGGRRRRASDDDIETFEASMYDDAPRPARRRDSDIEERPRSYTRQNEGKELFVGRKKQRDRSASPRRDRDGDDLMDRRASSSGNRVKARDLRDRISTGNKSKELFPTKKSIKQFGGGNLDTLEQAIGSARLKDEDRPKIVSAPGARGDGSSFNIRGMANQQGNGEGFAIKGAAGANARELFPTKLGGNNAGKELFGGGRTKQRQKAEDLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1REG4</accession>
    <name>I1REG4_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG02052.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T04951</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317925.1">
        <property type="nucleotide sequence ID" value="XM_011319623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1REG4"/>
    <dbReference type="STRING" id="229533.I1REG4"/>
    <dbReference type="EnsemblFungi" id="CEF74282">
        <property type="protein sequence ID" value="CEF74282"/>
        <property type="gene ID" value="FGRRES_02052"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02052"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04951"/>
    <dbReference type="eggNOG" id="ENOG502R0UW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037440_0_0_1"/>
    <dbReference type="InParanoid" id="I1REG4"/>
    <dbReference type="OrthoDB" id="5106710at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124082" evidence="2">
        <location>
            <begin position="20"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF74282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="610" mass="62289" checksum="E116419661774D02" modified="2012-06-13" version="1">MSLLARFALVGLWAFAAYAQSDTVTVTETVTECAASCYSVVSQCTSTEYIETSSIIKLPTESSVIVSETSLIETTEVISLPTVSVASTISKFANTSAVTGSYTSTSTVSGFETTITISESSGVSVGSSALAGETSESESESSLYGYSTTTLALTEATTETVTNIETLPTIVPSVDSSALASGTTQLSETSESSIVTQGSTEQSSESTPLSTESVSTESTTTDRIVPQQSKSTETEGTEASTATEASTATGASTATEEASTATLTSVLTSQVTFTETISTVYSSSAEESVTSEESTEFVVTSSQIEESSSGTEQGSVTTEVITSEVTGITQVTSSVTLTSIETLTVSESTSSSGETTEASISESSGTSASTASESEVKTVTSIETVTAETSASQTDSTGSGSSPGSTSAGVSTGTTEVEESTTTTCTSTRHTHSYENTTIVHSTADVSIDSSALAGSFTSTLSEGTSVTSGVVEQTTLPTAETETGTTTGGTASGVETTESISIESSASQSTAATTPVSLPVEPTYPPHNYDFGAPSSADDGWPTFSVDSSADAATGFSSFTTLVTTSKATDTTSTSTSTGIKEPYYEPPAYEPPSYRESAYVRKRWGFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RF01</accession>
    <accession>A0A098D6E6</accession>
    <name>I1RF01_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG02262.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T05459</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318166.1">
        <property type="nucleotide sequence ID" value="XM_011319864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RF01"/>
    <dbReference type="STRING" id="229533.I1RF01"/>
    <dbReference type="EnsemblFungi" id="CEF74534">
        <property type="protein sequence ID" value="CEF74534"/>
        <property type="gene ID" value="FGRRES_02262"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02262"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05459"/>
    <dbReference type="eggNOG" id="ENOG502SKUZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054797_0_0_1"/>
    <dbReference type="InParanoid" id="I1RF01"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08023">
        <property type="entry name" value="GH16_laminarinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF53">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="64"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF74534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="322" mass="36431" checksum="33E7BFAE7845C7DD" modified="2012-06-13" version="1">MAWKDHLKRLKNEFQSLVGEPEAQNQNQNQNQNQQYYPPPPPPPQEQQQQPMGGGQNQSQQGHVYWQPQFRPDAPVTSEWDAKIGNGPDGWGNQELQHYTADQQNAFHTPDGKLVLRAIANNAESNHEKRYTSARLVSRQTLSRDQGVLTAWLTSPCATGIWPAFWLLPQEPFSWPTDGEVDIAETWNGDLENHSCLHWGHHHEPDKHRVLGTKIPDMQYRPVRYDLAWLQPGGQAGQGRMVWYIDGRPVMKGEIPAGTRPMRDMNILLNVAMGGNVCGGKTPSDGQYDMVVHSLYMGSEPEHGGWHRFESDWAAAPMGNTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I1RF87</accession>
    <name>I1RF87_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG02354.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T05657</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318263.1">
        <property type="nucleotide sequence ID" value="XM_011319961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RF87"/>
    <dbReference type="STRING" id="229533.I1RF87"/>
    <dbReference type="EnsemblFungi" id="CEF74633">
        <property type="protein sequence ID" value="CEF74633"/>
        <property type="gene ID" value="FGRRES_02354"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02354"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05657"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031465_1_0_1"/>
    <dbReference type="InParanoid" id="I1RF87"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF337">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124169" description="chitinase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="7">
        <location>
            <begin position="18"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="6">
        <location>
            <begin position="302"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF74633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="430" mass="47191" checksum="61E91A62770CEC30" modified="2012-06-13" version="1">MHLSALLGLGAAAVTSASRNIIYYDQWHTKDLPSKDITSGVTHVMMSFANSSLFTTQPGGKYEPFQPLEKVRSLFDHDIKVCLAVGGWGDNAGFDEGVKTDRSRERFARNVASTLDRLGFDCVDIDWEYPGGNGQDYKQVPNSKKTYEIKAFPKLLKEIKKFIGEKELSIAVPGLERDMIAYLPTEAPLINKYVDFVNVMTYDLMNRRDHYTTHHVSIAGAARAIDKYISLGFPPSKLVLGIPFYAKYFMTKKGYTCTEPIGCPTELLENPEDGSDTGKSGSMTFEAANFAAAPTNLTTSTDATCGAGTFFKCPAGSCCAASGWCGSTPAHCGTGCQSAFGKCDGVDINNSFHKALKDGRTDTVNGGQWYWDSETRIFWTWDTAELIAQKIAFMAQTRGVKSVMAWALALDSNDWSHLKAMQQGFKDVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I1RFJ1</accession>
    <name>I1RFJ1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thiamine thiazole synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Thiazole biosynthetic enzyme</fullName>
            <ecNumber evidence="6">2.4.2.60</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG02469.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T05923</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + nicotinamide + 3 H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:55708"/>
            <dbReference type="Rhea" id="RHEA-COMP:14264"/>
            <dbReference type="Rhea" id="RHEA-COMP:14265"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:90873"/>
            <dbReference type="ChEBI" id="CHEBI:139151"/>
            <dbReference type="EC" id="2.4.2.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">During the catalytic reaction, a sulfide is transferred from Cys-211 to a reaction intermediate, generating a dehydroalanine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the THI4 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.60" evidence="6"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318395.1">
        <property type="nucleotide sequence ID" value="XM_011320093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RFJ1"/>
    <dbReference type="FunCoup" id="I1RFJ1">
        <property type="interactions" value="868"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RFJ1"/>
    <dbReference type="EnsemblFungi" id="CEF74766">
        <property type="protein sequence ID" value="CEF74766"/>
        <property type="gene ID" value="FGRRES_02469"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02469"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05923"/>
    <dbReference type="eggNOG" id="KOG2960">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053727_0_0_1"/>
    <dbReference type="InParanoid" id="I1RFJ1"/>
    <dbReference type="OrthoDB" id="410463at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160205">
        <property type="term" value="F:cysteine-dependent adenosine diphosphate thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052837">
        <property type="term" value="P:thiazole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03158">
        <property type="entry name" value="THI4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027495">
        <property type="entry name" value="Sti35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002922">
        <property type="entry name" value="Thi4_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00292">
        <property type="entry name" value="sulfide-dependent adenosine diphosphate thiazole synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422:SF3">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01946">
        <property type="entry name" value="Thi4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="105"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="290"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="2,3-didehydroalanine (Cys)" evidence="6">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF74766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="322" mass="34846" checksum="D5CA1BD54A559DD2" modified="2012-06-13" version="1">MSPPAAISPTSRSVELATSTTKLPVHAVKNINTKTVEEMLGNWDDFKFAPIRESQVSRAMTRRYFQDLDNYAESDIVIIGAGSCGLSAAYILGKKRPDLKIAIIEASVSPGGGAWLGGQLFSAMIMRKPADAFLREVGVPYEDEGNYVVVKHAALFTSTIMSKVLQMPNIKLFNATCVEDLITRPSDEGIRIAGVVTNWTLVSMHHDDQSCMDPNTINAPLIISTTGHDGPMGAFCVKRLVSMQRIEKLGGMRGLDMNLAEDAIVKGTREIVPGLIVGGMELSEVDGANRMGPTFGAMALSGLKAAEEALKIFDTRKKQNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RG59</accession>
    <name>I1RG59_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG02708.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T06489</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318662.1">
        <property type="nucleotide sequence ID" value="XM_011320360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RG59"/>
    <dbReference type="STRING" id="229533.I1RG59"/>
    <dbReference type="EnsemblFungi" id="CEF75049">
        <property type="protein sequence ID" value="CEF75049"/>
        <property type="gene ID" value="FGRRES_02708"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02708"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06489"/>
    <dbReference type="eggNOG" id="ENOG502RA80">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039657_1_0_1"/>
    <dbReference type="InParanoid" id="I1RG59"/>
    <dbReference type="OrthoDB" id="5387995at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF75049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="406" mass="45099" checksum="581B7E47C60474A8" modified="2012-06-13" version="1">MEVEANAQSSINLLEPWRCHAKGGCHDDLPVSPLDLSSDDLNQVPRCPGPDPLFEALMGDAAYHTLGKPESSKATQEKKTTRSKAWISQTEPETSTGFSFPSSDEANTRFGPLSIQIRPASTIPQGLKRRRYISDVDGFNTGDLSVKKRRLRADLITSRLSQPYSQPATHILNREGQEAGDKRFLKMATSVDMTRRIAHLHATSFLRFSLMNCLRQRLSQEQPVRKHEQEIAAITSKVTSKSSLKPPTLQDLAASRSLRIAPTCSGLAGPQGLISSTKPQPNHQAPKSFQHSKPTSCRLSKPAALPLPVGDVAATKKRTSPRLFPIRSPELRPTVHVPPLDDLEEDSFAYMHPAYDDWDDAGNDQDSVYSDFSVVFGQNGENSNEEEDRSYEEYLDELDGICWMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I1RGK2</accession>
    <accession>A0A098DF03</accession>
    <name>I1RGK2_GIBZE</name>
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        <submittedName>
            <fullName evidence="8">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG02872.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T11509</name>
    </gene>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322934.1">
        <property type="nucleotide sequence ID" value="XM_011324632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RGK2"/>
    <dbReference type="STRING" id="229533.I1RGK2"/>
    <dbReference type="EnsemblFungi" id="CEF77558">
        <property type="protein sequence ID" value="CEF77558"/>
        <property type="gene ID" value="FGRRES_02872"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02872"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11509"/>
    <dbReference type="eggNOG" id="KOG0684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018012_4_2_1"/>
    <dbReference type="InParanoid" id="I1RGK2"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053007">
        <property type="entry name" value="CYP450_monoxygenase_sec-met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF77558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="550" mass="61112" checksum="16BC392E206E107B" modified="2012-06-13" version="1">MDSHSSSFLGQTFLDLRNGDLSSSSAWTTAAIATAIALSLLNYFLTPRLDPREPPVVKPTIPWIGHILGIIRHQADYGRLIHNANPNHQIATLPMLNGKLYAVFDPSLLQSLLRNKTASFEPFAIDYAKKTFDLTQEEFLKVKAPGVYDEFTDAIHASFQTVSLHQMNVHFLACISAKLDPMSNGTMRAHADTHGKEKVTNGQLQVENLYLWCRDVMSLATTKALYGDTDPFGSKPDLIEDMWCFEESVPYFLLSLYPSITMPKAYKARSTLQDIVCKWYSEDHDVTDPSVSAIVRNRAGSLRKNGLIGSEIGKFEVILPNVATLNAVPTFYWLLLYILDRPELVARIRSEAEAAAVIAHDNGKKTVTFNIAEYEAKLPLLVSCYRETMRLVNQSVSMRRILEDITVTTPEGNTYLLKKGTDMQLPAGVAHYEQSVWGSDVNTFDPERFHPGSKGSPEEERKRKAAYIPFGGGRHLCPGRNFAFAEIIGFASSLLLGFDVEATGMGFGDMKKLGPQLAGGTVRPEKYGSGLGAQIKSRQGWGNVQWKFEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I1RHI5</accession>
    <name>I1RHI5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG03239.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T12397</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322513.1">
        <property type="nucleotide sequence ID" value="XM_011324211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RHI5"/>
    <dbReference type="STRING" id="229533.I1RHI5"/>
    <dbReference type="EnsemblFungi" id="CEF78001">
        <property type="protein sequence ID" value="CEF78001"/>
        <property type="gene ID" value="FGRRES_03239"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03239"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12397"/>
    <dbReference type="eggNOG" id="ENOG502S4C3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105924_0_0_1"/>
    <dbReference type="InParanoid" id="I1RHI5"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF37">
        <property type="entry name" value="LD18367P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF78001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="200" mass="22614" checksum="9F134CD0B1D619EE" modified="2012-06-13" version="1">MTNSARSISIEPGYRPGLLARCLEMHITHYHPVNSWGLAFETSVAAAWADLIQRLETNPRNQVFAAVQETDDPAAFTQKIVGTILVDAENMKQPGTAQIRGFIVDERARGLGVGKKLLNAAMEFVQEQGFDRVSLYTSRTQETSLFLYNKAGFQIVEDVEKDLWGWKTNELQLQWTRPDLLGRTVEGDSRKRDSNIEKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1RHS6</accession>
    <accession>A0A098DGN8</accession>
    <name>I1RHS6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG03339.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T12643</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322394.1">
        <property type="nucleotide sequence ID" value="XM_011324092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RHS6"/>
    <dbReference type="STRING" id="229533.I1RHS6"/>
    <dbReference type="EnsemblFungi" id="CEF78124">
        <property type="protein sequence ID" value="CEF78124"/>
        <property type="gene ID" value="FGRRES_03339"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03339"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12643"/>
    <dbReference type="HOGENOM" id="CLU_134552_2_0_1"/>
    <dbReference type="InParanoid" id="I1RHS6"/>
    <dbReference type="OrthoDB" id="3439489at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF78124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="130" mass="14757" checksum="ACCAAF13EAA423BD" modified="2012-06-13" version="1">MSTLPDHFTITVDGKHVAKPEQKSEEMFQAEAGDEPAVFELKGDRLVSGDFSLGRWIVEDMSSHPKPIMWRKNEEESRDLRPVTVTHSINGPEIRFHDSQGIAIHDGKLFAIMDQNKEESQSVEIRAVEE</sequence>
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    <accession>I1RI17</accession>
    <accession>A0A098DIJ4</accession>
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            <fullName evidence="1">Chromosome 2, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Sordariomycetes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322282.1">
        <property type="nucleotide sequence ID" value="XM_011323980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RI17"/>
    <dbReference type="EnsemblFungi" id="CEF78242">
        <property type="protein sequence ID" value="CEF78242"/>
        <property type="gene ID" value="FGRRES_03437"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03437"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12879"/>
    <dbReference type="eggNOG" id="ENOG502RNZN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_733721_0_0_1"/>
    <dbReference type="InParanoid" id="I1RI17"/>
    <dbReference type="OrthoDB" id="5087840at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF78242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="385" mass="45377" checksum="1DDA2189D91C3689" modified="2012-06-13" version="1">MAPPNVIQGWHKLPQELRLEILKFALTPPIERPAPSNIQPDCLGSPRCRRVREWGPKNLAKDLLLVSRQFHDDVQHIIKFMPNIYHLDIMLIANYGAWFTWYLPKQPTSIYIDEVIVAVRIFERPDDVYDCYKDAPDYMRRFPHPEWTFHATVLFFMCIGPRLLYEYNYGRIVVKKFDVNVLSGLGHRLDEDQFLTSIVFPLEFMTNSDRHFCAFIVLNYKYLVEGIVLRLSGFEYRRLDFERIIIDMQSSARVRMRKSLSQILEEREKTKKRFEKYCHRAQIQRGQALVTRSAHKLNQLRDSLRQETNGLLHAFPTQSHDRYKTSQKIRNNHDFKDLLKLAICHIKNDGIVPDDEMTAETLGEGLQAYKTEPEAFAKEALELIY</sequence>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I1RIT7</accession>
    <name>I1RIT7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
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    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321961.1">
        <property type="nucleotide sequence ID" value="XM_011323659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RIT7"/>
    <dbReference type="EnsemblFungi" id="CEF78589">
        <property type="protein sequence ID" value="CEF78589"/>
        <property type="gene ID" value="FGRRES_03731"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03731"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13571"/>
    <dbReference type="eggNOG" id="ENOG502QZ63">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049199_0_0_1"/>
    <dbReference type="InParanoid" id="I1RIT7"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF6">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF78589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="346" mass="40227" checksum="19146EE858E97A1C" modified="2012-06-13" version="1">MSTTVTVEPTQTVAARFETKDLVEFDPNAVYGDWRDEFHKTGCVVIKNVISPERAQYYCDKQIEWLKKFELGFDDKDPSTWNADHLPVSFKGGMYYGYGATHEKMAWEARTEPKVVEIFEKLWETKELLCSFDGLNISLPNRTDITWSPWPHCDQNPERKGMQAVQGLLNFAPNGDKDGGLVLMKGSSKLFNEFFAHKRESADHEDAPPPEIKYMDLFLFSKKDVKWFEDRGCEMYKVNMEPGDFVLWDSRTMHYAKFPEGDQIRHVQYVCMTPRKFATEEALKAKAYCFETFTGTTHWPHCNIRIAQEKPMRNGEICPKYRTEPFEKPEVTDQILRLAGVKSYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJV4</accession>
    <name>I1RJV4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG04137.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T14579</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321494.1">
        <property type="nucleotide sequence ID" value="XM_011323192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJV4"/>
    <dbReference type="SMR" id="I1RJV4"/>
    <dbReference type="FunCoup" id="I1RJV4">
        <property type="interactions" value="994"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RJV4"/>
    <dbReference type="EnsemblFungi" id="CEF79092">
        <property type="protein sequence ID" value="CEF79092"/>
        <property type="gene ID" value="FGRRES_04137"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04137"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14579"/>
    <dbReference type="eggNOG" id="KOG0878">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071479_4_0_1"/>
    <dbReference type="InParanoid" id="I1RJV4"/>
    <dbReference type="OrthoDB" id="268693at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_eL32_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF79092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="131" mass="15033" checksum="75C7DAFEB2141893" modified="2012-06-13" version="1">MVSAKKHVPIVKKRTKRFERHQHDRFMRVSPSWRKPKGIDSRVRRRFRGTIAMPSIGYGSNKKTRYMAPSGFKAFIVSNKSDLELLLMHNKTHAAEIAHNVSSRKRVDIIARAKQLGVKVTNPKAKVTTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>I1RKP1</accession>
    <name>I1RKP1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Superoxide dismutase</fullName>
            <ecNumber evidence="3 10">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG04454.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T15331</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="3 10"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321146.1">
        <property type="nucleotide sequence ID" value="XM_011322844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RKP1"/>
    <dbReference type="FunCoup" id="I1RKP1">
        <property type="interactions" value="600"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RKP1"/>
    <dbReference type="EnsemblFungi" id="CEF79467">
        <property type="protein sequence ID" value="CEF79467"/>
        <property type="gene ID" value="FGRRES_04454"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04454"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15331"/>
    <dbReference type="eggNOG" id="KOG0876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031625_2_2_1"/>
    <dbReference type="InParanoid" id="I1RKP1"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
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    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
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    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
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    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
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        <property type="entry name" value="Mn/Fe_SOD_N"/>
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        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="11">
        <location>
            <begin position="37"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="12">
        <location>
            <begin position="126"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF79467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="230" mass="24963" checksum="310623D5993703C9" modified="2012-06-13" version="1">MASALLRSTPALRAGLRARSTPLAAMATTSFVRGKATLPDLPYDYGALEPYISGQIMELHHSKHHQTYVTGFNNATDAIAEANHKGDAKAAAAQAPLLNFHGGGHVNHSLFWENLAPNGKGGGGEPEGKLLTSINEDFGSFEAFKKQTNATLAGIQGSGWAWLVKDKNAGTLSIVTRPNQDPVTGNLEPLLGIDAWEHAYYLQYQNRKAEYFSAIWDVINWGTVAKRFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RLF0</accession>
    <name>I1RLF0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG04746.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T16219</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323187.1">
        <property type="nucleotide sequence ID" value="XM_011324885.1"/>
    </dbReference>
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    <dbReference type="STRING" id="229533.I1RLF0"/>
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        <property type="gene ID" value="FGRRES_04746"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16219"/>
    <dbReference type="eggNOG" id="ENOG502RWKT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_834163_0_0_1"/>
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    <dbReference type="OrthoDB" id="5403091at2759"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="entry name" value="OpdG"/>
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    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF87358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="351" mass="39498" checksum="9CC3BC9AF6A1654B" modified="2012-06-13" version="1">MNSLREALLAPSPKGISQQELLKSMSRDEEDVLQAVARGEFEELRGMARYNRTWNISNSYCSVGDGVDSLEGNLHSIWHVYYQLSRHASHETAEHDRLVLDIVRFQGLGPLTRPVSGSYGIDIARTTEGTLWNDLPFLVSDMTKFWMDNCATLSGAHRLNFASFLAKLASTRVSNDKMSQIALLLFRSVFEDARDLGTAGDADDEDKKRDMRDLTIAQLLPSASVWINEAGYNIIQLSDVSWNDCPSPVGHGGPMFTQSDLGKRCPNGFTPWRWMFWLKRLHKIRDEAKEANENGLEESAVEAIEAMVSNVEERNSEILRAYQDGGEDLHKDQHFSCLQGLLKSHTENTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RLG0</accession>
    <accession>A0A098E3U3</accession>
    <name>I1RLG0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG04757.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T16245</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323199.1">
        <property type="nucleotide sequence ID" value="XM_011324897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RLG0"/>
    <dbReference type="EnsemblFungi" id="CEF88299">
        <property type="protein sequence ID" value="CEF88299"/>
        <property type="gene ID" value="FGRRES_04757"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04757"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16245"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="InParanoid" id="I1RLG0"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF88299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="306" mass="33529" checksum="0236CE42EE5DB078" modified="2012-06-13" version="1">MSFNPNNDIPDLSGKVIIVTGASSGLGKESALQLAKHNPATIFVTARTEKRGNAAIKEIQDAVPNFKGQIKFLELDLSSFASIQKGATAFLNQSDRLDILMNNAGLMATPAGLTTDGYEVQFGSNYMGPALFTKLLLPTIVRTAQQQGDARVINLSSELFKQAPKEGVLLSRVKTPLEDISSLARYGQSKLADYYHTRSLSKYYPSVKFVAIHPGVVNTGLFDDLRKRRPWLGGLIGVMGSIFLTDVHAGAKAQLWASTAKSESVRSGGFYNQKLKEYKDAVLDDEKAVEELWDWTEKEFASKGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1RLW1</accession>
    <accession>A0A098DZ10</accession>
    <name>I1RLW1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG04931.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T16665</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323402.1">
        <property type="nucleotide sequence ID" value="XM_011325100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RLW1"/>
    <dbReference type="EnsemblFungi" id="CEF86078">
        <property type="protein sequence ID" value="CEF86078"/>
        <property type="gene ID" value="FGRRES_04931"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04931"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16665"/>
    <dbReference type="eggNOG" id="ENOG502TERF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039322_0_0_1"/>
    <dbReference type="InParanoid" id="I1RLW1"/>
    <dbReference type="OrthoDB" id="5100145at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF86078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="509" mass="57458" checksum="0C731CFB3E28A747" modified="2012-06-13" version="1">MTSVSTHPFVDQLPVNGATCASRAEETLAQLDGLFAGFVFLHEIEPATTCTNSLRNGRSRQPQVGRAPWTNTTDGQPCRARDMAWSSIRAIRNEMETLWSQFVNVAGNLENVAVNRILADYQDAKGLQQTGAVALRNIFSGPVPNDLRKVFAFCCLSYVASHLLCARNMLAQGDILAGLRQWLYALDREDEREAFKLLVQHLWPEAQHHLHSMDSVHPFQSGTIDPSLINIQPTVMSPINIQNSAYPQQDPEFSLDLLDISNLDLGSQSHHLQGYDPRPSCPFIRSWTPMQLPYDASRQSPYDADPPFSIPSNDPETSNHLQQTSVFRAVLQYVQENADFWYNIAGRGLVSRDFRECLAWSQERLSRKMEIQRSFIHPLLLEKAKRDLVSRGIITIIEAFVERGLLQKRQEIEFYIQLAGTVRNNKPQNSSLANCFQCLFDDQVSFREFCDWIYGFRQTSPPLSVPMMQTSTSEFVNPSHVLCKKSADKLLESPTHVACVGTEVLDPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RM54</accession>
    <name>I1RM54_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG05035.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T16933</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by PDX2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323518.1">
        <property type="nucleotide sequence ID" value="XM_011325216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RM54"/>
    <dbReference type="FunCoup" id="I1RM54">
        <property type="interactions" value="270"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RM54"/>
    <dbReference type="EnsemblFungi" id="CEF87199">
        <property type="protein sequence ID" value="CEF87199"/>
        <property type="gene ID" value="FGRRES_05035"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05035"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16933"/>
    <dbReference type="eggNOG" id="KOG1606">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055352_1_0_1"/>
    <dbReference type="InParanoid" id="I1RM54"/>
    <dbReference type="OrthoDB" id="1660966at2759"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00343">
        <property type="entry name" value="pyridoxal 5'-phosphate synthase lyase subunit PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="11">
        <location>
            <begin position="20"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="9">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF87199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="311" mass="32766" checksum="7DEF189CF599EC55" modified="2012-06-13" version="1">MTNDNSNNTGASNGEAKSSFTVKAGLAQMLKGGVIMDVVNAEQARIAEEAGACAVMALERVPADIRKDGGVARMSDPAMIKEIQDAVTIPVMAKARIGHFVECQILEALGVDYIDESEVLTPADDESHVEKSPFSVPFVCGCRNLGEALRRIAEGAAMIRTKGEAGTGDVVEAVRHMKTVNRDIAQAKAALAEGGIVRIREMARKLEVDAELLRQTAELGRLPVVNFAAGGVATPADAALMMQLGCDGVFVGSGIFKSGDPAKRAKAIVRATTHFRDAKVLAETSTGLGEAMVGINCDSMKPEEKLAGRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I1RMA8</accession>
    <name>I1RMA8_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pro-apoptotic serine protease NMA111</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Pro-apoptotic serine protease nma111</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG05095.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T17089</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nuclear serine protease which mediates apoptosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323589.1">
        <property type="nucleotide sequence ID" value="XM_011325287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RMA8"/>
    <dbReference type="FunCoup" id="I1RMA8">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RMA8"/>
    <dbReference type="EnsemblFungi" id="CEF86943">
        <property type="protein sequence ID" value="CEF86943"/>
        <property type="gene ID" value="FGRRES_05095"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05095"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17089"/>
    <dbReference type="eggNOG" id="KOG1421">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003212_0_0_1"/>
    <dbReference type="InParanoid" id="I1RMA8"/>
    <dbReference type="OrthoDB" id="4217619at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120174">
        <property type="term" value="P:stress-induced homeostatically regulated protein degradation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06786">
        <property type="entry name" value="cpPDZ1_ScNma111-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06719">
        <property type="entry name" value="PDZ2-4_Nma111p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025926">
        <property type="entry name" value="PDZ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46366">
        <property type="entry name" value="PRO-APOPTOTIC SERINE PROTEASE NMA111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46366:SF8">
        <property type="entry name" value="PRO-APOPTOTIC SERINE PROTEASE NMA111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12812">
        <property type="entry name" value="PDZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ-like" evidence="8">
        <location>
            <begin position="390"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ-like" evidence="8">
        <location>
            <begin position="864"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF86943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1012" mass="112003" checksum="49789426ADA19F07" modified="2012-06-13" version="1">MNGAASSPRVKRKAPGSPDLPPPAKRAINGKHSPNDNTPDIVEFDDQSETSGDLHPHAMYIGTPGSLGEWQDTIQKVVRNVVAIRFCQTCSFDTDAALTSEATGYVVDSERGYILTNRHVVGAGPFWGHCVFDNHEEVDCYPVYRDPVHDFGILRYDPKAIKYMHIDGLELRPDLAKVGTEIRVVGNDAGEKLSILSGIISRLDRNAPEYGEGYSDFNTCYYQANAAASGGSSGSPVVNKDGCAVALQAGGRSDGASTDYFLPLDRPLRALQCIQNGKPVTRGDIQCQFLLKPFDECRRLGLSPEWEAAMRKQFPEETNMLVAEIVLPQGPSDKKIEEGDVLIKVNGELITQFIRLDDILDSNVGNTIKLHLQRGGEDVEVELEVGDLHKITPDRFVSVAGASFHDLSYQQARLYAVAVQGVYVCESAGSFRFDNTDNGWIVQTVDHKKVPDLDTFIQVMKAIPDRARVVVTYKHLRDLHTLNTTVAYIDRHWASKMKLAVRNDESGVWDFTDLGDPLPPVPPTRRSASFIELEHMPHPGIANLIHSFVHINCTMPLKLDGFPKNRRWGMGLVIDAEKGLVLISRAIVPYDLCDITVTIADSIIVEGKVVFLHPLQNYAMIQYDPSLVDAPVKSARLSNEVLTQGAKTYFLGYNRIGRVVHGSTSVTEITAVAIPANSGAPRYRAVNVDAITIDSNLGSTCNSGVLVAPDGTVQALWLSYLGERNPHSSRDEEYYLGLGTKTLLPVVESIQKGVNPKLRILSVEFRSIQMSQASVMGVSDEWIKKVTQANRSHHQLFMVSKRTFERVNQPVSLLEGDIVLTLNGKICTTISDFDLMYSHELLDVVIVRECAELHLQIPTVSADDIETDHAVSFCGAILHRPHQAVRQQISKLHSEVYVSSRIRGSPAYQYGVAPTNFITHVNGTPTPDIPSFIAATREIPDHTYFRLKAVTFDNVPWVITMKKNDHYFPTMEWIKDDKEACGWRRVTYEGSDAFKGEAIDGVAPVAEDAEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>I1RN19</accession>
    <name>I1RN19_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG05379.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T17765</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
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        <property type="protein sequence ID" value="CEF86993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_011325601.1"/>
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    <dbReference type="FunCoup" id="I1RN19">
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    <dbReference type="STRING" id="229533.I1RN19"/>
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        <property type="protein sequence ID" value="CEF86993"/>
        <property type="gene ID" value="FGRRES_05379"/>
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    <dbReference type="KEGG" id="fgr:FGSG_05379"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17765"/>
    <dbReference type="eggNOG" id="KOG0769">
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        <property type="entry name" value="MCP"/>
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        <property type="entry name" value="MCP_dom_sf"/>
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        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF1">
        <property type="entry name" value="MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
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    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
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            <end position="32"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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            <dbReference type="ARBA" id="ARBA00022792"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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    </evidence>
    <sequence length="340" mass="36408" checksum="AB2928B784B826C5" modified="2012-06-13" version="1">MAAQSKPEISPWGRAVAGATGAVLANALVYPLDIVKTRLQVQIKPDPSKEPSPTDEPHYTSTWDAISRIVADDGIKGLYAGMNGSLIGVASTNFAYFYWYTIVRTLYLKSRKTDANPSTVVELGLGAIAGAIAQVFTIPVAVVTTRQQTASKCDRKGLMATAREVIDGPDGVSGLWRGLKASLVLVVNPAITYGAYERLKEVMYPGKTSLRPGEAFLLGAMSKALATIATQPLIVAKVGLQSKPPPARNGKPFTSFVEVMKFIIEHEGMLGLFKGIGPQILKGLLVQGILMTAKERVELMFILLIRYIKSIQLRKISRAAEKTAVAAAAHSVAAQPVTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I1RNP5</accession>
    <accession>A0A098E2Z9</accession>
    <name>I1RNP5_GIBZE</name>
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        <submittedName>
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        <name evidence="2" type="primary">FG05629.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T18369</name>
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    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324192.1">
        <property type="nucleotide sequence ID" value="XM_011325890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RNP5"/>
    <dbReference type="EnsemblFungi" id="CEF88481">
        <property type="protein sequence ID" value="CEF88481"/>
        <property type="gene ID" value="FGRRES_05629"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05629"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18369"/>
    <dbReference type="eggNOG" id="ENOG502S9HK">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_050866_1_1_1"/>
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        <property type="component" value="Chromosome 3"/>
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    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40518">
        <property type="entry name" value="ACETOACETATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40518:SF1">
        <property type="entry name" value="ACETOACETATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF88481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="289" mass="32481" checksum="0615B692C0756266" modified="2012-06-13" version="1">MSDLNIPSVPPPWTLKGDIYAFLFWTSRAQAGNLPDMAYSPLEADSSFAKDQKALGGLSMMQIIRYTDSPVGPYDELILAPGVFGYEKDDENGRKVRGKDIKITRIYVSQKHTCYNGRKNWNVPKHLAEFIWSNNTDGSTTVKVYPNDTAPTDPNSGFTESAVPASTPFFQATFKPVGYTPSFPFRTSWLNYLGFDPTLVFPPLPEGAGSQGELPGTDRWCSIVPQQSSSKCKLGWFDVEQHRNEDRNSAGPHENFWPGWRKWQIGFKMADAVIGFDHPEIWEASRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RR32</accession>
    <accession>A0A098DRT9</accession>
    <name>I1RR32_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG06539.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T22535</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326150.1">
        <property type="nucleotide sequence ID" value="XM_011327848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RR32"/>
    <dbReference type="STRING" id="229533.I1RR32"/>
    <dbReference type="EnsemblFungi" id="CEF84087">
        <property type="protein sequence ID" value="CEF84087"/>
        <property type="gene ID" value="FGRRES_06539"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06539"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22535"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024886_0_0_1"/>
    <dbReference type="InParanoid" id="I1RR32"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124425" evidence="6">
        <location>
            <begin position="28"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF84087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="515" mass="58414" checksum="3EB91AFEB86CBF62" modified="2012-06-13" version="1">MPFNSGLVNPILHPLIFLFQIFQWITAKLLSPRPPNENARLGHNRPKIAVIGAGITGVTSAAHCIGHGFDVVIFEAGSKDNVGGIWSRVNETSGLQIHSLMYRFHPSVQWNRGYPDRQQILSQVRHLWERYGLKERTRFNTKIDRVYQDEQGRWIVNNPSLGRFGGVIAAVGTCGAPKMPKIHGMDNFKGPIYHSSDLTGKDVKGKKMAIIGGGASAVESLEFAFAEEAAQVSILSRSDKWIIPRNMFVDALLSFNIFGHETVLSFIPEFFLRKFFYRDLENISPAKNHGLFMETPMVNSDIMDKLREGKVEWVRCDIDEFVYQGVRVNRRAKGVPQGGPGHEEVIDADIIVMATGYKRPSLSFLPDDCFREPYPPPNWYLQTFPPSHPSVSAINCTYVNAIGTVGNWHIGIYTRILLMFLMDPLSRPSPFWMQRWIDLTKTLKLTSPTGAFDFFTYLELLWWFFFCVVVNPFRWKWAIFVFLGVGFGLLEAVVSQEERITNGNGYHARDEGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RS34</accession>
    <name>I1RS34_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG06941.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T23555</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326611.1">
        <property type="nucleotide sequence ID" value="XM_011328309.1"/>
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    <dbReference type="AlphaFoldDB" id="I1RS34"/>
    <dbReference type="FunCoup" id="I1RS34">
        <property type="interactions" value="521"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RS34"/>
    <dbReference type="EnsemblFungi" id="CEF85151">
        <property type="protein sequence ID" value="CEF85151"/>
        <property type="gene ID" value="FGRRES_06941"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06941"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23555"/>
    <dbReference type="eggNOG" id="KOG3368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053380_4_0_1"/>
    <dbReference type="InParanoid" id="I1RS34"/>
    <dbReference type="OrthoDB" id="3364529at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000013">
        <property type="entry name" value="TRAPP complex subunit, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF85151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="145" mass="16540" checksum="40842FAD480D7FBB" modified="2012-06-13" version="1">MVVYSFHIFDRHTECVYSKSWLPSSAGSEVAAPTTSSDDAKLLFGTVFSLRNMVRKLGGDDDAFISYRTAQYKLHFYETPANLRFVILTDTATLSMRNVLHQIYINLWVEYVVKNPLAPVEHKKGEGVKNELFELGLDQFIRGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1RSB2</accession>
    <name>I1RSB2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG07026.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T23771</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF82895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326714.1">
        <property type="nucleotide sequence ID" value="XM_011328412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RSB2"/>
    <dbReference type="EnsemblFungi" id="CEF82895">
        <property type="protein sequence ID" value="CEF82895"/>
        <property type="gene ID" value="FGRRES_07026"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07026"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23771"/>
    <dbReference type="eggNOG" id="ENOG502RKWS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_193160_0_0_1"/>
    <dbReference type="InParanoid" id="I1RSB2"/>
    <dbReference type="OrthoDB" id="4835952at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124475" evidence="1">
        <location>
            <begin position="18"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF82895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF82895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="67" mass="7488" checksum="67788E7B9EC6EAD8" modified="2012-06-13" version="1">MKFQLFTIIALVSAASAGLIKRVDVEVPAMTDAQGNVVVFNAAEVPTRKRRAIAEQQKQQQQQKKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>I1RSQ4</accession>
    <name>I1RSQ4_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG07182.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T24167</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326904.1">
        <property type="nucleotide sequence ID" value="XM_011328602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RSQ4"/>
    <dbReference type="FunCoup" id="I1RSQ4">
        <property type="interactions" value="887"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RSQ4"/>
    <dbReference type="EnsemblFungi" id="CEF84522">
        <property type="protein sequence ID" value="CEF84522"/>
        <property type="gene ID" value="FGRRES_07182"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07182"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24167"/>
    <dbReference type="eggNOG" id="KOG0460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_0_0_1"/>
    <dbReference type="InParanoid" id="I1RSQ4"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03707">
        <property type="entry name" value="EFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="53"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF84522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="445" mass="49196" checksum="97AFA9AF9312A66F" modified="2012-06-13" version="1">MSTAFRSVAPFLRTARQGLRANPVNPLQSAFTKKNASGVLNLYRTYAVFERSKPHVNIGTIGHVDHGKTTLSAAITKRQADKGLANFLEYGAIDKAPEERKRGITISTAHIEYATENRHYSHVDCPGHADYIKNMITGAANMDGAIIVVAASDGQMPQTREHLLLARQVGVQRIVVFVNKVDAIDDPEMLELVEMEMRELLNTYGFEGDDTPVIMGSALMSLQNQRPEIGTQKVDELLAAVDEWIPTPERDLDKPFLMSVEDVFSIAGRGTVVSGRVERGILKRDQEIELVGKGQEVIKTKVTDIETFKKSCEQSQAGDNSGLLIRGVRREDVRRGMVVCAPGTVKSHTQFLASLYVLTKEEGGRHTGFQEHYRPQLYLRTADESIDLTFPEGTEDATSKMIMPGDNTEMVVTMGHPNAIEVGQRFNIREGGRTVATGLCTRIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1RT15</accession>
    <accession>A0A098DS80</accession>
    <name>I1RT15_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG07305.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T24475</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327051.1">
        <property type="nucleotide sequence ID" value="XM_011328749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RT15"/>
    <dbReference type="EnsemblFungi" id="CEF84222">
        <property type="protein sequence ID" value="CEF84222"/>
        <property type="gene ID" value="FGRRES_07305"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07305"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24475"/>
    <dbReference type="eggNOG" id="ENOG502QQEZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020826_1_2_1"/>
    <dbReference type="InParanoid" id="I1RT15"/>
    <dbReference type="OrthoDB" id="442243at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF1">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF84222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="420" mass="45503" checksum="49516570A7106C64" modified="2012-06-13" version="1">MKKTLLLCFIHGFKGGEDTFGVDYQFTKDLRDLVREALPKIKVESIVYPKYETRGDLGNCVSHFRDWLQDRVIDMEVAAGTPSPTIEPSVRTILIGHSMGGIVAAEMLIGLASEKPIYTEDGIQKSETPSFNSLMFPYIQGVLAFDTPYLGISPGVVAHGAEDQYQTASQAIGAISQLSGLGASFWGATQAASATTTPALPKTAGALPAPSASGGSQWQKWGKMAMYAGAAGAVAAGGAAAWMNRDQLGEGWSWASSHLEFVGCLARGEELRKRVSCLLQLREELDVGFANMYTRLGKAAPAKEINLVGTVLGKDRTFCNLPKKQPGGVWKEAINDKATDEAGAHMNMFTPKENPGYNKLAQDATQFIHDWLQNDWYQTSAEEPLLLKEAPKPADNPLHEENPWADEKPSPEDAGVRDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1RTK8</accession>
    <name>I1RTK8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG07517.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T25001</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327293.1">
        <property type="nucleotide sequence ID" value="XM_011328991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RTK8"/>
    <dbReference type="EnsemblFungi" id="CEF84143">
        <property type="protein sequence ID" value="CEF84143"/>
        <property type="gene ID" value="FGRRES_07517"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07517"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25001"/>
    <dbReference type="eggNOG" id="ENOG502RKUS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_637840_0_0_1"/>
    <dbReference type="InParanoid" id="I1RTK8"/>
    <dbReference type="OrthoDB" id="3555317at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF84143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="458" mass="50497" checksum="1824E182332E43D5" modified="2012-06-13" version="1">MTAQSPTKRRGRLSSSTQENDDAALKARRERNREAQNIFRRRRQAAEAAQAQRVRRLEQVVEEMSSVFMSFVDEMLTTEAIVNGQPSLVGSLRRSMERILELAHEVVGPEEDLVVLPRSSSPTDDNRPTDKSQSPDSERSETTSDSGSSLAVTLRRVHPVQPPQTSALTSALSTSNSTTSATSISPPTPQFTTLHNFQQPSLGKPVSIPSFNLAPQIFGNGWLGTTPTAPSEVVPTGPQYNSPFSFRLANTALTIACQLLVNSPPEHAMTPMQARLFCNTLKGRAKEEMLTRLRWLIGPGKHEMYRVIDLPYGRYGHHVYARGELNPTTMEDIEWPWPTRPAGSRIDHFTRFFSIVGVEKQLLALGARMIDSETLELNLNNSPMPDVGSAIPKQPESWSFVNCFSFPTQPKNSPVTVRLSVPALVLSLATRSCCLMRGPGIPRSEIGSAIEEAIIKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>I1RUG4</accession>
    <name>I1RUG4_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase CHL1</fullName>
            <ecNumber evidence="18">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-dependent DNA helicase chl1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Chromosome loss protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19 20">DNA 5'-3' helicase CHL1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">FG07857.1</name>
        <name evidence="25" type="ORF">FGRAMPH1_01T25829</name>
    </gene>
    <organism evidence="25 27">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="26">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="26 27" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="27">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="26">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="25 27" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="25">PH-1</strain>
        </source>
    </reference>
    <reference evidence="26" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="18"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327685.1">
        <property type="nucleotide sequence ID" value="XM_011329383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RUG4"/>
    <dbReference type="FunCoup" id="I1RUG4">
        <property type="interactions" value="1002"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RUG4"/>
    <dbReference type="EnsemblFungi" id="CEF85477">
        <property type="protein sequence ID" value="CEF85477"/>
        <property type="gene ID" value="FGRRES_07857"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07857"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25829"/>
    <dbReference type="eggNOG" id="KOG1133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006515_2_0_1"/>
    <dbReference type="InParanoid" id="I1RUG4"/>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045005">
        <property type="term" value="P:DNA-templated DNA replication maintenance of fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031571">
        <property type="term" value="P:mitotic G1 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001372">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002774">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="24">
        <location>
            <begin position="14"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CEF85477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="863" mass="96061" checksum="FFDAADAA40F473C9" modified="2012-06-13" version="1">MAENDMENITSEMEKLDFHHPYTPYDVQEQFMKAVYDVLESGNGQVGILESPTGTGKSLSLICASLTWLRNHKSNQFETSIQESAEAYKDEPSWLVEQLLRRKREELVSRWEEREKRLETLRLKEKVQEERARKRRRVEDSLLSGRSRVVEDEDAEWLLDDPDDQHDTPQDSLSGLSKETREVLAGIGLGGARKPEEDDDLVEEPIKIYYTSRTHSQLSQFITELRRPSFPPSLPTSLSKQEETKTEAVKLLPLSSRQRLCINPSVSRLGSVQAINDRCSELQQPKSGQKCPFVPKEDLLSQTHQFRDSALATLPDIEDLHQLGKSLAVCPYYASRTALPGAEIITLPYPLLLQKSARDALGVKLEGSIVIVDEAHNIMDAVANVHAAEIKLSDLRRGRGMLGVYVKRFGKKLKGVNRVNVGRVARVIDGLSEWMDGALKFKQEHGIVDPNDLTRSKGIDQINMFELIQYIQDSKLAFKIESYISHVESEDAGTKTPRSSTPVLHSLVSFLIALTNLSSEGRIFYQKIKGTPDIQLSYLLLSPTHAFSSIASSARAVILAGGTMSPFDDYKDHLFPSLEPEKVTTLSCGHVIPPENLCVWTLASSRPGAPPFEFSFQKRGDPEMITQLGLAILNLCSLVPDGVVIFFPSYGYLDEVVAVWQKSQGASTQSVWDRLGTRKALFKETRGASSEEVLQEYSDAIQGEKSNGKGALLLSVVGGKMSEGINFSDRLGRCVLVIGLPYPNIASPDWKAKIEYIETTTRNNLVAQGTTHEEAVSKAKQTARDFYENACMRAVNQSIGRAIRHRGDYAAIVLVDRRYGTDRIRGKLPGWIRGGLVGDSHEKGLGGLMGAVGGFFRGKKSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RVU6</accession>
    <name>I1RVU6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG08391.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T09839</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320386.1">
        <property type="nucleotide sequence ID" value="XM_011322084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RVU6"/>
    <dbReference type="EnsemblFungi" id="CEF76722">
        <property type="protein sequence ID" value="CEF76722"/>
        <property type="gene ID" value="FGRRES_08391"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08391"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09839"/>
    <dbReference type="eggNOG" id="ENOG502S9MA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051542_0_0_1"/>
    <dbReference type="InParanoid" id="I1RVU6"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="94"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF76722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="276" mass="31467" checksum="55D388E71C58C2DE" modified="2012-06-13" version="1">MLLSMDVMKVRDWTYLEDPPQDIGPARHLLEFYSKIPFNDLDGHIRRVREKAWCVSQYPCVGRWKFLYIPDPKDPRYQQALFRLNVAGSRDVLLDLGCGVGQVIRQFRADGVDGAQLIGTDLQSKFIDIGYDLFQDRHQLGASFVAGDMLDPEDKQMASLRGKITMVHAGSFFHLFNWIQQLYIGKRVVEFLKPGTRNAIIYGRQVGTNHPGPTSTSTRSAYLHDQASFQRLWDEVGDLTKTRWQVQVEPTGEPVSKVPGFNSHAFPVNFTVYQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>I1RWB5</accession>
    <name>I1RWB5_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG08578.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T10303</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320172.1">
        <property type="nucleotide sequence ID" value="XM_011321870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RWB5"/>
    <dbReference type="STRING" id="229533.I1RWB5"/>
    <dbReference type="EnsemblFungi" id="CEF76955">
        <property type="protein sequence ID" value="CEF76955"/>
        <property type="gene ID" value="FGRRES_08578"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08578"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10303"/>
    <dbReference type="eggNOG" id="KOG1613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038194_5_0_1"/>
    <dbReference type="InParanoid" id="I1RWB5"/>
    <dbReference type="OrthoDB" id="45882at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
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        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:rRNA catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="44"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="12">
        <location>
            <begin position="244"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF76955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="336" mass="36919" checksum="257504E5C6D599B3" modified="2012-06-13" version="1">MASTTGLTRSTFAKLSPHPYLLANLKPSSNDVRPARSNGRASDEVRTPTVNASSLSHANGSAVVRVGDTTVICGVRAETILTQNIPSYRAANTETELKEYDLLVPNIELATGCAPQFLPGGPPSTLAQTLSTRIYSLLHSSKIINPEDLRIWHTAPSEDFEAAEDRMEEDDAETVNENRSVVAYWVLYIDIFFISFDGNPFDAAWAATMAALRDTKLPGARFDLDREMIVCSRKESRPLSITSIPIACTAVVFTGKETDRPTDGEFWMLVDPDRLEESLCDESVTIVVDCKNGKVNILSISKHGGIALTPQFLTSEQFLGWATKRWEQFNAAITQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1RWQ4</accession>
    <accession>A0A098DDW2</accession>
    <name>I1RWQ4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG08734.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T10691</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319995.1">
        <property type="nucleotide sequence ID" value="XM_011321693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RWQ4"/>
    <dbReference type="EnsemblFungi" id="CEF77148">
        <property type="protein sequence ID" value="CEF77148"/>
        <property type="gene ID" value="FGRRES_08734"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08734"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10691"/>
    <dbReference type="HOGENOM" id="CLU_839510_0_0_1"/>
    <dbReference type="InParanoid" id="I1RWQ4"/>
    <dbReference type="OrthoDB" id="10595478at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="341" mass="37976" checksum="484BC399B63E3593" modified="2012-06-13" version="1">MSLTGNGPTQSQVPATTLWPPWAVDRTRFLQARPLSHLVPTYQGTKLKASSEQPLFRSSQPHKAIHSFSLHSEPVNNTLLVTSFFLTHTIYCEIETSVDLLLMTANMSANRQVSGGYKHEPALHPTLVTASSEGWTLSEDSGNTRLLTYPCNIPVASLTSSGVPRWTRQGIFCFTMTGARPPAGNRGGVARLASFDRGIHVEPPKIGEEKRRDVAAHSNRSLDINHIDAQRHCMHQPHRFTGTTNGDKTTTKAINRLRRFNDLIQPLKSIRFWVFGYNSNATEVKLDSHPPNGCEAGDERASVRLPMNAHYTTQPKSRQRAAATRTSSRWMMPEKDAERDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1RWU9</accession>
    <name>I1RWU9_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG08784.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T10811</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319939.1">
        <property type="nucleotide sequence ID" value="XM_011321637.1"/>
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    <dbReference type="FunCoup" id="I1RWU9">
        <property type="interactions" value="515"/>
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    <dbReference type="STRING" id="229533.I1RWU9"/>
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        <property type="protein sequence ID" value="CEF77208"/>
        <property type="gene ID" value="FGRRES_08784"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08784"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10811"/>
    <dbReference type="eggNOG" id="KOG3094">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="I1RWU9"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="C:Golgi membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF77208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="325" mass="36165" checksum="20AF778C3A61C848" modified="2012-06-13" version="1">MQRAAYAQSPPLHHPVPQHVSTVPQLRSPPPPPGSAQSQQGYAANAGGNPYQQQGGNSGNVFGAYGNFMNDPTAQVAAQFGQTAFRHGQEYVEQNLGRYVNVSALKHYFNVSNSYVVNKLFLVLFPWRHKPWSRKQAVGQNGQDGWYLPPRDDINSPDMYIPVMALVTYILLSTLIAGLNHQFQPELLGKTATISLIVVIVEIFFLKLGCYLLSISSQSQLLDLIAYSGYKFVGIIVTVVVAEILNGGKGTGGWVGWLIFFYTYLANSLFLMRSLKYVLLPETAAGVSGGPMQTDSRAKRSQRTKFLFMYSYFVQLFFMWILTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RY94</accession>
    <name>I1RY94_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG09335.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T27343</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF82858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328418.1">
        <property type="nucleotide sequence ID" value="XM_011330116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RY94"/>
    <dbReference type="EnsemblFungi" id="CEF82858">
        <property type="protein sequence ID" value="CEF82858"/>
        <property type="gene ID" value="FGRRES_09335"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09335"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27343"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_0_4_1"/>
    <dbReference type="InParanoid" id="I1RY94"/>
    <dbReference type="OrthoDB" id="4050368at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS multidrug transporter, putative"/>
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        <property type="entry name" value="MFS"/>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="170"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="13"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF82858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF82858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="608" mass="66146" checksum="2675986318EB8657" modified="2012-06-13" version="1">MSNYIPSFSAPNSRPGSPLPLGSPSASRPTSFFANSRANSFVGTRRNSAVPPTSRKNSVAAPSRKNSTVAPSRPDSEDKSSSDPESTDVEVLKNEKGEPLAGRIVGGKYVDPANESIDPEFGAIKTVDIDMPLTLTEVVKENGKEYIVLGFASGDKENPFNWNPWYKRSISTILNLMTLFIGLATTAYSSGIASMCEDLNAPNIKGQLGLFTFNISCAIAPMILAPFCELVGRKVVYASSFLCFSLLFIGLALAQDINTIIGLRLLLGLFGCVGTILVGGTFDDMYEPHHRSRPMAMFSWVAIFGTVGAPIYAGFINQSLGWRWIEGIQGIANVPLLLVIFFYFPETRGGVALHKRAKALRQATGDERYVSAGDILTPSLQAMLKASSVKAIHMLVTEPVVFAFGLWIAFCWAVVFLFLSVIPITFQEHHGWGEGVAGLPYISLCIGTTLGWLAHHFQMRKFDRLVADPDIKVTPEARLYGAMYGAMFLPIGLFIYSFTQYSHVSWVGPAIGLAPIAFGIYFVFESTYSYTADCYGESSSSAIAGQGLMRNTLGAVTPLFANAFFHNVGSQYAGLILAIFGTILSLIPFVMFKYGHKLRARSKLAIEM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZD0</accession>
    <name>ERG8_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphomevalonate kinase ERG8</fullName>
            <ecNumber evidence="6">2.7.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ergosterol biosynthesis protein 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ERG8</name>
        <name type="ORF">FG09764</name>
        <name type="ORF">FGRAMPH1_01T26385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="1228" last="1228">
            <title>A phosphorylated transcription factor regulates sterol biosynthesis in Fusarium graminearum.</title>
            <authorList>
                <person name="Liu Z."/>
                <person name="Jian Y."/>
                <person name="Chen Y."/>
                <person name="Kistler H.C."/>
                <person name="He P."/>
                <person name="Ma Z."/>
                <person name="Yin Y."/>
            </authorList>
            <dbReference type="PubMed" id="30874562"/>
            <dbReference type="DOI" id="10.1038/s41467-019-09145-6"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 6">Phosphomevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (By similarity). ERG8 converts 5-phosphomevalonate to 5-diphosphomevalonate (By similarity). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 (FG05912) first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8 (FG09764). The diphosphomevalonate decarboxylase ERG19 (FG10424) then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 (FG09722) then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 (FG06784) catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP</text>
            <dbReference type="Rhea" id="RHEA:16341"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:16342"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="induction">
        <text evidence="3">Expression is regulated by the Zn(2)-C6 fungal-type transcription factor FgSR which binds directly to the promoter.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="6"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327956.1">
        <property type="nucleotide sequence ID" value="XM_011329654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZD0"/>
    <dbReference type="SMR" id="I1RZD0"/>
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    </dbReference>
    <dbReference type="STRING" id="229533.I1RZD0"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T26385">
        <property type="protein sequence ID" value="FGRAMPH1_01T26385-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G26385"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09764"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26385"/>
    <dbReference type="eggNOG" id="KOG4519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022059_1_0_1"/>
    <dbReference type="InParanoid" id="I1RZD0"/>
    <dbReference type="OrthoDB" id="10262935at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="Phosphomevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016005">
        <property type="entry name" value="Erg8"/>
    </dbReference>
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        <property type="entry name" value="GHMP_kinase_C_sf"/>
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    <dbReference type="InterPro" id="IPR006204">
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    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
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        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017288">
        <property type="entry name" value="PMK_GHMP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0752">Steroid biosynthesis</keyword>
    <keyword id="KW-0753">Steroid metabolism</keyword>
    <keyword id="KW-0756">Sterol biosynthesis</keyword>
    <keyword id="KW-1207">Sterol metabolism</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000454674" description="Phosphomevalonate kinase ERG8">
        <location>
            <begin position="1"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P24521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="30874562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="30874562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="30874562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF85588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="443" mass="47639" checksum="1545F3E8A9033C5E" modified="2012-06-13" version="1">MSLKHPTIAVSAPGKVFLAGGYLVLDQEYTAFVFGLNARINIIAGDIHTTAGVQLTEIVVDSPQFLDAQWRYGYHLAGEGGGIKVTQLQVGAQINPNPFVETTLSYALTYIDRVAGHRPSHSLASARLIILADNDYYSHSESDTTRSGRFAKFPVTLSNANKTGLGSSAALVTSLTASLLVHYLPEDLFSIDSDKGKRTLHNLAQAAHCAAQGKVGSGFDVATAVYGSCRYRRFSPATLNKIPEPGVAGFADALVKLVDGESEWDVEVLKDAVTMPKGVVLRMCDVDCGSKTVGMVKKVLAWKSSNPEDSKTLWDELQSRNEQLIATLNAGDVAQLPEKINAVREKIREMGSASDVPIEPESQTELLDALSTVEGVHGGVVPGAGGYDALALLMKDDEETKQRVEVFLEKWAAEKGTKVKLLAVKGEMEGVRSESLDVYAGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZS8</accession>
    <name>I1RZS8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG09932.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T06865</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318839.1">
        <property type="nucleotide sequence ID" value="XM_011320537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZS8"/>
    <dbReference type="STRING" id="229533.I1RZS8"/>
    <dbReference type="EnsemblFungi" id="CEF75236">
        <property type="protein sequence ID" value="CEF75236"/>
        <property type="gene ID" value="FGRRES_09932"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09932"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06865"/>
    <dbReference type="eggNOG" id="KOG0715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050546_0_0_1"/>
    <dbReference type="InParanoid" id="I1RZS8"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053025">
        <property type="entry name" value="Mito_ATP_Synthase-Asso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44873">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44873:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="53"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF75236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="306" mass="33939" checksum="32C3BF30139FF13C" modified="2012-06-13" version="1">MPLRPSLLCSLRSAPIPPACSARLLRCSAPAIGVHGLQSQQRRGRHDEVAKKNHYERLNLRHDATPAEIKKSFYSLSKTHHPDANRSDPNASSTFSLISESYTVLSDKSRRSAYDRDVLRLHHHPPQTATQRGSYHSHQAGGRAPSGLSRRRGTFRGPPPSFYRSGGWGDQADKRRKAHEESTGGGASSQEQGASHSRNQSPWGDPFKPEASAHGGMGPGGDPFGHQNDVPHFDKAGHTRTHQREDERRKSRWQKRAMGDDDVEFEPQTSITGHFIIISGILATTILAPLIYIQFMSIGQQKKEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1S0X1</accession>
    <name>I1S0X1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG10362.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T07919</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319331.1">
        <property type="nucleotide sequence ID" value="XM_011321029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S0X1"/>
    <dbReference type="FunCoup" id="I1S0X1">
        <property type="interactions" value="606"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1S0X1"/>
    <dbReference type="EnsemblFungi" id="CEF75763">
        <property type="protein sequence ID" value="CEF75763"/>
        <property type="gene ID" value="FGRRES_10362"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10362"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07919"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_1"/>
    <dbReference type="InParanoid" id="I1S0X1"/>
    <dbReference type="OrthoDB" id="3633556at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05926">
        <property type="entry name" value="FACL_fum10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045310">
        <property type="entry name" value="Pcs60-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="26"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="421"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF75763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="514" mass="56257" checksum="AFC63A8758CF00A2" modified="2012-06-13" version="1">MSTLQSAINKSNPLAEAIIIPSKPKALTISYANLESDVSAFQRKLADLGITKAAPVSIALINSYEFIVSFLAASWQRGIAAPLNPAYKQDEFEFYIDDVKSAIVLVPRGAYAAGAPSVKAAKKFNAAVAECYWDEAKGEVALDVKDYGLLKGKKERVLTAEPDDVALILHTSGTTSRPKVVPLTHRNLTRTMNNIKNTYELTPKDRTMLVMPLFHVHGLLCGLLAPLFTGGSMVVPTKFSASEFWTDFNTHKANWYTAVPTIHQILLKNPPPSPKPNIRFIRSCSSPLSPTVFQQLEETYNAPVLEAYAMTEAAHQMTSNPLPPAKRKAGTVGIGQGVEVKILTDQGEEVPQGTEGEICIIGENVTKGYLNNDKANAESYHKNGFFRTGDQGKKDEDGYIIITGRIKELINKGGEKISPIELDNVLTRHPQISEAVSFAIPDEVYGQDIGVAVVLKNGGKLTAQELKAWVEERSAKFKVPKKVYFTEVMPKTATGKIQRRIVAETMMTAPKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1S285</accession>
    <name>I1S285_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG10871.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T20677</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325516.1">
        <property type="nucleotide sequence ID" value="XM_011327214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S285"/>
    <dbReference type="STRING" id="229533.I1S285"/>
    <dbReference type="EnsemblFungi" id="CEF86566">
        <property type="protein sequence ID" value="CEF86566"/>
        <property type="gene ID" value="FGRRES_10871"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10871"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20677"/>
    <dbReference type="eggNOG" id="ENOG502RVJZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006328_0_0_1"/>
    <dbReference type="InParanoid" id="I1S285"/>
    <dbReference type="OrthoDB" id="5401106at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF86566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="976" mass="108354" checksum="9AAE76CA22980FA2" modified="2012-06-13" version="1">MSTDNKQLGSIVAFEGHVDTISTQLRLLPSSPQILILPNVQNYIPNEETDHRSDVRLYVKRIHEAAVARHEAARAFLQESTPTNRRLVFMSGGTSSARALCIKAIMDQETEGDANQAESLFHQLTKDGVLGLNNSLRDWRCPTMFDCLNSQGLGDELEDPITRAMRAAEALDRQTASLQPSTEVDLTLTLAPRPRSNSLPLYGYNDNFGDNAPFFVFGAQKNEEGGNVAEEAKGYSHPTQPSRFSRFSITHYDRSADRIYRGITHLQSPSFKTSFVASPSCVGESYNLMAGSVSPGLEAMTPRSDVLSILSTDNVVYGEASVLDMRSPSRSSTLSRVKSLDRIYPTTPKYRDLCVPAANLEPRQSDLDVEHESFETRRTSKAISINRRSHVEVPRTIIVKTNLPVIKMAPVPLEKKRKPARESYVDRGTDAKDMAEPKAFQPVLSLIEDLVVHFKEDVSDPLLDSVVRGFKTGHFSTFLQSPTSEPDDYNTFVPPTPESQNITSVRCIEDQYHEPPFHKKLDLGEYDPFAYNQPSWLKRKPLPNLPKVTVERPPTPVRTPPLLVSDMDNKIHDLQVNGQQTAIAVQNSLRSVLQDYFPPETRGYRQFQFPLLPELEGLWKPVFWDIAPNGSQESCHRIDQIFAIGAQRGVKRDYTSAVTGQLEKLGTKHSGMSRSGRLDFRYLLANAMQAYTTQPLANQTKDNPFNNPFLLATLIIPHLETYLALHTEVRYLLLEYPPEHLSAVLALQKLVGIDMMKVAQIIDTSSKNMPFTHLRGNSITGPEQGPVGRFGKTYPPKSCSGHDATVSKANFLLTSTASDAEIATFVATVSKILSGISCFYVPEELPKKHSPKKSKPSSVAGTFSAFPRIPSAPYSPPMSPTVGASVGTAFSDSSAMLSRTPSIAETVKTAKSTRSRPCRSKSNRKTLASDARSILTMYIDDSDWDSEDRRIMPLLEEKPNGHKANTHKALKFLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1S2D0</accession>
    <name>I1S2D0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG10919.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T20801</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325460.1">
        <property type="nucleotide sequence ID" value="XM_011327158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S2D0"/>
    <dbReference type="EnsemblFungi" id="CEF86513">
        <property type="protein sequence ID" value="CEF86513"/>
        <property type="gene ID" value="FGRRES_10919"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10919"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20801"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="InParanoid" id="I1S2D0"/>
    <dbReference type="OrthoDB" id="1932925at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF55">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="46"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF86513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="504" mass="55745" checksum="E8F1774871B45C77" modified="2012-06-13" version="1">MGQADEENARSATGNRDEAIAIVGEEQHAIDPIVAARAVRKIDIFLIPAMIIGYGLVYYDKAILGSAVLFGMTTDLNLTVVDASTTPPTLDTRRLSWATSLFYFGMLAGLYPMTFALQRFDIGRVLGGVVIVWSAICMLTAAVTSYQGLYVQRFFLGFVESIIPTGFMCIVSGYYTQSEQSLRQSWWFSSTGIFTIIGGSLNYGFAQITGGGLKRWQYIYLLAGSLTFLFGLFCFVMPNSPVSAWFLTSEEKFAAVERLRHGQTGVRCTKFKGSQLKEALLDVKIWLIALMMASAYTVNGAVSGFGPLIVSTFGWSTLHSILFQFPLGGLCFIVILLTGWLGSKFNNIRIFMLTFTCLPVIAGCAIIWKSDWSYRAAAPVVGYSITGFFGGTVSLIITIGMSNVAGHTKKSFMAATIFVAYCVGNIVGPQLVWSQTKKDHYPALWLGLIICYIICILASTTLYFVLRNENRRRDALGLEDESERAKLAFQDLTDKENPYFRYVY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-06-17" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1S2J6</accession>
    <accession>A0A098E518</accession>
    <name>FGM2_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidoglycan deacetylase-like protein FGM2</fullName>
            <ecNumber evidence="10">3.5.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">C64 cluster protein NRPS5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Fg3_54 cluster protein FGM2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Fusaoctaxin A biosynthesis cluster protein FGM2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FGM2</name>
        <name type="ORF">FG10992</name>
        <name type="ORF">FGRAMPH1_01T20963</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2012" name="Plant Cell" volume="24" first="5159" last="5176">
            <title>In planta stage-specific fungal gene profiling elucidates the molecular strategies of Fusarium graminearum growing inside wheat coleoptiles.</title>
            <authorList>
                <person name="Zhang X.W."/>
                <person name="Jia L.J."/>
                <person name="Zhang Y."/>
                <person name="Jiang G."/>
                <person name="Li X."/>
                <person name="Zhang D."/>
                <person name="Tang W.H."/>
            </authorList>
            <dbReference type="PubMed" id="23266949"/>
            <dbReference type="DOI" id="10.1105/tpc.112.105957"/>
        </citation>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="e110311" last="e110311">
            <title>The Fusarium graminearum genome reveals more secondary metabolite gene clusters and hints of horizontal gene transfer.</title>
            <authorList>
                <person name="Sieber C.M."/>
                <person name="Lee W."/>
                <person name="Wong P."/>
                <person name="Muensterkoetter M."/>
                <person name="Mewes H.W."/>
                <person name="Schmeitzl C."/>
                <person name="Varga E."/>
                <person name="Berthiller F."/>
                <person name="Adam G."/>
                <person name="Gueldener U."/>
            </authorList>
            <dbReference type="PubMed" id="25333987"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0110311"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="922" last="922">
            <title>A linear nonribosomal octapeptide from Fusarium graminearum facilitates cell-to-cell invasion of wheat.</title>
            <authorList>
                <person name="Jia L.J."/>
                <person name="Tang H.Y."/>
                <person name="Wang W.Q."/>
                <person name="Yuan T.L."/>
                <person name="Wei W.Q."/>
                <person name="Pang B."/>
                <person name="Gong X.M."/>
                <person name="Wang S.F."/>
                <person name="Li Y.J."/>
                <person name="Zhang D."/>
                <person name="Liu W."/>
                <person name="Tang W.H."/>
            </authorList>
            <dbReference type="PubMed" id="30804501"/>
            <dbReference type="DOI" id="10.1038/s41467-019-08726-9"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2019" name="Toxins" volume="11" first="277" last="277">
            <title>Fusaoctaxin A, an example of a two-step mechanism for non-ribosomal peptide assembly and maturation in fungi.</title>
            <authorList>
                <person name="Westphal K.R."/>
                <person name="Nielsen K.A.H."/>
                <person name="Wollenberg R.D."/>
                <person name="Moellehoej M.B."/>
                <person name="Bachleitner S."/>
                <person name="Studt L."/>
                <person name="Lysoee E."/>
                <person name="Giese H."/>
                <person name="Wimmer R."/>
                <person name="Soerensen J.L."/>
                <person name="Sondergaard T.E."/>
            </authorList>
            <dbReference type="PubMed" id="31100892"/>
            <dbReference type="DOI" id="10.3390/toxins11050277"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="5 6 10">Peptidoglycan deacetylase-like protein; part of the Fg3_54/C64 gene cluster that mediates the biosynthesis of the octapeptide fusaoctaxin A, a virulence factor that is required for cell-to-cell invasiveness of plant host (PubMed:30804501). The 2 nonribosomal peptide synthetases NRPS9 and NRPS5 form an assembly line which likely utilizes GABA as a starter unit (loaded on the unique module M1 of NRPS9) and sequentially incorporates seven extender units composed of the residues L-Ala, L-allo-Ile, L-Ser, L-Val, L-Ser, L-Leu and L-Leu, respectively (PubMed:30804501, PubMed:31100892). During the process, each of the residues that are tethered on modules M3-M7 of NRPS5 containing an E domain can undergo an epimerization reaction to produce a D-configuration before the transpeptidation reaction occurs (PubMed:30804501, PubMed:31100892). The elongation of the peptidyl chain might be terminated by module M8-mediated L-Leu incorporation, followed by R domain-catalyzed 4 electron reduction to release the resulting octapeptide from the assembly line as an alcohol (PubMed:30804501, PubMed:31100892). Fusaoctaxin A is cleaved by the cluster specific ABC transporter FGM5 to the pentapeptide fusapentaxin A and the tripeptide fusatrixin A (PubMed:31100892). The other enzymes from the cluster, FGM1, FGM2, FGM3 and FGM9 seem not to be involved in the biosynthesis of fusaoctaxin A and their functions have still to be determined.</text>
    </comment>
    <comment type="induction">
        <text evidence="3 4 6">Expression is positively regulated by the cluster-specific transcription factor FGM4 and is induced during infection of coleoptiles of wheat seedlings (PubMed:23266949, PubMed:25333987). The fusaoctaxin A gene cluster is silenced by H3K27 trimethylation by the histone methyltransferase KMT6 (PubMed:31100892).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3 5">Leads to reduced virulence and produces significantly smaller lesions and fewer spikelets with blight symptoms on susceptible wheat cultivars.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.-.-" evidence="10"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325378.1">
        <property type="nucleotide sequence ID" value="XM_011327076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S2J6"/>
    <dbReference type="SMR" id="I1S2J6"/>
    <dbReference type="STRING" id="229533.I1S2J6"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T20963">
        <property type="protein sequence ID" value="FGRAMPH1_01T20963-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G20963"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10992"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20963"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029940_1_0_1"/>
    <dbReference type="InParanoid" id="I1S2J6"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="PHI-base" id="PHI:9039"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF2">
        <property type="entry name" value="HYPOTHETICAL POLYSACCHARIDE DEACETYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000449949" description="Peptidoglycan deacetylase-like protein FGM2">
        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="65"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="B5ZA76"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="23266949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="25333987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="30804501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="31100892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="25333987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="30804501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <evidence type="ECO:0000305" key="10">
        <source>
            <dbReference type="PubMed" id="30804501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF88824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="338" mass="37828" checksum="1CE9D6EF5AC5A0D4" modified="2012-06-13" version="1">MQIDHSGDSSEASQAHDSKLHHSHLLGNIPLGLPEARRRVKILVSVDFDAVSGWMGTGQHSRNCLSDYSAGIFAGRVGVGRLLKILDRVGIAEKVTWFIPGHSMETFPLETKAIVDSGAEIALHGYCHEDCTQLDPQQQQDILDKCITLAESLTGKRPVGFRAPLYRIDHDTISLLERKGFLYDTSLSGHDAQLYYLDSGFPLDVVDYSKSASTWMKPSPQPRQLSVVEIPANWYMEDMTPMQFLPNVTNSHGFVSSEAIEKMWKDRFNWLWNWGPDGSGPGDFVFPLVLHPDTSGMAHVAGTIEGMLRWLKEWGPQVEFVTYEEAAREFLLDKEVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1S2Z3</accession>
    <accession>A0A098E5H6</accession>
    <name>I1S2Z3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG11153.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T21341</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325195.1">
        <property type="nucleotide sequence ID" value="XM_011326893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S2Z3"/>
    <dbReference type="EnsemblFungi" id="CEF88843">
        <property type="protein sequence ID" value="CEF88843"/>
        <property type="gene ID" value="FGRRES_11153"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11153"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21341"/>
    <dbReference type="HOGENOM" id="CLU_050245_0_0_1"/>
    <dbReference type="InParanoid" id="I1S2Z3"/>
    <dbReference type="OrthoDB" id="5416097at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF88843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="310" mass="34968" checksum="65F3D173BFA3B168" modified="2012-06-13" version="1">MSDFMLDENPYPNGIVDELQPSNPPVQPLPTFQIDPDYNLSGFGNQVQTSIFPLDIEAPINPFPLAAQGYPLAPAAQTNPIALESQTNPPAPLLNALHFATLLHMPMHILELIAKQPVNDPIRDLGTLYTAIQQIHEWSTQSSLPLGFKYPHISSPEESPERQKCVEYDNQRCIVTGHKIKTSCHVIPLSRRSLPGGAGHRLENIRSIMEYLVGFSHLSRDVESQELLGMLAAEVDIPKMYWNLITLTPGIANMWERGMFAFRWLHHTRIVADPWSHIGKVRITLEFVWMPFNTSRWRLAPFDLNAAQGL</sequence>
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    <accession>I1S3M5</accession>
    <accession>A0A098DZL7</accession>
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            <fullName evidence="2">Chromosome 3, complete genome</fullName>
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        <name evidence="3" type="primary">FG11415.1</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325811.1">
        <property type="nucleotide sequence ID" value="XM_011327509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S3M5"/>
    <dbReference type="EnsemblFungi" id="CEF86819">
        <property type="protein sequence ID" value="CEF86819"/>
        <property type="gene ID" value="FGRRES_11415"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11415"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22007"/>
    <dbReference type="HOGENOM" id="CLU_550999_0_0_1"/>
    <dbReference type="InParanoid" id="I1S3M5"/>
    <dbReference type="OrthoDB" id="5085838at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF86819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="495" mass="55846" checksum="A9DED331F0AAEF0D" modified="2012-06-13" version="1">MYRQGWNETPQRGSRNIPNPYGFQPNGTHWADEYDCLPLCQGGISCGKVHPGTGGHTAVQYLTPDASQMFGPESQPVNWDHNQRATAANQPASQIPFPAPSYPLGYITQPPARHLASSLSMKAERPLYPGFTYPYNHYLTDVAEDSAMPDWCMRPLTPDPEEQERWEQIVSDGAQDVGESSSGKEKDQVDPVTWEVSAKACQTELETINDKVDFVVRAMKKLLDQKQEGQTIFSHNNARLEVETEGESSGSQPRLKRESANEIDARKKLEALVEDPSQSADCTLDAPSIRTDLTPTVATTPNEETETSTLVLDPKQMEGMGDTHHTNEISSELDIKEEDAEKKAKIRDGPIWKYRIRHPAMVQPRNVDVDNRRIYAKLLAQSNRQTKPWDGDLSNLEAFLLGPFYECDDNTGIRDKIFNLFAEISGVSIELCYVKNEQRMKLFVLVPPFYAENENARSSFELMKNAEDVSKLLLQQRADCFDVEIWEANFRLDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1S3S7</accession>
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            <fullName evidence="4">Chromosome 3, complete genome</fullName>
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        <name evidence="5" type="primary">FG11473.1</name>
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    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325743.1">
        <property type="nucleotide sequence ID" value="XM_011327441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S3S7"/>
    <dbReference type="SMR" id="I1S3S7"/>
    <dbReference type="FunCoup" id="I1S3S7">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1S3S7"/>
    <dbReference type="EnsemblFungi" id="CEF88096">
        <property type="protein sequence ID" value="CEF88096"/>
        <property type="gene ID" value="FGRRES_11473"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11473"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22151"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_4_1"/>
    <dbReference type="InParanoid" id="I1S3S7"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF252">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08550)-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF88096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="341" mass="37343" checksum="CF64325A2BC0D0E4" modified="2012-06-13" version="1">MVARTSEFASASSRLPALTLSSGRLLITSQFTKPQLPPISLDLSGQTAIITGANNGIGLACAKLLLQHGLSHLIIAVRSEAKGHEAAQQLKHVTSVAKIEVCGLDMGSYISIDAFVKRCETLHRLDYAILNAGMGNATHRINESTGHEETMQVNFLSTMYLSVLLLPLLKQKSLSSNPGRLTVVNSGMSMHCELPEAKSDPLIPAFDAKATFDGMSHYAKSKLLGQLFIDKLARHVDPQDVIINCVDPGLTKGTGLMDKSPIVMKVFMTIMMRFLGRTQEQAASTYVDAAIVKGEEAHGSYVMDWRIYPAERQEVQGRLWKEMMNEFEFAGMEEIIDSMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I1S6F2</accession>
    <accession>A0A098DIM3</accession>
    <name>I1S6F2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T13003</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322223.1">
        <property type="nucleotide sequence ID" value="XM_011323921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S6F2"/>
    <dbReference type="EnsemblFungi" id="CEF78305">
        <property type="protein sequence ID" value="CEF78305"/>
        <property type="gene ID" value="FGRRES_12423"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12423"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13003"/>
    <dbReference type="HOGENOM" id="CLU_2097102_0_0_1"/>
    <dbReference type="InParanoid" id="I1S6F2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF78305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="116" mass="13111" checksum="633CBE616A7970C9" modified="2012-06-13" version="1">MLRRALALSIELDKELKQLEDWSTYNDRTLSTNTHRTSKFPATDKAVASYGKNVDTIDQKNADSKKGYQGRSCIGVGRDQGHHHHHARLATALQRPESRTGHGLVRRHNRVVIPCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1S734</accession>
    <accession>A0A098DYJ5</accession>
    <name>I1S734_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG04965.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T16759</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_011325137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S734"/>
    <dbReference type="EnsemblFungi" id="CEF86392">
        <property type="protein sequence ID" value="CEF86392"/>
        <property type="gene ID" value="FGRRES_12657"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12657"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16759"/>
    <dbReference type="eggNOG" id="ENOG502SCBF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_7_3_1"/>
    <dbReference type="InParanoid" id="I1S734"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="entry name" value="HET"/>
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        <property type="entry name" value="HetReg/Transcr_Mod"/>
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        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="Het-6_barrel"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="115"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF86392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="725" mass="81788" checksum="2B2C10DA13A6ECDC" modified="2012-06-13" version="1">MTSTNKECFVERKDLIQVHDHCPEQPYVELEIPHDAKRVIAVSFGGLSRDQANDPLEVIQSLSISSNASHYTHALNLDRQEIRLLHVKPGSFDDPISAHFSIASLKDAEAQNVDFDALSYCWGDSSERDEIFLSPNQNDTQDTPFSIGKSAAQAIRRLRLADETLAIWIDAVCINQDDLEERAQQVTLMTQIYSLASIVHIWLGEDNHGVEACLKLIRDICNYNSEICQGGDACSCAGTKHLTPLAEIKSFGEDRMKDGHKISFKGMFEVFEMHLKTWSQDIIDMAGWYGNTQLSFLMSTLYENSWFSRVWVIQEALSARVPIVHCSAEYVPWEEVVQVSNWLGHPAYAAQNPHNASQQISMAAIWKTLKPKGRTREVATTPVEADDKDQLSSILEVFLSGLDLKATDPRDKLFALLTFADETHDASQLDDLIRPNYDKAKERVFADFTRWWIREHNSVAILSSIHCQPTRTWVKTVGPTADTSNGHPTWSIDQKGSSRWTQANLNACLRFKAFGDTKPNLELLKTDDPLILRLSGLRITEIKRISSVPIEYMYPYQGSFDNQQEICKVLHQILDPCGLTPFWTRRNSAGDILQKTVQECNQKYIDHMNSHWAYSNRPALKVLKPNAKAELEYYETKKLPTCIEPCFFVTTSGLFGLCPWGSKEGDAIVLLDGGNVPYLLRPVEKEGDELRYELVGECFVQGIMHGEVVGALGANSDHKQVFTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1S8M0</accession>
    <accession>A0A098DUF4</accession>
    <name>I1S8M0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T25455</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327514.1">
        <property type="nucleotide sequence ID" value="XM_011329212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S8M0"/>
    <dbReference type="EnsemblFungi" id="CEF84488">
        <property type="protein sequence ID" value="CEF84488"/>
        <property type="gene ID" value="FGRRES_13198"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13198"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25455"/>
    <dbReference type="HOGENOM" id="CLU_836909_0_0_1"/>
    <dbReference type="InParanoid" id="I1S8M0"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF3">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124850" evidence="1">
        <location>
            <begin position="21"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF84488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="332" mass="37958" checksum="5EC208A492600BC2" modified="2012-06-13" version="1">MIEAAVGVEKLSSLLTLTFALHWFACQLTHKEMKKNTNPRNSRRIDVLYNPENDPEDPRQATVDIVAVHSLDGLGSNIDRPWSWPSDQPEKSVHWLHDKNMLRSEIPTARIMTFDYDSTWTSNAPQLLLESLGEDLIRSLHDVRHDQQRPVVFVAHGFGGEREFEDIIHCTAGFVSLGTPFRGTKIYWNAELVASIMRLCGTDRSIPSLLSYDNTRLRDKTHTLTSLRKVFPFPLFCFHEVFETTFTKLPPMLNFFKAIVVDEASACIPGDEQAHLQVNHDELNKYSGPEDKSYQIVSSEIAKMCKNTATVIKRQNDSDKSSPMYWGRYVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1S995</accession>
    <accession>A0A098DC13</accession>
    <name>I1S995_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T09341</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
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        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
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        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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    </evidence>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
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                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
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                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
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                <person name="Quesneville H."/>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
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                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF82819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328625.1">
        <property type="nucleotide sequence ID" value="XM_011330323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S9J1"/>
    <dbReference type="EnsemblFungi" id="CEF82819">
        <property type="protein sequence ID" value="CEF82819"/>
        <property type="gene ID" value="FGRRES_13522"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13522"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27787"/>
    <dbReference type="HOGENOM" id="CLU_2210292_0_0_1"/>
    <dbReference type="InParanoid" id="I1S9J1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF82819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF82819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="107" mass="11586" checksum="806E6E9007CCFF46" modified="2012-06-13" version="1">MTRSQLPYTPPEHRDRGNIWGGLESGCGGGGSSPRTLLQPQVCAGEYIELVYFPAMGSLVTDQSLQSNQAWPSDISTAIGTGYVYDAHDMTDIPWIFSMDTLRATGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1S9X4</accession>
    <name>I1S9X4_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FGRAMPH1_01T26193</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327861.1">
        <property type="nucleotide sequence ID" value="XM_011329559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S9X4"/>
    <dbReference type="ESTHER" id="gibze-i1s9x4">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF84215">
        <property type="protein sequence ID" value="CEF84215"/>
        <property type="gene ID" value="FGRRES_13655"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13655"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26193"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_6_1"/>
    <dbReference type="InParanoid" id="I1S9X4"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009997682" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="25"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="30"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF84215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="542" mass="60834" checksum="B567F49D09C34ECE" modified="2012-06-13" version="1">MATFGLLSVLQVLFLTAFIQITSAASPKAHTLNGTYTGKHLSGWDQDAFLGIPYAQPPTGNLRFKWPQSLNTSFDEERTATEYGDSCMQYTQNWTMSENCLSINVIRPAGKPKKLLPVLVWVYGGGLYAGSSADPQYNLSGIVKVSQDIKEPVLAVSFNYRLGMWGFLQNFSLLKEGNANAGLLDQRLALRWIQENIEAFGGDPERVVLWGESAGAQSIAYQMFSFDGQDENLYRGAILESGGITGAQIHDLSYYNVAFENLTRTVGCWDKKDQLSCLRGLDEKALYAARPSLTWNPLIDGTFLKGYPSQLIREKKFVSVPSIIGANTDEGFCVGAANTTEDLFYEAFRWRNYALSAPTIRKLLELYPDDPCHQPPYHITNCSRPVGNYQGRRSCAIGGDIAMISGRRKLAELFTESGEAVYSYRFDQRWYQRSEWEGVKHFDNVAFSFQNISGLLGPSPQYDSHAELAHNIGQAYVRFVNSLDPNPQGSSKEKVPKWPKYSMSKPKNMVFNATKSRVEDDTWRKEQIEFINSYAVARELYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1SAJ5</accession>
    <accession>A0A098E1C5</accession>
    <name>I1SAJ5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG11007.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T20997</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325362.1">
        <property type="nucleotide sequence ID" value="XM_011327060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1SAJ5"/>
    <dbReference type="STRING" id="229533.I1SAJ5"/>
    <dbReference type="EnsemblFungi" id="CEF87921">
        <property type="protein sequence ID" value="CEF87921"/>
        <property type="gene ID" value="FGRRES_13876"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13876"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20997"/>
    <dbReference type="eggNOG" id="ENOG502RXR0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040908_9_0_1"/>
    <dbReference type="InParanoid" id="I1SAJ5"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF14">
        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124858" evidence="1">
        <location>
            <begin position="20"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="2">
        <location>
            <begin position="55"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF87921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="283" mass="31005" checksum="7A03039B4E1E2528" modified="2012-06-13" version="1">MILMHTILSSVVVGSLVDALATPTQESPISARAASFIPGGKKAVSAGGNAVPFWKDHLGWWYDWTPAPTPVAGVVGVSMLWGSGQNGPQDSKRFSEFSNLNETPTYLLEFNEPDYSGQDTSANFGVSKGVELWNSLIAPKGQQGALLCSPAMCMQKDEKWLKEFSTASLSKPWDFTAIHIYKPDMTGVQADIDYYWNTYGKPIWVTEFGCVYDQNNFTPCSDQGQINKWISDIVDLFEKNEHVAAYAYTDGGGLGQAWLPTTDGGKKLSQSGQTYLSAISKYH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-06" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q4I5Z5</accession>
    <accession>A0A0E0SAF2</accession>
    <accession>V6RGA7</accession>
    <name>CGR1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName>rRNA-processing protein CGR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CGR1</name>
        <name type="ORF">FGRRES_07363</name>
        <name type="ORF">FGSG_07363</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS231666">
        <property type="protein sequence ID" value="ESU13618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327125.1">
        <property type="nucleotide sequence ID" value="XM_011328823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4I5Z5"/>
    <dbReference type="SMR" id="Q4I5Z5"/>
    <dbReference type="STRING" id="229533.Q4I5Z5"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T24635">
        <property type="protein sequence ID" value="FGRAMPH1_01T24635-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G24635"/>
    </dbReference>
    <dbReference type="GeneID" id="23554442"/>
    <dbReference type="KEGG" id="fgr:FGSG_07363"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24635"/>
    <dbReference type="eggNOG" id="ENOG502S7VB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125051_0_0_1"/>
    <dbReference type="InParanoid" id="Q4I5Z5"/>
    <dbReference type="OrthoDB" id="3942380at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000278956" description="rRNA-processing protein CGR1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="49"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="119" mass="14253" checksum="605DE587DE418826" modified="2005-08-16" version="1">MSDTENTNLTPAPAAEKTLGMRKNGKQWHAPKKAFRPTSGLKSYEKRSQERAIMIQVKAKEKEMKEEKEEERQRKVQAIKEKRAKKEEKERYEKMAEKMHKKRVERLKRKEKRNKLINS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q4I7T5</accession>
    <accession>A0A0E0SE02</accession>
    <accession>V6RE08</accession>
    <name>TIM14_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial import inner membrane translocase subunit TIM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Presequence translocated-associated motor subunit PAM18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PAM18</name>
        <name type="synonym">TIM14</name>
        <name type="ORF">FGRRES_06723</name>
        <name type="ORF">FGSG_06723</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to stimulate activity of mtHSP70 (SSC1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer with PAM16. Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The J domain is essential for co-chaperone activity and mediates the heterodimerization with the J-like domain of PAM16.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TIM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS231666">
        <property type="protein sequence ID" value="ESU12853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326360.1">
        <property type="nucleotide sequence ID" value="XM_011328058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4I7T5"/>
    <dbReference type="SMR" id="Q4I7T5"/>
    <dbReference type="STRING" id="229533.Q4I7T5"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T23005">
        <property type="protein sequence ID" value="FGRAMPH1_01T23005-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G23005"/>
    </dbReference>
    <dbReference type="GeneID" id="23553842"/>
    <dbReference type="KEGG" id="fgr:FGSG_06723"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23005"/>
    <dbReference type="eggNOG" id="KOG0723">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_13_3_1"/>
    <dbReference type="InParanoid" id="Q4I7T5"/>
    <dbReference type="OrthoDB" id="240298at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000071113" description="Mitochondrial import inner membrane translocase subunit TIM14">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="2">
        <location>
            <begin position="1"/>
            <end position="3"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="4"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="2">
        <location>
            <begin position="24"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="J">
        <location>
            <begin position="52"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="105" mass="11293" checksum="3B978003032CAB7E" modified="2005-08-16" version="1">MASVMAWGAGAAVAAFLGRAGLVAWRRSRGGVGAMGKAFYKGGFEAKMTKKEATLILSLNERAITKDKVRKAHRTLMLLNHPDRGGSPYLATKVNEAKEFLDKNG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q4I8X0</accession>
    <accession>A0A098E082</accession>
    <accession>A0A0E0SM52</accession>
    <accession>V6RDT9</accession>
    <name>TRM10_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(9)-N1)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">tRNA methyltransferase 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">tRNA(m1G9)-methyltransferase</fullName>
            <shortName evidence="2">tRNA(m1G9)MTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TRM10</name>
        <name type="ORF">FGRRES_06338</name>
        <name type="ORF">FGSG_06338</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="2"/>
    <dbReference type="EMBL" id="DS231665">
        <property type="protein sequence ID" value="ESU12419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324995.1">
        <property type="nucleotide sequence ID" value="XM_011326693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4I8X0"/>
    <dbReference type="SMR" id="Q4I8X0"/>
    <dbReference type="FunCoup" id="Q4I8X0">
        <property type="interactions" value="786"/>
    </dbReference>
    <dbReference type="STRING" id="229533.Q4I8X0"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T20071">
        <property type="protein sequence ID" value="FGRAMPH1_01T20071-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G20071"/>
    </dbReference>
    <dbReference type="GeneID" id="23553472"/>
    <dbReference type="KEGG" id="fgr:FGSG_06338"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20071"/>
    <dbReference type="eggNOG" id="KOG2967">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034384_0_0_1"/>
    <dbReference type="InParanoid" id="Q4I8X0"/>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
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        <property type="entry name" value="MT_TRM10-typ"/>
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        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000060516" description="tRNA (guanine(9)-N1)-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="3">
        <location>
            <begin position="120"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="353"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="287"/>
        </location>
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    <feature type="binding site" evidence="2">
        <location>
            <begin position="263"/>
            <end position="264"/>
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        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
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    <feature type="binding site" evidence="2">
        <location>
            <position position="283"/>
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        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
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    <feature type="binding site" evidence="2">
        <location>
            <begin position="287"/>
            <end position="291"/>
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        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
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    <feature type="binding site" evidence="2">
        <location>
            <position position="295"/>
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        <ligand>
            <name>S-adenosyl-L-methionine</name>
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    <feature type="binding site" evidence="2">
        <location>
            <position position="309"/>
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        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="321"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q12400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="407" mass="46769" checksum="30151BC819DC5C24" modified="2005-08-16" version="1">MDLDPAHKPSQAEETKEQGNEQGQVEQNQAQQDPTTGPQAETEKAIIPSQGSTIPQKRSAEDEPAQPMSKNALKRLRKQQQWEAGKEDRKLKRKDSRIARKVRKREERDALIAQGINPYANKQKPPSVNVPISLIFDCEFEQYMREKEIISLGSQITRSYSENKNAKYRTNIYVSNWNGKLAERFHQILDDKHQNWKGIDFVEGDFIECAEKAREKMKHENMIEPLQRSLTEKSPWARDEKDPLPLPDPEPEPRPEYSDIVYLSSDSPYTLERLEPNTSYVIGGLVDKNREKGLCYKRARERGIRTARLPIGQYMVMQSRTVLTTNHVVEIMLKWLEYENWGEAFMSVIPKRKGGKLKEQQGASGETQETEEAEAEDPEEENEETKDPDAEASASKQNTPKVEVTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>V6QUE6</accession>
    <accession>A0A098D047</accession>
    <name>V6QUE6_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG00365.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T00963</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316024.1">
        <property type="nucleotide sequence ID" value="XM_011317722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6QUE6"/>
    <dbReference type="FunCoup" id="V6QUE6">
        <property type="interactions" value="965"/>
    </dbReference>
    <dbReference type="STRING" id="229533.V6QUE6"/>
    <dbReference type="EnsemblFungi" id="CEF72284">
        <property type="protein sequence ID" value="CEF72284"/>
        <property type="gene ID" value="FGRRES_00365"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00365"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00963"/>
    <dbReference type="eggNOG" id="KOG1521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038421_0_1_1"/>
    <dbReference type="InParanoid" id="V6QUE6"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000003">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="7">
        <location>
            <begin position="70"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF72284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="381" mass="42539" checksum="4B7B28979BD2506B" modified="2014-02-19" version="1">MAPTQQAAWRNAPTAEDLARRQTVGINKETVTNISSTDYPGHHPGEDNEYTLDRFRDAFSVNFHQNDQFLSSFSLVGIDASLANAFRRILLSEIPTLAVENVYIENNTSVIQDEVLAHRLGLIPFKGGREGLHNFLKWHKKPEAGDDPYAGCFDWNTVRLELNVTCTVNEDASPTENDPLKAYHNAHVYARDIVFVPTGRQAEYFSGENAIAPTNPDILIAKLRPRQTINLAMHMHKGIGSDHAKFSPVATASYRLLPTITITQPILGADAEKFAKCFPKGVIGLEKVTAEDAAKTGSGYEGHKGETKAVVVDAMKDTVSREALRHEEFQGKVKLGRRRDHFIFSIESTGQWDSDELFLESVKHLKLKCKKLEQQVINMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>V6RUT5</accession>
    <name>V6RUT5_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP:AMP phosphotransferase, mitochondrial</fullName>
            <ecNumber evidence="5">2.7.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylate kinase 3</fullName>
            <shortName evidence="5">AK 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG09162.1</name>
        <name evidence="5" type="synonym">ADK2</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T27777</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:13749"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adenylate kinase family. AK3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.10" evidence="5"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328621.1">
        <property type="nucleotide sequence ID" value="XM_011330319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6RUT5"/>
    <dbReference type="FunCoup" id="V6RUT5">
        <property type="interactions" value="353"/>
    </dbReference>
    <dbReference type="STRING" id="229533.V6RUT5"/>
    <dbReference type="EnsemblFungi" id="CEF84875">
        <property type="protein sequence ID" value="CEF84875"/>
        <property type="gene ID" value="FGRRES_09162"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09162"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27777"/>
    <dbReference type="eggNOG" id="KOG3078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_1_1_1"/>
    <dbReference type="InParanoid" id="V6RUT5"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046899">
        <property type="term" value="F:nucleoside triphosphate adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046039">
        <property type="term" value="P:GTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046041">
        <property type="term" value="P:ITP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03169">
        <property type="entry name" value="Adenylate_kinase_AK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028586">
        <property type="entry name" value="AK3/Ak4_mitochondrial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="7">
        <location>
            <begin position="179"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="5">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="5">
        <location>
            <begin position="178"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="64"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="188"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF84875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="268" mass="29664" checksum="18139328BC49F6B0" modified="2014-02-19" version="1">MNLNKAARVILFGAPGVGKGTQSERLLSRFPQLNQISTGDLLRRNVKDRTPLGIKVENTMKSGGLVADDLILRLISNEFYTRGWLAKNGPPNVMTLSSEATALEHSFNSNAGVESFINAPFLDGHRPSDSSNDPSASFILDGFPRTASQAGPLDKLIPINLVVSLKTPVSVILERILGRWVHEPSGRVYNTSFNAPKIHGMDDITGEPLIQRPDDSEEVYRARYKKFQETSEPVLNHYAQKGVLVEIEGMSSDEISPKLFAEFERRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D1B9</accession>
    <accession>A0A0E0RNA8</accession>
    <name>A0A098D1B9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T01865</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D1B9"/>
    <dbReference type="EnsemblFungi" id="CEF72733">
        <property type="protein sequence ID" value="CEF72733"/>
        <property type="gene ID" value="FGRRES_11819"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01865"/>
    <dbReference type="InParanoid" id="A0A098D1B9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF72733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="167" mass="18392" checksum="82BC860065928565" modified="2015-01-07" version="1">MPISSTIRQVRYSIPYSREERHGSSSTVRTCSRDHIYESPESHAKLALAPQSSSASAWEAAPFLLTKSVANLLLGYLFPVPRAYHGTTPALSENEHKPRPDRTLACSKPKAPWRQGHPMGMDIIDPRNQGISVNEGILHLSDSIYPSHPFDDVGIVRVAQLHAALSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D2Q3</accession>
    <accession>A0A0E0RNA5</accession>
    <name>A0A098D2Q3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T01859</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D2Q3"/>
    <dbReference type="EnsemblFungi" id="CEF72730">
        <property type="protein sequence ID" value="CEF72730"/>
        <property type="gene ID" value="FGRRES_15775"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01859"/>
    <dbReference type="eggNOG" id="ENOG502RZE7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098D2Q3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="40"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF72730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="274" mass="29972" checksum="023B90314C5DD188" modified="2015-01-07" version="1">MAEQKDRWSTDAYQHSASFVPKLATKVVSWLDLQKDDVLLDIGCGDGILNAEFAKILSQGAGSMHGIDSSASMIEAAQELCKDHKNSTFDVLDATQLVSKPELQKGTFNKAFSNAAMHWILRPEEARAQFFDGVYAALAPGGTFAFEMGGLGNVSEMRAAILSSVARRVGLEKALAADPWFFPDETWITSALEAAGFKVERAEREWRPTPADKGGVEGWVRLMGSQLLDAVADEKEREEAAQECSSILREVCRNPGGGEMISYVRLRAIARKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D8S5</accession>
    <accession>A0A0E0RVS9</accession>
    <name>A0A098D8S5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T07099</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D8S5"/>
    <dbReference type="EnsemblFungi" id="CEF75354">
        <property type="protein sequence ID" value="CEF75354"/>
        <property type="gene ID" value="FGRRES_17304"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07099"/>
    <dbReference type="eggNOG" id="ENOG502REM9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098D8S5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="302"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF75354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="689" mass="78707" checksum="74FDD6E6C2CB9CAA" modified="2015-01-07" version="1">MEGYEANRKARLEHDHQWWGESHVEPAEGNPDRQHIYAHNPTISDQEFGEVFQAFRKSITNPETGELDSLSVHLRPATPPLEKATKQLQGLKDQDVEMSDELENEIIHQFTTNNGMVAALTEWCRNKLDVPVEHANQLMKMINRLNLEMAKQQRDLQFELDQTKTSLKESVEEAHNSKQNIATLEANLAKAKAESDVSGTLLKKSVEEFQDAKEELKEMTAFHDEVHRKLRAHAATWMATKNVYDKLSQDDQNARPEIKTLINKASLNWAELDSMYDRKWLPVAKALEQTDNRNGIGLLGLIEQKGEELRDKENEVGQLRETIAEQTTKLEQKDQEIERLKLKLHGMFSSKLSGIDTPEHSQYSSNTSMVSSFNSIQMEEEIKRLKQQNSGLQKMLADNSKGKDKDKDKDKASSSANTSLQDGDKLKEALEEIQNLRVQVQTQTGDIEKLNGIVNRKERVFEKQFGSPRQERNLYRNRLREVETAQFKTADKLILAIGKNDSASSIDRKMGLRDRINYLNLVCFFRTRNYIQLAIREGANRMANALLEDIEGWAKFCHKDFETMDPSVNILIEASIHILHDIRTIVTNDAEEDLKAAQESIQSARDVFQQYPIEGAFFQLDRLADQILQIAQEQAAESHTKKMRFIFADKLQVGRTRRTDIRSQVRNASGMKSAGFRLPGVHSPVSSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DAL6</accession>
    <accession>A0A0E0RUQ1</accession>
    <name>A0A098DAL6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG02643.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T06343</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DAL6"/>
    <dbReference type="EnsemblFungi" id="CEF74976">
        <property type="protein sequence ID" value="CEF74976"/>
        <property type="gene ID" value="FGRRES_02643_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06343"/>
    <dbReference type="eggNOG" id="ENOG502SHT7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DAL6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="817"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF74976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="933" mass="103131" checksum="F9E48D94AA904B8C" modified="2015-01-07" version="1">MADPYASSPFTYSDDHFESLQPPKRSHGINIFGNSSGYYSPLMMSSSETAGEGGQQQHHNQHEMSNFGTAPTSVSGLGISMGSAPSQSQSQSPDPNQHHRLSSPETPHSFHNLMSGDTPRHTPSQGSFSPRIADSQGTPEPYSEIWAPSMPRSRGNSQTDPSATETAKQIPTAQEREIMPSSSSAQKLPKIVEPRHDEMDDEFDDEIFYKKFAEPPKGCSSTRDIHQPRSSWLSITIYVLSVYSTVGSGIWLVTAILQPRWGHQIASSASLSPSTATTLAAMLAKTIEMSFVTVFVSCLGQVLTRRAFIRKAQGMSLAEMTMRNWVIQPGSLITHFETLPSSSLTLLGMLSLTATIAAAFYTTASDAMVSPKLKSGSWQHKELEGYVKASYANAGYVREDCPYLFNITEDIHAAESCMNVQFSGQSYRNLLNYMTVWTNINQNGTEISADPKKRPGGTTLLFDNTTMFSEWIETEHSDVAAQFEETGRIINNVTLALPHPGVYGAATLKKNGILQPDDLAGVGEYTIRAGVVAPSVNVLCVDMDKTELAPLVYTTWPHAKNNNTVIPGQKTGWTGWTGEIPQPLDSKNKPYYLNRTDVDDIFKWGPKYERRPPVFQMYPFDYNLLANATVYEADAIYTLGKSAESKNYTLCQLRSWVSPNCSTEFSISGTAGARMNAHCEDDADENAYRRSFPADQGWSLPSLDWKWLADQWRLSMDLNGGSVNNNASNARILTQLALNKPKMPASHPSMAEALAVYSSSLIMISAIDTPFRHYWDQDPDEFPGNLIKEGPGFLQAFNASMITQEYTSGHTQGWQNIFYVVLVLVFAINLFCLGYFIMRSGLVTDFTEPQNLFSLAINSPPSNNFHGSCGGGPEKKQLVVPWKVAFAPSANHYFFQDESSGKEVAAEATTTAREYQKPLQSSYKRLSMSRTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DDZ6</accession>
    <accession>A0A0E0RY51</accession>
    <name>A0A098DDZ6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T08747</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF76176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DDZ6"/>
    <dbReference type="STRING" id="229533.A0A098DDZ6"/>
    <dbReference type="EnsemblFungi" id="CEF76176">
        <property type="protein sequence ID" value="CEF76176"/>
        <property type="gene ID" value="FGRRES_13815"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08747"/>
    <dbReference type="eggNOG" id="ENOG502SQ24">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DDZ6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF13">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="13"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="428" mass="49333" checksum="779DD02BAEB89760" modified="2015-01-07" version="1">MAKTTTINLNDFMTNIPWVQLSSTYQDAITICCRLGIFYLWIDSLCIIQDSKDDWKDQASQMADIYESSFITIAATRSNDGSEGCFVECDEKYLAKLVPGYRNIYVRQMPPLFPSDWCIPRNCNDWPLLNRGWIYQEMMLSQRILHFCANEVRSESGGNDHQFSQFRDRRVFRKLPYRRVPYAILRQEPRYLWYRTVQEYSRLQLNFESDKMPALGGLTKRMQTMRPNDRYLAGLWEKTLLFDLLWSVWPGPVAGRRKNPQFPSWSWASVSCQVMWHDLVDSTLDSVRVEEVRLLNTGPSHLGELLEAAITIRAPFTDASLFRPQWRSLPVDVSNDNITRVDQLCVYDDEADCLPYNLSAARYNPEPGPSTTNDVFAAIHVQLRPGGKCYERIGYGKICHPSTLILDTEAASVKEMLEALPTSTIVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DFJ6</accession>
    <accession>A0A0E0S142</accession>
    <name>A0A098DFJ6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T10829</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DFJ6"/>
    <dbReference type="EnsemblFungi" id="CEF77217">
        <property type="protein sequence ID" value="CEF77217"/>
        <property type="gene ID" value="FGRRES_15512"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10829"/>
    <dbReference type="InParanoid" id="A0A098DFJ6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF77217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="87" mass="9521" checksum="47DDADDE0BEE37BF" modified="2015-01-07" version="1">MTIGDESAFVAVPAYLRSTVPYNLLPVTCKGYVELGVFLWNSQGWCEAFPGPSTRANLKLPHSVQILPFLHLGQSTRDSPPDCQTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DFU0</accession>
    <accession>A0A0E0S2V4</accession>
    <name>A0A098DFU0_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG03095.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T12051</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DFU0"/>
    <dbReference type="ESTHER" id="gibze-i1rh52">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF77829">
        <property type="protein sequence ID" value="CEF77829"/>
        <property type="gene ID" value="FGRRES_16328"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12051"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DFU0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009993900" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="29"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="356"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF77829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="488" mass="52942" checksum="CCE6D298D14BD20A" modified="2015-01-07" version="1">MKLPSSCLLALVAGSSALNIPSHHDAPLTIKTTSGELTGFINETAPSVRQFLGVPFAEPPVKSLRFQPPRRLHGKGSISAKKYAPSCKQALSNAPTVYNQYMTQFLINGGQSEDCLYLNVYAPLNPTSKRLPVMIYIPGGGFTGGGADSLYKIPDKWIQKTQAHIVVTMNYRVNVFGFPNAKDAHQNAGLLDQRMVVEWVRDNVAGFGGDPNQMVLWGQSAGAGSVGMYGYAYPKDLIVKGLISDSGAPSMLVKPYGNYTDFDTIASKLGCMAGSKQLECMQKVDASELQKVYSETAGVSFTPVGDNTTAFSNTTDRLARGLVTKVPWIFGNNANEGAGFGTYNKSGVSASQLAIGLAAIVCPVAAEVENREKYGYPTYRYYYTGNFSNISPLPWIGATHSAELPLIFGTHYEYRGNSTEYEWQVADGMQSLWLSFAKNPTKNGIKGDGVTWPLYKPDQKKMAVLAEAGKKWFQLGPESLTDEQCSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DHL0</accession>
    <accession>A0A0E0S1R6</accession>
    <name>A0A098DHL0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T11277</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DHL0"/>
    <dbReference type="EnsemblFungi" id="CEF77441">
        <property type="protein sequence ID" value="CEF77441"/>
        <property type="gene ID" value="FGRRES_11592_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11277"/>
    <dbReference type="InParanoid" id="A0A098DHL0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF77441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="177" mass="19713" checksum="688CC42056033D02" modified="2015-01-07" version="1">MSLVGEVQGYSDRIFRQLATNDVRPVDNARKPGDVSHSGQEQSGAISWCIVPRVCRDDEVGGMEEQEQHLEESVSLANFNRLKAKPAVVATKEDASVITALNANLKMCLNWNGVLTVIKVGSPLLYLVSRPVMVVEAFKGGTQSYILYLGFITVTNITERYRYCIIFNALNESQEHY</sequence>
</entry>
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    <accession>A0A098DI92</accession>
    <accession>A0A0E0S3U5</accession>
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        <name evidence="2" type="ORF">FGRAMPH1_01T12735</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A098DI92"/>
    <dbReference type="EnsemblFungi" id="CEF78170">
        <property type="protein sequence ID" value="CEF78170"/>
        <property type="gene ID" value="FGRRES_20170"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12735"/>
    <dbReference type="InParanoid" id="A0A098DI92"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    <evidence type="ECO:0000313" key="2">
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DJU8</accession>
    <accession>A0A0E0S6V3</accession>
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        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
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    <gene>
        <name evidence="3" type="primary">FG04256.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T14853</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DJU8"/>
    <dbReference type="FunCoup" id="A0A098DJU8">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A098DJU8"/>
    <dbReference type="EnsemblFungi" id="CEF79228">
        <property type="protein sequence ID" value="CEF79228"/>
        <property type="gene ID" value="FGRRES_04256_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14853"/>
    <dbReference type="eggNOG" id="KOG0634">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A098DJU8"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.640.10:FF:000080">
        <property type="entry name" value="Aminotransferase, putative"/>
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        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
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        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
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        <property type="entry name" value="Aminotransferase_I/II_large"/>
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        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
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        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
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        <property type="entry name" value="AMINOTRANSFERASE"/>
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        <property type="entry name" value="LD15494P"/>
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        <property type="entry name" value="Aminotran_1_2"/>
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    <feature type="domain" description="Aminotransferase class I/classII large" evidence="1">
        <location>
            <begin position="134"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF79228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="556" mass="61120" checksum="54D56B726A789E8B" modified="2015-01-07" version="1">MAVPQLIRYRSVGLVGGISKYKSSEVIRQKQRHFCNTSAYKASILSHYTTASPLCRNRNIRCSTPPPASSSYSHAAKMRTKTTHASEVASDPQSGKHQINLIRGWPNPGLLPVDLISAAAQRNLSDPSIYVPALQYGADPGYQPLREALATWLSEHYHVERDPNRICISGGASQNVACILQSFTDPHVTQAVWCISPSYHLVFQVFRDNGFDGRLRATPEDEEGVDVETLEAKIAEFEKNAPEAKPPLSDAGKDRKHYRHVIYAVPTCSNPSGKTMSLRRREALVRLARKYDALIICDDVYDFLQWRIDSNPNQVSARVDDQEHPEMLLPRLCDIDLAMGQADNDPQGFGHAISNGSFSKLVGPGMRTGWLEGSPAFAYGLAQTGATKSGGSPSQFCASLMADLLQSGSLQDRLATTIRPQLQHRHRIMMEAIHKHLGPLSVGIRDAGLPEGLVYGGYFVWLTFEEGISAKVVSQAAIAEENLVVGNGTMFQVPGDEKTVHLDNAVRLTFAYIPEEDLTEGVERLAGVLRRIKENPEKYKASASTTADSDIINANK</sequence>
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    <accession>A0A098DKH9</accession>
    <accession>A0A0E0S635</accession>
    <name>A0A098DKH9_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
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        <name evidence="2" type="ORF">FGRAMPH1_01T14315</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DKH9"/>
    <dbReference type="EnsemblFungi" id="CEF78960">
        <property type="protein sequence ID" value="CEF78960"/>
        <property type="gene ID" value="FGRRES_15218"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14315"/>
    <dbReference type="InParanoid" id="A0A098DKH9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF78960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="211" mass="22778" checksum="BD6682641379B833" modified="2015-01-07" version="1">MRLQKTGLLILNTTPLVVILLFTTAGSLDPWQSLVLVAIACARSHGLDRTPLQRNHDISQALDKGLSLGLLQRLLALQLINPDIQRMQSNTHGVLSQIALLVERELGQDAYNGLDVAILPFALPQETHVRGENATDEKKKLFKTEDVDAGPLKAKDGPEGAQPRDGTDGLQGEEEIGEIGCETLLGERTVGHPEGIEETFPELLGVDVGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DMV4</accession>
    <accession>A0A0E0S9S8</accession>
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        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
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        <name evidence="1" type="ORF">FGRAMPH1_01T25359</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DMV4"/>
    <dbReference type="EnsemblFungi" id="CEF83191">
        <property type="protein sequence ID" value="CEF83191"/>
        <property type="gene ID" value="FGRRES_20374"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25359"/>
    <dbReference type="InParanoid" id="A0A098DMV4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF83191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="159" mass="18432" checksum="E563779AA640195D" modified="2015-01-07" version="1">MSFKIKYLLSIFPFTVLECRSLGNRKRRRRVIPDESPQATSTQYNKKLQAPTNNIPVLDQPARDPLHAWCNKSLSFCFQIWIDRVYQGEYRQQSQSQHDCYQDLDDGEKNGDVLCSFKDFESCGDKRGDLVEGRVDLFGVGHAHLDGIRCCDYRDGFEQ</sequence>
</entry>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DMY9"/>
    <dbReference type="EnsemblFungi" id="CEF83231">
        <property type="protein sequence ID" value="CEF83231"/>
        <property type="gene ID" value="FGRRES_16846"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25099"/>
    <dbReference type="eggNOG" id="KOG1287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DMY9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000042">
        <property type="entry name" value="Similar to amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF402">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="164"/>
            <end position="180"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="315"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="335"/>
            <end position="357"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="432"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="456"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="468"/>
            <end position="484"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="508"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="517" mass="55763" checksum="1DE2F6CC47245708" modified="2015-01-07" version="1">MPPDQSEDVAARQPLLSERDENVSSDASRESRTRGTFTRNLGAAEAFGIVVSIVIGSGVFTSPGSIDTNVPSPGIALAIWLVGGILAWSGATTFAELGTAIPGEGGVQPYLQHIYGDIWGFLAGWTWIVAVMPATLAILSIVFVESAYSAAGVINEDDRIEHKLLSILVLVVMSVANSISTKASTRLNGFFVVLKFLSILVVVVVALAVVGVHVAHPNKEVGGGDWYKKSWFKYRDTYNPNGPDTDWSKLSQWEIFGHYSAALYAALWAYSGWDKAIYVSAELSQPARQLPLAINTSIPTAIICFLAANAGYYILLPWNIVSTTDSVAVTAITRLLGQGFGIVTAILICLVVAGSLLGNSFVASRMCVAAARKDWIPSLFTIVGRVGLKPAEEETAAADEQSKDTGDAPINAVILSVILASFYILFGSFRALLTLNGLGEYSFFFLTVLGAIILRYREPDLERPYKTFSINPIVFVIVSGFVVVRGAIFAPVQAVVIMAIWVLGLVFYKARQYWASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="10">Guanine nucleotide-exchange factor SEC12</fullName>
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    <gene>
        <name evidence="12" type="primary">FG06652.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T22837</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Fungi</taxon>
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            <taxon>Sordariomycetes</taxon>
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    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the WD repeat SEC12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DRI1"/>
    <dbReference type="STRING" id="229533.A0A098DRI1"/>
    <dbReference type="EnsemblFungi" id="CEF83954">
        <property type="protein sequence ID" value="CEF83954"/>
        <property type="gene ID" value="FGRRES_06652"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22837"/>
    <dbReference type="eggNOG" id="ENOG502S8QF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DRI1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 10" id="KW-0813">Transport</keyword>
    <keyword evidence="2 10" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF83954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="596" mass="64076" checksum="2326DEF5B1F2AF80" modified="2015-01-07" version="1">MASSFPRSSIQLDYPLYAIDFDPEDATRVVVGGGGGAGRSGVGNKITVLETVSQQELRSAGEIALSRDEDSVMSLAVGPHKGKSTYLYAGVNSSPESIAKGKNEHLRALSVDPSKLRTSVGAKTPDTNITEASRTALFQDPEVDTYQRLLRIAGSTGVAATAMSKEPQLAIFDVAGAAVKLLSVLKIEKEAEDLDIVQTGENEFQIAYCYKYELWLVNISGKEVSEPRRVYVMMDDHGERPAFRALRYLSPNFLVAATNLPKRSGVVIQAFRLPKLEQAEARLCLNARIPRKISATAFAVANLSPPSSPFGALGETQFVIAVAGHDCSITLYTLEHTVGGSIELLSKLWHLHTLKEVHGNANITAMAFSHFVTPKNNLRQQYIKLASTSLQKTVVVNSIALKKHVEKAPRNKKGPPRAARYVTAVKSRGVSSRGLGITMAIFALLMALVAQAVLELSGQNTPILGVERIFPAAWHGSLRAPDHPPTAFLADEFLAKLGGRDIVKTVTGETLVVYEGDLPPATAGGDGQVPELKLDVHEPSVHGPGMTWEELGEEQKEAWKARLKEAGAWTQTMGEAVFKGILFGEIAGAVGRAVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DRJ4</accession>
    <accession>A0A0E0SDF8</accession>
    <name>A0A098DRJ4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T23185</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DRJ4"/>
    <dbReference type="EnsemblFungi" id="CEF84471">
        <property type="protein sequence ID" value="CEF84471"/>
        <property type="gene ID" value="FGRRES_12989"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RMRM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DRJ4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF84471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="167" mass="19742" checksum="E8F3B642F82A6B77" modified="2015-01-07" version="1">MELAALKDQDPTHILFRRHVENGSLCVDLEANYIERDATVLRQMIKSGDKGLEEYQQRFMARLVRYYQFVCQFSKIMDFDEPNGVFLHSSLYLAKKHWGEEKGIHLRAENEDWASLHRTDKPDQWICYLVHHPLSRYMMRAMKLVSNEGGIMITFISERYASCYIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DSZ2</accession>
    <accession>A0A0E0SC00</accession>
    <name>A0A098DSZ2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T27685</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DSZ2"/>
    <dbReference type="SMR" id="A0A098DSZ2"/>
    <dbReference type="STRING" id="229533.A0A098DSZ2"/>
    <dbReference type="EnsemblFungi" id="CEF83963">
        <property type="protein sequence ID" value="CEF83963"/>
        <property type="gene ID" value="FGRRES_17174"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27685"/>
    <dbReference type="eggNOG" id="ENOG502QRWG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DSZ2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050151">
        <property type="term" value="F:oleate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010354">
        <property type="entry name" value="Oleate_hydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37417">
        <property type="entry name" value="67 KDA MYOSIN-CROSS-REACTIVE ANTIGEN FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G09970)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37417:SF2">
        <property type="entry name" value="67 KDA MYOSIN-CROSS-REACTIVE ANTIGEN FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G09970)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06100">
        <property type="entry name" value="MCRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF83963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="572" mass="63724" checksum="6DE937DD0AEEA422" modified="2015-01-07" version="1">MEDNHGDPKVTPDEDNGVISLSNSPGSSNGSDPNSPHIWLVGGGIASLAAAVFLIDDVNVPGSHIHVLEASSKAGGSMATFAKPSWDTGYRVSAIRKMSLTYHCLYGMLEKVPFETEGETLAARFRRFNQESKKLGASGSRLVRQVFDENGAEKPEAVDVSTMGLSVKNQCDLMRVVLETEEELEGLEIQALFEPDFFETNFWDLWSSLNRFHPWCSAVEFRRCLHRMLHEFPNMGTLSGVEQAPEEDFQAIIKPLTQYLKASDVEFRHGILVSGLEIEDIGSDFRVTALKTYQDSKHVQLTLGPDDIVLLTLGSLTSGMGYGTNDQPPPTMELRDSAPHALDPSWAFWDKLALERPQTFGNPEAFFDRPSKSTWLSFTVTLRDPAFFEHLCKWTGTLTGAVPLLTFRDCPWMLSLTIPQQPYVKDQPDGVFVFWGYGLFPDQQGRYVRKPMLECTGAEILTELLHLMAFPIRPTLDRSITVPCLMPLIGSPFLTRKKGDRPKVIPDGSKNLGLMGQFVEIEREVTFTMEYSVRSAQLAVYGLMGLDKQLPGVQGEDHEVLTLGMALKTMMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DTV9</accession>
    <accession>A0A0E0SCV0</accession>
    <name>A0A098DTV9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG09146.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T27821</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF84263">
        <property type="protein sequence ID" value="CEF84263"/>
        <property type="gene ID" value="FGRRES_09146_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27821"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DTV9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF7708" evidence="3">
        <location>
            <begin position="85"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="260"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="805"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="867"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="970"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1006"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1150"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1179"/>
            <end position="1211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF84263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1374" mass="153849" checksum="2CD6CF1E3FC0BB18" modified="2015-01-07" version="1">MASLWDHAFQNLSAEDKDTLRPEDTELQPKAMDITKLVETAKENCERKQWVLYKDDQGKEVKFRDKLEEVVGLFEKFIAAGDAAVSYDPAHAALPWAAVRALLQTYGAMIEGVKAVSTIVFTYTTIETRVLLRESQVTKQLSASLVTLYSSALRFLASATRYYSKNTFKRLMSSLHRNASSVVEAPILVIEKQEKEVYKLVSLAEREVQGTDLQKIITLVESSVRTSGEINQERRTRLSAWINGIETNTTFERACNRHPGTCDWPMAVEAFKTWASEDGPMPCLLWMHGPAGFGKTFMSARIIQYLQQEKQCPLAYFFCVADNELTRDPYAILRSWLVQLLDQGDEMLSTILTQAEKLNMAQALTQHRLWELFAAIGKKFDRCTFVIDGFDECTHIDQGVRYHHQEPRNIFLDELLKSLSGTNSRVLLVSRDVPDIREHLGQDTSNGNNKVQKLEYCITAKDTSEDIESFAKFTVDDKLRKKSTKVRNNIATRAVDRSDGMFLWIELLGRKLMPSSNEKTLVKTVTEMPAGISDAYANELEDISQRPTEEKEQSVMILRWVLFAVVPLQVKQLAEALLVSSPELSEYPDDDLPDEWEQEFVDDCYVKDNILGRCGSLLQIRSSSPDTPLGDQTVHFVHFSVKEFLTELSNTEPRNDWATKLGLESTSIEETRLSDVCLRYLTLERFHDIPQEPERYPFLSYASWAWYFHSFHEKPSPSTQIISRTQEAFNPKASGWKVWTPLMEAKIIESDLGKWGGYAHGCEDLFKVENPIYYASLLGLIDIVKWLEGQGLECSCAGGGRFGFPLQAAVARGHLELVKYLLLRGVNISQEGGQFGQSVIAAAVISNVEIMQALLEAKADAKSKDLRGWTSLHYAAKNGNTAMITLLLKYGADINAQTYDLWTAASLACRYKHKDALDLLAKNGADLNPQDTITAVPLKIAIMSGDSSLVLAVCNMLRYSNIDPHEIVIEGLTPLELAIGLGNIGIIDALIDDGAACNGVSNLTAEVNSPLQVAIMNSRTSTAETLIRKGAEIDRAGRDGTTSLICAVECEELETVEWVLHMGASGQGIRENDLKTAFDTALGYYDLDIARLLIRRGCFRLGSQEPTPDPATEVMRESFVMHAFDGTLDMVVKDLAAMSSSLSPDLLTEALHVASSRGHLSIVQRLIQSGAKVGSRDINKRSALHHATFHCHFDVAECLLEQGASISMEDIVGSSPIDLAIQNGLKAFDFIQSHMSDLTLTISRRPSLLTGPLTQSRSLSSMEVRRVISGLWDGFYEYLSWCEGVREPFSIEISDPSGLDSQNKAFSNQGYDEGGMFKFYGFVDPIGIIWFVKLYERLGWLYRGELNVEKRVIKGKWGSNRKLWHGTFRLQLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DWT1</accession>
    <accession>A0A0E0SH94</accession>
    <name>A0A098DWT1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG07761.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T25587</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DWT1"/>
    <dbReference type="EnsemblFungi" id="CEF85807">
        <property type="protein sequence ID" value="CEF85807"/>
        <property type="gene ID" value="FGRRES_07761_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25587"/>
    <dbReference type="eggNOG" id="ENOG502RKT0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DWT1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF85807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="208" mass="23157" checksum="2EE25FFC1DAAA811" modified="2015-01-07" version="1">MTRIAWNDDGDVSSISSGDSAHTLSSSDFEILDMDEPMSSFETGIMTPSESSFSFTPPGTPSTETIFSAQEKWDDLVVTYRQAVNQVRQIEDEMANLRYQSLQPHISMDVERFNAHQRSQPQIAMQSLYDINDDMQPSRRCDSTHATLNLVPGAHQLNVELSEAVELSIVQLDTLSGKKTMISLTAKSSGANLKQLLGFWEFCMPLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0S0V3</accession>
    <name>A0A0E0S0V3_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG08718.1</name>
        <name evidence="4" type="synonym">AIM11</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T10653</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AIM11 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0S0V3"/>
    <dbReference type="EnsemblFungi" id="CEF77128">
        <property type="protein sequence ID" value="CEF77128"/>
        <property type="gene ID" value="FGRRES_16983"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10653"/>
    <dbReference type="eggNOG" id="ENOG502S3SI">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A0E0S0V3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038814">
        <property type="entry name" value="AIM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
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    <feature type="chain" id="PRO_5010027119" description="Altered inheritance of mitochondria protein 11" evidence="6">
        <location>
            <begin position="19"/>
            <end position="210"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
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            <begin position="14"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF77128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="210" mass="22684" checksum="103BEABA6E351145" modified="2016-04-13" version="1">MPILASLVSSWLGVPAASDHKPTPQQNQEATTPYRQASPKTGSIITATPTPQASPSSSTTPAHPQSTWERSIRQMGLLLTGAGFLAASVAVSRRSVLRMRKDSLPKFYSSNQNPIKVDMGERSFLAAQALGLATLNVMSFGVMLVGGISWAFDLASIAELRERTQAAVRRPGSVNPEDEKAMEELMEELMGKLGMEKPQKPSDTSEENEK</sequence>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0S5V7"/>
    <dbReference type="EnsemblFungi" id="CEF78882">
        <property type="protein sequence ID" value="CEF78882"/>
        <property type="gene ID" value="FGRRES_16175"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14159"/>
    <dbReference type="InParanoid" id="A0A0E0S5V7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
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        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
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        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
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            <dbReference type="EMBL" id="CEF78882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="398" mass="43488" checksum="39B833F3B6371C4D" modified="2016-04-13" version="1">MVNILLKIGLSVVVILAVLFQVYLKEAVWLGLGIGKVMQPISDFPYACRKIVDPRMEACEDMWLSQSTRQLFLVCSDPIARDAWFPNVGALNISGRSQRDSIVALDIDKPVGTSFEPRTLKTEGFAGTSGDGIINIAGFTGIDNSDGSIDLLVTNMRPSVDAESGNYLDQFVHGANTTVEHFTTGAGPNELKHVRTFADAGITTPNRVAVMDDKTFYVANDHGPHMMGWRHHLSPILGFANINVCKPNTPCKEVSSSLKFPNGLAIHGNTLYVPDSIRGTLTIYNILPNKDLKKVDEIKLNYGLDNVSIDENGDLWIAAFPVGIEIYKANKDPYNAHPPSAVLRVRKVDGEWKVDKVLEDKDGEVLPAATTALHDAKTGRIFLSSVISPWITVCEANA</sequence>
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    <accession>A0A0E0SBC4</accession>
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            <fullName evidence="5 13">Chorismate mutase</fullName>
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    <gene>
        <name evidence="16" type="primary">FG09602.1</name>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <reaction evidence="12">
            <text>chorismate = prephenate</text>
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            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13898"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="FGRRES_17718"/>
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    <dbReference type="eggNOG" id="KOG0795">
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        <property type="reaction ID" value="UER00203"/>
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        <property type="component" value="Chromosome 4"/>
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        <property type="entry name" value="CM_II_prokaryot"/>
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        <property type="entry name" value="CM_pl-yst"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145:SF12">
        <property type="entry name" value="CHORISMATE MUTASE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017318">
        <property type="entry name" value="Chor_mut_AroQ_eu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51169">
        <property type="entry name" value="CHORISMATE_MUT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="14">
        <location>
            <begin position="152"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
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        </source>
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            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023979"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR017318"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01817"/>
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    </evidence>
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            <dbReference type="EMBL" id="CEF83737.1"/>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF83737"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="273" mass="31317" checksum="F767F4681EFF8A4F" modified="2016-04-13" version="1">MDTVINMADAAHALDLARIRFQLMLGTDSRSRLEDTITFHLIERVQFALNSTIYAPGAVELPESNLSFLDWYFREQEKLQSLIRRFESPDEYPFFPDALQKPILKPLNYPRILYENDVNVNDKIKAFYTEKFLPAVCPDFGREERGESQENYGSTATCDIACLQALSRRIHFGKFVAESKFRSEQEKYIRLIKAEDREGIAESITNAAVEKQVLERLRLKALTYGKDPSIPDGTEGAAKINVDAVVSMYKDFVIPLTKEVEVEYLMQRLEPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SBV6</accession>
    <name>A0A0E0SBV6_GIBZE</name>
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        <submittedName>
            <fullName evidence="6">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FGRAMPH1_01T25089</name>
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    <organism evidence="7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SBV6"/>
    <dbReference type="EnsemblFungi" id="CEF83919">
        <property type="protein sequence ID" value="CEF83919"/>
        <property type="gene ID" value="FGRRES_16845"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25089"/>
    <dbReference type="eggNOG" id="ENOG502S1DJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0SBV6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
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    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010027148" evidence="4">
        <location>
            <begin position="19"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="37"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF83919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="404" mass="44330" checksum="B9DC1F08295D16F0" modified="2016-04-13" version="1">MRFFQTLSLSALLTLGNAAAIAKDSKVKVPELPNTDYDAVVIGGGPAGLSALSGLARVRRNVLLLDNGLYRNGPTRHMHDVIGFDGVQPAYYRYEARRLLSYYDTVKMENATVVDIKAQKGDYTSFSLSVDYPGQDTKTITARKVVLATGIKDLLPDTPGIAENWGKGIFWCPWCDGHEHADQPLGLIAPLNKVAGLVREMATLNSNVYAFVNGTDNSTTQALADQDLPQWREYLKLHNVTVDNRTITEVKRLKNGDTHNADPSLPSVPEFDLFSVEFTEGKPVERAAFLTSFPDEQRSDVGEKAGVTLYGGRLQANGSAGLITNVPGIYAIGDANTDNTTNVPHALFTGKRAAVFLHVQLERETQAVELAGLPKREAELQERDLWETMNGKRGEMLYAGEFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SGX2</accession>
    <name>A0A0E0SGX2_GIBZE</name>
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        <submittedName>
            <fullName evidence="4">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG09755.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T26345</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SGX2"/>
    <dbReference type="STRING" id="229533.A0A0E0SGX2"/>
    <dbReference type="EnsemblFungi" id="CEF85685">
        <property type="protein sequence ID" value="CEF85685"/>
        <property type="gene ID" value="FGRRES_17267"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26345"/>
    <dbReference type="eggNOG" id="ENOG502RN7K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0SGX2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="416"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="655"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF85685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="965" mass="101423" checksum="D9505CF0EEDC2E8D" modified="2016-04-13" version="1">MAYSLTNSFIGESFLSGFEWFNGTDLSKGFVQYQDFTGAFKNGLYSVDPFSETVQLRPDSRHKYGLDEGRPSIRLESKESYQYGLFIADFQHMPISQCGTWPAFWAYGSNWPMGGEIDILEGANLAYTNIMSAHTAEGCMLDPADSNLFSGIRRNLDCGVGTNNVGCGFNPPKSDTSSYGDGFNAVGGGVYAMEWDSEYISIWHFPRGAIPADIEAKQPDPRNWGLPQSLFGGAKCDVDKYFSDMKLVLNINFCGDYGEGTWANSKVCKALAPTCREYVANNPTAFKEAYFDVSYIDVYTRLGGNIPPILPSSASEASTQASDVIITGESATTTPMSGRPVFPSTNFHDNSTIATRTDRKGKATQSEEPTTTTTLTMTGISSVLVTIPGSGTDTPTVTPLPVATGGKSANPSKIGDYSYLGCFGSQNGFQTFDLADDSDDMTIERCVDACNGLTYIGLFEGTCYCASVLDGDTLAISNETSCNRPCPGDDAQFCGGMVTQNTRTRFRRTTPLRRDAPSNVLLTVYADISDVELPEVPPAMGPGTNDISTDDGDSQGDSATDESESPTTSDDKASQGASDAAEPENSGDSDATTSQESTNADGSEDLTASNDNGTQGGSTTDDPDDSTASDGNASQRGSESEDSKILPVLNDNIDASLAGSASSPGSSAQGSSDEQDSSDDQDDPDSYGNSILPSAAGVVLSDDQDTSPVAVIGTASDGLVLGATQSAADSNQELFLSTITYFTVMPSNPGSLVPQQGIITMSYEKCDYCETPELIKPPMETKVVDCDGCGPNGEDTVTLTVPISVTVTVPGASTEQAQQTEKAAAEAVTSYGGSPEQPPRNSTILPAVPNGMGSGAEAGESPEVTTVVITYLTTQLVTYGTSTDSVSTVTRTARRTVVITVSDSDGQMSILPISSPGQPNTPVTIATPTPGAPSEPVAISAAASRRDDVFVYFAIVAMAILALTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YHY3</accession>
    <name>A0A1C3YHY3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T00225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB63985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YHY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00225"/>
    <dbReference type="eggNOG" id="ENOG502RJBN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YHY3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008687526" evidence="2">
        <location>
            <begin position="20"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB63985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="259" mass="26439" checksum="EC19F02EF8DB8AF5" modified="2016-11-02" version="1">MRLLLLATGLFAANVVVEAGVCKPAQTTASHSDAVSSIESSATSASATVIETTSLSMTETTSAEPTETTAPGTTLATTTSAEVLSTSVTEAPTTTTTEEASTTVSSSTAPYFTPGSVVGSGPVAGLTLQGVDQRFIPLSFQQSGTTQTLIFSLANGKLATGTNNNNLCLAYKDQGVLAPLVLCPFDNFENAPLSCQQSSDGTLACSAPGGYCNAARTCTRPNNAVRLSQFYVNDAQEGFFGPASGDFAGYTALNLVLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YIK0</accession>
    <name>A0A1C3YIK0_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FGRAMPH1_01T04553</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="10"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YIK0"/>
    <dbReference type="STRING" id="229533.A0A1C3YIK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04553"/>
    <dbReference type="eggNOG" id="KOG1950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YIK0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000092">
        <property type="entry name" value="Glycogenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="272"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="600"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="658"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="694"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SCB64319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="704" mass="78503" checksum="E32511412B09704E" modified="2016-11-02" version="1">MTAQNAKGEQIYATLLLSDSYLPGALVLAHSLRDAGANHKLAVLVTLDSVSGDSITQLKEVYDYIFPVPRIRNDHPANLQLMNRGDLHSAFTKINLWRLTDFSKIVYIDADVVAYRAPEELFNLSQPFAAAPDIGWPDLFNTGVMVLDPNMGDFYAMMAMAERGISFDGADQGLINMHFGQQYHRLSFTYNVTPSAHYQYVPAYRHFQSSINMVHFIGANKPWFTGRDAPAGSGPFTEMIGRWWAVYDRHYRHQENSATQYVQYFTKGEWRPQSVQEQPSTNEQHQHDDHSANSTGQQQHGEQDLEDQHQADEDEEKDEDETHHETPGRHPITMHDWDAQKYPPPSDSKPEALNFPLTHYEMSRDTTPFIPPQRYPSPPQNMWYEVPKDRSSPQSKHAPEIFPWERNQPRPTRTFAGEPQPEPQPSPEETSAQLSVKTEGITESGSESKNQSSSSTPTVQVTSSSPWTSYTRTNAWDEVPAIERYVDRLHGGGHRRGKSSTSSTGRVKSPTTGTWRDDQTSSKQGLKLTDFPSAVERPSLPVTPAPVHRNSFFTEDDAENEDETKKKLPEAEGVPTQSDWDPIEQLQKLAKQQSDALLKRLGGDGEEGGVSREIPARPLPFGSGDGKSPTYVAQSASGVLSPQPMKGERSAGVLRDMSSGSPQQSTIPQPSYSGPGAAWEKGEDIPLHETPLLSKEKGLDALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJ18</accession>
    <name>A0A1C3YJ18_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T06651</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJ18"/>
    <dbReference type="STRING" id="229533.A0A1C3YJ18"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06651"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJ18"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="251"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="318"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="353"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="386"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="451"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="485"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="518"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="551"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="630"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="694"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SCB64492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="767" mass="83871" checksum="F4A009DC53A7E725" modified="2016-11-02" version="1">MMDLQNRIKKADLQDLIDICEQLSKECRGFSNCLNTSPVVLAALAKECRAITDALDRLHELSRTIEGGTESVKASNNGFVYSVSKDVHELRAALKRIKGPDRDSGIHLNEPQLIIVWNEATLKEYLGRLRTHQASLHTLLNTATRASYSFGESDLNRRRVIEPDIEVDEALRSLGRKFTTPTQRSIVLPRVSDSTEIQILLDTLVPHPGIDYVQTKDVAHELHHAIEQTDESAVFNILLERADPNITLAGSMLSPLHRAFDKKHMLIAAFLIVAGADVDEPTTDGDTALMRSIKCGFSEQFARLVIHMKVRINSIDNNGRSALHFSAASDVLEDETLPTLINAGADINLVDYEGHTPLHVAIQHAHWSAATKLVQAGADLEVRLPDGKTALHLTIAMRNQEFTQVLISRGANVDRKLREHTPLTMAISTRCTPITAALLDMGANPNLPSRNGNTPLLAAAATGHDETVRYLIAHGANPTETHGQSGYTPMHMAAHKDKPHILRLLAESEAPIDVLDRNGETPLLIAAKLGNSQSILRLVNLGADIERVGPDGMSVLSHAVKMGDVDLVTALLELGAGMQMTSMFLSRCSREYLVPEPQTTPIHVAAQHARDEILLRLVSYGASLESTIFPGRTPLSVAASHGHVSTVRLLLRLGANTQALTTHGDTLLFEASANLATLKILLQQGINVNHQNDRGATALHYAALRGHMGGVRMLLEKGARQYHANAVWDVWEDRDGAGGYRQGTPAGMAMQRGLDNIAEFIEGWKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJC7</accession>
    <name>A0A1C3YJC7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T06845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJC7"/>
    <dbReference type="STRING" id="229533.A0A1C3YJC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06845"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJC7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SET_LSMT"/>
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        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SCB64515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="467" mass="52128" checksum="0224F4F05857E588" modified="2016-11-02" version="1">MPPKLTLPIDVFPAWARFNDVDFINAKLCETDRKGIGLVTVTGSDLTKIPVTEGEANDKDLQHGKAEALLRIPHDLVLSASTVEDYAKVDQNFRQLMDSVGHNSTRGNILLYLLAHLVLSGRDASNPRGPASTPWTEYLKFLPRDVPVPTMWSEVERALLQGTSLEAALEAKFASLSKEFEDLTDKSSVLPFWNSLFWEKGTVTIQDWILVDAWYRSRCLELPRGGDAMVPGLDMANHSHHPTAYYDEDDKDDVVLLVRPETTVSAGEEVNISYGDKNPAEMLFSYGFIDNESTVEGLNLPVKVLPDDPLGKAKLHIFGSLAYLKLSRSDGEVSWQCPFAYLMCLNEEDGLEFKVLQGEDGGRELRLFWQEEDVTAQVGRFEDLIKDHPLCQIFKLRVVSVLHEVVSDHLVELSSEISHDELEPLRRDGLVRDECIQAAEKLRGVEAGVLESAAVALDKQVRIARSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJD0</accession>
    <name>A0A1C3YJD0_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
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    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T16471</name>
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    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJD0"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16471"/>
    <dbReference type="InParanoid" id="A0A1C3YJD0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008687596" evidence="1">
        <location>
            <begin position="22"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="320" mass="33475" checksum="A8CBB8B86C053EE2" modified="2016-11-02" version="1">MARHGIVALLAATLLGASVNAGPCKPYSSVALSSTVIVEPTMTGSSTITADITGTTDALETTVTEATTDVTDTTDALETTITEPAIETTGTLETSVIKTTAESTTDLVETTTTETAIDTTGSLETTSVDTTDVPDTTTTEAVVDTSAVTIETTTTAAAESGCVPTQILANPSFDDNTNGAPWARGLDVSVSQDNPRSQPNFLYNTVVTVSAYPPMFYQRLPALGSSTYELRYWYSLRTAVLGNGFSCTVTPSLNTQVLSSSLTMTDNSSHGFQLSSQYFTAQNPDSPAVLVFNVNCKGNFQSVSIGVDDIALTRLCDGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-01-24" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJK1</accession>
    <name>A0A1C3YJK1_GIBZE</name>
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        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
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    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T07997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </evidence>
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    </evidence>
    <sequence length="177" mass="19932" checksum="7BE885CE4328185C" modified="2016-11-02" version="1">MYYREFDVCKQWLYKTVDIPFNINFNSSTFTHRSSITTATMGLSHFALPCGEHYVEMRDFYKAVLAPLGYEFKFEAQGPTGAYYCAFGEKNKGPDFWLGGGGSSLKKYDGNMENRTCPVHFAFDAENPKHVDEWHEAAMKAGAVDNGKPGPRNYRPGYYAAFVLDPVGNNVEVLHLG</sequence>
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    <accession>A0A1C3YJY1</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="SCB64848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="KOG0936">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 3"/>
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    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="AP complex subunit sigma"/>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="EMBL" id="SCB64848.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="protein sequence ID" value="SCB64807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A1C3YK83"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18483"/>
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    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
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    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
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    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
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        <property type="entry name" value="EBP"/>
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        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
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        <location>
            <begin position="74"/>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="146"/>
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    </feature>
    <feature type="domain" description="EXPERA" evidence="7">
        <location>
            <begin position="7"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SCB64807.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="177" mass="19967" checksum="ECCD8FE1308FD189" modified="2016-11-02" version="1">MAQKPLRDWVYLVMIIPQLIGMIVLDFTEFYPESLYVSPKAPLHFLTIIRDTYLSLSGDPFYGPAFSGEWLRSMYYIELFVQFPLAAYVVWNMASKKPTSGPTELAGLAFGCLTAMGSVACVAELLAMGPEMVNDQQKLTLAWGTYFPYAFIPGVMAVDMYMRLLRRVSNDTKSKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKI7</accession>
    <name>A0A1C3YKI7_GIBZE</name>
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        <submittedName>
            <fullName evidence="10">Chromosome 4, complete genome</fullName>
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    <gene>
        <name evidence="10" type="ORF">FGRAMPH1_01T22387</name>
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    <organism evidence="10 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970335">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22387"/>
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    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="18"/>
            <end position="48"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <end position="106"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="EMBL" id="SCB65059.1"/>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="660" mass="74306" checksum="8357C1760C621577" modified="2016-11-02" version="1">MPEAAPQNPNPRKRASVACNGCRVKRTKCDGTQPQCSACGDRRQDCEYTQAESNRKRHTNAYITALEARVASLEKQLAMHAKHPESPDSMDNCGPVDEEAVPPTTDPSFSLAPVDPAPDEMDELTNSLGCFTLGEIGELRYFGASSNFSIISNHAIKIPSSLQARNRGIEAARAMPGFFEPTDQLRDELLTIFWKWQNSWQYIVPRELFVRDLYVDHAGRYCTPLLLSAILAFCSRYSRRPELRTDPYDANTAGEAFAAQAKTMLHHEYDAPTTSTVQAAALLGLYWASIDNEGLGFMYIGMASRMAMNLGLHCDCSSYAVKSLISEDDVEARTVTFWGIYVLDKLYCLGMGRPASIQEYNITTSKPKGNVPHSPLLTDDQLTSTSPYPIPHITENAMYTCEVLMVTSEVIDQLYAQRYAWTDKEREDRVMKAHLEAVGLFDRLPKSLKISNSSLQCSPPYVYQLHLQYHHAILLLHRPFFQLLNPGKNSIFYDPEGRDIHSQSVKNSAVRIARILQIFRKNYTMQCMPISAVHPAFTASIIHLLHIKSSGDIGRTEAMRCLSICIVSLYEMNVSWNWANRSIRAVQSLAAEWEIDIWAHGLAQEITEESRLQFERYETDDLPVARVEDVGTAQGISLDDIFESWAYGQCFGESSLNFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKK5</accession>
    <name>A0A1C3YKK5_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FGRAMPH1_01T20699</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKK5"/>
    <dbReference type="FunCoup" id="A0A1C3YKK5">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YKK5"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20699"/>
    <dbReference type="eggNOG" id="KOG1612">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YKK5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="35"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SCB64963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="338" mass="36906" checksum="4A580C3155173A6F" modified="2016-11-02" version="1">MASQQNLFSPAELAYLHQSLSLRPPIRPDGRSPTQFRPLTAETGVLPGTNGSARVHFADGTEAIVGVKAEIEKTGGSQEQNDDQDRSRNDWLELAVEIPGQRDDEASTVFLAEMLREALLADNEFAKKLRINRRFHWRLYLDVLLISPPLSYPLPLLSLTTHLALLATRLPRLKSEGDEDPMFDDDWESSTFLYPRDGAEAEGSRPPITLLVVAIGDNTIFDPAKEELAVAESALAVSVAEVRKIKADGEMDVDKKGRELKLLSIRTVDPPSRLTPPGVPHITNNSAQKGEAQTTEGVWKAPLGGTKFGVMDGIIQSVLEKGGVVDEVLDGLEGVELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKW7</accession>
    <name>A0A1C3YKW7_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FGRAMPH1_01T23973</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKW7"/>
    <dbReference type="FunCoup" id="A0A1C3YKW7">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YKW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23973"/>
    <dbReference type="InParanoid" id="A0A1C3YKW7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SCB65189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="465" mass="52066" checksum="B82235EAA343E712" modified="2016-11-02" version="1">MLLRTMASANTLRCLIRPTIPRAPRIQPVLLAPFSTTSSVLAVSAPPPIKSRRDLPQKVKKSYKKRANVAPVRKPQPGERKAFRKRIQLSNNSALPVQGLETLNATNMTNDSSAGKVFAMPDQVVDHLRALEAFKTTQTWNLFRKPHVLLRKETLELMKKLELSVKEKKALKCVLIGSKLSGKSMAMLQAMSYALLNNWVVFHIPEGQDLTNGNTEYSPIPDTEPPQFSQPIYCLKMIQSLYRANRVILEKLNIEQDWSKFTNLKKGATLADLALSAKEAEYAWPTLLALWTELTLPGRPPVLFALDGLAHINKISDYRDAAFKQVHAHELTLVRLFIDALSGKVALPNGGAVIAATSENNSHHHPSQELVLSQLEAGQAGREVPKPNPYERKYDERVYDALKNSWVLRLEGVSKDEARSLMEYWGASGLFRHVLNSRTVSEKWTVGGHGNVGEMERASLMQMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YL14</accession>
    <name>A0A1C3YL14_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T22449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YL14"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22449"/>
    <dbReference type="eggNOG" id="ENOG502QPPB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YL14"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF6">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G00280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="30"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SCB65062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="332" mass="36952" checksum="8031C5F65CFECBD0" modified="2016-11-02" version="1">MKETPLELSIENLRALNRLNDPSIPSTMPQNILILGAGELGICVLEALSHHSNQQHRVSVLVRQATLDSAAPDKRKLVQRIRALNAGTEGADVVAASVEDLAAIFKKYDVVVSCNGMGLPSGTQVKLLDAVVAAGVKRFFPWQFGMDYDIIGRGSSQDLFDEQLSVRNKLRAQDSVDWTIVSTGLFMSFLFLADFGVVDLSQKIVRALGSWENEISLTTPQDIGRVTADIILDPRGIARQVVYTAGDTISYGRLADLLDERFKTEFKRELWDLELLKKQMEDEPSVMVKYRDTFAQGRGVAWDKKGTVNVERGIEVVDVKKYLEMMDFKVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLS3</accession>
    <name>A0A1C3YLS3_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FGRAMPH1_01T26315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1C3YLS3">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YLS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26315"/>
    <dbReference type="eggNOG" id="KOG1020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YLS3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23958">
        <property type="entry name" value="SCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026003">
        <property type="entry name" value="Cohesin_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12765">
        <property type="entry name" value="Cohesin_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="8">
        <location>
            <begin position="1440"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="152"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1789"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1816"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1854"/>
            <end position="1863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SCB65374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1863" mass="207221" checksum="7859550AECC4366C" modified="2016-11-02" version="1">MNNMHPNKHGGPSNGLFAQTGANDNNPAINRTRPFTLQEALPYSPQTSTVPFIPDIIPDPVLGSGCPALPLNDLFQAHEFNSLNREAAAHPQMPRNVKQAVEHVLQDIKPSQRTHYKFTPISKTIASQPPGKSLMEGLSPVTRSVFDKVGGYFKTTKPGAPEGKQLNGQAGGHSTPKQRSSSANSPNPPQPHALPVHNSQAYKSNSVRIEVVVPSKRQFDPSTYVDVDSSVAAAQQVHQQPQQQHTQLLSQLPTPFAQSSAQDHMETNQNGTFRIELPRANINREEYIEVKERPEDLHHLSVRKQSQQAYSDSQDLIGESLDQRQRSEAALHALEKLMRTVFNSVGRALGDEQGYEEVVSMTPDQEVAMTASSQQKMHGAIQKAITLKCFDQVPVEHLVQIMKLSDASLKQVENLELRVDETWNEEAVDAWVQQLSEVETMLKSARTCLRILSGGREDKQLYSETIIQKSVDIFRKVTEDIVMPLVELRPSGPASGVFKTLSKSKKPITSVFLCCQKLFALLAELVTKIELSETVINSLEYTASRLIFMENAYFEKDSVVGVQKFDGLRSVAMDMLSQIFLIKPEQRQGIFDEILTSLEKLPVGKQSARQFKLSDGGSIQPVSALIMRLVQASSGRVDDNKDRDRHKLLRNIDGEQGGSDDDDSAPSGVKQFVSSIKSEVQGAKQHSVAIRDLEISVAPLTDAAQRNASYVISFIVKRAVGSTKSGDTPYRNLLDLFVEDFTTCLDSPDWPSAELLLRLLMVLMVQLFEAPKTAAPAKNMALELLGGLSAAISRLRSHVQRLTNSSEGNEADGLSQYLADLVNQALDHKTRVEQLVAWAGPYRLVLEYVQNRSNEDPHLSSAISFLVAGWASQVHTGYDSYNDEDEERDEELGRMAYRVRMMVEDRRWLVNEYTFKSVSPNQAKLSYSIILLRSPLCEAFSKILNILLGSMASDQATVRSRSLKSINQVLETDPSILDGDSTVIDLILECAGDPSIQVRDSALGLLGNCMAMRPRLESSLTPMIVNRFQDNGLGVRKRAMKLTRDIYLRNPSKTLRSMIANGLLRRVQDPDDTVRDLARQMIEEVWFAPFYQGEGTAVYQTSLNEHVSLVIQTVKSGTVTEMLDKVFRSILKPKDKSLSGPFTVCTKLVANMFGLIDNLDPEDPTVPSGRDALQVLTIFANAEPKLFNFEQIRLLLPHLANFSKPEELAAFRHVTIVYRRVLPTLTSVHTEFLSEVRAYLLKALSKVSQRNPLDDLVACTQVVCGLLNVYTPLIGGLLSSLLKIEQIQARPIDQNSITLTYGYSLLIGMIAKHCKLDEWTNTFRAKFPKWKGDSVPLLAIEKLVPLAASSKPLEIRKSALDALGLICQAWPRNYVVPKLYTLFDQVFKEQTPGLEMLILRSFREFLLTEEKRSETGAEGPAAGKKRELTVMGGTNFDDVASATSQRFLKYISRIALSGQGDHAFLATEVLGSINRQGLTHPKETCVTLMTLETSTNRRISELAFSEHRYLHEKHETVLEREYAKAVQSAFAYQRDIVEDTRGATTNPFQSKLHLLMEVLKISKMKNRQRFLDKLCGQLDFDLAKLDAAEEVPSHMAFARFITENLAFFEYQSVGELQTTVNAIEKMVTSTGASLAQAIESEIFNVRVDTLQSLAPEASAPVPGVSANLTPGVLPMEVDPKSALAMASEVEPGRLRQLATASIILLSMWETRTHLRRLYGMGNSRHDSKAKALAKDLNRIPVKVQGVHGDKVWDEIEAHMAGLQDQERMIQKCTALVELLNVDKEFKIADDGDQMDMDPSTPSGDDDEDGDSTLDRGRKRKGANTPGGRKKRARSDSQPRKRGRPRKNPLPESDVGADLDESWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YN88</accession>
    <name>A0A1C3YN88_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FGRAMPH1_01T15443</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YN88"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15443"/>
    <dbReference type="eggNOG" id="ENOG502SI1U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YN88"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="259"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SCB65969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="621" mass="69859" checksum="9C5AB3E48DA55775" modified="2016-11-02" version="1">MMASGYTGDFVGDYIGRPNNRDDAMSIDSPPVKPSFFGVTGHNEIFEETKNYLSKLEAFSINPEDTSISGTQASNAIKFKDLPPNIQQTCLAVLGCIFGPCYDRLVAHKTKYENRLWSNLTVPAIIRSLESTFGSHLNLEKVDLEVIAERICNNTIRPFRDTENSQEWAGQLCGQNLRWESITMLWSVLRRIPNSFEPIERQKFHILENGTLNKATLAFLRHGISLARYFTIANVMILDLLQQKTIVESMIIGDASLAVWNSHGEAVAMMTYLGVHAQRSITPYTPSLSSEHKRRLFGRIYNLDKAIVAFTGRPPLLDPRYCTTQMPLDLSDEDLLAGGAALERAAAELNPGGWNTHGGVYPSGFCRAAYQISVILSEILGIALAPDPNTTLETLSNIKQRELNVIAQFPKHLIYDPNDPHDLPLPHAEPAPHEKDLSDPQVETNVIPLRIFTRLTHLQNMFLLERLFLQNGAVDEGDVLLVSFEMISLTLLFWTHKDKFRDIRRDFEWMLMAFAVPGGGILCQELLEPTFQGRHPKDSRLSRSSIIQKLSLLVGFLDWVHPSAPNGDLCASCKTVMQRVLDYQLNGAVNELGSLEHFSSDLMGRLNFNFELLNTFDWLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1R9H8</accession>
    <accession>A0A098D1Z6</accession>
    <name>I1R9H8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG00119.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T00333</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF71966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315721.1">
        <property type="nucleotide sequence ID" value="XM_011317419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1R9H8"/>
    <dbReference type="EnsemblFungi" id="CEF71966">
        <property type="protein sequence ID" value="CEF71966"/>
        <property type="gene ID" value="FGRRES_00119"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00119"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00333"/>
    <dbReference type="eggNOG" id="ENOG502REJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_636227_0_0_1"/>
    <dbReference type="InParanoid" id="I1R9H8"/>
    <dbReference type="OrthoDB" id="5102121at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF5">
        <property type="entry name" value="DUF6590 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF71966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF71966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="431" mass="48369" checksum="4CA6062B1C66422D" modified="2012-06-13" version="1">MQEYASHVPLPESDASVSEPDSDVELPSRFLDTSEVYVYVQNWLPEPSKEPIPRLAGTLFEAILALFIHLTHYVAIEKDGKHIALGSRELVQEVERLFLWGDGFSASSGQLDEILSKSSELRQSVLSSLYELGVTLKNTALQTRYTSHGNKTRGLDIPMRELRGLLEQTSILLYGSDNLDDRDAISESESSTNDLTKCIEDISIYIDCLMDLSVALENPVLDLEPVNATIPSSQNLETFDVSSSQASTFCRKIRDRFPKMEKWLVERLGENNARRASALKEAHERCLDIEATNSTNVSDPVLEDSNTASSRQPAPMREFPHIPASNSSFLTRALAITDGPYTCTIRTCILDTKSYKSTRRWVEHESQHRPQDWQGSECPFCDSKSTLMSPKSYYKHVAEHLREISLAALPHSFDSHTDTTSSNDNSEDNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1R9H9</accession>
    <accession>A0A098D0K2</accession>
    <name>I1R9H9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG00120.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T00335</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF71967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315722.1">
        <property type="nucleotide sequence ID" value="XM_011317420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1R9H9"/>
    <dbReference type="STRING" id="229533.I1R9H9"/>
    <dbReference type="EnsemblFungi" id="CEF71967">
        <property type="protein sequence ID" value="CEF71967"/>
        <property type="gene ID" value="FGRRES_00120_M"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00120"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00335"/>
    <dbReference type="eggNOG" id="ENOG502SXH3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_771719_0_0_1"/>
    <dbReference type="InParanoid" id="I1R9H9"/>
    <dbReference type="OrthoDB" id="5331891at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF71967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF71967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="359" mass="40118" checksum="C8FF982228C50277" modified="2012-06-13" version="1">MSGFEIVGVVLGGIPIVLEAYNRYQAVSTTLTSTLSTVTQDAEKARSLISGDGNWDALGLEGLDLTRLETMRDALDSWKDTLDVIHDSLQAICSEIDSFRVSPCTKPTKILSMEILRKQFKLFVKKDTMQEAIEDLRNFTADFNRITSQIIDELKDPGLGNSSLDRISARIKPSCWNSLKMYQQIRAASSSLYEALALRWPCALHQRHMASIAFQEGYRAPELGKGIKFEAVVTPSESEAFPLWLEIECINDTRTSQPTIPSVTQLEDDKAWVTVVDTLNKHSQAMVLDSTKGKPKKLTKQQIPSQMPKTPKVANVVPVQILSWNPKIPEKQDTANSDETPLTNMEIIGDICHHFQTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>I1RA20</accession>
    <name>I1RA20_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG00337.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T00883</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315987.1">
        <property type="nucleotide sequence ID" value="XM_011317685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RA20"/>
    <dbReference type="STRING" id="229533.I1RA20"/>
    <dbReference type="EnsemblFungi" id="CEF72244">
        <property type="protein sequence ID" value="CEF72244"/>
        <property type="gene ID" value="FGRRES_00337"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00337"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00883"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="InParanoid" id="I1RA20"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="PHI-base" id="PHI:1244"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000257">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000153">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="16"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF72244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="407" mass="45149" checksum="4B74B6DACDC5F6BA" modified="2012-06-13" version="1">MDSAARQQPQVQPCRYKVGKTLGAGSYSVVKECVHIDTGRYYAAKVINKRLMAGREHMVRNEIAVLKKVSMGHQNILTLVDYFETMNNLYLVTDLALGGELFDRICRKGSYFESDAADLVRATLSAVAYLHDHGIVHRDLKPENLLFRTPEDNADLLIADFGLSRIMDEEQFHVLTTTCGTPGYMAPEIFKKTGHGKPVDLWALGVITYFLLCGYTPFDRDSDFEEMQAILNADYSFTPIEYWRGVSAHAKDFIQRCLTIDSTKRITAHEALQHPFVAGFINAEGESQNLLPNIKKNFNARRTLHAAIDTVRAINKLREAQSGLMDGARSKEPSRGAAQQTPTNRKVDSAISIGNNQPKDSGYGTQTENDVVMGNTSASNVPSSLQPGNNGNRVIETSKGLWSAAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1RAI9</accession>
    <accession>A0A098D1X7</accession>
    <name>I1RAI9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG00519.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T01323</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
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    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
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    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
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    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF73664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="286" mass="32048" checksum="266584415BF6992C" modified="2012-06-13" version="1">MFSTSRRHESSTKSFSKGHKASKSSASFSKDSGISKRKHESRHSRRPTMTSMTSTSGDTTMGDNMASPIVTLVVGSEQRLFAAHEDVLSNSPFFNHALRNGYMDSASKRISLPDEEPEIFSSVLEFLYKGDYTPRLVHNKRRNSYELETASEEQRAAVESTVYHRGIDGDLLKDTVIYCAAEKYGLDELKKISLRKQGLQSGIQCSTILASARYAYANTPDTDSKLRAHYLALIIRSRSTFKRSGTMQLEMYNGGTQLFFDLFVALCNHVDDISTAQNTPRSNRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1RDA7</accession>
    <accession>A0A098D470</accession>
    <name>I1RDA7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T03905</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317418.1">
        <property type="nucleotide sequence ID" value="XM_011319116.1"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF73759">
        <property type="protein sequence ID" value="CEF73759"/>
        <property type="gene ID" value="FGRRES_01599"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01599"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03905"/>
    <dbReference type="eggNOG" id="KOG1216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_255327_0_0_1"/>
    <dbReference type="InParanoid" id="I1RDA7"/>
    <dbReference type="OrthoDB" id="5119629at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF73759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1385" mass="163676" checksum="5ADB988D47DBD5C2" modified="2012-06-13" version="1">MKTSLFYALNGALGAVAHESLAYFKIDSGKEEHRSLDGCSKHGKHKWVPDPSTFVFPQNDYKPGNSWDLCVDSAHCAPHEALSKVTFDFKDNGIIFNFKHIEHYKYEDVVVYVERGKPPTEYSQKYSKDSDHCKIISDYKKAKCHIPYFSLTDGGSYDELCPIKDNGGWRLYVKIKAKISHGYKKYSLFSRAGDIHEKYFTLSYTCAECKEYKHKEGKYEVIEEVEDYPEGEKKKYDEYKHEKEEKKYNDYEEEGKEKYKRGVDEEEETEYKEKEKEKEFRHEHHHKHHHHHGHQHEHKHGHKHGHLHGHLHKEHHYNHHDKHHGYGKGHEHKHYGYDHHDPNYLHEHKDYNHGDHGHHYDEHKHYDHYGHGHHHHDDYKHHEHYDPSRHHDHDSFLNDFFKKYGHYDYHHGKHHHEHHDGYNHHHARDLADDEIKKSEKDEYKHKHGHKHGHHHNHNHDHHHKHRHSHHDYHHYEHYDPGYHYDHKHHDYKNYDHKDYKHYDHKHHDYKHGHHNYDHNDYNYYHKHHDNKHYDHHHGDKHYGHHHEHHKHYEHHDPSYHYEHHKHYEHHDPSYHHEHHKHYDHHHGDKYKHHPKRSDEHHDKHHGKHYEEPVTVYYKEKAEDVNAKANHVIYEKVQKHEIPAHIYKKLAEAKKHQYDHEHKYGHEHKHAEEQYHQKKLAEAKLSKAIEEYYALHYGKQHNEHKKHEPEKKYYEQKEFENKKEHEYKKHGPKAYYEHNKYGHLNEHKHHDKHEEYEPERYNHAHYRHKEHKPKYDSDPYHDKKAFLKDYKYDGVNIHSTWEKLYKAKIEHDHKQKQKAYAVHFDKHPPFYKHSSFKRSALPKYYHGDEAVEIDTAKVEKYIEKAEYRINEGISKAIYKAINSAGDDPSTGTIIKFVNKVEAAIKYIVAKNLKKAVAHIAEIHGIEEPSADEVEKYIYKTAKHILKAADEIFTKTIDALGEDPNEKEVEYAVAKVEKLLARVVDKYVREAIVGIFDLEYVTENSYGEYEKYDKRQVANAQNVTASANSTTAANDTAPATNAISTKAVNRLMRLFMRQDSQNATQAANTTAQAANATETQTLMRFMRRQASKADNVTEAAVNATSQAANVTAEAANATETQTLMRFMRRQASKADNVTEAAVNATAQAVADVDQALNTTAQAVNVTQAQNSKRTEVYSDSKIEKVVEKAAEKAADKLINKLDKEESKSQSKRDAKFYNGYLPKCKGKIIKAYGIDGLHSGPLKDFSVKSHPNTCHNHQGDYVVYSHDELKKTVYGKLYESHGGDNKFGNYFIELVKGHDSYTKDIVVSIDISDKYQYEATEAKVFIGCSAGFDHHSSDNICSEKTYPYLAVAEKGLNEFVFAIPDKYMCHEYYIAIVVDFCDTKYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I1RDU2</accession>
    <name>I1RDU2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG01809.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T04383</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317649.1">
        <property type="nucleotide sequence ID" value="XM_011319347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RDU2"/>
    <dbReference type="FunCoup" id="I1RDU2">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF73998">
        <property type="protein sequence ID" value="CEF73998"/>
        <property type="gene ID" value="FGRRES_01809"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01809"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04383"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_1"/>
    <dbReference type="InParanoid" id="I1RDU2"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF15">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF73998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="341" mass="38398" checksum="5C35EBA039A163B0" modified="2012-06-13" version="1">MDKMEYVKLGNTGLKISKVILGCMSFGSSKWQGSPWVLDEEDGLKLLKAAYDNGINTWDTADTYSNGESEVIIGKALKKFNIPRQKVVILSKIYNPVMDDGTRPPSVNDGPLVNQMGLSRKHVFHAVDKCLERLGTDYIDVLQIHRLDRETPPEEIMRALHEVVQSGKVRYIGASSMYTWEFARMQYIAESKGWTKFISMQPFYNLLYREEEREMLPFCEATGVGVIPWSPIARGLLAKPLSSKDDNQSIRSQNDKKTDTWFADANLDIVNRVEKVAKDKGVSMALVSTAWVLQKGCYPILGLNSEKRVIEAVDALKVTFTAEELEYLESAYKPRGIQGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>I1REM5</accession>
    <accession>A0A098D8S3</accession>
    <name>I1REM5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG02117.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T05101</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317993.1">
        <property type="nucleotide sequence ID" value="XM_011319691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1REM5"/>
    <dbReference type="STRING" id="229533.I1REM5"/>
    <dbReference type="EnsemblFungi" id="CEF74356">
        <property type="protein sequence ID" value="CEF74356"/>
        <property type="gene ID" value="FGRRES_02117"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02117"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05101"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_9_0_1"/>
    <dbReference type="InParanoid" id="I1REM5"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124130" evidence="10">
        <location>
            <begin position="24"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF74356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="509" mass="58011" checksum="B9AA29DBEF52DEEC" modified="2012-06-13" version="1">METYLLVAIALAVVFLVNHKTSPKVPSTIPRLQDSSPFLPFKLYWRYLTDCRRLFLEAYQEFTKDGKTCVLPSMGFKDEIHLAHHHTQWAASQPDGVLSPFEGFREIDKGDWNSGHASYIQDPWQSVVIKKEMGRFLEILASDVDDELKTAVPEYVKPGPNDEVDVYESMKWIVAQVSSRFTVGLSLCRDKTYLKDTLEFADLFILNSGLLIYTPSLLKPLVGFFITLPTRYNRWKIQKHIQTLYEERTKRLLNPELYEKSEEPTDNLQMMMKYAIDKHRDQVTLSQISNRLCLANLASFHQTAVATSNVLINIAASNAEFNTIEVIRKEMADVLGENGVFDKASVSKMVQTDSVLRESMRTHGFGNRAMIRKVVSPGGLKTPDGQTLPNGSTMSILSYPVHNDPTIYEHPEKFHPFRFSQMRSEGNGANLSFVSTSPTYLPFGHGKHACPGRFLVDFEMKMILHHVLKEYDIELLPEHNGVRPESHWITEAVMPPVGVKLRFKKRVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I1RF04</accession>
    <accession>A0A098D6F2</accession>
    <name>I1RF04_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG02266.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T05469</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318171.1">
        <property type="nucleotide sequence ID" value="XM_011319869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RF04"/>
    <dbReference type="EnsemblFungi" id="CEF74539">
        <property type="protein sequence ID" value="CEF74539"/>
        <property type="gene ID" value="FGRRES_02266"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02266"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05469"/>
    <dbReference type="eggNOG" id="KOG1200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="InParanoid" id="I1RF04"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF124">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF74539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="273" mass="29165" checksum="7C12F0C1621CA118" modified="2012-06-13" version="1">MKITYGTRLKDKVCIVTGSSSGFGRAIALGYSLEGALVVCADLQQGARADVNGEQAISTHELIKQKGGKAIFVQTDVSKNDAVENLVYRAVAEFSRVDVVVNNAGISIESGKPSRRIHDTPEEWWNTTMAVNLKSIFLLSKHAITQMLKQEKNEAGDRGWIINIASIFGLVGGYALPSYVASKGGAQNLTRSIALDYAKDGIHCNAICPGFAETALLADAVKIHDKEAIRSKHPLHGLGTAEDIVGAAIFLASAEARWITGVRLPVDGGYTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1RGS3</accession>
    <accession>A0A098DI58</accession>
    <name>I1RGS3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG02948.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T11685</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322850.1">
        <property type="nucleotide sequence ID" value="XM_011324548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RGS3"/>
    <dbReference type="EnsemblFungi" id="CEF77646">
        <property type="protein sequence ID" value="CEF77646"/>
        <property type="gene ID" value="FGRRES_02948"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02948"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11685"/>
    <dbReference type="eggNOG" id="ENOG502SMNP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045148_3_1_1"/>
    <dbReference type="InParanoid" id="I1RGS3"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="2">
        <location>
            <begin position="27"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF77646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="365" mass="41652" checksum="590997EEE2E997EC" modified="2012-06-13" version="1">MMLPHRDKWDVHHAQIDELVYIGRDVFVMVASTLALYNAIELLTLIYLTFKRKSGLYFWSILIASFGLIPYCLGWLIVYFDLTHDYVGMIIETVGWVLVISGQSVVLYSRLHLITSERIILRSVLAVIIVNGLVWHTTMTVLLFGSEYSPKDNRNGFNNVFNIAEKISMSCFYMQELTISGIYIWKSLDIFKTAFGSTRTMLYKLFAINIAIVIMDIAMVVIELMNFYVWEQGIKLVTYSIKLKLEFAVLSELIEFVRSRSGTQSRPTKPSQNQSTFVPLSAVRRSSTKPTGFTGDRIYSGDTQTNITIAATHPAQETMTGDRIHVVRQVDVESLNACPYAERSTEELFEYMPDELPPELMPRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1RHQ1</accession>
    <name>I1RHQ1_GIBZE</name>
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        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG03312.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T12575</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322428.1">
        <property type="nucleotide sequence ID" value="XM_011324126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RHQ1"/>
    <dbReference type="EnsemblFungi" id="CEF78090">
        <property type="protein sequence ID" value="CEF78090"/>
        <property type="gene ID" value="FGRRES_03312"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03312"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12575"/>
    <dbReference type="eggNOG" id="KOG3017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035730_5_2_1"/>
    <dbReference type="InParanoid" id="I1RHQ1"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="PHI-base" id="PHI:7651"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124178" evidence="2">
        <location>
            <begin position="18"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="111"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF78090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="246" mass="26533" checksum="1E32240F0BBC3E96" modified="2012-06-13" version="1">MHFSAFLASVMATSAMASPHYKVVTEYAYVTKVVTAGAEQPKPTYVVEQPAPVEAKPTTLRWVKKPRQSHIPAPQPTYVPSPAPVEDEEPETKQPEKKEPDSGSSNGSLTADQQKAVDLHNEARKAVGNGPLEWDDSLVSGAQEWADHIASLGSLTHSQGKDGENLYMGTSSTPFADAIEAFLSEKSLYNGETISGSNYMSFGHYTQCVWKTTTKVGMAVAKGSDGASYVVARYQEPGNMIGSKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1RIB5</accession>
    <name>I1RIB5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG03546.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T13131</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322162.1">
        <property type="nucleotide sequence ID" value="XM_011323860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RIB5"/>
    <dbReference type="STRING" id="229533.I1RIB5"/>
    <dbReference type="EnsemblFungi" id="CEF78369">
        <property type="protein sequence ID" value="CEF78369"/>
        <property type="gene ID" value="FGRRES_03546"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03546"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13131"/>
    <dbReference type="eggNOG" id="KOG2304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_1"/>
    <dbReference type="InParanoid" id="I1RIB5"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF3">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="5">
        <location>
            <begin position="14"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="4">
        <location>
            <begin position="188"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="3">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF78369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="284" mass="31998" checksum="7B33F474E9F32C7F" modified="2012-06-13" version="1">MGSFTLPSTDGRIVSVLGGGVLGRRIACGWAASGYDVVIRDPSREQRVAALEYCNTSMPEYSDSKVRGSIKAVEDLPGAVEKAWLVIEAVPEQLPIKIATFADLERLTPEDAILCSNSSSYKSREMVGDLRPETKRRVLNMHYYIPPEYRVVELMTDGETDESIFPFLYMKLEEIKFHPYVARKESTGFIYNRLWAAIKREVLNILAEGVSTPEEIERLWKEMWYAKEMGPVTMMDAVGLDTVSFIEQHYISERGLPNTPVEFLQKYIDEGKLGAKSDKGGLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJ84</accession>
    <name>I1RJ84_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG03892.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T13975</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321776.1">
        <property type="nucleotide sequence ID" value="XM_011323474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJ84"/>
    <dbReference type="STRING" id="229533.I1RJ84"/>
    <dbReference type="EnsemblFungi" id="CEF78790">
        <property type="protein sequence ID" value="CEF78790"/>
        <property type="gene ID" value="FGRRES_03892"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03892"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13975"/>
    <dbReference type="eggNOG" id="ENOG502RXSB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016574_6_0_1"/>
    <dbReference type="InParanoid" id="I1RJ84"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="PHI-base" id="PHI:1882"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF78790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="436" mass="49023" checksum="23722102A0B89CF9" modified="2012-06-13" version="1">MSAPSTPGSSQRPYKVRQACDPCHRRKIRCNGSNPCVNCQNSGLGLESPIPIPDTGDFYPSPQITESVVKWCLDAYFKHKYPLTPILDRRKLEESPASAENYSLISACCAIIALSPEILPPSPTQDDITLPSADFLISETLRSRRHCKAVEHPSLIHVHTSFFLYAAFFSMDKDNQAWYYLQEAITMLQTLRLHEEITYDDFLDPIVSIYARRTFWVLFITERAYGLQRNRPIRLQETLELPAIDPLSQDADILLGFHDLISLFRPFDSDFITNWNQMTPSTPTDSVRLSHLQGLLKYSLPNLSNHSQVQQADLLISRQWLKTVVWKLCASKQILSTASSDNAMSLHYPASIARDIVLISQLVPTQAFEANGIGILEKVFDVGCSLADLMLLVPPDFQASAMDVGAIDTLVEMIGFKVGQSALTYTRKSYAMNDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJB3</accession>
    <accession>A0A098DIQ9</accession>
    <name>I1RJB3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG03923.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T14043</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321745.1">
        <property type="nucleotide sequence ID" value="XM_011323443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJB3"/>
    <dbReference type="STRING" id="229533.I1RJB3"/>
    <dbReference type="EnsemblFungi" id="CEF78824">
        <property type="protein sequence ID" value="CEF78824"/>
        <property type="gene ID" value="FGRRES_03923"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03923"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14043"/>
    <dbReference type="eggNOG" id="ENOG502SJR0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_6_1"/>
    <dbReference type="InParanoid" id="I1RJB3"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF31">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="8"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF78824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="325" mass="37028" checksum="F52C28BE391C3AED" modified="2012-06-13" version="1">MAQGAPQRKRVVIIGATGLQGGSVARILAQSPDRYIIRGLTRNTSSPKAQELFKLGIEVQQADLDDSKSLQEAFHDAHVIFAMTDFWQHMSAEREEAQGKSIMDIAAELPHLEQLIWADLPDANKISEGFYPHVYHWQSKAAVSKYIREEKPELWRKTTAVLFPNYFENCLTQPATYLPIKQADGTYLRSFVLPETANLPNVVISDTGKLVQYILDHPDQCLEKTIAFYSEAISEGEKIRSMAKAYNIDIRYHEMSSDEFQGILKKHMGDVTALDFTEQLLIFRDFGMIYERPEFVQANQLPGLKLTTWKEFMEANDLHSYMTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJN5</accession>
    <name>I1RJN5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG04062.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T14375</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321585.1">
        <property type="nucleotide sequence ID" value="XM_011323283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJN5"/>
    <dbReference type="EnsemblFungi" id="CEF78990">
        <property type="protein sequence ID" value="CEF78990"/>
        <property type="gene ID" value="FGRRES_04062"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04062"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14375"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="InParanoid" id="I1RJN5"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="13"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="487"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="490"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF78990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="516" mass="56621" checksum="C693C828B9EFEEE6" modified="2012-06-13" version="1">MTILVGKPLDWAITATAGSGFLLFGYDQGVMSGLLTGTAFTNTFPEIDTTEGGNGSSSLQGTVVAIYEIGCFFGAIFCLAFGEYFGRRNCILMGCVVLSIGAALQASAFGIPQMIVGRIVAGLGNGMNTSTIPVWHSELMKASNRGKGLAIELAINIFGVMLSYWVDYGMSFVSSDAQFRFPLAFQIFFAILTFIGILLLPESPRWLINHDRHEEAREVLWAVRKNAKSISKDDESVSRAIAEIQHAINEEREAAKTSSFKAMWKNGEQKFLYRTMLGIGGQFMQQLSGINLITYYAPVIFQESVGISHNLSLLLAGFNGVAYFFSSLIPIWIIDRLGRRKLMMFAAAGQAVCMAVLAGTVSTGQPGPGIVAIVMLFLFNFFFAVGLLAIPWLLPAEYAPLAIRTRAAALATASNWIFTFLVVEITPVSISSIGWKTYVYFCIFNACFVPLIYFFYPETRLLSLEQIDKLFTGPKILLHWDHSMGVPGEASEKSTDGETGKAIHDEKTEAEVHMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJN8</accession>
    <name>I1RJN8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG04066.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T14385</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321580.1">
        <property type="nucleotide sequence ID" value="XM_011323278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJN8"/>
    <dbReference type="EnsemblFungi" id="CEF78995">
        <property type="protein sequence ID" value="CEF78995"/>
        <property type="gene ID" value="FGRRES_04066"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04066"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14385"/>
    <dbReference type="HOGENOM" id="CLU_1115804_0_0_1"/>
    <dbReference type="InParanoid" id="I1RJN8"/>
    <dbReference type="OrthoDB" id="5064335at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF78995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="249" mass="27598" checksum="5C24A21E6113FE21" modified="2012-06-13" version="1">MDISNGVELSDSELGVSVFQTQNSDIVPQQESQEHTTPELENTSSYNPVDGENDIPSDEEDEFVIVETQMVEAAVEFAAASQAAQRSQHSHRNNNFSKDSQLLVFDDTEMMDIPEDRDPEQAYFEQNAKLDRKNLSGYDIPIGPFESEEYQQNTRVDKKVSLLRKIPGVKTAEQVFSASKRLAQSGIGNVTESIMSLAPRTREAAVATRQVGQYVAGSVLNAGQDVTIRVQESWWAWPRGVNGGVQNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I1RK24</accession>
    <name>I1RK24_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG04212.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T14747</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321414.1">
        <property type="nucleotide sequence ID" value="XM_011323112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RK24"/>
    <dbReference type="STRING" id="229533.I1RK24"/>
    <dbReference type="EnsemblFungi" id="CEF79175">
        <property type="protein sequence ID" value="CEF79175"/>
        <property type="gene ID" value="FGRRES_04212"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04212"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14747"/>
    <dbReference type="eggNOG" id="KOG0406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_9_1_1"/>
    <dbReference type="InParanoid" id="I1RK24"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005442">
        <property type="entry name" value="GST_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF13">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE OMEGA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01625">
        <property type="entry name" value="GSTRNSFRASEO"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="38"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="133"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF79175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="291" mass="33658" checksum="7AFBBB5833081C51" modified="2012-06-13" version="1">MQFTNYSRPTAMTNVDTSLPPEPTGAAANFAAQHSEEHPLKLYGGWFCPFVQRSWITIHEKRIPHQYVEINPYKKEPHFLALNPRGLVPTLAVPFDVQGKEQKALFESNIVCEYLDEAFFDESKHGPRLLPTEPYEKARCRIWIDHISTRIIPAWYKLMQHTPDKAFSLEDAREELKGHIKSFVEEMDSEGPWFLGSTLSLVDICFAPWAKRLFLIDYYKEGGHGIPTTGEGEDGDVWNRWNKWYKAILKRDSVNETWSADERYIIAYKRYAEDTTNSEVGQATRSGKRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>I1RKX3</accession>
    <name>I1RKX3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FGRAMPH1_01T15551</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321043.1">
        <property type="nucleotide sequence ID" value="XM_011322741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RKX3"/>
    <dbReference type="KEGG" id="fgr:FGSG_04544"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15551"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="InParanoid" id="I1RKX3"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="54"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SCB65974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="536" mass="59272" checksum="1E1464126FF325BE" modified="2012-06-13" version="1">MASLDKEANRDNHEVADLKRSELLEIDATRDLTVEEHNLGFREATRQYPWAVFWALFFGIAVIMAGFDAQIITSFYALPAFQTKYGEKVHGGDGYEVPAPWQTALGMGNPIGQILGALASGYPLEMFGRKKTLAFCCVWSIALVFVQFFSTSIGMLCAGEILGGLAYGFYVVIAPTYASEVCPLALRGFLTTSINMAFVIGQFIAQGCAAGVETRMDEWAYKIPFAIQWVWPAILLAGLPFAPESPYWLVRKGRREAARSALLGLSSSTNRPDIDKALVGIEQTDLLEQEIESSTSWMECFKRANLVRTEISVMVYLIQVIGGNPLIGYATYFFQKAGLDPSDAFNMGVGNTALGFTGTVLSWFLLNWFKLGRRTIYNAGMTVMTTLLFIIGFISISSTTSAAIWATATLMDIWTFVYQMTVGPICFVIISEISATRLREKTIAVATAVQAAASVVFTIVMPLMLNTDEANWGSKTAFLFGGISLVCLVWCYFRLPESQGRTFEELDILFQRRVPARQFKHFDLLNGVDNTVSREG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-12-02" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1RL18</accession>
    <accession>A0A098DNU6</accession>
    <name>DPFGI_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">O-methyltransferase dpfgI</fullName>
            <ecNumber evidence="3">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Diterpenoid pyrone biosynthesis cluster protein I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dpfgI</name>
        <name type="ORF">FG04596</name>
        <name type="ORF">FGRAMPH1_01T15663</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2020" name="Nat. Commun." volume="11" first="1830" last="1830">
            <title>Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones.</title>
            <authorList>
                <person name="Tsukada K."/>
                <person name="Shinki S."/>
                <person name="Kaneko A."/>
                <person name="Murakami K."/>
                <person name="Irie K."/>
                <person name="Murai M."/>
                <person name="Miyoshi H."/>
                <person name="Dan S."/>
                <person name="Kawaji K."/>
                <person name="Hayashi H."/>
                <person name="Kodama E.N."/>
                <person name="Hori A."/>
                <person name="Salim E."/>
                <person name="Kuraishi T."/>
                <person name="Hirata N."/>
                <person name="Kanda Y."/>
                <person name="Asai T."/>
            </authorList>
            <dbReference type="PubMed" id="32286350"/>
            <dbReference type="DOI" id="10.1038/s41467-020-15664-4"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <comment type="function">
        <text evidence="3 6">O-methyltransferase; part of the gene cluster that mediates the biosynthesis of diterpenoid pyrones (PubMed:32286350). The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpfgA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable). The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpfgD through the action of the prenyltransferase dpfgC to yield a linear alpha-pyrone diterpenoid (Probable). Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpfgE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpfgB (Probable). The short chain dehydrogenase/reductase dpfgG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpfgH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350). Higginsianin B is further methylated by the methyltransferase dpfgI to produce the intermediate named FDDP B (PubMed:32286350). The cytochrome P450 monooxygenase dfgpJ then catalyzes a three-step oxidation at C-27 to generate a carboxylic acid as well as C-26 hydroxylation (PubMed:32286350). Finally, methyltransferase dpfgK methylates the carboxylic acid generated by dpfgJ, yielding the final diterpenoid pyrones from the pathway which were named FDDP D and FDDP E (PubMed:32286350).</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="biotechnology">
        <text evidence="3">Diterpenoid pyrones display various biological activities and FDDP E shows anti-HIV activity (PubMed:32286350). FDDP D and FDDP E show also inhibitory activity of 42-mer-amyloid beta aggregation that is involved in the pathogenesis of Alzheimer's disease (PubMed:32286350).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320984.1">
        <property type="nucleotide sequence ID" value="XM_011322682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RL18"/>
    <dbReference type="SMR" id="I1RL18"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T15663">
        <property type="protein sequence ID" value="FGRAMPH1_01T15663-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G15663"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04596"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15663"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_5_0_1"/>
    <dbReference type="InParanoid" id="I1RL18"/>
    <dbReference type="OrthoDB" id="3340390at2759"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF4">
        <property type="entry name" value="O-METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000451554" description="O-methyltransferase dpfgI">
        <location>
            <begin position="1"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="232"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="279"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O04385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="32286350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="32286350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="32286350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF79631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="378" mass="42361" checksum="673A85B13CA59958" modified="2012-06-13" version="1">MAQQAPTMQIDNLLAQVKVLGSSLNVADRAKVQKSLLDALSHVETPYEHMLRLSGSLACIRFGADIGLFKALVESQEPLTCSYLGEKLNANANILGRILRLLASARLVKQTGLDTFTAEKITQELAAQAMESGAHLLFDIHNRTYQALPDYLCENKSKDVDNMHNGIFQKAFSTDLSCYEYLVHNPKLQGFMQDAMKLNQTEGDWLSVLPMEDEIKRWQASDPDRVLFVDIGGGMGHQCIRLRGKYSDIPGRVVLQDMPITVERIPKPMPHGIEAMPYNFEEPQPIKNAKFYYTRNVLHGLTDSASIAALKNVAAAMGTESLLVIDDLIIPDEGACTQACQLDFVMMASIAGKKRTRDQWEDKRKYNEYKCKRNSQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1RLD0</accession>
    <accession>A0A098E0A1</accession>
    <name>I1RLD0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG04723.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T16167</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323163.1">
        <property type="nucleotide sequence ID" value="XM_011324861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RLD0"/>
    <dbReference type="FunCoup" id="I1RLD0">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF87039">
        <property type="protein sequence ID" value="CEF87039"/>
        <property type="gene ID" value="FGRRES_04723"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04723"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16167"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="InParanoid" id="I1RLD0"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF40">
        <property type="entry name" value="THIAMINE PATHWAY TRANSPORTER THI73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="43"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF87039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="486" mass="52715" checksum="905FA5E4DDE37BF7" modified="2012-06-13" version="1">MAPSDMEKTQSNTRPASVAKGSVTDIAGEASLKPITRKVDYHLVPLMLVCYFLQFLDKVLINYANIMGLSETLNFKGNDFSWMATAFFIGFAVAEFPQGVLIQKFPVSKVLGINVVLWGTVICCSAAAVNFPGMTAARTLLGMFEAVISPSLIMITSQWYTRKQATPRTGIWYCGLGIGQTVGGLISYAAQHGSRTGSFQGWRIMFVSVGLFNVLVGLVVIFWMPSSIKDAKFLTEHEQLVLQEALAADQGGHCAKVFRPSGIWDALKDLQVWLLFLNTILIVIPSGIITTFSATLIRGFGYDSKQAALLNMPAGVVSVSATLLSTFAILYGFQRWLGLCLLMVPTLIGAGLMSFNSSSQASSLVGIYLINFDVAPLALIYALVGANIQGYTKKVTTNAIIAVGFSIANIIGPQTFQAKDAPSFLPAKVTVFCVCGGSVVVTILTRILYGVRNRKGRVSRDIGELDEVETMETMTDRDNPNFVYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I1RLN4</accession>
    <accession>A0A098DYJ4</accession>
    <name>I1RLN4_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arsenite methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG04845.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T16463</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>arsenic triglutathione + 2 [thioredoxin]-dithiol + 2 S-adenosyl-L-methionine + H2O = dimethylarsinous acid + 2 [thioredoxin]-disulfide + 3 glutathione + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:23808"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69432"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27130"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>arsenic triglutathione + [thioredoxin]-dithiol + S-adenosyl-L-methionine + 2 H2O = methylarsonous acid + [thioredoxin]-disulfide + 3 glutathione + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17826"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.137" evidence="4"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF85963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323304.1">
        <property type="nucleotide sequence ID" value="XM_011325002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RLN4"/>
    <dbReference type="EnsemblFungi" id="CEF85963">
        <property type="protein sequence ID" value="CEF85963"/>
        <property type="gene ID" value="FGRRES_04845"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04845"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16463"/>
    <dbReference type="eggNOG" id="ENOG502QQD6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052868_3_1_1"/>
    <dbReference type="InParanoid" id="I1RLN4"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030791">
        <property type="term" value="F:arsenite methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="ARSENITE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675:SF8">
        <property type="entry name" value="ARSENITE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="9">
        <location>
            <begin position="63"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF85963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="299" mass="31676" checksum="4EE4D3591191B68A" modified="2012-06-13" version="1">MDSKEIYEQVHKRYGSVTKSTTGKYEQTVAKAFGYTEEELAGIPEDANLGLSCGNPTALAKLREGETVIDLGSGAGFDVLTAAKKVGPAGKAIGVDMNKNMIDKANANKAAMKISNAGFIQGVITSVPLSDDAADCIISNCVINLVPASEKQLVFNEMFRILTPGGRVAISDILARKEFTDEIRNNIALYVGCIAGASPVGDYETFLKNAGFQGELNILIVDTKSDLNVYFTAQENESSCCGNEQTNPACGAGLSTCAPQNSSTELADGQDILGNRLGIADFNEWAGSFQVYAVKPMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1RMN2</accession>
    <name>I1RMN2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG05225.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T17409</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323736.1">
        <property type="nucleotide sequence ID" value="XM_011325434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RMN2"/>
    <dbReference type="STRING" id="229533.I1RMN2"/>
    <dbReference type="EnsemblFungi" id="CEF88430">
        <property type="protein sequence ID" value="CEF88430"/>
        <property type="gene ID" value="FGRRES_05225"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05225"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17409"/>
    <dbReference type="eggNOG" id="ENOG502RP9B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035068_0_0_1"/>
    <dbReference type="InParanoid" id="I1RMN2"/>
    <dbReference type="OrthoDB" id="5221663at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF88430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="334" mass="38198" checksum="803E7C93803C9395" modified="2012-06-13" version="1">MSSLDTVGSLLAAIANLLAQGLRILSLADKSHWGPDEYEQVHALASALDEAKKDFQELAPLVNGQIYYETDRKHESLEELRALKTQFTSHIEQIKDWSRSGGPINPVWIRETQTLQRKLHRAQCRAARRIYTSEKESSSRCLGAFLVYRQQRKWAMDKTVPDELEYSRRYREELRLCNAIGSFKRFGDRDIAFVCDYCDGHIIWEDIENMPSIRTFQEAAASPILTLSPTPDNPHWQATGFTKSGHQEKQMVFAPVAIANHVAPQHRDWLAGLLCPYCETESTVPQEQYDDEDAYRPDLGYEDMDAYQEHLEWQHTVTAPTSQAQASSDNCTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1RMS5</accession>
    <name>I1RMS5_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG05272.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T17505</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323783.1">
        <property type="nucleotide sequence ID" value="XM_011325481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RMS5"/>
    <dbReference type="STRING" id="229533.I1RMS5"/>
    <dbReference type="EnsemblFungi" id="CEF87056">
        <property type="protein sequence ID" value="CEF87056"/>
        <property type="gene ID" value="FGRRES_05272"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05272"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17505"/>
    <dbReference type="eggNOG" id="KOG0029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_0_3_1"/>
    <dbReference type="InParanoid" id="I1RMS5"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF14">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="41"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF87056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="471" mass="51142" checksum="5C5BBF6617E2630D" modified="2012-06-13" version="1">MTLTNSKKPETIDVVVVGAGLSGLRAAVKIHEAGYSVIVLEAGDRVGGKTLSVNASHLGGKVDLGAAWINDTNQSEMYKLAQEFGFDLIKQRATGLNLHQQLDGKVDKIPHGDGMPLPSGATELVQEFIEKLNRWVEEIDPENPSDHPEAKMLDSLTFGQLGAKHLGPELGPAVADSATSPLLGVGPDEVSALFMIDYFRSGTGVANMASDGKDGGQYLRNRQGNQAFSIRLAAKLPKAAVRLLSPVKTIIQGSDGVIVETANPGQKFRAKRVVVSVPTCLYSSLAFEPPLPLTKKTLSDSTALGYYSKTIFVFDKPWWREAGLSGIIESDAGPIYFSRDTCSEEDGQYSITCFIVGDRGREWSKWSSAEQKRIVSDQFNRIFSAVGIEAPDPVNVIVHEWVKQPWIWGAPSPVMMPGLLTSDSGKALREFYGRIHFVGTETSLVWKGYMEGAVRSGVRGAKEVIKAFEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1RNK2</accession>
    <accession>A0A098DWA1</accession>
    <name>I1RNK2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG05585.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T18265</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324138.1">
        <property type="nucleotide sequence ID" value="XM_011325836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RNK2"/>
    <dbReference type="FunCoup" id="I1RNK2">
        <property type="interactions" value="618"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RNK2"/>
    <dbReference type="EnsemblFungi" id="CEF86106">
        <property type="protein sequence ID" value="CEF86106"/>
        <property type="gene ID" value="FGRRES_05585"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05585"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18265"/>
    <dbReference type="eggNOG" id="KOG0294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030368_0_0_1"/>
    <dbReference type="InParanoid" id="I1RNK2"/>
    <dbReference type="OrthoDB" id="308449at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF86106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="504" mass="54371" checksum="5C4AA4E41986DA55" modified="2012-06-13" version="1">MAKRKRQAVAQRAAYEPSVITKKVKGTKVLKEKPVKEKASAPAKKTTTTTTTTTTTTVTKTTSNVPETIQIVVGSYDRILHGLTVTVGGKEKAQFADTFLFNAHTSAIRCVAVSPISAPVPGQTQKVMLASGATDERVNVYNLSAHPPSRKNQELMAKVAPRPILENSKNREVGTLLHHSSTVTSLCFPTRSKLLSSSEDSTIAVTRTRDWSLLSNIKAPIAKPLGRPSGDTAPFGGTPSGVNDFAIHPSMKLMITVSKGERSMRLWNLVTGKKAGVLNFGKDILLEAGEGKHSTGEGRRVVWGNVDGADEFAVGFDRDVIAFGMDSVPKCRIMGSIRTKVHQFFYVALDKEGDATLLAVATEDGRILFFSTKDSDLTKTDSEDKKLPTAKLVGQLGGKSDGVQGRIKDFVVVPSAEDASTLYVAGGSSDGRVRVWRVGVSELQGNSKSEEVEAKGELLGTYETQNRITCMTGFMMIPRPDGVEDSEDELEDEDEDEGSDSEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>I1RPD3</accession>
    <name>I1RPD3_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG05898.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T19029</name>
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    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 6"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324505.1">
        <property type="nucleotide sequence ID" value="XM_011326203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RPD3"/>
    <dbReference type="FunCoup" id="I1RPD3">
        <property type="interactions" value="349"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RPD3"/>
    <dbReference type="EnsemblFungi" id="CEF88526">
        <property type="protein sequence ID" value="CEF88526"/>
        <property type="gene ID" value="FGRRES_05898"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05898"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19029"/>
    <dbReference type="eggNOG" id="KOG0169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002738_1_0_1"/>
    <dbReference type="InParanoid" id="I1RPD3"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="PHI-base" id="PHI:6719"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16207">
        <property type="entry name" value="EFh_ScPlc1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13360">
        <property type="entry name" value="PH_PLC_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037755">
        <property type="entry name" value="Plc1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="774"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="892"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="140"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="683"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1085"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="707"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1097"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF88526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1111" mass="125386" checksum="9200DEFF8BADE6F8" modified="2012-06-13" version="1">MSFNFVHDSKFTSPTHNLSEMSSLTRSQLGQVQTSFPSQTQPVPIPMSATSASTGTSNSQQGSPIMSPDTAVLTTYSSVQASPEPMRGREEEAFPSSFQLPESVLSRKTSTNSLGYNAMSEVANNSKGGLIRRFSNRAQRFAGRRRPSSGAPASRDGSVGPSILRRRSDSNATAPQENSALTDTDEEFVPDDSMSMVGVDGANYTSSANSTHGSISASAGAMAGPVLPAELRNGCPVKKVSKKSRPKRITLAYETESNKLSWDPSRPQKSLHVDEIREIRTGTDIQQYIHDYGLSEQIEFYFPVWFTIIYNVPESSKTRFLHIVTDNSNTLSLWTEFLDAMLRYRQQLMTSLMSFNDRAVAQYWQTEMAKEFGDQARTPDQEEMNIAGVKRVCQNLHIYSSSSTLEVNFHLSDSRRRSKLNFREFKDFVRRMKQRNDVQRVIRNIAANPEFGLTLSEFLTFLRDDQGEDVDSNRTAWEKLFSRFCRQYRSTEADLPENVEIMTEAAFVAFLTSEDNEVIQPEPQNIVLDRPMNEYYISSSHNTYLLGRQVAGQSSVEGYISALARGCRCVEVDCWDGYNGQPEVNHGRTMTTSISFKEVMTTINKYAFVKSKFPLWISLEVHCSPAQQATMVEIIKESFGSRLVTETLEAFPDKLPTPSELMERVLIKVKKPQIKEEPIAAGNDFRGRRRGNSLNSPMMRPSVPDGTPLMPSQSLPQSPMLTPSHSSRRLVSKTRVNTITEGQVQGMLSSSTSDNESVSEQPVKKVHNKTVKVLGDLGVYCAGVKFSGFDTVDAKQYNHIFSFMESSFAKHSRAKDQKMALDIHNMRYMMRVYPDRTRITSNNFDPLNYWRRGVQMAALNWQTFDLGMQLNRAMFDGKDSSGYVLKPAELRDIQVLPYNADIAEGKKERTVISFTIDVISAQQLMRPANLPANKSMDPYVEVEVFHANDKRDKKEADSNLVLEHDTPLKYQTDVIRENGFNPLFDRTMKYTVTTKHPDLIFVRWSVKLSNDGESYNERPAVATYTAKLTNLKQGYRTLPLLNHAGDQYLFSKLFCKIKIDSVEKKFMEAPRRVQDGNKLNRLGGKVFSRMNTSPKSTIEKSSSEKTSFDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQ82</accession>
    <name>I1RQ82_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial inner membrane protease subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG06221.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T19793</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324866.1">
        <property type="nucleotide sequence ID" value="XM_011326564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQ82"/>
    <dbReference type="FunCoup" id="I1RQ82">
        <property type="interactions" value="361"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RQ82"/>
    <dbReference type="EnsemblFungi" id="CEF86573">
        <property type="protein sequence ID" value="CEF86573"/>
        <property type="gene ID" value="FGRRES_06221"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06221"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19793"/>
    <dbReference type="eggNOG" id="KOG1568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_4_1_1"/>
    <dbReference type="InParanoid" id="I1RQ82"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="active site" evidence="11">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF86573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="183" mass="20376" checksum="9051325BA53F6E13" modified="2012-06-13" version="1">MALGSIWARLRGNGQASLARSTALRVFGFATWIPVIAMFNLHVAELTFVDGASMYPLINDEKDSTLQRDVILNWKWSPQENLERGMVVTLRSPLHPETIAVKRVVALENDVIKTKAPHPLPTVRVPQGHVWVEGDGPPGSSLDSNTYGPVSKQLITGRVTHVVFPFRKCGALPWREHKRPLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQR1</accession>
    <name>I1RQR1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG06409.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T20233</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gemin-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325073.1">
        <property type="nucleotide sequence ID" value="XM_011326771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQR1"/>
    <dbReference type="EnsemblFungi" id="CEF87824">
        <property type="protein sequence ID" value="CEF87824"/>
        <property type="gene ID" value="FGRRES_06409"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06409"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20233"/>
    <dbReference type="eggNOG" id="ENOG502SCAA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022029_1_0_1"/>
    <dbReference type="InParanoid" id="I1RQR1"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794:SF0">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794">
        <property type="entry name" value="GEMIN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF87824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="485" mass="53826" checksum="D701209FED0521C7" modified="2012-06-13" version="1">MATKREFKDVDEGDTLKPKPKRSKKHGGKARQHQNSGIDPTWGQKYVFADNEHATTIPAGEESDFEDDADAMAYLNSVRQQAAGIPHLLVAPKVQIGPQLPAELRGDDQDDGEGPIDRNIYSDGVGDSRGWYEDGAYMAMPDNVDDEGNYKGEYSEDDDDDFDEEVAIHEAYFASVMDQYHHLRTILHASPPQNARSRLAKAQLKTEAPADNQTSVIATWSRLLRDTDPHPLQIAHMSKDTTLRILRIMLGGKFLRRGYTLPERTSRWIWALLARLPDKGELNYAEIGWIRDLGRRAVLLGRSLSEMAALREELAEGGLGAHEAVDRSSSDEDIMADPEDLEIEGAVSAEEDEEASTPPEAEQKAEQPPEAAEPTTTSPPKPDTEEGEIDEEEDVAMDTASDSDAEEGEVAAPEPEESLKAAKERLLAQINYRAASEDDEEAVKEAAKQRLRANLRATLNMILTIAGEFYGQRDLLEFREPFVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1RR39</accession>
    <name>I1RR39_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG06548.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T22559</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326159.1">
        <property type="nucleotide sequence ID" value="XM_011327857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RR39"/>
    <dbReference type="STRING" id="229533.I1RR39"/>
    <dbReference type="EnsemblFungi" id="CEF83684">
        <property type="protein sequence ID" value="CEF83684"/>
        <property type="gene ID" value="FGRRES_06548"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06548"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22559"/>
    <dbReference type="eggNOG" id="ENOG502QQVE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_0_1_1"/>
    <dbReference type="InParanoid" id="I1RR39"/>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43491">
        <property type="entry name" value="UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43491:SF2">
        <property type="entry name" value="UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase N-terminal" evidence="4">
        <location>
            <begin position="65"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase dimerisation" evidence="3">
        <location>
            <begin position="243"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF83684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="450" mass="49301" checksum="6F88304CFCF74AD2" modified="2012-06-13" version="1">MTQVLSKSLLIQGLPFVSHQTDTKSWNFSSREYYDITPPSEVSETEDAFQDVVTHSIDTNAEPLVAVIGVGYVGEHLVDVFSRNHDVLGYDVSEARTLQLAKKQAVGSRARFTSKASDLAKATHFLISVPTLLLDNKTIDSSFLQSAINVVRLYGRQGAVVVVESSVAVGMTRALLGSLAKERGFYAGMSPERVDPGRVEPPAHSIPKIVSGLDDIVPGSLDAIIRLYSKSFDNVVPVSKPEVAEMMKLYENCQRMVCIAYANEMADACGPHGIDPYEVCRAASTKPFGYLPFSPGLGVGGHCIPVNPWYLLSNSEFPFLRTAAEKMHARPSEIAQRAVSRLCNSDNNGLKPRVLVVGIGFKRGQSHLANSPGLELAKKLVETNKVDVAWADPLVAQEAVPQIERLPESDWTVEALERDFDMVIVAFRQDGLDFDVLDQVQGVLVERWCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1RRA5</accession>
    <name>I1RRA5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG06622.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T22753</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF82777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326241.1">
        <property type="nucleotide sequence ID" value="XM_011327939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RRA5"/>
    <dbReference type="STRING" id="229533.I1RRA5"/>
    <dbReference type="EnsemblFungi" id="CEF82777">
        <property type="protein sequence ID" value="CEF82777"/>
        <property type="gene ID" value="FGRRES_06622"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06622"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22753"/>
    <dbReference type="eggNOG" id="ENOG502QPR8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061063_0_0_1"/>
    <dbReference type="InParanoid" id="I1RRA5"/>
    <dbReference type="OrthoDB" id="2111841at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047793">
        <property type="term" value="F:cycloeucalenol cycloisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020532">
        <property type="entry name" value="Cycloeucalenol_cycloisomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35136">
        <property type="entry name" value="CYCLOEUCALENOL CYCLOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35136:SF1">
        <property type="entry name" value="CYCLOEUCALENOL CYCLOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF82777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF82777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="269" mass="30563" checksum="DEA9E8FE363D051F" modified="2012-06-13" version="1">MAPPSTPSIYKATAQSIEAEKRWTQRLNLFLSPFWIVAVAFAMLSGIMHSWNDIDYLLFSIAVATPPALFPALLSKKIGRPWYRRYWFKLNVWVAVIVCLGTYFTSHYFFDLMGMRYKFPCKWNFSSAVVGRTGGQVPVFLYPLTHAYFMTYYTVLMVTEKAVVQVLQPGRFGRAVVVVALSYGVALGETFFMASPLLSDWFYYEKTDRMMTVGSLGYMAFFITGLPMVGRIDAKGEDWPLSRVVIEALGTFMSILVLFEVWAKVVGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1RRM6</accession>
    <name>I1RRM6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG06758.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T23111</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326405.1">
        <property type="nucleotide sequence ID" value="XM_011328103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RRM6"/>
    <dbReference type="EnsemblFungi" id="CEF84103">
        <property type="protein sequence ID" value="CEF84103"/>
        <property type="gene ID" value="FGRRES_06758"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06758"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23111"/>
    <dbReference type="eggNOG" id="KOG2733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031002_0_1_1"/>
    <dbReference type="InParanoid" id="I1RRM6"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000592">
        <property type="entry name" value="Similar to saccharopine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="12"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF84103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="421" mass="46027" checksum="37FFC81C53721359" modified="2012-06-13" version="1">MALKDHGRQYDIVIFGATGYTGKLTAEYIATHLPTDLKWAVAGRNESKLDALVEDCKKRNSDRLQPAIEIANLNDADLSALAKKTCVLLTTVGPYSLYGEHAYKACAEEGTHYVDVTGEAAWVHKMIKKYEATAKKTGAILIPQAGIESAPADLITWALAKTLRIELGSQTKDVTVSLHDVKSAPSGGTLATALNIWDVFTLKEMKDASSPYAQSPIPHKEPTRPKSTMLEMILGVRSVSNLGLLTTSIAGTTDVAVVERTWGLLSETPSRKEEFYGPNFVWQERMKARNWLHGIFIHWLLIIGGVLLVSVAPLREFLKKRVVQPGQGASSEDTAKDYVEYRGIAYPDSEKQATKAAFGRMWHHGGMYLLTAVLLSEIAATILEDNVELDGGSYTPACLGQGLIDRLDKSGLKLDVKTIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>I1RRV1</accession>
    <name>I1RRV1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG06843.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T23313</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
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    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326496.1">
        <property type="nucleotide sequence ID" value="XM_011328194.1"/>
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    <dbReference type="AlphaFoldDB" id="I1RRV1"/>
    <dbReference type="FunCoup" id="I1RRV1">
        <property type="interactions" value="1122"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RRV1"/>
    <dbReference type="EnsemblFungi" id="CEF83223">
        <property type="protein sequence ID" value="CEF83223"/>
        <property type="gene ID" value="FGRRES_06843"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06843"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23313"/>
    <dbReference type="eggNOG" id="KOG0466">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_027154_0_1_1"/>
    <dbReference type="InParanoid" id="I1RRV1"/>
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    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
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        <property type="term" value="C:multi-eIF complex"/>
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        <property type="term" value="C:ribosome"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:GTP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:methionyl-initiator methionine tRNA binding"/>
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        <property type="term" value="F:translation initiation factor activity"/>
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        <property type="term" value="P:formation of translation preinitiation complex"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045903">
        <property type="term" value="P:positive regulation of translational fidelity"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
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    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
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    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="79"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF83223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="509" mass="54732" checksum="2EB6808EAEBE95F0" modified="2012-06-13" version="1">MSTNDDPKYDDIGSESDSGESVGHNEAADEKPLKSALKKSNPAIAEPAAQRPPLPPQTEPKDLDVASLTPLTPEIIARQATINIGTIGHVAHGKSTVVKAISGVQTVRFKNELIRNITIKLGYANAKIYKCDNQACPRPGCYRSYKSDKEVDPPCERDGCGGTYRLLRHVSFVDCPGHDILMSTMLSGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLDKIIILQNKVDLMREEAAQQHYQSILKFIRGTVAGKSPVIPISAQLKFNIDAVNEAIVNTIPVPPRDFSIDPHMIVIRSFDVNKPGSEIDELKGGVAGGSILHGVIKLGDEIEIRPGIVARDDNGALKCTPIFSRVVSLNSEANDLKYAVPGGLIGVGTRIDPTLCRADRLVGFVLGLKGRLPEIYSEIEVNFYLLRRLLGVRTADGKQAKVAKLAKNEVIMVNIGSTSTGAKVAAIKNDAAKLVLTSPACTNIGEKVALSRRIEKHWRLIGWATIAAGVTLEPSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I1RSL0</accession>
    <accession>A0A098DNJ0</accession>
    <name>I1RSL0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG07133.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T24045</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326843.1">
        <property type="nucleotide sequence ID" value="XM_011328541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RSL0"/>
    <dbReference type="STRING" id="229533.I1RSL0"/>
    <dbReference type="EnsemblFungi" id="CEF83425">
        <property type="protein sequence ID" value="CEF83425"/>
        <property type="gene ID" value="FGRRES_07133"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07133"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24045"/>
    <dbReference type="eggNOG" id="ENOG502SAWI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011074_1_0_1"/>
    <dbReference type="InParanoid" id="I1RSL0"/>
    <dbReference type="OrthoDB" id="4150467at2759"/>
    <dbReference type="PHI-base" id="PHI:1915"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="554"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="616"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="484"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF83425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="639" mass="68420" checksum="7B526C9F22842B69" modified="2012-06-13" version="1">MASMSPLNTAFDPSGASSNGGSVSPQQTATPKNVAFELLFPESPQCRARLPMRVQIYPHDTTDSIVTTVKNFYGLYSGPTGSKGVSFEDRGGNTLIARYENFQDRMVVYVRVIEEPPANPSAYAPHPYHNPSVTNHPYYSDNGYPAPQASRCAQEMSRPSSPSSRRRSPSPHTARGRRSASASTNGKKGRSRSSKTRASASRSHNELYSDSITGYSSNDEHDSTSGKNKDQLPTTDISVENIVEGGRRKRAKFESSELPLFAPPQMPAATSNPSVSPARRVEPHRPAVPYVQPHQNPFTNPPRPMQSPQGYNNAMTNSKLYQTPAPDARRNRNSGGYTSSAMGVIPTPDPTVGSCVSEEDKDVAIQLMRLCDMSNISHGRTSASTVDDTFSGIADAASSTGATSDGDSDSEAELPPSRRQKLDNSGAVGKVYQTTESHFMPPPESAEVSGDDADYEDGADDSLHSNGKSKPAKTMKAPSKHKGSSSTSKASSNKASKAARPVNGSKGKKLPPVPSGPMSPASMPPSRKQSVASTGQTPLVPGEDDQPDLSTKPRCQRCRKSKKGCDRQRPCGRCRDAGLNADQCISEDEGNGRKGRYGRHMGVPIKKDEVPAVAQPALLPAAPIASAATTMDKSKKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1RU95</accession>
    <accession>A0A098DVS2</accession>
    <name>I1RU95_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG07780.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T25649</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327598.1">
        <property type="nucleotide sequence ID" value="XM_011329296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RU95"/>
    <dbReference type="STRING" id="229533.I1RU95"/>
    <dbReference type="EnsemblFungi" id="CEF84943">
        <property type="protein sequence ID" value="CEF84943"/>
        <property type="gene ID" value="FGRRES_07780"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07780"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25649"/>
    <dbReference type="eggNOG" id="ENOG502S0JD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_4_1"/>
    <dbReference type="InParanoid" id="I1RU95"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="7"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF84943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="305" mass="33635" checksum="A16836310F9A8BB9" modified="2012-06-13" version="1">MSTFNTQKTMLIFGATGKQGGAAIDNILSHSPDSAFHLIAVTRDATSRKARALATNLKISVVEGDLDNVGAIFAKAGPVWGVYSVQINSDAEEQQGKAVINAAVQHGVRHFVYSSGDRGGPERSPNNPTYVKNFAAKYAIEKHLEQQARESVQQMTYTILRPVTFFENITTDIHGKGFARMWEQMGSKKLQMVSTKDIGWFAAQSLIWPDMYRNKALTLVGDELTQQEADAIYRQVIGRGMALAPCPVASAVKFVLKGSVGDMFKWFADEGYGGDVKECLSYNPGMQDFRTWLEENKSDFEKNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1RUC6</accession>
    <accession>A0A098DNB2</accession>
    <name>I1RUC6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG07815.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T25739</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF82829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327640.1">
        <property type="nucleotide sequence ID" value="XM_011329338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RUC6"/>
    <dbReference type="STRING" id="229533.I1RUC6"/>
    <dbReference type="EnsemblFungi" id="CEF82829">
        <property type="protein sequence ID" value="CEF82829"/>
        <property type="gene ID" value="FGRRES_07815"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07815"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25739"/>
    <dbReference type="eggNOG" id="ENOG502QSAC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032323_1_0_1"/>
    <dbReference type="InParanoid" id="I1RUC6"/>
    <dbReference type="OrthoDB" id="2283785at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039634">
        <property type="entry name" value="Bul1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904:SF1">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="284"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF82829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF82829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="448" mass="50519" checksum="2450A2661E6B1E84" modified="2012-06-13" version="1">MEPPYTQRTGVPLQTRPVLSPLDPSALQSLNYILPPKKNGLTIHIQHHYASKRYRPGSIVMGTVIIKPKKQTPFTSISIKFVCDSSVERPNATLLFETWHRLLDLQMPIEQAILPANKVLQPNETYTVPFYFVLPTTLGTEACSHNVIWRETREMHSHLPPSVTGWESDAMIPRGVRVDYGVVAQVWDSANPEYAKMEAKETIQFLPGHIRHSHLKISTENRNFKFGSSKHLKSGVFGRSWGEITLCADQPTAIVLDSSGKSFHPTTVVTSLRLNLCNHETSLPQICSVSAKIESETWSQDEPMQQLPHIVNARDCYNSSETLLKKTEIGLSWEKDSPKQTDNVVTETRETFSSHIKIPITNFASNKKMFLPTFYSCLIARTYQLHLTVNVASATLKLVLPVQLTVEEQKGDVQPDAEDIGFPESSVRYSSSLPSYIESERRHSQPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RUI0</accession>
    <name>I1RUI0_GIBZE</name>
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        <submittedName>
            <fullName evidence="7">Chromosome 4, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="8" type="primary">FG07873.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T25873</name>
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    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327704.1">
        <property type="nucleotide sequence ID" value="XM_011329402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RUI0"/>
    <dbReference type="FunCoup" id="I1RUI0">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RUI0"/>
    <dbReference type="EnsemblFungi" id="CEF84947">
        <property type="protein sequence ID" value="CEF84947"/>
        <property type="gene ID" value="FGRRES_07873"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07873"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25873"/>
    <dbReference type="eggNOG" id="KOG4812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041193_0_0_1"/>
    <dbReference type="InParanoid" id="I1RUI0"/>
    <dbReference type="OrthoDB" id="10003116at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22212">
        <property type="entry name" value="NDFIP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019325">
        <property type="entry name" value="NEDD4/Bsd2"/>
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    <dbReference type="PANTHER" id="PTHR13396:SF5">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10176">
        <property type="entry name" value="NEDD4_Bsd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF84947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="330" mass="35729" checksum="90F05D7B42497F7C" modified="2012-06-13" version="1">MSGRYERVNAQDEEDFHNNNNNNNNNRISPVPHSPPPSFHSRAPSPQRQVDNTLADAFDDDDDSDDEVDDRQRLMRQNSTPSFDTTNATSTPAQPAVPAPTPSASRSTRVVGGGSGSDGVFANLSARPERGGNSDPEKDELPPSYEQAAADAAPPYWETTILAPGMGGPDEVYIDGMPVGSFFSFVWNGMISTSFQLVGFLLTYLLHSTHAAKNGSRAGLGITLIQYGFYMKGASEDEPPAMSGPDGYAAPPDPNSHNFKQGDVTDEDLGNITGSEWLGYVLMVVGWFLLIKSVAEFLRARRHEQLVLQSPDRGLSVPIIAEGESNERVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1RV95</accession>
    <accession>A0A098DDC3</accession>
    <name>I1RV95_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG08160.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T09255</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the secreted LysM effector family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320653.1">
        <property type="nucleotide sequence ID" value="XM_011322351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RV95"/>
    <dbReference type="STRING" id="229533.I1RV95"/>
    <dbReference type="EnsemblFungi" id="CEF76430">
        <property type="protein sequence ID" value="CEF76430"/>
        <property type="gene ID" value="FGRRES_08160"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08160"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09255"/>
    <dbReference type="eggNOG" id="ENOG502SK24">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010591_5_3_1"/>
    <dbReference type="InParanoid" id="I1RV95"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF16">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="164"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF76430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="403" mass="44709" checksum="E327F258D79F378B" modified="2012-06-13" version="1">MTLPFTVAPFLVLQVVAVTILALLANLPLAAERKSLRSWFNTVELACRGYTLGGAVPMLWAGYMWAGYNETCLKDSSGQYCNDVISKFTSVSDYTKMPREEMCSTCYVKRLAMMQASPYSIYDDYYERQLQYIYAKCGLKGNTTVPNSLTPELEDNSLDCGTDEWYTTSTGETYDSIGLKRGVSASLFIVNQYHLPSCSADAVIEPGTKLCMPAKCDRVHQLRTEEDYHLLESHATNKLLEGDVQLYNPWVGYNCINLQEFTAAYGNIICFGLEFEQNNTSYNSTDTTTPQPFNPYTYDKIAPPTGAKVPQGTTERCGRWYVAGKEDSCAHICAVSSIDIDLLFMVNTGLGTDAAACSAKLVAGNAYCVGPNHDWKDPYPQRTSVSTTIYITDGYVWPTKTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1RVU4</accession>
    <name>I1RVU4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG08389.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T09835</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
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        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
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        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        <citation type="submission" date="2017-01" db="UniProtKB">
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                <consortium name="EnsemblFungi"/>
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        </citation>
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            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
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            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="6 7" key="2">
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            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>PH-1</strain>
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        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
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    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
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        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        </source>
    </evidence>
    <sequence length="853" mass="91572" checksum="D22B6AE7F0AB93DF" modified="2012-06-13" version="1">MSQPYDGRGMDPYSGSTRRARERTQGGYSRHQPTYSDPMEDDPPGELRAPPPRRPMGANTMGQSRIPKSKHAVDRSGNSGLTISRPQQVPQWPLSGPPMAAMNQPEAEPYRPPPGKPTQAPRRPPRPSQVPSLLDQSRLQEPTPVFLTPEPEEYDSAVPPSPSSRNTISSLGSVPDFPEPSQVQAANRRSTYLGPPPSARRGVSSFYSHASFVSPIPEESLNSRSHDSYASSAAMPDSWRGGSPVGSPSYYDDGATDRSQDEDFHDESKLVRSASIGKRGKPSLVNTKSVIMEPSYRPAPSPVQPFDSGTGYIDASSSSSNTLPLGRTSATGQNPHDSLSPDAILGAFAAASATNLSESQAPAPSPSPQSYNRLSAIRRPPKLDIDAVRKAEERGSMTSLPDLIRRATRLATMIDHGKRPGSRFDNLNDFFDDKGQMRGGDKENSGLSDMLAAFPPPAQPTGRQSRGSWFRTTSWPLAPGPGQGNGPSRNGQRGGTPSDEGQGKPRRRCCGLPVWAFVMLMILLLCIIVAAVLVPLEFFVFKNLGNHDKPQSALAQCQQSLKCQNGGTNIMSQGTCSCICTNGFTGSDCSVAGSDGCTMTDFGGDLSNVTLGKNIPRLIEDSAKNFSIPLSGTAIMAKLNSQELSCIAQNSLVTFDGAASRKRGLMLDQDKREAHAASLVPRAPESATAIVVSSETANPTKLIVDEGSPEGVPTTTGSATKSSSTAVPTQTQTPTNKFQITNEVLDFARVAVLFVLQQQDLDSAQDTQSSIDKFFAKARKDDGVLVKEAENVSIGDKKSVDLLRYKITLGSSTVGGNVKRHTLFVKTTPAYVSVRHRAVHTWRQGRTEAIQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1RW64</accession>
    <accession>A0A098DEM2</accession>
    <name>I1RW64_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">enoyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">FG08521.1</name>
        <name evidence="14" type="ORF">FGRAMPH1_01T10165</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320239.1">
        <property type="nucleotide sequence ID" value="XM_011321937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RW64"/>
    <dbReference type="FunCoup" id="I1RW64">
        <property type="interactions" value="709"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RW64"/>
    <dbReference type="EnsemblFungi" id="CEF76885">
        <property type="protein sequence ID" value="CEF76885"/>
        <property type="gene ID" value="FGRRES_08521"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08521"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10165"/>
    <dbReference type="eggNOG" id="KOG0025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_17_0_1"/>
    <dbReference type="InParanoid" id="I1RW64"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000112">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="60"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CEF76885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="419" mass="45309" checksum="2680FEE794D32580" modified="2012-06-13" version="1">MASSQCLRLRPLASGLTRPSAKLSAQHMTRLPMTAARYKSGPYGYTQAKALVFSKPGEPSDVLSLHTHSISPSIPSNSVLVQALAAPINPADINTVQGTYGSKPPFTSLIGTSEPSAIPGNEGVFEVVSTGSPSSSLQKGDWVIPAIGQFGTWRTHAVDEADKFLKIDKEGLTPTQVATVSVNPSTAYRILRHYGPNAGLQAGLGMRPLEVGSGQWFIQNGANSGVGRAAIQFGKLWGLRSINVVRDRDTPEATETLRKELLDLGADVVVTESQFLSREWRDQLAEITRKGREEIGLGLNCVGGKSATALARSLGNGATLVSYGGMAKQPVQLPLGLLIFKDTRFTGFWLSRLNEQDPTGRKHAINDILQIIRSGQFRDVPIEEVKWDWDTEEETLRNAVQQGLQGFRKGKGVFTFGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1RX08</accession>
    <name>I1RX08_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG08849.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T10987</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319863.1">
        <property type="nucleotide sequence ID" value="XM_011321561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RX08"/>
    <dbReference type="FunCoup" id="I1RX08">
        <property type="interactions" value="274"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RX08"/>
    <dbReference type="EnsemblFungi" id="CEF77296">
        <property type="protein sequence ID" value="CEF77296"/>
        <property type="gene ID" value="FGRRES_08849"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08849"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10987"/>
    <dbReference type="eggNOG" id="KOG3089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057568_0_1_1"/>
    <dbReference type="InParanoid" id="I1RX08"/>
    <dbReference type="OrthoDB" id="1929311at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF77296.1"/>
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    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF77296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="248" mass="28022" checksum="BF9E72005D65496F" modified="2012-06-13" version="1">MSTTKKRQAEDTPTQPKPKKSKKRKAGAPDDELLNTELGLNTLFTKMDNQLLADHLAQKLTRFGSDLSAIEISDMTLSANTIQDTTTWQEPRTLDKFPNFLESVTENPELLYKSAKKKGSPHTLIVTGAGLRAADIVRSMRKFQNKDNAIAKLFAKHFKIEEQVKFLGEHRTGISVGTPARLMDLMDNGALSLDGLKRLVVDASHIDQKKRGVLDMKDTMMPLARFLSRKEFKDRYDDEKKPLALLFY</sequence>
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    <accession>I1RY28</accession>
    <accession>A0A098DR62</accession>
    <name>I1RY28_GIBZE</name>
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            <fullName evidence="2">Chromosome 4, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328510.1">
        <property type="nucleotide sequence ID" value="XM_011330208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RY28"/>
    <dbReference type="STRING" id="229533.I1RY28"/>
    <dbReference type="EnsemblFungi" id="CEF84331">
        <property type="protein sequence ID" value="CEF84331"/>
        <property type="gene ID" value="FGRRES_09258"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09258"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27535"/>
    <dbReference type="eggNOG" id="ENOG502RJFE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052531_0_0_1"/>
    <dbReference type="InParanoid" id="I1RY28"/>
    <dbReference type="OrthoDB" id="5232891at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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    </feature>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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    <sequence length="427" mass="47750" checksum="4D88CBE67084EA9A" modified="2012-06-13" version="1">MENSLAKTNSLKPPRRKLQKADPKLKSLNKAKRGSTDSHSSSTMASLSPMSSPTQHQMSNGAPDLSDSKWDHYLRPKTVFVPSFSEAEEQHSEENMNQYYHHQPVQHPEPSPRAACFSPPPQGQSSFHRQIPEFHHLTLHEHRARPSLDRSSLPSTASTTSTSSAMRRQAKTPVFRIGQLEQHALARKAKDVQEKTSSVELIADQYHALLETRDGPPALDSQLPSRASSQYSFDDTPLQIPPYAAKRSQSMRTAKTSSSMTAIPRQLRPRLRSAPTHDTNVAAVEGDTIYFKPYSFSPPPSPEYPGTPRHSWTDEFRPSSSSGHSFQDNISLQIAFDLLTSELSSVMTGRPQRNGQDTAALQIWVMIEAYERLRDQLTRQEPSNAEAQKVATMFDCWLASLYSIHSSLTESTLPSPTEYAGLEEELD</sequence>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327982.1">
        <property type="nucleotide sequence ID" value="XM_011329680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZ90"/>
    <dbReference type="STRING" id="229533.I1RZ90"/>
    <dbReference type="EnsemblFungi" id="CEF84740">
        <property type="protein sequence ID" value="CEF84740"/>
        <property type="gene ID" value="FGRRES_09720"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09720"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26435"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019845_6_2_1"/>
    <dbReference type="InParanoid" id="I1RZ90"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF84740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="372" mass="39730" checksum="854004B21AE8C5CB" modified="2012-06-13" version="1">MTKTVVVLGGSLGGMAVTHQLLKYTRLRQEDLKVILVSKNSHFFWNLASVRAIITGVIKDDEIFAPIQPGLDQYPAGSAHFIVGTASAVDPEACTVTVEPETGASTKLKYDHLVIATGAETVDPSLPWKASTSHEELVASLHRTADKVERATHVVVAGAGATGVELAGEIQFAYPSTTVLLISAEDQILGGDQIAGRAESELRRLGVEIRAGLRSEETTELPDGKTLVKLSNGETIATDVFLATMGLRPNSGFLPKEWLNERGYADVDDELRVKAATNVWAVGDIVSKPRASFLVTEAQAAGVYKNIDLVLKGKEAQPVSGPRVDAFLCATGRSRGAGRLGKVSVPSLAVWTVKGRTLGIERTKKYVSGSMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZH9</accession>
    <name>I1RZH9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T26199</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF82991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327865.1">
        <property type="nucleotide sequence ID" value="XM_011329563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZH9"/>
    <dbReference type="EnsemblFungi" id="CEF82991">
        <property type="protein sequence ID" value="CEF82991"/>
        <property type="gene ID" value="FGRRES_09821"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09821"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26199"/>
    <dbReference type="eggNOG" id="ENOG502SJRA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010779_0_0_1"/>
    <dbReference type="InParanoid" id="I1RZH9"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd08983">
        <property type="entry name" value="GH43_Bt3655-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF8">
        <property type="entry name" value="ARABINOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124628" evidence="1">
        <location>
            <begin position="19"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF82991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF82991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="332" mass="37002" checksum="5C0070E059F297E4" modified="2012-06-13" version="1">MSVLALLAAALSVSLVKAVPAHKPVQKEYVGYLISTFSDPTPEVQWHLSDGKSASSFNFLNGGKPVLTSNVGTKGVRDIFLATNSKRSEYFTIATDLDINAPGFSWDWATRNGSRGLVVWSSKDLVNWSKPSLRIIESPTAGMTWAPSVVWDDITNQYYVFWASRHYAASDTQHKGEATLDKIRFATTKDFVKFSAPKDYHAPEGTGLIDQEFQCLGKPGHFVRFLKNETVNQVYQESTTTGLFGTWTRVPGYVRPESPLEGPGSFADLRIPGLYYLLLDDYTQYIPFQTSNILSPTWEKSDFPNFPKGLKHGSVTPLTKKEYDTVVAKYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1S010</accession>
    <name>I1S010_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG10021.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T07093</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318945.1">
        <property type="nucleotide sequence ID" value="XM_011320643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S010"/>
    <dbReference type="EnsemblFungi" id="CEF75351">
        <property type="protein sequence ID" value="CEF75351"/>
        <property type="gene ID" value="FGRRES_10021"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10021"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07093"/>
    <dbReference type="eggNOG" id="ENOG502QWIY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016622_2_0_1"/>
    <dbReference type="InParanoid" id="I1S010"/>
    <dbReference type="OrthoDB" id="3365616at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22952">
        <property type="entry name" value="ART10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF166">
        <property type="entry name" value="ARRESTIN (OR S-ANTIGEN), N-TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02050)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF75351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="552" mass="60633" checksum="B69FD8E9BDCFD98A" modified="2012-06-13" version="1">MSIRIALDNQPEFYTNLDFIQGRVILGINRNEQIGSIVVKLEGESGTALQAPNAFDPQNMGRIQAGPQRPPGSTATENHKILYKLQQVFPDDYYASSSNPYGAYPLQAGEHNFPFKFKLPINNACSDPMAMSKIGGMANVGGFGGGGMFGIGGVRVMDGSKQLYLRHVTRTLPPSLTGYPGEAEIRYYIKVTIQRPGLLKENWRYQIGLKFLPIEPPRPKPTTQEAFARRPFTFRPQSPQPEKKRSSLFNFGSSSESKSASNPDPSSEIAPAPAIEISARLPHPSILTCNKPIPLRLIAKKLNNNPEQVYLVSFQMELIGRTDVRALELHNQKINRWVVVSNPTINIPLTSGPDDEVGKELVIPDHVWKNIPLPNTVAPSFATCNLSRKYELEIKLGLAWGQPKKGLTTKTPPVIILPLHFAQVEVYSGITPPAELVETARSTRPGRATFTNNTPPRLPPRQNSVHVSPPQQQQPRPSQAFSQAPPQPAHDPLYPPQLAPGQDAPPYDDAPPSYDEAVAENLAGPFDGMQPRPAYSGVTNENAPSQLPPEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I1S041</accession>
    <name>I1S041_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG10056.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T07177</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318985.1">
        <property type="nucleotide sequence ID" value="XM_011320683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S041"/>
    <dbReference type="EnsemblFungi" id="CEF75393">
        <property type="protein sequence ID" value="CEF75393"/>
        <property type="gene ID" value="FGRRES_10056"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10056"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07177"/>
    <dbReference type="HOGENOM" id="CLU_2049888_0_0_1"/>
    <dbReference type="InParanoid" id="I1S041"/>
    <dbReference type="OrthoDB" id="10388030at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124658" evidence="1">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF75393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="120" mass="13633" checksum="8124C8D2FA521305" modified="2012-06-13" version="1">MSHRLLTWLWHIVRLCSENNTSDPVQSLVEMILPDLDYLSSVSCVLGSKPMSQDIVTPQREVRYQTLVENVIVAGMSKPHTDRNTRGTDDVELGQVRSLVKNPSHYGYFQIVFQCIADNV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-04-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1S0A8</accession>
    <accession>A0A098DAM9</accession>
    <accession>A0A1C3YJG6</accession>
    <name>STUA_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell pattern formation-associated protein StuA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Stunted protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">StuA</name>
        <name type="ORF">FGRAMPH1_01T07355</name>
        <name type="ORF">FGRRES_10129</name>
        <name type="ORF">FGSG_10129</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2011" name="Mol. Plant Microbe Interact." volume="24" first="54" last="67">
            <title>The transcription factor FgStuAp influences spore development, pathogenicity, and secondary metabolism in Fusarium graminearum.</title>
            <authorList>
                <person name="Lysoee E."/>
                <person name="Pasquali M."/>
                <person name="Breakspear A."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="20879840"/>
            <dbReference type="DOI" id="10.1094/MPMI-03-10-0075"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor that regulates asexual reproduction (PubMed:20879840). Binds the StuA-response elements (StRE) with the consensus sequence 5'-(A/T)CGCG(T/A)N(A/C)-3' at the promoters of target genes (PubMed:20879840). Controls the expression of the gene clusters involved in the production of deoxynivalenol (DON) and 15-acetyldeoxynivalenol (15ADON) (PubMed:20879840). Regulates the expression of genes involved in chitin and glucan metabolism (PubMed:20879840). Also controls catalase activity and cell surface hydrophobicity (PubMed:20879840). Plays an important role in pathogenicity (PubMed:20879840).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Does not develop perithecia and sexual ascospores, and lacks conidiophores and phialides (PubMed:20879840). Greatly reduces pathogenicity on wheat heads and production of secondary metabolites such as deoxynivalenol (DON) and 15-acetyldeoxynivalenol (15ADON) (PubMed:20879840). Leads to up-regulation of cell-cycle genes which promoters are highly enriched in StuA-response elements (StRE) (PubMed:20879840).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the EFG1/PHD1/stuA family.</text>
    </comment>
    <dbReference type="EMBL" id="DS231669">
        <property type="protein sequence ID" value="ESU16805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319067.1">
        <property type="nucleotide sequence ID" value="XM_011320765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S0A8"/>
    <dbReference type="SMR" id="I1S0A8"/>
    <dbReference type="STRING" id="229533.I1S0A8"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T07355">
        <property type="protein sequence ID" value="FGRAMPH1_01T07355-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G07355"/>
    </dbReference>
    <dbReference type="GeneID" id="23557049"/>
    <dbReference type="KEGG" id="fgr:FGSG_10129"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07355"/>
    <dbReference type="eggNOG" id="ENOG502QW2C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016460_0_0_1"/>
    <dbReference type="InParanoid" id="I1S0A8"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="PHI-base" id="PHI:1290"/>
    <dbReference type="PHI-base" id="PHI:1295"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000003">
        <property type="entry name" value="Ascospore maturation 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029790">
        <property type="entry name" value="EFG1/Phd1/StuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792:SF1">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0183">Conidiation</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0749">Sporulation</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000435975" description="Cell pattern formation-associated protein StuA">
        <location>
            <begin position="1"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="HTH APSES-type" evidence="2">
        <location>
            <begin position="226"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Nuclear localization domain" evidence="1">
        <location>
            <begin position="669"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="674"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="478"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="566"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P36011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="20879840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="20879840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ESU16805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000009057"/>
        </source>
    </evidence>
    <sequence length="699" mass="76878" checksum="BF7906511B0337DA" modified="2024-05-29" version="2">MDGTPSSGPPRVEAPHLLAPLQTHSQLVALTPQFKSQQSQPQSQSQYPSLINPDSYSSSSPYRLDCGAGIGQGIEDGEDYDQEESNCVTNPEPQPEHQHQYLPQLLDLVADNLEQALIVPRIHQHPQSNNCNSPESFHMMNQSHHQQSEMYYPQYPTQQYNPYPYPTNGAHAPAVSTPMPGPQNVLPVPSALSNQGAMPQAAYSNNAPAGNFDTTGQHNPPGMKPRVTATLWEDEGSLCFQVEARGICVARREDNHMINGTKLLNVAGMTRGRRDGILKSEKVRHVVKIGPMHLKGVWIPYDRALDFANKEKITELLYPLFVHNIGALLYHPSNSNRTSQVMAAAERKKNEAIVGNRSLPSLVQSHHQMMPAMPTGYTSQQPLTNGHQSMANTPQPLTNGSQPPMNGSQTPMNGPQPPMQNGGSMLKRVREDDDDLHRSGPNGHDPMNNIHGMPNGYPHQSPLGSVHQPPMQNGNDGGLKRGREEHDDMHRAGPNGHDPMNNMPGGMPSLPNYAPPPLQNLHQPLSNGDSGMLKRGRDDDDDVHRSSPNGHDANGNFELKRRKTETSTSNDMLPQSPYYTLSNGAYQGPMMNSMNHYKRRDDEAETPRPGPNMNDLNNFDLKQRHKTMESSVPAPQYDAMNRPHSSIGNSPAYASAPTGYDHLTRPASTVAVSPSYPAGPGYELARPVTNVPRRQQSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I1S107</accession>
    <accession>A0A098DCX2</accession>
    <name>I1S107_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG10400.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T08005</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319370.1">
        <property type="nucleotide sequence ID" value="XM_011321068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S107"/>
    <dbReference type="EnsemblFungi" id="CEF75806">
        <property type="protein sequence ID" value="CEF75806"/>
        <property type="gene ID" value="FGRRES_10400"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10400"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08005"/>
    <dbReference type="HOGENOM" id="CLU_1482103_0_0_1"/>
    <dbReference type="InParanoid" id="I1S107"/>
    <dbReference type="OrthoDB" id="5106274at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF75806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="182" mass="20673" checksum="2F133105B4F0D797" modified="2012-06-13" version="1">MELFSHVIIERDFPDESISNTSQMLSPINLKTIIRVLLHQPNLQAVLIQVFITKIIPRFGRKTPQATLPPPLPALRPSVRVQRVVMVSTRDQRIYKRDWCWTVAVRKGILLNFETNMQTRGKPHAVGSHGKRARTTTNTTIAYTTSDTNAKAAPLQERTRRNSIATIGYPTETGRKQTIFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1S1Y1</accession>
    <name>I1S1Y1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG10759.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T20393</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325646.1">
        <property type="nucleotide sequence ID" value="XM_011327344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S1Y1"/>
    <dbReference type="EnsemblFungi" id="CEF86033">
        <property type="protein sequence ID" value="CEF86033"/>
        <property type="gene ID" value="FGRRES_10759"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10759"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20393"/>
    <dbReference type="eggNOG" id="ENOG502QSDV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024935_0_0_1"/>
    <dbReference type="InParanoid" id="I1S1Y1"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF2">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011942204" evidence="1">
        <location>
            <begin position="16"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="273"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF86033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="513" mass="56359" checksum="4061B6B6E500C187" modified="2012-06-13" version="1">MRKAAFLGLVPAVMAIPAAVPGAAPTVYLRAAAPVAQPTEIADLQRRDIINDVETYVGGLASGIETKVKGWVNSGILDFPTGFPTGDDVKKSAGVDNDELKSEPTQVLNIPPYGNWTSKGWSVRVHGNVYKIPNLSQEKVDDLANVFLIDTEVKDLSKSQQTQARNVTKSIFVVQQDNVEVKMNFVNNVDISPDQNGGAIDARGGAQNITMPYNTTLEGDFDAFVTLKNTSGSDNGYLIPGNETSKIQTLNLYAEGKNNSGNATAYLVPPKGITIVSDIDDILRVTKIYEPKEGLLNTFARPFTPWMNMPKIYANWSTSVNDLHFHYLTTTPEQVTRNYMSFIYNTYPLGSFDTRPLNFSDVSATLSIRRFLLDKVFQTFPDRKFILVADTSNSDVMKDYPALYKDYPGQVQCILLRNTSSTDSGDKFPYNTKGFKDIPQKNYMFFHVPDDLTNLDIANGGCYNSTIKQNVTFDYQGLPFGLSDDDNAASGDVSPRLGMVLAGLVAAGLAMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1S1Y2</accession>
    <accession>A0A098E4K8</accession>
    <name>I1S1Y2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FGRAMPH1_01T20397</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325645.1">
        <property type="nucleotide sequence ID" value="XM_011327343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S1Y2"/>
    <dbReference type="STRING" id="229533.I1S1Y2"/>
    <dbReference type="EnsemblFungi" id="CEF88574">
        <property type="protein sequence ID" value="CEF88574"/>
        <property type="gene ID" value="FGRRES_10760"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10760"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20397"/>
    <dbReference type="eggNOG" id="ENOG502SDA6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006300_0_0_1"/>
    <dbReference type="InParanoid" id="I1S1Y2"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019414">
        <property type="entry name" value="Rtp1_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10304">
        <property type="entry name" value="RTP1_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="4">
        <location>
            <begin position="557"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="3">
        <location>
            <begin position="827"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="683"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="704"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF88574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="906" mass="99577" checksum="48B7BB18691E585D" modified="2012-06-13" version="1">MASSSSSTPSTGTQPKVIADIVEAGKKAFDPTSTQRQKGVEEYNKLIESTPVWKLLPALNALIKPSILPPWLRDPVLQTLTLLPLRPTGVRGTMEFVFSVHPSNVGRIPDADAGPQKQGASITHEGVAVATKLLSSVPASLTPQAWFDGISGQMFELIDGTAGPELAKTASQVVGFGVLGSKQYGAPGSPGWNAFVQPVVQDLNPSLRSMPNSGSTSIKQEDDEILDLSRDRVLTASHSLKISLQRLKTLVMSNSSPGLCRRLLRLVLIQLWVLASWHNPSQNTEENFVKPARTLLQAYLRLFGNAESIRPFVRNLLCKGVVDGTEKHWEYRLRGNSDIEVVEPRGFESAIGIELNWNELEDKATKLVECVSTACSVTEVSSIFLDLLKRWIEAAGKQTEDVKIDIRPTEGKLDSPLQNLFEVTVLQKFMDKAPEKLVSQFDQLLELVSQVLTADTQSRLADDLLAVVLSLLNLVITAPSFQKSHIKLEDLKVVESALERLSNEDRPQVTPTARNLALLLKYRDDMEENEGSASAPSAKQIEDQRTYKLAMEYVTGGDDNPAPIVSEGLNLLSSLIEKNSSILDIPAVAVLLSTLIESNDDFINLRVMKVYTQLANKHPKSAVQELLDHYLDAQERSTTDVRLRFGEALLQVIQKLGETFSGDVAQQVSETLLSIAGRRGYRPKTMAKQARDEKRQKMKKKKEDEDEDDNDMDVDEEVTEEDKARNDILAQILQGWESKRGTEDVRIRTSSLSIFGAALEINIAGIGSTLVSGSVDLCINILAMEREMETAILRRAAILNVLSFVKALDAAKKAGRKLGFGLTDDSREDIVTTLGYVAQTDNDGLVQDHAKEVIESLENWKMISMLPVQDQSNSPGLTTLAGLHVNPSGTLVDGSGKPRPRIEEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1S2I9</accession>
    <accession>A0A098DYY8</accession>
    <name>I1S2I9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG10984.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T20945</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325387.1">
        <property type="nucleotide sequence ID" value="XM_011327085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S2I9"/>
    <dbReference type="STRING" id="229533.I1S2I9"/>
    <dbReference type="EnsemblFungi" id="CEF86053">
        <property type="protein sequence ID" value="CEF86053"/>
        <property type="gene ID" value="FGRRES_10984"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10984"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20945"/>
    <dbReference type="eggNOG" id="ENOG502SP7A">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_042539_0_0_1"/>
    <dbReference type="InParanoid" id="I1S2I9"/>
    <dbReference type="OrthoDB" id="2520703at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF86053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="542" mass="62368" checksum="7DA77767360F615E" modified="2012-06-13" version="1">METSSTTRLPNEILFNILSHFCLHCQDHYNQDWDERPLRAIKPCREEQQPNAKSWYSIERNTLFAACLASKGLRDIAQPILYHEFVLGYGDSWKSDLYDWGGRLISFMQTLARRPELCRQVKVVYINTRLFTSNDEGKRATLLEAARALKIDLPAVWKQRASNILASEAEDWPEVYSIFLSTYLDESRDWTEKQERRLRRAMDQSPAPAWRWLNSELMAMLIAQTHAVQYFSIQGNRTWPTNGLPESSLRSLGVVNLPLKTLDLGIAANSLIELAPTLRTLNLHDYSGDLSAWDTELPNLKTLRITNDYLSANTLRRLLDACTGGLVAFEFEAYKRVAESPRCGFEDYENYTPAPPHMLRDSHFQPSDVIKILQKHKNTLRILHLDLTNREYRTKKIPLDVNLKDFSTLQHVFINAFQLLGSEENIEIEHEVLIRLLPRSIVSLVIHRENFRRRCRVKEALFALADSKSRSPDHFPFLKHVACNLRKRSTTVSSLRSLFEPVGVEFCTRVESLNKLKPYLSGHNGSSSLGFPVFDDSSDAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1S2Q2</accession>
    <name>I1S2Q2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG11052.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T21117</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325307.1">
        <property type="nucleotide sequence ID" value="XM_011327005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S2Q2"/>
    <dbReference type="EnsemblFungi" id="CEF88552">
        <property type="protein sequence ID" value="CEF88552"/>
        <property type="gene ID" value="FGRRES_11052"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11052"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21117"/>
    <dbReference type="eggNOG" id="ENOG502T6B0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105500_0_0_1"/>
    <dbReference type="InParanoid" id="I1S2Q2"/>
    <dbReference type="OrthoDB" id="4811040at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124694" evidence="2">
        <location>
            <begin position="18"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF88552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="229" mass="25444" checksum="B906A269CB1A1F0B" modified="2012-06-13" version="1">MLFTYLLPSLLVTSAVALPVADIGESEDNLVLFKRDDILSARDIELANIHGVDLTEMYKHSMIKRDDGDHIVVWVARDFIEANDEQGVSKRQSARPGTKSDFTSDNKADYCRDHTRHDQTGPNGPYSGGVQAMYDWARNHSGGRWPLTSSWKNLVLAGSNSGANALYKAKTTGGETSIGTKDVRNDADWTRNRAREFSGRGWRASSKGGETCGLQVRINYEIVKTDYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1S2Q9</accession>
    <name>I1S2Q9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="3" type="primary">FG11059.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T21133</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_011326998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S2Q9"/>
    <dbReference type="EnsemblFungi" id="CEF87669">
        <property type="protein sequence ID" value="CEF87669"/>
        <property type="gene ID" value="FGRRES_11059"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11059"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21133"/>
    <dbReference type="HOGENOM" id="CLU_1525230_0_0_1"/>
    <dbReference type="InParanoid" id="I1S2Q9"/>
    <dbReference type="OrthoDB" id="3435011at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F-box-like_dom_sf"/>
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        <property type="entry name" value="F-box_dom"/>
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    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
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        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF87669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87669"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="183" mass="20406" checksum="496EE3BF83B96F72" modified="2012-06-13" version="1">MSTPTTEEPFTIFHKFPPEVQLEILRQCSEGDLVCLSLTCRDMHYLAKPLLSEKPDLSKVDQLGSTPDMPQDCMDSDYQYGTTTRRDMLLATNAEPIRLNTLFVKSQGARNTVHVFHALSSCDCATGWGVESIVVCMEGKRSEKLQITIGLREKACHMDIDGGEDGGRTTLITRHINQMPSRG</sequence>
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    <accession>A0A098DZ21</accession>
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        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
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        <name evidence="3" type="ORF">FGRAMPH1_01T21759</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325931.1">
        <property type="nucleotide sequence ID" value="XM_011327629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S3D5"/>
    <dbReference type="SMR" id="I1S3D5"/>
    <dbReference type="STRING" id="229533.I1S3D5"/>
    <dbReference type="EnsemblFungi" id="CEF86093">
        <property type="protein sequence ID" value="CEF86093"/>
        <property type="gene ID" value="FGRRES_11313"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11313"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21759"/>
    <dbReference type="eggNOG" id="ENOG502QQ7T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_402257_0_0_1"/>
    <dbReference type="InParanoid" id="I1S3D5"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
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    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
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    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="114"/>
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        </location>
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        <location>
            <begin position="495"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="114"/>
            <end position="193"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
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            <begin position="521"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51212"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF86093.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF86093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="621" mass="63243" checksum="D244D8BF6AF133B5" modified="2012-06-13" version="1">MFCTDCRKNKREIRSPCVFEVLVNGEVISAEPIVSSSQGALSITTNPVGEKESYELVFRQTCNGEIIDALLSGVTIKGSAGATSKPIPPVNIGPETGSATTNSEGDTIVPTATDSAGFTTNSEGQTVFPTDTNSEGATTNSEGETVFPTETQTGDSTNSAGFTTNSQGETIFPTETQTDDSTNSAGFTTNSEGETVGPTGTATGTSPSSSSASPAGFPSDISAFTLFGCVGSTVGFPTFELAESNGSMDLDACSILCEGRAYFGVYDTSCHCGDEVNAADTSRVNLDQCDIECPGDDNQFCGGESRADKLRARQNVSNSRLLTVYVATEAAITVTDSVAQTVTDQETVITTFTTTVTGATGITTQAITATLVCFSGKCYSTSSSYVTVYIFVGINSSECDGQWVYISEPCSCAGGQRYVPQFCTGGSCSGLKVYKVEECHDWYNYNSFFVPSDCATCAEGRVMYQPWEKSWGTPDNCNGDVPVCNGYDCPSKPNGGGSHAGGKWNSTAPHGGSQNGTSGWSHGGSNGGSQGGSNGSSSSSHETPNGNSNDGSEGISSSGANGSPSGASGAGSQAGSHGSNSGGSQGSGTGGQPSTAPIVVSGAGKQTTGALGLLTILAALL</sequence>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316436.1">
        <property type="nucleotide sequence ID" value="XM_011318134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S4Q0"/>
    <dbReference type="EnsemblFungi" id="CEF72723">
        <property type="protein sequence ID" value="CEF72723"/>
        <property type="gene ID" value="FGRRES_11818"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11818"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01845"/>
    <dbReference type="HOGENOM" id="CLU_2320600_0_0_1"/>
    <dbReference type="InParanoid" id="I1S4Q0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF72723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="99" mass="10659" checksum="D1317E4CAA6F1F8F" modified="2012-06-13" version="1">MTTTTGAQGSRFFQALGVPPVSRCMTETLQLSCRNRPPSSDRQAAVYFSQSLAIDAESCDIDSINTTSAHASSPGYRTLLEGSLSVFAQYSKPRITAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I1S4R9</accession>
    <name>I1S4R9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T02101</name>
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    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316558.1">
        <property type="nucleotide sequence ID" value="XM_011318256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S4R9"/>
    <dbReference type="EnsemblFungi" id="CEF72850">
        <property type="protein sequence ID" value="CEF72850"/>
        <property type="gene ID" value="FGRRES_11837"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11837"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02101"/>
    <dbReference type="HOGENOM" id="CLU_2158624_0_0_1"/>
    <dbReference type="InParanoid" id="I1S4R9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF72850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="111" mass="12244" checksum="EF9B606F2CEAD351" modified="2012-06-13" version="1">MFWDGSSQVGTCLISAETVNGRDSDYKHSFRGMVRGTNTHDEIVEPLCLILVNTALICYRPLDRTEMGLGFHPLLYPLQSHASSVSTVLRVSENLTAKSISDEISSSYYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1S5X2</accession>
    <accession>A0A098DM21</accession>
    <name>I1S5X2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T15467</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CEF79535.1"/>
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        <property type="protein sequence ID" value="CEF79535"/>
        <property type="gene ID" value="FGRRES_12243"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15467"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF79535"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="293" mass="32006" checksum="C86BFC479305744D" modified="2012-06-13" version="1">MSERPTYILAPNWDIPPNEHVRLGNIITHPRLPLESLNSESRETPEKITPSKKPNWSLTYSDLRSLDAGIMTSFLASLLGLGGDIAGKTSSTKGSVLTCQELETSYFIPNDTYIARSLAKTTVKTYMKKNPLKSVYMVTGLKIAHGGSIQRDKNNSIGADAAVTVDATPLLGAPVENTPHISFERSHNQVLSFGVCDEPFIVGYQLLKIKTKLSGRTKTETFDKFALLSDDQDRASVDQVALELLNENFSIQPIQEPSDIDEDEEVDEESSGVWCATGLLDDSTGGDGGSHME</sequence>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321501.1">
        <property type="nucleotide sequence ID" value="XM_011323199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S629"/>
    <dbReference type="EnsemblFungi" id="CEF79085">
        <property type="protein sequence ID" value="CEF79085"/>
        <property type="gene ID" value="FGRRES_12300"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12300"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14565"/>
    <dbReference type="HOGENOM" id="CLU_2333775_0_0_1"/>
    <dbReference type="InParanoid" id="I1S629"/>
    <dbReference type="OrthoDB" id="10358693at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
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    </feature>
    <feature type="chain" id="PRO_5010124785" evidence="1">
        <location>
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            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF79085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="110" mass="11898" checksum="F1C27238B9FE37DA" modified="2012-06-13" version="1">MSLDGCCAVLFLMLLANKVGSWQAQRRNPAAICCIIRYSLYWVLKAAAVLQSQQHGALCRLWIPSPCNAAIERPGGQSSGPVMVRNGKATGSRLATAARMCTWRLGSLPH</sequence>
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    <accession>I1S6H8</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
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        <source>
            <dbReference type="EMBL" id="CEF78163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="102" mass="12032" checksum="4B8FCB8A19C486B2" modified="2012-06-13" version="1">MNHRLIGVFKKPRSGKSVVGRLFVDICMGHIDRQSLFSRHELSHLTQILLFKWSHIWQGSRLYLPITAQTDKLRLVPAWLYDVTMSRNANVSYLMTRFFNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1S8Z2</accession>
    <accession>A0A098DDL8</accession>
    <name>I1S8Z2_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
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        <name evidence="3" type="ORF">FGRAMPH1_01T10531</name>
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    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320069.1">
        <property type="nucleotide sequence ID" value="XM_011321767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S8Z2"/>
    <dbReference type="STRING" id="229533.I1S8Z2"/>
    <dbReference type="EnsemblFungi" id="CEF77068">
        <property type="protein sequence ID" value="CEF77068"/>
        <property type="gene ID" value="FGRRES_13321"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13321"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10531"/>
    <dbReference type="eggNOG" id="ENOG502S5WK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098391_1_0_1"/>
    <dbReference type="InParanoid" id="I1S8Z2"/>
    <dbReference type="OrthoDB" id="19690at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="90"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF77068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="246" mass="27292" checksum="CE8EB154D55B1616" modified="2012-06-13" version="1">MAFKRCPVRPITGLSYCELSPVGSATPAYRRVLEPLDQGSLREIRPHKKYYLKKKTQCIHSLYALDYARYTARHRLYGLSQFNEPQSHQAHRDKPRTKYTPPSIRNNDSFSTYISLSTSSRTPLLTFWSASWCSTCKAVSPLLHDLVESGIGEEEGGVSLATVEFDSPDIMSGDPNLAMTYMITSIPTLLSFDGGEAQTATKLSDARKLADREFLKEWIRTEARRHGGRGGGGGGSSLFGGLFSKS</sequence>
</entry>
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    <accession>I1S9W3</accession>
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        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
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        <name evidence="2" type="ORF">FGRAMPH1_01T26297</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327914.1">
        <property type="nucleotide sequence ID" value="XM_011329612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S9W3"/>
    <dbReference type="EnsemblFungi" id="CEF85231">
        <property type="protein sequence ID" value="CEF85231"/>
        <property type="gene ID" value="FGRRES_13644"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF85231"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="104" mass="11631" checksum="4B818D5FF040AD8D" modified="2012-06-13" version="1">MHAVGTQARGYGEKLPAEQCTISSLARYSVSTIGRVDAASRCPCRNETASHRIASHRIDEASSLQTYQRILLNSTILLCTEYILFGYIYGKTRPIVNQPELELR</sequence>
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    <accession>I1SAB2</accession>
    <accession>A0A098DAP4</accession>
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            <fullName evidence="3">Chromosome 1, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF76038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319589.1">
        <property type="nucleotide sequence ID" value="XM_011321287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1SAB2"/>
    <dbReference type="STRING" id="229533.I1SAB2"/>
    <dbReference type="EnsemblFungi" id="CEF76038">
        <property type="protein sequence ID" value="CEF76038"/>
        <property type="gene ID" value="FGRRES_13793"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13793"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08471"/>
    <dbReference type="eggNOG" id="ENOG502RYAY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1151885_0_0_1"/>
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    <dbReference type="OrthoDB" id="5429634at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="198"/>
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        <location>
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            <end position="215"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF76038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="241" mass="27148" checksum="145B37177693CF63" modified="2012-06-13" version="1">MVVGMAKLTGSFGFTLRHCLAATMMEIPLSSMPHSNEKSITCSTHMAQFSTWKKTALYLTCLVTALTTLLIILLFLSLFHPEQNEIYASRISRDEDALGLSILYEGDCKETAKIDLWLHLVIKIIGTSILASSNFFMQGLVAPVRAEVDAAHRSGHWLEIGVPSLLNFRFLSRRKIIYWSLFCLSSVPLQLTFNGAVLEARSTNAAMVILGAEELVKGDWYIRDPIYYMSMENYRNSQREP</sequence>
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    <accession>V6R5P0</accession>
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        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321726.1">
        <property type="nucleotide sequence ID" value="XM_011323424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6R5P0"/>
    <dbReference type="STRING" id="229533.V6R5P0"/>
    <dbReference type="EnsemblFungi" id="CEF78844">
        <property type="protein sequence ID" value="CEF78844"/>
        <property type="gene ID" value="FGRRES_03941"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03941"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14083"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_2_1_1"/>
    <dbReference type="InParanoid" id="V6R5P0"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="80"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF78844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="292" mass="31460" checksum="5F32F21190DEDA55" modified="2014-02-19" version="1">MDTTTFKRLVRFVPKSDSTRILIGEPSQEDLDIGVATRDGKDVTVNVFTGSSVLSPGTRTDRTESIERILSPLAQEEVGTIRCIGLNYVQHANEVKMDIPKIPTLFLKPSTALGDPWPAPTFLPKITQNDGSGDYESELAVVIGKTAKNVSEENAMDYVLGYTAANDVSSRVSQLNQSQWCFSKGFDGACPIGPVLVSTSAVPDPSKLHIRGLKNGKVLQDCSLDDLIFSIPKLVSFLSQGTTLPAGTVIITGTPAGVGMGKSPKENLEHGDEFRVEILPHIGTLVSKFENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>V6RS95</accession>
    <name>V6RS95_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG10191.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T07509</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319139.1">
        <property type="nucleotide sequence ID" value="XM_011320837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6RS95"/>
    <dbReference type="FunCoup" id="V6RS95">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF75558">
        <property type="protein sequence ID" value="CEF75558"/>
        <property type="gene ID" value="FGRRES_10191"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10191"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07509"/>
    <dbReference type="eggNOG" id="ENOG502RCWJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097615_0_0_1"/>
    <dbReference type="InParanoid" id="V6RS95"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387:SF3">
        <property type="entry name" value="DUF985 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="RMLC-LIKE JELLY ROLL FOLD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF985" evidence="1">
        <location>
            <begin position="31"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF75558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="223" mass="25207" checksum="4DD7E7AAD266BB29" modified="2014-02-19" version="1">MGDFIDSKLDLSTIKPSFSTSSEPESPRSKSLIEALSLELHIEGGYFRQTDADPTTIPSTYSSKPLSDQTLALTGGTREGYSTNTRRLSTTIFYLLTPRQSKGNFHRNRSRVIHTLHRGRGRYVLLHPDGRIESFVVGNAVERGERLQWIVEGDVWKASYLLPSESNPSHETDGTETDGLLISETVVPGFEYEDHAFLTHQGIKELLKEEQVRELEWLVRKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D2A5</accession>
    <accession>A0A0E0RPA9</accession>
    <name>A0A098D2A5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T02565</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
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                <person name="Regev A."/>
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                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
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        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
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        <citation type="submission" date="2017-01" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
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                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
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                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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        <property type="protein sequence ID" value="CEF72807"/>
        <property type="gene ID" value="FGRRES_15783"/>
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    <dbReference type="eggNOG" id="ENOG502S2DX">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D332"/>
    <dbReference type="STRING" id="229533.A0A098D332"/>
    <dbReference type="EnsemblFungi" id="CEF72361">
        <property type="protein sequence ID" value="CEF72361"/>
        <property type="gene ID" value="FGRRES_00431_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01119"/>
    <dbReference type="eggNOG" id="ENOG502RIGC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098D332"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="888"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF72361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="915" mass="101613" checksum="A7FE8CB3596EC192" modified="2015-01-07" version="1">MGLFSTALRRHRHRAGSEVDLLSAAFGFPFSHGIKSSCNKSPGRMKIVYDPPSDSSNESDSDETSSSSSENDRGRQQHRGRRLSERPPTPHRSTPASLSSSKKSSSRKKHHRRRRSRTSSRSSPQKSTRSRTSRSTSRRSNVGSMTSQPSIPYVQSSATFPPPIPVNLSKPPCNIVQSKTFPISTFNQPFGLPVCQPMPQQQVYYQPPFNYGPPQPSSMYRGPAPQFIAPAMPVMAQPPPGITTVPVSSATPNSSAISPGASGIDSKKSNSEAPDQSDSWNKDIQRLQKHIDAKMVDLSSEPNSKVLRRDLRRLQDRLNSTLNKAITHSKKSHARKLSLSSTSNFSQLALDGDTTSEATAATLRGLIAPTSTIKNDHQRQYHAQQGKSPQRIPRHHVCSGCGNVRSQQFHKRWPLNSSRKSYKISYCESCREEMYNRGIVQKYHFCFNCGAARSMAFHNRHPVLPGEPIFVNYCGSCTEEFKVYERLPDISVVNLVAPRVKSHTEVTTPSDSEDDLDSITVNRHQNSKSGQTSVKGDQQHEVKLERPGPDTEPPRGRRPEPRTPKQSIVASDVDFVPPESPYCPSRSTGSSGRRAERKSSLQFSTGSSPHREEFETKGNYRAPYVEDSSSSHHSRVATPTSSIRSKTREQKMKSKGYGSRKSPSPDVVLKSALAGSDRSSSDGSRKARAETSDESPRVRGKSLDSDRSDPSSSKSSSSKTVRFKQSVDIRTALPQDVDDFSEPESPRYPRSPGSPLISRKQSTTRRTKETRDQYLHPHYGQRSNSSPGFHREHLHTPDNFMPGTPSKGYSKGAFSKDFDGGGHWDSFQSPGYSYADHYSESSFRGYCDADEDYSASQPYNHDQYRESTASLPSRLSTGSVFASFFKKDKASSVPPRDRASPRPFAHDFNETARDN</sequence>
</entry>
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    <accession>A0A098DDH8</accession>
    <accession>A0A0E0S0K4</accession>
    <name>A0A098DDH8_GIBZE</name>
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        <name evidence="1" type="ORF">FGRAMPH1_01T10453</name>
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    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DDH8"/>
    <dbReference type="EnsemblFungi" id="CEF77029">
        <property type="protein sequence ID" value="CEF77029"/>
        <property type="gene ID" value="FGRRES_15499"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10453"/>
    <dbReference type="InParanoid" id="A0A098DDH8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF77029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="65" mass="7390" checksum="2C7D0E2814ABB0D7" modified="2015-01-07" version="1">MASPIYKPTSVENPQANVPVSYPTPVSFVPVQDTRTRLLKVYLNCRSTCLKREKRHTTTAVNKQQ</sequence>
</entry>
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    <accession>A0A098DDP3</accession>
    <accession>A0A0E0RZ92</accession>
    <name>A0A098DDP3_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T09529</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DDP3"/>
    <dbReference type="EnsemblFungi" id="CEF76567">
        <property type="protein sequence ID" value="CEF76567"/>
        <property type="gene ID" value="FGRRES_13043_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09529"/>
    <dbReference type="eggNOG" id="ENOG502RPHM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DDP3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="486" mass="56233" checksum="599B3F7B80F0432F" modified="2015-01-07" version="1">MCHLTIYHFTRCDTQRRVIINPTIGATAYHPFELPPPCHHSTNEPLPAPEDPNAAAPCPVHGPCCHPGQVFVCEQKDDPKARCMGWQANHRILEPEMLELFDSNLLPITYEHWRTMSDNSDEFAYEEDIRREFFDAGAKMWDLWNWGQEIIDIISHSQSHPFGAKIEREDVLDHGECYWNWMIARKELLQLTEAWEDLASMGCMEVCPSKLLAVHPWMKYAFHGWNERQPVDFPQFRGIPFRSVKNLERQRDILRWHPYYARRDMPSTPNLVERLWKSPTIPQTHNPELPHELGNENMGWPAEWKGIYDVAARRDSLPLRKYAEPSNLYSMQGSVASAPIQPEPQPEKQYGPQYTSESEPNYDDGYESPSTHSSGPRTPPWAIPYGQEPKKIKWGPVNWDQAATFVQSPPVSPETVPSRPIPSMVRVYNEESLSKLKHFVPREGMLDLIPLSDSESDSEEVRRLKRRRSEDDGKTGMKPVKKYRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DEL8</accession>
    <accession>A0A0E0S1P8</accession>
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            <fullName evidence="6">Chromosome 2, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A098DEL8"/>
    <dbReference type="FunCoup" id="A0A098DEL8">
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    <dbReference type="STRING" id="229533.A0A098DEL8"/>
    <dbReference type="EnsemblFungi" id="CEF77423">
        <property type="protein sequence ID" value="CEF77423"/>
        <property type="gene ID" value="FGRRES_08941_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11241"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Aldo/ket_reductase_CS"/>
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        <property type="entry name" value="Aldo_ket_red"/>
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        <property type="match status" value="1"/>
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        <location>
            <begin position="68"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
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            <position position="101"/>
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    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="160"/>
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        <ligand>
            <name>substrate</name>
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    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="129"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF77423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="357" mass="39839" checksum="D91406286BC2CE66" modified="2015-01-07" version="1">MFMMWQQFITSRSPALIRTSSSPLVFCSRPRAYKYTPFNPLHRLLFCELYTMAPSTFKLNTGQEIPAVGLGTWQSPAGEVEKAVTYALKDGYKLIDCAYCYGNEEEVGAGLKAAFKAGVKREDIFVVTKAWATYNTRVELALDKSLKALGLDYVDLFLVHWPLLLNPDGNDDKFPKKPDGSRDVIRDYNHVDGWKLMEKLPATGKTRAVGVCNYSKKYLEELLPHATIVPAVNQIENHPELPQQEIVDFCKEKGIHIEAYSPLGSTGGPVMSAEPVVKIADKKGVSASTVLLSYHGNTVLAKSVNPERITANKTIVDLDDEDMKALNDYSAELQKNNQVKRYVYPPFGIDFGFPDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DFK6</accession>
    <accession>A0A0E0S2M4</accession>
    <name>A0A098DFK6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG03031.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T11893</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DFK6"/>
    <dbReference type="STRING" id="229533.A0A098DFK6"/>
    <dbReference type="EnsemblFungi" id="CEF77749">
        <property type="protein sequence ID" value="CEF77749"/>
        <property type="gene ID" value="FGRRES_03031_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11893"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DFK6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="221"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="368" mass="41726" checksum="53093F3B8AA10706" modified="2015-01-07" version="1">MTERAVIPAESRFRRALYALPFLAITALMTRAFGMAEPIGPVIEEMVKTSVFTTSSANIPIIKGFYGISVLDGIFNVVTVAFANLQFYFDEKAYWQSLVFLTDFAGMYAVVQLEAYRPGNTFIISKYPVVFLFVSQMIAIGCTAPIFFFLAYVFTPAYKLTTPSLGRLSVGTCKAIYVAIILGYYVPHFPSYFNASLERRNWWNWIWQLFPVWCCSITFAFSKVFARMNKSNGKLNPERDALRILMGGCSVLSMGVWWYTVASMKGSIFEVFVPQYLITYPQEPSLGLRTVIQFDYICCYAAGYMWLAYHFRDLEKVGVCSISWVRAISVTVVLGFLVGPGTLFPILWLLREELLMAANGEEMKEARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DFP2</accession>
    <accession>A0A0E0S2Q9</accession>
    <name>A0A098DFP2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG03062.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T11963</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DFP2"/>
    <dbReference type="STRING" id="229533.A0A098DFP2"/>
    <dbReference type="EnsemblFungi" id="CEF77784">
        <property type="protein sequence ID" value="CEF77784"/>
        <property type="gene ID" value="FGRRES_16342"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11963"/>
    <dbReference type="eggNOG" id="KOG4231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DFP2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07199">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="602"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="11">
        <location>
            <begin position="670"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="8">
        <location>
            <begin position="674"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="8">
        <location>
            <begin position="707"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="8">
        <location>
            <begin position="876"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="709"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF77784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1218" mass="137733" checksum="A8A5DA68613F2D49" modified="2015-01-07" version="1">MHCNETQCDNCWSTQRKHKKPDPGHNKTSLEDAIIVHSTLNVRLDEYGLLKDQIERLRTPEPRRLDRIASEWFGVKPKNDDGEFLLTEGLAYDLIMDPVWTSASSIYPGLVSFIGATGSGKSSLISLLSKFSSSPLRNLFETPTVGDSGSTDSTSSNVNLYSDPDSFLKENPLLYADCEGMDGDEMPAAMRNTPPSAFQTWGLDARDITWETEPGNGGIWTRRVITKTLFPRILYIFSDVVVFVPHNRIGLEEYIFQLAQWGYSATVQAYNKPVLPGVIIAFVNRDGQVDPKDYDLDKAKDSLFDKPSFKDITRDPKLQEHVGYWAENGQKITTAEELLLCYYSSINVVQFPDGKDPTRMRQQIAKLYQKINTVCSDLRKQREIALMKWDASTLPRFIRKAFTHFACNYQIPFNFSDAWVDIQRLSFNYEGSIFDLAIKTQKARGISGWELWEAISVFSASCLFLNCVRENQPGCRPSELHWEQFDKAAERYWNKFWPCKFHIEGKDGTQYCVNAPSGHPHHQIGQNIRGEDKSHEASHTPEQLKTSFREPVDNAFRQFKSRLKGKDWHARSEEALKIHQQQIPVFYNTIPDIDEFLSHSTCLICLNGVPEHSLPCGHIICRLCARDVGNPNSGGFLRLTECPLHVHQKDLWIQGWAGFDKPSQAGLRILSLDGGGIKGVVIIEVLKRLQTCLGKIPIRDCFDLIVGTSAGGIIAGALGPGGLTIEDCGDKFVEVSNKAFTKPKPSIMPAKVGFLVNKMTAFLNHGLYLSEPFETSLKKELPDIPTFGGNYKFKKPSVKTAITTSTREGQVIVLSNYNRVPPKQAFYQLQRLGPGHEMRLWEAARATSAAPLYFPPFCREGNFDTTTEGTKQVYLDGGLWHNNPIRIADSEAAAIWPENTHAHPDILLAIGTGYHESEIHANNGTQVYLEQIINDAVPGAQSAKEKSFLRGIAETGMNQFTSSLNSERIWHEWLQAKSPSTEFESRYRRVNVEFSRVVPMDTPTTEAYDCCQEAVRKLPDDLFESIADQLIASCFFFRIDRQATPEYPREAYQCHGVIECRLQPEAIKLLGQRFESMHVMHKLPFFTIKETHKNGPDPVKSVSIESVVAQMKDKGQFQIPLTVEVTSELAETEILLHMRQKGQVISGLPRRLKDDEDDGVYEAVGKRHDQASRLRPLVDFILRRTSSEAWMSPPGSDTSSKWRHNSFKRILIKRKKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DJP8</accession>
    <accession>A0A0E0S5A7</accession>
    <name>A0A098DJP8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG03809.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T13759</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DJP8"/>
    <dbReference type="EnsemblFungi" id="CEF78682">
        <property type="protein sequence ID" value="CEF78682"/>
        <property type="gene ID" value="FGRRES_12378_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13759"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DJP8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="352"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="924"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="293"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF78682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="981" mass="111431" checksum="2052C08C107F41CC" modified="2015-01-07" version="1">MTQKVAETHVLRPGAISTGRAKHACFNHIMSIIALHGLDATSPETWIGWKVDGDPNSGDVNWLEDKHMLPRFMPDSRILTYQWNANYDAYASSDRFSGHATSLLQDLHADRFSECRSNCPIIFIVSCFGGLLLAQALVIASHPTEPGHRQHSSILRHTIGAAFLGTPFGGSPLDDLANQFGNLIHSDKYKFPVMCVYETRHTDLSAYKRRLGANFSSMGLDENYHGIVVDSKSATISGMEAYGFDVRHNMLHKFNDSNDVNFKKIRHWLVKTADIAGETLGCKASNDRPVNDLYDDRSHSGSKSDTRLFDLPGSRVRKNPRKPEAREKLYNKLHFKTLGERYKNIWPAHRATCKWLLKNKEYQAWLDKGKLEDHHGVLWLKGNPGTGKSTLMKFAVSKLSMENPKDIHIFFFFNARGDALEQSTVGMYQSLLHQLFSQIPRLKYVFDDFAQFDLPETDIYESWALQTLESLLMHAISELGSHKLWVFVDALDEGNEKEVRKMITFFGGLGKEAKDANVDMRVLFASRHYPQITISHKVEIILESEKEHYLDIKRYVQSELYIKDGMTAQGIQDEVINRASGFFLWVVLVVEILNETAAKGMNQKEKLKELPDHLSTLFEGILTRDRENMKGTLLCIQWVLFSRKPLTREELYYAILHGANEKETRSWAADYVTIEIMDAFILTCSKGLVQFSGETAQFIHETVRDFLIHDNGMQLIASDATKSIKGAAHDTLKSCCLNCISSTLKIIWGSGRPVRFDNLDRLRGIYDSIVESGRKNYSKSKPLYKTPFLHYALFHLLHHANAAEAGGVSQVSFIQAFQLRSWVYLRKVFLELGTFNSLRSTFLYTLAEEGLGSLIMAMLHADPGKTPHLLVEELLRHEDVELNFRDAEKGRTPMWCDAEEGYEAIVKLLLERQGVDVESKDTEYGQTPLCVAARFGHREVVRLMLVSNRVVLGSQDLQGQTAWTWAIIRQDDAMMEMLGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098E305</accession>
    <accession>A0A0E0SPX7</accession>
    <name>A0A098E305_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T21073</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098E305"/>
    <dbReference type="EnsemblFungi" id="CEF88490">
        <property type="protein sequence ID" value="CEF88490"/>
        <property type="gene ID" value="FGRRES_20308"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21073"/>
    <dbReference type="InParanoid" id="A0A098E305"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF88490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="55" mass="6500" checksum="FB492870366F04C8" modified="2015-01-07" version="1">MSSFPQSIAEEYYPIRSTSLELQRLRYSYLYRYDEVWAADADLPPARPSLQLTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098E4T4</accession>
    <accession>A0A0E0SQH6</accession>
    <name>A0A098E4T4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T20999</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098E4T4"/>
    <dbReference type="EnsemblFungi" id="CEF88689">
        <property type="protein sequence ID" value="CEF88689"/>
        <property type="gene ID" value="FGRRES_15630"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20999"/>
    <dbReference type="InParanoid" id="A0A098E4T4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF88689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="90" mass="10113" checksum="77925757C6796ACE" modified="2015-01-07" version="1">MRPSELAKLTADELAVSIKPILTELLQRSSQETATAVAAEIIDEVVAKPLAQVLKVVEKDAWNDYDGCLEDYEEWLSGLDMWETDESEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098E4Y5</accession>
    <accession>A0A0E0SQQ6</accession>
    <name>A0A098E4Y5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T20783</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098E4Y5"/>
    <dbReference type="EnsemblFungi" id="CEF88769">
        <property type="protein sequence ID" value="CEF88769"/>
        <property type="gene ID" value="FGRRES_20303"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20783"/>
    <dbReference type="InParanoid" id="A0A098E4Y5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF88769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="77" mass="9381" checksum="202CC24FAF4E8493" modified="2015-01-07" version="1">MSFRLVLVLKEDRRCFMHLAGWDAFFVYWVLFVIAQRWVLILQDNYIVINEVWLCGTNQRSRHILPTMRMLHIGPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RNI4</accession>
    <name>A0A0E0RNI4_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">FG00805.1</name>
        <name evidence="15" type="ORF">FGRAMPH1_01T02017</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-malate + NAD(+) = pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:12653"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>oxaloacetate + H(+) = pyruvate + CO2</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="1.1.1.38"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RNI4"/>
    <dbReference type="FunCoup" id="A0A0E0RNI4">
        <property type="interactions" value="890"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A0E0RNI4"/>
    <dbReference type="EnsemblFungi" id="CEF72809">
        <property type="protein sequence ID" value="CEF72809"/>
        <property type="gene ID" value="FGRRES_15784"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02017"/>
    <dbReference type="eggNOG" id="KOG1257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0RNI4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000001">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000055">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF34">
        <property type="entry name" value="NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="14">
        <location>
            <begin position="126"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="13">
        <location>
            <begin position="317"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CEF72809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="640" mass="70562" checksum="0377AA792CBC4B8A" modified="2016-04-13" version="1">MRSLNNNYATQAEKSQSTTTKNKSNSKYENLPLSTSGPINCALSGTSLLNTPYLNKGSAFPPDERRAFNLTGLLPQGVQTLEQQCKRAYEQYSSRPDDLAKNTFLTSLKDQNEVLYYKASYLPACHEGITDCQIQLIQTHLDEMMSIVYTPTEGDAIQNYSRLFRRPEGCYLNIQDPDHVEHNLAQWGNPEDIDYIVVSDGEEILGIGDQGVGGILISVAKLVLTTLCAGVHPNRTLPVVLDCGTDNKELLEDELYLGLKEKRVRGEEYAKFVDTFVQSARKLYPNAYIHFEDFGLGNARKILERYRPDFACFNDDVQGTGCVTLAAILSGLHASDQKLKDLRMVVFGSGSAGLGIADQVRDAIATEGNMSHEDAANQIWLIDKSGLLTSETEDVTESQKMYIKDVSEWKDKDADLLSVVKEIRPNVLVGTSTKAGAFTEDVIRAMTEHHERPIVLPLSNPTRLHEAKPEDILNWTDGKALVATGSPFPAVKGPWGKNGEEITINVGECNNSVVFPGIGLGCILSRAKHLTDRMLVAAVEGVSSLSPVLKDSTAPLLPDVGSVRDVSVRIARNVIQAAVKDGEATQEGIPEDEEDLEEWIKEQMWDPEYRPLKQVDLESATREARGELKKAGTVHRTGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RP36</accession>
    <name>A0A0E0RP36_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG00962.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T02419</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RP36"/>
    <dbReference type="EnsemblFungi" id="CEF73011">
        <property type="protein sequence ID" value="CEF73011"/>
        <property type="gene ID" value="FGRRES_15014"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02419"/>
    <dbReference type="InParanoid" id="A0A0E0RP36"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="206"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF73011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="275" mass="30051" checksum="34049089BE7D3EB9" modified="2016-04-13" version="1">MIHPTVLYLTLSVALLVIAVIVHVRSSNLSLAISPAVSIITVILPIVGFLNTACYPSFRRTTKSSPSRVAQLGPLVVQVLQALITTILATLLFERALPSGVTNCMMENQWMSMFRAHDAGGIRRIQDAFDCCGFNSVRDRAYPFPGTAPSTCAATYGRRTACREPWQGALQTNAMADFAVVVGVGLIQIMGLFVVPESGNWRNAWGVNRSGERNQQSESRRPLLIDRERDVVEEEETEPEQPEGESQGYGSLNANVSGSRVVPSSVAERNNWADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RVD7</accession>
    <name>A0A0E0RVD7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FGRAMPH1_01T06815</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RVD7"/>
    <dbReference type="FunCoup" id="A0A0E0RVD7">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A0E0RVD7"/>
    <dbReference type="EnsemblFungi" id="CEF75212">
        <property type="protein sequence ID" value="CEF75212"/>
        <property type="gene ID" value="FGRRES_17291"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06815"/>
    <dbReference type="eggNOG" id="KOG2000">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0RVD7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000923">
        <property type="term" value="C:equatorial microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008275">
        <property type="term" value="C:gamma-tubulin small complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061496">
        <property type="term" value="C:half bridge of mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:inner plaque of mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071957">
        <property type="term" value="C:old mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="211"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="513"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="111"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="777"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="856"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="777"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="866"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF75212.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF75212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="877" mass="99012" checksum="0203D40EEB57ACC5" modified="2016-04-13" version="1">MAPDRITNAIDSLIAHIVPSDPNDPDEVAQERHDTCFEIVKSILDSPASPAISSDVNHASDLIKRKLIQSNPTQALRFSNLYTRLLSLPVLEHKWAILYLLYQLADSPDPNEPLPLSPVKPSAPNYRDAINRDAIKRQGRERVTKTSRFEDEQFKEAFQPDGLKKFPPKESKQPSKEGEPCPEPPKRDVSLKSTLLANNYSEIEPPESVILRDLPFTLQGLSSTTLPFSKSDIIKLPSTLPLPIVSLLHTLAEPSLLYRGLDGFCKTPAKGLLGQSLRAAIHGELKSYLSLIATLESQIRRALASLDDDAPREGIGKAGVTLKRCVVWTREATMGLRLMSLIAEESEKKRGGQLVSLIHSFSSSHGDPVVAAFAERLLTSFTRPFYDILRHWIYDGELSDPFQEFFVREQSPNKDTTKAKGAGNVWEDKYEIDTDMIPSIITQDFAQKVFLIGKSLNFIRHSCGDAMWVEDYSKAASKELRYGDTATLEAWIDEAHKTTMKRLIDLMANKFHLFKHLQALKNYILLGQGDFIALLMESLAANLDRPAGAQYRHTLTAQLEHAIRGSNAQYDSPEVLRRLDARMLQLSHGDIGWDCFTLEYKIDAPVDVVVTEWGNRQYLKVFNFLWRIKRVEFAVLSTWRKCMTGARGVLQNSDPAVSQTWKSTRGVLAEMIHFVGQLQYYILFEVIESSWGELQKRIHKEDCTLDDLIKAHTRYLNDITHKGLLGAKRRTHSSDEDDRTTYMMQLGEILRFMLNYRDSVDGLYSWSVSDFTQRQEADVRSTTRHTDDHDGLDTPTADSGAVTSEFPVLQERLRHLGASFRTRVQILLGDLAYQPDVDMRFLGVAMNFNDVYQPTRRKSKAAPGTGATTRSVSTNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0S2J9</accession>
    <name>A0A0E0S2J9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T11843</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0S2J9"/>
    <dbReference type="EnsemblFungi" id="CEF77724">
        <property type="protein sequence ID" value="CEF77724"/>
        <property type="gene ID" value="FGRRES_15168"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11843"/>
    <dbReference type="InParanoid" id="A0A0E0S2J9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF77724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="67" mass="7530" checksum="8AB887B02797BC2C" modified="2016-04-13" version="1">MLRLVMNPTVKSHVLKLCRAYVMPCYHHSHLTMNVMVGRSGRVSIPMRGVTCSSPVMLSINSLCRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0S3I7</accession>
    <name>A0A0E0S3I7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="3" type="primary">FG03293.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T12519</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0S3I7"/>
    <dbReference type="STRING" id="229533.A0A0E0S3I7"/>
    <dbReference type="EnsemblFungi" id="CEF78062">
        <property type="protein sequence ID" value="CEF78062"/>
        <property type="gene ID" value="FGRRES_16297"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12519"/>
    <dbReference type="eggNOG" id="KOG2741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0S3I7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43054">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43054:SF1">
        <property type="entry name" value="SCYLLO-INOSITOL 2-DEHYDROGENASE (NADP(+)) IOLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF78062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="361" mass="40391" checksum="17393371D93790C9" modified="2016-04-13" version="1">MSAPLGLAVIGTNWITNSFIQSCHESKLFQLRAVYSRKLDTAKSFIVDTPSIEDDSFVAACDNLDNMLNSQGIDVVYIASPNSLHYEQGIKTLNAGKHVIMEKPFASNMHELEELYELADSKDLFILEAYRHIQEPNFKTLQKLFDDENTRDEMFGKIYGASLSMAVYSPLFGDMTETNVPNVASPKFSGGCLMDMGVYPVTFSIRLFGVPASQTYFPVILETGVDGGGLIVFEYTPETSKHKQRFTLQARTSKLYDSHAPTEIYCEKGTIRIEGGQASNVTDICTMEFIPRGSKDGEELGDKRPKYTNMLNLTWEAKELGRIINEGDREAEGDLRALSKSVLTVVEDMRKKNGIVFDCER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0E0S5D2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromosome 2, complete genome</fullName>
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    <gene>
        <name evidence="12" type="primary">FG03830.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T13809</name>
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    <organism evidence="12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="CEF78707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0S5D2"/>
    <dbReference type="EnsemblFungi" id="CEF78707">
        <property type="protein sequence ID" value="CEF78707"/>
        <property type="gene ID" value="FGRRES_17622"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13809"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0S5D2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="MFS quinate transporter QutD"/>
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        <property type="entry name" value="MFS_sugar_transport-like"/>
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        <property type="entry name" value="MFS_Sugar_Transporters"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="Sugar/inositol_transpt"/>
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        <property type="entry name" value="Sugar_transporter_CS"/>
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        <property type="entry name" value="SP"/>
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    </dbReference>
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        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06960)-RELATED"/>
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        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
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            <begin position="28"/>
            <end position="55"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="75"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="448"/>
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            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="31"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF78707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="532" mass="58532" checksum="C7A35D2987CC35EE" modified="2016-04-13" version="1">MTIHGMFKRIVRNDAIRVDPPEIYNWRVIALTASACFAGALFGVDAGIIGGVLAMPDFQREFGLNNRSDQARADLAGNLVTTMQAGAIGGALLSSPFADRKGRKPALLLVAITGFIGGIMQAFSYGHLSAFYIGRFIEGLGLGAGTMLAPTYVSENSPRAIRGFLVGFFQLLLVLGGMTAYFINYGSLLHLPGKATWMVPLGCQSICPALLFISMIFCPESPRWLASRDQWEKAGAVLSDVRKLPVDHAYIQQELLELKTQIDQEKAVMQDTGFWALQKECWTLPWNRKRALLTVGIVTLGQWTGTGAINYYAPTIFKDLGLSSTTTALFAQGIYGVVKVVTCLIFIFFLADSLGRRKSFMIGGAIQAFCMFFIGFYLRFGPEPGENDHPPPAGIAALAMVYIFAAAFNMSWGPVSWIYVSEIPTNRLRAYNVALASFTHWVHNLAVSKSTPVMLLHDPYRAYFIFGSFNFCMAVVAYWIPETKGISLERMDEVFGIADFSKVEDVGIAASRAKRIDDENVEDVQTDRPVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0S7B4</accession>
    <name>A0A0E0S7B4_GIBZE</name>
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        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T15177</name>
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    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0S7B4"/>
    <dbReference type="EnsemblFungi" id="CEF79389">
        <property type="protein sequence ID" value="CEF79389"/>
        <property type="gene ID" value="FGRRES_15241"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15177"/>
    <dbReference type="InParanoid" id="A0A0E0S7B4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
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        <source>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SAQ5"/>
    <dbReference type="EnsemblFungi" id="CEF83518">
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        <property type="gene ID" value="FGRRES_13045_6_M"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23797"/>
    <dbReference type="eggNOG" id="ENOG502RNYZ">
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
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    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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        <property type="entry name" value="DUF7614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7611" evidence="2">
        <location>
            <begin position="575"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7612" evidence="3">
        <location>
            <begin position="732"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7613" evidence="4">
        <location>
            <begin position="868"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7614" evidence="5">
        <location>
            <begin position="1023"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF84038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1165" mass="128521" checksum="3A08394E07196745" modified="2016-04-13" version="1">MENDIPAIQAPDGRSSRRDRLMGKLFGAKDRKGDEARSAANVESFLHSSSDNLTIINPPPPPPPSSLPKLAKLDTTSISRYPQALAVNHAAQQNRPLVASPARPDTNKSPGRSPRPNKKGLVVRFDDTAPDVIGEGGDESEIPTQEISKRKASRPKPQQAPQAPQPPAHRRAPMPPARPPRPDSTGPASPVDDFRPKSLSRTQTGFSSIYTPGSDDESDAGANNNLKPDELVSPISAQQTLSPARARFLGPAGRQDDNRKSYIEIHSAQQREAEGRVFAEAARVASATSASSHNWDDPHSATPLSTSPVESRRPGPPSPEVQSAKPSLEYSPAASVHSNSSAYSPPVPSAAIPASAPGASPAPIPSGSPAVPSPVPTPASAISMASTTTSEVNQLSRQPSIAPQRAPPMMASRALSVRVADGTSAAAEQALEIFTTRTSHLFELFRLHAESIKPLSTCSLMDFGRGALWWFLKGRMGLEVAIRERPSSPQGQMQNDRDRQQAYANLAKAFWLSEQVVPEVAQSQGVEIDSEITDVSASLVSALKKLAMSMKRNGFLPPEDAFLPQSIDKSIWVEYPPLSQDMIALLSGNWASGLTAMTSPMSKLRLLDALPVGDTTDNFNYGRVQADAYLMEQGHEDQKLYFPCLLSMVRPQKSTGLVFILASQNGHVQLVIQENKNVGPVWDDVRWRKETFTVDIRLRRGFMITIQLVQQDFRTLWNMYDFGSKVNQSLYPRNDESMVFRSTLRSFQVMDADPNYRQFPKEPTPYCEISLFEKIHKENGPAATRTWHLGFRIAVVTGPKTRTLSGVQHVYSPAHPVQFGFFRGDGDAPSLAIKYENGKSKGRMVMVFSDDKARIKFHSILTGTALDHDEKIYADVPLKNFSVAQSLREPLGMAPFSRMPWKAVRVVNDEFGGDMPPTVLADHLKVVIDYQNGNVADRINVAPGELRVRLEVSNAKVLRVLRQPQKDMTISVSEAQVPKELPRNMSDALQLLRHNQTIRTFEFNNLKDLHDFQLAITGFEVIFDALAVTFAIQRRRMVVPIHKKWEAGYTRIQVIRNEDGQLQLLAFFEDFHHGHCMNFQLKGTDVYEGVQRSSKSGIKFIDAKFPLPRLPADKDGDYDDMAFVCLDLPDLPGEHDDISILFENESDREALAQCLPAPIKGSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SDW8</accession>
    <name>A0A0E0SDW8_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG07089.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T23933</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SDW8"/>
    <dbReference type="SMR" id="A0A0E0SDW8"/>
    <dbReference type="STRING" id="229533.A0A0E0SDW8"/>
    <dbReference type="EnsemblFungi" id="CEF84631">
        <property type="protein sequence ID" value="CEF84631"/>
        <property type="gene ID" value="FGRRES_15028"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23933"/>
    <dbReference type="InParanoid" id="A0A0E0SDW8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF84631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="78" mass="8850" checksum="8C9CCA650D0759E9" modified="2016-04-13" version="1">MHPHLHTKNALACEEVIAALEQCHAQGFMHKAVGSCNTAKERVNECLKIERSKMQAENRNAARAKRDKIKEQQRELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SMW1</accession>
    <name>A0A0E0SMW1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="11">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="11">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="11">PHB:PPT</shortName>
            <shortName evidence="11">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG10732.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T20327</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Mitochondrion inner membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
            <orientation evidence="2 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="11"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SMW1"/>
    <dbReference type="FunCoup" id="A0A0E0SMW1">
        <property type="interactions" value="382"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A0E0SMW1"/>
    <dbReference type="EnsemblFungi" id="CEF87774">
        <property type="protein sequence ID" value="CEF87774"/>
        <property type="gene ID" value="FGRRES_17527"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20327"/>
    <dbReference type="eggNOG" id="KOG1381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0SMW1"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF87774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="404" mass="43357" checksum="237BBE230E409FEE" modified="2016-04-13" version="1">MRLNALPRASAWAQCRGISGQALRVHRQLPARPSLVHVSKALGQPWHNTQRAVAFHEAKPHSSTVATQDLDSPTATTAPAPYKPPETGLLSKLPASWVPYAELIRLDKPAGTYYLFFPCLFSTLMAAPMAMPMTSPGSVIGTSLLFFSGALIMRGAGCTINDLWDRNLDPHVSRTRLRPIARGAITPFKGLVFTGCQLLTGLGILLQFPLPCLFYGVPSLILVASYPLAKRVTYYPQAVLGLTFSWGAIMGFPALGIDLLSHTPALTAAACLYASNIAWTVLYDMIYAHMDIKDDVKAGIKSIALKHDAETKQVLTGLAAAQISLLAAAGYAAGAGPAFFIGSCGGAMVTLGLMIKRVNLKDVKDCWWWFINGCWITGGVVSLGLGADYAIRYAEASKEDNSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SNH8</accession>
    <name>A0A0E0SNH8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG05461.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T17967</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SNH8"/>
    <dbReference type="STRING" id="229533.A0A0E0SNH8"/>
    <dbReference type="EnsemblFungi" id="CEF87991">
        <property type="protein sequence ID" value="CEF87991"/>
        <property type="gene ID" value="FGRRES_16488"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17967"/>
    <dbReference type="eggNOG" id="ENOG502S6GP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0SNH8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056004">
        <property type="entry name" value="DUF7582"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24483">
        <property type="entry name" value="DUF7582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7582" evidence="2">
        <location>
            <begin position="159"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF87991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="495" mass="53755" checksum="09097218F3CB2AE0" modified="2016-04-13" version="1">MSLKDRISSPLEAGTSILDAHHLPPNMAPALEHASSCLARKSQHITLVVARRDYQLPSVVPPKGLLTPITPTTLSPGFRLNLSQGPVSRLKSLMKKGSSASLRSMDSPRSGLSSPGQVPPLELSSPRFKWPLSPSTPLSPPPMTPCTASSTTTDTMSSMMNASSGFGMRLIHTNELNPKSEKILNTILTKTEKKFALGSEWLSPAVRPSSCGLTNQLIHSSIIQNEVLFCSEGLTVLSLDRLYSLKSALSSYSKTKSPLRLEDAVDELRRIILATNGTKVSKTAILRSYDWLSVSNSALVDLDRMYRRAYGGPEQHGGIAGLTSFAEPAIKPISDSQERHIEEEASEPTINIIADKGKTPSPKPLLKLQTNFTPGPLLRPKPKKIEAPAQVPIQVDTVEEEDGDRTARPTDQLYFTMQQWEPPSTIDQILTAGPVNRSAFSPLTPTPIMSPGSPGFGPMTPHDYDDISPTTRGEWGFMLADNAFQSGRKVGVETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SQV5</accession>
    <name>A0A0E0SQV5_GIBZE</name>
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        <submittedName>
            <fullName evidence="8">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG05110.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T17123</name>
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    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SQV5"/>
    <dbReference type="STRING" id="229533.A0A0E0SQV5"/>
    <dbReference type="EnsemblFungi" id="CEF88818">
        <property type="protein sequence ID" value="CEF88818"/>
        <property type="gene ID" value="FGRRES_16456"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17123"/>
    <dbReference type="eggNOG" id="ENOG502QUQ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0SQV5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000010">
        <property type="entry name" value="GRF zinc finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="259"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="7">
        <location>
            <begin position="385"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF88818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="443" mass="50246" checksum="FA0BA24284ADC0FD" modified="2016-04-13" version="1">MKAFLTRTKRKASPEPQTENAEPDEPTEVKLALLSSLHPQHDQEYLLDILLAHDGSVSEASASLKVQIPMKKGPRVVGHQQSLKQFTSTSDSSSLTNTPTKKKLKSKAGSTLHLYDPEDVAEHTPCTIIHNFLPPEDANRLLEELLEESKTFEKITFQLFENVVSSPHTSSFYVESYDEIQRQKTEYHYNGGRLTVNTHSRIVTQCLINQMQDVRRITPQLVSVKPKVQEAVNAEIQNRIKTRYPGGKKLKYQSPNPWVPNSAFVNAYTGPQQNVGWHSDHLTYLGPRPVIGSISLGVAREFRVRRILPKDDSKTVQDQDAEGQIAIHLPHNSLLVMHAEMQEEWKHSIAPALSIDPHPISGTTRINITYRDYRANMHPKLTPRCHCGLPCVLRAVTKKKDTFGRYFWMCYANSPGQENCGFFQWAEFDDDGNPQFKKQLGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YI43</accession>
    <name>A0A1C3YI43_GIBZE</name>
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        <recommendedName>
            <fullName evidence="4 12">Endopolyphosphatase</fullName>
            <ecNumber evidence="3 12">3.6.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FGRAMPH1_01T02855</name>
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    <organism evidence="16 17">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[phosphate](n+1) + n H2O = (n+1) phosphate + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22452"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endopolyphosphatase PPN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.10" evidence="3 12"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YI43"/>
    <dbReference type="FunCoup" id="A0A1C3YI43">
        <property type="interactions" value="205"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YI43"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02855"/>
    <dbReference type="eggNOG" id="KOG3770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YI43"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Endopolyphosphatase"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012358">
        <property type="entry name" value="EndopolyPtase_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF55">
        <property type="entry name" value="ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027093">
        <property type="entry name" value="EndopolyPtase_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008687575" description="Endopolyphosphatase" evidence="14">
        <location>
            <begin position="22"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="15">
        <location>
            <begin position="98"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="369"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="481"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="633"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="392"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="490"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="635"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="674"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014458"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR027093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SCB64192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="712" mass="81897" checksum="08EE9D02FCB55D90" modified="2016-11-02" version="1">MTPTGARLLVAAALLFPSVSPSPIFDAGQKVLDAITGARDSSTTTPHVQQSSHFHPDEFYKAHASTAQGIACHRGEGPAGIYGAETTDCDSPLELVNSTLDWIRNHVKDDIDFVVWTGDTARHDSDEKRPRSASQVLEMNRRVAKKVVKTFSDDGVLTIPVIPTFGNNDFLPHNIFYAGPNKWLQSYSSIWRRFIPEQQRHSFGFGGWFEVEVIPNKLSVLSLNTMYFFDRNAGVDGCAIPSEPGFKHMEWLSVQLQRLRDRGMKAILVGHVPPARTRNKQNWDETCWQKYTLWLKQYRDVVTGAVYGHMNIDHFLFQDTKDIDLGLYDKADIYREPIEEDFSIESKSDYLMDLRKSWSNLPGEAAKAMGEDLNDDDDDIYTQDDEVDDMRNRKKGKGKKGKKKKGHGNIGGKYGERYQVSLVSPSVVPNYLPTIRIIEYDITGLENTPVWTDSFDVRTEAEEEVLPSFFEEEDNETHLELKRDFEAERRHRKNRSRKSRKGNKGRKGRKGKKRPKNPELVVPEDPPKGSLPGPAYSRQPFTFLGYTQYFANLTYINNDMTDLTETSKWRDGDFSDEVPSHDKPRPKKFNYEVEYSTFTDKIFKLPDLTVRSYLRLASRIAKRKEKKGKGKLVEEYNEDFEDDSDDDDDVSDLPEYDDDNDDEEPESDFDSTRKGKKKNNKRRKSNKVWKHFLREAFVSTIPEKKLKKWSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YIH6</accession>
    <name>A0A1C3YIH6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T05415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YIH6"/>
    <dbReference type="STRING" id="229533.A0A1C3YIH6"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05415"/>
    <dbReference type="eggNOG" id="ENOG502TDPI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YIH6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="168"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="323" mass="37749" checksum="32B69753E37B2931" modified="2016-11-02" version="1">MQGVGPSWESFCDSLDRHCPICWVSWHHIRDSPTTSYHDQVHQGFFLWYDNSSHYTNDSGLLELKCSLEIKDSQIIYVAYNKTTKQEFEDQVAKTLLEEHTGSETTLNTVKGWLSKCDEGHSKSHACIVKMRALNYPTVPTRLIDVHGHDSKTWSLIETKKNQSFSKYVALSHRWTDDTPRLLRDNCISFQTGQHDKDVPRNYQDVFVLCRKLDIRYVWIDSLCIVQDSADDFLREASTMTEVYANAFCTFSICWESPDGFLRPRDTRTIPRDGPFSSTWKCFLDQYVFVQDQNELLYPDRRHWTYPVSSSKLNTWNLKVLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJ04</accession>
    <name>A0A1C3YJ04_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T07281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJ04"/>
    <dbReference type="STRING" id="229533.A0A1C3YJ04"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07281"/>
    <dbReference type="eggNOG" id="ENOG502S2CI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJ04"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019120">
        <property type="term" value="F:hydrolase activity, acting on acid halide bonds, in C-halide compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01428">
        <property type="entry name" value="HAD_type_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB64553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="253" mass="27918" checksum="22B088F7EF17A7EA" modified="2016-11-02" version="1">MIKYHTPSKMGQTVIAFDLYGTILSTESIAGELAKLYGQDKAQSIASLARRYQLEYTWRANSMGTYRSFSDLTRWSFRQATKEIGLELTPEQEEHVMNAYNGLDTFPDVDDALKRLAESPSIDSYIFSNGTADMIASSLKTSPSLSQASNVFTQEKLVSIDSIQVFKPDPRTYKFMAKTAGLESQLDEVWLVSSNPFDVVGATAVGLKSVWIDRGRKGWSDGLAGSLDVKPTVIAATVDEAVQTILRQSESSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJ60</accession>
    <name>A0A1C3YJ60_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FGRAMPH1_01T06275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJ60"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06275"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJ60"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="60"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="227"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SCB64461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="395" mass="43948" checksum="1152979930F07C91" modified="2016-11-02" version="1">MAPSEIIKRMQDAAAAYDREELGARATLLNLNRQLLAELETPSDFVQRIWFTTASLGGSLEVANNTKIFQHLQKAKDGLTSQALSEKTGIAVPLLNRFMRHFAAHKVVRFSKPTGWHATDLSNTLAKENHQHSISFCQRAAAKSFCFFPDHFKQANYQHPGLPDGPYQYAHNSSLPFFDWLVANPPYVNWFGSFMSVYRAGNPDWWEFYPVEERLATGFDKSKSDVLVVDVGGGRGHDLLSFSNGIKSPGRLILQDLPEVIADVTETTAFESQAYDFFTPQPVHGARSYFLHSILHDWGTEHGVEIVKSLKPALTPGYSKVLINEIVLSEENPSLPATSMDMMMLGHIGEACERTEEDFRAIAAEAGLEVIGIFSNAASPESVIELMLPSKEDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKA7</accession>
    <name>A0A1C3YKA7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T21011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKA7"/>
    <dbReference type="STRING" id="229533.A0A1C3YKA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21011"/>
    <dbReference type="eggNOG" id="ENOG502SJ66">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YKA7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="504"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB64989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="742" mass="84790" checksum="00C5BB72404237E9" modified="2016-11-02" version="1">MILTVLTEKPAVQRNMLGEPQNDAPSHRLMVDECRSYKRKFDSIKTRDPHLKEKQESEWEYYVGIASKNVAQWEEKRSSLCAAARYWGTERLQYYEWFAQTKHFCKKLAVAAKRVPNWEEAVIKLNQIRLNRHHAVGKQRITADGPEIRCWDLDMLKSWINKSPYGIKRKENIDQLEFRPVYRQELESHGLDKYGLLVAQGSRIEVPLPNYPATAPPRPSIPSKRQISDSLGSQNNIDRNPKRQQQQIAPDKQTKQISGHEHVRPVHNTEGISHTSLSPLRAESTRSSIQSHFEELLSPISDTNDVPLSPSLSPDISNEGNDEDNDEGNGEGNDELETGPIQDSLSIEITQFPTQWSGDDSEAALFLEDVRRELQLRPKRSKQSRTWGDDTVKSLRSLLSCIQSPNINPANGPIEIHLLSSEEAQRRVETGSSDIPIIVDGDQSFLWDPSPRVIQQLFNNGWIVNLDRQVSVQIPSLPTTGASCELKSLREVKTRFLKNIPHDEPWNLLNLSNPLPPSVLPRFLAGPNCQLIQRVREWLVNYDSAERESLDLRKMKKWHAVTEWALLSEGGHNTGSHMDSHGMGTWITVQEGRIGFGYISPDRNFNWAAWRNDHSYHGHRARYVVLKAGQTVYFPPGTIHFVFRSRKEQTFAIGGHVLQWSNILRFLHVLKEQETDDTVTNEDVTTASGAFWRDPIMGLVQERIKEGAVEMLGGLEVANRIMDILKNWEDCDLKMEDVFDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKC0</accession>
    <name>A0A1C3YKC0_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FGRAMPH1_01T20855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        <property type="component" value="Chromosome 3"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:mRNA binding"/>
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        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SCB64976.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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    </evidence>
    <sequence length="150" mass="16945" checksum="BBD070921B81C051" modified="2016-11-02" version="1">MALALPLTHQTFEKWIALIVNAFLTNAHSTTVKMVKKRKNNGRNKKGRGHVKPIRCSNCSRCTPKDKAIKRFTIRNMVESAAIRDISDASVFAEYTVPKMYLKLQYCVSCAIHGKIVRVRSVVGRRNRAPPPRVRYNKDGKKIVPTAPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKI4</accession>
    <name>A0A1C3YKI4_GIBZE</name>
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            <fullName evidence="10">Chromosome 3, complete genome</fullName>
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    <gene>
        <name evidence="10" type="ORF">FGRAMPH1_01T19823</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970334">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="229533.A0A1C3YKI4"/>
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    <dbReference type="eggNOG" id="ENOG502S8M1">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A1C3YKI4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="InterPro" id="IPR028020">
        <property type="entry name" value="ASX_DEUBAD_dom"/>
    </dbReference>
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        <property type="entry name" value="DEUBAD_dom"/>
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    <dbReference type="Pfam" id="PF13919">
        <property type="entry name" value="ASXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
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    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEUBAD" evidence="9">
        <location>
            <begin position="162"/>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SCB64891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="373" mass="41310" checksum="10DACA4E814F9F17" modified="2016-11-02" version="1">MCNARFVSRYVQLRQERLCRATYKLLATKVPRIEATLEPGQTNSNPDRASALTNLDQPNSLATMAYDDRDTIVVSGEDAIEPQENVSEYSLPLSVPDQGLDDGSHPIVDQLPDASASPLAQQETSTASTSKGIKKAKSKKRVVVKKAARRSKWNQDNILTDPKSPLASADLRSILSNPMAWEILENEERAEILALFPDSQHILSAGTEDACPDFASLMNDDSFRYDCAAYTENIAQGRHDPEWLAQAWAAHERRKMGDFDEHLDNKFKDDWDVNLPPELKTTRSPIVSKEENDVKMEGTEHMANGNEDQAEASMTNGTDTLNEQNPELGKDARVNELPRDDAAQEISLYIATGHQSPAMEIDGEGTTNEPVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T23803</name>
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    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKV4"/>
    <dbReference type="STRING" id="229533.A0A1C3YKV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23803"/>
    <dbReference type="eggNOG" id="ENOG502S5P0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YKV4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB65170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="365" mass="41377" checksum="F1B151C5CA14D7D8" modified="2016-11-02" version="1">MPKRSLDVANMGGPNAKPAPARKTERSHEENQERAYIAASRRADRSIEARVQSAKMASEIHKKRTGKAFRITEEIVMKEEMYEEEDDDFPRSYRLLKSNMQTPNAEFNARVDAYLTNRVAMSQLLSATEADWRNNEINQTFAQFFPQAQRQAQSMSHRWSTPGYSVPQPQNNHVSSPMEQHFDPNFQTVNYAPHQPTRHNERNHSMSGLSPTESRNDGPVSPPALTPGSGTHPETPQSRCASTFGNVQPPPVMDFSHDGSAFTTELPAEAKMLLGGVGMNDFNPTLYGEHQNWGAQQPFHYGEDTKYFKEEDSELDTGYGKYPDPDTMNWDDANFATPTKYSTDEQEPSWDSYINDTAWVTEQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLU4</accession>
    <name>A0A1C3YLU4_GIBZE</name>
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        <submittedName>
            <fullName evidence="8">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T27889</name>
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    <organism evidence="8 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YLU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27889"/>
    <dbReference type="eggNOG" id="ENOG502T4GS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YLU4"/>
    <dbReference type="PHI-base" id="PHI:5891"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Peptidases_S8_S53"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
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    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SUBTILISIN"/>
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        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
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            <begin position="389"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="560"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="299"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
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            <position position="395"/>
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    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00082"/>
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    </evidence>
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            <dbReference type="EMBL" id="SCB65512.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="697" mass="76953" checksum="B06D78D7C7C791EB" modified="2016-11-02" version="1">MQDTDYREKLKKLLTQIEVCIKFNVPGWAAAELHHASLLWQVPAFDGDGFVIDQLAILNRNWSLRIMIKSSLHSTDDIWNHKDVKTWMSTSKSTILFVVGNSQSLKRLERFSVEVIMRLKDEPVIHLLDPLPNSLPDPFKLSTVNVLRQLAIQCLQRLSTPKTLGFLVKLNLDFRSASESDWYRLLAELMKHQPRVSIVLDLAIMGSNLREAHSLETVFSQIIQLLQDKTCLRVMILTGRPMDIDLNSVATKMIVGPLPSSRYTPTDVLRLVRSPIGQQSSSKVFITRDRELLDPPGHPSSSVPVKQSTSSSTNVEETTAQQADNTGSCNTDATPMRRLEDSFKNLSMGSLQSSGSDSSTRSTEQWFQMLGATTHEFMYKQEFKSTTPVKIAVLDTGFAYNNPQDKRSLRPYYQRIKRLANFIEGDPDSEAKTDPSGHGTAVAVQILKVSLTAVLYICRVAGPDGVPDKSAIERAIQKASAKPDKESPDGGGWGVDIINMSFGWPYHHGGVRNAIEFARQNGVHLFASTSNDGLLGPPNDILYPARSDSVMAVDAADGLGEHARSAPSSSSQHSRGSRFSAPGLGITSPNTDHIWEGSSFACPIAVGVAALILEFARQIPLNKSPEVQTYLQEMPAMLAMLRRASSEKGPDGLKFLTPWKLIGKAGEDRLVTAWFIVDELRKEYGLEVGADVLPNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLU8</accession>
    <name>A0A1C3YLU8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T26841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YLU8"/>
    <dbReference type="STRING" id="229533.A0A1C3YLU8"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26841"/>
    <dbReference type="eggNOG" id="KOG1618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YLU8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF57">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SCB65414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="501" mass="56224" checksum="A57A74CF57BF8EEA" modified="2016-11-02" version="1">MQRFGVVGQCRFAARRLTQPRYVAPLAATALRASCLSQRTFHTSHTALSKPKGSLGVNPNNFEEPTDLARKIFSEFAFAFDIDGVLYQGRDRVDGADKVIKMLRSNGIRYVFLTNGGCVPESKKEESLQERLQIPKHEDAIKGRMILSHTPMSGWSEDIKNDGTILITGSHPEKARQIALDYGFKRVVTPADILAECGDVFPFEHIEGEINGKPVPLPDGKRIPLLKDPYSTNIPANALKIDHIFIWNDPRDWSVDIQLIHDLLISHQGYLGTVSNLNGNEKLPNNGWQQDGQPGLWISNLDLLWKTNYPVNRFGTGAFMEALKGVWSTTTNGKELEYSALGKPSNHTYRYAHERLLQYYHDMACNRGQSPGHDKSKYHPLRRVYMIGDNPESDIRGASEFEAEDGTEWVPILVRTGVWRQTATEKEPRYKPVVIVDDVVDALVWALNNEGIKADREWVLSALSHTKGYVKLPPLEDGVHNGDLEVGAKYPSELEATEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YM34</accession>
    <name>A0A1C3YM34_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FGRAMPH1_01T09527</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YM34"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09527"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YM34"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
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        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="138"/>
            <end position="158"/>
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="178"/>
            <end position="201"/>
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="269"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SCB65576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="620" mass="69465" checksum="7A6EFC7DA38F647F" modified="2016-11-02" version="1">MDIFKRHGDHGHEEKKHGHGHQTEDGARQHFLACLYWYVLATLLIIASVSHFVSLFVAKQRLKRRDLGASSDTAISTIEKFIDTPKNLTSRLVGHPAWSATLPVRKTIVVVAYAAFIALLITYKSIKRDGTFHERIAFRAAWITATQTSLPFLLAVRVNPIGLLLGTSYERINWFHRWASRVFFASATIHGGFFTYEWLAASFFWTEIKTVKMVLPGIAAWFILAWTVISTIPFFRRIKYELFVVQHIISVVLLLVFLVLHVPDHHLFSIWCAVGVFAYDVVTRSANPIWRNLRLRVSANPSVRYAHDAQVEAVDSELTVMTVRNVGFKWIPGQHVLIWSPTFRWETPHPFTITNIPDSQTKTQDLQLTIKTKTGLTRDLNDWARRTGLRGDTGGLRVMVTGPFGAVPNWKQYENLVLVAASTGGSFTTPILEDLLSSQSPGCIRTISALYIVRHTAHAKVYLQRITRLLSRAKEMGISTKIQVAVTRGPNTVSEGVLQDESRERLIDPETARGPSVELERFSIDSARSSESAKEDQLLKEEVDMDLDGAYASAIEHTDGRPEIATFIRTAVGDVPGNVAVAVCGGEAIERAVKMSVATLRRRSGMDAGDVYLHVERSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMQ0</accession>
    <name>A0A1C3YMQ0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FGRAMPH1_01T12553</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YMQ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12553"/>
    <dbReference type="eggNOG" id="ENOG502RYG3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YMQ0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="4">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SCB65791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="135" mass="14889" checksum="4C78DA9767F81969" modified="2016-11-02" version="1">MPRMNLGLPYNHCSLASGCRVGFQSPNLLRCGACQVVKYCGKPHQKAKLRAEPGEDTGGENPFDTAVGQFWYFRSTRPYMSVSFDLMSAILSVRTGEAVQAAPDHALDMIRLCRGDNQGVRSYVPALHLRLGNDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1R9J7</accession>
    <accession>A0A098D0Q8</accession>
    <name>I1R9J7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG00140.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T00381</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF71990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315743.1">
        <property type="nucleotide sequence ID" value="XM_011317441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1R9J7"/>
    <dbReference type="EnsemblFungi" id="CEF71990">
        <property type="protein sequence ID" value="CEF71990"/>
        <property type="gene ID" value="FGRRES_00140"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00140"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00381"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014021_0_0_1"/>
    <dbReference type="InParanoid" id="I1R9J7"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="658"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="842"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="337"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF71990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF71990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1062" mass="115103" checksum="3B956F328CC2B26B" modified="2012-06-13" version="1">MTTQIAPLGPAPAIPATDKEYSFFEALALGPRESFSLVSNEALGLPSSPTSPTRPTAISEQQQQKSRSPLPSSLPELTPSGRPATPPHTKKRLAQVSAQAYVPASPSRSATVLPTPKSATAPPSSSLKQAPSVTTSSVPNSTAPRSLNSKKSVVMANTVKAQSACLELCHKTTALGDRISVRMLEYLTMVTKQPHGLDVLAHDFLDTCEILFSIEAGLGECIRNQQTFPADVISELSKKFRVTQADFQLLDQMLGRFLENERKGTMGRMRRGWGRIFGDNDIEKMISALGRTRESLRMSALMFQWSLGNEKIENELGIGYTGLAAALDRMDSRAGVAPRSKVSDAGGSQYRPSSASAHRGMEGHQMSINSQPPLPPLPWAGGGTASLHTDNIAASLHNDARSFSGHHPNGASSVHSNERYHSGTTATFDRMSTFDEHHETRSQHTQISDSEVSLEELAGLDLNGGTKAVRIKADPFSMPRWNPRNTVGADAANLKTALISAVRGKNHKLIEQLLDRGVSPNTGPDHLALKEAVLNTDSEAVRLLLLFGADPNGIDRDGITPLFAAVERSFIAGAVPLLKYGADPRFQIGPDNETALAAACMANKVNFAHLLLIYGGDPNQLTASGETLLSSAINKKTPKRFIDLILDYGANPDGKSREGKTALFEAIQNSRVDIVQSLLDHGADPNLPGPKHMLWPSTYQSACLQVLLNHGADPKKAPGIMELAVSVNNIESVRILLNAKVDPNLKKDGVYTPLCTSIRDNRPDIFHLLLANKADPNVPASEYPAFKCITHNRLQYLPRLVEAGANLSSPKGIVETAVSVNNMEALTWLLEKGMNPNDKNPKGHSPLTTAIRENRIEMVDYLLTNGADPNVRGQDWPVCMAVRNPPILKRILSVLAEPRAFKGVMEMAVVANQLESVKLLINAGVSVEDKNGGVFSPLTSAIREDRKDIVWYLINEGGADINAPGEHLPVVKALRRYRGDGEILEFLLEHGADPNKVYRGWNGVMQAVENGDEAILRLLGEKAGFDLDVKDELERSVTEIAASRGWEEAVEILQQYAITKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1RA03</accession>
    <name>I1RA03_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG00320.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T00847</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315969.1">
        <property type="nucleotide sequence ID" value="XM_011317667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RA03"/>
    <dbReference type="STRING" id="229533.I1RA03"/>
    <dbReference type="EnsemblFungi" id="CEF72226">
        <property type="protein sequence ID" value="CEF72226"/>
        <property type="gene ID" value="FGRRES_00320"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00320"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00847"/>
    <dbReference type="eggNOG" id="KOG2741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_7_2_1"/>
    <dbReference type="InParanoid" id="I1RA03"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF115">
        <property type="entry name" value="DIHYDRODIOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="13"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="147"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF72226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="391" mass="42823" checksum="23D66E179167B3C5" modified="2012-06-13" version="1">MAPYIAKWGILATGGIAECFTKDLLTDPATREVDDVQHEIVAVASSSSVDRARDFIKKIDGPSSAAVYGSYAELVADPNVNIIYVATPHSHHFQNAMLALEAGKNVLCEKALTVTVAQTKKLYEVAKSKNLFFMEAVWTRYFPLSIKVRELIQSGVIGNVYRTFADLSFNKNTNSDDLEFPDSNRMVNPDLAGGALLDLGIYSLTWVFQSLYHVQPEADKEAPNVVASINKYRTGADESTSIICQFPKHRSVGIATTSLRIATDVDGHYTGGPAIRIQGSKGEIQVTGPAYRPTEYKVIKSDANGNVEVVTCPIPTDPKRNNWGHGMFWEADECARCLRDGKKESASMPWSESIAIMEVMDSALKQGGVTYPELITTDVFDANSPLNTGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RA63</accession>
    <name>I1RA63_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG00388.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T01015</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316050.1">
        <property type="nucleotide sequence ID" value="XM_011317748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RA63"/>
    <dbReference type="FunCoup" id="I1RA63">
        <property type="interactions" value="769"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RA63"/>
    <dbReference type="EnsemblFungi" id="CEF72310">
        <property type="protein sequence ID" value="CEF72310"/>
        <property type="gene ID" value="FGRRES_00388"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00388"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01015"/>
    <dbReference type="eggNOG" id="KOG3242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064761_3_1_1"/>
    <dbReference type="InParanoid" id="I1RA63"/>
    <dbReference type="OrthoDB" id="270189at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000003">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="20"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF72310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="215" mass="24622" checksum="BC3BCAEBCC64034D" modified="2012-06-13" version="1">MSTAAEGQADNQTKSACDDPLVWIDCEMTGLDQDNDEIIEIYCIITTGNLEILDEEGFHAIIHFPQSRLDQMDEWCTKTHAESGLTAAVLESTTTPEQAADALYEYITRFIPERKRGLLAGNSVHCDRAFLRREPYKRVMRHLHHRILDVSSIKEAARRWAAKRIVNKVPNKKGLHKARDDILESIEEAKYYREVIFRPTFDVVPAKNKPNKGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1RB61</accession>
    <name>I1RB61_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG00768.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T01935</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
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            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
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            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
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    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        <citation type="submission" date="2017-01" db="UniProtKB">
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                <consortium name="EnsemblFungi"/>
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            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>PH-1</strain>
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    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
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                <consortium name="EnsemblFungi"/>
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            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF72953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="92" mass="10048" checksum="7E983145AD1F6AAC" modified="2012-06-13" version="1">MSDLPPQNFLPLTPPPKSSFLSLAPATSPSYPQKPAVRSHTRPAAERRASVESSASSSSGSNNSYRILKLGPVHWGEHADDHKHDFHDIVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I1RBN9</accession>
    <accession>A0A098D225</accession>
    <name>I1RBN9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG00970.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T02435</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316712.1">
        <property type="nucleotide sequence ID" value="XM_011318410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RBN9"/>
    <dbReference type="STRING" id="229533.I1RBN9"/>
    <dbReference type="EnsemblFungi" id="CEF73019">
        <property type="protein sequence ID" value="CEF73019"/>
        <property type="gene ID" value="FGRRES_00970"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00970"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02435"/>
    <dbReference type="eggNOG" id="KOG1970">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006397_1_0_1"/>
    <dbReference type="InParanoid" id="I1RBN9"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057927">
        <property type="entry name" value="RAD24-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25812">
        <property type="entry name" value="RAD24_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Checkpoint protein RAD24-like helical bundle" evidence="9">
        <location>
            <begin position="507"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="804"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="804"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF73019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="859" mass="94577" checksum="68601742826EA798" modified="2012-06-13" version="1">MAPPAKRRRRNIVEASDDEDEQPHANTLNKFLLSLPSSPTKNRAPTASPSPTKPKILANNPAKNGSLRLPRRAHQNQRNSTSPSTKRTKDVGKAADKGKTADLRTLFSNQAQKAVKTGAGDRQSVPLDDIISDPISEDDDISEQKASSSSLVGQHAKKRLRNDSQTAFPAAPSASQKFIKPPKPIPLATANNDTRPWSERFGPKNLEEIAVNKKKVSDVRRWLEDVMAGRMRQRLLILKGAAGSGKTTTMRLLANDMGCELLEWRNPAGSSGLGFVSASAQFEEFLGRGGKFGALDTDVPTLPSSQSSSQAARKSDSKRVILIEEFPNTFAKSSTALTSFRNTILQYLANNTPSLSIFAKPSQQEPVTPVVMIISETHLTTTSASADSFTAHRLLGPEILQHPGVGMIEFNAIAPSFLLKALELIVQKEARKSGRRKTPGPQVLKRLGEIGDIRNAASSLEFLCLKGDQQGDWGNKVAFTKQTKGTKDAIKLTQGEEESLELISQREASLGIFHAVGKVVYNKRDEFAPRDDTTERLPGFLSQHSRPKRSEVSVDTLIDETGTDTHTFVSALHENYVLSCESTDPMDLSTPMDYVNDCIEYLSQADLLSPSRDIFFGGRGGFSSPDSGSHVLRQDEITFQVAVRGMLFSLPNPVKRKSSSTLKGTDAFKMFYPTSLKLWRAKEELEGFVDMWSTKLLRGDDGAIKNLTDGATAFYRPQQNSDETSWMQRKQQSRQAAIKLQQQKQKEDEIQDTPLLSLGSAARRELLLERLPYMAHIARARKTSTFRLRDLEKVVAFKGINAADEESDAEDDMSPGEAWATDKPSEEMGPRKKRAGIKDGNVSGLLAQKLVLSDDDIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1RBW3</accession>
    <name>I1RBW3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG01054.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T02637</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-K/MCM22 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316811.1">
        <property type="nucleotide sequence ID" value="XM_011318509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RBW3"/>
    <dbReference type="EnsemblFungi" id="CEF73120">
        <property type="protein sequence ID" value="CEF73120"/>
        <property type="gene ID" value="FGRRES_01054"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01054"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02637"/>
    <dbReference type="eggNOG" id="ENOG502RXW1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048926_0_0_1"/>
    <dbReference type="InParanoid" id="I1RBW3"/>
    <dbReference type="OrthoDB" id="9445768at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020993">
        <property type="entry name" value="Centromere_CenpK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401">
        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401:SF6">
        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="90"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF73120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="316" mass="35448" checksum="0E12CDFFE36CE370" modified="2012-06-13" version="1">MALQAYTVSLDQTLRELQQQVRQHEEELERLRSNELRLPESVAGQTQVIQAALKEVTESDPFLPSPGSLLPALLALRRTHQTIQESNTYLDSQRSTHEQLSRQLEADEARLKDQKLLSDALTARIQSLRDEVDASTNVTPEEGAKERLQELRTKKKTFDRDTTKLMKVLLRFIANHLAPMLAAEELGGPVVGDLMDVDGEALAAGFNAQGKLKKPKETVDKDDKRQRRIDEIWGQAPAEGSGRQNEVTAAAAEMRQLTEELLNTLSEAQGDNSASYVQLSRESAAARFLVRSKIAQFHPRDAMRLRLVDFGRDLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1RCC2</accession>
    <name>I1RCC2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG01227.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T03037</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317002.1">
        <property type="nucleotide sequence ID" value="XM_011318700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RCC2"/>
    <dbReference type="STRING" id="229533.I1RCC2"/>
    <dbReference type="EnsemblFungi" id="CEF73320">
        <property type="protein sequence ID" value="CEF73320"/>
        <property type="gene ID" value="FGRRES_01227"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01227"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03037"/>
    <dbReference type="eggNOG" id="KOG1430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045030_1_0_1"/>
    <dbReference type="InParanoid" id="I1RCC2"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF11">
        <property type="entry name" value="LD23561P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF73320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="375" mass="42317" checksum="9872930DADD63C7C" modified="2012-06-13" version="1">MAEKPSVLIIGGLGYIGRFLALHIHQNDLASDVRLVDKVLPQLAWLAPEFSEACSQDKFMQADASRPEGLARIFDRPDGKQWDYVFNCGGETRYSQEDEVYKLRSLNLSIAVGKEAAKRGVKAFFELSTGMVYKSDSSPSKEVDKLKPWNRIAVFKLQAEEELSKIEGLNLIIVRLPHVYGPYASQWVATALCMARTYQHLEDEMKWLWTKDLRTNTAHIDDVTRALWDIAAWYDAGKAKWDEASMGKVPIFNIVDEGATSQGTIATIIGDIFKIETGFQGQLISTFARLNLDSVVDDVNDELLGPWADLLADAGITRPGPLTPFMEKELLKDTDLSMDGTRLKTLLGFEYKKPTLTKELIEEVIESYKKMKWWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1RCG4</accession>
    <accession>A0A098D4K9</accession>
    <name>I1RCG4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG01278.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T03165</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317059.1">
        <property type="nucleotide sequence ID" value="XM_011318757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RCG4"/>
    <dbReference type="FunCoup" id="I1RCG4">
        <property type="interactions" value="817"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RCG4"/>
    <dbReference type="EnsemblFungi" id="CEF73385">
        <property type="protein sequence ID" value="CEF73385"/>
        <property type="gene ID" value="FGRRES_01278_M"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01278"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03165"/>
    <dbReference type="eggNOG" id="KOG0887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100745_1_0_1"/>
    <dbReference type="InParanoid" id="I1RCG4"/>
    <dbReference type="OrthoDB" id="1166329at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018266">
        <property type="entry name" value="Ribosomal_eL33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01105">
        <property type="entry name" value="RIBOSOMAL_L35AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF73385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="109" mass="12201" checksum="C176BF426446D47D" modified="2012-06-13" version="1">MPSEAGHRLYVKGRHLSYQRSRHTTRPATSLIKIEGVDDTNAANFYLGKKVAFVYRAQKEIRGTKIRVIWGKVTRPHGNSGVVRAKFTSPLPTKSFGASVRVMLYPSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1REF4</accession>
    <accession>A0A098D8I6</accession>
    <name>I1REF4_GIBZE</name>
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        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="primary">FG02042.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T04929</name>
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    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317915.1">
        <property type="nucleotide sequence ID" value="XM_011319613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1REF4"/>
    <dbReference type="EnsemblFungi" id="CEF74271">
        <property type="protein sequence ID" value="CEF74271"/>
        <property type="gene ID" value="FGRRES_02042"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02042"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04929"/>
    <dbReference type="eggNOG" id="ENOG502RMVF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_628579_0_0_1"/>
    <dbReference type="InParanoid" id="I1REF4"/>
    <dbReference type="OrthoDB" id="4923501at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF74271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="436" mass="49793" checksum="14FF3B2E2C654C36" modified="2012-06-13" version="1">MAHSTFYSPPSIKETAQSIRQQSARYSHVNQDMQSLVDQVENDPETDMFGFITQYFGPRNLPLAVAAFSIFRFPYDPLPLGSDLDSWVPKYLPTITGNPSLLNEFLQLADNINQLSAIYASMPGAQRFWEALYRRSLYQSYGDDFSHTAAWATPDLPLYYLATLNKDQIGMVFGNQDQPGESPVDSEGDPIDPELLVRVQQSFWFEELEVRARTLFEMFDYGNLPIDEEALGPIDDLLENEPSVDVVPFQRLVKWQRLVRTVHKNGVRDTRTSKKLFKILHTERFYALGAQGLVACLPSYNDSYDVSYIFELASANSRIHLFLFGNIKAGALGEWFDGWFEKYPVSDPIEHVSLDTEYSSHEEDQFAMAAYVIGLDDADVAFLWGMKNPQILAEPPVLDSFDETLLSTTMLTYDMVDIRAMWSSDPYMFDRRMHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I1RET1</accession>
    <accession>A0A098D7M1</accession>
    <name>I1RET1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG02182.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T05261</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318069.1">
        <property type="nucleotide sequence ID" value="XM_011319767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RET1"/>
    <dbReference type="EnsemblFungi" id="CEF74435">
        <property type="protein sequence ID" value="CEF74435"/>
        <property type="gene ID" value="FGRRES_02182"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02182"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05261"/>
    <dbReference type="eggNOG" id="ENOG502QQXU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016835_1_0_1"/>
    <dbReference type="InParanoid" id="I1RET1"/>
    <dbReference type="OrthoDB" id="5000017at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF74435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="306" mass="34971" checksum="7B396FBC0B0DB4B5" modified="2012-06-13" version="1">MLPLVAGTVVDSPNDPIPKKWEKALPMTWDNTEIMMTAMFPDGPGFTKYHNWALDQIMDGNGTVNVCMRWNSDKVLDEETRNNIHAQHVQQYEQWLQWLPGWDNFPFKEVKHNVIAWAVANDSQLVGNRDGFHVYTEFKDENGAPDCDPGCSRHLHQDGDFSKCGRGAENRYQQYFLVDKAWGDYNMGAASGEGITVSEYGWDHVGSQLGNWSILVHETGHTFGLRDYINDHSNTTDICSIMWLPPNLESQMVMEPTDQGAHIPMLSHYEGWLNRYLWSRFSRLRGWQEDGTTYPPTPKCPPGSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I1REV2</accession>
    <name>I1REV2_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">agmatinase</fullName>
            <ecNumber evidence="4">3.5.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG02206.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T05321</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>agmatine + H2O = urea + putrescine</text>
            <dbReference type="Rhea" id="RHEA:13929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="3.5.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="4"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318099.1">
        <property type="nucleotide sequence ID" value="XM_011319797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1REV2"/>
    <dbReference type="SMR" id="I1REV2"/>
    <dbReference type="STRING" id="229533.I1REV2"/>
    <dbReference type="EnsemblFungi" id="CEF74465">
        <property type="protein sequence ID" value="CEF74465"/>
        <property type="gene ID" value="FGRRES_02206"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02206"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05321"/>
    <dbReference type="eggNOG" id="KOG2964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_1_1_1"/>
    <dbReference type="InParanoid" id="I1REV2"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019627">
        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000006">
        <property type="entry name" value="Agmatinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF30">
        <property type="entry name" value="AGMATINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124139" description="agmatinase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00050304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00066392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF74465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="395" mass="42868" checksum="915D6B7B8C350D5B" modified="2012-06-13" version="1">MLFKSFTFLSIASVAIAHGSHDQEPMEGPHQSLWYNTLPGDGGTQADSVFSGISTFGRLPYQPCLGHNSIKYDIAFIGAPFDTGTSYRPGARFGPSGIRQGSRRLNLYGGYNVPLATNPFNSWATVLDCGDIPVTSYDNQFALQQIEEGHYSILSRPPVTDADKLGPASKGRTLPRVITLGGDHTITLPLLRSINRAYGPVTVIHFDSHLDTWRPKVFGGSPSEAASINHGTYFYHAAMEGLLVNDTNIHAGIRTTLSGPSDYDNDGYCGFEIVEAREIDTIGTTGIIEKILKRVGPDRPVYLSIDIDTLDPAFAPATGTPETGGWSTRELRTIIRGLESLNLIAADIVEVAPAYDTNAEHTTMAAADVLYEVMSIMVKKGPLSRMMDGKLQEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1RFJ3</accession>
    <name>I1RFJ3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG02471.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T05927</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318397.1">
        <property type="nucleotide sequence ID" value="XM_011320095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RFJ3"/>
    <dbReference type="STRING" id="229533.I1RFJ3"/>
    <dbReference type="EnsemblFungi" id="CEF74768">
        <property type="protein sequence ID" value="CEF74768"/>
        <property type="gene ID" value="FGRRES_02471"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02471"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05927"/>
    <dbReference type="eggNOG" id="ENOG502QTDM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013895_1_1_1"/>
    <dbReference type="InParanoid" id="I1RFJ3"/>
    <dbReference type="OrthoDB" id="1751210at2759"/>
    <dbReference type="PHI-base" id="PHI:9217"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055509">
        <property type="entry name" value="DUF7082"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463:SF1">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23305">
        <property type="entry name" value="DUF7082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7082" evidence="2">
        <location>
            <begin position="399"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF74768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="728" mass="79261" checksum="5C18AE92E9A6A243" modified="2012-06-13" version="1">MSTSKFQCPPYKLFEPDYHPQKPIIVGVDDRLESPDTIALRYEEAARAENGGGDLRGDSPPRLLEMATYTKAQLPSMHAGYDVARYQDASYEQYPAQNYPTQQQSDKFAQLNQQSFASNNAAVAYGMAPSMATPNVLSCQPPTGVFGTKVYVKLSSQYDLFLLSTPMPTWSLLFGSEKCSVQDVSRDMQDSTGFIYSCSGDAPQFLVTNCASSNVPLSLVLDGPSGEEISRVPVGTFQYLEGSGDDITRSTKMPKHEDTAPAPSMDQPSTSPKGEPQLSAESGTNTYEYPPQQGQYASAFPQANNEMISTYSRSTSFTDPHYHRRPTAGWSPYPSTLGSTGRGPSGLDASLVGRPPLTPLGMSSPSHPSGAPQLVRTSTIAANPGNNSNYHPISLYSGKAILKISGKLETMAENWTSEEWANRRRIVLFRKTQKGSTVNATCQSVSVNDRPPNSICISCIWWAEKGECYVTSVDTIYLLEQLVAAPARFSVEEKNRIRRNLEGFHPQTVSKAKPDSEEFFKIIMGFPNPKPRNIEKDVKVFPWKILESALKKIIGKYSVSPSSTVAPPSMISHPNGHYAPLPTPPGQSMAPTHPDPHTQYSLPQHHDSIPSPRSLSGSQPSWTPYTTAPPGYSAASRTLSPGLRHHSPQQPPLRINTTPLPAVSSYDSRGGYGASGLHTPLSHHPPTATPPRWDPTPATYPEGYPSLTSQTAQPVYGATSYGEPAPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RFK2</accession>
    <name>I1RFK2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG02481.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T05953</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318409.1">
        <property type="nucleotide sequence ID" value="XM_011320107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RFK2"/>
    <dbReference type="FunCoup" id="I1RFK2">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RFK2"/>
    <dbReference type="EnsemblFungi" id="CEF74781">
        <property type="protein sequence ID" value="CEF74781"/>
        <property type="gene ID" value="FGRRES_02481"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02481"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05953"/>
    <dbReference type="eggNOG" id="ENOG502QT2Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047267_0_0_1"/>
    <dbReference type="InParanoid" id="I1RFK2"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070917">
        <property type="term" value="F:inositol phosphoceramide synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006673">
        <property type="term" value="P:inositol phosphoceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013862">
        <property type="entry name" value="Kei1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08552">
        <property type="entry name" value="Kei1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF74781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="259" mass="28393" checksum="3BE9E81AA4D438DB" modified="2012-06-13" version="1">MSRLTRSLRLPRPKSLFGITSLQTGTELISLALVFNKITGVYGLLAILTGYQLSLLQLSTYVYSIAVLVGLAILTPHVRRQSPFECLALAWLYIIDTVVNAAYTAAFGLDWYFSTQLNETIESKKTDLPNFVAEGMQGLRKEAAMHGKVVPQETAASMLLIVGATLIRVYFSFVVMAYAKQVLQKYMQLMILEGPGVDDQEGPFAEDLPDGEGRRGRLGRLMVSCGRAYWLDTRESDEWAPSLGGSNKPTGAGTLSGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>I1RFZ7</accession>
    <name>I1RFZ7_GIBZE</name>
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        <submittedName>
            <fullName evidence="9">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG02645.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T06347</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318595.1">
        <property type="nucleotide sequence ID" value="XM_011320293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RFZ7"/>
    <dbReference type="STRING" id="229533.I1RFZ7"/>
    <dbReference type="EnsemblFungi" id="CEF74978">
        <property type="protein sequence ID" value="CEF74978"/>
        <property type="gene ID" value="FGRRES_02645"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02645"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06347"/>
    <dbReference type="eggNOG" id="KOG0045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006072_1_2_1"/>
    <dbReference type="InParanoid" id="I1RFZ7"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000072">
        <property type="entry name" value="Cysteine proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
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        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
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        <property type="entry name" value="CALPAIN"/>
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    <dbReference type="PANTHER" id="PTHR10183:SF379">
        <property type="entry name" value="CALPAIN-5"/>
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    <dbReference type="Pfam" id="PF00648">
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        <property type="entry name" value="CALPAIN"/>
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        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="8">
        <location>
            <begin position="140"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="670"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="787"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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        <location>
            <begin position="747"/>
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        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="797"/>
            <end position="810"/>
        </location>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
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            <dbReference type="ARBA" id="ARBA00022801"/>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF74978.1"/>
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    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF74978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="902" mass="102740" checksum="AF7CF8117C6CF473" modified="2012-06-13" version="1">MSSSSSRSSSPTRASTEDLGDRSKVTPQQVIDKFWKQFTTKNPGKATTVIPSNTYTEFAAKRGNQVTTTTCQASYEDAAATCRAKVEKIIKECRRINKKYRDPHFDIELDLKWGQNDCLRSLSNRDEFVPGEDLRPESVKRVGDIFDKPRFYIDGPTANDIRQGRNGDCWLIAALCTLSEKPGMIERLCVAHDQDVGVYGFVFYRDGEWISEIVDDFLYLIKPDYDEGYLDRVLFDDIERVDPDEAYRRIFQSNSGALYFAQCAHPQETWLPLLEKCYAKAHGDYCSIEGGFGGEGLEDLTGGITSELATTDILDKEYFWKEQLLKVNEEFLFGCSTGIFGGWGERKGIVEGHAYSIQKAVEIDGKRLLKVKNPWGKHEWTGPWSDGSKEWTAEWLQKLGHRFGDDGDFWISYEDLLRKYQAFERTRLFTPDWRVTQLWTSMSVPWALDYHDTHFSFTLSNSGPVVIALSQLDDRFFRGLEGQYRFELGFRLHKAGHSDYVVRSQTPFRMTRSVNVELELDAGDYEVRVKINATRDHEILPIENVIKNNAKSRREKLLRIGLAYDLGHCKGRFVETPEEKIARQAHEKKIKQKKRDKIRTKILKDREDSHYLLKQDFQRSEHKRLKNKERKKFKEAALKAKREARLAEKKAIKAEKAAQRALRREAKAAAKAEVEAKEKAEAEANQEEQAEKKVEEVAEKSETDAPKPEEPMTPESDNSGEQDVVEEKSAEENPAEQVTEEAKGSESDSESSSDQDTEEEVETDVESIGTLLDLADREIWIHVDNFTGEVPASDSDSSSDSESEAGDDAEKDPWNAVAVVGIRIFHKGLGEGEEDGDLNLKVIRPIRFGKDDEEVDVDKKCSTKVLDVDDSAKDATLVGDTQEKIRFIKGESPRRRTVTSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I1RG84</accession>
    <name>I1RG84_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG02740.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T06581</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318704.1">
        <property type="nucleotide sequence ID" value="XM_011320402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RG84"/>
    <dbReference type="EnsemblFungi" id="CEF75096">
        <property type="protein sequence ID" value="CEF75096"/>
        <property type="gene ID" value="FGRRES_02740"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02740"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06581"/>
    <dbReference type="HOGENOM" id="CLU_1815913_0_0_1"/>
    <dbReference type="InParanoid" id="I1RG84"/>
    <dbReference type="OrthoDB" id="4984416at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF75096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="142" mass="16495" checksum="61071DDD285FBDFC" modified="2012-06-13" version="1">MTRDTDSPDIVTLLSKCIVYLDALIRETKDPAYNLKDFPSEQEVRDVRQELNQWGITYGANRSISSTLSLDYKFRKHDYTRSTLQSQLGHLVEDLEGLQKLYKGESYQGEAKVVFGRVESVVNELIRFLGHLPKELWLELER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1RGB7</accession>
    <name>I1RGB7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG02776.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T06663</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318744.1">
        <property type="nucleotide sequence ID" value="XM_011320442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RGB7"/>
    <dbReference type="EnsemblFungi" id="CEF75137">
        <property type="protein sequence ID" value="CEF75137"/>
        <property type="gene ID" value="FGRRES_02776"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02776"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06663"/>
    <dbReference type="eggNOG" id="ENOG502RXZN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1065779_0_0_1"/>
    <dbReference type="InParanoid" id="I1RGB7"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
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    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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    </dbReference>
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        <property type="entry name" value="BTB/POZ_dom"/>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
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        <property type="entry name" value="POZ domain"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF75137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="263" mass="30214" checksum="3443FB12DCDDAA48" modified="2012-06-13" version="1">MPQPTRKRARTKAAPKEDVAEEQQSTVFTDRRTSWLVKGDEQMVELRVKAEIFHVAKSVLTKNSEYFEGCLTGRFVEAKKGIVEFQDDDIEPRYLGLYIGLAYSHSSIVPHTPPRPAQNPETMAAKTPMRDYIEVYKLCDRFLSPQMGEFIMRCIDVAIGNGHRALYRTEGDEGTQKLLMRDFADGYEVLNMQQNSQLEMGERMITYFCEGVSYRAWIDTMEELMDRPKFVAAVSRGFATKLRELQIRLKSIKRRELVGPGPV</sequence>
</entry>
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    <accession>I1RGL8</accession>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322915.1">
        <property type="nucleotide sequence ID" value="XM_011324613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RGL8"/>
    <dbReference type="EnsemblFungi" id="CEF77577">
        <property type="protein sequence ID" value="CEF77577"/>
        <property type="gene ID" value="FGRRES_02889"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02889"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11547"/>
    <dbReference type="HOGENOM" id="CLU_1619181_0_0_1"/>
    <dbReference type="InParanoid" id="I1RGL8"/>
    <dbReference type="OrthoDB" id="10596217at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF77577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="164" mass="18270" checksum="A47E6E9586F79C37" modified="2012-06-13" version="1">MCLPNSGWHAWEFLVQSLNTMEVINLAKVGQVGFTGSFASLSKLNKLAIRGLNIQWQDLSHPCSQVSVQRFENGGVTALVKPGVASTLLPVSVRKWKMESKITRKSGIKSHDRKTYIASKNSFNLNTDYLLFISPDLAEVKRFCSARWVSYQATIAVSVNTIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1RGV7</accession>
    <accession>A0A098DIA4</accession>
    <name>I1RGV7_GIBZE</name>
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        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
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    <gene>
        <name evidence="12" type="primary">FG02987.1</name>
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    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322804.1">
        <property type="nucleotide sequence ID" value="XM_011324502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RGV7"/>
    <dbReference type="ESTHER" id="gibze-q4iih1">
        <property type="family name" value="Tannase"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF77696">
        <property type="protein sequence ID" value="CEF77696"/>
        <property type="gene ID" value="FGRRES_02987"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02987"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11787"/>
    <dbReference type="eggNOG" id="ENOG502QV0G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014819_1_0_1"/>
    <dbReference type="InParanoid" id="I1RGV7"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009997658" description="Carboxylic ester hydrolase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF77696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="536" mass="57812" checksum="346FC72468703E19" modified="2012-06-13" version="1">MTPALSKVLFVLPALAVSAFAEPSSKCSAGCISIPNAIVDSVSHHTLGEAIPLPNTVPSCGGPSLKVNITSSLCRIVVNVTTSASSSTRVEAWLPDNWNSRLLATGTGGIGGCIDYRFVQNGAQLGFASFGTNTGHDGEQGFDFFLNQPEVINDFGHRGIHVEAQVAKQIVEQYYGKKASKSYYQGCSTGGRQGLQNAQLYPDDFDGILAGAPGIDWLHIVASKGILARRIGWPDLKSDTYVRPEQWQAIVAKQIEMFDPLDGVKDGVIDNPAAHAFDPAIMACGTNVLNSSLCLKPQQIASVRAAYEPLADSEGRIVYPGFNLGSDTSVFSANQVNGTADLAYKVLQDFWRGAVYNDSSWTPHNFTVKDMDFAIKLNPGGVNAAEGKLDKFYAKGGKIISYHGQADQTITPKLISEYYAKVQSNLNATLEDMHSFYRHFFIPGMYHCSGGPGAFDVGQAYPMDKDRMNAKANVLLALTKWVEDGEVPTTLVGAKYDAAGKATAYRKYCPYPYESKWDGSGNTTKADSWNCVMPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1RH16</accession>
    <accession>A0A098DH56</accession>
    <name>I1RH16_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG03052.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T11939</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322731.1">
        <property type="nucleotide sequence ID" value="XM_011324429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RH16"/>
    <dbReference type="EnsemblFungi" id="CEF77772">
        <property type="protein sequence ID" value="CEF77772"/>
        <property type="gene ID" value="FGRRES_03052"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03052"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11939"/>
    <dbReference type="eggNOG" id="ENOG502RK4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005777_0_0_1"/>
    <dbReference type="InParanoid" id="I1RH16"/>
    <dbReference type="OrthoDB" id="4798501at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045793">
        <property type="entry name" value="PcRGLX/YetA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048330">
        <property type="entry name" value="PcRGLX/YetA_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048331">
        <property type="entry name" value="PcRGLX/YetA_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048329">
        <property type="entry name" value="PcRGLX_1st"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40081">
        <property type="entry name" value="CONCANAVALIN A-LIKE LECTIN/GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40081:SF1">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19501">
        <property type="entry name" value="PcRGLX_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21345">
        <property type="entry name" value="PcRGLX_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21346">
        <property type="entry name" value="PcRGLX_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124168" evidence="2">
        <location>
            <begin position="21"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="PcRGLX/YetA-like N-terminal RIFT barrel" evidence="3">
        <location>
            <begin position="28"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="PcRGLX/YetA-like central beta-sandwich" evidence="4">
        <location>
            <begin position="130"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="PcRGLX/YetA-like C-terminal alpha/alpha toroid" evidence="5">
        <location>
            <begin position="501"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF77772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="930" mass="103114" checksum="8A53511D5E2F131F" modified="2012-06-13" version="1">MLRQAVHSFLLAALAGQTIAAPSNSSSAAKVNWLGEKPNFTSGTTFGVPWPQSKHFPKNTKFTASGASGQNIDLQSWVTGYWADGSVKWTGHAIPASEDVLDEYTIRAVAGQNGINSTSPTGSGKNTPSISVTQTSSDIKVDTGKVAAIFPKKGSVIVKEITTSDKRIAQNGRLILQSQSGVSHPSDEDSEAFKTLRFQSNIDNVTVSDQNSVRALVTVRGKHEAADKSGHDSWLPFVLRFYLYSGSESIKVIHSLVFDGDAEKDFISGVGLRFDVPLEGEELYNRHVRIAGVDGGLLSEAVQGITGLRRDPGANVRADQFDGKELPDKSTWDVRVSSRMHWIPPWNDYSLSQLSSDGFTLKKRTKSGQSWVTIPGGTRAEGLAYLGGATAGGLAVGLRDFWKRFPTGFDISSAASDTGSITLWLYSPSADPLDLRPYHDGLGQKNYTDQLDALEITYEDWEEGFDTPYGIARTSEVYLVAFDKTPSQDTLASYVSQINNPPVLVPEGEYISKTKALGSYWAPADTSSAASKKLEDNINFLAKFYQDEVEHRRWYGFLDYGDFMHTYDPDRHEWRYDIGGYAWDNSELSPDLFFWQYFLRTGREDIYRFAEALTRHTGEVDVYHIGNWKGLGTRHGVQHFSDSAKQARISQPQYRKYFYYLSGGDDRIGELFEELLDTDKTYGVLDPQRKVRKDGWVPTPNATVAFSLGTDWGALAGGWLIDWERRGPRWEESKAKLTSTVESIAKLKNGFVTGNGLYNLQNWTLGPPPADPDNKGHVDVSHLSAVFGLPEVVSELIEYAGDDLPKGFKQAWLDYCYYFEATAAEQQARYGKDFGKLNLYQGHSRLTAYAANQQKNGTMAKLVWEKFFNSDGFKAPVATFETTLIPDHEGLIPGKEAPWVSTNDVAQYGLAVIQNLALVRDSLEDFKPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1RHH6</accession>
    <accession>A0A098DGC8</accession>
    <name>I1RHH6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG03229.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T12371</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322526.1">
        <property type="nucleotide sequence ID" value="XM_011324224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RHH6"/>
    <dbReference type="EnsemblFungi" id="CEF77988">
        <property type="protein sequence ID" value="CEF77988"/>
        <property type="gene ID" value="FGRRES_03229"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03229"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12371"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008721_3_3_1"/>
    <dbReference type="InParanoid" id="I1RHH6"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF18">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="557"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="134"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="427"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="306"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF77988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="581" mass="62482" checksum="BCBA7FC0F7AFF9FC" modified="2012-06-13" version="1">MSPPLASETPRYNDCSLSSASEDDDDPSDPLNGSGPAGHHGHDFSIRDTMKRALRASSRLGDGVRYQQLGISSTSDLETQSPPNERSGFDFGTNHEGLSFFGQIRSTVVASRLNWLLVFVPIGLAAHTFEINPLVTFMTNAVAIVPLSVMLTEATERIAADAGDTIGALLNITLGNLVELIILVALVNNHIRIVQASILGSVLVNLLLILGSALFASSMSGIDAQSSMEESELLAALLFVSVFVILIPTAFDYTFHMKGKTSEAALSMSRASSLVVLVIYIVYFAYEMRPKHVEVPSIPLQTLHVGHSDHHHRRNQHSASQNSRLIRFADQDVPTRARSTTLESRVPRETTEEERGKREATSLASLSHRSRGNSRSHSRSGSRTEFHGSEARDLSVSSMHSRILPELPEIPNHTPHTSGTGSMVAAVTVLVVSSALMSMNAEFLVKTIDDVTHEGGLSEALIGLIILPIVGNIAEYVTVVTVAMRNKLELAISVAVGSAIQIALCVAPLTVLIAWILGRDLEMAFNVFETTTLVGSGLLINLLVLSRAGTAIRAIGLKGALMLACYTIIGLGAYFEPHATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1RIJ5</accession>
    <name>I1RIJ5_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="11">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">FG03632.1</name>
        <name evidence="15" type="ORF">FGRAMPH1_01T13337</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
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        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CEF78472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_011323766.1"/>
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    <dbReference type="STRING" id="229533.I1RIJ5"/>
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        <property type="protein sequence ID" value="CEF78472"/>
        <property type="gene ID" value="FGRRES_03632"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13337"/>
    <dbReference type="eggNOG" id="ENOG502SING">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF2">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124229" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="13">
        <location>
            <begin position="18"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="14">
        <location>
            <begin position="18"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="247"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
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    </evidence>
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            <dbReference type="EMBL" id="CEF78472.1"/>
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    </evidence>
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            <dbReference type="EnsemblFungi" id="CEF78472"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="331" mass="33963" checksum="5C7B774779875C80" modified="2012-06-13" version="1">MKFSTIALAALTQVASAHYFFDVATVNGKDSAPFQYIRDFTRPTKYNPIKFSSNPSADIRDNSFADGEDIVCNQGAATKGASTEVADVKAGDVITFKLGVGAKMGHPGPTLAYMSAAGSDVKSYKGDGDWFKIMEEGVCNAGGDFTKDAWCNYDSPSADVKIPEGTPDGQYLLRVEHIGVHRSHVNQPEHYVSCMQVSVTGGGSGKVDAEMVKFPGAYKATDEYANFSIYNGAKAFPMPGPKVWGGATSAGGATGGNDAPASTPAAGNDAPATTPDAGNGAAAPEAGNGQQQGGEQQQAPPQGNQGGFPGQQQGNQGGFPGAQSAGSPCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJH9</accession>
    <name>I1RJH9_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
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    <gene>
        <name evidence="3" type="primary">FG04000.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T14225</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321657.1">
        <property type="nucleotide sequence ID" value="XM_011323355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJH9"/>
    <dbReference type="EnsemblFungi" id="CEF78915">
        <property type="protein sequence ID" value="CEF78915"/>
        <property type="gene ID" value="FGRRES_04000"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04000"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14225"/>
    <dbReference type="eggNOG" id="ENOG502SD1T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166315_0_0_1"/>
    <dbReference type="InParanoid" id="I1RJH9"/>
    <dbReference type="OrthoDB" id="9999611at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF78915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="98" mass="10167" checksum="106F3DF3DC29CA27" modified="2012-06-13" version="1">MADNNNQQPGLIGSHAQYVKGAAEATIGAITGSQPWKASGEQDKAAGLADMKKAGELRAQNDPNNQNGYGKAEEIAGKLTGCQGMEREGHASAAQKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJQ5</accession>
    <name>I1RJQ5_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactokinase</fullName>
            <ecNumber evidence="3">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">FG04085.1</name>
        <name evidence="19" type="ORF">FGRAMPH1_01T14449</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="20">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="21">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="20">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="19 21" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="19">PH-1</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>alpha-D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:13554"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="3"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321555.1">
        <property type="nucleotide sequence ID" value="XM_011323253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJQ5"/>
    <dbReference type="FunCoup" id="I1RJQ5">
        <property type="interactions" value="1067"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RJQ5"/>
    <dbReference type="EnsemblFungi" id="CEF79028">
        <property type="protein sequence ID" value="CEF79028"/>
        <property type="gene ID" value="FGRRES_04085"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04085"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14449"/>
    <dbReference type="eggNOG" id="KOG0631">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_6_2_1"/>
    <dbReference type="InParanoid" id="I1RJQ5"/>
    <dbReference type="OrthoDB" id="187738at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000411">
        <property type="term" value="P:positive regulation of transcription by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.340:FF:000003">
        <property type="entry name" value="GAL1p Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000056">
        <property type="entry name" value="GAL1p Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="18">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="16">
        <location>
            <begin position="135"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="17">
        <location>
            <begin position="421"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CEF79028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="526" mass="57175" checksum="04E067527C2DBAE1" modified="2012-06-13" version="1">MSSSVPVANALSDIYPQDALAEQGPRWNNLLTKFESTYGHAASFVARSPGRVNIIGEHIDYSLYSVLPMAITADTLLAVSATPAASDAKSFRIRIANVEDDKFEAADFEVPFDGEVSIDATKLEWTNYFKSGLRGVMDLLRKKHGKDFKPCNMELLMDGTVPVGGGLSSSAAVVSTSSLAIMLANGEKTVDKTELTELAIVNERAVGVNSGGMDQAASVFSEKGAATFVSFNPSLKAQPVHFPPTNPEITFVIVQSFVTSNKQVTGPIHYNLRVVECSIAASCLNAVLNPPGTLLPEDAGPLGVSLGGFHDTFFYHLNGSDYSAAKTLTKEEELEKLIEITEKTLTQEEGYTREEVAKVLNVTVEDLEKRFMSKLPVRAERFKLRQRALHVFREAHRVIRFMKLLENPVHTGASDTTKFNAELGSLLNETQASCRDLYECSSPELDEICAISLREGSYGARVTGAGWGGCSVHMVPADKVAAVTRALEKEYFAKRDLTEDQKKGSVVVSRPATGSAIYYIQNGVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RKK9</accession>
    <name>I1RKK9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG04420.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T15245</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321185.1">
        <property type="nucleotide sequence ID" value="XM_011322883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RKK9"/>
    <dbReference type="STRING" id="229533.I1RKK9"/>
    <dbReference type="EnsemblFungi" id="CEF79423">
        <property type="protein sequence ID" value="CEF79423"/>
        <property type="gene ID" value="FGRRES_04420"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04420"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15245"/>
    <dbReference type="eggNOG" id="KOG4313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048013_0_0_1"/>
    <dbReference type="InParanoid" id="I1RKK9"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="136"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF79423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="314" mass="35013" checksum="B236E46EF5C66CB5" modified="2012-06-13" version="1">MTTSTSSPRKLIHLITNIDNAPLDFASNFDPYYRLFLSPDPRPHGFILPATVSLMPWPSTFTIDHSARNVTLTSPPSSSSLTEHANAAFQEAVDKAIDDDLFPILHKEHSEYFRIVGARSFVQVERFAAPLFGIATRGAHLTGYIRDDGEIKIWVARRSRHLFSYPGLLDSTVAGGIKASDTPLACIKAESTEEACLPPDLVSTHVEPAGAITLANINANSKLFHSDIIYVFDLEMPRDVVLRPGDDEVEEFVLMGCGEVVERMLKGEFKPNVCPVMIDFLVRRGFITKKNEGDFEEIQKRLRREIPVPMESDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I1RL40</accession>
    <accession>A0A098DNX6</accession>
    <name>I1RL40_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG04620.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T15723</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320955.1">
        <property type="nucleotide sequence ID" value="XM_011322653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RL40"/>
    <dbReference type="STRING" id="229533.I1RL40"/>
    <dbReference type="ESTHER" id="gibze-q4idt8">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF79661">
        <property type="protein sequence ID" value="CEF79661"/>
        <property type="gene ID" value="FGRRES_04620"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04620"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15723"/>
    <dbReference type="eggNOG" id="KOG2984">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_47_1_1"/>
    <dbReference type="InParanoid" id="I1RL40"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124317" evidence="1">
        <location>
            <begin position="24"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="77"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF79661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="302" mass="33843" checksum="5EC8713191EF5716" modified="2012-06-13" version="1">MLSWSYLGVLALALSNLVDSSLGDKHKSNYTAPWQTLPPTPHLPEPNFNGTAPINGIDLWYATFGASLEISKRRDLNPVVFLHGVYTNSDYYGHQIRHLQDGLYTLMTIDSRAQGRSGDDPSRPLTYDLMTEDMVALMNYLKIDKFSTVGWSDGGCISFDLAMNYTPRIDRIFSFGGTYSPQNINATIDDSPVWGAYMKRVAKDYEHNAPSSVTFEEASKQLNSMWLTEPVWDATSFAKIPSRYDDDEAPMIWIVDGDSEEAVIRDTPGTLRSWIWGSDLVILPGVSHFAVNDLYMAVESDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>I1RMJ3</accession>
    <accession>A0A098E5C7</accession>
    <name>I1RMJ3_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 20">Glutathione reductase</fullName>
            <ecNumber evidence="4 20">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">FG05183.1</name>
        <name evidence="23" type="ORF">FGRAMPH1_01T17301</name>
    </gene>
    <organism evidence="23 25">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="24">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="24 25" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="25">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="24">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="23 25" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="23">PH-1</strain>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 20">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="17">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="4 20"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323689.1">
        <property type="nucleotide sequence ID" value="XM_011325387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RMJ3"/>
    <dbReference type="SMR" id="I1RMJ3"/>
    <dbReference type="FunCoup" id="I1RMJ3">
        <property type="interactions" value="1120"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RMJ3"/>
    <dbReference type="EnsemblFungi" id="CEF88598">
        <property type="protein sequence ID" value="CEF88598"/>
        <property type="gene ID" value="FGRRES_05183"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05183"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17301"/>
    <dbReference type="eggNOG" id="KOG0405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_2_2_1"/>
    <dbReference type="InParanoid" id="I1RMJ3"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000141">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000671">
        <property type="entry name" value="Thioredoxin reductase 2, tandem duplicate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 20" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 17 19" id="KW-0274">FAD</keyword>
    <keyword evidence="7 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-0520">NAD</keyword>
    <keyword evidence="9 20" id="KW-0521">NADP</keyword>
    <keyword evidence="17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13 19" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="22">
        <location>
            <begin position="46"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="21">
        <location>
            <begin position="393"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="221"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="83"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF88598.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF88598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="506" mass="54831" checksum="78F4EC16D9330E4F" modified="2012-06-13" version="1">MQALAHSLRSSTLSSSSRTTPLRIASITRHLSTSARNMAPVTKETDYLVIGGGSGGLASARMASNKFGIKATIVENKRLGGTCVNVGCVPKKVTYNAAALAEAIHDSKAYGFSVQETAPFDWSTFKTKRDAYIKRLNGIYERNLNNDKVDYVHGWARLTSKNQAEVTLDDNSKVLINAKKILVAVGGKPTIPPEIPGSEYGTNSDGFFDISTQPKKVAIVGAGYIAVEFAGMFNALGTETHLFIRHDTFLRNFDPMIQEAVTKEYERLGVKLHKRSQASKIEKDSNGKLTVTYKDDQGNESVVSDVDNLIWAIGRTPETKGIGLEEAGVKLAKSGHIIVDEYQNTDVDSIYALGDVTGEVELTPVAIAAGRRLAHRLFGGAEFSTLKLDYSNIPSVVFSHPEVGSIGLTEPEAIEKYGKDNIKVYKTSFTAMYYAMMEPEQKGPTNYKLITTGPEEKVVGLHIMGIGSGEMLQGFGVAIKMGATKADFDSCVAIHPTSAEEIVTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1RMN5</accession>
    <accession>A0A098E493</accession>
    <name>I1RMN5_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
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    <gene>
        <name evidence="3" type="primary">FG05228.1</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323739.1">
        <property type="nucleotide sequence ID" value="XM_011325437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RMN5"/>
    <dbReference type="STRING" id="229533.I1RMN5"/>
    <dbReference type="EnsemblFungi" id="CEF88412">
        <property type="protein sequence ID" value="CEF88412"/>
        <property type="gene ID" value="FGRRES_05228"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05228"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17415"/>
    <dbReference type="eggNOG" id="ENOG502SG9Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_672762_0_0_1"/>
    <dbReference type="InParanoid" id="I1RMN5"/>
    <dbReference type="OrthoDB" id="3648773at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="374"/>
        </location>
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        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CEF88412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="394" mass="43892" checksum="F7CD4C0EA0918972" modified="2012-06-13" version="1">MNEPKYLRPMPTVGYWAERQLMAQRKSNSSRSFFRWRNHSTTKSASESDVRDLSLGSPLASLSAPPNFHGFEPPQQRPPSSPFVSESAHVFSLQHPSTNLFSDNTQDFSSVSQSVDRDSTDSISPMHNWVPSRKTDTPPSTPRSSGSLYGKAKKSIGSKLKFRIRKEATPYSAMPEHEHQCSTVGDTRNYTTMHQITKTGSYFKDDVSRIKLRRRFFGRPPWGRKESGDSYSSVTSSVREILKGETPPPSLGSSSASLRVNCVDSPYPGGEARRIKTPPLTDGAVNCRPRSFFTETITSTDLDEVDIHGSSSRRHSLQIVCHKSYSPDSAEWREKIPKQPVRRSPHEGPAPFEFQLPEHLPSSPMCPANEKHVGGGKGVCVYHGRRKGASKMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>I1RN81</accession>
    <accession>A0A098E0E9</accession>
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        <submittedName>
            <fullName evidence="12">Chromosome 3, complete genome</fullName>
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        <name evidence="13" type="primary">FG05447.1</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323985.1">
        <property type="nucleotide sequence ID" value="XM_011325683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RN81"/>
    <dbReference type="FunCoup" id="I1RN81">
        <property type="interactions" value="909"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RN81"/>
    <dbReference type="EnsemblFungi" id="CEF87082">
        <property type="protein sequence ID" value="CEF87082"/>
        <property type="gene ID" value="FGRRES_05447"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05447"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17935"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_3_1"/>
    <dbReference type="InParanoid" id="I1RN81"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="PHI-base" id="PHI:3832"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000236">
        <property type="entry name" value="Cell division control protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF87082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="195" mass="21738" checksum="B8F34AE14B50DCE7" modified="2012-06-13" version="1">MAVVATIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGDEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVTSPASFENVREKWFPEVRHHCPGVPCLIVGTQVDLRDDPSVREKLSKQKMQPVRREDGERMAKDLGAVKYVECSALTQYKLKDVFDEAIVAALEPPAPKKKSHKCLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQA2</accession>
    <accession>A0A098E2K7</accession>
    <name>I1RQA2_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleolar protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG06243.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T19849</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324891.1">
        <property type="nucleotide sequence ID" value="XM_011326589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQA2"/>
    <dbReference type="SMR" id="I1RQA2"/>
    <dbReference type="FunCoup" id="I1RQA2">
        <property type="interactions" value="752"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RQA2"/>
    <dbReference type="EnsemblFungi" id="CEF87857">
        <property type="protein sequence ID" value="CEF87857"/>
        <property type="gene ID" value="FGRRES_06243"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06243"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19849"/>
    <dbReference type="eggNOG" id="KOG1122">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_3_2_1"/>
    <dbReference type="InParanoid" id="I1RQA2"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000001">
        <property type="entry name" value="Ribosomal RNA methyltransferase Nop2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023273">
        <property type="entry name" value="RCMT_NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02012">
        <property type="entry name" value="RCMTNOP2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="303"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="594"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="520"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="395"/>
            <end position="401"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF87857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="678" mass="74756" checksum="804F41718B90AFB9" modified="2012-06-13" version="1">MGVGRRMKKQGPPQPLSEEHFAKLKRKAGLPADPVVETPERKKRKTVTKEKLVESKKNGVAKKDVKKTKVTKPVKAAAAPDSTSAPKVNPRSKKSKKAPVPALEDLSDEEMDDEFDLDDLEDGSSDLGGAGLKDDFLESDNDDDSVLDSDEEGGKGTRAMFSEDEDESDAEEKLTAANIEGLTRKLDLQRAEEAAEAEAEMAEQALQTNIDGDKPHILSDEDSDDELATKTQALLAPDLQLLRTRITENIRVLDDFAKLSEEGRSRTEYVSQLLKDICSYYGYSAYLAEKLFNLFTPREAFAFFEANESARPVVIRTNTLRTHRRDLAQALINRGVTLEPVGKWSKVGLQVFESSVPLGATPEYLAGHYILQAASSFLPCMALDPQENERVLDMASAPGGKTTYMSAMMKNTGIVVANDPNKARAKGLIGNIHRLGCRNVIVSNYDAREFPKPMGGFDRVLLDAPCSGTGVIAKDPSVKTNKTELDFMQLPHLQKQLLLAAIDSVNHASKTGGYIVYSTCSVTVEENEQVVNYALSRRPNVRLVDAGLTFGKEGFTSYMGKKFDPSVSLTRRFYPHSLNVDGFYVAKFQKIGPTPASASNARDRTTGPADETEFIDKTPIATDDEESGKKSDDFGGWDDDEDKEYMEKGRRNAMRRRGLDPNSNSKKAKAKKEKESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQK4</accession>
    <accession>A0A098DZP8</accession>
    <name>I1RQK4_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG06349.1</name>
        <name evidence="6" type="synonym">TSR3</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T20093</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63300"/>
            <dbReference type="Rhea" id="RHEA-COMP:13852"/>
            <dbReference type="Rhea" id="RHEA-COMP:16309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325006.1">
        <property type="nucleotide sequence ID" value="XM_011326704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQK4"/>
    <dbReference type="FunCoup" id="I1RQK4">
        <property type="interactions" value="826"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RQK4"/>
    <dbReference type="EnsemblFungi" id="CEF86812">
        <property type="protein sequence ID" value="CEF86812"/>
        <property type="gene ID" value="FGRRES_06349"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06349"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20093"/>
    <dbReference type="eggNOG" id="KOG3154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035060_0_2_1"/>
    <dbReference type="InParanoid" id="I1RQK4"/>
    <dbReference type="OrthoDB" id="10262062at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="76"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="209"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF86812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="398" mass="44906" checksum="A2CC9BCBDDAFACC3" modified="2012-06-13" version="1">MVRHKKDFTSKGRKGGPTPRRGPRRDEEDGSESSRPAFKAACWDLGHCDPKRCSGKKLMKLGMMRDLHLGQRHNGVIITPNGKHTVSPADRELMDQYGAAVVECSWARTQEVQWNKVGGKCERLLPYLVAANTVNYGKPWRLNCVEALAAAFYICGHPDWAEQILAPFSYGPSFLQINSTLLKRYAACADEAEMKKTEEEWMEQLEREYAESREEGNDDMWTSGNTNRRRMESSDEEEEDDGDEGDSDEEEGSVDGIYLGKKPSKANPEEEEEGEEEEKDRYAISDDSDDEDTMAEIRRKVLASKTFANPNEQEDKKPATIPNPQQQQQQFKPNTSVQPDSDNERSGSDDDDDEFDNIIEATPVTDRIGLAKLEKERSQATRTTRTFSSNAVGAPYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQU0</accession>
    <accession>A0A098DQ71</accession>
    <name>I1RQU0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG06440.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T22283</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326038.1">
        <property type="nucleotide sequence ID" value="XM_011327736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQU0"/>
    <dbReference type="EnsemblFungi" id="CEF83013">
        <property type="protein sequence ID" value="CEF83013"/>
        <property type="gene ID" value="FGRRES_06440"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06440"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22283"/>
    <dbReference type="eggNOG" id="ENOG502SIZK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070115_0_0_1"/>
    <dbReference type="InParanoid" id="I1RQU0"/>
    <dbReference type="OrthoDB" id="5372266at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF92">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="27"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF83013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="292" mass="32784" checksum="E33EAEC715DA7BBB" modified="2012-06-13" version="1">MAFFIDGKDCMISEWILLAVSYLFVGLRIYARLFRARQKLDASDWLLVVSAFNALALIICDTLTYQMGVLDEYETSVKLSKVWWPRHNNDMGATNTDAQISFASNYFYDFGMGFPKLSMLAFYWAYFLPSNGVSSAMRKTLYGITAFVCISYLVILFDDTFFCGKDVSVQWSQEEGACSVFYAPEPFILNFTLNLACYFAVYALPLILLVQGVLKTSTGVMVTFVLGALTICTTMVRFITLKVGTGQENLVYPLSMLEMALAITVVALPGLRPLVSRPVKHETANESFYVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1RR16</accession>
    <accession>A0A098DWL3</accession>
    <name>I1RR16_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG06520.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T22491</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326130.1">
        <property type="nucleotide sequence ID" value="XM_011327828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RR16"/>
    <dbReference type="STRING" id="229533.I1RR16"/>
    <dbReference type="EnsemblFungi" id="CEF85268">
        <property type="protein sequence ID" value="CEF85268"/>
        <property type="gene ID" value="FGRRES_06520"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06520"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22491"/>
    <dbReference type="eggNOG" id="ENOG502RJ7S">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_1138076_0_0_1"/>
    <dbReference type="InParanoid" id="I1RR16"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
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        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="54"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF85268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="252" mass="29009" checksum="EDDC1C9E25F2D774" modified="2012-06-13" version="1">MTLQSTNVMSINNILNPEPSPPVNQPQLSNTYWPILRDALLRDPSSYHNLHLECVICLEDMTVFQHEHTYDPLMSHLSHRARIFPCGHMFGSKCAMTMIDELVRSNQPIACPICRVNFSHHRDCDHVHSGMPMPTSIREISPTLLFPFELDEGDSLFVSARTRCHVWDLRAMDSVEGYDVQDVIIEGPLKKVFDEIKARLKDNATRSWYSTDLKGFELCIRSCQRRRMSFVDVVREHQSAWNARPIIGTSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RU65</accession>
    <accession>A0A098DQ63</accession>
    <name>I1RU65_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG07748.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T25553</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327559.1">
        <property type="nucleotide sequence ID" value="XM_011329257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RU65"/>
    <dbReference type="EnsemblFungi" id="CEF83003">
        <property type="protein sequence ID" value="CEF83003"/>
        <property type="gene ID" value="FGRRES_07748"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07748"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25553"/>
    <dbReference type="eggNOG" id="ENOG502RW5A">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_000288_125_7_1"/>
    <dbReference type="InParanoid" id="I1RU65"/>
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    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR35205">
        <property type="entry name" value="NB-ARC AND TPR DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR35205:SF1">
        <property type="entry name" value="ZU5 DOMAIN-CONTAINING PROTEIN"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <property type="entry name" value="TPR-like"/>
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        <location>
            <begin position="236"/>
            <end position="361"/>
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        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF83003.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF83003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="828" mass="95120" checksum="96D4FAC196ACBAA0" modified="2012-06-13" version="1">MDQLTKIWLEAQVLQRQHLTVKEKETVEQIDSYEHLCEKLGKIQAQYKLERWVRLLARMDPFVSRLRSFATVLSVFAQAKPEVLSFVWGSVALVLECYVEEYMSPSPTITHLRDAIRRYYQELIDQCQDYIRFLKASPLKNFLLLGRTSRKLRTNSTRRLKRLRHLSIDVEQEARIEEHRITYRTLNSLRVEPTMATVLPYHGVTYRQNPAFYPRPQYLEQISAVLGPDTPRGLTSFALVGFGGCGKTQLAIEYTHRTNHYDAIFWCAAENSLQLSESFAMHARQLDLIKGDDVPQQDRIISLVKQRLLSLSVNGKPSRWLMVFDNMEPFDGLSSFWPSGLSGSILVTTRNKTLAKEFTKSQVSIPPFEPLDAQRFLLQYRTSGTEHTCQEDNAAEIISQRLGNLPLALDLVRHHVSASGSSYKEFLRCYGEPSEPLLLCNGPDVEDELPQLQDLLESPVANIYELDTVVSELMDGSLIDRNVGSGSLSLHRILQDSVAHSFDAATRSRSFSKILFYLNGCFPTQRDGGLLFEQWYLCEQYIPHIFSVVQFYRKNIKLLDPPVMLAEIIRRYLLEKHQFTEAKILVRDAVEICKRARTSSNLLGFTQYRYIPRLLSDLYNVMGALEYESNTEGHGLRWAMKARSIRQELCLTLDLERDKCMLQVFQHNIALDMLANGQLREALPLLEAVHEYDASTSGVNTDNFYRTLSLSICYRLLGKYIHAMDCSNIAMKVIQEHIGEDSVPMATARFCWGNLLLCMEDRVGAYNAFSMCFLTRQKLMPTHFDTAFTAHKLGAMALQNGDLGASMYGFYLFTLSQRNFYKLTNQWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1RUB4</accession>
    <name>I1RUB4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG07801.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T25699</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LovG family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF82862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327621.1">
        <property type="nucleotide sequence ID" value="XM_011329319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RUB4"/>
    <dbReference type="STRING" id="229533.I1RUB4"/>
    <dbReference type="EnsemblFungi" id="CEF82862">
        <property type="protein sequence ID" value="CEF82862"/>
        <property type="gene ID" value="FGRRES_07801"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07801"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25699"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_0_2_1"/>
    <dbReference type="InParanoid" id="I1RUB4"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF3">
        <property type="entry name" value="ESTERASE DBAE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF82862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF82862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="233" mass="26040" checksum="9D89407A888BE852" modified="2012-06-13" version="1">MSHYPRLLCLHGGGASSRIMRAQFAKLESALSNRFQLVYLEAPLDSAPGPGVLPYFENCGPYSCWVSDDKTLAPEDKRMEEENAIAYTKNFMVQHGPFAGILGFSQGARATASILIEQQQRPFTHDNLFGVFFCGTFPPFVSETPEIQISTVHIQGLTDPYLEESEMLLSHCTKQSVRRVIKFDGGHHMPTSLGVTRQIADVISMVHRTTNRKKVSNLWKLKRPVPTTTAIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1RUG9</accession>
    <name>I1RUG9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG07862.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T25841</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327690.1">
        <property type="nucleotide sequence ID" value="XM_011329388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RUG9"/>
    <dbReference type="STRING" id="229533.I1RUG9"/>
    <dbReference type="EnsemblFungi" id="CEF84899">
        <property type="protein sequence ID" value="CEF84899"/>
        <property type="gene ID" value="FGRRES_07862"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07862"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25841"/>
    <dbReference type="eggNOG" id="ENOG502S8V6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098389_0_0_1"/>
    <dbReference type="InParanoid" id="I1RUG9"/>
    <dbReference type="OrthoDB" id="5689at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050832">
        <property type="entry name" value="Bact_Acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
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    <dbReference type="PANTHER" id="PTHR43877">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GNAT"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF84899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="172" mass="19287" checksum="F23F3622C062BEC3" modified="2012-06-13" version="1">MSNNYHFRIATADEAPHLQNLIHAAFRFTGASIEWIGSPELAETFTMDMGVIVERIKSPENVFFILSDEPNGPAIGCVNVFKKGPDYGRIALLAVDPTIQRSGLGKIVMNKAERHLKEEFGVKRIGLNALQTRKGLIAWYERQGYVKTGDLERIPIEGSEDEIVLIEFEKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1RUR7</accession>
    <name>I1RUR7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG07969.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T26103</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327816.1">
        <property type="nucleotide sequence ID" value="XM_011329514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RUR7"/>
    <dbReference type="EnsemblFungi" id="CEF84347">
        <property type="protein sequence ID" value="CEF84347"/>
        <property type="gene ID" value="FGRRES_07969"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07969"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26103"/>
    <dbReference type="eggNOG" id="ENOG502RR5Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036424_0_0_1"/>
    <dbReference type="InParanoid" id="I1RUR7"/>
    <dbReference type="OrthoDB" id="5207413at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF84347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="419" mass="47320" checksum="635816C9182A55B5" modified="2012-06-13" version="1">MGDRPAIYVHLEMGLSLPKIMSKDRHITYISKSMRDRANQFPRQLPPTNTNYLNAPSQYQAGNQQMLRQTQLPQDQLQHQFAYRVSNIPPHTYGRDPVPAGLVQEQSYQPYRPQQVQHDIREYYAPVPSAAAQQGTLQPDEVPRSSRSTSRGSHERGKSAPPPLNSSPWDMSPSHASGSEPHLWKALPATPNQFRLGEGDMPWDSWTFPMGIDDNNEEDDHGEGGDGRIRSREASIRATWGPEFPGEYSRPSQFVQVDDRATGKAKDIQSLASALMTVDNGFEDQWWYQGPRLVNIHGNVMVPTAVPKSSFHPDHQQSSVGWAVSHEEAQRLKDQNDQHQLQQKRQEQQRRRQRHLSFQEQQLESFVPSDASLQLVSPHSLSGTGTADIVSPLSDYPSPLSNYGGLRRSLTTRSDELHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1RV91</accession>
    <name>I1RV91_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG08156.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T09247</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320657.1">
        <property type="nucleotide sequence ID" value="XM_011322355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RV91"/>
    <dbReference type="STRING" id="229533.I1RV91"/>
    <dbReference type="EnsemblFungi" id="CEF76426">
        <property type="protein sequence ID" value="CEF76426"/>
        <property type="gene ID" value="FGRRES_08156"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08156"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09247"/>
    <dbReference type="eggNOG" id="ENOG502SMYN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027438_0_0_1"/>
    <dbReference type="InParanoid" id="I1RV91"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF76426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="414" mass="45764" checksum="19CE9215B6D32444" modified="2012-06-13" version="1">MLEHLAPWSPTTEVTTKVKIDDLEIRFKRTIRVPDNDDTNDLPPDAGSFPLYKVDDYADALPLSMAQKGGLFIPMYQKEAIWVGFTSMRRYAIEVFVGGINAVSGEPIVADAATALRRRNLIRQGKSVQDYVVVPGQHWLDGIAFGQGNVRQFVAMPAGKGHSVESQITGEEVTGGIQFNISRLDIMPRDIKKEDEITLMVQSLNRGYISLKASQADTVAEFKARFEAKEKVPADLLHHETLAEYHLPNHGLIQTATRLRGGAVGNSAEMHMAAGGRITQGIVALQKLRYSKTVPVTFNVQVLNSASFERVTGKKPPQSPITAKWYADAGYPFFSIYEEPTTICGDFTGVKSIAEIDGTTEESMPVGMPVVDCITRKVRPGKGAVGLFNPQALDLKLELEWELVERLQKMRTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1RV98</accession>
    <accession>A0A098DDC9</accession>
    <name>I1RV98_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG08164.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T09265</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320648.1">
        <property type="nucleotide sequence ID" value="XM_011322346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RV98"/>
    <dbReference type="EnsemblFungi" id="CEF76435">
        <property type="protein sequence ID" value="CEF76435"/>
        <property type="gene ID" value="FGRRES_08164"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08164"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09265"/>
    <dbReference type="eggNOG" id="ENOG502R6R2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1786959_0_0_1"/>
    <dbReference type="InParanoid" id="I1RV98"/>
    <dbReference type="OrthoDB" id="5076774at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124573" evidence="1">
        <location>
            <begin position="22"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="47"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF76435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="145" mass="15858" checksum="C471B975B9075DF9" modified="2012-06-13" version="1">MPSTKTIAVAVAALAASGVSANKCNPSACTTYDLKTESEIETEELNCNKRGAFKDTDSYSLPSWSMYDCAKSCYDYEQFTCQQFSFTPGEEAGIQGFCTLYPDNEIPGNIRGPLAYYDKKCFKCSPPPSRGGRGGAKIRGRIRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RVL0</accession>
    <name>I1RVL0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG08291.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T09579</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320502.1">
        <property type="nucleotide sequence ID" value="XM_011322200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RVL0"/>
    <dbReference type="STRING" id="229533.I1RVL0"/>
    <dbReference type="EnsemblFungi" id="CEF76592">
        <property type="protein sequence ID" value="CEF76592"/>
        <property type="gene ID" value="FGRRES_08291"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08291"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09579"/>
    <dbReference type="eggNOG" id="ENOG502SGSI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152075_0_0_1"/>
    <dbReference type="InParanoid" id="I1RVL0"/>
    <dbReference type="OrthoDB" id="2561686at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="98" mass="10156" checksum="F5F8C912FCA2F506" modified="2012-06-13" version="1">MAITSAINDLFASIYELLASVFNTVYTIIHSILSAVLGFVQGLFNLIGDVVSGLVDVTGGVGKFVASNAAILAVGALGAFAYVRYTAQGKQVANKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>I1RXF5</accession>
    <name>I1RXF5_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG09021.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T28105</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328780.1">
        <property type="nucleotide sequence ID" value="XM_011330478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RXF5"/>
    <dbReference type="STRING" id="229533.I1RXF5"/>
    <dbReference type="EnsemblFungi" id="CEF85498">
        <property type="protein sequence ID" value="CEF85498"/>
        <property type="gene ID" value="FGRRES_09021"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09021"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G28105"/>
    <dbReference type="eggNOG" id="KOG0859">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064620_1_1_1"/>
    <dbReference type="InParanoid" id="I1RXF5"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000017">
        <property type="entry name" value="Synaptobrevin-like protein Sybl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="11"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="149"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF85498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="236" mass="26217" checksum="5B42E4B75B157EF5" modified="2012-06-13" version="1">MASSSTPSTPLLYSCIAHNTTILSECTTSASSQTSSLASLILPKIEHTNPQKLTYTHGQHQIHYVAESPSEHRDYPSAGGLTFLVIADSSLGRRVPFGYLFEIRKRFLQQFPESTDFSDMPNYGAASFNSELKNLMVDYGTTTGGRDDAIGNAKREIDDVRGIMTKNIESLLERGERLDLLVDKTDRLGGSAREFRVRSRGLKRKMWWKNVKLMGLLALVIFLIIMAIVIAVKNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1RXN9</accession>
    <accession>A0A098DRD4</accession>
    <name>I1RXN9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T27895</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328676.1">
        <property type="nucleotide sequence ID" value="XM_011330374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RXN9"/>
    <dbReference type="EnsemblFungi" id="CEF83927">
        <property type="protein sequence ID" value="CEF83927"/>
        <property type="gene ID" value="FGRRES_09113"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09113"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27895"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_8_0_1"/>
    <dbReference type="InParanoid" id="I1RXN9"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF83927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="533" mass="60650" checksum="22192E1F1FB7FCB2" modified="2012-06-13" version="1">MSEHTIVLDALIVGGGFGGVYQLKRLRDEGFNVKLVDMASDYAGVWFWNRYPGARVDSSVPHYEFSDPELWRDWNWTERFPGSAELRDYFAYVAKKWELRKDTLFNTCISQCDWDEKTNRWTIQSKDGKRFSAQYLLLNTGFAAKRHTPDWKGIDQFQGNWIHPSYWPHEDPDLKGKKIAVIGTGSTGVQLAQELSKVASEFVLFQRSPNLALPMKQIKYSPKSIPEDRYKEVYQGRHDSFSGFDFNFLPRNTFSDDPKSRLALYEDLWTHGDFHFWLATYQDMLFDEKANEEAYNFWKSKVRCRINDPRHQELLAPEKQPYSFGCKRISLESGYFEIFNQPNVSLVDVNATPVVEVTERGIKTTEKEWEFDIVVCATGFDAITGGMLDMNITGASGLKLTDKWKTGAKTYLGMAVAGFPNMFFTYGPQAPTALCNGPTCAESQGEFIVSLMKYMSKNGSRAVDASQESEAEWGATVRDFANTSLLPSTKSWYMGDNIPGKPRECLIYLGGVPTYTKALKGCGDSGYKGFQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZ19</accession>
    <accession>A0A098DUY2</accession>
    <name>I1RZ19_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG09637.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T26619</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_011329769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZ19"/>
    <dbReference type="STRING" id="229533.I1RZ19"/>
    <dbReference type="EnsemblFungi" id="CEF84663">
        <property type="protein sequence ID" value="CEF84663"/>
        <property type="gene ID" value="FGRRES_09637"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09637"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26619"/>
    <dbReference type="eggNOG" id="ENOG502S7XT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033652_0_0_1"/>
    <dbReference type="InParanoid" id="I1RZ19"/>
    <dbReference type="OrthoDB" id="2530523at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="142"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="314"/>
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        <location>
            <begin position="454"/>
            <end position="499"/>
        </location>
    </feature>
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        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF84663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="499" mass="54229" checksum="C65EB92018424870" modified="2012-06-13" version="1">MYSAGYNFGNNAAPSFNNPAPQQQSGAQPAAQQMMYNQQQQFAGMAPQGGFNPGANPQMMAGGPGGMMPNAGMQHMAANSQMAGFQQQFSGNPYGQVVPSSVAPQSFTPNYMMGGGMQGFPMNQGGMPQQPHMMQRMQQQQQQQQQQQQQQQQQQQQQAQAQAQAQAQAQAQAQAQAQAQAQAQQQQQQQQQQQAANAAGMGQVSTPQRPPSAAQGTPNNALPSQQGQFPTPQQPPQSQTPTNHQQQQQQRQQSQPPQLQQQQPQQPQGQMQGQVQQQQPPSALTTPQTPTFSNQGQAVNGSSSAAVPLSPGTESRDKERFALLLDINHELLYESIQIQETQKKLKKESAAAGIPGDNKPSEEEAQLQHDYLQCMRRLQANLSYMAALADRKPEVKVPPCPAYLNAPPLNLSAKLRPPEIEGIENNIDPVADREERNNSIKDLYSRLQAAFPGFDPKKEPVFRANAQGGQKPGNMMGSQASPTAQRTPKMTNMGAPPMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1S0F5</accession>
    <name>I1S0F5_GIBZE</name>
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        <recommendedName>
            <fullName evidence="2">Multiprotein-bridging factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG10179.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T07467</name>
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    <organism evidence="11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319121.1">
        <property type="nucleotide sequence ID" value="XM_011320819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S0F5"/>
    <dbReference type="FunCoup" id="I1S0F5">
        <property type="interactions" value="779"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1S0F5"/>
    <dbReference type="EnsemblFungi" id="CEF75538">
        <property type="protein sequence ID" value="CEF75538"/>
        <property type="gene ID" value="FGRRES_10179"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10179"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07467"/>
    <dbReference type="eggNOG" id="KOG3398">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112609_0_0_1"/>
    <dbReference type="InParanoid" id="I1S0F5"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="PHI-base" id="PHI:1533"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000030">
        <property type="entry name" value="Coactivator bridging factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="9">
        <location>
            <begin position="94"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF75538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="152" mass="16323" checksum="7C6BDC9003B203D7" modified="2012-06-13" version="1">MDDWDTATKIGSRARGPGNAQRETVVRGKAALNAAQRAGGLTTEKKYSSANAGSAPEGQRMTKVDRSDDIIKPNTIGKTVGDVIAKTRQQIEPKMTQKDLATRCNTTQAVVAEFERGSAAPDQKVLGAMERVLNVKLRGTDIGAPKFPNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1S0N1</accession>
    <name>I1S0N1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG10265.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T07683</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319218.1">
        <property type="nucleotide sequence ID" value="XM_011320916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S0N1"/>
    <dbReference type="EnsemblFungi" id="CEF75645">
        <property type="protein sequence ID" value="CEF75645"/>
        <property type="gene ID" value="FGRRES_10265"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10265"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07683"/>
    <dbReference type="eggNOG" id="KOG4491">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036918_1_0_1"/>
    <dbReference type="InParanoid" id="I1S0N1"/>
    <dbReference type="OrthoDB" id="30881at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF75645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="374" mass="39950" checksum="F4637D8374B84E04" modified="2012-06-13" version="1">MRLLYAVPATCALIYRAKSRNSLTPAGIFAATLTAIAHAYHPWNLPFALLCIFFLAGTRVTHIKEGIKADYTVRSKGTSGGEGPRTHVQVLANSLMASVLSLLHANQLRKREAAFADPNTPDPTGSLCFSWGGDLLVIGIIANYAAVAADTFSSELGILSSGQPRLITSPTLRKVPRGTNGGVTLLGLGAGLLGSIIIVTASMLFLPSCTEESAQTPAGGAPWTMLERRKFMGFMVLWGGLGSVLDSFLGGLFQRSVRDVRSGKIVEGEGGNRVLVAESAEGSAAHLKKEDVKEKSDDSAITDDHDAHAEVYNPKDKHRKSSFGDQRPSRTIENGWDLLDNNDVNFLMAAMMSVGGMAAASWYWDVPIQSVMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1S1J9</accession>
    <accession>A0A098DAR2</accession>
    <name>I1S1J9_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">laccase</fullName>
            <ecNumber evidence="4">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">FG10604.1</name>
        <name evidence="17" type="ORF">FGRAMPH1_01T08511</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF76058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319608.1">
        <property type="nucleotide sequence ID" value="XM_011321306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S1J9"/>
    <dbReference type="SMR" id="I1S1J9"/>
    <dbReference type="STRING" id="229533.I1S1J9"/>
    <dbReference type="EnsemblFungi" id="CEF76058">
        <property type="protein sequence ID" value="CEF76058"/>
        <property type="gene ID" value="FGRRES_10604"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10604"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08511"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_3_2_1"/>
    <dbReference type="InParanoid" id="I1S1J9"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000046">
        <property type="entry name" value="Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF502">
        <property type="entry name" value="MULTICOPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="69"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="195"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="410"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CEF76058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="566" mass="62536" checksum="B61680ED789AF2CB" modified="2012-06-13" version="1">MRFYNLLSAGLFGLAQANAHRHAMLHRRASCDGNTASTRSTWCDYSIDTDYSTEVVDTGVTKEYWLELTDVTVAPDGYSRSAMAVNGTIPGPTLFADWGDTVVVHVTNSLTTSLNGTSMHWHGIRQNYTNQYDGVSSITECPLAVGETVTYTWKATQYGSTWYHSHWALQAWQGIFGGIIINGPATADYDEDLGMVFLNDWDHQTVDELYYSAETNGPPTLDNGLINGTNVYGDDDDSSQTGSRFNVSFESGTSYRMRLVNAAVDTHWKFSIDNHTMTVIAADLVPIEPYETTVLDMGMGQRYDIIVTADQADVADNFWMRAIPQSACSDNDSTDNIKGIVYYGDSPDTPSTTAYDYTDGCDDETDNLVPYISKTVDDANWSDLETATVGKNTAGLFKWQLNSTSMLMDWANPTLAQIMNGTTEFETDDAVIELSEASQWVYFVIETSLAVPHPIHLHGHDFSILAQGTGTYSSSVTLNTSNPPRRDTAMLPGNGYLVMAWETDNPGVWLCHCHIGWHTSEGFALQFIERASEIPDITTSSYVSDVCDSWTTFQSENSIEQEDSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1S217</accession>
    <name>I1S217_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG10798.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T20497</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325602.1">
        <property type="nucleotide sequence ID" value="XM_011327300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S217"/>
    <dbReference type="STRING" id="229533.I1S217"/>
    <dbReference type="EnsemblFungi" id="CEF86796">
        <property type="protein sequence ID" value="CEF86796"/>
        <property type="gene ID" value="FGRRES_10798"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10798"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20497"/>
    <dbReference type="eggNOG" id="ENOG502S1YN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024412_1_0_1"/>
    <dbReference type="InParanoid" id="I1S217"/>
    <dbReference type="OrthoDB" id="2440523at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF2">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="PARG_cat_microb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microbial-type PARG catalytic" evidence="2">
        <location>
            <begin position="93"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF86796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="343" mass="38809" checksum="F2006591ADE042E3" modified="2012-06-13" version="1">MAPPRSSRVRPSEVAADTKRNFIPLVKKNYGEMFPPYSYLYRQPIAQLAIQRQKPTTRPPSFRIDVGDPVMQALAYAGMDTQQSEAMGGPRVRIPFICAANERRPGGDWETGCVGYEEKLCRRSNLSATLNTPWPNSPESNNYPIPSQGGIFSDAVVVCRGPHDRYDRLDSWYDLPVVSVPPTRWPKLKDNGLKYSFAEEREMTRDKLRGALRICLYNGYDRVVIGDFGLGNGYRNPPQELAELWRDVFLFDPDLRGQFAYVVFVFEDPQQSTMRHILDEIVKKESGSKSKSRSGSSSSSTTSKSHSNAPTDRQIFEHVFDAAEVDRVLRQPDPRYGLGMITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1S286</accession>
    <name>I1S286_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG10872.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T20679</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325515.1">
        <property type="nucleotide sequence ID" value="XM_011327213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S286"/>
    <dbReference type="STRING" id="229533.I1S286"/>
    <dbReference type="EnsemblFungi" id="CEF88757">
        <property type="protein sequence ID" value="CEF88757"/>
        <property type="gene ID" value="FGRRES_10872"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10872"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20679"/>
    <dbReference type="eggNOG" id="ENOG502SPID">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179461_0_0_1"/>
    <dbReference type="InParanoid" id="I1S286"/>
    <dbReference type="OrthoDB" id="3438962at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF88757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="102" mass="11169" checksum="802A1DDC50E788E1" modified="2012-06-13" version="1">MASIESQESKQGEAPLQNYNEDAEQLATLAEGKVADAVKKTSTRDQPRKDDIKIEDYTSDLDRKKAEQAEAREEIKAQRKAGVDVDGSLGQGRLSNEDSSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I1S3T3</accession>
    <name>I1S3T3_GIBZE</name>
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        <submittedName>
            <fullName evidence="10">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG11480.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T22169</name>
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    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325734.1">
        <property type="nucleotide sequence ID" value="XM_011327432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S3T3"/>
    <dbReference type="EnsemblFungi" id="CEF86853">
        <property type="protein sequence ID" value="CEF86853"/>
        <property type="gene ID" value="FGRRES_11480"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11480"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22169"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="InParanoid" id="I1S3T3"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="MFS quinate transporter"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS_dom"/>
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        <property type="entry name" value="MFS_sugar_transport-like"/>
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    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
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    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
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    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
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    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
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    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF8">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SUGRTRNSPORT"/>
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    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
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            <begin position="104"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF86853"/>
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    </evidence>
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        <source>
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    <accession>I1S4W9</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_011316803.1">
        <property type="nucleotide sequence ID" value="XM_011318501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S4W9"/>
    <dbReference type="EnsemblFungi" id="CEF73112">
        <property type="protein sequence ID" value="CEF73112"/>
        <property type="gene ID" value="FGRRES_11887"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02621"/>
    <dbReference type="HOGENOM" id="CLU_2049887_0_0_1"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF73112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="120" mass="13990" checksum="840AF5483E05D80E" modified="2012-06-13" version="1">MHGRLVLGKLPCDAVRCSHGRYDMASLVFVSVLHKLILSRPGYGSTIAMLRHGFIDHKGQRWRREEKRRWKCIAKVLMQDWAMQADRILGTRQKENRRNGINKWKLGFNGGRLQAYEASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I1S6T6</accession>
    <accession>A0A098DF48</accession>
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        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
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                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322918.1">
        <property type="nucleotide sequence ID" value="XM_011324616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S6T6"/>
    <dbReference type="EnsemblFungi" id="CEF77574">
        <property type="protein sequence ID" value="CEF77574"/>
        <property type="gene ID" value="FGRRES_12559"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12559"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11541"/>
    <dbReference type="HOGENOM" id="CLU_1825394_0_0_1"/>
    <dbReference type="InParanoid" id="I1S6T6"/>
    <dbReference type="OrthoDB" id="3918840at2759"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="141" mass="16221" checksum="7561053A91F99DB4" modified="2012-06-13" version="1">MSLPTTEVACERPKKQLSSSDRATIQNDHYIPQLDPINLQLKHFVYDYMVKHTGPCIATDWQCTVGVTDRMPEILNPITSIMRETRETDYIKFAEPICIFECEVFHNSPTKQAYDGEIDVKMTEFVKRHEDINVASEVVPS</sequence>
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    <accession>I1S761</accession>
    <accession>A0A098E510</accession>
    <name>I1S761_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323593.1">
        <property type="nucleotide sequence ID" value="XM_011325291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S761"/>
    <dbReference type="EnsemblFungi" id="CEF88338">
        <property type="protein sequence ID" value="CEF88338"/>
        <property type="gene ID" value="FGRRES_12684"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12684"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17097"/>
    <dbReference type="HOGENOM" id="CLU_2015500_0_0_1"/>
    <dbReference type="InParanoid" id="I1S761"/>
    <dbReference type="OrthoDB" id="10283303at2759"/>
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        <property type="component" value="Chromosome 3"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF88338.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88338"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="123" mass="14585" checksum="24129B56195E32C0" modified="2012-06-13" version="1">MRNKRSILIGGTDWHEADSRKRQTHQDDVKFPRMRRDKMKDGLMRRRRDRELTVSQKMQRELQLSPFARSLDPELQCKQMIYNATCVGTLSGNKLGRTLLEGQQQDLMYRPWAVIVVQPNNER</sequence>
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    <accession>I1S823</accession>
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        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326509.1">
        <property type="nucleotide sequence ID" value="XM_011328207.1"/>
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    <dbReference type="AlphaFoldDB" id="I1S823"/>
    <dbReference type="EnsemblFungi" id="CEF83487">
        <property type="protein sequence ID" value="CEF83487"/>
        <property type="gene ID" value="FGRRES_12999"/>
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    <dbReference type="KEGG" id="fgr:FGSG_12999"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23339"/>
    <dbReference type="eggNOG" id="ENOG502RJ77">
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    <dbReference type="HOGENOM" id="CLU_1294500_0_0_1"/>
    <dbReference type="InParanoid" id="I1S823"/>
    <dbReference type="OrthoDB" id="5104722at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
    <sequence length="227" mass="24866" checksum="FC2F83DF0FD1AE13" modified="2012-06-13" version="1">MAPPDTSATSSKKTNQSSFKTPKSSQAKKNKKESQPASTSTPRQPDEIEEADTTVPVKTFTPKQKQKQKQVESSEDNDTDDAESVYLSSDEETSSEEDSSDYDSDSDGSVEDLPPRQLARRSTDRGVKSTPSSPFTITQTRSETTRWITTQNNGGMTRGTRSYSEQTTMHGHNTNGPQRAPINRNSVSFNMSINVDMSFNGLVTGRNLGFSGGSLSYAWNRRSTQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I1S8A3</accession>
    <name>I1S8A3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T24131</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326887.1">
        <property type="nucleotide sequence ID" value="XM_011328585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S8A3"/>
    <dbReference type="EnsemblFungi" id="CEF83502">
        <property type="protein sequence ID" value="CEF83502"/>
        <property type="gene ID" value="FGRRES_13081"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13081"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24131"/>
    <dbReference type="HOGENOM" id="CLU_2291943_0_0_1"/>
    <dbReference type="InParanoid" id="I1S8A3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF83502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="101" mass="11123" checksum="BFF264E98DCF12AB" modified="2012-06-13" version="1">MSPGQTKLAPRFGGQAEKKSTPILGTPASWVPAPLEILASVIPEIDMLYIVLHYSNNLEILLPSTSIKAKAPRSSVVGRDLFPRYWSRVPTRRGNTYLSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1S977</accession>
    <accession>A0A098DC87</accession>
    <name>I1S977_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG08260.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T09501</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320540.1">
        <property type="nucleotide sequence ID" value="XM_011322238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S977"/>
    <dbReference type="EnsemblFungi" id="CEF76553">
        <property type="protein sequence ID" value="CEF76553"/>
        <property type="gene ID" value="FGRRES_13407"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13407"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09501"/>
    <dbReference type="HOGENOM" id="CLU_375997_0_0_1"/>
    <dbReference type="InParanoid" id="I1S977"/>
    <dbReference type="OrthoDB" id="5415587at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124829" evidence="1">
        <location>
            <begin position="18"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="795" mass="87335" checksum="87F8D73D026A212A" modified="2012-06-13" version="1">MSLVLSRLGLLVSGGFTVNETASALTVGKIVGSVVSRHTDASLFDAFIQQYGVRFTRLPPWLEDVQFDRSGTILGGQLREIPCQNTIFDVKLRTVEGVATFIVLVARYVESRQQLAKYVEDMIRGKYYIVSGGDLETREKDDLERVSMPYSSRILLQSFVNAVIDADARSPQHDRCRQLLGELTHVVGSAMFQKQTSKHARGQCQRFLQQFLGQRTSISGKPDNIFNTLSAAVAMIALAAMANGAHVRVVCQTSSGSVEIPQGGRTFYNPSIFTVVLWLTEPPMIVSSEMNMVGEEYDLADDDSEPGAIPIYGGAAEISRAIASQTGCGLPDDMARDIWERGVHEGALASWEMGDVLGMRFRLTDETLRCEIPDSLGYLADKLYGERDQRCKIVRKAAAILHDVANYSEYEGFGDSWFNLTLSYVMIAYSVGCLRSAVSVGGNLLSQYCWTSDCELNKDGLRSRLTSEKADALGFVFMIGTTGATIQDFLWRIASVWGGSTTGYHNHVEIHDRVFGIASPHLTLLSDVLRDPKALAQNGLSKGFISVHSGSIPTLPRDPLSGLVIAADASALMEGRFIFDKGPRPLHKETTAGVLFSLEPYTGQDGTLCATICTWQYGEVLLELDPVRVHDNLLAQRSLSSYQRLQGTAYANPNHCFVPLERGEIPVLQRVFMGASWGRSGINSPLTAVLRAEGRLDWQVVVAGIIEGGEMIMACDGESLEEVLTRDPSRDFSGVLIVACRDNVLSQGYIDLIETQKDLASKQSEAEFHCIEFNVNEGPSNSTWSIRKSAPRLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I1SAE6</accession>
    <accession>A0A098DYR8</accession>
    <name>I1SAE6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T21525</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325113.1">
        <property type="nucleotide sequence ID" value="XM_011326811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1SAE6"/>
    <dbReference type="EnsemblFungi" id="CEF86502">
        <property type="protein sequence ID" value="CEF86502"/>
        <property type="gene ID" value="FGRRES_13827"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13827"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21525"/>
    <dbReference type="eggNOG" id="ENOG502SKJK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037768_0_0_1"/>
    <dbReference type="InParanoid" id="I1SAE6"/>
    <dbReference type="OrthoDB" id="5423490at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF86502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="361" mass="40333" checksum="09B1CAD3AD02CD20" modified="2012-06-13" version="1">MAALVDNQMPITQLEDSNDVEAGDDDLGVEVNMSVAGGPYGSFHEPIHESLTLSALISSNSGVSPGTTVKNASNHDWEYIRGSIWNDDPDCQLFDDSVNQNHSYALGAAWYKAYRQGQTDWNPNAMEMNRLRNPIGRSHYGDLQFLHCMASNRGENPDDTKAKIMVWMEVMYKLATGEDGINPDTVVSTTKLSQFCPPMSLPPSWLSLSYYLAKNSNFQGLDIRRRALGSMFHVIQDSYAIGHTKRELMNKDDKVSDNPLKFKQGVADRWGPIVNFHTYFGQDGDSHSHYDHSNDGVPDPSNLGNLEQWNNLIGCRDAADKCKELAERKNAGEKWDSVRDWLDTKVFALSENKTASDSSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1SAS7</accession>
    <accession>A0A098E289</accession>
    <name>I1SAS7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T22045</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325793.1">
        <property type="nucleotide sequence ID" value="XM_011327491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1SAS7"/>
    <dbReference type="STRING" id="229533.I1SAS7"/>
    <dbReference type="EnsemblFungi" id="CEF87739">
        <property type="protein sequence ID" value="CEF87739"/>
        <property type="gene ID" value="FGRRES_13958"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13958"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22045"/>
    <dbReference type="eggNOG" id="ENOG502T091">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_676234_0_0_1"/>
    <dbReference type="InParanoid" id="I1SAS7"/>
    <dbReference type="OrthoDB" id="5093344at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124877" evidence="1">
        <location>
            <begin position="19"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF87739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="407" mass="43854" checksum="062C7401E85ED9DB" modified="2012-06-13" version="1">MKFFSILGLGMIATVVDAAYPNPGNGPADACYTAVAKPNNKQRTSDCKSFLLTTVTPKKSTIYKTTTITRKTPTVTKSITVTSTSSAIDTSISSVVQTVTDNIVVTRTVDHTKTVTEQTTTTITTDVADPAPSVKRKRSVSRIPEYLDNLCTNSAQYSSACSRIGVTAKTVTGPRVTVVSNIVRVKIPRATTVRTTVSTTWVTQTVKTTVILKTYSTEEVTKTIDVVTDDVTVATKTVTETTTKTEAAKPLETVTFFAAGVDDPALGGLGMANIEWRQAGSYYMTFSRDGIQSYTLNKLTGEVKAFNGPSDVIGKSASYSYSPGSGNPFGNAMLQASGAAPLLCKAANGPGYRYLECKFDTNKIADFWLCKQRLVVVYPGYSLSRCYMDGQAYTGYKISYIQIQSVQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-08" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q4HVS2</accession>
    <accession>A0A0E0SIU1</accession>
    <accession>A0A1C3YKA4</accession>
    <accession>I1S2E4</accession>
    <name>GNT1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName>Glucose N-acetyltransferase 1</fullName>
            <ecNumber>2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>N-acetylglucosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">GNT1</name>
        <name type="ORF">FGRAMPH1_01T20841</name>
        <name type="ORF">FGRRES_17495</name>
        <name type="ORF">FGSG_10936</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">N-acetylglucosaminyltransferase involved in the Golgi-specific modification of N-linked glycans.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GNT1 family.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="ESU17817" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="SCB64974" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.4.1.-"/>
    <dbReference type="EMBL" id="DS231670">
        <property type="protein sequence ID" value="ESU17817.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64974.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325439.1">
        <property type="nucleotide sequence ID" value="XM_011327137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4HVS2"/>
    <dbReference type="SMR" id="Q4HVS2"/>
    <dbReference type="FunCoup" id="Q4HVS2">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="229533.Q4HVS2"/>
    <dbReference type="GlyCosmos" id="Q4HVS2">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T20841">
        <property type="protein sequence ID" value="FGRAMPH1_01T20841-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G20841"/>
    </dbReference>
    <dbReference type="GeneID" id="23557813"/>
    <dbReference type="KEGG" id="fgr:FGSG_10936"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20841"/>
    <dbReference type="eggNOG" id="KOG1950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034860_2_1_1"/>
    <dbReference type="InParanoid" id="Q4HVS2"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000087535" description="Glucose N-acetyltransferase 1">
        <location>
            <begin position="1"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Signal-anchor for type II membrane protein" evidence="2">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="36"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DXD">
        <location>
            <begin position="258"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="450" mass="52390" checksum="D87E8DED8A0A13C1" modified="2016-09-07" version="2">MGEASSFVAVRLMRIIPILAILGATYYIFLTCFASFQATDVPVPEEWRNHDAVVDEVDEITETLTHDPDSRPTPHKLTIAEIEDLENKGEFMGFEDEDEIDVFINLDDDGDWEEDDLKKELGDELEGDFEDEEDEDFGDDDDDDDNDDDVDWSRFAYIQYVTNEDYLCNSVMIFEQLHRLGSKADRLLMYPKEMLEPDAAYSNKRGGQLLIRARDEYNVTLQPIEIQHRDGQDETWADSFTKLLAFNQTQYDRVLSLDSDSMVLQHMDELFQLPPCPVAMPRAYWLYNENPPKRILSSQVMLIQPDDVEFERIVQKMNSIGPNDYDMEIVNSLYLDSALILPHRKYDMLTAEFRNKDHTAYLGSEREKWDSSVALSEAKFVHFSDWPVPKPWINDVETRLANQPDCPEGETSCPDRDIWNGFYTDFTDNKKRVCESVGKTGQKWIHWRRM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q4HZ95</accession>
    <accession>A0A0E0SH02</accession>
    <accession>V6RP31</accession>
    <name>TIM21_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial import inner membrane translocase subunit TIM21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TIM21</name>
        <name type="ORF">FGRRES_09713</name>
        <name type="ORF">FGSG_09713</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS231668">
        <property type="protein sequence ID" value="ESU16328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327988.1">
        <property type="nucleotide sequence ID" value="XM_011329686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4HZ95"/>
    <dbReference type="SMR" id="Q4HZ95"/>
    <dbReference type="FunCoup" id="Q4HZ95">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="229533.Q4HZ95"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T26449">
        <property type="protein sequence ID" value="FGRAMPH1_01T26449-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G26449"/>
    </dbReference>
    <dbReference type="GeneID" id="23556650"/>
    <dbReference type="KEGG" id="fgr:FGSG_09713"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26449"/>
    <dbReference type="eggNOG" id="KOG4836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089407_0_0_1"/>
    <dbReference type="InParanoid" id="Q4HZ95"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.320:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000043145" description="Mitochondrial import inner membrane translocase subunit TIM21">
        <location>
            <begin position="32"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="2">
        <location>
            <begin position="32"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="2">
        <location>
            <begin position="98"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="229" mass="26006" checksum="97E68FC87CBFC728" modified="2005-08-16" version="1" precursor="true">MNPTTNLLVTRSTAFRGVPTTLRPFLASRYYATQQGLGATPRGPKRRAVTPFNDNGHVPWKQLSVAEKAARATQQSFNFGMILVGLMLTGGVGYFLWTDVFSPDSKISNFNRAVDKIRSDPRIIDVMGDSKKIAAHGDETFNKWRRARPVASSETTDARGDQHIMMHFYVEGPKNNGVARLHMIKYRGHSDFEYKYLFVDVKDHERIYLEHEDSSSKNGKKFSLFGVKW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-20" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q4IJT0</accession>
    <accession>A0A0E0RUB3</accession>
    <accession>V6R028</accession>
    <name>ALG8_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.265</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Asparagine-linked glycosylation protein 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ALG8</name>
        <name type="ORF">FGRRES_02528</name>
        <name type="ORF">FGSG_02528</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the second glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(1)Man(9)GlcNAc(2)-PP-Dol to produce Glc(2)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31307"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19521"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132521"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="EC" id="2.4.1.265"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:31308"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.265" evidence="1"/>
    <dbReference type="EMBL" id="DS231663">
        <property type="protein sequence ID" value="ESU07978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318463.1">
        <property type="nucleotide sequence ID" value="XM_011320161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4IJT0"/>
    <dbReference type="SMR" id="Q4IJT0"/>
    <dbReference type="FunCoup" id="Q4IJT0">
        <property type="interactions" value="793"/>
    </dbReference>
    <dbReference type="STRING" id="229533.Q4IJT0"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T06067">
        <property type="protein sequence ID" value="FGRAMPH1_01T06067-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G06067"/>
    </dbReference>
    <dbReference type="GeneID" id="23549899"/>
    <dbReference type="KEGG" id="fgr:FGSG_02528"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06067"/>
    <dbReference type="eggNOG" id="KOG2576">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022045_1_1_1"/>
    <dbReference type="InParanoid" id="Q4IJT0"/>
    <dbReference type="OrthoDB" id="1689333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000278334" description="Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase">
        <location>
            <begin position="1"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="4"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="26"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="276"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="377"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="468"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="494"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P40351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="501" mass="56916" checksum="9E8B755EDEC2C834" modified="2005-08-16" version="1">MSEHYPTLAQTALVAAAFKILLFPAYKSTDFEVHRNWLAITNSLPLEKWYVEKTSEWTLDYPPFFAYFEWILAHVARLVDPLMVKVYNLDYDSWQTVYFQRTSVIVTELVLVWALQTFIETAPLKSRRAAQTVALSIILSPGLLIIDHIHFQYNGFMYGILVMSLVLARQNSELLSSGLIFAALLCFKHIYLYLAPAYFVYLLRAYCLSSKSIFRIRFLNSIKLGLGIGAIFGAAFGPFAAMDQIPQLLSRLFPFSRGLCHAYWAPNVWALYSFADRILIHVAPRLGWAVNKSALQSVTRGLVGDTAFAVLPEISPRTCFVLTLFFQVVPLIKLFFQPTWETFIGAVTLCGYSSFLFGWHVHEKAILLVIIPFSLIALRDRRHLGAFRPLVVAGYVSLFPLLFTPAEFPIKTIYTIVWLVVFLLAFGRLAPASNKPRIFLLDRFSTLYIAISIPLILYCSLLHHLIFGKAYEFIPLMFTSSYTAIGVVGSWVGYMVVYFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>V6QYF0</accession>
    <name>V6QYF0_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG01386.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T03411</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317182.1">
        <property type="nucleotide sequence ID" value="XM_011318880.1"/>
    </dbReference>
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        <property type="interactions" value="846"/>
    </dbReference>
    <dbReference type="STRING" id="229533.V6QYF0"/>
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        <property type="protein sequence ID" value="CEF73511"/>
        <property type="gene ID" value="FGRRES_01386"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01386"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03411"/>
    <dbReference type="eggNOG" id="KOG2423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011106_4_0_1"/>
    <dbReference type="InParanoid" id="V6QYF0"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000200">
        <property type="term" value="P:regulation of ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="224"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="474"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="483"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="602"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF73511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="618" mass="68489" checksum="B3877E9F809A9014" modified="2014-02-19" version="1">MGTGKKEASRRERQGKGGDGLNNVKTKGENFYRDAKRVRQLNILKEGKAQRNADGEITKAASFQSRDIPNARIEPNRKWFTNTRVISQDSLNAFREAMDEQARDPYQVLLKTNKLPLSLISDGKNVNTENGIKQHKAKMTVETSPFAEVFGPKAQRKRVKLGVSSLDDIIGDTEKSMDTYRDRLEQQKLLSGASGDAEDLDDAGKPLTMAIEPVFDKGQSKRIWNELYKVIDSSDVIIHVLDARDPIGTRCLSVEKYLKEEASHKHLIYLLNKVDLVPTSVAAAWVRTLSKEHPTLAFHASINNSFGKGSLIQLLRQFSSLHSDRKQISVGLIGGPNTGKSSIINTLMKKKVCTVAPIPGETKVWQYISLMKRIYLIDCPGIVPPSTTDTPTDLVLRGVVRVEKVEHPEQYIQSLLNRVKKHHMEKTYELKGWDNSTEFLELLARKAGRLLRGGEPDLDGVAKMVLNDFMRGKIPWFTPPPKSEGEADTKVGNREGRLGEMPRKRKQEEAVDDEDASAEAQLQREAEAALEKAGGESAGEESDFEGFGSDTEEARSRKPSFGATIDGESEVESAEDDVISVGGSEEVEEEEEQKAPASAAKSKGKKNKGGPPSKKRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>V6R9P0</accession>
    <name>V6R9P0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG05194.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T17335</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323702.1">
        <property type="nucleotide sequence ID" value="XM_011325400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6R9P0"/>
    <dbReference type="FunCoup" id="V6R9P0">
        <property type="interactions" value="544"/>
    </dbReference>
    <dbReference type="STRING" id="229533.V6R9P0"/>
    <dbReference type="EnsemblFungi" id="CEF87920">
        <property type="protein sequence ID" value="CEF87920"/>
        <property type="gene ID" value="FGRRES_05194"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05194"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17335"/>
    <dbReference type="eggNOG" id="KOG2174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134810_0_1_1"/>
    <dbReference type="InParanoid" id="V6R9P0"/>
    <dbReference type="OrthoDB" id="14246at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF87920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="128" mass="13791" checksum="42F5B709F1D1BC4F" modified="2014-02-19" version="1">MSAGLKTIIALSFVLAVGFLLVILSCALWKVYYPLLVVATYVIAPIPNWICGHCANPDDFVESSGAAVLDLGRFFTGFFVVMGIALPVVLAHSGLIEVQAMVMSIIGGLLIYGTIVSFGMFFHEEQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>V6RPS5</accession>
    <name>V6RPS5_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">FG09834.1</name>
        <name evidence="16" type="ORF">FGRAMPH1_01T26169</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327850.1">
        <property type="nucleotide sequence ID" value="XM_011329548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6RPS5"/>
    <dbReference type="FunCoup" id="V6RPS5">
        <property type="interactions" value="959"/>
    </dbReference>
    <dbReference type="STRING" id="229533.V6RPS5"/>
    <dbReference type="EnsemblFungi" id="CEF85274">
        <property type="protein sequence ID" value="CEF85274"/>
        <property type="gene ID" value="FGRRES_09834"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="organism ID" value="2428"/>
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        <property type="component" value="Chromosome 4"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
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        <property type="entry name" value="TPP_PDC_IPDC"/>
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        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
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    <dbReference type="PANTHER" id="PTHR43452:SF30">
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        <property type="entry name" value="TPP_enzyme_C"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="11"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="206"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="404"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CEF85274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="570" mass="63011" checksum="68C0B7F5289BD308" modified="2014-02-19" version="1">MSNSSLQKPIDVAEYLFKRLYEVGVRSIHGVPGDYNLVALDYLPQCNLRWVGSVNELNAAYAADGYARVTKMAALITTFGVGELSAINGVAGSYSEHIPVVHIVGCPSTISQRDQMLLHHTLGNGDFDVFANMSSQISCNVAKLNKPSEIAEQIDTALRTCWLRSRPVYIMVPTDMVQEKVEGARLDTPIDLSEPKNDPGNEDFVVDEILKAMYAAKRPVILVDSCAIRHRVVEEVHQLVDKLDLPVFVTPMGKGAVNEDHPNYGGVFAGDGSHPPRAQTIVEESDLLLTIGALKSDFNTTGFSYRTSQINSVDFHSTHCKVRYSTYPGVAMRGVLRKIIDKVDPKSMPAPSIPEVRNEVEKNNDDSETITQAWFWPRVGEYLIPNDIVVTETGTANFGIWDTRFPRNVTALSQVLWGSIGWSVGACQGAALAAKDAGKDGRTILFVGDGSFQLTAQELSTMIRHGLKPTIFVICNDGFTIERFIHGMDAVYNDINNWKYKDLVSVFGGEKTCKTFQIKTKNELNELLTNKEFNAAECLQFVELYMPREDAPRALVLTAEASARNNAKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D1C6</accession>
    <accession>A0A0E0RLX2</accession>
    <name>A0A098D1C6_GIBZE</name>
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        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T00889</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D1C6"/>
    <dbReference type="EnsemblFungi" id="CEF72247">
        <property type="protein sequence ID" value="CEF72247"/>
        <property type="gene ID" value="FGRRES_15063"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00889"/>
    <dbReference type="InParanoid" id="A0A098D1C6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF72247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="68" mass="7283" checksum="C84571C80AE3434B" modified="2015-01-07" version="1">MGFLAKAGLSGRLKVAGYEHMAIPCWQDIAPVEPISGDTVSIWSSSGDSATIDLVLTASEKLLCMTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D9S9</accession>
    <accession>A0A0E0RWS9</accession>
    <name>A0A098D9S9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T07801</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D9S9"/>
    <dbReference type="EnsemblFungi" id="CEF75704">
        <property type="protein sequence ID" value="CEF75704"/>
        <property type="gene ID" value="FGRRES_15593_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07801"/>
    <dbReference type="InParanoid" id="A0A098D9S9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF75704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="88" mass="9629" checksum="BA8B1850A2740C8B" modified="2015-01-07" version="1">MTREKKKKISAYGQLDNNYINHPCKYSRARVASQRGRPSTARGVLVACPFSLSTYKGVAVNYQGGSRVSRPSPCLHIARLVSNSTGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DBS2</accession>
    <accession>A0A0E0RW01</accession>
    <name>A0A098DBS2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T07243</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DBS2"/>
    <dbReference type="EnsemblFungi" id="CEF75426">
        <property type="protein sequence ID" value="CEF75426"/>
        <property type="gene ID" value="FGRRES_20089"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07243"/>
    <dbReference type="InParanoid" id="A0A098DBS2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF75426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="69" mass="7591" checksum="FD4D78EF4E9D637E" modified="2015-01-07" version="1">MARGTGICSVPDNVLTNGAMFGLLSRHVIHNQLETLFCPFYMTRVRTWALRGGLYVAVSSNLDNGAVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DD16</accession>
    <accession>A0A0E0RYK7</accession>
    <name>A0A098DD16_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T09059</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DD16"/>
    <dbReference type="EnsemblFungi" id="CEF76332">
        <property type="protein sequence ID" value="CEF76332"/>
        <property type="gene ID" value="FGRRES_20115"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09059"/>
    <dbReference type="InParanoid" id="A0A098DD16"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF76332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="103" mass="11172" checksum="B22E339B3E24B32E" modified="2015-01-07" version="1">MVTITILDAVSVTPPVLRQPDAASSFLPHLPTAIAFARPTINTFSITSPQVSNPANTTFPTGEQAVIHIVIVDILAIFEKLSGYLHPVVTWIEIELISKLPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DD55</accession>
    <accession>A0A0E0RXA6</accession>
    <name>A0A098DD55_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG10459.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T08155</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DD55"/>
    <dbReference type="STRING" id="229533.A0A098DD55"/>
    <dbReference type="EnsemblFungi" id="CEF75881">
        <property type="protein sequence ID" value="CEF75881"/>
        <property type="gene ID" value="FGRRES_10459_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08155"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DD55"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide synthase-like phosphopantetheine-binding" evidence="4">
        <location>
            <begin position="542"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF75881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1094" mass="120065" checksum="3B4A81A0C9E60033" modified="2015-01-07" version="1">MTVEQSTEAKCLTLDSIIRGLAGNTQTILSYATTNDDFANFTGSDIERLTIIGANIYLQALKAQSDFDLKAAKSKVVIALIGTSTLEYYITFLSIQRLGFTTVLLSPRLTHEGVAHLLNVTECCAAIVPESHRAMFDKIPLCIVPMIRDVFALVGQVWSPIPELECHSLDQTPGVVVHSGGTTSGLPKPISAPSGAWIAAVAGTDAKSHRLHTLPTFNTMPLYHTFGLGVLFRALRMGTRVSLLNSDRPLVAEAIFRGIDATESRCLTTVPYVLKFLAEEVGGVEKLAKLDFVSVGGAAVPDDLGQSLIDAGVSLKTTYGQSESGILMLPVIDEDKQWGWLEPMEHAEQYMRFEPAEGDLYHLVILPGLASKTMSDRPDGSYGTKDLFEKHPHKPRTWKFVARHDDMIVLSNGENANPVPLENSLMNNPNVVMAAAFGAGQESLGAIIIPSAHASNLAHEDLLKSIEPDLNLGNARMPAYARVSLDAVLIQPADTELPMTGKSTLQRALFYRQFSTIISDYYSNGGVHNTLGKLPEHPFDDAEISRIVHEIVLRHHPPMKDNRDGDFFTMGMDSLQASRIRAEILRRIYIKPEKVATNVVFNHPNLSLLSNHIVSLYTGRQDAMTVDPQEIARSFIRKYTRFTTKEGTEKQGMSSVPEANTILLTGATGYLGVQILHNLLSRRPKDRVYCLIRAQDNAEAELRLGQALVSSKLTLPKQLRERAVALAGDLGRDRLGLHLDDYGTLLRSVTKIIHNAWAVNFSMSLSSFEPQLAGVCHLIKLALSAQKTPEVVFISSIVAVASANPPAQSSASCEPTQWKGNIAERRYGWEAVSSLGYGQSKWVAEEICYSASEHTRLPVKVIRLGQISGDTHHGIWNPSEAVPTIILSALTAGALPRIEADNVFRVGDAQLWIPSDVAAASIVELTFSEVGEGIPSCEADGASTHSDIPKILEKIPYTVFHVSGYHPVSWNADIVPLLRNFGLEFEVVSQRAWVDKLASSDSDVSRNPPYKLIEFFKGGTQIEDQLDPVGTRTSSAQVHLDTSLASKYAPSLAQLGSLDEKLMRKYLEYWKKESWQKLERDLVMEGHKKEMGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DDT2</accession>
    <accession>A0A0E0RXZ1</accession>
    <name>A0A098DDT2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T08627</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF76116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DDT2"/>
    <dbReference type="STRING" id="229533.A0A098DDT2"/>
    <dbReference type="EnsemblFungi" id="CEF76116">
        <property type="protein sequence ID" value="CEF76116"/>
        <property type="gene ID" value="FGRRES_17422"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08627"/>
    <dbReference type="InParanoid" id="A0A098DDT2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050114">
        <property type="entry name" value="UPF0173_UPF0282_UlaG_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546:SF3">
        <property type="entry name" value="UPF0173 METAL-DEPENDENT HYDROLASE MJ1163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546">
        <property type="entry name" value="UPF0173 METAL-DEPENDENT HYDROLASE MJ1163-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="303" mass="33514" checksum="AFE5285EF9002F8F" modified="2015-01-07" version="1">MTNSTLEWFGATTYRLRTRGVTIFLDTWLDRPSVLETYLPVDDVQEADYIFISHAHFDHLPGADRIAIKTGAIVIANNEAINLLREAGVPDHQLFPVQGGERIPLFTRETWDQARADPSLFSPGLPNAPNRPLDKLAALSVDVWPSLHCFMPADHPEVIDTATVYKGTASPYSCTLDITIGMKYGLFQLGELMPPEKLTPGHRSFIEYVSDRKRNVMSHCDGGQLMFNFVIGNKALLWSAHLGGYDGILKNLQPKPDIAIMAIAGRANLNGRPFDGSAAEFAAMKVGWLGNPSQVIWCLHDEA</sequence>
</entry>
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    <accession>A0A098DE66</accession>
    <accession>A0A0E0S183</accession>
    <name>A0A098DE66_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T10911</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DE66"/>
    <dbReference type="STRING" id="229533.A0A098DE66"/>
    <dbReference type="EnsemblFungi" id="CEF77258">
        <property type="protein sequence ID" value="CEF77258"/>
        <property type="gene ID" value="FGRRES_16965"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10911"/>
    <dbReference type="InParanoid" id="A0A098DE66"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="154"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="908" mass="103428" checksum="B04A931B2D1DC0C2" modified="2015-01-07" version="1">MDWHDPDCRRIDPIPFDDKLWTCQACGTIGPLEFSIDEPAEAVTSSAHHEETHSKEEIKPLSWPSCVDYITDAPSEDIGRVLQQIQASQGMVCSGITHQAATVSDAYGREIQQVEYPKLTQPSHIRILELLPAPREKALEGRLLVVDVDKPPAYEALSYTWADASNDSSLCQRIFIGHGNRALPITSSCHQGLRHLRKELESVFIWVDSVCINQSDLEERSYQVAMMDDVFSRANVVHAYVGEDEYGNSRKGTKAVPLLQSITEPTRPPGREFKNHAPAILDPFFQRPFFSRLWVVQEVLLARSVVLHCGDKFTPISQDMVVKAQTHRVEIPWWMNHIGRIGPYVKSELVQVLAATALCQMSDLRDKIFGLLGLVDVEDASILAADYNLMVREVYIGTAAYLIQKRGRHEILELSESLTNIEQRNTYGIPSWVPMWDLQQRPYVAADISQRLGDIQTVMNEASARIPALSLPTWPSSQPIWNRSAKSIRKNIPLSTCEAETDSALEECYKAVDSETGCLVTSGYDVAELKRSDFIKLLKTATFDEVHREVHYKAIRQGEVTLAVSGPISTLRSTPQRILGPSDYLALVRIFGCKTFFVCDKYIRDNNVITYKLVYPCAVAIIYWIGKQHIYSKHTDFDRACILEATYPLTLEIITFLYQWRYLMLPREEGLATCNSTDSFLVKERENATNLYVRYAVVVEIESPSASEDEITAWRLQLEEDPNWTSRHESSLVDDFFTELLDLQSFWDAGRFEELANLDLKTAQDDLNYCNGVLDTFATTDRSDKQSHRRKEKPGKVEAELSSWKAAWGLLFKRFNGLISVALKEEVNMFPQTVDDIFELPESWLGAYKNKQELVRLLEDRWMRCTRLLSFVIESAQCFEEAKQVMEGRREILGMFGVGREDERIVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DEQ8</accession>
    <accession>A0A0E0RYU6</accession>
    <name>A0A098DEQ8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
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    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T09237</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DEQ8"/>
    <dbReference type="EnsemblFungi" id="CEF76421">
        <property type="protein sequence ID" value="CEF76421"/>
        <property type="gene ID" value="FGRRES_15465_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09237"/>
    <dbReference type="InParanoid" id="A0A098DEQ8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="48" mass="5457" checksum="4E19730A14470082" modified="2015-01-07" version="1">MSYSPFQPQLCHRFLKKAEAEQRHMGPHGIVSIGCPSRRTSNYQSHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DGI2</accession>
    <accession>A0A0E0S237</accession>
    <name>A0A098DGI2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG02876.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T11517</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DGI2"/>
    <dbReference type="STRING" id="229533.A0A098DGI2"/>
    <dbReference type="EnsemblFungi" id="CEF77562">
        <property type="protein sequence ID" value="CEF77562"/>
        <property type="gene ID" value="FGRRES_16375"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11517"/>
    <dbReference type="InParanoid" id="A0A098DGI2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37157:SF2">
        <property type="entry name" value="EB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37157">
        <property type="entry name" value="PRION-LIKE-(Q/N-RICH) DOMAIN-BEARING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF77562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="729" mass="77713" checksum="13370563B07FF889" modified="2015-01-07" version="1">MTRLRDVAVIFASSVALAQDPQQVLNGGSRLLTTPLGTQVNTLGSCLMGSACQRVGKKITIDDIVISTDGQGNTKCCPLGTTFNGSRCVYPKSTVCPPNMHFANGVCVLTSGPVCEDTNLVPTKDGCASKVPPRCPPETILDNGQCVMKEDPTCPGGKKIVNGLCTVDEVPKCPEKGFRAQGNLCVSDEGPTCHQDWLKVVDGKCVHTKEASCPPGTKQSGTGRCISVQPPSCPPGFTVSGNTCLHDTGPSCPSGSTFRNGVCEYSRLPSCSEGTLTNGVCVSSSQPGCPSGFKFDKVTARCLRRDQLNCQAGYVNRWDRVSDKVACCPKDFGGFDGTFCTQDNPGSNACPVNSELRDGKCVTSPGGQPDCDGGKGFVEKGVCYKKEEASCPTPLKVFKDKCVYETDPHCTDGKLSPSRMECIVEGPNCPNDSTVVDDECVSNVHIPECPSNLKRKDGSCVGEPTLSCPPGSVKNGDYCIYDNVQPACKDGLLLLGNQCVTRTTAKCPEDTMPEGEYCVSMKNPICPEPEYIYSLARRACIYKYRPSCLPPFYLKNERCVIDTEPTCPPDTVRSGDSCIKRANCSGDYTLVGDRCVHNRSPECPDQSTELDEKTGQCISRSETPKCTDGSVLTNGKCVVRADCPPNTTPMGDYCVSYQKPACRDGFTLENGECVLKKGPACPPGFAARGTECFSTKQPVCPTGSIQDGDRCIIGVNPDCIILGTCPEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DHM9</accession>
    <accession>A0A0E0S362</accession>
    <name>A0A098DHM9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
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    <gene>
        <name evidence="4" type="primary">FG03188.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T12267</name>
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    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DHM9"/>
    <dbReference type="EnsemblFungi" id="CEF77937">
        <property type="protein sequence ID" value="CEF77937"/>
        <property type="gene ID" value="FGRRES_16312_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12267"/>
    <dbReference type="eggNOG" id="KOG4388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DHM9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010018687" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="1016"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="308"/>
            <end position="336"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="368"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="372"/>
            <end position="486"/>
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            <begin position="487"/>
            <end position="502"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="529"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="772"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="885"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF77937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1184" mass="115439" checksum="0D873F6E3A3A041F" modified="2015-01-07" version="1">MRSFVAFAALALSAADLATAGPCKPRPTTTDAASTVDTSATLNPTATLGTSATLDASATLDPTATLDATETTAGADATTLPDPPTNKPIENSCTGGGMTDLSAFNKVGDVKPNGQDGFTKDGSRDTSCAQLTAKSTGPTRKRQDAGDVATLGQDLSGLDTRTKYTVQFWYRIATAPTRNNDCTLEAYIGSLRFFNTAIFANDASDSYIQVLTSTTVPASQGELNFKTTCANGDSASVLIDSVFMSNQVTPENIDNYRLDFGDGQIREPTNSPATTAGTQLPPTTQPAAATTTSAAGNGGNGNNSAQPTSADQSDATTQGNSESTETGAIKPTTASQDGEETSQPTQGSGSQSTSVADGGSSATTSAAGNDGDATTQTQGSQPTSVTQGSGSDATTQSEGSGSQPTTVSQGSDVTSETQGSGSQPTSATQASESDATTETQGSGSQPTTVSQGSDATTETQGSGSQPTSATQGSGSDVTTASSDFAETQTASSQGTQSSAPASEQTEATSVPTTTAASENESSQSTSAPVVDEAVTTTTAAGTDSASAAASESTSAAGIESSSAAGSESSSVAVDESATTTTAAAGSESSSAAVSEAATTTTAAAGSESTSAAGTDSASASASESTSAVGIESSSAAGSESTTAAVSDAATTTTAAAGYESTSAAGTESASAAVSESSSTAVDDAATTTTAAAAGSESTTAPVDEAVTTTTAAAGTDSTTEPAGSESTTAAADSESTTVSVDSASTTAATGSGSTTAAVDEAITTTTAGADNESTTVATGSESTTAAGTESASAAVSESSSAAVDDAATTTAAAAGSESTTAPVDEAATTTTAAAGTGSTTVPADNESTSASASESVATTTTAGAESTSATVGDGSATTTTAPVDTESTSAPVSESTAATTTATAGTESVITTTTAAAGTESTSAAASTESASDTVSESVTATATATTSDSATTTDASVASESATTTDASVSESLITTTTAAGTESSSAPTTTEASATSSGTPDETTSTSSSEPTQAFVARAEPARTKCLSTSNSVANGDFDNGAADWTFSGSATAVDDKGHGPKAYTIGSYGVGFIGPATGSFSQTISDLEVGENYYLSYAYYVDSDASLPDNECTVKVTFDSAEVETFDPFSESEARDGFRNRVFQVAPDAASSDLSFELSCNNNPDAFNLMVDDVYLVRCDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DJL5</accession>
    <accession>A0A0E0S575</accession>
    <name>A0A098DJL5_GIBZE</name>
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        <submittedName>
            <fullName evidence="7">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG03782.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T13695</name>
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    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DJL5"/>
    <dbReference type="STRING" id="229533.A0A098DJL5"/>
    <dbReference type="EnsemblFungi" id="CEF78650">
        <property type="protein sequence ID" value="CEF78650"/>
        <property type="gene ID" value="FGRRES_16205"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13695"/>
    <dbReference type="eggNOG" id="ENOG502SJ3M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DJL5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF9">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="68"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF78650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="500" mass="55349" checksum="2D5D0A0A9DD8D00E" modified="2015-01-07" version="1">MEFIAAGTAWALNRAPSPQKILSRLGLASLVVTNTWSELSSKLSPNASIVFPDDPEFSGLVSRWRDWHAPQVGAVVTAFTENDVQEAVIYANRNGIPFLARSGGHGATEALQLAKDALVVDIRGMNDIKVAPDGNYATISGGASVKKVVNELWTSKKQTVTGICECVGISAPVLGGGHGWLQGQYGLASDQVISARVVLPNGEAVTASEESNPDLFWALRGAGHNFGIVTEWEYRIYDVKNPNWSYEIFIFLGDKLEEVLELTNKMMKTQPPEIIHWMYIVNIPEIDPHKPIIWYAIISDSPVNEAREYAKPLHEMGPLNVNAGAVPMPELAHITLMSEDTVGCTKGFTGLRYPIGLKKYDPPAVRQVYDSIAEISHRIPELAGSFFLLEGYSTHGVKAVDASESAFPHRDDEILVTSYVLYKPNATLDSLAQEHGEKLRGLLQEASDEPERLRAYVNYAHGVESLESMYGYEPWRINKLKALKKKWDPENRMRFYAPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DK33</accession>
    <accession>A0A0E0S5P2</accession>
    <name>A0A098DK33_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T14029</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DK33"/>
    <dbReference type="EnsemblFungi" id="CEF78817">
        <property type="protein sequence ID" value="CEF78817"/>
        <property type="gene ID" value="FGRRES_20186"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14029"/>
    <dbReference type="InParanoid" id="A0A098DK33"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF78817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="98" mass="10952" checksum="08E730EBA0181978" modified="2015-01-07" version="1">MACQTQSSMREGDTNHPDILLPRVCRSTKKNWRKVSIDIGDRHPNLGNRDKVDSSTVLSAYGLTGVYGDSGRKASVSNFNCHLPHEMDKDYAMIKSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DMK7</accession>
    <accession>A0A0E0S870</accession>
    <name>A0A098DMK7_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">FG04648.1</name>
        <name evidence="17" type="ORF">FGRAMPH1_01T15793</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the secreted LysM effector family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DMK7"/>
    <dbReference type="STRING" id="229533.A0A098DMK7"/>
    <dbReference type="EnsemblFungi" id="CEF79695">
        <property type="protein sequence ID" value="CEF79695"/>
        <property type="gene ID" value="FGRRES_16080_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15793"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DMK7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
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        <property type="entry name" value="Glyco_hydro18_cat"/>
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        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
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        <property type="entry name" value="LysM"/>
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    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
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        <property type="entry name" value="LysM_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00704">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="11 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="LysM" evidence="15">
        <location>
            <begin position="111"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="15">
        <location>
            <begin position="175"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="16">
        <location>
            <begin position="297"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
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            <dbReference type="ARBA" id="ARBA00023024"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CEF79695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="657" mass="71905" checksum="50B2D7C00E7AB79C" modified="2015-01-07" version="1">MGSIAATTILEHFEKVASEGTQIMQACDINPMNPYTFGVFAIDKISDFELVRKHVQTWTSGYCAAMPLTRPKDVRTQVNIPGGDLFMGSSNATSVAQSGLPTDREARAECKTTKVGDKDTCTTLTIRCNIRGADFVKYNTKQNLCSTLKVGQLVCCSSGTLPDNTPKPDSDGTCATHKIDTGDTCASFAATSGITVKDIETYNKKSWAWAGCNRLQMGQVICLSSGNTPMPSTHEGIACGPQKPGTKRPSGSFDGWDLAKLNQSDTKAPGAFKLKTNGCISNCGTDIVNNKSPPKEFKRIGYFQAYNPSRPCMNMDATEIAENFEELTHVYFTFAGITADYDVNISDDVKKQFEIFDKMDAPFKKILSFGGWAESTDAATFQRYRDVHSSFDGVDIDWEYPGATDQGIPAGDRTDGLYYYPFLSVLRNLLPSSKSLSIALPGSYWYLNPFPVDQMAEVLDYFVFMTYDLHGQWDYGNKFANPGCDNGNCLRSHINRTETRTSLSMITKAGVPAEKVIVGIASYGRSFRMADNSCTGPDCLFTGSFEESEAEPGQCTGTGGYILNAEINEIWQLTCCYLRRLGLVNSFSVRDGAAGVPSWNSSLTWHGRSASHANYTLGVGPLKQGGSQTEMDDCVVFINHIFDAMPNWYKTLSLGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DPB3</accession>
    <accession>A0A0E0SB52</accession>
    <name>A0A098DPB3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T22527</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DPB3"/>
    <dbReference type="STRING" id="229533.A0A098DPB3"/>
    <dbReference type="EnsemblFungi" id="CEF83665">
        <property type="protein sequence ID" value="CEF83665"/>
        <property type="gene ID" value="FGRRES_16672_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22527"/>
    <dbReference type="eggNOG" id="ENOG502T9ES">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DPB3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="522"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF83665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="580" mass="65391" checksum="447EE44E699B6DE7" modified="2015-01-07" version="1">MSSISESSVRRACESCRRKKTKCTGEKPICSFCERLHQDCVYLPRNRETVRRKRRASRSDRVVNYDGQDINELLGPGAASSSAGSVFTPDSLPRQRNRRVPTVERTPRRIGRITIHDEPSGSWSSPLPEVTPSPTSLDNAVDEYRGRLYFQPLPLFDPQGLRERIQRSPMFLQWIFLALALSNLPYDASSAKEADLIHSHARAARDTVLELAMRGTARLEISQALCLLALGDILEGRPALALMTIGAVCRLELVRGAGYAESPSDASLRCYWSVFILEKGFTPRFTLLSQTHSKPEYPRSAREPSPPAYIGDEEYAPDLVTIRDDLRTDPGITSHAVRAVSFCGDVISYLHALRIGKADNPADTNSNFYQLTNTLYDLESQLGHIHFVRNVGFSERTSEEFERHREYWAPWLLFQMTAHASQALLNHPFIHLVLLRRANRPSQPRLFLQQTVDQAMFHSAWVTRLVQTCMDRGLMVYDPLIGDLVAATATIPWLFQYARDTKVSETSKENYRKCIDFLESMPDPSPRTRTSTSVTKHVQPSARQQHDKFPAVQDLAAHRYGYNGRCGAAADERRSGGEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DPC3</accession>
    <accession>A0A0E0S9U9</accession>
    <name>A0A098DPC3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T24239</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DPC3"/>
    <dbReference type="EnsemblFungi" id="CEF83212">
        <property type="protein sequence ID" value="CEF83212"/>
        <property type="gene ID" value="FGRRES_15417"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24239"/>
    <dbReference type="InParanoid" id="A0A098DPC3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF83212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="62" mass="7079" checksum="CFC11D6FF74ADEB5" modified="2015-01-07" version="1">MTSQSYFHGKLPLSGIRWPNNFILYAFSGQFFWNPKAKIGTALRDQMCGQHIATVDPVYKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DPS3</accession>
    <accession>A0A0E0S8W0</accession>
    <name>A0A098DPS3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG07241.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T24323</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF82873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DPS3"/>
    <dbReference type="FunCoup" id="A0A098DPS3">
        <property type="interactions" value="1262"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A098DPS3"/>
    <dbReference type="EnsemblFungi" id="CEF82873">
        <property type="protein sequence ID" value="CEF82873"/>
        <property type="gene ID" value="FGRRES_07241_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24323"/>
    <dbReference type="eggNOG" id="KOG1487">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DPS3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17230">
        <property type="entry name" value="TGS_DRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="86"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="312"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF82873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF82873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="389" mass="42607" checksum="167CE62CA004456B" modified="2015-01-07" version="1">MATTVDKVRSRSHLQTALGTSLLTPVPHQIKDIEAEMAKTQKNKATSFHLGQLKAKLAKLKRELLTPSGGGGGGGTGFDVARTGVASIGFIGFPSVGKSTLMSRLTGQHSEAAAYEFTTLTSVPGQVVYNGAPLQIIDLPGIIEGAKDGRGRGRQVIAVAKTCHLIFIVLDVNKPLTDKRVIEAELEGFGIRINKEPPNITFRKKDKGGLNVTSTVPLTHIDHGEIKAVMSEYRINSADITIRCDATVDDLIDVLEAKSRSYIPVVYCLNKIDSISIEELDLLYRIPNAVPISSEHGWNIDELMEAMWDKLSLVRVYTKPKGKQPDYSQPVVLRATRCTVEDFCNAIHRSITEVFKTAIVYGKSVKHQPQRVGLSHELCDEDVVTIVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DQ62</accession>
    <accession>A0A0E0SC32</accession>
    <name>A0A098DQ62_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T28267</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DQ62"/>
    <dbReference type="STRING" id="229533.A0A098DQ62"/>
    <dbReference type="EnsemblFungi" id="CEF83995">
        <property type="protein sequence ID" value="CEF83995"/>
        <property type="gene ID" value="FGRRES_08959_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G28267"/>
    <dbReference type="InParanoid" id="A0A098DQ62"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF83995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="511" mass="58280" checksum="8228BA3F07806DDB" modified="2015-01-07" version="1">MALVGLGRVGKTQIALRFAYRIKEKRPEYSIFWVPVLSAETAERAYGDMAKKLGLQKSSEDEDVKDLVCQHLSSNKAGKWLLIIDNADEEELIFGSAEKPGLEEYLPQNENGIILLTTRSGQVANDFAQADVIYIEQMDQEEAKNLFEKSLVQKHLLRDKVATGELLAYLTFLPLAITQAAAYLNQNRAPIQTYLAPLRNAEKEDMRILETEFRDNTRYKNSQNAVGTTWIVSFHQMQKSNHIAVYILSFISCIEPKAIPQSILPDMKPFELEGAVGALCSYSFLSRREGGDMLDMHSLVHTATQAWLEKLGREKQVLKDAVCHVAARFPTKNDAHYGLRREYLPHAMRLLNRNHGDEAVEVYQLFEKVGDSFDADRRFKEAIRCFEEVCRWKQGCHPKTDHSRLSSEHALANAYLNDRQVKDAIEILKHVVEVRKETLDEKDHNRLSSEHQLASAYLDDRQVKDAIEILEHVVAIEAEILVDNDPSRQLLVDLLQDCFKRLEVASDDKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DQZ5</accession>
    <accession>A0A0E0SBG1</accession>
    <name>A0A098DQZ5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T22699</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DQZ5"/>
    <dbReference type="EnsemblFungi" id="CEF83774">
        <property type="protein sequence ID" value="CEF83774"/>
        <property type="gene ID" value="FGRRES_15107"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22699"/>
    <dbReference type="InParanoid" id="A0A098DQZ5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF83774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="95" mass="10494" checksum="6D4BD0820A978266" modified="2015-01-07" version="1">MVISSLSERPCPQQQEVVKTQLFPVNHRSSWVSLQVYGRSYIPFQLSSVFLPLICLNHLSDPSTVEGSILAICKNSESSRLKTIPVGCESSSTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DSL2</accession>
    <accession>A0A0E0SD21</accession>
    <name>A0A098DSL2_GIBZE</name>
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        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG07935.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T26023</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A098DSL2"/>
    <dbReference type="EnsemblFungi" id="CEF84334">
        <property type="protein sequence ID" value="CEF84334"/>
        <property type="gene ID" value="FGRRES_13252_16931_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26023"/>
    <dbReference type="eggNOG" id="ENOG502QUFK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DSL2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022099">
        <property type="entry name" value="DUF3638"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022105">
        <property type="entry name" value="DUF3645"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046541">
        <property type="entry name" value="DUF6606"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF32">
        <property type="entry name" value="DUF6606 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
        <property type="entry name" value="DUF3638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12359">
        <property type="entry name" value="DUF3645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20255">
        <property type="entry name" value="DUF6606"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUF6606" evidence="10">
        <location>
            <begin position="23"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3638" evidence="8">
        <location>
            <begin position="2146"/>
            <end position="2279"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3645" evidence="9">
        <location>
            <begin position="2400"/>
            <end position="2432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3179"/>
            <end position="3232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="3213"/>
            <end position="3224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF84334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="3232" mass="367071" checksum="59B25A4357089C18" modified="2015-01-07" version="1">MAARLKSQGQQRQERSLSLDEALYNHLALPPHLPHRQDSNLTGIENALTDRLLASVKHLQSLPNNGHSTMWDSVRRGVETTKSIHIGGHVDRTALARELSGLGDSDFLAVYVSSQNCALYIRRSLDPVLGASVVFEAFETSARNEDVLATDNALQWDFPGCAVAIPLDTFHENGFVSHLANFLDNASRETLSEFSAHALKAGASMPEYRNASEPALISSMLMGILQQSGRRLAPTLLQKMVRDDVLWRNAEKPWRRLPYWLVLRVAMSRYLAQRLGGEIGRIEYKFLLAHLLSEFLSHIQRTNIGIDRLDFLKKKICRRLVKLDLDNERAQDPSTTDRVEYLFSRLSPGIQNAVSKANQFIEATWKQQKLAMTKTIPVLPKQATFEDTRVDLKISGQYLYKIWQGFSRPVRLGLKQQNTVSVAQAAKQHLISFAREHFKLIEKEMSYNKFCDDCGPFPRLTIETASTFIREYLPQASVYVDIPELKSTMILNIMDLWVTMDKAACSLYSILGEFHPLFRPEMIDVLILPTVAEMKRLQRVQVYLQDRIASCRGSTVSIFDDPVRGSFAHRFYDSSDMSDEMKDLHESIETWATSVRTNKEKEWKTKTEEYARLSKSVDESTCLYLVNDNDPFALPVHDDHNCRRCFLKRAMNRIQIQAYEHPLPSDPFVAKAVIFELLCPQTLATYRDVTWTIMSHLAMPAEEGIEPKCWARGYQQLHQFSNNSSMSCSLASVTKPFLTTHYATLRFPVEWDDGRSGVCRPNGLKLTYCDDRSKRWPSRRGHLSFLQHVKFQIPRSPQSTFSQIIQDTSAKSVYGASSYEIMATALRCPQGTNVHEYLAFQTVASGKSRRWLSILTELASANLNFSNEATVMLLCHLAIQCGPLDSTGSAFRLIHEVFRDPNFCMRFLEQLSFRLDSLSANWRETHLMELIITFTIRTLDFAWEANMPSIADGAISLLLRARATCVRWFKLLRAESYKFVDAETAQRFQQYALWAAILCKRTFTPLAHGPLGLDGTALEIYIQSSIMLNDNLVVKLEALPQVLQHAIIRDIRLSYRLSELVSESILHNPEAFRLSLREMWPEEEGCARTFNELKLEPEAPRWISCRTRVGEALDTVDQMVFYNFVQGTLLVDGCPMGKLPQDPNHAVVLEELFGNQSLMTYPSNRPKMQYLLCLKPFRYQVHVGYSETGELLVRAFRKPYSLQLIPREKFRNGIHSDLPGPLVDDCFHWLNLRNGEVLITRKTKPWPDSDFRSFVLSIQDSTCTRKRLYKGKQAKDYVINTYSPLFNRVTRILDSFEDRDQILVYQPEGRNLAVELRRLNLTFHTNKNRLLQSPQLQCQIDENQDAGTWYGLRSKLVCTSLTNPMHRSILVPLGHLVAQPDGCHVTVRFKATGKYGRFNINTTLGRIDCAPEPTLVFTKALLHACTSFLLPDPLTGRTGTEEAIQWLQAGISQPWTPLTPPSMAVLRRIAQLTPQRVYYPQELKVMRTDYWIDELPLRLQSSAFRPIVDRILEGSATLAIFATKDQAAIEQPELPPASEPHLHARVLLRQEAVERYLESTSSRAQPVNRHYASRDRPTVNNIMHRNVLEVTHLIRQWPKNFKTTDGLAQILSQGGTIGGFVAPLDATSLNEKLKVDILQSWGSLVRFAREAAADRYKLMYLLGPMSFHLDANMPLLRTLVASAVFADLNDLELPQWEEFEHFQPNQTPQLDYVLQLLKPYKVAPEESVAAGLGQYSSGKVLRKLQIERAKHESKVEDDCKFFANHLLSQWPCLEPTVSGLERSLLIDIGPALEAIRPEWRRLFMNRDLAEHVKEVQAILDRHTLDERYEPPPVPSSEEVYTVRIRGGELVDLRQLLAKPYHIVKAIAGENITPTECRGSTERPFLSENDFSQRFGNFAWNSNRGTGAGSVANGRRFGIAKTGADLFPTGRQVTESAARLRTIAQRLGSSKSAVRRRYADDFQQSLNAFEQLDTSQRFTGVMQTRDAAISLRSKTIEDGFYAISSALNVPSQVCSQRRIFWLQTGNLWPIVTKSTLLSCLGSVASQGSHFGSGMKKALLNMGVNITKYQREVRLHDLALKKVSGRYHEEDSNEGHSNWSPEEYPDWLLLEIESDMMIRPVQIDVALATISPESGSNSVLQMNMGQGKLGGILGRGIRHVPFSRRTPTTEKNIRAYHSIHLEMLKSAGVMICQPEHHMSFMLSGRQRLLDEQPQQAGPMIKVHEWLSRISRDILDESDYTLAVRTQLIYPSGSQTTVDGHPHRWLVAEAVLRLVDNHLYDLSNVFPHSISVIRREGGGFPFVFFLRQDVEDELVRRLTADICKGAGGILPLTEQAMPAKDRVAVKEFISSARPRPTSIKLVRNLLPDKPSLKQTIYLLRGLLVNRILMMTLKKRWNVEYGLHPQRDPIAVPFHAKGVPSDQSEWGHPDVAILFTCLAFYYDGVNLSQLRQSLEHILKSDDPSTEYNTWISSIENFPPSLKAWNSINVDDEMQLCEIWKIVRYNGVVVDYFLNNFVFPRHAKQFEVKLQSNGWDIPLSSLGINLENSKSPMGKSLSTGFSGTNDNRTMLPLNIEQQDLNSLHHTSAEVLTYLLHPRNRHCILPQDLQKSNLGRASEIDLLNCLRWMSIRILIDAGAQILEMDNITLVRQWLRIDHHALAGLYFDEDNKPWILTREGRRTPLIASPFADDLSNCLIYLDEAHTRGTDLRLPPGAKGALTLRLGQTKDHTVQAAMRLRQLGTTQSIAFFIPPEVHQSIADLQGITMHDQIDSADVIQWLLDNTCDQIEQLQPLYYSQGMDYCRRMQAALDHPKFSTIKAERKSYVQEIKQDEKQSLQSLYEPKTKSRLPGMHTSSNEILKGFILELNARRKTFQDTGKAVHASALQEVEQEREVAFEVESVRQVKKPQHYAALSFPGLNASLEAFIRTGRLPADNNYFVHVSRALARTGIGRKFKVQSEATKSKLFETVEFGRTIRPHGDLSMDNFLRPVNWILWSSVADIAVIIIPEEAEALIPLMRDLNVNVNTHLLVYSAPITRKMLQFNDMSFHSTPPLPSSWKAPDWLQIELGIYSGRLYFEWEEYLSMCAHLGIQEATTESGVEGDGESLEDEVSLEGGEVSKATAREQKQLVQTPLTFLQEWLAVRRRGQDFAHSPMGFVSQGKRLQEDHIFFKQAEHVSIECNDTMAPLPISAPTDRHENQDDGEDGVDDMGANEACTDSSDDEIEYDESEYGSTSSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DSW9</accession>
    <accession>A0A0E0SDD1</accession>
    <name>A0A098DSW9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG06953.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T23591</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A098DSW9">
        <property type="interactions" value="912"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A098DSW9"/>
    <dbReference type="EnsemblFungi" id="CEF84444">
        <property type="protein sequence ID" value="CEF84444"/>
        <property type="gene ID" value="FGRRES_16747"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23591"/>
    <dbReference type="eggNOG" id="KOG1525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DSW9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19953">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1285"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1290"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1309"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1319"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1357"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1388"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1406"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1432"/>
            <end position="1448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF84444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1477" mass="165624" checksum="572E123C6DD344BC" modified="2015-01-07" version="1">MARRRARNEKPAEVVEEEEVVEQDEEEEPEQQEQPEDRNQPSENEEEGEQRSLAFDEELSWRPAKPIPTGTLIKRLDKLSKELSELDQGATDLDSLATVAKQLGHRNLLQHKDRGVKAYTACCLVDILRLCVPDAPFSDDQLKMMFTLFIKDILPALHNPTNPYDSQHKYVLTSLTEVKSILLLHEISGADELLVRLFNNTFDGVETSGSKAATEEQVAKDVELHLTEMLMQLIDESGGVSPQVVDAIISQFLRAAPPGGSRNKGQNGNQSTLLLKAEPPAYVMAKNICNGCSDKMARYVSQYFSDVIFNASGFATKANGHRQTDDSDDEDATAGPSDADLKSLRQAHLLIRELWRAAPAVLLNVIPQVEAELSADNVHLRQIATETIGDMISGIGAAGPPPRPSLDPLAYPPLKLLDEVPAPAVENVLTKPYSPQSFAQTHHAAYRNFVGRRNDKTGIIRTAWVTAAGYILATSAGGIGLSREEDNELIKALGDKLNDSEEKVRLAAVQAIELFDFRDIVLKLGALGGVDKPGSIFASLADRSRDRKPAVRVDAMVLLGKLWAVGAGEIADEQEAVTSCLGGIPSIIINAFYVNDSDLNVLLDRVMFECLVPLKYPAIKGAKSKSTSQSQSATNQAEQDKIRSERILLMLKSLDPSAKTAFFNMQARQPQVAKGVEIFLQHCEAYNGGVIDSNEEKIKAALGRNFQWFGTFFPDPLKVRSDLQKFARINDRRWYQLIRYCINTETEYMNVRRAIHELVTKIQAKPEAAVCLDTLVPLLYRSSSLMYNRSHLATIMDYSKNEKAGFSTVAHEVLNDISQRNPDLFKAHSENLRKEIITQTPSESQPNEPGVVDILKAYSSYAKRYPDDVTYDKKFVQVLMNYALYGTPARGAKYAIKILLAKNDDKSKVTATTLLQKVMKDLKYGSPHFLTRLAAVSQLERMAPTVTIDFDEKINDLMIKQILRQVRTDEEKTEVSWVEDDGMNEELQAKCLSMRTLVNQALANQDDEDALVRVKLVFKLLKDFVVAEGEFCKVKDTPLAHKKRLRLLAGLMILKLCTVKKYDDEFDPASFNKLAELIQDTELQVRRFFMEKLQSYITQGRLRARFYTMLFLAAFEPAAELKARVETWLKSRARLFAENKTRVLEAMISRFIPLLAHHPDYSSDIDDLADFANYFIFYLNTCASEDNISLIYKYAERVKQTRDALNPEASERLYVLADIAMAVTRKWQEKRNWVFQAYPGKVGLPNGIVQTLPSSEAAHEIAQKQYMPEELDEKLDDLLRALDRKKKRKSMGEKQDPPSKRARTQIKTVIREKREPKTPKAKKVSKSKKPRPAKDSPPPSERRRSGRAHKVSIYTEREDEEDEEEMLEGVAEWDYGEDNDSESGSGGEESELSDAPEVEQAADNVNESDDEEPPAPEEDEPEQPKSNGRGSTATPKNKAAAKPAAKANVATESKRPTRATRSRRDKSAEDMDVDAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DTZ9</accession>
    <accession>A0A0E0SFX7</accession>
    <name>A0A098DTZ9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T26279</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DTZ9"/>
    <dbReference type="EnsemblFungi" id="CEF85340">
        <property type="protein sequence ID" value="CEF85340"/>
        <property type="gene ID" value="FGRRES_15559"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26279"/>
    <dbReference type="InParanoid" id="A0A098DTZ9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF85340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="58" mass="6553" checksum="9919D80901810FEB" modified="2015-01-07" version="1">MAPDLPSILLSYLCLRYEDEETTSLLTQVGRIWGAPKGKLLLRGFSGGERRALHTRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DUH8</accession>
    <accession>A0A0E0SGF8</accession>
    <name>A0A098DUH8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T23155</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DUH8"/>
    <dbReference type="EnsemblFungi" id="CEF85521">
        <property type="protein sequence ID" value="CEF85521"/>
        <property type="gene ID" value="FGRRES_15387_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23155"/>
    <dbReference type="InParanoid" id="A0A098DUH8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF85521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="58" mass="6722" checksum="B81B7B8850761F03" modified="2015-01-07" version="1">MVPMRCTHPERIRSGDMLEKYRAKTSSKVKFLGVLLSTFSVKSVTRNKRSLFPYSISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098E081</accession>
    <accession>A0A0E0SKQ6</accession>
    <name>A0A098E081_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T20683</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098E081"/>
    <dbReference type="EnsemblFungi" id="CEF87019">
        <property type="protein sequence ID" value="CEF87019"/>
        <property type="gene ID" value="FGRRES_15628"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20683"/>
    <dbReference type="InParanoid" id="A0A098E081"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF87019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="53" mass="5875" checksum="514217D502160B34" modified="2015-01-07" version="1">MDLQCMEYGGTGLTAERDVAERVSSVAMGQDRTGQDREKQRKENGNLETTVVN</sequence>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098E1J4"/>
    <dbReference type="EnsemblFungi" id="CEF87975">
        <property type="protein sequence ID" value="CEF87975"/>
        <property type="gene ID" value="FGRRES_20245"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16923"/>
    <dbReference type="InParanoid" id="A0A098E1J4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF87975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="71" mass="7878" checksum="5895C4F704613F81" modified="2015-01-07" version="1">MTRIGGLSRLGPECEHMHVGMPVPYTKEDIKDVPTILSKEGELAERCGSCFFEYTADELIYHTDAGPTTCE</sequence>
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<entry dataset="TrEMBL" created="2015-01-07" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098E4Z2</accession>
    <accession>A0A0E0SQU4</accession>
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    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 3, complete genome</fullName>
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    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T21553</name>
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    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098E4Z2"/>
    <dbReference type="EnsemblFungi" id="CEF88807">
        <property type="protein sequence ID" value="CEF88807"/>
        <property type="gene ID" value="FGRRES_17447"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21553"/>
    <dbReference type="InParanoid" id="A0A098E4Z2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd12191">
        <property type="entry name" value="gal11_coact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033789">
        <property type="entry name" value="Gal11_coact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="290"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="877"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="972"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="983"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1023"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF88807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1079" mass="123338" checksum="E4C7C48944B5139B" modified="2015-01-07" version="1">MPLQHNVSAIAKSTIKIAYDELDRTINPDDKRNFANISLQDVRDAALKIENQLAARQSLRNMRRLMPLFRGLEHYSKVVDVLCNGTPFLPWIWAPITLILRISSEFVEAFEEIIKGYASIAESLKRFEILSDALITEPDFQQTVAVFYADILKFHKYAYKFVRRSGWKLIFSASWGRFQRKFGNILDDLKHHGALIDLEANAHNISQSKKMRDDIRRWREESENRVRQEDNEHTAKQYGSIVSWLKVNDVDQLAIVDSISSEVEKYQGTCGWILQNKRIRSWADAKPNTPALWLKGSAGTGKSVLCTQLINFLKETKFVIWHFCTYLYATSTMYEQILKSLLLQILRKDADLVAYVYKTCVMERKSPTTTVLEQLLQKLLESMSSEPNQVDYVWVIIDGLDECDSDKQLRLVRLINQLTSRPVIPGSTACKVLISSRAPSDPLERLMRKQIVSLSEEKSVLNMAVRHNIFFGGHEIKESVNQLPRKLSDFYQRILTQILAPLDHRSEDRIRCILGWIAFAKRPLRKAELMSAITFSSGNYEITGLVPEYVIDTVGTLIEERRDLTVTFIHNSVKEYEANNFKKEVLLTGNRFIQTSSQPILIKQEQAFEEHGVATVACLLSGLKVFDDAYPEHDKTIRVAKGLHGIHVYATELWTEYLLNCASSNNTDTADSSTSLISLACELADELERDDVTNTTTESTTKPLENRLESLQQYPVLRKHVDRSLRSRSLQSLQSRILSDCDNEGEDNSSTTQIVYNKIETLLASYQEIVRFLLSKTFYPGLSPDELESFIVNFGAAAYTCRLTSCSYATIGFDTVEHLMEHEREHIRRFQCAVPGCQYPPLVSKAALESHMKRNHNPVIASKPVLRHLLASKRNSSNWSQVPSCDTPTDQEQVPASQSYQNKRMAVMDSMDLPQQVRTDLYNKIPLEIRKWGTLKVWLAENNIPPRVRKQLGALQKKQYKLIRHRRAKMPLDQHPKGDQEEQQQLSSQQEQQPQQSQEPGQNDAGPDSQMVQSLAFEPWGSESRQMAQSSPEPRKEGLNIMPLLNDDTPPAQPKEVNSRPGTPEDYFSFKPGPSDYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RV17</accession>
    <name>A0A0E0RV17_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG02737.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T06573</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RV17"/>
    <dbReference type="EnsemblFungi" id="CEF75092">
        <property type="protein sequence ID" value="CEF75092"/>
        <property type="gene ID" value="FGRRES_16039"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06573"/>
    <dbReference type="eggNOG" id="ENOG502SJNF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0RV17"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF75092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="434" mass="48431" checksum="0DA7F81E79C7D673" modified="2016-04-13" version="1">MAAKEGENEDNEVPIRQRKAHKKSRLGCKNCKLRSVKCDESKPSCKRCKSSGFVCSFTETSPSSFQLAHFNAGPVFSVIGRSLGPINPGLRVPVVKPVKEGMGEIVLDDFALKALERFRKRTVFSVGTKKSKRVYSEGAFMLGLKHPFLMHVFIALAYLHDEHLNPNSIASHRTPLAFHWYQATALFHRRLATASSVQDPSTLPSSERDSLWTAGALLGAASFALLDVQSVDNVWPLKESDPLDLDWLKMSDGKKVVWNLADPTRQESIFHELLAEKTSMPDGTKEIPPDVLPSIFYSVFNLDASSSASTNPYHTAASLLAQLLPHEITDNTVIQFLSFLTQLDPRFRKLLEGKDPRAMVLLAWWYTKAAVHSSWWMQRRSLVEGQAICIYLERYCTDVEGICELVKFPKRVFEICRSNGGTASEERGASVLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SPT6</accession>
    <name>A0A0E0SPT6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG11118.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T21263</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SPT6"/>
    <dbReference type="STRING" id="229533.A0A0E0SPT6"/>
    <dbReference type="EnsemblFungi" id="CEF88449">
        <property type="protein sequence ID" value="CEF88449"/>
        <property type="gene ID" value="FGRRES_17472"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21263"/>
    <dbReference type="eggNOG" id="KOG2089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0SPT6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="221"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF88449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="669" mass="75583" checksum="806AAA5C5371BA97" modified="2016-04-13" version="1">MTSRGAIPPPPSFENLKPDGVLAETQDILNSTSTLHDTLSATFTGATADFACVIRPIVDDANRAACRLRILTTLLGQLSPDRELRHAAQQAEIRAAAAQANILMRSDIASLVAAVYEKDKIVPDGNLDEQDRHLLAHMHDEYVRSGACLPSDDKREELRVALEEINALRCEAQVAFTEEEDGIWFQRSDLAGVPENALKSMTQEGSRIRVTYRNDHVTAVMRHALSSEMRRKFALAQQNRLPDNVVRLAKLVALRDHVARLLGFEHHAAFKITDKMAPSVAYVEHQLNDLHQRLNPIAIAEIKKLLRLKEMDSGAGELYSWDRAYYLHKQNQENLSADHALLAEYFEVTHTLQGMLNVFNELFGIKFMRIKTSVWHDSVVAYEAWDTPDEGGNFLGHLYLDIFERKGKYHGAQHVMIQPGFTLANNDKHYPVSALVCSFRNSAPSHPSLLQHSEVKTMFHELGHAIHNIVARTKYSIPHSRDFIEIPSIMLENWIWLPDILVRLGRHYETYKALPRDLAEGIARTRNANRASNILAQVQPALFDLAIHTPPTHKDALEMDTTAIWNLTKRDILPYSFGPTPQDLGAGQARFAHMFRKNDGGYFAYPLSMVYAADIFACAFSRDPMDPKVGRRYRYQVLEPGSSRAEIEILKDFLGREPSCKTILDELCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YHN1</accession>
    <name>A0A1C3YHN1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FGRAMPH1_01T00899</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YHN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00899"/>
    <dbReference type="eggNOG" id="ENOG502S8A9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YHN1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF84">
        <property type="entry name" value="FUNGAL SPECIFIC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="570"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SCB64038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="709" mass="80095" checksum="81D6B4657BCC17DF" modified="2016-11-02" version="1">MSMAGDLDIGNDKVEDIISGSRSALPSGVMGEGAQRKEASYRSACTECARRKQKCNREWPCNGCQKRKVADKCRFKDTNQPVIEKVAVERQRKSRVNIKSSTDSIDSELEDPASDGIDALGYTPSHLLFNLASRHETTKSKSQEFVKDPSSFPQLERALRPIPSKPYTDILIQNFLNNVNYHYYIIYPPSFLEQYQQWWASRAENQPLSIQWTCLLLTVCACASQYTDVELQRQLEGGLGHPIQRIAEQYHEAARELASAVPLGHSHFTNVQQLLHSCYWFKSEARFVECWHVLNAAIREAQELSIHKEAKAGSLSELDLEMRRRIWCILDTWDWQISTLLGKPLIIDRNDCDVGPPRLGLEGYQYSPLTHMKLQSSLIRQISGRFGHTKNITAHADVQEYQRIVEAWVDTFPPSLSVHNPDRSLDASCPWIVLHRHMIRTVTFTMLLQPIRGFLTRPFAIRSLEAELKIRSDGIDYCLELMMSLRGFFDHLYPRDAKYHFVLFCTFDISTVLCSAVLHDEQHTLPRRDDVYKVIDEAHAMLQNFRTVTKSAKASYGILTRIVQRLPRTTQTYETSGKRPKVLAPQVSEDTASPQTIPPVGIPSQQNSPPAANFSPSPINMPTPGVPSPVYSLANGPPMAGGFAPSAMYTGPPQCGDWQSQLYMQDPATFAPTQFTSQGAIFANISDEELGELANVWNYQSLDFSFINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YHZ7</accession>
    <name>A0A1C3YHZ7_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 7">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FGRAMPH1_01T01339</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YHZ7"/>
    <dbReference type="FunCoup" id="A0A1C3YHZ7">
        <property type="interactions" value="915"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YHZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01339"/>
    <dbReference type="eggNOG" id="KOG2638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YHZ7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SCB64071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="450" mass="50232" checksum="91445A0F6BE3569A" modified="2016-11-02" version="1">MDNFFALFRRYLNDKAKGNAVDWDRIAPPAQGQVVDYDDLANTESVQFLNKLAVLKLNGGLGTSMGCVGPKSVIEVRDGMSFLDLSVRQIEYLNRTYDVNVPFILMNSFNTNDDTAAIIKKYEGHNVDILTFNQSRYPRVYKDSLLPVPKDNDSPINEWYPPGHGDVFESLYNSGILDKLLERGIEIVFLSNVDNLGAVVDLRILQHMMETDSEYIMELTNKTKADVKGGTIIDYEGSVRLLEIAQVPKEHVNEFKSIKKFKYFNTNNIWLNLKAIKRVVENDELEMEIIPNGKTIPGDKKGESDISIVQLETAVGAAIRHFNNAHGVNVPRRRFLPVKTCSDLMLVKSDLYTLKHGQLQMSAARFGDAPLIKLGGDFKKVSDFQKRIPSIPKVLELDHLTITGAVNLGRGVTLKGTVIIVATEGSTIDVPPGSILENVVVQGSLRLLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YIR6</accession>
    <name>A0A1C3YIR6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FGRAMPH1_01T03995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YIR6"/>
    <dbReference type="STRING" id="229533.A0A1C3YIR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03995"/>
    <dbReference type="eggNOG" id="ENOG502S9U8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YIR6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SCB64285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="651" mass="72289" checksum="538D53341D78645A" modified="2016-11-02" version="1">MLLYTRLAPPKVPKKRSRAGCSYCKEKKKKCDEIRPACARCQERGQECVYEPVRPRQRRKRDSIAPCSPFDTNSSSGSDRATQALDAQISSEWNDDANDRSADEDSDEAPASTEAPTLNTSLVNRTASKHRVNSFDWSPTDLPLISPLDSVEFQLPPFDEPKFIVEHIENEEEDVEEIVRQESISINIPTTTYAGTYAPAFANASPSLAMIAPVPTPSPRLEFCSPMFSEFSERTNRRALVDHFCNVLSHLIVFREEGGNPFQQLVLPLCHESQPVSNAVYALASAHLEYRGVENAEKSVFFHNKAIQGLARLIQKGPGANRNELLAAIMLLVYYEVLVQKGRSNIVDGHLKGAMTIMSNNGTATDPTGVFLERAFRFYDVIAALSFGTAPLSSAPGTNYLAPFPPLDSGGATSPLNSVDTLLGMATSLWPIIHRLSNLLALKDQLDVAVANAEVSKVAVLRTEFETSATAIETALEDWHPVLPENSVLNQNPEELSPEQSTERSRLQSILSNALSYRHSAFVYLYRTIYSYPRRHPLVQRHAHISLSHCIGTVSNTGPMSALLWPLFVAACEATTLSDRDLARQTFIAINRRQGMTNIDRAWTIVQEVWRRADKTDMMQQQEEAMMMGVRSGGDLWRRVSADMGVTIVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YIT9</accession>
    <name>A0A1C3YIT9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T06507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YIT9"/>
    <dbReference type="FunCoup" id="A0A1C3YIT9">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YIT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06507"/>
    <dbReference type="eggNOG" id="KOG4472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YIT9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF2">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="312"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SCB64477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="508" mass="58877" checksum="9BED0F15F5AACB1A" modified="2016-11-02" version="1">MDLIRRATRVAPSKPPLQLPLDEKRDSKHNKAVDNRMAFFRRPLRLKGNSTISVPLGVVIFFPMLVLILIFILFVSHPSSPGRGFLIPGGAAPKMRKISEKYDKVFVEGCAQPDTSKPRANAAFVILARNKELDGVLQSIKSVERHFNRWYNYPYVFLNDGDFDENFKEAIRNHTSGEVEFGKVGPDMWGFPDWIDPKVVKEGIAKQGDAAVMYGGLESYHKMCRFYSGFFFNHPLLLKYEWYWRVEPEISYFCDITYDPFQKMIEHNKTYGFTIAVKELRETVPNIFRYASAYKRLNNITSKGLWEMFVEPPEDEEEDSPKESDTSPNDNSFWDTLTGKKKNTIDPESMEGEAYNMCHFWSNFEIAKLSWFRSKEYQDFFEMMDRSGGFWMERWGDAPIHSLAAGALLGPQDIHYFRDFGYRHTTIQHCPANAPGKQLAREPYLEKTTFPEYKRFEEDDYWEQWDDVQEGGIGCRCRCDTDVVDVEGKEGSCLAEWVDVAGGWAHPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJK4</accession>
    <name>A0A1C3YJK4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FGRAMPH1_01T17629</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the xlnR/xlr1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJK4"/>
    <dbReference type="STRING" id="229533.A0A1C3YJK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17629"/>
    <dbReference type="eggNOG" id="ENOG502QUI0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJK4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000004">
        <property type="entry name" value="Xylanolytic transcriptional activator XlnR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="132"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="539"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="732"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="742"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SCB64734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="934" mass="102552" checksum="65A69C336D5FC9C6" modified="2016-11-02" version="1">MLSNPLQRFSPYQNAASSNISPDGNVQQGTMQNGGLDSLQNHQYPIQPLSQAVPLSNGHFERAAAQVKNRQHPYGVHPRSSSTSGPIRRRISRACDQCNQLRTKCDGQHPCAHCIEFGLGCEYIRERKKRGKASRKELAQQAAAQAAAGGTGQNMDDSLSENGQTSSKGLESSNMGLEQQSNERHPSTSSKSSRDPGDDVMRHTQGLEGLDHLGNISEQPHLGRSSLDGEHMENNGGLDLNGFNSMPHAYDSQGLDGPVLNGQSYAPNGRGNMPGYAEFPYTMQAQSPPNFNNNSAFRMGNSPLGYAMGKGTSPGWGISMTSPPGQYQTQAPPPNFNNSKLRYPVLEPIIPYLNNIIPIPLACDLVDLYFASSSSAQMHPMSPYVLGFVLRKRYFLDQTRPRPCQPALLASMLWVAAQTSDAPFLASTPSARAKTCQKLLELTVYLLRPLIHTAPSDAPSPVADGVALGGLGVAMPGSISMEATSGESGPFGAAGSLDDVITYIHLAVVVSASEYKGASMRWWTAAWGLARELKLGRELPPGPSPAAQEAMDTDGTEDAEGGISGNGYVGEEEREERRRIWWLLYIVDRHLALCYNRPLFLLDIECQGLLQPMDDAYWQSGEFLNNSNSTTDPNLLGTSPEGYRTDHPHPHGPQYECRGHSIFGYFLPLMTILGEIVDLHHAKNHPRFGTSFRQSHEWNAQTAEITRHLEIYEQSLQSFERKNLPRQVEDRADVANEGNGVPETNTPSVHSVHTNSSNRLTESNIQTRIVIAYGTHVMHVLHILLSGKWDPINLLDDEDLWISSQGFITSTSHAVAAAEAINLILEFDPGLEFMPFFFGIYLLQGSFLLLLIADKLQSEASPSVAKACETIVRAHEACVVTLSTEYQRKFSKVMRSALAQVRGRVPEDLGEQQQRRRELLAVYRWTKDGTGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJW2</accession>
    <name>A0A1C3YJW2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T17607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJW2"/>
    <dbReference type="STRING" id="229533.A0A1C3YJW2"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17607"/>
    <dbReference type="eggNOG" id="ENOG502SABA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJW2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="631"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="559"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="831"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1071"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="566"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="636"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="679"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="755"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="890"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="902"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="940"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="991"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1034"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1079"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1135"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1147"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1164"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1188"/>
            <end position="1214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SCB64731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1214" mass="131785" checksum="5FD75D34B12BDBBF" modified="2016-11-02" version="1">MDVTKDPAAFMHTPPSASASGRRDSFQWAARQDSGNNQDILPGTGVRAQSPTSLHIRSVPFSSSASAQLFARPQTPDAGVGCRNRQNLPSPASTDLSPQKEPWADDYISRLLRRVRHHPNGGQRANTSPVMADFLASLGFGGAQTTAVSNNSQCDSVEQLQNQLRGILDAKVTPTRAEHVAITTELRATVRFQLTASELENGNHDNPNNLDPALGGAQSTEVNGDQDAGQPSRVVFANDTIMNQPQDDPALQRSVAKHIISTISSADGSTWTVREVSRGAQGWTFTYLCKDSFQHWSRQTAKNPLKTIVGEFTRPAFDCRGSIVIAFNRSSRSISVKYDHTPLHKTVAELAAHFKPPPRQLGPGAQKLQEQQQKAKEKTLKKPRGEKKDKKERKKRDSVKAQDENGNPRKRKKKTNGASQPETTDGSMTPLDYPGASAVGGQTDPSYMNGGQAPDNTGHQGFNDYPQGLMGDASGATNGTGSQQAGGQPGSVTFPVNVSAAEAARRREAATAMLNNAGVDPTTLSPEQFGIFSNQAPELQRESLNMLVNYGAERLRIVHPSNREGSAQASASTAQSSQSSTGPRTTKELVPQSGAHDSPNTDFEAQAASQTADDTSSPKRKVRKMGKSRTACFPCKARETKCPRERPTCTECSNHGTACEYAPQKPRNRGKKTKKSEEIDIDDDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEQQEDAEDAEDVEAEGDEEEDDDDEQAASQDYSHPQMNIGNMVTNTDATTQDSHATQSNYYQSTSSLAMPQANPYPNNPQPLTTAASQRNNYSHALPEVIQPVHHVPPPIPAPAGTIAPSETRRWTAFGSGGLNGASDSSKARRGLPSEPPRPTTQSPSTTNVQLSSWGQSSNTTMPAVPATTMATVSPQMSYDSRSSHRSRQKNQSLSNDSAQQAAAMASTAMPQAQVQVHAQAQARQSPVAAAAMMAQARKSPYQQVAVPRTTSRTSQRNQSRTPVTEQARGYQPPPPVDMGQQQSARPGAHYDTSSSHMPSGSGYNDYGRYCGANTAANHQAAMSAASATPSTMGTSCQSKPATANQWSGSSSRNDRSYGSNSSYQTPNIYTKTPAAKSVSASGQNFKMRPGTQQQHQQQPQHAHGSSNSYSQQQQATYPAYSGSTHQNQQGQTSNQQQQQQPPSWYFQNSHNPSMHHGSQSSGYNYESWSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YK13</accession>
    <name>A0A1C3YK13_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FGRAMPH1_01T17057</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YK13"/>
    <dbReference type="FunCoup" id="A0A1C3YK13">
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    <dbReference type="eggNOG" id="KOG0465">
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        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="EFG_III/V"/>
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        <property type="entry name" value="G_TR_CS"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
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    </dbReference>
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        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EFG_III"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ELONGATNFCT"/>
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        <property type="entry name" value="EFG_C"/>
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        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <property type="entry name" value="G_TR_2"/>
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    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="47"/>
            <end position="342"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SCB64695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="822" mass="90999" checksum="AB0DDAFB5C070B73" modified="2016-11-02" version="1">MIILSLLRSGPAIKGSGRCLARQWRNKELVNLSRRAMHQAHHDTQLQNIRNIGIIAHVDAGKTTTTERMLYYSGVTQRVGDVDSGNTVTDFLDLERERGITIQSAAITFNWPLHQSLAPGEHAKTINLIDTPGHQDFRFEVDRCLPILDGAVCIIDSVKGVEAHTERVWGSAHEFRVPRIVYCNKLDREGASFKKAVLEIGTRLKGWPLVCQIPWWEKEDFVGVVDIVNRVGYRWKSEREKTVYNTAQLKEKLSSSNKDLLPEIETARQALVEGLADFDDAIMDEFLAENENIDAAIIKQAIRRVIREGDGRVIPVFAGSSFRHIGVEPLMDAITDYLPSPDERPSAEVRVGSTKQRLIEVLDNSPKSARGQVSSIASVFKVFNHPKEGVISFVRVYHGTLTRNAASFNTNILANEKPMGILQISANQTQDIQTLGVGQIGALRGLKKARTGDTLITMNGNKPIPESFRHVKIRPPEIPPPVAFLQVDPYGNVAAQQLQIALENTTREDPSLRYSRDPKTEQFTIQGMGKLHLDVSLYNMKQKYKIDADFGPIEVDYKECVTEPTQPQHVIFDRPVASKPGKVSCTVTLEPLEEHHRESLLESSVERDGNIYHVVIPLAEGAATLNFDPKEARAQLLNGAIAGLARGPRRAAPVHGCNVTITLDTEPGACETPTGGHFSSASRSAVQASLRDAFEKEQIGVLEPIMLVNITCPEVVAGAVQHDVTAGASGQVLEVNDRSAESTGEDHIDVSKIYTPPDPYDSITSLRGKKSTARVIEIIAKVPYKEMLDYDNHLRSKTAGRHSMTMFFDSFAKVVGHREKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YK67</accession>
    <name>A0A1C3YK67_GIBZE</name>
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        <submittedName>
            <fullName evidence="4">Chromosome 3, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T18311</name>
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    <organism evidence="4 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YK67"/>
    <dbReference type="STRING" id="229533.A0A1C3YK67"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18311"/>
    <dbReference type="eggNOG" id="ENOG502SA4F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YK67"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF4">
        <property type="entry name" value="PROTEIN DIAPHANOUS HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="432"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="432"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SCB64787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="599" mass="65221" checksum="32099884A0D94821" modified="2016-11-02" version="1">MSGYGYGPPPPPPPASSGGPASYGPQAPSYPQNGQGRGGHHARGRGGHYSGGRGDYHGSPQSRYEYGSQPQPYPSHHNPPPYGASHPPAYPPQPQWGPEHGHPPHGHAPGPMPSGNYHSNYATQPYPPSQYPQQPPYGAPQAYPYQGPPPPNQPQWNAGGQPPGGHYGGGRSRGGYNDRNGPKPPLVGHVRPGYEHEAMPPTNGYGQPYPHDPRAVHYPPPQYPAYPGPPPPLAHQQDGYYGHTTRRGRGGFRDGNARGRGGHHGNDKSRHQKHGHNDSNHKSETPTLGKKKKRKTNTLGLTPGMDSESEDDEGEEKVLTDLIGQETLNVKDVAAFLADRKKHFPTKARVEAKKTAELAQTGEDKASSLEKQADKLRRQLRKVESSIKRKREQGDEGDEMRDPSEESSDDEPEVMSTRSHVAPPPPPPAKKADVSKHCKYYSTGGTCGKKGKCRFVHDPEAREAAMKDREANNGRLTIQQRLILNDKEQEDLTVLQSIQYLRKKGLMQPEDPEVKKEAKSAKPDLPAHPPPPSLLPAASASLPPPPVKREPNLPRHNPPPSTVPGANSNHTQGVKPYQGWTMRPYGSTNGKSTKSDDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKD5</accession>
    <name>A0A1C3YKD5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T19847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKD5"/>
    <dbReference type="STRING" id="229533.A0A1C3YKD5"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19847"/>
    <dbReference type="eggNOG" id="ENOG502QX1K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YKD5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034586">
        <property type="entry name" value="Bfa1/Byr4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140:SF1">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="638"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1013" mass="112590" checksum="63A8478A97D91D92" modified="2016-11-02" version="1">MEPLRLKPRQPVEADIENWDDDDFVVETDDLSFRSPSTSTNIPSRPTSSRRRDSGSSHFSFRSEAEGEEETHVHIPGDDEKSTLDAIAAAQNAGIPLPTNVPSSALMGGTIKRLGGRKIRKIVHDDWENDLEIPDSSQGLKIKRPEQPKSPDTSRHVSFGSTSTHTSPINWGNSPPTSPFDQDTRRESGHSIQAFQSMQSIQSATSNLSAAINLDRFKDGDDDDDFFDGGDTIRASKTHQLPKPVSFITPPTPQRDVKPAKAASTDDDFETDLELPSDGKLKLSMRKEIPKTPANQSDDLDWGEGSLGTRWGGTRRDTRSARNSAASALSPSISSSITAESEDETFDGLVLPPGPVNWTERLQQRRKSKSPNRISEEPIVPPKKVPAEADKPDFLDGLDIGEGDVFDSSKLTLHKNVKVKETRPASPARPKTALSLTFTNKPVNSTRIPRLNHHERTHSTSLEPVSESGGPIPQRTRRSHSRMGHSAQSSIASMPTPTTTSPSRGMPPPPPRRREVGTRTSTNSLRNEPTTTSAQLLKQKRSMPAIRASNTPARQSAYRHDRPPPRSESNRPSSGIRPKTPTERQRQGSMDSPATVRKTHLPFLPAGASQSQSQHVATKRSGFRRHDSDTSIGSIDLRPSSRTISRSTMRSPSPNHRHRATADTWERLSKPKNKKNFGDGHELDGFDDLPTSRETETRYLKQPTSSGPKVAMRNKLYQNVLPDRNLVNSPSHPAPRPSFTPHFARDTAASRIARETALAQRVPSNGPLTPLNSQRTTHLSSRSNLTPTIPHHSNIRSRKHKRPQQTKPHLISNLNSGKESKMVNGMFYNANTYRWEGNENALNVFEPPVQTPTQAVASTTTREKDSATPRPALITNISATKGVQVVGGMVFDPQNMCWLKLDNPAQPSSETSDTMDGFDALDDDDEDVFKDIPDLEDNTVDDEGVQGRTSDIKDEWLVGEEFDVGPEFIRRQREEEDRWRRKCEKWIGRGSRDREAWRWTIRELVSQFADLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKU0</accession>
    <name>A0A1C3YKU0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T23707</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KNR4/SMI1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="SCB65161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="FunCoup" id="A0A1C3YKU0">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YKU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23707"/>
    <dbReference type="eggNOG" id="ENOG502QTAZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YKU0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0097708">
        <property type="term" value="C:intracellular vesicle"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:mating projection tip"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009203">
        <property type="entry name" value="Knr4/Smi1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051873">
        <property type="entry name" value="KNR4/SMI1_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432:SF1">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017023">
        <property type="entry name" value="KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Knr4/Smi1-like" evidence="3">
        <location>
            <begin position="151"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SCB65161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="517" mass="56614" checksum="41DABE8F88C57672" modified="2016-11-02" version="1">METSLGATIRSFWHTMTSYDRHSSFDSPYRTGRHVPLQDGRGGIMTGVATASDSRNDVSSPYTDETGRGSPRLDANTFAPTGAPYSPGLRSMSARNASQGDGFEVQSPGDVPMQNFNDGLPPAPPVAHSWRRIDSWADDNYPELFDQLCEGATNNDLNDLEHQLDCSLPQDVRDSLMIHDGQERGGLPTGIIFSHMLLDCEEIVQEWDNWRTVNQQLLETSVAKPSTPSKAFGGSNEASSSKQGGGASNSPGPWRQDLMSRQDCVPANAVQKAYAHSSWIPLVRDWGGNNLAVDLAPGPGGQWGQIILFGRDYDTKYVVARSWSAFLAVVADDLNSGKWYVDEDTSELKLREFKETRVEPPYFSILRWRMDQKYGRRAPSKRRSMGPKPSSPLGSRSSSPYGSGGESEGRGRSMQRLSGSSPLASPRPGAGPGYGKATPLSRVTEETAIPELADAYIQPEKLVEVETPRHSQDSKTPTVTSIPRVESDLLKVEEEPSPKANGKKPELVDEPMKTIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKY4</accession>
    <name>A0A1C3YKY4_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T22501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKY4"/>
    <dbReference type="FunCoup" id="A0A1C3YKY4">
        <property type="interactions" value="199"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YKY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22501"/>
    <dbReference type="eggNOG" id="KOG1223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YKY4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005950">
        <property type="term" value="C:anthranilate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="2">
        <location>
            <begin position="45"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="1">
        <location>
            <begin position="242"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="1">
        <location>
            <begin position="336"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="1">
        <location>
            <begin position="488"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB65067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="576" mass="64174" checksum="06387CFEE7CE8692" modified="2016-11-02" version="1">MDHTNLLRQLDIRPTADEARNAYNQEWTPSTQPTLLPVCASAPADLLTPSAIYLKLSSGATAEYSFLLESATGSTETVGRYSFIGANPRKVLATGDGYQHSGDPLKTLEAELSHDRVLDIPSLRLPALSGGAVGYVSYDCIKYFEPKTERPLKDNLKIPEALFMLFDTIVALDHFRSTLTIVTHMKLPKNPSDDIQPAYDEACETLKKTLDIIFQPETPLPKQTLSAQSESDQQFSSNVGRKGYETFVTELKKYIVKGDIIQAVPSQRFRRSTQLHPFNIYRTLRTLNPSPYVFFLSCADFHIVGASPECLMKTDGYAPLPSDSRFGYSAAEARSRPRIVNHAIAGTIHRGKNAAEDDRLAAELLASKKDRAEHVMLVDLARNDVNRVCHPTTVKVDRLMRIDRFSHVQHITSEVSGVLRPECTRWDALRSIFPAGTVSGAPKIRAMELIYDLEQEKRGIYAGAAGWFGYDIVRVDDSSEQQDKIFVDEGPMDTCIAIRTMLVKDGVAYMQAGGGIVYDSDPTDEWMETMNKLSANLRCVELSERYFGDGVSTKTVEEIIAIERKKGEEEIKAAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLB4</accession>
    <name>A0A1C3YLB4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FGRAMPH1_01T25859</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YLB4"/>
    <dbReference type="STRING" id="229533.A0A1C3YLB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25859"/>
    <dbReference type="InParanoid" id="A0A1C3YLB4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SCB65327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="218" mass="24857" checksum="AF18637BA813FD51" modified="2016-11-02" version="1">MAHATMLARRQLASSSLSTRATSIVGLVQQRGYATPHGPPPANFRTSKPVRWTWDNESTLDRMGKFFLMTEMARGMYVLLEQYFRPPYTIYYPFEKGPISPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEERADGSRRTTKYDIDMTKCIYCGFCQESCPVDAIVESPNAEYATETREELLYNKEKLLSNGDKWEPELAAAIRADSPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMD8</accession>
    <name>A0A1C3YMD8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FGRAMPH1_01T11085</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A1C3YMD8"/>
    <dbReference type="STRING" id="229533.A0A1C3YMD8"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11085"/>
    <dbReference type="eggNOG" id="ENOG502QU2F">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A1C3YMD8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:spermidine transmembrane transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050277">
        <property type="entry name" value="Sodium:Solute_Symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086:SF10">
        <property type="entry name" value="AGR155CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086">
        <property type="entry name" value="SODIUM/PROLINE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="68"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="178"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="244"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="291"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="331"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="399"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="451"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="510"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SCB65681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="522" mass="56477" checksum="BB503A09CCBBC05B" modified="2016-11-02" version="1">MGFPSFAASNAVIYVTYGAFLIMGTGIAWKMRNQSKADFLSGNGTQTAFPLALNFIASALGSGILFSYPELATISGVQGMMVYALASALPMLIFGYLGPIIRRRCPEGFVLTEWTRQRYGIITMLYLSFMSMVTLFLYMVSELSAIGQVVQALTGLDPLPVMIVQCAITTIYTSLGGFRISFITDVVQGTMVVGLVIIAAITIGAKTEIQRPLIDESGLTKPNLLGWQLLYILPVAVLTNDFFLSSFWLRTFASKTDKDLRIGTTIATIVILCVLTLVGSTGLIAVWSGALPLADKAGSGSVAFFVLLETLPSWVVGIVLVMVVTMSTAAFDSLQSAMVSSGSNDLFRNKLNIWYIRAIVVLIIIPVIAIALKAPSVLQIWLITDLISAATIPVLVIGLVEKFYWWRGFEVVVGGLGGILTVFIFGCVYYGNAKEAGELLLVQKGLYGNDWSAFGAFVAAPVGSLLWGCGAMVVRITFQYVHAKVRGHRFDALDRPLDLRSVSREDDSPSENLVSQTAGKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMZ4</accession>
    <name>A0A1C3YMZ4_GIBZE</name>
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        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T13889</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YMZ4"/>
    <dbReference type="STRING" id="229533.A0A1C3YMZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13889"/>
    <dbReference type="eggNOG" id="ENOG502SIHU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YMZ4"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SCB65872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="583" mass="65052" checksum="860D6E77645A6298" modified="2016-11-02" version="1">MATSYRPIQPALSKGGTFLKGLQARVGPKRTGMIKSACWECRKRKAKCNGLKPTCANCEKSDAECIYDSDIRDARVRNLQRANQRLEAELEAAKTLLKQVASGSDQIRSIVLELLQNAKEPLEILEMLNNNGGIDSTMENSQVPHVMTAPYLPIEGVVPDADPCSTSDSKLAERGYSLTATTALYQSQLDIPAVPTKLVKDGPASLQPPQVLQSQPQAIIAPSHNTIAGSSYPILLANNPREISHQSGTQSLFFEPLFEHADFLLTTAYDIPGRSPHSAQHIITRHIDPQSQLVHDGPTLSVPTDISHVDNYALPQSDVQANTQEAMSSSLGVQPNFRNHFNNLSLSSSIRANGYPRKIQDAQIRNIFVPDWAATSLNTIPDPGHLEDAFADIYKLATSLLESGEPVHRIVGHHPNLAALYDQQEFDRSCLLSQWAARMVHSVKRQGYDFTCFASMNVFWYMMRWMVYPSPESYAAMPEWIRPMSSQLFTPHISMADFVLWPGFRELVVQLPQLQERMAWLADMSLYINCEWPYPLEQALHRDPVSGDTDLVDLAKQHVWTLGCWSVGPSFRKFVPNADSYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1RA83</accession>
    <name>I1RA83_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG00410.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T01073</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316076.1">
        <property type="nucleotide sequence ID" value="XM_011317774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RA83"/>
    <dbReference type="STRING" id="229533.I1RA83"/>
    <dbReference type="EnsemblFungi" id="CEF72338">
        <property type="protein sequence ID" value="CEF72338"/>
        <property type="gene ID" value="FGRRES_00410"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00410"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01073"/>
    <dbReference type="eggNOG" id="ENOG502S9W4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046290_1_0_1"/>
    <dbReference type="InParanoid" id="I1RA83"/>
    <dbReference type="OrthoDB" id="5400063at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF72338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="342" mass="36548" checksum="9475E7430C00521E" modified="2012-06-13" version="1">MEPVPETERMEEFRPAPTPAPVSASTSVSASPAASPVVPSLRLQNPNAISNLSIDLPRKPPNLRRSTDPSPTSPASPSWSSSPFIPYRPRTTSPLSGAHTRSRSTTSLAPPMSRTQSMPGVNGSGHILFLSQHRPGSPSASPSRVRIPRKPADESFPPISPVRTSVIEPEQRHERRSTSPIMGISTSTPARLRRPSSPLRSFTSSSTGSLGTFPSTPSSSISSSSSSSYRSYDALSGSYGTTYSSVPSTPTSTRSRSPSISSLETIPDTPDAEEAALEAERIAQLKADADAAEGNDSSDLKGKDGQMRGRTMGFGSRDKRKRWSVCGAERRGDIDLETIWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1RBA3</accession>
    <accession>A0A098D1K0</accession>
    <name>I1RBA3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG00814.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T02035</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316527.1">
        <property type="nucleotide sequence ID" value="XM_011318225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RBA3"/>
    <dbReference type="EnsemblFungi" id="CEF72818">
        <property type="protein sequence ID" value="CEF72818"/>
        <property type="gene ID" value="FGRRES_00814"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00814"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02035"/>
    <dbReference type="eggNOG" id="ENOG502S92K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064039_0_0_1"/>
    <dbReference type="InParanoid" id="I1RBA3"/>
    <dbReference type="OrthoDB" id="2135488at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052358">
        <property type="entry name" value="Aro_Compnd_Degr_Hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563:SF2">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="16"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF72818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="293" mass="32993" checksum="8EE231A15B2F768B" modified="2012-06-13" version="1">MASSDLAQLIPPDSWDSHMHIVDVENYALDPSAIYRPSSHTLEQALNFETSVGLRNIVLVQPSIYGLNNSCLLDGLRDLGSERGRGVVAIDPKAFDADELRKWHELGVRGVRLNLQSVGAELDAAELEQQLTLYADAVRPLGWVVQVYVPMKMIELLEPIIPKLNIKFCIDHLGQPPLKDQQGVEMYDLPGFSSLTRLLKDGLTYVKLSAPYRIAAQSDYSDLDPLAKEVIRIAGNSHVVFATDWPHTRFEGLDIRPWMQRVVGWCGDDEHLKERLFRGNAEDLWDVKRSPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1RBA4</accession>
    <name>I1RBA4_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG00815.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T02037</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316528.1">
        <property type="nucleotide sequence ID" value="XM_011318226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RBA4"/>
    <dbReference type="FunCoup" id="I1RBA4">
        <property type="interactions" value="579"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RBA4"/>
    <dbReference type="EnsemblFungi" id="CEF72819">
        <property type="protein sequence ID" value="CEF72819"/>
        <property type="gene ID" value="FGRRES_00815"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00815"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02037"/>
    <dbReference type="eggNOG" id="KOG1635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_10_2_1"/>
    <dbReference type="InParanoid" id="I1RBA4"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1060.10:FF:000006">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="7">
        <location>
            <begin position="41"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF72819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="206" mass="23159" checksum="9CB4C08A4A4A1431" modified="2012-06-13" version="1">MAFNLPPFLARLARPFTQSSRLSIAPDQSAASVIPEGAQRCTVAAGCFWGTEHLYRRHFADKGLIDAKVGYIGGDLENPSYRAVCGGKTGHAEAAQIIFDPTKVTYAQLLEFFYKTHDPTTLNQQGPDTGPQYRSAIYFHNPEQEKIAREVTEKANKQWWKGGIVTEIAPAGKWWTAEEYHQLYLHNNPSGYECPSHFMRPFPPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1REZ0</accession>
    <name>I1REZ0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG02249.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T05421</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318147.1">
        <property type="nucleotide sequence ID" value="XM_011319845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1REZ0"/>
    <dbReference type="STRING" id="229533.I1REZ0"/>
    <dbReference type="EnsemblFungi" id="CEF74515">
        <property type="protein sequence ID" value="CEF74515"/>
        <property type="gene ID" value="FGRRES_02249"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02249"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05421"/>
    <dbReference type="eggNOG" id="ENOG502SR6P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101050_0_0_1"/>
    <dbReference type="InParanoid" id="I1REZ0"/>
    <dbReference type="OrthoDB" id="5362269at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124096" evidence="2">
        <location>
            <begin position="20"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF74515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="201" mass="20642" checksum="162826E668EA1E1E" modified="2012-06-13" version="1">MKTTTFAVALLGLFPAIFAQETLAPSPTESVGCEPHGDHWHCDGARSTLATEAKVTTDAEHDDEHDHDHDHDTTGTGSLAPSPTESTGCEPHGDHWHCDAAKTGSSEAKATDDHDHDHEDEDHSHSAGATKSLSPSPTESTGCEPHGDHWHCDGAATAAATGSASNSASATESDSAAVTDNAAVIQIIPFAGIVAAAVLAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-05-25" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>I1RF49</accession>
    <accession>A0A098D813</accession>
    <name>NRPS4_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nonribosomal peptide synthetase 4</fullName>
            <shortName evidence="5">NRPS 4</shortName>
            <ecNumber evidence="4">6.3.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Fusahexin biosynthesis cluster protein NPRS4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NRPS4</name>
        <name type="ORF">FG02315</name>
        <name type="ORF">FGRAMPH1_01T05575</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2012" name="Fungal Biol." volume="116" first="855" last="862">
            <title>Overexpression of NRPS4 leads to increased surface hydrophobicity in Fusarium graminearum.</title>
            <authorList>
                <person name="Hansen F.T."/>
                <person name="Droce A."/>
                <person name="Soerensen J.L."/>
                <person name="Fojan P."/>
                <person name="Giese H."/>
                <person name="Sondergaard T.E."/>
            </authorList>
            <dbReference type="PubMed" id="22862913"/>
            <dbReference type="DOI" id="10.1016/j.funbio.2012.04.014"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2021" name="J. Nat. Prod." volume="84" first="2070" last="2080">
            <title>Cyclic, hydrophobic hexapeptide fusahexin is the product of a nonribosomal peptide synthetase in Fusarium graminearum.</title>
            <authorList>
                <person name="Westphal K.R."/>
                <person name="Bachleitner S."/>
                <person name="Severinsen M.M."/>
                <person name="Brundtoe M.L."/>
                <person name="Hansen F.T."/>
                <person name="Soerensen T."/>
                <person name="Wollenberg R.D."/>
                <person name="Lysoee E."/>
                <person name="Studt L."/>
                <person name="Soerensen J.L."/>
                <person name="Sondergaard T.E."/>
                <person name="Wimmer R."/>
            </authorList>
            <dbReference type="PubMed" id="34292732"/>
            <dbReference type="DOI" id="10.1021/acs.jnatprod.0c00947"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4">Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of the fusahexin, a cyclic hydrophobic hexapeptide with the amino acid sequence cyclo-(D-Ala-L-Leu-D-allo-Thr-L-Pro-D-Leu-L-Leu) that plays an important role in cell surface hydrophobicity (PubMed:22862913, PubMed:34292732). Fusahexin might also play a role in virulence, sensitivity to osmotic stress and oxidative stress (PubMed:34292732). NRPS4 is the only enzyme within the cluster and its 5 catalytic modules are sufficient to produce fusahexin (PubMed:34292732). The modules 1 to 4 incorporate respectively D-alanine, L-leucine, D-allo-threonine, and L-proline, which is supported by the presence of epimerase domains in modules 1 and 3, which incorporate D-amino acids (PubMed:34292732). The terminal module is responsible for incorporation of the two adjacent leucine units, where the epimerase domain is only used to convert the first unit to D-leucine (PubMed:34292732). The terminal condensation domain (Ct) is involved in cyclization with D-alanine and thereby releasing of fusahexin (PubMed:34292732).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-allo-threonine + D-leucine + D-alanine + L-proline + 2 L-leucine + A = fusahexin + AH2 + 6 H2O</text>
            <dbReference type="Rhea" id="RHEA:72047"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:58645"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:143079"/>
            <dbReference type="ChEBI" id="CHEBI:191392"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:72048"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="domain">
        <text evidence="8 9">NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, methyltransferase domains (responsible for amino acid methylation) are present within the NRP synthetase. NRPS4 has the following architecture: A-T-E-C-A-T-C-A-T-E-C-A-T-C-A-T-E-C-T-Ct.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3 4">Does not affect conidiation but results in reduction of cell surface hydrophobicity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.-" evidence="4"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318224.1">
        <property type="nucleotide sequence ID" value="XM_011319922.1"/>
    </dbReference>
    <dbReference type="SMR" id="I1RF49"/>
    <dbReference type="STRING" id="229533.I1RF49"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T05575">
        <property type="protein sequence ID" value="FGRAMPH1_01T05575-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G05575"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02315"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05575"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_60_0_1"/>
    <dbReference type="InParanoid" id="I1RF49"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
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        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
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        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
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    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
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    </feature>
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            <begin position="244"/>
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    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="7125"/>
        </location>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="34292732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="22862913"/>
        </source>
    </evidence>
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            <dbReference type="PubMed" id="34292732"/>
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    <evidence type="ECO:0000305" key="8">
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            <dbReference type="PubMed" id="22862913"/>
        </source>
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            <dbReference type="PubMed" id="34292732"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="CEF74592.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="7639" mass="843997" checksum="F11CB81AFFCF07A1" modified="2012-06-13" version="1">[encoded data, 7639 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1RGN3</accession>
    <accession>A0A098DGL2</accession>
    <name>I1RGN3_GIBZE</name>
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        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG02905.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T11583</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322897.1">
        <property type="nucleotide sequence ID" value="XM_011324595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RGN3"/>
    <dbReference type="EnsemblFungi" id="CEF77595">
        <property type="protein sequence ID" value="CEF77595"/>
        <property type="gene ID" value="FGRRES_02905"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02905"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11583"/>
    <dbReference type="eggNOG" id="ENOG502RSI0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010063_2_2_1"/>
    <dbReference type="InParanoid" id="I1RGN3"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124204" evidence="3">
        <location>
            <begin position="26"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="628"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF77595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="661" mass="74336" checksum="34B483BADA3357D8" modified="2012-06-13" version="1">MTFSLTTKVLIVSLVCLLFAGRVSAFGAGEVAGTSSFNGYVWRHGDIAEALRYLPASFVTHYRFTALERRQIYFGNWLRDFSQIIDTTGLETVPEPVLRAIVSILGFMEFGFATDEFDVTRERLGCYTHVEHIDNPKGYPDNAKDVDERLRGPVDPRELEFDPKTGMKNYIANSGHGWDTSADYVTRQLRECIRLGRDKDPKSKKEAFIHLGAALHTLEDFSAHSNFTELCLQDLGESDVFAFVGDACRVQTPGWRGRMVPPIVTGTFGMLDIFHSLLGEADDMAVLQCKGSLENLENEMNIGEIAFQHLYDILRAAIEALSKLASNTTIHDPILQQLESVGVLFEKAEESKKASTTAESTLDANNLWQTIEPIFYLHDRIKKWIQERTETHDDEPLSEDSSSQLGKYTDQLVFKYLSLMIESSIMQLRNALKAAKERVDAEAAKSTSAEVYLDGEGSDPSHSDISKDHFSNVLNQPAGLVSTVTTNWTTQQVVKCWDDPFRDEEESIRQILTIMHHPAFPGRHKTPIQKYMFTAVEEWWNHNTASEKETIRGMLTKESVRNRQHENHTLTLKDLEGKRKGVAEFPGSRPKIKQKPAKPSPLSWAVSTAKTDAKWMLGALKRGVRDPIGAVCFVGGGVYMLFVQIFLIITGVFGLWKAKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>I1RHJ0</accession>
    <name>I1RHJ0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG03246.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T12415</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322505.1">
        <property type="nucleotide sequence ID" value="XM_011324203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RHJ0"/>
    <dbReference type="STRING" id="229533.I1RHJ0"/>
    <dbReference type="EnsemblFungi" id="CEF78010">
        <property type="protein sequence ID" value="CEF78010"/>
        <property type="gene ID" value="FGRRES_03246"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03246"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12415"/>
    <dbReference type="eggNOG" id="ENOG502SJK8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011915_0_0_1"/>
    <dbReference type="InParanoid" id="I1RHJ0"/>
    <dbReference type="OrthoDB" id="5376052at2759"/>
    <dbReference type="PHI-base" id="PHI:1907"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF28">
        <property type="entry name" value="C6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="730"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF78010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="758" mass="84159" checksum="69ADD55643B9F222" modified="2012-06-13" version="1">MTMTSISGPSMAEEEANSTLSNDDGSSGDDSRLAGAGPSKKRRREKHQKISCEMCKTRKVKCDRAEPACSWCARHNKACVYLERQRPGAGRNGFSIELEAKVNRIDALLQALGRRVEEHIVQDHSSVVSPGVSSTNVNGYNASQLDSRLTPATLPRHSSFSQAKSPAITSPWQANNSNQNTSHPSVQNQQQGASAPTPTHTNISIPTSIGRNPSVQSYTIDLPPHDIIYSLVDLYFKHCGTWCPILERKTIFATFFGSTSMEEPDRILLYAIVATTLRFLKDPRLSPEMSAYYHSVAKHTVQLYAMEHTTVPALRALVIITLDELGTSNGPRGWNLLSLLAQNARQLGLCEESSVFLSAEASEVTHTASSHRVAAGKPESWIEDEGRRRLYWMIYLLDRYATIATPTFDFILNDTKIYRFLPCSYDLFSKNVPVETRSLSPCNNKQSPIMTYLVNKPENLGSFAYHCEILVILSRIHEFLKTPVDVTSPSDMAEWRNTYRNLDRTLDGWLQSLPSEYSKISALCHSDPASRVANWFMLHSAYVTAAVRLHSSAAYPTVRSHIFVPSHYAMQRCLSAVQSLGDITRDVLEADGLNLLGPSFAFSLWVAARLLLVHAATVGCAVDSQIDFFIETLRDVGQHWEVANNYSKILQRVVQRARQGDMGFSSMRRSAYDLVTLTSTARHSGLEATSVQATSLSELDNIDVFEFFNYPRTSSCSNAQSQLQLQPIRTPALGPESSRGNGVPDPEADWLAFGSPYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1RI88</accession>
    <accession>A0A098DH85</accession>
    <name>I1RI88_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG03517.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T13071</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322192.1">
        <property type="nucleotide sequence ID" value="XM_011323890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RI88"/>
    <dbReference type="EnsemblFungi" id="CEF78339">
        <property type="protein sequence ID" value="CEF78339"/>
        <property type="gene ID" value="FGRRES_03517"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03517"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13071"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="InParanoid" id="I1RI88"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124205" evidence="7">
        <location>
            <begin position="25"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="8">
        <location>
            <begin position="48"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF78339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="348" mass="39170" checksum="A12CF4451910199C" modified="2012-06-13" version="1">MSFVRAFSFLTAVSLVTYTILSIATSFGPAEMPEFNKNETVRDIPAFGLGTWLAGKGVVVPAVEYALKGGYRHIDTALIWRNEDEVGKGIKASGVSRDEIWVTGKLWNTDHRPELVRKAIETSIANLGVEYLDLYLIHYPVAWVPETRDVDNNTSLIDTWKAMEELVRAGLTRNIGFSNFAPKDINKILKIASIQPYAHEFETHPYLQQQSFVDFHKKENIKVIAASPLANTNPTYGDKYPSILHDEFWVKLAEDKNATVAQTILAWGQQRGTIVISKSTHSNHIAENLCSQGIEFTKSELEEVAKQDKKLRLLNPIHWGMDLFEGLDAGAAEKEEPKKEEDERNLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJB9</accession>
    <name>I1RJB9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FGRAMPH1_01T14059</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321737.1">
        <property type="nucleotide sequence ID" value="XM_011323435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJB9"/>
    <dbReference type="STRING" id="229533.I1RJB9"/>
    <dbReference type="KEGG" id="fgr:FGSG_03930"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14059"/>
    <dbReference type="eggNOG" id="KOG0756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_5_1_1"/>
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    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF3">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="31"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="128"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="223"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SCB65880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="310" mass="32407" checksum="C53190E5A87AAA05" modified="2012-06-13" version="1">MDAAQAQQPIAQQLPKQLTAPKITPQQKKKITPGISLAAGAVAGGIEATITYPFEWAKTVAQLGARQPGVKTSRSPFAVIGTTIRSDGVRAIYTGCSSLIAGTAAKAGVRFLTFDTVKAQLADSNGKLTPGKNILGGMIAGAVESVTVVTPTERIKTALIDDARSGTKRLNGGFHALRTIAAERGIREIYRGLTSTTLKQSATSGVRMGSYNILKEFVGPDAKNPFVTFGIGAVAGVITVYATQPFDTIKTRSQSAKGVSMGEAFRAVVRDGGVRAFWSGSTMRLGRLILSGGIVFTAYENIAALLMGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJP6</accession>
    <name>I1RJP6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG04075.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T14411</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321569.1">
        <property type="nucleotide sequence ID" value="XM_011323267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJP6"/>
    <dbReference type="EnsemblFungi" id="CEF79008">
        <property type="protein sequence ID" value="CEF79008"/>
        <property type="gene ID" value="FGRRES_04075"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04075"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14411"/>
    <dbReference type="eggNOG" id="ENOG502RKPI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1384280_0_0_1"/>
    <dbReference type="InParanoid" id="I1RJP6"/>
    <dbReference type="OrthoDB" id="5082783at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF79008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="197" mass="23505" checksum="F194CA38989CC1AA" modified="2012-06-13" version="1">MSFEIDNLKATINRYIIARMFYHNPHSKFFSLGKEYFEFRSEEIYRAWVAVTNDQRLQGALTPDDLILLYLCMVQYKWWRDLVRGYEYRFNSNLLEEYENFKGDLRGNFEEAFWLFYTRTCFGSHPWMDDISESCLPEDTSERGRHSPTAGPYSTFQPPVGNPDNSDNTERQLRHVRRETSVISETDDLIDLVELYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1RMV5</accession>
    <name>I1RMV5_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U2 small nuclear ribonucleoprotein A'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG05305.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T17577</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323817.1">
        <property type="nucleotide sequence ID" value="XM_011325515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RMV5"/>
    <dbReference type="FunCoup" id="I1RMV5">
        <property type="interactions" value="1288"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RMV5"/>
    <dbReference type="EnsemblFungi" id="CEF87291">
        <property type="protein sequence ID" value="CEF87291"/>
        <property type="gene ID" value="FGRRES_05305"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05305"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17577"/>
    <dbReference type="eggNOG" id="KOG1644">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_061027_1_0_1"/>
    <dbReference type="InParanoid" id="I1RMV5"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="C:U2 snRNP"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="U2 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Leu-rich_rpt"/>
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        <property type="entry name" value="RU2A"/>
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        <property type="entry name" value="LRR_9"/>
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        <property type="entry name" value="L domain-like"/>
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        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF87291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="243" mass="27134" checksum="8FF89429B24B0570" modified="2012-06-13" version="1">MRLTADLIRDSLSYLNPLKERELDLRGHRIPAIENLGVAGPHDAIDFTDNDIQVLGNFPLSPRITTLLLARNRVSSIQPSLAKAIPNLANLVLSSNNLVELADLDALASFPRLTHLVLSDNPVSKKENYRYWVLWKCPSVRFLDFVKVKESEREQARELFGTEEEPTALAAKIQGIKTTNFSTSADGSEAPSKLSRIKLTDAEKKRLQERIKKATSLQEIIALEKELNEGRLPSGIHGDAMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>I1RN17</accession>
    <accession>A0A098DYP1</accession>
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        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
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    <gene>
        <name evidence="4" type="primary">FG05376.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T17759</name>
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    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323900.1">
        <property type="nucleotide sequence ID" value="XM_011325598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RN17"/>
    <dbReference type="FunCoup" id="I1RN17">
        <property type="interactions" value="1129"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RN17"/>
    <dbReference type="EnsemblFungi" id="CEF86975">
        <property type="protein sequence ID" value="CEF86975"/>
        <property type="gene ID" value="FGRRES_05376"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05376"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17759"/>
    <dbReference type="eggNOG" id="KOG2076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002391_0_1_1"/>
    <dbReference type="InParanoid" id="I1RN17"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
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        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
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        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
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        <location>
            <begin position="414"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="876"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF86975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="934" mass="105912" checksum="CE4FC55C0E1DFBEE" modified="2012-06-13" version="1">MDMMERQHENASDADSDLEELEDDIAKFDQTVRNFINEQRDEVVPPSANRSGLRGKGARGPRKAAKPRGDITARLSKVNQAFLSGDYSLALDLVFEVIRINAETHQAWTTLASIFGEQGDMSKSLSAMVYAAHLRPKDVNGWLRCASFALENTSDDEAGNLNTARLCYSAALRADHTNLDARLGKGLVCHRQGHLAAAISDYKVVLKHRPYDLEIVRKLAEACVDNKQAEAAVPSAIAAYKRFFDHEKKETSLEMIESPWTDIGIYVELFASTGRYQDAIQEAKALARWVLGRESEGYWNNWHSDDREWDMDDERRTGVPEFRAGLWSTDLYGRSFPLDLRARLAIYRFRLGDEEEAMKHLWWFDPESVITRDFANEFPFLTFDLAEELAHRGHTPLAISYYHVLRDLPGDADATILLQLGRCHSAIGENATAEEYFLAAIDADEDNIDARIELANMYEKAREEEEALILAAEAMALREIRDRDHNNESGQDSSTATEQPSRRAPRRTQAVPRRTDAFGKRLITRRYRPKRLAGAEKRRQEEQARAVKLAEQYEIVQDLRQKIKGGCQDLVPEWMASSKELVDDFRSIKKFYTWDKYLHFLGPKNHTQQQEAGQPQNELSQMYERLARTLAPQPDNGNGEAGSSDLESHRGISFNNWLDLFLDYAIGLAIAHRRDEAYQVCEAARDSTAFQAPEHGFIIHIAWSVCAIYTSDEEKCIATARQLMRDGATSDSYRMFALVSNLCQSPVSWYTSGPAQKYILRQIKAMDEAYGESEPNEDSAKKREPSLDACVLMLYGHILFTSTSYTYALGYFLRSRALDPDNPMVNLSLGLAYVHYGLKRQSTNRQYLLLQGQSFLSRYAELGSSSPVQDSSQNKAEAYYNLGRLYQLLGINYLALEYYSRAKKVLQSHRGHADALGGLENNKALPLLKGRIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1RNJ5</accession>
    <name>I1RNJ5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG05578.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T18249</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324131.1">
        <property type="nucleotide sequence ID" value="XM_011325829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RNJ5"/>
    <dbReference type="FunCoup" id="I1RNJ5">
        <property type="interactions" value="555"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RNJ5"/>
    <dbReference type="EnsemblFungi" id="CEF87259">
        <property type="protein sequence ID" value="CEF87259"/>
        <property type="gene ID" value="FGRRES_05578"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05578"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18249"/>
    <dbReference type="eggNOG" id="KOG3324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063935_1_1_1"/>
    <dbReference type="InParanoid" id="I1RNJ5"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF87259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="241" mass="25397" checksum="78BDA0FB56105AB4" modified="2012-06-13" version="1">MGSIWNAFTGGNKSGHQQQQQQQSQSYSQPTTQEPAHYSSYDPTEGQGVESFLQSSTFADPSQLHPLAGLNRDTLEYISLEDSALSELPGGQSVLPSRGFTDDLCYGAGVTYLGGLGVGGAWGLQEGLRRSAGQPPKLRLNAVLNSVTRRGPFLGNSLGVVAIIYNCTNSLIGSLRGKHDAGNTILAGALSGMLFKSTRGLRPMAISGGIVASVAGVWAIVRRSFFPIPEAVTPVSDELTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1RNU0</accession>
    <accession>A0A098E1C9</accession>
    <name>I1RNU0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG05680.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T18501</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324253.1">
        <property type="nucleotide sequence ID" value="XM_011325951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RNU0"/>
    <dbReference type="STRING" id="229533.I1RNU0"/>
    <dbReference type="EnsemblFungi" id="CEF87895">
        <property type="protein sequence ID" value="CEF87895"/>
        <property type="gene ID" value="FGRRES_05680"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05680"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18501"/>
    <dbReference type="eggNOG" id="KOG2515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025462_0_2_1"/>
    <dbReference type="InParanoid" id="I1RNU0"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF87895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="399" mass="46109" checksum="C7298C13CA2F746B" modified="2012-06-13" version="1">MELSLSSLGYHEVVVLLSIITGLGLFVYKVHDTIQSRRSFRSKSKLPPVSANYTPSDYKTPVPEPYPNWSIDDTKPLPYRAFRHGPTYQATMGLRTCPVEEWIELDNHFPKYHADKAKRIAERGTKCVDTHPDAYPAAIELLEEMADYLPARYPSLFERTSVGIKNKWSGEDFNIVERPLAEDPMAICARLVQDDLAIMIERPDGQYYLLAGAILLAGFWRMSDKYGMSLSEIHTSGDVPHFKEKLETGMCKFFKRLRPETVYNRNNYFVQVDDDLAWSWSIGSEDSLSVSWSTAEKNRAIEHHMFRSERQSLRRLPKTGAVAFTIRTYFHPVTDIVKEDYVPGRLASAVRSWDDKVANYKGRQKYGEVLLEYLDKEHEKQVARGLQVDKEHEVRRYPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1RP63</accession>
    <accession>A0A098DY53</accession>
    <name>I1RP63_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG05816.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T18825</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324409.1">
        <property type="nucleotide sequence ID" value="XM_011326107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RP63"/>
    <dbReference type="EnsemblFungi" id="CEF86279">
        <property type="protein sequence ID" value="CEF86279"/>
        <property type="gene ID" value="FGRRES_05816"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05816"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18825"/>
    <dbReference type="eggNOG" id="ENOG502SRWX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057547_4_2_1"/>
    <dbReference type="InParanoid" id="I1RP63"/>
    <dbReference type="OrthoDB" id="4500473at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF86279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="232" mass="25564" checksum="F403A8D684D0C67A" modified="2012-06-13" version="1">MVKEYFLAPNYTTAAEGPIKLGSILRNITEFEPLNQVVETIPATQLYPVDVKEQFEISLHELHSVNLNLKARALGLLGLGTGASIERVKGSNDVISCHRLETLSFNPTDSYIEASMEDSNVKRFMRSSRFRKPIYMVTGLKIARAAFRTSSTNSLVAVEHNTSLLPPGAPVAVGGTVKKIWLDRKNKVKQGGYRKMAVMQGETSVGESPFAVRSDDDLTPGEVEEMFSQAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1RPI3</accession>
    <accession>A0A098E0H8</accession>
    <name>I1RPI3_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-intron lyase</fullName>
            <ecNumber evidence="2">4.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">tRNA-intron endonuclease Sen2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG05954.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T19153</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324565.1">
        <property type="nucleotide sequence ID" value="XM_011326263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RPI3"/>
    <dbReference type="FunCoup" id="I1RPI3">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RPI3"/>
    <dbReference type="EnsemblFungi" id="CEF87124">
        <property type="protein sequence ID" value="CEF87124"/>
        <property type="gene ID" value="FGRRES_05954"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05954"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19153"/>
    <dbReference type="eggNOG" id="KOG4685">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012847_1_0_1"/>
    <dbReference type="InParanoid" id="I1RPI3"/>
    <dbReference type="OrthoDB" id="10249562at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016589">
        <property type="entry name" value="tRNA_splic_SEN2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011789">
        <property type="entry name" value="tRNA_splic_SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="10">
        <location>
            <begin position="466"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="322"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="496"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="504"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR011789-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF87124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="594" mass="65472" checksum="2C6BE64470AC6891" modified="2012-06-13" version="1">MAEIQSSNTKPVGTAPTTDSAGQRQSQQRGPSLHQIYALPAPIRTFPLPAFYPSNPISLFHVAYAWLGQLWSPPKAEPSAVHIGTWSAATSSVHITDDVSTRALWEQGFYGKGSLSRSEPNWLKREQVRQGLADAHVSEIMTVQRRQERMRAKWERARLEQEVIRETRLKEAEEAKAREAKVLKAEEMKLRSQESKDIATPESDKPISLPAALPTYESPVSPAALLSLPNSLADLVQPKSIQPVTPVVSVPTYASPVCPQTILSLPNSATDIANKPVGEKAAEEFNIFGISGSHMAGLGLSVDTARSNSANGVVANGAASVISSSSDDEGTRRPKSRRKSVRFSPTVESTTFYFADPPSPKRAESNGKLNGLSDGRPISPVALNGRKEDAKTEIVSKPVLKNMEHLQLMPEEAFFLNFGLGALQVTDPASGSQLSSLDLLRLFRQHSYFPPRVEAEDPALQPDDNFLVHYAVYHHFRSLGFVPRGGIKFGVDWLLYTRGPVFDHAEFGLIVIPSYSDALWKESGKQNPQKTWQWLHGTVRVLSHVTKSLVLVYVDVPPPSKLEQALEKGVAEALKLYKVREVMVKRWSTNRNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RPQ9</accession>
    <name>I1RPQ9_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T19339</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cell membrane</location>
            <topology evidence="1 5">Lipid-anchor</topology>
            <topology evidence="1 5">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324655.1">
        <property type="nucleotide sequence ID" value="XM_011326353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RPQ9"/>
    <dbReference type="FunCoup" id="I1RPQ9">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RPQ9"/>
    <dbReference type="KEGG" id="fgr:FGSG_06037"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19339"/>
    <dbReference type="eggNOG" id="ENOG502QRZZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021855_1_2_1"/>
    <dbReference type="InParanoid" id="I1RPQ9"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF4">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010392540" description="1,3-beta-glucanosyltransferase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="418"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SCB64853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="491" mass="53842" checksum="697EF7A16FB043F8" modified="2012-06-13" version="1">MLINAALMALGAAVVGAVPPLEIQGTDFVNPETGNKFQIVGMAYQPGGSAGYDPATGKDPLSNKDKCMRDAALMQILGINAIRVYNLDPNVNHDECASIFNAAGMYMMIDVNSPLPHESLHSLAPWESYHADYLNRTFAIVEAFGNYPNTLLFFAANEVINDEKTAEDAPQYIRALTRDLKNYVKNNLKRKIPIGYSAADVREVLWDTWNYLQCSDPEDEGDMSRADLFALNSYSWCGPEATYETSSYNDLVAGFESSSVPIFFSEYGCIEPAPRYWNETQAIYGKQMSSVFSGGVVYEYTEEENNYGLVKIDDDKVRILGDFNRLKNQFARIKWESVQSNPAGKNSSAKAPECKSSLIKDSNFDSNFTIPDVPPKAQGLIDNGIKNKPSGKIVKISDWNVKLDVMNADGSAMKNLKVVPLKDDESNASGNNDADTGSETTDDKNSTDSDNKTSSSSGDAKDGDDDEDAAGLNRPLAWAMAFPLAVMMFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RPT5</accession>
    <name>I1RPT5_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cytochrome c oxidase assembly protein COX20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG06064.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T19397</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the assembly of the cytochrome c oxidase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the COX20 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324686.1">
        <property type="nucleotide sequence ID" value="XM_011326384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RPT5"/>
    <dbReference type="FunCoup" id="I1RPT5">
        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF87811">
        <property type="protein sequence ID" value="CEF87811"/>
        <property type="gene ID" value="FGRRES_06064"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06064"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19397"/>
    <dbReference type="eggNOG" id="ENOG502S3BD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101495_0_1_1"/>
    <dbReference type="InParanoid" id="I1RPT5"/>
    <dbReference type="OrthoDB" id="14603at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022533">
        <property type="entry name" value="Cox20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586">
        <property type="entry name" value="CYTOCHROME C OXIDASE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12597">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007871">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF87811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="170" mass="18725" checksum="AE44D3C8456814D0" modified="2012-06-13" version="1">MASNPQGGQPQPGDKTLHVWSKPIEQNGAAAATNAENGATSTNTRPTISEAVSMIKKDDFANIANTPCARQGFITGIASGAGIGGLRFVVKGNAGSAANWAVGVFVLGSMASYEWCQYQRREERRQMKRHIEVVSENRREQARKIQEARREHDKLEAEKKAAVKPWYKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>I1RS15</accession>
    <name>I1RS15_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG06919.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T23497</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
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    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326586.1">
        <property type="nucleotide sequence ID" value="XM_011328284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RS15"/>
    <dbReference type="FunCoup" id="I1RS15">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF85266">
        <property type="protein sequence ID" value="CEF85266"/>
        <property type="gene ID" value="FGRRES_06919"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06919"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23497"/>
    <dbReference type="eggNOG" id="ENOG502QWBM">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_031468_2_1_1"/>
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    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ApbA_C"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="10"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="201"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF85266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="330" mass="35903" checksum="F4D802039EFEFECA" modified="2012-06-13" version="1">MDKVNGKARILVVGCGGIGGMAALNLEFGGQAQVTAVLRSSYQIVEKQGFTINSVDHGQVRGFRPTEILSAVPDVSPSGLLPFDYIICATKNTPDVSMPVAELIRPAVTTGYSTILLLQNGLNIEVPLLEAFPDNVILSGISVCGSSEPESGTIEHNVHDELWIGPFRDVGNAADRAKDIVTRYNAGGRCTCHYDSNVTFSRWKKLLYNAVYNPVAALTRLDTGDLQLCPGLVDEVVRPGMKEIQAAAAAYGQEITDEMVEATITTEPIDAHVSPSMLVDVRKSQYIEFENLIGEPLRRAKARQIATPILQNHYSLAKSYQWKLKSKRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1RSG4</accession>
    <accession>A0A098DMJ1</accession>
    <name>I1RSG4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG07082.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T23917</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326783.1">
        <property type="nucleotide sequence ID" value="XM_011328481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RSG4"/>
    <dbReference type="EnsemblFungi" id="CEF83075">
        <property type="protein sequence ID" value="CEF83075"/>
        <property type="gene ID" value="FGRRES_07082"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07082"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23917"/>
    <dbReference type="eggNOG" id="ENOG502RP9X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1482030_0_0_1"/>
    <dbReference type="InParanoid" id="I1RSG4"/>
    <dbReference type="OrthoDB" id="4939977at2759"/>
    <dbReference type="PHI-base" id="PHI:1586"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF83075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="180" mass="20181" checksum="B4AFC1519CD49A10" modified="2012-06-13" version="1">MPQMADRRPALTLPLPDREQSDFQRPQSSLQTPPIRSPRFREDFDAPFSVDIMNASRITLATDTMSYPSTGTNSRNSFGYDETPPQYLRNASWESETKRRSKVNDRILEWAKKSWGAVRTRSDSKFDYFDSHSAQSPTSDIMSPSSENITPSEPDGSQAANDYTRAVTVTVMASSKAGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RSH4</accession>
    <name>I1RSH4_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG07093.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T23941</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326793.1">
        <property type="nucleotide sequence ID" value="XM_011328491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RSH4"/>
    <dbReference type="FunCoup" id="I1RSH4">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RSH4"/>
    <dbReference type="EnsemblFungi" id="CEF85353">
        <property type="protein sequence ID" value="CEF85353"/>
        <property type="gene ID" value="FGRRES_07093"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07093"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23941"/>
    <dbReference type="eggNOG" id="KOG2730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029658_0_1_1"/>
    <dbReference type="InParanoid" id="I1RSH4"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000270">
        <property type="entry name" value="RNA methylase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF85353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="259" mass="29598" checksum="457160E5A2A5B42B" modified="2012-06-13" version="1">MSVENPEYTMKPAEELPLTDQCHHYEGKHEVPWDIQKYFSQRYSIFSLYDYGVYMTDDAWFGVTPEPVANQVANDMYGTDEKKHILIDAFGGAGGNTIAFTLSERWSRVISIERDPSTLACAQNNAKVYGIEPGLITWILGDSFEYLDKLFNRPEELHPDLRVNLDETVLFSSPPWGGPGYRTDEVFNLYNMQPYNLDDLHNAYNRLDHALFLPRTSDIRQIAKLAPSDRKVEVVQYCMEGASKALVAFLPSKSSKKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1RTE1</accession>
    <name>I1RTE1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG07444.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T24835</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327216.1">
        <property type="nucleotide sequence ID" value="XM_011328914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RTE1"/>
    <dbReference type="EnsemblFungi" id="CEF85261">
        <property type="protein sequence ID" value="CEF85261"/>
        <property type="gene ID" value="FGRRES_07444"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07444"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24835"/>
    <dbReference type="eggNOG" id="ENOG502S7FM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042952_0_0_1"/>
    <dbReference type="InParanoid" id="I1RTE1"/>
    <dbReference type="OrthoDB" id="5327145at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF85261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="430" mass="47423" checksum="9812AFED1C66D767" modified="2012-06-13" version="1">MLAAHRDQENLVLSQQVPTKQGHNSRFPKTPSRFPQRDENAPAAFTGKGGVKTINKGNGTRQAMITPMGTRSRAPLGNKTTNAKAKNGQLGGVKNLVKDIEQTQLKPTAQKPKQRPVGLAPLEIRLKEEQKTFEPQEEEPEYAPPKPKDLPYESDCFPKDMLTLDGLKKGNLLKGYYQHFYNPVDDEGISRQDREFAETMKKVAARAEEKNKRETDALTFNIDDLSDDEEQVKKPAPKSSLLDASGRKTNGIRTKQPSSLASRRAASALSIHSDTSSNSKGPTMARPTGIRKPLTSLYQGRKPAARNIVPVKRSHAESATGEAASRTTIGYNRGRSASSLISARRCGTDVRGGTQRLVKPSGTVSPTQSDLTITPSRFSQAVQKDQETKPLPQFMSIFDEDGDDDDLPPLSQPLHISDDEDEEFELKFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I1RTN3</accession>
    <name>I1RTN3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">FG07544.1</name>
        <name evidence="17" type="ORF">FGRAMPH1_01T25063</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327322.1">
        <property type="nucleotide sequence ID" value="XM_011329020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RTN3"/>
    <dbReference type="STRING" id="229533.I1RTN3"/>
    <dbReference type="EnsemblFungi" id="CEF83200">
        <property type="protein sequence ID" value="CEF83200"/>
        <property type="gene ID" value="FGRRES_07544"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07544"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25063"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010189_4_1_1"/>
    <dbReference type="InParanoid" id="I1RTN3"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="BCS1 N-terminal" evidence="16">
        <location>
            <begin position="33"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="276"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="508"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="529"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CEF83200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="561" mass="62324" checksum="7C88580A96E05066" modified="2012-06-13" version="1">MASSARMPSRRLFAGGAINRLLDLLLPGGSGITSVAFFAYIAPYLIEVATDVFQRQCVSTIEIQGHDEIFTYLMSWVARNNKLSRNNHRLLASSSTSNEPSHPMRGPPRGNENNEEDDSGDDIDPSASLDVLRSKISLYNARPLHWTPSVGTHWFWYENRVVSFTRTAANETPMPFGLRFETVVLSCLGRNPDILKRIIYNARIEYLEKQRGRTSIFRAVQSHGEMHCWARSMSKPTRPMSTIALEEDKKQSLIKDLARYLNPRTKKWYATRGIPYRRGYLFSGPPGTGKTSLALAAAGLMGLNIYMISLSSPTLSEDSLASLFQTLPRTCLVLLEDIDAAGVAASRVEQQKAKAESAGKPRRPGFGFPMISREPITLSGLLNVLDGVGAQEGRVLVMTSNHTENIDPALLRPGRVDYTIKFGLASFETIKQLFQLMYGTSYAETGIELDSENIEALSTEFAQVVPAHTFTPAAIQGYLLMHQDGPSEAVAEAGVWVEEQKRLKEKAEEIEKVEAKEEEDKNESETENDEKTKDKKNPEAKIKVNGVKMSDLLGDLANDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1RTU4</accession>
    <accession>A0A098DWA3</accession>
    <name>I1RTU4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG07611.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T25213</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327396.1">
        <property type="nucleotide sequence ID" value="XM_011329094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RTU4"/>
    <dbReference type="EnsemblFungi" id="CEF85153">
        <property type="protein sequence ID" value="CEF85153"/>
        <property type="gene ID" value="FGRRES_07611"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07611"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25213"/>
    <dbReference type="eggNOG" id="ENOG502S43F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096872_3_0_1"/>
    <dbReference type="InParanoid" id="I1RTU4"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
        <property type="entry name" value="UPF0311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315:SF1">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF85153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="197" mass="21851" checksum="85D8F50360EEE878" modified="2012-06-13" version="1">MSSKTILSEAKAHVPSPGNDYEPSLPRMRMPHLEFIYRIVAEMDKSGVEAIEGVDSSDKNRLYLPIQGGSVHGPQIKGVILHKSGADWAEVLNPKKSFIRLNAMYMLKTDDNVHILVKAQGVYRTGPGLEDKLGEQDTASQDDVEYFTHIRFEAPGNSEYGWMNGVVAIGVMTMWQGKPVIDCYRLTNFPGKVAANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RUN8</accession>
    <name>I1RUN8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG07938.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T26029</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327780.1">
        <property type="nucleotide sequence ID" value="XM_011329478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RUN8"/>
    <dbReference type="FunCoup" id="I1RUN8">
        <property type="interactions" value="1260"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RUN8"/>
    <dbReference type="EnsemblFungi" id="CEF83566">
        <property type="protein sequence ID" value="CEF83566"/>
        <property type="gene ID" value="FGRRES_07938"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07938"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26029"/>
    <dbReference type="eggNOG" id="KOG3151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046003_1_1_1"/>
    <dbReference type="InParanoid" id="I1RUN8"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="74"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF83566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="270" mass="30388" checksum="CA2EA8F06DDE847E" modified="2012-06-13" version="1">MAERNLSQIISQLKHSPSMSYTDANALLSKAKLALLKLNALTPSPSTPTQLLPLARETYEQGALFAIRARNPEAFTRYVQQLQPFYELPASVLPPNLLERNKVTGLSLLLLLTQGRYAEFHTELESLENREGGGGDVESDRYLGYPIRLERWLMEGSYDRVWKAMKSSEVPCDEYSVFSEILKNQIRSEIASSSERAYPSLPISSTKSLLFLDSEGDVISFAHHRGWIVRDGHIYFPDAAEGENGDQNKEMSQMVIENALGYARELETIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RUQ1</accession>
    <name>I1RUQ1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAM1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Outer kinetochore protein DAM1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">FG07951.1</name>
        <name evidence="16" type="ORF">FGRAMPH1_01T26063</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327796.1">
        <property type="nucleotide sequence ID" value="XM_011329494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RUQ1"/>
    <dbReference type="STRING" id="229533.I1RUQ1"/>
    <dbReference type="EnsemblFungi" id="CEF85486">
        <property type="protein sequence ID" value="CEF85486"/>
        <property type="gene ID" value="FGRRES_07951"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07951"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26063"/>
    <dbReference type="eggNOG" id="ENOG502S08R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083960_0_0_1"/>
    <dbReference type="InParanoid" id="I1RUQ1"/>
    <dbReference type="OrthoDB" id="5586015at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990537">
        <property type="term" value="C:mitotic spindle polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013962">
        <property type="entry name" value="DASH_Dam1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08653">
        <property type="entry name" value="DASH_Dam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="111"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CEF85486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="204" mass="22553" checksum="F3498C9DE5AD3E13" modified="2012-06-13" version="1">MSMTPKDAAKRPNSRSRTSRPTTPLRPSSRSSFRDSARSARHHDAPFPLNAFEPAFAELSDAMADLETNMMHFQLMHESLARFSESFASFLYGLNMNAFCVDFPEGPVPESFRRDRTRQEQPAVTPSKSEADAEMTFMTTDGSFVENPPTTTKTSKFTTPEPPKRQSRLPAAPGRGTTARGRSTRGVGRGRPSGLARARGRGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1RV61</accession>
    <name>I1RV61_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG08123.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T09163</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320695.1">
        <property type="nucleotide sequence ID" value="XM_011322393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RV61"/>
    <dbReference type="EnsemblFungi" id="CEF76384">
        <property type="protein sequence ID" value="CEF76384"/>
        <property type="gene ID" value="FGRRES_08123"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08123"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09163"/>
    <dbReference type="eggNOG" id="ENOG502S0NM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_4_1"/>
    <dbReference type="InParanoid" id="I1RV61"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052718">
        <property type="entry name" value="NmrA-type_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129:SF1">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="312" mass="34419" checksum="6BDEB4476F94D6FE" modified="2012-06-13" version="1">MQIGIFPASGALGTSTYTHLLSQVPNDKVTLINRYPEKVPKKYIEKGTTVRQASYESSAEDLEAVFSGVDVLFLISYPSHVHEYRTKVHTKAIDAAVKAGVKHVFYSSLGFASLGKDFTKAEVMGAHLDSEKRLKELAERNSGFTFTSVREGLYSESFPIYTSFLDLKNPPSKVLIPHDGSGPGVSWVKRDELGEGTARLIASYAESPSTFGYINKIVTLTGTKSFSLAETMEVLSRAAGKNFEIQQISVEEYTNLPQIKEYFGTEEKATTWATAWEAIRAGETAGVTTKLKELLGREPESFEKTIGEFVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1RV89</accession>
    <accession>A0A098DBU8</accession>
    <name>I1RV89_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG08154.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T09243</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320659.1">
        <property type="nucleotide sequence ID" value="XM_011322357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RV89"/>
    <dbReference type="EnsemblFungi" id="CEF76424">
        <property type="protein sequence ID" value="CEF76424"/>
        <property type="gene ID" value="FGRRES_08154"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08154"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09243"/>
    <dbReference type="HOGENOM" id="CLU_1627189_0_0_1"/>
    <dbReference type="InParanoid" id="I1RV89"/>
    <dbReference type="OrthoDB" id="5101513at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="163" mass="19006" checksum="C806F6BA35F7BB1F" modified="2012-06-13" version="1">MNTSSLQNAFEAQMTKAYCPDAPTPGYLWDPILHVWRSLDSEKALHCGYMAIVPDVELNDRLPWWNWNNLSQSVEYWRTYGRYAKRSQILGLIEYIRYDHAYEILNEGYDEDDGIEDTRPEAAEALLLEVIARSEEDGDDDFGTDNGDSDDDDYEYDYESDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I1RVW5</accession>
    <accession>A0A098DCS4</accession>
    <name>I1RVW5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG08412.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T09891</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320364.1">
        <property type="nucleotide sequence ID" value="XM_011322062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RVW5"/>
    <dbReference type="EnsemblFungi" id="CEF76748">
        <property type="protein sequence ID" value="CEF76748"/>
        <property type="gene ID" value="FGRRES_08412"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08412"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09891"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="InParanoid" id="I1RVW5"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF172">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF76748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="528" mass="60210" checksum="D11CD47A90DEDD24" modified="2012-06-13" version="1">MYAQLVTASTALCLVTYFILYPIFQYLRDAKGLRRYPNFHPLAGVTNLPFVREAARGFRSKTLYEMHKTHPVIRTGPNSLSYGSVQAIKDIYGHGTKCTKGEFYETLAGTHYHLADVVDKADHARKRRALSAAYALKNLENWEFKVADKAERFIRAADAACTLPLKRGFARPGPEDLKFDYRAFTNFFTLDAIADIGLSERLGFLDQGHDLVKGERMDGSIHHVNFRECLHSTARAQSILAWTEKWYNANVKLSKLFSKDFRKWWNLNEGWNDIVYHRATQRLERYNKGEKLPDFFQALMDHSEANPPGLEWGEIVAEVSIMMNAGSDTTAIAMNNVMYWLLKNPSCMAKLRQEVDSVLDPEEVVAPYDKVKHLPYLRACLDESLRITPPTTFGLPRRTPPEGWNIMGDYVPGDTTVSISAYVAHRDPHIFPDPESYVPERWLGEKGKDLQSYFISFSTGARGCIGRNISYLEQTVLLASVVHRYEWALPYAKWEPSRTEAMNLAPGPMPLKVWRRDLGGDENDEKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1RW57</accession>
    <name>I1RW57_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG08513.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T10145</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320247.1">
        <property type="nucleotide sequence ID" value="XM_011321945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RW57"/>
    <dbReference type="STRING" id="229533.I1RW57"/>
    <dbReference type="EnsemblFungi" id="CEF76876">
        <property type="protein sequence ID" value="CEF76876"/>
        <property type="gene ID" value="FGRRES_08513"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08513"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10145"/>
    <dbReference type="eggNOG" id="ENOG502SDF2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041927_0_0_1"/>
    <dbReference type="InParanoid" id="I1RW57"/>
    <dbReference type="OrthoDB" id="5424234at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="502"/>
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        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
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        <location>
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        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
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        <location>
            <begin position="253"/>
            <end position="269"/>
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            <begin position="285"/>
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    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="502" mass="54397" checksum="DDEA138FE6BE27CA" modified="2012-06-13" version="1">MDPSMPMILPKGIVTNSENIYKEVADFPIVPPDKVWKYWHVYTTTYKKLQDPTACRLENFWWHVWGSDRRFLKGSALAKLYEEISNGPTFVPLKGPPNRWEGPDMHPLIKQILEAAEAQATPPLPQPQGSRSSRPTDSALRTLSSSASKPPPTHPILKKVRGPSASGPRPTARFVSPQESADEDEIPSSGSTAATASEAPAYVTASPMKKTTIPPQKFTPSSPLANKKISPSKKSTSTAEPLIRETGFGTSGGSRSAALQQPAPHNTRTTVERDQPTSGQSNGVVKERPVMSEKARGKRPAASIRPSSHRKDVVKDVIAEETQQTSPSKDRPRSIHREKGVLPQARSLISLTTNGSRRGSRTSSVSTFNVGSLESSQSQDPPAMARSQSHGGYDQHKLQNGIRAPGLFTEATSSTSNVAVAGTILDQSGFGSTSDLNNLDHRRPEHHTIPAVPPRPSILDARFTPTPPTTSASVPLGRTKSQLTLLLEREKARGSDKPRSKN</sequence>
</entry>
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    <accession>I1RX09</accession>
    <accession>A0A098DFR8</accession>
    <name>I1RX09_GIBZE</name>
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        <submittedName>
            <fullName evidence="5">Chromosome 2, complete genome</fullName>
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        <name evidence="6" type="primary">FG08850.1</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319862.1">
        <property type="nucleotide sequence ID" value="XM_011321560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RX09"/>
    <dbReference type="FunCoup" id="I1RX09">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RX09"/>
    <dbReference type="EnsemblFungi" id="CEF77297">
        <property type="protein sequence ID" value="CEF77297"/>
        <property type="gene ID" value="FGRRES_08850"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08850"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10991"/>
    <dbReference type="eggNOG" id="KOG3601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064525_1_1_1"/>
    <dbReference type="InParanoid" id="I1RX09"/>
    <dbReference type="OrthoDB" id="6250593at2759"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3-like_dom_sf"/>
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        <property type="entry name" value="SH3_domain"/>
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    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
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    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 1"/>
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        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="118"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
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        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF77297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="271" mass="29063" checksum="DCC64F12FC4F94EF" modified="2012-06-13" version="1">MSADRQTIIEVNRSLRNIKNELENLLERGVIDDSVYDTINVALPPESSLSGPLRTATGAANKTAAKAVSPAPTSSPAPSAKAAPTKAFNDLKIKSSSPAPPAYDQTPPPGLPTRNVKPTVAHARALYRYAASDGRDLTFEKDDRIAVYEYMNQDWWMGLNERTGQEGIFPRNYVLVDQETKKPVQPMQAPIPQPQYGYPAYSQGPPPQQNPYNAHVPPMAVAEGSGQPAQEGDGKDNKVNEYGKKFGKKLGNAAIFGAGASIGSGIVGAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I1RX11</accession>
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        <submittedName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319859.1">
        <property type="nucleotide sequence ID" value="XM_011321557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RX11"/>
    <dbReference type="EnsemblFungi" id="CEF77301">
        <property type="protein sequence ID" value="CEF77301"/>
        <property type="gene ID" value="FGRRES_08853"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08853"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10997"/>
    <dbReference type="HOGENOM" id="CLU_164185_0_0_1"/>
    <dbReference type="InParanoid" id="I1RX11"/>
    <dbReference type="OrthoDB" id="10500385at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF77301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="144" mass="13913" checksum="FD6A0D49EAA55573" modified="2012-06-13" version="1">MPESSDSQEVASYTPDIFKIPLTISTHVAAGVALLCGVGIGGDVEWSHAVAVGAARASHASHDTHAAVVAAAIAAAVPAVPAVPAVPAVPAVPAVPAVPAVPAVPAGEATAPVVVVVAGATSAAGTPVAASYMSRDSLFSRTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1RXU9</accession>
    <accession>A0A098DPD3</accession>
    <name>I1RXU9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG09175.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T27745</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328606.1">
        <property type="nucleotide sequence ID" value="XM_011330304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RXU9"/>
    <dbReference type="STRING" id="229533.I1RXU9"/>
    <dbReference type="EnsemblFungi" id="CEF83690">
        <property type="protein sequence ID" value="CEF83690"/>
        <property type="gene ID" value="FGRRES_09175"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09175"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27745"/>
    <dbReference type="eggNOG" id="ENOG502SXHQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075359_0_0_1"/>
    <dbReference type="InParanoid" id="I1RXU9"/>
    <dbReference type="OrthoDB" id="5358884at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF83690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="237" mass="25608" checksum="A0EA29A7166022AF" modified="2012-06-13" version="1">MHEQAAKAPEVVHDQNSHYYTPTGYEASTPAGYEALGPKEQRPPFGLGLWGFAGLIAFLTAIIVGAGVGGGLGAALANKSGDSSAEPTSCPTLDNSTSDTAPYVPKAASDVTNLQLNCPEKLSDEQSHFNTGYQFRWWCGVNAPLSEKAKEGGTIFDYVAFFSYSIEDCMGACVNMNTIDDKTHTGLRCRSVVFATNMSAVIETKQYGNCWLKNGTKAKGSNWEFKKRYIAYAELID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I1RYK2</accession>
    <accession>A0A098DTS2</accession>
    <name>I1RYK2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG09458.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T27035</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328268.1">
        <property type="nucleotide sequence ID" value="XM_011329966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RYK2"/>
    <dbReference type="EnsemblFungi" id="CEF84757">
        <property type="protein sequence ID" value="CEF84757"/>
        <property type="gene ID" value="FGRRES_09458"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09458"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27035"/>
    <dbReference type="HOGENOM" id="CLU_2171328_0_0_1"/>
    <dbReference type="InParanoid" id="I1RYK2"/>
    <dbReference type="OrthoDB" id="10453432at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF84757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="110" mass="12538" checksum="F0F5DB31BADE555E" modified="2012-06-13" version="1">MYILITQENVEHFSPLNRYLTTGSPETECYHVIGHEQLHSLSLERRQAEKAYFGQKVVQVTGSWPLFLCRFVLGSYITVAAILILRAHVRSLGIPFDSGTLVQHAIVIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>I1RYX6</accession>
    <name>I1RYX6_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6 18">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">FG09589.1</name>
        <name evidence="22" type="ORF">FGRAMPH1_01T26727</name>
    </gene>
    <organism evidence="22 24">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="23">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="24">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="23">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="22 24" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="22">PH-1</strain>
        </source>
    </reference>
    <reference evidence="23" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 18">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6 18"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328121.1">
        <property type="nucleotide sequence ID" value="XM_011329819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RYX6"/>
    <dbReference type="FunCoup" id="I1RYX6">
        <property type="interactions" value="244"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RYX6"/>
    <dbReference type="EnsemblFungi" id="CEF83100">
        <property type="protein sequence ID" value="CEF83100"/>
        <property type="gene ID" value="FGRRES_09589"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09589"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26727"/>
    <dbReference type="eggNOG" id="KOG0454">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_0_0_1"/>
    <dbReference type="InParanoid" id="I1RYX6"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="PHI-base" id="PHI:9357"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000007">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000003">
        <property type="entry name" value="3-isopropylmalate dehydratase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012235">
        <property type="entry name" value="3-IsopropMal_deHydtase_ssu/lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002458">
        <property type="entry name" value="PRK01641.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004016">
        <property type="entry name" value="PRK05478.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK12466.1"/>
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        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
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    <keyword evidence="15 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
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    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
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        <location>
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        </location>
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    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="21">
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            <begin position="540"/>
            <end position="662"/>
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            <dbReference type="ARBA" id="ARBA00007185"/>
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        <source>
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            <dbReference type="Pfam" id="PF00694"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF83100.1"/>
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    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="777" mass="84554" checksum="B6526CF54410D3A0" modified="2012-06-13" version="1">MPAPVGTPQTLYDKVFSAHIVDEKLDGTILLYIDRHLVHEVTSPQAFEGLENAGRKVRRPDCTLATTDHNVPTSSRKALKDIASFIEEDDSRTQCVTLEENVKKFGITYFGLGDKRQGIVHIIGPEQGFTLPGTTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQCLITKRSKNMRIQVDGELAPGVSSKDIVLHAIGQIGTAGGTGAVIEFCGSVIRSLSMEARMSICNMSIEGGARAGMVAPDEITFEYLKGRPLAPKYGSETWNNAVAYWKSLQSDPGAKYDIDVFIDAKDIVPTLTWGTSPEDVVPITGCVPDPETFSSESKKAAGRRMLEYMGLTAGTPMEDIPVDKVFIGSCTNARIEDLRAAANVVKGRKVADNIKRAMVVPGSGLVKAQAEEEGLDQIFVDAGFEWREAGCSMCLGMNPDILAPKERCASTSNRNFEGRQGALSRTHLMSPVMAAAAALVGKLADVRKLSHYTHQSAFKARELPAEEPHVDERTKDDSEERELIGDQPQDSEPHTNNLVSAAGSASGLPKFTIWKGTAAALDRSNVDTDAIIPKQFLKTIKRTGLGTALFYELRYKEDGSEDPDFVLNQEPFRNTKTLVVTGPNFGCGSSREHAPWALLDFGIKCIIAPSFADIFFNNTFKNGMLPIRIDNKDDLDAIAAEARANRDIEVDLPSQLIKNAAGETICSFDVEEFRKHCLVNGLDDIGLTMQQEEKISEFERSMTKNTPWLDGSGYLKRPGQGGKLAAKAVPIPKTNRGEEKKEPLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZU7</accession>
    <name>I1RZU7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG09952.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T06911</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318861.1">
        <property type="nucleotide sequence ID" value="XM_011320559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZU7"/>
    <dbReference type="FunCoup" id="I1RZU7">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RZU7"/>
    <dbReference type="EnsemblFungi" id="CEF75260">
        <property type="protein sequence ID" value="CEF75260"/>
        <property type="gene ID" value="FGRRES_09952"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09952"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06911"/>
    <dbReference type="eggNOG" id="KOG4580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141247_1_0_1"/>
    <dbReference type="InParanoid" id="I1RZU7"/>
    <dbReference type="OrthoDB" id="2243669at2759"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF75260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="129" mass="14383" checksum="DBC680DABD79912E" modified="2012-06-13" version="1">MSSQPLLQTTPGKRIALPTRVEPKVFFANERTFLSWLNFTVILGALAIGMLNFGDRVAFISAFLFTGVAMCTMVYALVTYHWRAQSIRMKGQAGFDDRFGPTVLAIILLLAVVVNFVLRITDKSKNHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1S1H4</accession>
    <accession>A0A098DDK6</accession>
    <name>I1S1H4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG10576.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T08447</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF76026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319575.1">
        <property type="nucleotide sequence ID" value="XM_011321273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S1H4"/>
    <dbReference type="EnsemblFungi" id="CEF76026">
        <property type="protein sequence ID" value="CEF76026"/>
        <property type="gene ID" value="FGRRES_10576"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10576"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08447"/>
    <dbReference type="eggNOG" id="ENOG502SIFR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041815_2_0_1"/>
    <dbReference type="InParanoid" id="I1S1H4"/>
    <dbReference type="OrthoDB" id="3434319at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="403" mass="45390" checksum="B471481B247564ED" modified="2012-06-13" version="1">MLGTQCSIGQQRVPGRPRRKQPAKSSIPTSQNPSVNASTLPISPPLVRPNTFFNDEWGLWDRAELLYPILSPPEKPSTTTKDVTATPCGFIDVFHQSDTSWVTSDDTEFSDTPLYANMDTVWDIYRTTTSPTMPLAINDSFSLSNCLTTNHPRNTEPKDIMTDLSTINLGLYTRLEAIKKNGKTLNFDMMISQCGPLFIDNITLLDYIIKVAQEFFFLLTNLYDERHCPSILHNVQPMEVLCPCHLSLRFLNEPRVLFQVSLPLPTVIAEPLPAPVALIIASVFIQLITIYELILNNVATVVERLTIYPMEYVPVLIVCGRKLERPCTQGMIFCEVTVSLIENIERVLGVARKEVGLLSQRQVEVLRDELDERCNVIPGHNVMTPTMLRKLYGKVANILRNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>I1S2A8</accession>
    <name>I1S2A8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG10894.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T20745</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325486.1">
        <property type="nucleotide sequence ID" value="XM_011327184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S2A8"/>
    <dbReference type="FunCoup" id="I1S2A8">
        <property type="interactions" value="1468"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1S2A8"/>
    <dbReference type="EnsemblFungi" id="CEF87967">
        <property type="protein sequence ID" value="CEF87967"/>
        <property type="gene ID" value="FGRRES_10894"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10894"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20745"/>
    <dbReference type="eggNOG" id="KOG2020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011906_0_0_1"/>
    <dbReference type="InParanoid" id="I1S2A8"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nuclear periphery"/>
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        <property type="term" value="C:spindle pole body"/>
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        <property type="term" value="F:nuclear export signal receptor activity"/>
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        <property type="term" value="F:small GTPase binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:U1 snRNA binding"/>
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        <property type="term" value="F:U2 snRNA binding"/>
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        <property type="term" value="P:protein localization to kinetochore"/>
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        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000490">
        <property type="entry name" value="CRM1p Major karyopherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="ARM-type_fold"/>
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    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
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    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
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    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
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    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1049"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1049"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF87967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1079" mass="123703" checksum="8B1468314431C960" modified="2012-06-13" version="1">MAASIEELDVLVRSFYEGRGEQQKAAQAALNQFKEDPDAWLMVDKILSDAQYPQTKYLGLQVLDHVIMTRWKVLPREQCQGIRNFIVQFIIQCSSTEESLRQQKTLLNKLNLVLVSVLKQEWPHNWPTFINEIIQSCHSNLAICENNMIILRLLSEEVFDYSAEQMTSTKTRNLKQTMCAEFSQIFNLCQEVLNTATQPSLIKATLETLLRFCNWIPLGYIFETPLIDTLRTRFLSTPEFRNVTMQCLTEIGGLQTGGPGQPNSYDEELVKMFTETLTTIANIIPVSLDLKSTYPSSNSRDQEFIQNLALFLCNFFGMHLNLVEKLPNRDFLIHGHYYLIRISQIDDREIFKITLDYWLKLVQELYEEMQALPITDLNPLMAVGAGMSGGGAPNPTMLNNYPLRKHKYNEVLSNLRVVMIEKMVRPEEVLIVENDEGEIVREFVKESDTVQLYKTIRECLVYLTHLDVVDTENIMTEKLARQVDGSEWSWHNCNVLCWAIGSISLAMNEETEKRFLVTVIKDLLGLTEMKRGKDNKAVVASNIMYIVGQYPRFLKAHWKFLKTVVNKLFEFMHESHEGVQDMACDTFIKIARQCRRHFVALQPSEQEPFIEEIVRNMGKITCDLTPQQVHTFYEACGYMVAAQGNKHQQERLLSDLMAIPNAAWDEIIKQATVNPSILQDAETIKVIGNIMKTNVSACSSVGSYFYPQIGRIYHDMLQMYNATSTLISEAVARDGELATKMPKVRGLRTIKKEILKLIEVYVDKAEDLQAVRAQMVPPLLDSVLVDYNRNVAGARDAEVLKACSTIITKLSALMEDQVPTIMQNVFECTLEMINKDFSEFPEHRVEFFNLLRAINLHCFPALLKLDNNQFKFVIDSCSWAFKHDNRDVEAAGLNMALELINNIAEKTDVQTANAFFQRFFITILQDVFFVVTDNDHKAGFKTQSMLLMKLFYYINPADGTQPKIQGPIYSPDQAQAGTDNREFVANFVANLLQNAFRNLQTNQIQSFVEGLFTLNTQYDKFRLNLRDFLVSLKEFAGDNAELFVVEKEQQEQEAKNADMERRQKVGGLLKPSELDDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1S2B9</accession>
    <name>I1S2B9_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG10907.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T20769</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325473.1">
        <property type="nucleotide sequence ID" value="XM_011327171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S2B9"/>
    <dbReference type="FunCoup" id="I1S2B9">
        <property type="interactions" value="854"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1S2B9"/>
    <dbReference type="EnsemblFungi" id="CEF88428">
        <property type="protein sequence ID" value="CEF88428"/>
        <property type="gene ID" value="FGRRES_10907"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10907"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20769"/>
    <dbReference type="eggNOG" id="KOG2957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051277_0_0_1"/>
    <dbReference type="InParanoid" id="I1S2B9"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000003">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF88428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="364" mass="40983" checksum="0C22CEF132C19620" modified="2012-06-13" version="1">MEGLYYNVNNGYVEGIVRGYRNSLLTGAAYNNLTQCETIDDLKLQLGPSYGDFLASLPPNPSTSALAAKTTDKLISEFRYVRAQAVGSLATFMDYVTYGYMIDNVALLITGTLHERDTRELLDRCHPLGWFETMPVLCVATNIEELYNSVLIETPLAQYFKGSLSHQDLDELNIEIVRNTLYKNYLEDFYNFVNTHPEMAGTPTAEVMSEILEFEADRRAINITLNSFGTDLSKQDRNKLYPSFGKLYPEGTLMLSRAEDPEGVRLAVDGVHDYKSFFDAINVGGGPSGPGNMGGGAGETKTLEDMFYQKEMEISKNAFTRQFTHGIVYAWVKLREQEIRNITWIAECIAQNQKERIGNYISVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1S2X9</accession>
    <accession>A0A098DXD3</accession>
    <name>I1S2X9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG11137.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T21303</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate lyase/PEP mutase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF85992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325214.1">
        <property type="nucleotide sequence ID" value="XM_011326912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S2X9"/>
    <dbReference type="STRING" id="229533.I1S2X9"/>
    <dbReference type="EnsemblFungi" id="CEF85992">
        <property type="protein sequence ID" value="CEF85992"/>
        <property type="gene ID" value="FGRRES_11137"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11137"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21303"/>
    <dbReference type="eggNOG" id="KOG1260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027389_3_0_1"/>
    <dbReference type="InParanoid" id="I1S2X9"/>
    <dbReference type="OrthoDB" id="1923844at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000009">
        <property type="entry name" value="2-methylisocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF15">
        <property type="entry name" value="PHOSPHONOMUTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G03820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00061405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF85992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="302" mass="32489" checksum="31207D399186F10F" modified="2012-06-13" version="1">MDDICHTITAGRLLRQRIKERDFMLAPGVYDGFSARIALEVGFNVLYMTGAGVTASVHGSADLGIATLNDMRRSAEMIANLSLSTPVIADADTGYGGPIMVARTVEQYSRSGVAALHIEDQVQTKRCGHLAGKRLVDLTEYLARIRAAVQARKRIGSDIVIIARTDAIQKHGYEEALKRLRAARDAGADVAFPEGLRSVDEARQIITDLAPWPVLLNMVENSVTPTLSAKEAKHLGFSIMIVPLATLAPAYTSIKTGLQKLKETGSANTELTPQALFRVCGLDVSLKIDEEAGASNFQGGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1S410</accession>
    <accession>A0A098DP87</accession>
    <name>I1S410_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG11562.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T15945</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323064.1">
        <property type="nucleotide sequence ID" value="XM_011324762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S410"/>
    <dbReference type="ESTHER" id="gibze-q4htz6">
        <property type="family name" value="Tannase"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF79771">
        <property type="protein sequence ID" value="CEF79771"/>
        <property type="gene ID" value="FGRRES_11562"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11562"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15945"/>
    <dbReference type="eggNOG" id="ENOG502SH94">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014819_3_2_1"/>
    <dbReference type="InParanoid" id="I1S410"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF13">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF79771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="519" mass="55831" checksum="244517DCA52DBB40" modified="2012-06-13" version="1">MTNNYTAGSLLCSAENLVSPDIFGTQILNISASMVTNFTTSVPGDFNFHHGPAEVEDVDFCNITVSYTHPGQDDMVTVEAWLPINWNGRLQAVGGGGLVAGRYALSDAQMSGAVGEGYATTTTDAGQQGKLATEWGSLSPGNVNLYLLQNMMTTSLNEQAIIGKSLVHSFYGRKPEFSYFSGCSQGGRQGLMLAQRYPDAYDGIASSAPAINWNQFINGIFWPQLIMNMMGEYPAPCELQEIAMAATAACDGQDGVLDGIVSDVRSCKFDPFNLVGTTFDCAGTQMEISEAAAAVSNATWAGPKSVEGNFLWYGIAPGANITAIDGVGQGPAITTCMGNGTCTGVPFSVYTDWASVFVERNLSMSFTTLTHDDYDRIFESSLLQYSHINGDDTNLAPFFQRGGKILGYHGTLDALIPLQGTLHYYDSISAVVPDIHDHYRMFEAPGVGHCYGGHGGQPQTTFDALRAWVENGTVPDTLPVSYTDKNGTLNSRFLCPYPKKVRYNGRGNTALETSYTCEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1S456</accession>
    <name>I1S456_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FGRAMPH1_01T11287</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323039.1">
        <property type="nucleotide sequence ID" value="XM_011324737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S456"/>
    <dbReference type="SMR" id="I1S456"/>
    <dbReference type="EnsemblFungi" id="CEF77446">
        <property type="protein sequence ID" value="CEF77446"/>
        <property type="gene ID" value="FGRRES_11617"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11617"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11287"/>
    <dbReference type="eggNOG" id="ENOG502QQ5E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024508_3_2_1"/>
    <dbReference type="InParanoid" id="I1S456"/>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF1">
        <property type="entry name" value="XANTHINE_URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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            <begin position="95"/>
            <end position="114"/>
        </location>
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            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF77446.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF77446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="584" mass="62533" checksum="318DB17F554870A3" modified="2012-06-13" version="1">MGWMENANHKIAASAVGRWFQLDGSGHPRERKGSLFFTEIRAGLATFFAMAYIIAVNSSIVSESGGTCVCPAYKDGACVPDDAYQLCVAEVKRDAVTATAAISALATFFMGLFANLPVGLAPGMGLNAYFTYTVVGPGGSGPVPYELALTAIFIEGFIFFGLALFGMRQWLARAIPRCIKLATSVGIGLFLTLIGLTYSEGIGLIVGSTSTPLELAGCEASYRDPATGLCPSSQKMRNPSMWIGIFCGGILTVLLMMYRVKGAVIAGILLVSIISWPRGTDVTYFPYDTLGDDRFDFFKKVVDFHQIKRTLNVLQFDISGHSGQFGLALITFLYVDILDCTGTLYGMARFADLVDPVTQDFEGSSIAYMVDALSISIGAVLGVPPVTAFVESGAGISEGGKTGITAMVAGICFFISIFFAPIFASIPPWATGCVLILVGSMMVGAVTEINWKYMGDAVPAFLTIAIMPFAYSIADGLIAGICTYMVLNTVVLLVKIISGGRIVPPNYEERDGWTWRIPGGFLPPWMNRLAHGKKDFWREDNPPHNTNNETVVSDTAAPKENGSDHGGSEGGKVAETTLPREKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1S472</accession>
    <name>I1S472_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T06677</name>
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    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_011320448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S472"/>
    <dbReference type="STRING" id="229533.I1S472"/>
    <dbReference type="EnsemblFungi" id="CEF75143">
        <property type="protein sequence ID" value="CEF75143"/>
        <property type="gene ID" value="FGRRES_11637"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11637"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06677"/>
    <dbReference type="eggNOG" id="KOG4635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028759_0_1_1"/>
    <dbReference type="InParanoid" id="I1S472"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF75143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="379" mass="42249" checksum="5A671D6ECEBA653B" modified="2012-06-13" version="1">MPTPSSNPPVEASSPRSYSFSTCPDDAQSQPHPAWQARDEGQARADDGGIQSGPGLSVDGASPLTVDAPTAPGCPNDDTTMYDGRPSNDLSSRSTTMSPRPQTATTAATTPMHEGSGPETKGRDAETGNQLSQEPPNNTQRASEPQSAPCESSRRRGSPNREWECVDFDAQEDELWSPSMGPDYSCIRTIPSAPSSYLRPGSKFHGTQQSERQVYDVQVEIKHVDMRESFLCGYLRIQGLTEDHPTLTTYFEGEIIGSKYSFYTQHENWGANSKVDLSHWAKFTAFRPFQKQARKGPVIIRDAAQRETIFMRWKEHFLVPDHRVRTISGASFEGFYYICFNQVKGEVSGIYFHSKSEKFQQLELKHVPDRGCFAATEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I1S4I1</accession>
    <accession>A0A098D2T6</accession>
    <name>I1S4I1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T00897</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315993.1">
        <property type="nucleotide sequence ID" value="XM_011317691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S4I1"/>
    <dbReference type="EnsemblFungi" id="CEF72251">
        <property type="protein sequence ID" value="CEF72251"/>
        <property type="gene ID" value="FGRRES_11748"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11748"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00897"/>
    <dbReference type="HOGENOM" id="CLU_3377202_0_0_1"/>
    <dbReference type="InParanoid" id="I1S4I1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF72251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="34" mass="3739" checksum="76241B5A3BB36BDC" modified="2012-06-13" version="1">MSISVGPCFDFGMKRLGLHNDAEHPQTSTGYSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1S4P7</accession>
    <name>I1S4P7_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Efflux pump dotC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dothistromin biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FGRAMPH1_01T01803</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Efflux pump; part of the gene cluster that mediates the biosynthesis of dothistromin (DOTH), a polyketide toxin very similar in structure to the aflatoxin precursor, versicolorin B. One function of dotC may be to transport early-stage dothistromin biosynthetic intermediates from the cytoplasm into vacuoles, thereby affecting the rate of dothistromin production.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316416.1">
        <property type="nucleotide sequence ID" value="XM_011318114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S4P7"/>
    <dbReference type="FunCoup" id="I1S4P7">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF72702">
        <property type="protein sequence ID" value="CEF72702"/>
        <property type="gene ID" value="FGRRES_11815"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11815"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01803"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="InParanoid" id="I1S4P7"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000014">
        <property type="entry name" value="MFS drug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="74"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="570"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CEF72702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="604" mass="64564" checksum="7AAD2C7732F224E6" modified="2012-06-13" version="1">MAVSAPTPEHRTSSDSTLDVERDGINAGSNNPTAAAEATQDGAATAPAGSSPLPGAPGAEDPEAGRTRSENILIISALCLALFLAALDTTIITTAVPTIANEFNSSQGYVWIGSAYLLGNASFVPTWGKISDIFGRKPVLLAAAVIFWIGSLLCAVSNSMGMLIAARAIQGIGGGGLIVLPNIAISDLFSIRNRGMYFGILGMVWALASAVGPILGGVFTSQVTWRWCFYINLPISAVAFVILVFFLKLHNPRTPMKEGLMALDWPGSILIIGGTVMWLLGLEFGGVSFPWNSATTICLLVFGILVIGLFLLYEWKVAKFPVLPLRLFSTRNSIASYGVGFTHAFVFMSGSYWLPLYYQGVLGASSLLSGVYLLPYVLSLSFISAGVGIYIKKTGQYKLAIVMGFFVTVIGFGLFIDLEPRANWVKIIIFQIVAGIGIGPNFQAPLIAIQTNVEPRDIGSATSCFSFIRQLGTSISVVVGGVIFNNEMEKQYPKLEEELGPSLASRLSGANAAGSVELVGSLTGEDGRVAKTAFWHSLRTMYIVYTCFAGLSLVISLMIKQVNLSKEHKEHKTGLKSLKRRDDENNEANEGEGVIPGNEKTADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1S4Q7</accession>
    <name>I1S4Q7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T01985</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316503.1">
        <property type="nucleotide sequence ID" value="XM_011318201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S4Q7"/>
    <dbReference type="STRING" id="229533.I1S4Q7"/>
    <dbReference type="EnsemblFungi" id="CEF72794">
        <property type="protein sequence ID" value="CEF72794"/>
        <property type="gene ID" value="FGRRES_11825"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11825"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01985"/>
    <dbReference type="eggNOG" id="ENOG502T0H9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041042_0_0_1"/>
    <dbReference type="InParanoid" id="I1S4Q7"/>
    <dbReference type="OrthoDB" id="4366798at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF72794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="399" mass="45522" checksum="E570E6FEF8848BD4" modified="2012-06-13" version="1">MDDPDVAWPAWKFGMKRDDLFTNLHQQYNTFTFNLQDPEAFHHDVYEISHDADTVDEFHRLMAERKQQRLCELHESLESLAVEIIANPKLMDSEHWQHALQLFRTKSFDSIVRYFASYLPANYVDRNERDHDTISIASSSYSEANSVKTDSTTASSVDGVSSFFDDEPVMKKKSPLSIHTDMRSSSIVQAPPSPPHSVVAHSDESSASSPMESHRYSSNPPSRSMSFSGSVSRPFLPDLPRLLVHDDDETSQSDDNDEAVISDLDCAESQSSLDTMDEGEQPQEYEDDLEDEDEFPTAQFPEDASDAFDFCNDTPESNDTPTPRQETTASCYVEYKSVAAWRIPSPRRSTSPSPKSHTYRRESSVLMDIRRSPEESLSKIQKTMHDSQRKRPVIWRRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1S525</accession>
    <accession>A0A098D3L7</accession>
    <name>I1S525_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T03445</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
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    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
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    <dbReference type="EnsemblFungi" id="CEF73528">
        <property type="protein sequence ID" value="CEF73528"/>
        <property type="gene ID" value="FGRRES_11943"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11943"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03445"/>
    <dbReference type="eggNOG" id="ENOG502R8S9">
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        <property type="component" value="Chromosome 1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF73528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="252" mass="27933" checksum="8F415611DB081D64" modified="2012-06-13" version="1">MVPVVTKIAHNVRYQHLKVLRNLGEFKSIRFEQSPTSYRSVLHSEIPYITMTSSIATAGASSAIASLAIKSDFATVARKNGVDETSIGDYELVVKEYIHPPQNSPIRILEVGMGCRQTPAIKNLYRTWQEYLPTSCELFSIESNSACTDLGAAQLEGKFDIIIDSGFHTLEYQIQALKAFWKHVSPGGVYVLMSTTPPTSKDLHTLLTNVASTPPKESISSELKSIHCGERVCVLMKDLSEDEFSYLGLGWE</sequence>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1S575</accession>
    <accession>A0A098D7F6</accession>
    <name>I1S575_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T04147</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317535.1">
        <property type="nucleotide sequence ID" value="XM_011319233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S575"/>
    <dbReference type="STRING" id="229533.I1S575"/>
    <dbReference type="EnsemblFungi" id="CEF73881">
        <property type="protein sequence ID" value="CEF73881"/>
        <property type="gene ID" value="FGRRES_11993"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11993"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04147"/>
    <dbReference type="eggNOG" id="ENOG502RA0Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057185_0_0_1"/>
    <dbReference type="InParanoid" id="I1S575"/>
    <dbReference type="OrthoDB" id="3526284at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF73881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="265" mass="30246" checksum="9DC72C4D96CC9E93" modified="2012-06-13" version="1">MSQKDTFDDGELPPPYTESGPSSAPTPTYEPRQSVTTIFSSHLQNLPLRIHSVQAARTSARDQRDSEILTLLVPHVEEMLSSITAKDPPPRLTETIFVPGDAVGEEWFFSDEDESRTVVRVREDTKLVGDQKRPPKPEVEPRKEKAFDEWGRWQDDNTQDSFSDNVLWWSDHDMAIRLAKYISPERVDRQVVKAHVEQAKKSSGWGFLKKSKPQTPEPPKPKVQEEDPVTMVVKAEEVTFRKENAMGIWEGKTGWGLVIKVKIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I1S5G6</accession>
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            <fullName evidence="1">Chromosome 1, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_011319781.1"/>
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    <dbReference type="AlphaFoldDB" id="I1S5G6"/>
    <dbReference type="EnsemblFungi" id="CEF74449">
        <property type="protein sequence ID" value="CEF74449"/>
        <property type="gene ID" value="FGRRES_12084"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12084"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05289"/>
    <dbReference type="HOGENOM" id="CLU_2184213_0_0_1"/>
    <dbReference type="InParanoid" id="I1S5G6"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF74449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="109" mass="12165" checksum="5F17717A2B00B8B5" modified="2012-06-13" version="1">MVISALILQKYLKQRMTPGESLTVVTISEPSTGAKLKTMCRFHVLGSLSKDDGASHAYVAKIFYQSLKQNESGQTTDWMVAKALHDAIESDRDLAKDPRWWAPYIHSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I1S646</accession>
    <accession>A0A098DJ61</accession>
    <name>I1S646_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T14391</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321577.1">
        <property type="nucleotide sequence ID" value="XM_011323275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S646"/>
    <dbReference type="EnsemblFungi" id="CEF78998">
        <property type="protein sequence ID" value="CEF78998"/>
        <property type="gene ID" value="FGRRES_12317"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12317"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14391"/>
    <dbReference type="HOGENOM" id="CLU_2109269_0_0_1"/>
    <dbReference type="InParanoid" id="I1S646"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF78998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="115" mass="12837" checksum="D2F6C14E19D40C0B" modified="2012-06-13" version="1">MIHVHPCFCHHQAMDVDGSNIDSGNKPTIKTTYRMLKHLHDCRPPLNLTSFSAKTVAPDPFSTPLSVAPPLTQGSRERDEQLVQDLPTITGATTTVTCEQNRSNNRRRLPLSFDL</sequence>
</entry>
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    <accession>I1S749</accession>
    <name>I1S749_GIBZE</name>
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        <submittedName>
            <fullName evidence="5">Chromosome 3, complete genome</fullName>
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    <gene>
        <name evidence="6" type="primary">FG05051.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T16971</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323535.1">
        <property type="nucleotide sequence ID" value="XM_011325233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S749"/>
    <dbReference type="SMR" id="I1S749"/>
    <dbReference type="STRING" id="229533.I1S749"/>
    <dbReference type="EnsemblFungi" id="CEF88587">
        <property type="protein sequence ID" value="CEF88587"/>
        <property type="gene ID" value="FGRRES_12672"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12672"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16971"/>
    <dbReference type="eggNOG" id="ENOG502RQJN">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_018825_2_0_1"/>
    <dbReference type="InParanoid" id="I1S749"/>
    <dbReference type="OrthoDB" id="2594507at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
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    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Phosphohistidine domain"/>
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        <property type="entry name" value="PMDh-L-like_dom"/>
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        <property type="entry name" value="PMDh-S-like_dom"/>
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    <dbReference type="PANTHER" id="PTHR36577:SF3">
        <property type="entry name" value="DUF521 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00490)"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF04412">
        <property type="entry name" value="AcnX"/>
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        <property type="entry name" value="AcnX_swivel_put"/>
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        <property type="entry name" value="UCP036630"/>
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    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphomevalonate dehydratase small subunit-like" evidence="3">
        <location>
            <begin position="30"/>
            <end position="114"/>
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    </feature>
    <feature type="domain" description="Phosphomevalonate dehydratase large subunit-like" evidence="4">
        <location>
            <begin position="171"/>
            <end position="575"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF88587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="598" mass="64815" checksum="F86743CEA4ED1F40" modified="2012-06-13" version="1">MGSLQETTWTGTAYVQGRASAKLLASNLELSFWGGVDPQTSEVIDRHHTLSGKHLQNTILAIPGGRGSCTGSGIMLELLLNGKAPEAIIFERREDILTLGVMIAEEVFQQSIPVLVLKKEDFRQLLKLDGQIIYVDYGHISTAPILSKHTDSARDPESGLILETAPAREGIKLSTLDQELFRGDYGEASRVAFRIVLRMAHLLGATRLMDITQVHVDGCVYTGPATLALAERLRDWGGKVRVPTTLNSISVDQKRWRALGVDTAFGEAADALGKAYVDMGAKPTYTCAPYQLESAPKLGEQVAWAESNAVVYSNSVLGARTMKYPDFLDISIALTGRAPKGGPHIYANRLASVRVNVSGIENITDLDDSFPPLLGYYVGTLSTSRIPVLTGLESYGLSTDDLKAFGAAFATVSSAPMFHIVGVTPEATTLEAVVASELTTFEVKPSDLVNSWDKLNSAPINQPLDLVSLGNPHFSLPEMRKLAELCQGRRKAANVAVVVTCGRSIYKLAEQAGYISKLEEFGVQVLTDTCWCMITEPVIPRTAKTIMTNSSKYAHYGPGLTGKVMYFGSLAACVEAACQGRYDAGRPRWLQPEPDTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1S755</accession>
    <name>I1S755_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG05069.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T17019</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323558.1">
        <property type="nucleotide sequence ID" value="XM_011325256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S755"/>
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        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1S755"/>
    <dbReference type="ESTHER" id="gibze-q4ici9">
        <property type="family name" value="Duf_676"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF87251">
        <property type="protein sequence ID" value="CEF87251"/>
        <property type="gene ID" value="FGRRES_12678"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12678"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17019"/>
    <dbReference type="eggNOG" id="KOG4372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007367_0_0_1"/>
    <dbReference type="InParanoid" id="I1S755"/>
    <dbReference type="OrthoDB" id="5368485at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016445">
        <property type="entry name" value="Rog1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF676"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005412">
        <property type="entry name" value="UCP005412_abhydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <begin position="267"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="344"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="436"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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    <feature type="region of interest" description="Disordered" evidence="3">
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    <feature type="region of interest" description="Disordered" evidence="3">
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    <feature type="compositionally biased region" description="Basic residues" evidence="3">
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1084"/>
            <end position="1099"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF87251.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87251"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1099" mass="120637" checksum="50F28027E3CC0A6D" modified="2012-06-13" version="1">MLLLHQVGSLKTGEVVRYTVTYTPSQDRILPSPEKLFLRVRNTSAIALRAAFVHGPYTLCAAAYPAGFNPNEKFEYPERYGVPEFEPMVKAGGSWECELVVPVTIRQSAGLGSHGGFGKGPSHDHESASWIVEVSSQILFSTSAAVGFEVVLARDKKSLGLTNASQVINGQTQVSQPGKISDHQQGVGAKDGHHPAQPKGVFSRAIHVKVEDTAALWNTPRLPGWDDKGDPEKRNGPDQHVESVSETNDPEVEKNDDSKPQEPKQKKKKVHVVILTHGLHSNLGADMLFMKESIDAAVKQAKIDAKARRARERAEREQSENGLAKSDAYNTKDQDKVEGEDDESDDDEEVIVRGYSGNSTKTERGIKYLGKRLARYVLSMTYPDQPFLPTGKGMAEAVSHTFDKHDSQQKAVHAHSSIHLGKDGARLRKAERPYKITSMSFIAHSLGGLVQTYAIAYIQKHSPQFFDLIKPINFVALATPFLGLSNENPLYVKFALDSGLVGRTGKDLGLTWRAPTIARSGWGAIVGNLGETAHKKVYGDSQPESKPLLRILPTGPAHTALKKFRNRTVYSNVVNDGIVPLRTSCLLFLDWQGLGRVEKARRDAGLVETVVGFGWAELTGSNQGNSRQRQLMNGERSVGQSGTSSPQNVHENMREVPQPPSTVMMDDDRTSLRSVATPYGDEVPSDSADSTNSGPLAGFFNLFKSNEPPKPQNVSQKQKRIFSNSQTLKEATDGPGEDSAESASAKQSTVTTGHEGEDEMTAPPRTTVFESASDLLNPKMPDVDYLVDPSKRPRTIFHDRVYHPADIPGPPLKKRPTTLVRRKTGQRQNSIGQASTSSAGSNPYPSINHEDSSLSTQDYDDTAHTNPDKDNNEVIDTANMRVEEKIARAYHKDLSWRKVLVKVEPDAHNNVLVRRMFANAYGWPVVKHLVDAHFSDSATARLRNEDEDNRERARNMNEPPDAHGAELKKSRDDLAGMTRTDSESREALDKVSDLPKAAPSKRDSDASMDQRPKAERADSVSWSDRDWHDSDNDSDLDFGGEGPGPTSPSALGQQNKGKEAQGSSAGWNWTEKIVGKGAARTKSPAHEGGEELKRNKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I1S7W7</accession>
    <accession>A0A098DQ40</accession>
    <name>I1S7W7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T22619</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326188.1">
        <property type="nucleotide sequence ID" value="XM_011327886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S7W7"/>
    <dbReference type="EnsemblFungi" id="CEF83472">
        <property type="protein sequence ID" value="CEF83472"/>
        <property type="gene ID" value="FGRRES_12942"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12942"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22619"/>
    <dbReference type="HOGENOM" id="CLU_2277776_0_0_1"/>
    <dbReference type="InParanoid" id="I1S7W7"/>
    <dbReference type="OrthoDB" id="10315682at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF83472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="102" mass="11800" checksum="74E9C56FF30A3FAD" modified="2012-06-13" version="1">MTNKLNAGNKTTHDSNSAKLETITQPRFLFFHYAHPNLPHDRQERMTLDPGTGPLSLFTATYHYQDLVEYKNKNKKLIDTKWESTYAQTPVLYAAEPRINGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I1S9V5</accession>
    <name>I1S9V5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T26365</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327947.1">
        <property type="nucleotide sequence ID" value="XM_011329645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S9V5"/>
    <dbReference type="EnsemblFungi" id="CEF83220">
        <property type="protein sequence ID" value="CEF83220"/>
        <property type="gene ID" value="FGRRES_13636"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13636"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26365"/>
    <dbReference type="HOGENOM" id="CLU_1562996_0_0_1"/>
    <dbReference type="InParanoid" id="I1S9V5"/>
    <dbReference type="OrthoDB" id="10392269at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF83220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="171" mass="18582" checksum="0E7BD654B7D3F429" modified="2012-06-13" version="1">MSERKSKWTYCDLKARAVSKSTEDRGARGRRASTCFAGASWLECGTTDRMQAGPMASNWYKGGVDGHEPLLGDCAAHVLEAGRVVLTDSSTTKDGGVSSNQFGWKSSAKKRLTTKGQTNEEQGRSIMERAPAVGNKALKRLTREAQEALLLLYSLLQRLFTAFLVTASVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1SAW8</accession>
    <accession>A0A098E0W4</accession>
    <name>I1SAW8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T21629</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325990.1">
        <property type="nucleotide sequence ID" value="XM_011327688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1SAW8"/>
    <dbReference type="EnsemblFungi" id="CEF87756">
        <property type="protein sequence ID" value="CEF87756"/>
        <property type="gene ID" value="FGRRES_13999"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13999"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21629"/>
    <dbReference type="eggNOG" id="ENOG502SS3X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_7_4_1"/>
    <dbReference type="InParanoid" id="I1SAW8"/>
    <dbReference type="OrthoDB" id="3477286at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF77">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="68"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF87756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="672" mass="76614" checksum="1D6BC375DDC5710C" modified="2012-06-13" version="1">MSAVDDEKLTTITSNLDTHEVIYTPLNGTRHEIRLLTLHPAAEEHNQICCTLSHAELKPSKSSDFPAYEALSYVWGKPNFSELILLNDQDFFITPCLKYALSCLRYKTQPRVLWVDALCINQSDILERNHQVSLMREIYSKCQRDIAWLDPVVGVAFKSDDIYNDPKLAQMETSIRKGMELMHTIVEKDHNTLGQLFCAYHDGGYILEYNEEICLRDLFDMPFLWKRLWVMQELSLAPNLVMMCKGAELGWDSMSALLKDQPYMDAFHMMDSHAYNLPNWSDMFDRIKLIEDQRRLFSKPGLVDSKLMDVLTRFREVESTDPRDRIYGLLGLVTDDHGIHADYTKSVQDLYRETTISLINMSGNLDILCQNPFENSAGHKALQQLEDAMPSWVTEFNSRHGDCAEFIFAQRDIFNAGFKTCETPCRLLGTRSDILIVRGVILGAVGPILQVKCQDYSARDMLKLYFSEEAILKPKSLTYAPTFGAKKLTSGETCSRAFWRTLAKDCTLPPRMRRLRSKEVRSLDKVNMEKLSDETMITVNTICVEYDLYRDRSLFSKCLGNVLDYSGIESKFSTLSVGNPYGHYATKDHMFVVTKNGLYVLARPYVEEGDVVAVLDGGKVPMILRKTDPVSEKSTEDTYRIVGPAYVHGFMDGKAEVGVTEGWLAKQDILLV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-25" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q4I0J6</accession>
    <accession>A0A0E0SBB5</accession>
    <accession>V6RV41</accession>
    <name>NDC80_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName>Probable kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">NDC80</name>
        <name type="ORF">FGRRES_09262</name>
        <name type="ORF">FGSG_09262</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
        <text evidence="1">Associated with kinetochores.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS231668">
        <property type="protein sequence ID" value="ESU15810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328506.1">
        <property type="nucleotide sequence ID" value="XM_011330204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4I0J6"/>
    <dbReference type="SMR" id="Q4I0J6"/>
    <dbReference type="FunCoup" id="Q4I0J6">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="STRING" id="229533.Q4I0J6"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T27527">
        <property type="protein sequence ID" value="FGRAMPH1_01T27527-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G27527"/>
    </dbReference>
    <dbReference type="GeneID" id="23556224"/>
    <dbReference type="KEGG" id="fgr:FGSG_09262"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27527"/>
    <dbReference type="eggNOG" id="KOG0995">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012583_0_0_1"/>
    <dbReference type="InParanoid" id="Q4I0J6"/>
    <dbReference type="OrthoDB" id="7459479at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.30:FF:000001">
        <property type="entry name" value="Probable kinetochore protein ndc80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057091">
        <property type="entry name" value="NDC80_loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24487">
        <property type="entry name" value="NDC80_loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0137">Centromere</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0995">Kinetochore</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000246640" description="Probable kinetochore protein NDC80">
        <location>
            <begin position="1"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="323"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="587"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="726" mass="82885" checksum="9E8714B589B1E3DF" modified="2005-08-16" version="1">MSQDTGLWSVRRPRETLGGISANSAIPQPGSTMKRSSSNIGGNYPGSHVRSMSGSRHSLAMPRPSQPMFQRSSSGTNLVDLGLSSVKRSSFAPKSTFTPGTATKRASTDGDRRSSVYRPRQSTVPAVSHHQSFFQTTPAPAGVPRDPRPLKDRSFQARIGQEIMEYMVQHNFEMEMKHVLSQNVLKSPTQKDFNYMFQWLYHRIDPSHKFQKNIDQEVPPLLKQMRYPFERSITKSQIAAVGGQNWSTFLGLLHWMMQLAQMLDGYVNCQYDEACMEAGIDVSGDRIIFDFLSNGYRDWLAMDEDLGDEEAERVLAPHVQSMAAAFERSNSKYTSELDMLEAENARLLKEIEDLEKSTPDPAVLDHHFKIMEEDKVKFEEYNALAMQRSEKYESRSQVLQEELDKLLEELQEADEERRSLQKAVDAQGISMQDIDRMTAERERLQRGIESASQRLEEVKKKVSEREAEASRKLDELEQMVDRYNTMAYQIALIPSTAANAKGREFELQVTVADDSDFTTSIMKSGPSSADRLVVDSTTGHQAGHILNLDLRGKIRNSFISLRKEISDRRATAMDEMIKDHDLLDGIKEAIEDRRGEVEALNHRVRAAEEEYEKTKEVTTAQKLASDAHIEKMEKELSRMRAGLSENVQILEQREINTTIEYEQLVLQANALREELHTEIDRMLNDVIKFKIHVQKSLDDYEGFVTEELEKELGSDEMQEDTQRMDM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-25" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q4IB63</accession>
    <accession>A0A0E0SP93</accession>
    <accession>V6RBZ8</accession>
    <name>GPI10_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName>GPI mannosyltransferase 3</fullName>
            <ecNumber>2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>GPI mannosyltransferase III</fullName>
            <shortName>GPI-MT-III</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Glycosylphosphatidylinositol-anchor biosynthesis protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">GPI10</name>
        <name type="ORF">FGRRES_05545</name>
        <name type="ORF">FGSG_05545</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.</text>
    </comment>
    <comment type="pathway">
        <text>Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 22 family. PIGB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-"/>
    <dbReference type="EMBL" id="DS231665">
        <property type="protein sequence ID" value="ESU11517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324093.1">
        <property type="nucleotide sequence ID" value="XM_011325791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4IB63"/>
    <dbReference type="FunCoup" id="Q4IB63">
        <property type="interactions" value="879"/>
    </dbReference>
    <dbReference type="STRING" id="229533.Q4IB63"/>
    <dbReference type="GlyCosmos" id="Q4IB63">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T18171">
        <property type="protein sequence ID" value="FGRAMPH1_01T18171-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G18171"/>
    </dbReference>
    <dbReference type="GeneID" id="23552724"/>
    <dbReference type="KEGG" id="fgr:FGSG_05545"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18171"/>
    <dbReference type="eggNOG" id="KOG1771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012353_1_1_1"/>
    <dbReference type="InParanoid" id="Q4IB63"/>
    <dbReference type="OrthoDB" id="416834at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000246264" description="GPI mannosyltransferase 3">
        <location>
            <begin position="1"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="613" mass="69884" checksum="14980A1D26D44896" modified="2005-08-16" version="1">MSSATVSRKSLDEARNQRNRSFFLRDIIVIRLINAWWIATFFQPDEFFQSLEPAWNLAFGSQSGAWLTWEWQHQLRTSLHPALFAGVYLVADFISSHILPVGILRATILVAVPQALQAVIAGLGDWYTWQLAVSIYGANSNVSFFALFLQIFNPWQWYCSTRTFSNSLEMTLTVMAMYYWPWELLGVAQTTKENPKPAPILKSLWSLRASLCLAALAVVLRPTNILIWATIVLFTITRISLQGPSPLTLSTVVTLIREAIWCGSLILAISAASDRWYFGFWTFPAYNFLYFNLSKSLAVFYGRSPWHYYFLQGLPLICTTSLPFAVASLYKPTAHATSTQQFNVLKTLAYTVFTTVGALSLITHKEVRFIYPLLPALSILAAPYTASFFTSQPSPTTNNPRPQPQIRNKRYLFVALGVNMFLAGYLSFFHQPAPLNVLAYLRHEYERIHPDSVQLAQTSHFSAMPENEDELFALFLMPCHSTPWRSHLIYPGLRAYALGCEPPLHTEPNTPERDNYRDEADRFYDDPIPFLTSELFSPTKALTVPRYIVGFESIEPWLQEFVQTFEAQSLGLTQVRPVWKGFNGLFNEDWRRSGDMIVWDTGVYDNAPPTKEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q4IK03</accession>
    <accession>A0A0E0RU24</accession>
    <accession>I1RFI0</accession>
    <accession>V6R1U2</accession>
    <name>MIA40_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial intermembrane space import and assembly protein 40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mitochondrial import inner membrane translocase TIM40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MIA40</name>
        <name type="synonym">TIM40</name>
        <name type="ORF">FGRRES_02455</name>
        <name type="ORF">FGSG_02455</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Cu(2+) or Zn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The CHCH domain contains a conserved twin Cys-X(9)-Cys motif which is required for import and stability of MIA40 in mitochondria.</text>
    </comment>
    <dbReference type="EMBL" id="DS231663">
        <property type="protein sequence ID" value="ESU07892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318377.1">
        <property type="nucleotide sequence ID" value="XM_011320075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4IK03"/>
    <dbReference type="SMR" id="Q4IK03"/>
    <dbReference type="STRING" id="229533.Q4IK03"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T05889">
        <property type="protein sequence ID" value="FGRAMPH1_01T05889-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G05889"/>
    </dbReference>
    <dbReference type="GeneID" id="23549830"/>
    <dbReference type="KEGG" id="fgr:FGSG_02455"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05889"/>
    <dbReference type="eggNOG" id="KOG4149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054990_0_1_1"/>
    <dbReference type="InParanoid" id="Q4IK03"/>
    <dbReference type="OrthoDB" id="7481291at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2900:FF:000002">
        <property type="entry name" value="Mitochondrial intermembrane space import and assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-0676">Redox-active center</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000235290" description="Mitochondrial intermembrane space import and assembly protein 40">
        <location>
            <begin position="30"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="2">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Signal-anchor for type II membrane protein" evidence="2">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="2">
        <location>
            <begin position="66"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="CHCH" evidence="3">
        <location>
            <begin position="160"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="95"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="208"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx9C motif 1" evidence="3">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx9C motif 2" evidence="3">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="1">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="163"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="368" mass="39753" checksum="D7DCF3B54C5A4E51" modified="2012-10-31" version="2" precursor="true">MYRNTMRSASRPVIASLRSSTIRAAPRRFASTAPADKPRSFKGSLVRLGLAFGAVYYYNTSPIFADEAISKTVPAPAAFSDDDLPTVDSIVEEKRKQIKAKSEETAASSKTPESQQSNPQTAAADGSPAALEEEAGQQGAFNPETGEINWDCPCLGGMADGPCGEEFKTAFSCFVFSQEEPKGMDCIDKFQGMQECFKKYPDIYGAELADDEDGAPTPDFGDEQPSGEPTTAEVKSNGELARETKDKTAADATKFDDSQKPAESKTPAKTTSTSTDSAQKPAVDAHRDAEPKSDAETASSGSRMVQDVAIPIEKPVNDKYWQDMHKSEVQKKEVTVGITQAHDATAANEEIKHIERQEAAKKNAEKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>V6RGM9</accession>
    <name>V6RGM9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG07189.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T24185</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326911.1">
        <property type="nucleotide sequence ID" value="XM_011328609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6RGM9"/>
    <dbReference type="FunCoup" id="V6RGM9">
        <property type="interactions" value="645"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF83531">
        <property type="protein sequence ID" value="CEF83531"/>
        <property type="gene ID" value="FGRRES_07189"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07189"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24185"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006909_5_0_1"/>
    <dbReference type="InParanoid" id="V6RGM9"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000138">
        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF83531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="470" mass="53181" checksum="14AD4FA732199481" modified="2014-02-19" version="1">MGSLTQSSSFDVNKVAIIGAGPTGIAAAKYLIAQGIRDITIFEQQDHVGGIWHYHGFAAGTCPVPQEDPYHPPDEPLKWDSTSPPIFTSPMYENLHANIPKEVMNFSDQPFPEDAKLFPERPMIEDYLIKYSEDIKPLIQFCQRVERVSLKQQDGRDKWEVEAKSTMTGNDGITQAFDAVVVGNGHYSTPFVPDMRNIKEFNEAYPGVITHSKQYRTPCTFKDRKVVVVGNGPSGLDIALQINQECRKPAFLSVRHPTPPDRLHHCGCEEMAEIDEFMVEQKGLRFKDGRVETDIDAVIFCTGFLYSYPFLQDLDHKLVTTGRGVRGLYQHVFDIRHPTLVFPGLNMKAAPWPLAESQAALFAAVWSNNLELPSRGVMEAWNMELEKREGEALHMFGPNGDGLYINELHDWVMTAKRPGKEPPHWDRELMWQRSVFIDAKVKFEQLGCKARTMKEVGFCYEPDNTQTSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D0Q4</accession>
    <accession>A0A0E0RL97</accession>
    <name>A0A098D0Q4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG00162.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T00443</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D0Q4"/>
    <dbReference type="EnsemblFungi" id="CEF72022">
        <property type="protein sequence ID" value="CEF72022"/>
        <property type="gene ID" value="FGRRES_00162"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00443"/>
    <dbReference type="eggNOG" id="ENOG502R4JR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098D0Q4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000011">
        <property type="entry name" value="Taurine catabolism dioxygenase TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="3">
        <location>
            <begin position="112"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF72022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="428" mass="48307" checksum="AB3E6E8A373A81BE" modified="2015-01-07" version="1">MATAAILTPVAPPSAPTFGTTPAAQPPPGQPDISYHPNWETYQARVARRTQTENLSKEIPEGFPKELKGDLVWEGETVAKEYKWTYTFTDEQLEDINNALAHFKSLNIAKGYISQETFPLPKTHDELRRLSRELHFGHGFFVLRGLDVDRYTREENIIIYAGISSHIGSIRGRQDAYYDGKRADVVLGHVKDVRSTTKIKIGSPAYTADKQVFHTDSGDIVSLFALGTAAEGGASRLASAWRVYNHIAETRPDLIRTLAEDWEAELFTKTVNDTDKVSRRPLIHHQPASTDGKTPERVVLQYARRYYVGFGALPRGNHIPPITEAQAEALDTLHFLGERFSVSTDFQKGDIQYVNNVAVFHARDGFRDTEDQQRHLLRLWLRDPEYAWETPAALSERWERVYGGVTPELQTFPLEPYVRSESAGVVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D5L9</accession>
    <accession>A0A0E0RPR1</accession>
    <name>A0A098D5L9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG01156.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T02869</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D5L9"/>
    <dbReference type="STRING" id="229533.A0A098D5L9"/>
    <dbReference type="EnsemblFungi" id="CEF73236">
        <property type="protein sequence ID" value="CEF73236"/>
        <property type="gene ID" value="FGRRES_01156_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02869"/>
    <dbReference type="eggNOG" id="KOG4521">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A098D5L9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056548">
        <property type="entry name" value="HEAT_Nup120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048884">
        <property type="entry name" value="Nup120_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NUP120_helical"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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        <location>
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        <location>
            <begin position="613"/>
            <end position="745"/>
        </location>
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            <begin position="833"/>
            <end position="1000"/>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF21486"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23300"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1162" mass="130669" checksum="C571194B2C43C0C0" modified="2015-01-07" version="1">MDSGDTQYVFKETRVNLDPPTTSSVVTIRVPSNSIHGRSHRKAAGENSSEDETSFRVKNLASSSSIYYRIWHDTPRSFLWRILEDGTLLSIRAVDVCKKSQAADFPLFLNFHFSVPIQPGCVAFSDHEEHDSLCVFVLDQAYQLYSFHLRPDLFRKRSAIDAGISDLGKVQAPAGLGFKHPHRMIAVNAETLLVTVNDGGMIRLDKTKTNDLSSNVWKESFFNVQGWAQNLRSLLPFQGKHTIKHGKINMEYSSATSIQVTSLGLDDGLFAITICLDHRMRIWNIDDGQILYTSDILNAERNPQEIGKWAIDPSQTNLVQIVGRNRGSRVCATFSPIGAGEFKFWKITAKDAFSVIVEDIFPNNSLVPVTPSSSDVWTLADFVLSCPAESAIQLWTLWKNNMTYRVQKLEVDRKNISQSWEDNWDGVYADNLIQAAEGSGPSDPTDVTEKWLQLILKPGQFTKSTLEAALSIYERGFGKSKDAGKGRGLAEAICSILGSTATLDRGSSGTMEYETFRASSEAQWLRFYRLLLELDKQRGEALGLTLDPHTGLAWVVCADFLSAIRECSSLERLYYNISSPEQDQLAQAALIGSGLTFVEGFPEYLTQSCQATLRPELFEDSSKTDLERIQYFSDKSGFWRGITDEDCNQVVDVLGQNFSTVTDDLYIDVMNLISAPEEAKTRNLRHPLTDFGKKLVVKAVQDNIELQWRVYFSQLILLVHMEFEFDNEADILHNRVDVGNVFRQLIAALRRLELLKWLAQTEITLPSVREKSENGSVSRKIVEDAQCVTALEANVGHLLGFSKKGTPLATDITDLVTNLCAPDSDIEVSPSLIQCFLIKRERADLALDIAPFCDQNPFSTYVQGRLQLALKDFNTAAIYFRKAAIGMSTENLESDRHSSGLLDDTEWNLLNHGPAKYYSHVVALFEKQKAYSYVIEFARLAMQFLGNKQDAMFTKTDMQSRLFNAAVATSQFELAHTTLVSIKDQAMKISNLRKLVDRMCATYHNIELVSMPFPGLQQEVDDILSQKTKATLDIIEDFPYHQVLYSWRIKHNNYRGAASVVLDRIHKLRSAGEGDEATGEDILDTPVTRQYLLLINALSCVDSKQAWIYDEAPAGYGQKDVVKRKVVSLADIRKQYQDELDRITAIHNNQFGFEADDVMEIS</sequence>
</entry>
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    <accession>A0A098D5M7</accession>
    <accession>A0A0E0RSM3</accession>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblFungi" id="CEF74248">
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        <property type="gene ID" value="FGRRES_15059"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04883"/>
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        <property type="component" value="Chromosome 1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="25"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF74248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74248"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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    </evidence>
    <sequence length="80" mass="9356" checksum="80BD2035A390C481" modified="2015-01-07" version="1">MVPRQGETSFHAFFLRRSKDTPFTRFQSAVEKRKKRRRQEERAATAYAGVKKKTRAKKPKPEPEPTGLEEIMNKINPPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D8X9</accession>
    <accession>A0A0E0RUH7</accession>
    <name>A0A098D8X9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T06195</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D8X9"/>
    <dbReference type="STRING" id="229533.A0A098D8X9"/>
    <dbReference type="EnsemblFungi" id="CEF74902">
        <property type="protein sequence ID" value="CEF74902"/>
        <property type="gene ID" value="FGRRES_20077"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06195"/>
    <dbReference type="InParanoid" id="A0A098D8X9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF74902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="475" mass="54329" checksum="BE669559873933CD" modified="2015-01-07" version="1">MLVRPTTFILYHLASQLYTFIMSWTQRSNPYDAFAQEATQTPLAVAFPQWMLNIWEITHDHPEGRWYIEPNARCLRQKASLRIVFAPLDLPRRDALSQCIELFNILNIPSDFTKERLQSVSHSFGRATDSHGSSSWFHFLCKNIDVKQRPGSAPEVDNRAAAMGYHISTLPQADYSWHRAGFFLRVENTGSTTLVCFGATPRVRQRINEFVAAKAWQHVSTDPYILFDLVFDALYFEVDDTVWKMNTIFGPLEHLILEYSNSKNVRKMSSKVPFSAMHNCAKHIIHIGEAIESCIMLVDATLHNIGNHNHTEQPTSREPVLKQLRETLQYRRSLFMSSQLRLSSLQKRIDNAITLSFNLVTQQDSMVMIQDSNSMKVIAAITMIFLPTTGVATVIGSQLFSSEIHKDGESWDIRLTPLFWTMWWIAIPLTVFVVLLAVIWHWWVHTESPTGEVVQVVKRAATFSSSGTRTPPTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DBF8</accession>
    <accession>A0A0E0RYD3</accession>
    <name>A0A098DBF8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG08013.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T08911</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DBF8"/>
    <dbReference type="STRING" id="229533.A0A098DBF8"/>
    <dbReference type="EnsemblFungi" id="CEF76258">
        <property type="protein sequence ID" value="CEF76258"/>
        <property type="gene ID" value="FGRRES_17115"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08911"/>
    <dbReference type="eggNOG" id="KOG1216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DBF8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010018638" evidence="2">
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            <end position="1059"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="245"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        <location>
            <begin position="1050"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF76258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1059" mass="113560" checksum="B51623DA3F8AF410" modified="2015-01-07" version="1">MRGFLFLGVAFLGVANASVVDFSRHQPRDVKALPRAYNDPVFHEARSFAERSDQPSKPQAATSAGDGEEDDQDTSQSSGSGSGSGSGSGSSSNGGSSNKNNAAVAQPQSDTSQSQGGGSGQSSNNDASNQPDTSGSQSQGGGSGRTKSNSAAARPESDTSGSGDGTSGNANKNSGSSAQPSSEDSSSGDGSSGNANQGNGQSNSGSRHGSDASNQDDNASDNTNQEPVVSSPSRGKNSGNQQDTVQAAAPTDDSDSEAPARFVAPKQNWRTTQQNQYPPYQPTQVWPTSKPTHVWPTSKPTQIWPTSQPTQVWPTSQPTYPTVPTSMPTQPTSMPTLPTSRPTQPTSMPTQPTSMPTLPTSRPTQPTSMPTLPTSMPTQPTSIPTLPTSRPTQPTSMPTLPTSMSTQPTSMPTLPTSMPTQPTSIPTLPTSRPTQPTSMPTLPTSMPTQPTSMPTLPTSMPTQPTSRPTQPTSMSTLPTSMPTQPTSMPTQPTSMPTLPTSMPTSSKPTTMSTQPTSMPTQPTSMPTQPTSVPTSSRTTSMPTQPTSMPTLPTSVPTSSKPTSMTTRSVPTTTKSLPSSMPTMPITTKPTKTTTVTRSRVTTEYITSTVYTTTVRTVTECGPYVTKCPHPPYVTTETIIDYTTVCPITETIYPPPMTTEYTTSTVYTTSIYTITECAPWVHNCGYIPYETTEIIPIYTTVCPIDYEPTPEPQWTTSTVYTTYYRTVTECEPYCPETPYVTWETVPIYTTVCPVDEVAPAPTAPPHHYEPEECMTEELSTSWSASTVYSTEVKTKDDCAWDDSWCDYGYPYVTTETVVLSTTLFPEVITEWVPCPTYHPPPPPVVVTSTSTLTYYTTEYYVITACPHKVDYCDIGHKTSTVYATGTTCYTFTYTTTVPETTYTRAVPPTRTLSTVVVSTETGYSSRTNTVYYSTTETWATSTYATQSTGTSTWMTQSIPTYPTSVKQSSSIEQPSSMEKPTSVDQPRSMSQQPSSVKQPTSMQQKPTSMQQQPTSVYQQPTSMQQQPTSVYQQPSRNAPQSMQTAPAAMKSSGSDSSPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DD42</accession>
    <accession>A0A0E0RYN2</accession>
    <name>A0A098DD42_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG08098.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T09111</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DD42"/>
    <dbReference type="STRING" id="229533.A0A098DD42"/>
    <dbReference type="ESTHER" id="gibze-i1rv36">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF76357">
        <property type="protein sequence ID" value="CEF76357"/>
        <property type="gene ID" value="FGRRES_08098_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09111"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DD42"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF8">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="19"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="528" mass="59324" checksum="796D960BB154B170" modified="2015-01-07" version="1">MGSNISYQKKSVVLDLGSKGSVRGLQYDDKACRFTGIPYAQPPTGERRWRIPVPLPESYVYGTTSELFDATDFGAVCPQKSFQLAEAAGRGGRFSEDCLFVNIWTPVPSDDASQKKPWPVMLWMHGGWFQMGDPSHEPVMDSVELISTGKLNDVVAAIGYRLNIFGFLATEALREESNGASAGNFGLWDQRLGAQWVQDNIAAFGGDPTNVTLAGRSACSFSSRVHMLHDLRDASRLDNQEPLLYRRVFMDSNSMASQPKTVAESQEQFDEVCDYFKIDSSLQSSKKLEILRSKTAEELSSMIPTLKNHFFRPVTDDLFIKQGVMEYIESPEFAAAFKPKGLKLLISEVENEETLYANFNSPTEPTIESLRAMMLNYYTPEVIDRVLALPQYPLPTNGDLTSWRNHFGQIVSDGQVRAPGRCLVESLLRNGIPISDIWRCKIAYRLSFITDKFALLEFGHGPTDEERQLMKDWIKLLAAFVQDDQDYKHGITTPDEMVVMTADKSIEVQKDTRWHELLKVGRVFAGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DM47</accession>
    <accession>A0A0E0S7M7</accession>
    <name>A0A098DM47_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T15401</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DM47"/>
    <dbReference type="EnsemblFungi" id="CEF79502">
        <property type="protein sequence ID" value="CEF79502"/>
        <property type="gene ID" value="FGRRES_12249_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15401"/>
    <dbReference type="InParanoid" id="A0A098DM47"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF79502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="113" mass="12443" checksum="94C03D0628573183" modified="2015-01-07" version="1">MWRVPFSLASRSCILLVAKAPQQTAAEAGSADSKKCAVAPAFCTTMNNMTVFYVHYVLHIVICTVQSTVPAFIYKQLICMSSGSSRKKKAYYMLKPNRNEAEVIDRLGKCVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DPP7</accession>
    <accession>A0A0E0SA64</accession>
    <name>A0A098DPP7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T23649</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DPP7"/>
    <dbReference type="EnsemblFungi" id="CEF83327">
        <property type="protein sequence ID" value="CEF83327"/>
        <property type="gene ID" value="FGRRES_15403"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23649"/>
    <dbReference type="InParanoid" id="A0A098DPP7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF83327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="89" mass="10117" checksum="B330B1FB777DCBDF" modified="2015-01-07" version="1">MWNYYDVLSRRLLSTAYYARHLQADAINAYQAQYMSPLNNECSYGTHSHEITDTSVMVYCSTGDVRVGNRICTLGPVSIRSHEMLSSMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2024-11-27" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DQ30</accession>
    <accession>A0A0E0SBX2</accession>
    <name>A0A098DQ30_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T24121</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-I/CTF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DQ30"/>
    <dbReference type="STRING" id="229533.A0A098DQ30"/>
    <dbReference type="EnsemblFungi" id="CEF83935">
        <property type="protein sequence ID" value="CEF83935"/>
        <property type="gene ID" value="FGRRES_16789"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24121"/>
    <dbReference type="eggNOG" id="ENOG502QU9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DQ30"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000939">
        <property type="term" value="C:inner kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22647">
        <property type="entry name" value="CTF3_NTD_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012485">
        <property type="entry name" value="CENP-I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208:SF2">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07778">
        <property type="entry name" value="CENP-I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF83935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="721" mass="80576" checksum="052EBF7642974866" modified="2015-01-07" version="1">METDADPAEAGHQELRLLVGDVIESSKVPAKTRATSIKPTIANLTSLSYEWGVLPETLDSLVNLVTTPNYLDQASQAAIIRNLYPAEAVSRDSVLRVVSCLGHGTLKPSLTLQAALIKWLITVHHTLESPQVLSQAYPVLFNLLDTAATRPNLSHLLALITRRRHVRPFRIQALLNLSRQTGNDPSLIGLLRVFKDYYPEVIVGEVVRGKASSFKHPDPQWRDRLDEIQEAHFYNSQEGVSRPRDGFRVHRPIGRAARKKTVPLVHTSHVTEDAVTLEEIENAVGFVKSIDKLELPNQLVAVLADPLLQKLMVLRPSSESDQRIANWLNSALQDVQYGDADEATFFEILDIFRDYVVSAKVLPSLLLDFFARFLPLWDGSQHRDSIFTILSYSPLLDFQKLYQHIFKPLEEATFDNTPESQLAVLDLYKNTLHHWTVVLESSDTIPDYASDAVADLIRHVNPLALSIAQTSTSVSARSAILDFYEQNSRLISHETLRHYIRIELPPSHLIYILFFSSSVAIMSRICAILASYKKGFEMAMLTKPKHDGSNRIDSSSYNRIFVSLFNGYLMDMCNCFWRGKAFTDSDPNAQGCLIPRSMVPILSSYIASVDKSLALTSLFSLSHSPLLCLQSMRCIQDLESAEINSGTPLRIRHEGPPTQSSLGQLVGSGGIRISWQDYRIKVLEELSANELAGITDLLKNTMTILRKLIDGGGSTRPNTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DQ43</accession>
    <accession>A0A0E0SC02</accession>
    <name>A0A098DQ43_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG06590.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T22657</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DQ43"/>
    <dbReference type="STRING" id="229533.A0A098DQ43"/>
    <dbReference type="EnsemblFungi" id="CEF83965">
        <property type="protein sequence ID" value="CEF83965"/>
        <property type="gene ID" value="FGRRES_06590_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22657"/>
    <dbReference type="eggNOG" id="ENOG502S97T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DQ43"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919">
        <property type="entry name" value="PROTEIN CBG05606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF83965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="261" mass="29118" checksum="A612AA3756EAA730" modified="2015-01-07" version="1">MVTTRASSRGASVGPEFAPEFHTELPTIPSTPSTRKRSAKAASSSSTTTASAKKRRLSVQEPKKWHHAPSTATVLWLAISLPLVAWDSGYVLGRPHTMPGGAYQWPLYMPYALYGQVDHVYGLKAWESKNGFTGAQTALNIVEMLMYLVYLWMIWRRADKTTNKKEKKRRTVSGRSGALAVLIGFSAAVMTLSKTVLYWAHEYFSEFSNISHNTPVDILTLWVIPNGFWIILPTYMVYAFGRDIVDGLTLASGQPVKQRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DQL1</accession>
    <accession>A0A0E0SB09</accession>
    <name>A0A098DQL1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T22943</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <property type="gene ID" value="FGRRES_12965_M"/>
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            <end position="75"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EnsemblFungi" id="CEF83622"/>
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    </evidence>
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    </evidence>
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</entry>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DTM6"/>
    <dbReference type="EnsemblFungi" id="CEF84704">
        <property type="protein sequence ID" value="CEF84704"/>
        <property type="gene ID" value="FGRRES_16688"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22755"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DTM6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF139">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
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        <location>
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            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="408"/>
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    </feature>
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            <begin position="420"/>
            <end position="440"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF84704.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF84704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="557" mass="60950" checksum="ED060C31BD61CBCD" modified="2015-01-07" version="1">MADTKDYPNLEAVISTDHIEKPQADHHDGHGHIEGNALIVDTKGEIRKIPVPSSDPNDPLNFRPWEKYGIVFCCCWFSIMGLSVASGLGAILNVFFEAYIPQGYNSDQVVLLITLPTLFIGLGNYIILPLSLAFGRRPVFLISTVVLFASSIAAAVQNSYNGHLASRIIQGIATGASESLLPLMLTEVTFLHERAFIFGLYWMLQNAFSSSLNLASSYINADLGWRWYYWVFTITVGVGFILAIFLGFETQSTRPAASLDGQLVVTDEFGVTRVIPDSEAQAYLEDMARSGLTPPGAGVIEDADRKTYAQRLRPWSKPSSQPIRVILLSWKYMAASFSSPGILYAVLTSSIALGCGVGMSLTYNQVLMQNYHWQAKDIGLINVGGAIGAVIAMLYCTLFANPFVMWMARRNRGIHQPEHHLITMAPPAVVGVAMLLLYGFTAGGGSTWWGPYLGWTIFQYSFTAVIIISTTFASEAAPKHPGPAIVTVVGTKNIVSFGVTYGLTPMIEQHGYKWAFGVLAGIFGAIFLLGIPVCIWNPKWRAYVAEREARKGTTTTD</sequence>
</entry>
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    <accession>A0A098DWS1</accession>
    <accession>A0A0E0SIM8</accession>
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        <submittedName>
            <fullName evidence="6">Chromosome 3, complete genome</fullName>
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    <gene>
        <name evidence="6" type="ORF">FGRAMPH1_01T16231</name>
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    <organism evidence="6 8">
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        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
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                <person name="Sykes S."/>
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                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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</entry>
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    <accession>A0A098E1E4</accession>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="FGRRES_11380_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21923"/>
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        <property type="component" value="Chromosome 3"/>
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    <proteinExistence type="predicted"/>
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            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF87910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87910"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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    </evidence>
    <sequence length="326" mass="37354" checksum="480D1DD5B043B4BC" modified="2015-01-07" version="1">MVQFTPKYYEFTPGHDVPAWALDYPKAMLSQELLKEHIRLDARMIQRAHDYFEANAKVGNHGLPNSRTIKPRHLKWARILEPKYELEDNPDDDGNFPELWVTKSGSLKKTLDEFYWYAEKVVKHPDDKCISLTETLLGRDAPEPEPEPTEPKPKSAPAPKRKPFVEYQTFGPTVPYELTTEELADIERRRKESEACGTPSEQTARSYLFDLIDTDPSARAILEKQARDDPKAAHHLELLKMKKSAADEAKEAESLTDSKEAKSVTIINNETSTEVDAQKEMVRQMYASFEDNDDVFQIERENFNMTESRCCHNVSTGCPTGILIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RV96</accession>
    <name>A0A0E0RV96_GIBZE</name>
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        <recommendedName>
            <fullName evidence="8">U4/U6 snRNA-associated-splicing factor PRP24</fullName>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a recycling factor of the spliceosome, a machinery that forms on each precursor-messenger RNA (pre-mRNA) and catalyzes the removal of introns. Chaperones the re-annealing of U4 and U6 snRNAs (small nuclear RNAs) released from previous rounds of splicing, an initial step in reforming the U4/U6-U5 tri-snRNP (small nuclear ribonucleoprotein) that can reassemble into another spliceosome complex; this step involves binding U6 and facilitating the unwinding of the U6 internal stem loop, followed by base-pairing of U6 to U4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RV96"/>
    <dbReference type="STRING" id="229533.A0A0E0RV96"/>
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        <property type="protein sequence ID" value="CEF75171"/>
        <property type="gene ID" value="FGRRES_17287_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06733"/>
    <dbReference type="eggNOG" id="KOG0128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0RV96"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.70.330:FF:000365">
        <property type="entry name" value="U4/U6 snRNA-associated-splicing factor PRP24"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="4"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
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        <property type="entry name" value="HAT"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="RBD_domain_sf"/>
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        <property type="entry name" value="RRM_dom"/>
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    <dbReference type="InterPro" id="IPR031766">
        <property type="entry name" value="RRM_occluded"/>
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    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="3"/>
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    <dbReference type="Pfam" id="PF16842">
        <property type="entry name" value="RRM_occluded"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
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        <property type="match status" value="4"/>
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    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
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    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="597"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="674"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="767"/>
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    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="895"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="508"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="978"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <begin position="574"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <begin position="1031"/>
            <end position="1040"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1060"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00093374"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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    </evidence>
    <sequence length="1075" mass="120263" checksum="8D2ED14249B67CFC" modified="2016-04-13" version="1">MVNPVGEENWLAYLEEIVRNASNLEQRVNAVEHYKLAVGCEPGSLHIWLAYCNYFWSLWEATQIPTGEGWTDEERMLGRELFSLSAALELWNQGYEAICYRLGDSHLLWDRWISLEMELLAKTRTPDGIKRITHLYRNRLLLTPHLTWDGTSQKFSTFLTEYNPSAYEDSMKDIITNAQETKRLIAARDPYESDLRKAVDADDIEAQKAAFNAYLEWEMLQSKRSNDSPEIGIDLCRGLYARALTGALATDQNTWYEYVVFLSSSNTNLQEPSSLLDVLRRAVQHCPWSGLLWNRYIMCAEEARLPFGEVESIKHAATSEDQLLKDGMEGMIEMYVAWCGFLKRNAMDAAASDEAVDVADVGLGAALEDVSVVGQRLYGKDFQGDPKFRLERIYIQYLTEKKGKVDDARKQWNKLASMQIHADNHDFWFRFYMWEMLIFSSGGGQDNRSPTPSSGGGTYRIPTLATAVLARAVARRTIDWPEKVLEVYMQHCNDYEMPLPLRKAADRVHKTGKEVKRRREREEQEKAAAYASYYTAPEPEEQAVQSSPGGSKRKRDIEPDTTDGSESNSKRQKNGSNGAGSDQTPAAQPPKRDREHATIIVSNLPFDVTQTKVRQYFKDYGHINNVTALVHDEKTDSSTALIEFSSFEEAQSALLKDGKYMNQSRLTVKSGHKLTVYVTNYPPTADQNSIRNIFRGCGEILSIRWPSLKVNTHRRFCYVSFRDQEASAKAVELNGKVLEEEKSFKLVVKYSDPGQKKAREGALAEGREIHISNLDRSISEIELKDVFSKYGNITRVNIPATLAGKNKGFAFIDFETKEEAAKAVAEMNNTKFRSQILAVALSKESRIKPAAKTIVTDNTRGSPAPSSHDVDGDQAMQDASIEAQGKPSAAEISAKTIAVMGFPDTVNDARIRALVEPLGAIVKMTVRPGNGGAEIEFVDAAMAGKASLQLNSMEFEGHKLRTGTPDDLRKAKAEYIPDRIITGRKNKDHEQKPNGPGASSTMFMPPVTALRRPVLGKPGPRRGLGFKPSSAKPTQNGESDTSVKKSNADFKAMFLASGGSEEKKEDKGETEKTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RW71</accession>
    <name>A0A0E0RW71_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG10141.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T07383</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
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        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
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            <strain>PH-1</strain>
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        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
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    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
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    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
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    <dbReference type="EnsemblFungi" id="CEF77388">
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        <property type="gene ID" value="FGRRES_20154"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0S368"/>
    <dbReference type="EnsemblFungi" id="CEF77943">
        <property type="protein sequence ID" value="CEF77943"/>
        <property type="gene ID" value="FGRRES_16311"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12279"/>
    <dbReference type="eggNOG" id="ENOG502RF8Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0S368"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="134"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="60"/>
            <end position="292"/>
        </location>
    </feature>
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        <location>
            <begin position="306"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF77943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="374" mass="40874" checksum="2A5658640EFEBA1F" modified="2016-04-13" version="1">MAASMTGEQIQALVEALPPLEPKDLGPAVQGFALAFGITSVVVLCLRLYVRAGLSDVSPRLLGIEDYLAALATLLFIPAIVFSILTTRYGVGSHDVNIPSPLYLVKATQYQTYWEVLYFISSTIIKCAIGLTCVRIDVRRRITIPIYINMGIMIIITILALAYVFANCTPFAATWNPALGSCQKEISLQLVSYIVSAIQMATDWACAIIPCFIVAELQMSRRRKVSAIAILGLGVFASVATCVRMPYLKYYDVAKYPKETAYHLAVISITSNVECCLGMIACSLPPLRKLFKFYYGSSHEGNYEITGESDRGLSNSNGGIRLDSVGGRRGTFHASAKPDTKRSRDNETDDDNSSSKGIIRKTEITVSSSSDFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0S6X1</accession>
    <name>A0A0E0S6X1_GIBZE</name>
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        <submittedName>
            <fullName evidence="8">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG04270.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T14889</name>
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    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="268"/>
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    <dbReference type="STRING" id="229533.A0A0E0S6X1"/>
    <dbReference type="EnsemblFungi" id="CEF79246">
        <property type="protein sequence ID" value="CEF79246"/>
        <property type="gene ID" value="FGRRES_04270_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14889"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A0E0S6X1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046036">
        <property type="term" value="P:CTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006256">
        <property type="term" value="P:UDP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="ASKHA_NBD_YND1-like"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF121">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATASE MIG-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="509"/>
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        <ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0S745"/>
    <dbReference type="EnsemblFungi" id="CEF79320">
        <property type="protein sequence ID" value="CEF79320"/>
        <property type="gene ID" value="FGRRES_15236"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15037"/>
    <dbReference type="InParanoid" id="A0A0E0S745"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF79320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="72" mass="8215" checksum="0C2F236D905A9954" modified="2016-04-13" version="1">MILMWHQNRASSFTGLANTQRLEALLIATMHVDLDPDAQFSSETLDHPFPRLSDVRLAHRENLGRWASGQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0S9H3</accession>
    <name>A0A0E0S9H3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 4, complete genome</fullName>
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    <organism evidence="10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0S9H3"/>
    <dbReference type="STRING" id="229533.A0A0E0S9H3"/>
    <dbReference type="EnsemblFungi" id="CEF83086">
        <property type="protein sequence ID" value="CEF83086"/>
        <property type="gene ID" value="FGRRES_16787"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24085"/>
    <dbReference type="eggNOG" id="KOG4826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0S9H3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF1">
        <property type="entry name" value="EMOPAMIL-BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="8">
        <location>
            <begin position="47"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF83086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="240" mass="27101" checksum="DAF6C6B2F6AF31FF" modified="2016-04-13" version="1">MAAETASSLPPDLFDQTTIISLLSTLAIVFTAYAASLKFLPSSSSGTLRFLFIWHLADALCHFLLEGSFLYHCFFSHLPLLNDVKTELFPTPAGFLGYSDRVYGAQSGGDNPFAMLWMVYAKADKRWAGVDLGVVSLELLTVFFDGPLAVYVCYCLARKDPKVSIWMIILATCELYGGFMTFCPEWLVGNPNLDTSNFMYLWVYLIFFNTLWVWIPLWVIWYSVKDISNALSVRQGKKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SCK7</accession>
    <name>A0A0E0SCK7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG06765.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T23131</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SCK7"/>
    <dbReference type="STRING" id="229533.A0A0E0SCK7"/>
    <dbReference type="EnsemblFungi" id="CEF84170">
        <property type="protein sequence ID" value="CEF84170"/>
        <property type="gene ID" value="FGRRES_16714"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23131"/>
    <dbReference type="eggNOG" id="KOG0133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0SCK7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF9">
        <property type="entry name" value="CRYPTOCHROME CIRCADIAN CLOCK 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="7">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="570"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="582"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="276"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="317"/>
            <end position="324"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF84170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="633" mass="72009" checksum="69BBC8A8649673BF" modified="2016-04-13" version="1">MVKPRVIYWFRTDLRLHDSPALKAALDLDPSVFWPIFTWDPHYVYRARGGLNRWQFLLDCQNDLSKSITKVNSNSKLFVLREAPQTLFPKLFKAWKVTHIVFEKDTDSYARERDSIVTQAAKDAGVEVIIRSGRTLWDSDQIVEKHGGKPTMSITQLQAAGSKLGQVKKPIPAPKNLPDPGDMPVNFDQDEPDTKPDFNSEIRTEGDKTYTKISGPKGDFAIETMEELGFPPATTPHRGGETLALKALDEIIADKKYTATFQKPKTSPAQFEPQATTLLSPHLHFGSLSVREFYWRVKDVVDSYKGASSPPESLIGQLLFRDMYFAAQAALGYVFSQTANNPYCRFIPWHLPSKRDPETGLVTGEYHVDSEEADIWFKRWKAGMTGFPWIDALMRQLKDEGWIHHLGRHAVACFLTRGGCYIDWERGCEVFEEWLIDHEPACNVGNWQWLSCSAFFSQYFRCYSPVAFGQKWDKKGEFIRRYVPELKNMDAKYIYEPWKAPLTDQKKAGVRVKGDGLNNVEEGTYPKPMFDFAKRRDVCISSMKVAYQVGLHGNDGQALDGTWRKLFPTDRGEVQGDVESGYGEHADEEGKSDNEAKEEGEGTSSVKKEDDTTKGKRSARRHSTEKVPKKKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SIR9</accession>
    <name>A0A0E0SIR9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T19197</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SIR9"/>
    <dbReference type="EnsemblFungi" id="CEF86332">
        <property type="protein sequence ID" value="CEF86332"/>
        <property type="gene ID" value="FGRRES_20281"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19197"/>
    <dbReference type="InParanoid" id="A0A0E0SIR9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF86332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="51" mass="6253" checksum="635B19810211F8BC" modified="2016-04-13" version="1">MEPCRKFVSIVLRTKHFQSINWYMYESTRYQDRLTLFARLEMLVCSEICCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YHQ3</accession>
    <name>A0A1C3YHQ3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T02027</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YHQ3"/>
    <dbReference type="STRING" id="229533.A0A1C3YHQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02027"/>
    <dbReference type="eggNOG" id="KOG0068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YHQ3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12169">
        <property type="entry name" value="PGDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
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    </dbReference>
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        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="6">
        <location>
            <begin position="89"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="7">
        <location>
            <begin position="174"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SCB64124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="402" mass="44419" checksum="AD52013FB89FEF30" modified="2016-11-02" version="1">MISHSLCNCFGRFATVRHFTHTPSLASYISSPPPRNIRQPSRMALTKVAILDDYQGIADPFFAKLDSSKYQVVSLKDTVLPYNHPDNTQEGRDVLVERLKPYEVICTMRERTPFPAELIKRLPSLKLLLTTAFRNRSLDMDALKARGIPVAGTVVKPQSGKKTGGVSSTVQHCITLILALARGIARDDAAMKEGLWQTGLAADLSGKTLGVLGLGRLGSDVARILHVAFGMRIIAWSTNLTQEAADEKAREAGLSVEDEDGEKTFKVVSRDELFSDADVVSVHLVLSDRSRGIINSQDLAKMKPTSLFVNTSRGPLVVEKDLLDHLKGGHIRGAAVDVFDLEPLPKDSEWRSKNWGRDGSSQVLLTPHMGYVEGDTMKSWYEQQVENIERWAANEPLENVMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YHW3</accession>
    <name>A0A1C3YHW3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T02759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YHW3"/>
    <dbReference type="STRING" id="229533.A0A1C3YHW3"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02759"/>
    <dbReference type="eggNOG" id="KOG2295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YHW3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF2">
        <property type="entry name" value="RESISTANCE PROTEIN ARS2, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="669"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB64184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="868" mass="98408" checksum="57AD56F0FBCB3AD3" modified="2016-11-02" version="1">MDSYTSFRDASARSPVDRSWNRDDSRNRDERPDRGDSFYRGRSPGHDRRDRRRSRSPAAVDRYEPRPRRGDDRDRDDRRRIQSPPANIDRYVPGQDSSTGSPSVNPLHDPSKLPYQVGFSYFGEWWRINEKMKEEKERARTGRRREPERTRGPEDREKEKAKIQAAYDAYKEELQAKMARSFVSEHKKEQWFKERYVPEIRDDFRGKLNESRRGAYSQWEQDLESGTFDDFSLEGLPKSESNGSGGVVEKEEGEATATNEILGVGDLVPANGADIRDENQFQPTLLIKTIAPHVSRQNLEAFCKEHLGEEEGGFKWLSLSDPNPSKRYHRIGWVMLHPSSETTLPGDRIDPKDEDGDESLKSPQPVSTAEKALEAINGKTVKDEVRGDFVCHVGVHNPPVHPRKKALWDLFSAPERIDKDLLLVQRIVNKFEEDFGSDFQATLKIEEKVEDLRNAGQLQPAVVPAPVKKVKKTREVGMDEAMDEEEDGVIDIEEDEEEEEEEGAVEDEEVDDEDLLVKKKQLDLLIEYLRRVFNFCFFCVFESDSIHELTRKCPGGHLRRPRSTLSSTAKAVARASANGDPFPGKKRSEDDAEGELTESEKKFRNTSNKTEQQLLRAFNWVKTFEDKLTQILDPLSVDIRKLGGRPANEAVEEELLKHVKQEDEHKWRCKAPDCSKLFKEEHFWRKHVEKRHNDWVDTLKHEFELINAYVMDPSHIAPSRTDANSNGHFPTSNGQSSSGTPRGFNLQNFSMNGMMGMPGFPMPPGNFNPMFANMPPGGWPPMGDDRSGGGPIRRGGMSGGRGQYRSGPYDRRGGPRFDGARNRNGGSRWGDGAGGAAGGPREAVQGRSLKSYEDLDQVSGGGSGELNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YIH5</accession>
    <name>A0A1C3YIH5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T05145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YIH5"/>
    <dbReference type="STRING" id="229533.A0A1C3YIH5"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05145"/>
    <dbReference type="eggNOG" id="ENOG502TGWG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YIH5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SCB64373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="276" mass="31077" checksum="7AF33AF7DDDF61F8" modified="2016-11-02" version="1">MSVYQLMFVFGKSGSYLLDHPKKCTRRNMPQALIRSINKNPVQEVQSLALDANDNYFLRWTDESDSSWYSYIGLKTHYPALVEFFDEHDEHTSTVTFGPTIGDFFVFNQKTWQYEGRGLNLPDWLSDDNRQIKQVALGMNGAHCILFTNGEWTVACENNYPELYDILNDHERGDVVFVAMNPNRKNEFFLALADNTIHVQASAICEADIVDVLSAYEELEIITSHVSNFSHNLTEKPKLPQSARKGAFLKGIATSVGKGVLSSIVTTALTASCSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJ91</accession>
    <name>A0A1C3YJ91_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FGRAMPH1_01T07427</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJ91"/>
    <dbReference type="STRING" id="229533.A0A1C3YJ91"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07427"/>
    <dbReference type="eggNOG" id="ENOG502S2SN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJ91"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="516"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="542"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="368"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="674"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SCB64562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="753" mass="84640" checksum="B488029276ABC1AF" modified="2016-11-02" version="1">MDSFNSLQDRRNSSTMSPQIAQQNVNLAGLGQPRSQTTSSFYPNWSGAGDDLMTPLSYDSSSARSQIFGSANFQTSYQDYRSKPLLSECDTNPEDSAYGSRLTHSIGNHSTYGEDLDPDIQTLDSQNADTQLVNSNLESLQLQCRTAGNDSQQYQEQWARPRRPASVAATPTSGEKRWGCRECQQSCRTRSELRKHELKHTRPWRCNVSGCSRIKGFTSKNDLDRHKRTVHSDQTVSGRAFVCNIGSCAKKTKIWPRADNFRNHLERMHQKSYSANDDLTEYVYRPIPSQGLEGIGGSAMAYLQAQEQSPGLAHPSTILSSRGHSGDRRTSQLQLGISGLSRGPACISIERDISGLAPVRESEENFIRPDILSGPIPVPQDRWPGPSLSGEDAPGDYITTSESGQHDDATPDDMDGVQESGTSETGASSVSDNSNSQQPDIGMMDVDEAQQTPRAVILSDQSSLDSSNISPNLTYEILDKIPKEVIASYMKKHSTEIRDETPKPDVPGGKSQGHIYKCQDCDKMFPRLCELKKHQKRHSKPYGCTSINCNKTFGSKNDWKRHESIQHYQLETWVCDCTKSGTRELCGKICHRRESFRNHLTKEHKVSDQHELEEKVDTCRKGRHCDAHFWCGFCEETIETKETDNTWTKRCDHIDDHFSGRDVAQRHISEWVHEKDPSTGITASVGAAPESSSISFVPDTNPPQPSTSEDNSIEDRRNWKDTYMWICCDCNNENSFRHNTVCFECNRRKSLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJA0</accession>
    <name>A0A1C3YJA0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T06821</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06821"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJA0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF64">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="385"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="414"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="452"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="458"/>
            <end position="479"/>
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    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="69"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SCB64511.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="499" mass="53842" checksum="CA54BE34D7DF6B7B" modified="2016-11-02" version="1">MGDTEASLQIMASNPNQAIETINRATSHISGPDAFEPAATIETPEGDEPYREAGDEIFGKVSRGRKIAIVAVLSFGAFLSPISSTSVLAATPEVAATYNTSGSVINLSNAAYMIVMALSPLFWGPMSQVHGRRIVALYSSAMFFLLSLATALAPNLASFIVFRAASAFGGTAFILIGPACIGDIYRPTERGAAMGWFLTGTLVGPAFGPFLGGIIVTYSSWRTIFWLQTALAAAGFLGVYFVVTETAHHLKIDDLKTLSGKKRALTILSMISPMRVLRLFQYPNIALVAGGSASLTWNMYSLLTPIRYVLNPRFKLESPLLSGLFYLAPGFGYLAGTFVGGRWADYTVKRWIKKRGVRVPEDRLRSTVPFMGAIIPGSMLVYGWTVDQEAGGIPVPVIAMFVQGVAQLFCFPSYNTYCLDVMPGQGAEVAATNFFARYLVGCVASAVVLPAIEAVGIGWFSIISVAYLIVSALATMAAIRWGKCWRERMEAKLENSREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJC3</accession>
    <name>A0A1C3YJC3_GIBZE</name>
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        <recommendedName>
            <fullName evidence="2">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FGRAMPH1_01T06545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG3077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJC3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="321" mass="36220" checksum="BAF00A41A83272F6" modified="2016-11-02" version="1">MPPPSANQQKVLIAQFVSLTGQTERQATRYLKNAGFKLNEAVDAFKMGWKGVKNRIATRVPIWSASKKASTDGPASFYQEPAAKPPKNSTSRYFASSGDSKGPSPLETKLDALFDQLQDTNDEKDKLELESTMSYLTDKLNVSIENAELLVALELLQAPAVGIITRRGYVDGWKVTGAGTTHQEHATHLRKLIKSLSSDQALFKKVYRHAFVAGRETDQKALSLENAFVYWEILFTPPGMEWKTSNHDWLQLWKDFLKAKWTRSVNKDMWNMTLEFALKSLSDESLSFWNEDGAWPSVIDDFVEWCRENGIAKTDGMDVDN</sequence>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJH0"/>
    <dbReference type="STRING" id="229533.A0A1C3YJH0"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06771"/>
    <dbReference type="eggNOG" id="ENOG502RJUT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJH0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="177"/>
        </location>
    </feature>
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        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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            <taxon>Fusarium</taxon>
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
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                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970334">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="229533.A0A1C3YKC2"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20933"/>
    <dbReference type="eggNOG" id="ENOG502QS5N">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A1C3YKC2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="GAL4"/>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
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        <property type="entry name" value="XnlR_reg_dom"/>
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        <property type="entry name" value="Zn_clus"/>
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    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="454"/>
            <end position="478"/>
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            <begin position="26"/>
            <end position="57"/>
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            <begin position="572"/>
            <end position="590"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SCB64984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKC4</accession>
    <name>A0A1C3YKC4_GIBZE</name>
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        <name evidence="1" type="ORF">FGRAMPH1_01T19273</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKC4"/>
    <dbReference type="STRING" id="229533.A0A1C3YKC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19273"/>
    <dbReference type="eggNOG" id="ENOG502SDNM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YKC4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SCB64847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="150" mass="17556" checksum="88B483774246E2F6" modified="2016-11-02" version="1">MQLLAHHELPIFNHTQTTSIIMASTTQISHAYRSLYRNILRAVQYSSPARFVARDQLRRAFREPGATYDERGIKRTNWFLEAAAKEKGMEHRILKNLLRVQKMRFRKRAYSSYDPLKYADNETKVANATAYNHYDMTVAMLNKSMGTLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKG8</accession>
    <name>A0A1C3YKG8_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
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    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T21975</name>
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    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB65041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKG8"/>
    <dbReference type="STRING" id="229533.A0A1C3YKG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21975"/>
    <dbReference type="eggNOG" id="ENOG502T6DJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YKG8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB65041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="404" mass="44872" checksum="194BA22F8512AEB2" modified="2016-11-02" version="1">MSDRSPNEETAGVDTPGVRTPRALSQNLDVDTITQQLSACLQTPQGNPPFIAPVGFDEALSATDHSEPISKAFKQRGFWPWLAYFLVTKNGDKLSYFFECLSALPLDIVSDIAGRVASVPVEPTLVMRLQNTLWTARRGSQRRSQLQQLGIHDFPPAPTSSPLPEPSPRKRPRVQPLHNYDNTTSAIDRRNFHSIVSDIPQTGDANTPYYPARDKPVEWPRIVENTNPWTPDPDSLHNYAYPNASKIPLVFSPELGDMIVRNENFTASIFASFPSNPDRCRLVLDIEAGMVAPLAMKLYDAQVVETGRQRAFRLPSGAILEIMSAVRLTNTKLSRWEELLGSLIGGVRNAQEYVNEVGHGLAMTKCLAMEVPGATNSPARISLVMDPMVLDDVIKKLWPPERSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLB0</accession>
    <name>A0A1C3YLB0_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FGRAMPH1_01T24593</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YLB0"/>
    <dbReference type="FunCoup" id="A0A1C3YLB0">
        <property type="interactions" value="486"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YLB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24593"/>
    <dbReference type="InParanoid" id="A0A1C3YLB0"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SCB65246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="146" mass="16586" checksum="62BA74437BC4B53B" modified="2016-11-02" version="1">MSAFIRVARGVRAAPIRPAMQPLVARSAVAHFTTSMPRRSEHAEETFEEFSARFEKEFDGVQDVFELQRNLNNAFAYDLVPAPSVIAAALKAARRVNDFGTAVRIFEGIKTKVENKGQYEQYLEELKPLREELGVPLKEELYPEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLT1</accession>
    <name>A0A1C3YLT1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NCT transcriptional regulatory complex subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Negative cofactor 2 B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T27641</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B. The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Forms the NCT transcriptional regulatory complex with nctA and mot1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1C3YLT1">
        <property type="interactions" value="874"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YLT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27641"/>
    <dbReference type="eggNOG" id="KOG0871">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YLT1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017055">
        <property type="term" value="P:negative regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000019">
        <property type="entry name" value="Negative cofactor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="7">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00053814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00065193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00072420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00079659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SCB65495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="149" mass="16463" checksum="747B2039EBD4F562" modified="2016-11-02" version="1">MPLPASTKYWQKYDNGTLGNEDLSLPKATVQKIVSEILPPQAGVAFAKEARDLLIECCVEFITLISSEANEISEKEAKKTIACDHITKALEQLGFTDMVPAVLEAAAEHKEVQKGREKKADKFANSGMSMEELARLQEEQFAAARERHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YN42</accession>
    <name>A0A1C3YN42_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T13811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YN42"/>
    <dbReference type="STRING" id="229533.A0A1C3YN42"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13811"/>
    <dbReference type="InParanoid" id="A0A1C3YN42"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SCB65863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="497" mass="55310" checksum="2C7B3F6D586E4190" modified="2016-11-02" version="1">MPDTTETKNGAKRARLPTSDPKYPLRSIAASQSHVALGPGASQDQLQFNGSLNSDTTVQLQHQLHTADWFTAQSESASTTPASSASAAAVRWFGILSNEAPNEEFLEAETLQGDLLDTSPEGRADSDITPLQRATRAIDTQPEISDRRNSRTSNISEESLWQASKSISLLDQEQGLFQNFLHRICSWLDLFDPARTFSTRVPHLAVRNAGLLNAILALSSYHRSLDDSIPSNQRPDQNIALQYYYQTLHYVQKAMRYSTYQNSHELMATTLMVSTCLSYTKIKTDRSGNIESGKYDVVGLAATRYMGGFSAVWIMAQVINFCAVDSSIEMEGGLSRRIDWAKALKNMLNEWQSHLTVEFSALPSMGQYGIEVFKPHLIHPQCFGLAVQLHHCSWILITAHEPHLDGIQGLLKRQKDIQQSIDMVCGIGMTLTEDASSMLSSQCLFIAGMFMQNPRQKEAVLDMLDSCQKRCGWPTPSLGSELEQIWKSPDALWGIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I1R9F8</accession>
    <accession>A0A098D0K4</accession>
    <name>I1R9F8_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG00096.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T00281</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF71940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315695.1">
        <property type="nucleotide sequence ID" value="XM_011317393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1R9F8"/>
    <dbReference type="STRING" id="229533.I1R9F8"/>
    <dbReference type="EnsemblFungi" id="CEF71940">
        <property type="protein sequence ID" value="CEF71940"/>
        <property type="gene ID" value="FGRRES_00096"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00096"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00281"/>
    <dbReference type="eggNOG" id="KOG2024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002346_0_0_1"/>
    <dbReference type="InParanoid" id="I1R9F8"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005990">
        <property type="term" value="P:lactose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050347">
        <property type="entry name" value="Bact_Beta-galactosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323:SF2">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="LacZ_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta galactosidase small chain/" evidence="7">
        <location>
            <begin position="726"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF71940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF71940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1003" mass="113947" checksum="A2080E03FE30C734" modified="2012-06-13" version="1">MSVGAFPGALPDWTNLNVLQRNTLPPRAHFYSYPDQESALSFNRDQSLFHSLNGTWKFHYDPSPLDAPIWETANTTSWDDIEVPGMWQLQGYGAPHYTNIDYPFSVTPPNVSYVNPTGSYWRQFEVPEDWEGDQIRLRFEGVDSAFHVRVNGEDVGYAQGSRNPHEFDITDYLSSDKANELAVRVYQWSDGSYIEDQDQWWLSGIFRDVYLIPFSESSIIDYQVDSELSDSFDQGSIKVNVTVQGQEGDLAINLLSANGSTIDEWKGSSSEIYKKQISGDDFHLWSAETPYLYTLLITYNGRTISQKAGLRRVEMKGPNFYVNGKPIIIYGVNRHEHHHLTGRTVSYENMRKDLILMKKSNINAIRAAHQPHHPDFFDVADELGFYIIGEADLECHGFRSFEDTEEKAAEWLSNNPDWEDAYIDRARQLVERYKNHASIIIWSLGNECFYGQNHAAMSKWIRERDPSRIIHYEQDHEAKSTDMYSQMYTTPDYVRQFIKDHGDKPVLLCEFAHAMGNGPGGLVEYIDMFRTEPLSQGGLVWEWSNHGILKEEGNVTYYAYGGDFGDHPNDADFIMDGLTLSDHSPMPSLREYAKVIQPVSVLLAKNGSAITITNHYDFLDLSHLDASWHVVADGVKTDPQSLSLPRVPPGENRTLAIPSVENITTGDCWVTLEFKLKEDTLWATEGHLIAWDQLHIERPASASKNAASLTRRANTSEFERKGTSLSYKNGDSSFGFDLLQGNVTWTKNGVDIFQRGPELSFYRALTQNDASGSGDGPMWDRARIPMIYPQVRDVTWKTDEDGATVHYKVWVGVKTQAWGIEADMIYKIPSSGPELQLQASGEFIGKNSSHTIPRIGLMAVLPESFDDVSWFGRGPGESYKDSKQAGRIGEYSSNVPDLFTHYDYPQENGNREDLRWLKIGNKDAALDARRAKGETFTFTARRYMPFDLDDAKHPHDLKPLNMTVLHLDYDSNGLGSATVAVRPFEQHRCYMKAFDFTFDFSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1R9F9</accession>
    <accession>A0A098D1X1</accession>
    <name>I1R9F9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG00097.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T00283</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CEF71941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="EnsemblFungi" id="CEF71941">
        <property type="protein sequence ID" value="CEF71941"/>
        <property type="gene ID" value="FGRRES_00097"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="protein sequence ID" value="CEF72089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_011317535.1"/>
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    <dbReference type="AlphaFoldDB" id="I1R9Q8"/>
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        <property type="protein sequence ID" value="CEF72089"/>
        <property type="gene ID" value="FGRRES_00213"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00575"/>
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        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_2G04560)"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="308" mass="33495" checksum="CB5A579932A25AF0" modified="2012-06-13" version="1">MSDYKTYSFNPAQDIPSLDGKVILITGANTGLGKATALELAKHNPAHIYITARNSTKGNTALEEVKGVASEGTQVSLLELDLSSFDSIKAAAKDFLDREVRLDVLLLNAGVMGAPPVLTKDGYEMHIGTNHLGHALLLKLLTPVLDKTPNARVVHLFSAGFRHVGPNGIEFDTLKSATSPTPLPLRYAQSKLACLLYAREAAKRYNFTNIAINPGEVQTELFSRKAGDEMMKHLQENVAPKMAGPISEGVKNHLWAATSTEIKNGEFYEPVGKTGGLEGAGLDEEMANKLWDWTEEQLEGLRVSEIDR</sequence>
</entry>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
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                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_011317836.1"/>
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    <dbReference type="EnsemblFungi" id="CEF72403">
        <property type="protein sequence ID" value="CEF72403"/>
        <property type="gene ID" value="FGRRES_00468"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01203"/>
    <dbReference type="eggNOG" id="KOG0272">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_000288_57_20_1"/>
    <dbReference type="InParanoid" id="I1RAE1"/>
    <dbReference type="OrthoDB" id="540662at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:U4 snRNA binding"/>
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        <property type="entry name" value="Putative pre-mRNA splicing factor"/>
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        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
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        <property type="entry name" value="PRP4-like_sf"/>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
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    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
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        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="7"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="WD_REPEATS_1"/>
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        <property type="match status" value="5"/>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="63"/>
            <end position="113"/>
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        <location>
            <begin position="479"/>
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        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF72403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="518" mass="57122" checksum="EC05604981C4D945" modified="2012-06-13" version="1">MMHPSRQAYVEDVEPQGIALEDVPDDHDYDISMGGTGVPSEKASAILNQFNRKRLAATIAVPTDDTRVRAKLREMGEPVTLFGEALVDRRDRLRELLTIQAEITGLENGDIDMGDADDDQEEDQEEEFYSRGGPELQQARLKIAEYSLPRAKKRTQFQKAESTIPLRTHVKFRKQVKERLQAFELQGSQTVGERHVSMTRISPNGELVAVGNWGGQVKLVEIPSLNQKMNFRGHTNKISGLSWFPGATLQENNVSPDSVNLASGGAEGSIHMWSLNQDTPLATLEGHSQRVCRIEFHPSGRHLASASEDTSWRLWDVETTTEVLLQEGHSRGVYAVSFNTDGSLLASAGLDSIGRIWDLRSGRTVMILDGHLDGHIKPIHALDWSSDGHRVLSGSADGWIKCWDVRKVQRTGGVGAHTSAVSDMRWYKGLDDPLTGVPPGVDEKGAQLPKKSGTFFISSGFDRNVKVFSADDWTLVQTLSGHTGPVASVDYSRDGKWIVSGGHDRTVKLWGRNDGEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>I1RAM6</accession>
    <name>I1RAM6_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FGRAMPH1_01T01421</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316239.1">
        <property type="nucleotide sequence ID" value="XM_011317937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RAM6"/>
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    </dbReference>
    <dbReference type="STRING" id="229533.I1RAM6"/>
    <dbReference type="KEGG" id="fgr:FGSG_00558"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01421"/>
    <dbReference type="eggNOG" id="KOG0358">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_9_1_1"/>
    <dbReference type="InParanoid" id="I1RAM6"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SCB64078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="537" mass="57155" checksum="6574AA9BFFA1C6CD" modified="2012-06-13" version="1">MSAPAMASAPAGGASSNATFRDKEKPMAVRSSNIVAARAVADAIRTSLGPRGMDKMIRGGKGETIITNDGNTMLKSMAVMHPTAKMLVNLSGAQDVEAGDGTTSVVVICGSLLGAADRLLSKGIHPSVISESFQRAAAAAVEVLHDMSLPITLSDTSSLLQAANTSLSSKIVSQYSNLLGPMAVNSVTKTIDLKTADNVDLKNIRIVKRVGGTIEDSELVDGLVLTQPVLKNGGGPARMEKARIGLIQFQLSPPKPDMENTIQVNDYRQMDKIVKEERLYLLNMAKKIKKAKCNVLLIQKSILRDAVNDLSLHFLAKLGILAVKDIERDEVEFICKSTGCKPIADIDSFTEDKLGYADLVEEVQSSGSRMIKVTGTKSVGKTVSVVVRGANSLILEEAERSLHDALCVVRCLVKKKALIAGGGAPEIEIAAQLSKQARSLTGTEAICWKAFADALEVIPTTLAENAGLNSIKVVTELRHRHEMGDKNAGVSIKSGGVNTNISKENVLQPLLVSTSAIELAAETVKMILRIDDIALTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RB87</accession>
    <accession>A0A098D2X8</accession>
    <name>I1RB87_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-homologous end-joining factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG00796.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T01997</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the XRCC4-XLF family. XLF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316509.1">
        <property type="nucleotide sequence ID" value="XM_011318207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RB87"/>
    <dbReference type="STRING" id="229533.I1RB87"/>
    <dbReference type="EnsemblFungi" id="CEF72800">
        <property type="protein sequence ID" value="CEF72800"/>
        <property type="gene ID" value="FGRRES_00796"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00796"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01997"/>
    <dbReference type="eggNOG" id="ENOG502SCQK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022898_1_0_1"/>
    <dbReference type="InParanoid" id="I1RB87"/>
    <dbReference type="OrthoDB" id="2155935at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045027">
        <property type="term" value="F:DNA end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22285">
        <property type="entry name" value="HD_XLF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.10">
        <property type="entry name" value="DNA double-strand break repair and VJ recombination XRCC4, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052287">
        <property type="entry name" value="NHEJ_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053829">
        <property type="entry name" value="XLF-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015381">
        <property type="entry name" value="XLF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038051">
        <property type="entry name" value="XRCC4-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235:SF1">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09302">
        <property type="entry name" value="XLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21928">
        <property type="entry name" value="XLF_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XLF-like N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="XLF-like coiled-coil region" evidence="10">
        <location>
            <begin position="134"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="298"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="478"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF72800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="541" mass="59363" checksum="A38FE2964DB61B5A" modified="2012-06-13" version="1">MSLNKSWRPLPLQPSPDLPVLLVSFHTETSAYTIHITDMANMWTESLDRKQISMRGWNENTSIDPSETQDNMAKFLASISTALDSSQPGHYETSLCLDHDDRSEAGEDDLVLRITCEIPELQPLQWPMYLKKLPAINIATNLVLPLIQTHHAKDLEIASLIQSLGQKDAVLTRLLDKLEAMGTGMEHIFNALSGKKKVSRAVAAEKVPGLAPFDRRRWKADLLYKQDSPNNPQSLVESVFENGGLEFEPMSNSTESPQLDQWWQNFEGVSSVAYQQQHKAAVADSSLIPKGAGIIPVEDGDDDFQVQSTPPHLTSKRKSIDAKETLAADDASTEGESAGSVSPVRNAQRVDKPTRRLGALGKKKQSTPPPSPGPVLSQRRSDSKNQQQDDSETASEAEEDDAVVSPPAKDPTPSSVSPARPLAKKRGLGRIGGAKSKLPVEKSSALDEPEVIEISESSTAAVSHRPPRKLGIIGRQTTKVDESTPNSDERGQRGRSAVKEATPEPKARETSQEKADRRREEIKKDLEKKVAAGPAKKKRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1RC19</accession>
    <name>I1RC19_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG01120.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T02791</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316887.1">
        <property type="nucleotide sequence ID" value="XM_011318585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RC19"/>
    <dbReference type="STRING" id="229533.I1RC19"/>
    <dbReference type="EnsemblFungi" id="CEF73197">
        <property type="protein sequence ID" value="CEF73197"/>
        <property type="gene ID" value="FGRRES_01120"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01120"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02791"/>
    <dbReference type="eggNOG" id="ENOG502RDBT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005788_0_0_1"/>
    <dbReference type="InParanoid" id="I1RC19"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF92">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="727"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF73197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="987" mass="109910" checksum="8FE77A8CC58B8B02" modified="2012-06-13" version="1">MADTQNRYYPLDSSLARKHRGRLNPIIEEDSDDGMAQHGGRRLRRTGNAQLKIEAWLTPMSDHFPTPRGMHYLSAPVLPSSPSADSATDTSPTTSSNPWNRQSVATEATEFEDLYDVTDDEDDMVRRRASAKSRQAPTKQPTPLVIPATRDNTVESWSAVDNMKKSLTSPVPLTPSVKLTMSPAQMEFMHEQHAAPTPTMSAPPSLDGSLTSEQLAAMSAPPTPIIGNEESVTDDAWAGVQLQPGALATLQALASGEENPHEQPSQVLEVHEQQPVHQIMEMRQQPLRLITSFQPQSAINRAFSPNTNRQSLADLTKLDIPSPGGFFSGLSPRTRNTWHMPSKSPEDMAPPTSTTAEQFYRCPWNADASVPSVPKRKDFVEDFYRNVRFTPAPTEPIVEQVVELKEEDDFSDDMPTARPVFEHKTAPSTVESVEAPASPQAEDAPTEIVVDYDPDYARKQQKEALSHFDRTELWLMAQRSYLRGVQDDTSEDDGGLNTIAEEAEDEAEPSMIQSALPPLKVQPEQSIAPLKKSVRFSNLVSTSDHPKRLPSMLVRRESAYYRAFQDYIIRIQRQDVFVHQLARFEAIQAQRVSLRESHRNQLLGKYQLSVVPQSAKKRLSANVARGDDTIIDDPEKLRHEKEVEAMNQMTVAAWHVAAMKMLNGGRLISAPVTKRLARLSRAAPNKSGVVRERARVLDLGGQTTCDWAWHCALQYPNTKVYTVTTKSIRQLSNCNVRGPPNHRQVAVEKFSRLPFADDQFDLISARELHSILKLFGENGEDEWDTCLKECMRVLKPGGYLDFSLLDSDIINAGPVGLAKSVEFGFALKTLGYDPNPTKLWLARLARAGFQDTRRIWMCLPMGARRSMYKPPTPPMKDSPDGQDVKTCQMDAMVMGSSDDIASACSIAGGWNWERWLLRCEMEKVAGELRLADTTTTGTAMEEAGKCLDGVAAVFEEGRNCKSGFRMLNGYAQKPKAGTETIKIALRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1RCN4</accession>
    <name>I1RCN4_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG01355.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T03339</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317146.1">
        <property type="nucleotide sequence ID" value="XM_011318844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RCN4"/>
    <dbReference type="FunCoup" id="I1RCN4">
        <property type="interactions" value="1619"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RCN4"/>
    <dbReference type="EnsemblFungi" id="CEF73475">
        <property type="protein sequence ID" value="CEF73475"/>
        <property type="gene ID" value="FGRRES_01355"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01355"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03339"/>
    <dbReference type="eggNOG" id="KOG2920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038704_1_0_1"/>
    <dbReference type="InParanoid" id="I1RCN4"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045903">
        <property type="term" value="P:positive regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF73475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="359" mass="38925" checksum="5CA784D5069F25D5" modified="2012-06-13" version="1">MSFSFGFAGDDISEDEQNSSTVKPTAPAPAATNSAFPVAGKPQLPPTLHQLSDLLAQQPSKIAYSLLYVELDDGTTVQLPRRELWDVRVQLMAEEENLAGAQSEGLGSHDVKTGVYEGGFKSWESSVDLVKVLAANKAISTLEQKPFRVMELGCGTALPSLAVFQWAMTSKSERKPLSLILADYNPSVLQLVTLPNFILSWALNNTQLPALQEAFSIEGEVELGPDVLAAFQQSLQESNITLSFMSGAWSQEFVDLLYTLPSGNGQPNATLILGAETIYSPFALQAFLETLFLILERERDTEGSQAGAYIGAKRLYFGVGGSLDDFIDKARQKGAKVEQLREEAEGVRRGVVECVLGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1RCP4</accession>
    <name>I1RCP4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG01368.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T03375</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317164.1">
        <property type="nucleotide sequence ID" value="XM_011318862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RCP4"/>
    <dbReference type="EnsemblFungi" id="CEF73492">
        <property type="protein sequence ID" value="CEF73492"/>
        <property type="gene ID" value="FGRRES_01368"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01368"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03375"/>
    <dbReference type="eggNOG" id="ENOG502SQGD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068709_1_1_1"/>
    <dbReference type="InParanoid" id="I1RCP4"/>
    <dbReference type="OrthoDB" id="5410926at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599:SF1">
        <property type="entry name" value="GPI-ANCHORED PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599">
        <property type="entry name" value="GPI-ANCHORED PROTEIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124042" evidence="1">
        <location>
            <begin position="19"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF73492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="237" mass="23884" checksum="F6DABE2A9FB89B71" modified="2012-06-13" version="1">MLGYSCFLLAFVAASTSAQNIPEVPAIATATSTAIYYPTYIPPASVIFKRDDSCPANTFRCSEELGERFRDICCQNGQTCAVDADDEPACCPSGAICTGTAPASATGAATASPSFVPNSYFAFPYAAATFENEASCTSAVSACGENYDQCVNYLGDGGQYGVTIVVPGGGGTTVEGGGQALGSSSATAVCSSLSSRACGNVSSADCSDYGNHASSSNSPGLWVASLSAGITLLSFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1RDU8</accession>
    <name>I1RDU8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG01815.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T04395</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317655.1">
        <property type="nucleotide sequence ID" value="XM_011319353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RDU8"/>
    <dbReference type="STRING" id="229533.I1RDU8"/>
    <dbReference type="EnsemblFungi" id="CEF74004">
        <property type="protein sequence ID" value="CEF74004"/>
        <property type="gene ID" value="FGRRES_01815"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01815"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04395"/>
    <dbReference type="eggNOG" id="ENOG502SRTV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102245_0_0_1"/>
    <dbReference type="InParanoid" id="I1RDU8"/>
    <dbReference type="OrthoDB" id="2943660at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124115" evidence="1">
        <location>
            <begin position="20"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF74004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="170" mass="18947" checksum="C4F809BC46567C94" modified="2012-06-13" version="1">MLGSKILFLIAATSNVVFAAYGCGEVNVVYTGLPGRHKYVKEQGGDPDVTEKNIEDYTREMREAGYNVRGIWRGPEIEGSEFAENVKGVDWHAAGVGFGVRGSNMTDLTGLFEENLAIYREEAPDAKFVFNYNPRSFLWSVKRYFPISTDCKDHPGKDLGFITLCDEACN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>I1RDZ4</accession>
    <accession>A0A098D537</accession>
    <name>I1RDZ4_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7 11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">FG01863.1</name>
        <name evidence="14" type="ORF">FGRAMPH1_01T04515</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 10 11">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7 11"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317712.1">
        <property type="nucleotide sequence ID" value="XM_011319410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RDZ4"/>
    <dbReference type="STRING" id="229533.I1RDZ4"/>
    <dbReference type="EnsemblFungi" id="CEF74064">
        <property type="protein sequence ID" value="CEF74064"/>
        <property type="gene ID" value="FGRRES_01863"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01863"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04515"/>
    <dbReference type="eggNOG" id="KOG2778">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018316_1_0_1"/>
    <dbReference type="InParanoid" id="I1RDZ4"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071629">
        <property type="term" value="P:cytoplasm protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09617">
        <property type="entry name" value="Peptidase_C12_UCH37_BAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000009">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017390">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038120">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="13">
        <location>
            <begin position="4"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 10">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="9 10">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CEF74064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="327" mass="36234" checksum="2D07C4E6ABCFF16C" modified="2012-06-13" version="1">MSGGWNTIESDAGVFTSLIENLGVKDVQFEELLTLDPSELLTLHPVYGVIFLFKYPTDQPYATPEGPRDGSFDHAASENIFFAAQTIQNACATQALLSVLLNKTKDVEVGEQLGDFREFTMVLPPEFRGEALSNSDLIREVHNSFARSSPFADETDKTGAETEDAFHFIAYTPINGTLYELDGLQPAPISHGACSSEEFSTKVVDVLQRRIARYDSTEIRFNLLAMCRDLRQRARDFGDEELLAREERKRRDWMFENALRRHNFVGFAGEVMKGVVRSKIAEGGDAACEKWVKEGLERRKNAEQAYRGRAGAGAGGGDGDGDVDMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1RE18</accession>
    <name>I1RE18_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG01890.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T04569</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317739.1">
        <property type="nucleotide sequence ID" value="XM_011319437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RE18"/>
    <dbReference type="FunCoup" id="I1RE18">
        <property type="interactions" value="772"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RE18"/>
    <dbReference type="EnsemblFungi" id="CEF74091">
        <property type="protein sequence ID" value="CEF74091"/>
        <property type="gene ID" value="FGRRES_01890"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01890"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04569"/>
    <dbReference type="eggNOG" id="KOG0809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038177_0_0_1"/>
    <dbReference type="InParanoid" id="I1RE18"/>
    <dbReference type="OrthoDB" id="10251371at2759"/>
    <dbReference type="PHI-base" id="PHI:9155"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000021">
        <property type="entry name" value="SNARE complex subunit (Tlg2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="SYNTAXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="247"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="199"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF74091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="344" mass="38623" checksum="623A3313612FD481" modified="2012-06-13" version="1">MWRDRTNLYISYRQSYAHHPTQRRPYGPGASASGALADTYTSSYPNEDRLGLLSAGAFEDDGDAVIEMDVLPPRWAAFSDDITDLLADIATKGQRLEKLHQKHVLPGFNDEEAKKAEEAQIENLTQDITKGFHACHRCIQKIEQMVRDSQHAGTITRAEETMAKNIQTSLASRVQDASASFRKKQSAYLKKLRGMGGFGALSPGERSSTPQPGSYLDPSLQESDADRSFSQSTLQATQQQRVLHSNDTAIAQREREIEDIAQGIIELSDLFRDLQNMVIDQGTMLDRIDYNVERMNTDVKAADKELVVASGYQRRTTKRKIILLLILIIFGMIILLVIKPKKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>I1REE2</accession>
    <name>I1REE2_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="6">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG02030.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T04903</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317902.1">
        <property type="nucleotide sequence ID" value="XM_011319600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1REE2"/>
    <dbReference type="FunCoup" id="I1REE2">
        <property type="interactions" value="822"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1REE2"/>
    <dbReference type="EnsemblFungi" id="CEF74258">
        <property type="protein sequence ID" value="CEF74258"/>
        <property type="gene ID" value="FGRRES_02030"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02030"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04903"/>
    <dbReference type="eggNOG" id="KOG1255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052104_0_0_1"/>
    <dbReference type="InParanoid" id="I1REE2"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="9">
        <location>
            <begin position="34"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6 7">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="47"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF74258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="329" mass="34443" checksum="65ECF29F39126CB9" modified="2012-06-13" version="1">MQSITRATRASALKNVGRRAYSSSQYAKTINNLRINSDTKVIYQGFTGKQGTFHAEQAIEYGTKVVGGTNPKKAGQTHLGLPVFKNVSEAVKATGATATGLFVPPPLAAAGIEEALEAEIPLVVCITEGIPQHDMVRITDMLKTQDKTRLVGPNCPGIIAPEQCKIGIMPGFIHKRGRIGIVSRSGTLTYEAVNQTTQAGLGQSLVVGIGGDPFSGTNFIDCLKVFTEDPNTDGIIMIGEIGGSAEEDAAEFLKQANTVNGGKPVVSFIAGISAPPGRRMGHAGAIVSGGKGGADTKIKALEDAGVIVERSPAGLGKALYNEFVRRDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1RFP2</accession>
    <name>I1RFP2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG02524.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T06057</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318458.1">
        <property type="nucleotide sequence ID" value="XM_011320156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RFP2"/>
    <dbReference type="EnsemblFungi" id="CEF74833">
        <property type="protein sequence ID" value="CEF74833"/>
        <property type="gene ID" value="FGRRES_02524"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02524"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06057"/>
    <dbReference type="eggNOG" id="ENOG502RRXM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036511_0_0_1"/>
    <dbReference type="InParanoid" id="I1RFP2"/>
    <dbReference type="OrthoDB" id="3357271at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="Voltage-dependent anion channel"/>
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        <source>
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    </evidence>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
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            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321975.1">
        <property type="nucleotide sequence ID" value="XM_011323673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RIS4"/>
    <dbReference type="EnsemblFungi" id="CEF78573">
        <property type="protein sequence ID" value="CEF78573"/>
        <property type="gene ID" value="FGRRES_03718"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03718"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13539"/>
    <dbReference type="eggNOG" id="ENOG502SUBR">
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    <dbReference type="OrthoDB" id="4802432at2759"/>
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        <property type="component" value="Chromosome 2"/>
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        <source>
            <dbReference type="EMBL" id="CEF78573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="450" mass="52069" checksum="299FDDDD1E26AC25" modified="2012-06-13" version="1">MDTLPPEIIRNIVSHLIVAARKVPHINELCPITSLAPYASISQQWRDIVESITFRHLILNSRRLTEADCKNYLTPLRLSYVRYIWYDFEFPAHNLAVTTDPEDYDDQLVFNRSVRQLLEVLSRFPHRDEPVVGLEMFITPPKKFALRLLRHETKRSRERTEVLFGNVIPAYVELFEDWDKGIAEIPAVSYFRVEPGSQSILFSPSSMNRIASKMPRLSRVEWWLTDEENIDSITDITETSQRTMFSRTLEIIPTSVRSYALSYLRQPPRSAVDRVNSTVPPSTQDDIMSRSFYSFTQRIGLDDFYLLARVDSTILLPQQPRADALWPSIRRYNLELKEHLPSGECIAQLPSKGYVYDQKIMDRFAIAAATCAARMPKIEELNVIHHGRTQMGICFNTCSEDEPCLEFFGQPDVPEPSEETLAIWKKAVKTHGLKWDVNITSEMGKVYHFY</sequence>
</entry>
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    <accession>I1RJR8</accession>
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        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321537.1">
        <property type="nucleotide sequence ID" value="XM_011323235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJR8"/>
    <dbReference type="STRING" id="229533.I1RJR8"/>
    <dbReference type="EnsemblFungi" id="CEF79048">
        <property type="protein sequence ID" value="CEF79048"/>
        <property type="gene ID" value="FGRRES_04100"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04100"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14489"/>
    <dbReference type="eggNOG" id="ENOG502RZJF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068291_0_0_1"/>
    <dbReference type="InParanoid" id="I1RJR8"/>
    <dbReference type="OrthoDB" id="4217619at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF79048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="397" mass="43583" checksum="CBF0BD33499B677B" modified="2012-06-13" version="1">MSATVDLAGSSPNVTTRQTRSSTRQVLSSVASPLKRDQSQDSSSKKPPVGLIPSESFISRVPLPSENRDVLVSKRDWLTSHTISLPQDVVRSMNLNPDTYFNPVDATYVFAQADAGTAVCISPDGVLLTCAHCIAEKPSELTTMPWHVLISSGGNIVFTRVISWDPIRDLALLLIDQAQSPHRPFPHIRIASNPPKFNSKLLCIGHPGSDDLEAKDSTLKTGYDTLVLSEGSFRGLAEDQDPQNNSGIGALRHTCWTYWGHSGAGLFDRTTGSLVGVHSSWDEKTGMRRGIPLEAVVSFLEEFELSRREAFGGSWQCNTREYDFTIANIVSNSQQLPAYSLMQGKINKIRLVQIRAPLGLNIHLIQSNLLLPLIIINPSSLFCTVLCFAEINMQAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RKR6</accession>
    <name>I1RKR6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG04482.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T15409</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321113.1">
        <property type="nucleotide sequence ID" value="XM_011322811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RKR6"/>
    <dbReference type="STRING" id="229533.I1RKR6"/>
    <dbReference type="EnsemblFungi" id="CEF79506">
        <property type="protein sequence ID" value="CEF79506"/>
        <property type="gene ID" value="FGRRES_04482"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04482"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15409"/>
    <dbReference type="eggNOG" id="KOG3038">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023535_1_1_1"/>
    <dbReference type="InParanoid" id="I1RKR6"/>
    <dbReference type="OrthoDB" id="10265994at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047288">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="2">
        <location>
            <begin position="332"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF79506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="469" mass="52423" checksum="5CE99034B175E05A" modified="2012-06-13" version="1">MANREKPSRDELKNLQEDLGPYYQIPLKPRRSGTHSRENSFQESLRQSSNTPEPKRSSSKRQDPSSRDSTPNRPSKSRTKNHSRDITSDAGTPKRSSPGRSETNTPRPESVKPPERNNREMSQRNRSGRASNRNNGNSHGEEVQIWELCKSQMGEIVSGINAENDTLTELVTMDKQVGAMNTEKIPGDSLKEMEQLCRAGVKHSEANMSSLKNTIEQLKVLRAVVHAKEQQDAQAAGPGKRQSRDTTAAASSLYDFDGVGDSPVPSPIGGNSRKYGDRARERERERERERERERERDRDRDRGDRDSMPPKADSVEPQGSVGSGVGSGNNKSKVVFQKGDSVAFKPKQLSSGDSLPDWILGEVAQVMGEGKSRRYKVLDIEPEDQSKQKEYRSSASSMIPITPESLAATLKDWESGKVVLALYPNTTTFYKAEVHSMDNDGKVNLKFEGENDSSTLQQVERRFVIEYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1RKT3</accession>
    <accession>A0A098DKQ6</accession>
    <name>I1RKT3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG04500.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T15453</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321093.1">
        <property type="nucleotide sequence ID" value="XM_011322791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RKT3"/>
    <dbReference type="EnsemblFungi" id="CEF79528">
        <property type="protein sequence ID" value="CEF79528"/>
        <property type="gene ID" value="FGRRES_04500"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04500"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15453"/>
    <dbReference type="eggNOG" id="ENOG502RSIA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_23_0_1"/>
    <dbReference type="InParanoid" id="I1RKT3"/>
    <dbReference type="OrthoDB" id="3897607at2759"/>
    <dbReference type="PHI-base" id="PHI:5812"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="24"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF79528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="329" mass="35484" checksum="35C0363226238516" modified="2012-06-13" version="1">MCIRDTYYPLLIACLVVGGIAVGLRLWVRIVKKAIGYDDVVMLLSLAGFIIFCAMELQAIRYGVGATVMEDGFDPTKAAIFFTIAQIAYILTTGLSKLGVGLVLFRLASGANMRGVRIILIISMIIVTLWFLVITLIFGLQCRPLSVGWGVGEGACLSTSALGTTGLALSGMDVTVSWFYALLSVCMLYKTQLRLKIKIMIMVLLGLGAVSSIAIIVRIKYLVDSSRLTWASESLTTQDSVEITLEGTVYSILEIALSILAASLTALRPLLMKIPGLRGDPSRRVGLGSVITFGHGGDIKIPSYCLDDRDISVIDSQEHIVPERPLTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1RKZ2</accession>
    <accession>A0A098DKX0</accession>
    <name>I1RKZ2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG04565.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T15597</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321020.1">
        <property type="nucleotide sequence ID" value="XM_011322718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RKZ2"/>
    <dbReference type="STRING" id="229533.I1RKZ2"/>
    <dbReference type="EnsemblFungi" id="CEF79598">
        <property type="protein sequence ID" value="CEF79598"/>
        <property type="gene ID" value="FGRRES_04565"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04565"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15597"/>
    <dbReference type="eggNOG" id="ENOG502SQKW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_0_1_1"/>
    <dbReference type="InParanoid" id="I1RKZ2"/>
    <dbReference type="OrthoDB" id="3477286at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="93"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF79598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="517" mass="59142" checksum="B18C82756FEDB69B" modified="2012-06-13" version="1">MNAATPSTKAATRKLPGHDIFCTPENSDFVSQVPYQSLSTTEREIRLLKILPDSGSGFVECELLPTVKLADVEKQYLALSYCAGSARNTRPIKICINQFDLAERSHQVGFMRDIYEKSRHTLICLSTPEAHGEDMRWLVMRRLDLELERVSWRHFYSDHHKTELGFEERWAASLGVAKSPWWTRAWVFQEFIVSTQATFLYGRHSMSYLDFAILTAGIPGPETPPPGFIVVTLNSHFQKEKTESTMSKMRGFLIAKLKQSRTTDLKVLLSCTKNCQATDKRDKIYSILGLAEPGYGIVPDYSGNIAINDLVVETTKKIILFEDSLMVLSYLDRDKIFYRYPRGTLPSWAIDWTDSASFGLRSSISVVSDYAFPRFVSYQPDGITQSSLDAVFMKLPHPQYPPNTQITAIQVWAVLLDDGFYKNGDSWYTFQGSRGFVIRGWDWDGLEVNSDYELWAVRGTIEPFLLCKYSYGYRIVRPVYCGNLARKLLPPDDQHRAEFYDGTFDMGKMEQTRIILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1RLJ5</accession>
    <accession>A0A098E112</accession>
    <name>I1RLJ5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG04798.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T16337</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323244.1">
        <property type="nucleotide sequence ID" value="XM_011324942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RLJ5"/>
    <dbReference type="EnsemblFungi" id="CEF87780">
        <property type="protein sequence ID" value="CEF87780"/>
        <property type="gene ID" value="FGRRES_04798"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04798"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16337"/>
    <dbReference type="eggNOG" id="ENOG502SN2K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025889_0_0_1"/>
    <dbReference type="InParanoid" id="I1RLJ5"/>
    <dbReference type="OrthoDB" id="3693942at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF87780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="613" mass="66486" checksum="16853867F0135CA7" modified="2012-06-13" version="1">MCSILRASNRPASWTLDQPDSFVETEEFVNSCEFRTSNITTSEFSSTGFQKVSETSTENIELALSGASILPDANMTHSIVKIEARFENNVTGVSVQKFSTGLLVNPDLVVTGSEAVFDDEYHLGTAKQVTCYLGYRSRGSSDSQRRYGQRVVFSADWAEDSGRRSRDIAFIQLAQAPAEAAPVQEEPVEQVPAPVAAPTEYVSDETQVPEPIAQPEPEPVVEQVEAPAPVCVEPVVEEPKFDFPAPAVEPVSEPASEKDYVEVQVVDETPDTSVAEETDPFYETIKTISQIDTKTLNIESSLIDDVGQFVSVAAGALVHHVTGAEAIMSGKSTKLAGISERALLAEASLQAVLAIEQSDELDYIIANMKQNWTANAPQVDQLSVLLAPYLSEAARCIIEYYQEDDIAQAATAKSSKRRNLGLRQFPTQENTKAFVKGIFGPTLLLSGRQDVFSSLGPVLRSAVSAVEQIVCEAGKTAVSEVTPKLLEKYKGAAPAPGDVQATRVLVERAIMADVAYQALSTLSQEKLQALKVIPLDNEIPQCDNVFDLIKYIIQMIGPVCLHDAKQAIHKFFPLLLDPVNTVKPTVVAPMKTGSSKLALRDFLSSKKGSVKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1RLN1</accession>
    <accession>A0A098DZB0</accession>
    <name>I1RLN1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG04841.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T16453</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323298.1">
        <property type="nucleotide sequence ID" value="XM_011324996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RLN1"/>
    <dbReference type="STRING" id="229533.I1RLN1"/>
    <dbReference type="EnsemblFungi" id="CEF86682">
        <property type="protein sequence ID" value="CEF86682"/>
        <property type="gene ID" value="FGRRES_04841"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04841"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16453"/>
    <dbReference type="eggNOG" id="ENOG502RMAT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089371_0_0_1"/>
    <dbReference type="InParanoid" id="I1RLN1"/>
    <dbReference type="OrthoDB" id="5092547at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124368" evidence="1">
        <location>
            <begin position="22"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF86682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="273" mass="28779" checksum="0BCB5A9C0EF2F0B8" modified="2012-06-13" version="1">MVRFSVLPAAAVTLFLCAVQAGPCRPLTTGVTSIAEGSSTVVPDSTATTLDTTAVTTLIDATTTVQEESTATTETSVAESLSTIASDTTIASVGVTTTTTALADLTTTAEVESTTTTAAPACVETQLFTNPGFDNSDNDIAPWTNDKGAITQTSPQSGSNALSFNRLENSSDDFGVSQTLSNLYGTYEFSYYYRFVTISQFADYTCDIHLKVGDASLRGSFEDNVGGWKYGSVTFNDLNVAQADVQLIANCGGEYHQILVNLDSLAFTRVCSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1RLV7</accession>
    <name>I1RLV7_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG04927.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T16657</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323398.1">
        <property type="nucleotide sequence ID" value="XM_011325096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RLV7"/>
    <dbReference type="SMR" id="I1RLV7"/>
    <dbReference type="STRING" id="229533.I1RLV7"/>
    <dbReference type="EnsemblFungi" id="CEF88815">
        <property type="protein sequence ID" value="CEF88815"/>
        <property type="gene ID" value="FGRRES_04927"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04927"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16657"/>
    <dbReference type="eggNOG" id="ENOG502SDUV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113403_0_0_1"/>
    <dbReference type="InParanoid" id="I1RLV7"/>
    <dbReference type="OrthoDB" id="6224010at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF5">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF88815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="153" mass="17869" checksum="27723AC198D0B584" modified="2012-06-13" version="1">MATQNPPMPQEKLGVPSRNPLPLSASQEAQVRDIFYQKVRKECADEIKAFAACALGRTFTVSFACRAEHRVMNNCMKIHATQAAHDEAREEWFALRIERQKEREKKARVAQAQEDFMREWWGLPEHVRLSRQKEMEKRGERIHGLAARDRPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1RN94</accession>
    <accession>A0A098E4E1</accession>
    <name>I1RN94_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG05460.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T17965</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323999.1">
        <property type="nucleotide sequence ID" value="XM_011325697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RN94"/>
    <dbReference type="EnsemblFungi" id="CEF88472">
        <property type="protein sequence ID" value="CEF88472"/>
        <property type="gene ID" value="FGRRES_05460"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05460"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17965"/>
    <dbReference type="eggNOG" id="ENOG502S8PK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043185_0_0_1"/>
    <dbReference type="InParanoid" id="I1RN94"/>
    <dbReference type="OrthoDB" id="2555634at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018800">
        <property type="entry name" value="PRCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621:SF2">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10253">
        <property type="entry name" value="PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF88472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="375" mass="40266" checksum="FB59D0CE88D23DCC" modified="2012-06-13" version="1">MGLVDYSDSEGSGSEAEVQLPVKTAPKQTASSKKPFQKVVDRSNPGKIVVSLPQLTDDKAQSQEPTEKKIKTGGGGRFSGFNSFLPAPKKANIPKPAASSSAYTRPAFQFKTSAAPGFSRDSGDDQKTSNDDASENVRGPAQKAAAQPHIPEGQKPADEVKLVGKPLMFKPLSVARNPQKKKKLNSGMAKPILTPHTESKQAEAAAPKKVSLFSMHTEEPSEPTEKTSTGVYEPMFATTESSLAYDKGAYGDYASHAQAGPSATTLPGSESLDTVVEDLNLTPAQQRELFGRNGLGNQAAKKVINFNMDKEYRHNEEIRAAGEEQTHNPVRAIQGGGKHSLRQLVQNAQSQRDALEDSFAKGKSNRKEAAGKYGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>I1RNF9</accession>
    <name>I1RNF9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG05535.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T18151</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF85871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324083.1">
        <property type="nucleotide sequence ID" value="XM_011325781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RNF9"/>
    <dbReference type="SMR" id="I1RNF9"/>
    <dbReference type="FunCoup" id="I1RNF9">
        <property type="interactions" value="489"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RNF9"/>
    <dbReference type="EnsemblFungi" id="CEF85871">
        <property type="protein sequence ID" value="CEF85871"/>
        <property type="gene ID" value="FGRRES_05535"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05535"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18151"/>
    <dbReference type="eggNOG" id="KOG0082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014184_6_0_1"/>
    <dbReference type="InParanoid" id="I1RNF9"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="PHI-base" id="PHI:1012"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000051">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="150"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="175"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="269"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF85871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="353" mass="41024" checksum="D763C1919E8B50E7" modified="2012-06-13" version="1">MGCGMSTEEKEGKARNEEIENQLKRDKMMQRNEIKMLLLGAGESGKSTILKQMKLIHEGGYSRDERESFKEIIFSNTVQSMRVILEAMESLELPLEDQRMEYHVQTIFMQPAQIEGDVLPPEVGSAIEALWKDRGVQECFKRSREYQLNDSARYYFDNIARIAAPDYMPNDQDVLRSRVKTTGITETTFIIGDLTYRMFDVGGQRSERKKWIHCFENVTTILFLVAISEYDQLLFEDETVNRMQEALTLFDSICNSRWFIKTSIILFLNKIDRFKEKLPVSPMKNYFPDYEGGDDYAAACDYILNRFVSLNQHETKQIYTHFTCATDTTQIRFVMAAVNDIIIQENLRLCGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1RNM6</accession>
    <accession>A0A098DXQ8</accession>
    <name>I1RNM6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG05609.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T18323</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324169.1">
        <property type="nucleotide sequence ID" value="XM_011325867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RNM6"/>
    <dbReference type="EnsemblFungi" id="CEF86117">
        <property type="protein sequence ID" value="CEF86117"/>
        <property type="gene ID" value="FGRRES_05609"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05609"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18323"/>
    <dbReference type="eggNOG" id="ENOG502TJM9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2038204_0_0_1"/>
    <dbReference type="InParanoid" id="I1RNM6"/>
    <dbReference type="OrthoDB" id="3924764at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124419" evidence="1">
        <location>
            <begin position="19"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF86117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="121" mass="12552" checksum="1110F425904EDD28" modified="2012-06-13" version="1">MLSKAIIAAITLVGLAAAAPLSSYDPCPTICQDGVNDCGESWGGCWDICKSEESPTPPPCTATYTPTIPTITSDPPITLPVITPDPTITLSIITPDPTITLPIITGDGEFTTAVPTPRLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1RNZ9</accession>
    <accession>A0A098E2Y2</accession>
    <name>I1RNZ9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG05746.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T18663</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324328.1">
        <property type="nucleotide sequence ID" value="XM_011326026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RNZ9"/>
    <dbReference type="STRING" id="229533.I1RNZ9"/>
    <dbReference type="EnsemblFungi" id="CEF87448">
        <property type="protein sequence ID" value="CEF87448"/>
        <property type="gene ID" value="FGRRES_05746"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05746"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18663"/>
    <dbReference type="eggNOG" id="ENOG502QUFU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057752_3_0_1"/>
    <dbReference type="InParanoid" id="I1RNZ9"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF87448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="293" mass="33040" checksum="5C64C9BE8CC92121" modified="2012-06-13" version="1">MEGSSGARGDAEHHLIEELCASSTLASFYNLLHDGENADIIIVCGNREFKAHRAVKRIIRKTELKGVDPDVFQRFLEFLYTGTYTVDGDTSRFLTTPSITADIESLLKDYPGWHKASSETTAPDSPKRPVRRSSRLNSTAESMDETPDPDSMMTTESPMATGTTPNSSLPPESREAPFKTPFPPVMAMSLELYNLASEYNVPALQLLALERFHIAAKDRWIPSWGGATWDDTKEFEDVVLDLYKIRDDQPMWKVMILLIKSKASTGDDVLKRRMREVVKEHHDLVECRELVCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQ23</accession>
    <name>I1RQ23_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Signal recognition particle subunit SRP68</fullName>
            <shortName evidence="10">SRP68</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG06156.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T19627</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SRP68 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324789.1">
        <property type="nucleotide sequence ID" value="XM_011326487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQ23"/>
    <dbReference type="FunCoup" id="I1RQ23">
        <property type="interactions" value="946"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RQ23"/>
    <dbReference type="EnsemblFungi" id="CEF87609">
        <property type="protein sequence ID" value="CEF87609"/>
        <property type="gene ID" value="FGRRES_06156"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06156"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19627"/>
    <dbReference type="eggNOG" id="KOG2460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018649_2_0_1"/>
    <dbReference type="InParanoid" id="I1RQ23"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="587"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF87609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="621" mass="67720" checksum="3F7319F8B6A207CA" modified="2012-06-13" version="1">MDITKFVVQGRDQSLLYGDYSTYHKHCTKRVQSCRRKLGIATKNRGKFRDHDKVTAEQIAQNHEYVHLLLLASERSWAQTMAMKASRATDTRGITGRTRSHITSRLVKATSAADALVEALSQTDVSGASQTDLLEATAYARLIRGSSGFEKKSWEASLQNYAAARVIYSALASATTGDLYKDLLTETIDPSIRYAAYQLKTPRTVPIPIIARKTFPQSDAFLVDQINEIDPTILKSDEAKAKDGIASAEGAPKTLTWRSREVNIEDAQIAMAWGAVLAAKERLAANLAEPKGRGPYELAGAYDEILMLSQDAVDATKQAIDEMRAEGVEQGDARMQSLQITRTAVNFETISWRIGRSRVLTGEHDGALDQYGSPKKGKGKAAQEDVREKDIPTGKKLTKLKEKVALYDGILQNIKSITELPGVANDQGLAGQIAAYVKYFEALKALAIARSHATAGNPAAALALISHADGLVEESQSNVPASDGSSNKTPLNLSVSAEDVEYLQNLLNGELQRHRAIVHVENLRKNHGLSTSDAVKRPLIETQNQYPSGGVNLDHIVEFPPKISTIPVKPIFLDVAWNYIDYAGKASPKQAPTAAKPEAPKTEESSAPQQAKRGWFGFGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQ80</accession>
    <name>I1RQ80_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T19789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324864.1">
        <property type="nucleotide sequence ID" value="XM_011326562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQ80"/>
    <dbReference type="SMR" id="I1RQ80"/>
    <dbReference type="STRING" id="229533.I1RQ80"/>
    <dbReference type="KEGG" id="fgr:FGSG_06219"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19789"/>
    <dbReference type="eggNOG" id="KOG1036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038526_0_0_1"/>
    <dbReference type="InParanoid" id="I1RQ80"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="255"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SCB64890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="348" mass="37200" checksum="E93B4E076DDD4C4E" modified="2012-06-13" version="1">MAPATQYELSPSPTDAVSSIAFAPSSGTKLLVSSWDKKVYCYDIAGGAGETTLINTYEHRAPVLDVCFGANDNEAFTAGMDWAVNKIDLETGEKTQLSKHAAPVRSIAYSPTFSILVSASWDCSLNLHNLNDPSSTPIRVSLPGKPHALAASPTKIVVAMAGRVINIYDLKTIADLFATGSSDLQPWQQRESSLRYLTRAVSCMPNDAGYATSSIEGRVAVEWFEDTPESQARKYAFKCHRQAAPDGDGDIVYPVNALAFHPVHGTFASGGGDGTAALWDAEAKRRLKQYQKFPNSVAALSFSSDGKYLAVGVCPGFETGQEDYSGAGQTSVLIRELGENEAKGKGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQI4</accession>
    <accession>A0A098DWZ8</accession>
    <name>I1RQI4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG06328.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T20049</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XFP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF85872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324985.1">
        <property type="nucleotide sequence ID" value="XM_011326683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQI4"/>
    <dbReference type="STRING" id="229533.I1RQI4"/>
    <dbReference type="EnsemblFungi" id="CEF85872">
        <property type="protein sequence ID" value="CEF85872"/>
        <property type="gene ID" value="FGRRES_06328"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06328"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20049"/>
    <dbReference type="eggNOG" id="ENOG502QUUF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013954_2_0_1"/>
    <dbReference type="InParanoid" id="I1RQI4"/>
    <dbReference type="OrthoDB" id="2532903at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02011">
        <property type="entry name" value="TPP_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01403">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023962">
        <property type="entry name" value="Phosphoketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
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        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003617">
        <property type="entry name" value="PRK05261.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003619">
        <property type="entry name" value="PRK05261.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273:SF0">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal" evidence="6">
        <location>
            <begin position="23"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal" evidence="5">
        <location>
            <begin position="602"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF85872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="819" mass="91990" checksum="DAB830E2BF2966BA" modified="2012-06-13" version="1">MSPEVKSISPFGIARSTVQGEPLSKEEIQQYNDFFKASCYLSLGMIYLKENPLLRQPLKAEHLKLRLLGHFGSAPGQIFTYMHFNRLIIKHDLHALFISGPGHGAPAVLSQSYLEGVYTEVYPDKTLDDEGMQKFFKSFSFPGGIGSHATPETPGSLHEGGELGYSISHAFGAVFDNPDLIALTMVGDGEAETGPLATAWHSNKFLNPIVDGAVLPVLHLNGYKINNPTVLARISHRELECLFIGYGWQPYFVEGDDIESMHQAMAATLEHCVDEIRKIQKEARDSGEAVRPLWPMIVLRSPKGWTAPRKVDNNYLEGYWRAHQVPIADPATNPAHLKVLEDWMRSYEPERLFDANGAPIASLRALIPQGNRRMSANPVANGGLLRKPLKMPDFRDYAIKVESPGNVMNASMTNMAVFLRDVMATNQTNFRLFGPDETESNKLGGVYDAGKKVWMGEYFEEDDNGGNLAKAGRVVEMLSEHNCEGWLEGYLLSGRHGLLNSYEPFIHVIDSMVNQHCKWIEKCLEVEWRAKIASLNILLTAVVWRQDHNGFTHQDPGFLDVVANKSPEVVRIYLPPDGNCLLSVMDHCLRSVNYVNVVVSDKQEHLQYLPMDAAIEHCTKGIGIWPQFSTDAGQNPDLVMASCGDISTHESLAAIDLLLEHFPDLKIRCVNVVDLFKLIHPSDHPHGLTDSEWTSLFTDDTPVIFNFHSYPWMVHRLTYKRPGSRNLHVRGYKEKGNIDTPLELAIRNQTDRFSLAIDAIDWMPQLRNRGASARQALLNSQIQARNEAFETGMDPAFLKNWTWKRNGLWKKVSEGLASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RRD0</accession>
    <name>I1RRD0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG06649.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T22827</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326275.1">
        <property type="nucleotide sequence ID" value="XM_011327973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RRD0"/>
    <dbReference type="FunCoup" id="I1RRD0">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RRD0"/>
    <dbReference type="EnsemblFungi" id="CEF83872">
        <property type="protein sequence ID" value="CEF83872"/>
        <property type="gene ID" value="FGRRES_06649"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06649"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22827"/>
    <dbReference type="eggNOG" id="KOG4499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036110_3_0_1"/>
    <dbReference type="InParanoid" id="I1RRD0"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="4">
        <location>
            <begin position="21"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF83872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="301" mass="33509" checksum="514A658484BCFF68" modified="2012-06-13" version="1">MGADIQQWTIEKPWLETHCLLGEGPFYEKSVDTLRFVDIRNKRLHYVKVTEGPSSLKTVQLDVCPTVTANIAGVDPQERIALGVKYGLAIFDVKKETYELIQPFEEPANERLRSNDGGVDPLGRFWLGTMTDFGLGPFKPEGAVYLMDSKSREVKLPDMTIPNTPGWSPDGKTLYITHSSAREVFAFDFDTESGEISNKRVFYTHNGSGEPDGFRVDVDGFIWHAVYGEGRVIRIDPKTAEIVGEVKVPTKNTTCVQFVGTELVITTAADDEGEGTSREYGGHVFKVDVGIQGLELHEFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1RSY4</accession>
    <accession>A0A098DWC3</accession>
    <name>I1RSY4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG07271.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T24393</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327012.1">
        <property type="nucleotide sequence ID" value="XM_011328710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RSY4"/>
    <dbReference type="STRING" id="229533.I1RSY4"/>
    <dbReference type="EnsemblFungi" id="CEF85173">
        <property type="protein sequence ID" value="CEF85173"/>
        <property type="gene ID" value="FGRRES_07271"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07271"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24393"/>
    <dbReference type="eggNOG" id="ENOG502RXR7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025640_2_1_1"/>
    <dbReference type="InParanoid" id="I1RSY4"/>
    <dbReference type="OrthoDB" id="5422510at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032:SF1">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF85173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="487" mass="53465" checksum="A92A415D2EA85D0E" modified="2012-06-13" version="1">MADENTTSNSSGRPAAGVSSGFNAPPSGQGPRRAMTVSVAEEAASASRRQYPASPSFDSIPPRRSSNFSEYSLNEARDFLNPQPRDPGNADSSLAGESSSLPSLSLAFAFLPAISGLLFKNGSAVVTDFMLLGLAGVFLNWSVTQPWTWYHSAQQVRIQHEVVADSVIDDDSDLDSSTHGPGPNSPLDHVPEDEAVHAEPTEEIHEREPSKQQQDALAELYFYEIIALASCFLLPLLGAYLLHAIRSQLSRPSEGLVSNYNLTIFLLMAEFRALSHVIKLVQSRTLHLQRVVQGGPSKFQQVNKNTEQLETVLARLERLESRVTNDETSTVQDIKQEISKTKQKDSAVARDVRNAIQPELDALNRAVRRYEKKATLLQIQTESRFSGVEARLDDAIALAASAAKNSASHKNVFVWAMESLTAAFLLPFRTLLRIMLLPLSTIFALMSKGKKRNSPPVKSSSRSSRNGKTVVQPKYNGDRVPSRVAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1RUD3</accession>
    <accession>A0A098DP53</accession>
    <name>I1RUD3_GIBZE</name>
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        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">FGRAMPH1_01T25755</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327647.1">
        <property type="nucleotide sequence ID" value="XM_011329345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RUD3"/>
    <dbReference type="STRING" id="229533.I1RUD3"/>
    <dbReference type="EnsemblFungi" id="CEF83641">
        <property type="protein sequence ID" value="CEF83641"/>
        <property type="gene ID" value="FGRRES_07822"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07822"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25755"/>
    <dbReference type="eggNOG" id="ENOG502SW3V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065409_0_0_1"/>
    <dbReference type="InParanoid" id="I1RUD3"/>
    <dbReference type="OrthoDB" id="5426604at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF83641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="294" mass="31988" checksum="F26F1B62F7D629B7" modified="2012-06-13" version="1">MAPISVLLNSNVTDDKGLQVFYVTSQDNLGVALRNSAAKGVDSQDFYEAAADAHVGLIPVKSEIGSAVMNGLNLVVAITKHKLKDECEKPTLNDVSIVSPVYQVLDTTGITNTTAAIVSNEDNSNAWVYYLKGSDPKEIQICEYELTTGNIGPISNLNIDPDCSLGAFYDTNGNGRSIIYQDKDQGHIKEYQIESGQTIDIGDSAGAKLNTSLAVAYFEGYAYLYYTDQFMNLYRIIKDKNASKWGEHKKITPGANPDPSSQLTAIGANGTIHLFYQAQGNKKITHFREKAVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RVX2</accession>
    <name>I1RVX2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG08419.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T09913</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320355.1">
        <property type="nucleotide sequence ID" value="XM_011322053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RVX2"/>
    <dbReference type="STRING" id="229533.I1RVX2"/>
    <dbReference type="EnsemblFungi" id="CEF76759">
        <property type="protein sequence ID" value="CEF76759"/>
        <property type="gene ID" value="FGRRES_08419"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08419"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09913"/>
    <dbReference type="eggNOG" id="ENOG502SJRE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_441481_0_0_1"/>
    <dbReference type="InParanoid" id="I1RVX2"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="236"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF76759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="629" mass="71860" checksum="30EB37CF749BA96A" modified="2012-06-13" version="1">MRLVNTKTLQLETLEEGSEKYAILSHTWGNDEVLFDDIQSPARMGEIRKKNGPAYRKIAQSCERAQSRELNYIWIDTCCIDKSSSAELSEAINSMFRWYSNSEVCYAYLSDVFIHEVGVEVADSLKSSRWFTRGWTLQELLAPNEVEFFDHNWSPLGERHALSSTISDITGIDETYLHKPDTKKDRRISIKLQRENVATRMGWMAQRETTRVEDIAYALMGIFGINMAVLYGEGSRAFLRLQEEILKRSPDQSILVWRWPLARKPETKTQRMHFLADSPANFNLRTYAGQEDSEKFGVRLTDQGLVVRVWKCPCKLTRWNHDKTELIDAGNRWLAVLDCSLSPDTLSRPAIILGESPYAEGVFRRDPTSVIMVIEHDRMKSGYLDTGGDRHAIHSIEYKPEFKTETILLESDTVEPEVRLRGSFPFKVNMTLKDRELKQRAAYTGSQRYVVAGQLGIKPTQNPIYGVIFLGDDETDTELVVWWGLIEEGSAMYDVHNRHNGPRVWSNSVPVCFAQSWKNLTGADTWDASLAESLAVNMLCEEFPLPWKGTERPSVVEVEDGLNLQNKIGDSKPMATETVIELFTQCSQPIIECVGWGMRLKASMRRVEFLGRLCCELDIEEKNPNVEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1RW93</accession>
    <name>I1RW93_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG08554.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T10249</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320199.1">
        <property type="nucleotide sequence ID" value="XM_011321897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RW93"/>
    <dbReference type="STRING" id="229533.I1RW93"/>
    <dbReference type="EnsemblFungi" id="CEF76928">
        <property type="protein sequence ID" value="CEF76928"/>
        <property type="gene ID" value="FGRRES_08554"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08554"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10249"/>
    <dbReference type="eggNOG" id="ENOG502S2Z9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101422_0_0_1"/>
    <dbReference type="InParanoid" id="I1RW93"/>
    <dbReference type="OrthoDB" id="3559948at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011942201" evidence="11">
        <location>
            <begin position="16"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="12">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="125"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF76928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="207" mass="19804" checksum="5C72F8DD3482F7E7" modified="2012-06-13" version="1">MKATLFLAAAGLAVAQDLSGQPECALKCLKEFIPKAGCELDNTACQCEASFQTKLAPIITPCLTEACQVDDLLKAQKAAADACKAYAATAGSGSATAAPTESLGSVTVSIDTSITGSASVPAIFSSIPDEKPIPPVTPRPGNGTMTKTMTEGGGSGGGAVTPTGTSGGGGGSGTTGGASSVPTDAGAGTAGPAAMGLLAIIAAAIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1RWD3</accession>
    <name>I1RWD3_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG08597.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T10343</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320153.1">
        <property type="nucleotide sequence ID" value="XM_011321851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RWD3"/>
    <dbReference type="STRING" id="229533.I1RWD3"/>
    <dbReference type="EnsemblFungi" id="CEF76975">
        <property type="protein sequence ID" value="CEF76975"/>
        <property type="gene ID" value="FGRRES_08597"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08597"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10343"/>
    <dbReference type="eggNOG" id="KOG0335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_5_1"/>
    <dbReference type="InParanoid" id="I1RWD3"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="165"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="388"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="554"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="579"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF76975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="620" mass="67285" checksum="F2701CAB8A28CD8E" modified="2012-06-13" version="1">MSDPWGTGDMSDALPATKEADAFPTTEQSTQAQNGDAQVEPPKGYDASRGRWTEPQAFDYTSLAAGSDTQTWGCSARAYAWQDEYGEVGPKCPDLELELFGEPDTRHERKGLDFSRIESIEVQQEGPTKIDPISSFKDGGIHPAMLENIELCGYDVPTPIQKFTIPSILTGHDVIGIAQTGSGKTAAYLIPILSKLMGKAKKLAATRPNPITFRPGMDEVTAEPLVLIVVPTRELALQIFNEARKLCYRTMLRPGVVYGGVPISEQISLLSMGCDILVGTPGRLVDFIQRPRNLTLRRLRYMVIDEADELLNDDWAEELNPILSGGEQDEGNVKFSLFSATFPKAARDLAKNYLAASHVRFRVGRAGSTTANIRQIVLQAEGHEKRELLVGLLEEMHGIRTIIFVNSRQSADNLDDFLFNMKLPVTSMHSDRTQQEREAAMRAFRSGNAPILIATGVTARGIDVQNVMHVINYDLPSIEYGGIEEYTHRIGRTGRIGHRGVATSFFSERDEPLGSVLTRTLLETDQEIPEFLQQYVPEGDARANLKFEADSDFDPNDYAGAGDAGGDAWGAGDGDDTGGGDAWGGDGGGDTGDTGGGDAWSRGGGDAWGAAPAPVAVDAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1RXB5</accession>
    <name>I1RXB5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T28219</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
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    <dbReference type="AlphaFoldDB" id="I1RXB5"/>
    <dbReference type="FunCoup" id="I1RXB5">
        <property type="interactions" value="527"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G28219"/>
    <dbReference type="eggNOG" id="KOG1673">
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    </evidence>
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        </source>
    </evidence>
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</entry>
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    <accession>I1RXI6</accession>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CEF83794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_011328739.1">
        <property type="nucleotide sequence ID" value="XM_011330437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RXI6"/>
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    <dbReference type="EnsemblFungi" id="CEF83794">
        <property type="protein sequence ID" value="CEF83794"/>
        <property type="gene ID" value="FGRRES_09056"/>
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    <dbReference type="eggNOG" id="ENOG502SJ0B">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 4"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF83794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="515" mass="58979" checksum="1C23A5C74F63E9AE" modified="2012-06-13" version="1">MSWHNRHPNLRPEDWDLLDFDQQQNEVFTITINGQSEDNSSPDTEHSVTPQTSRKVVEGEADLGQWVDKISDIQRKQNASTYQPGDNGSTINLILASQMSSLDELPFSQTAYSWIMTQMKIHGSIVRAINRNTQFYNCRTAGSWEGDMALSVTFFPNTLTTNAVWYGLDMKEHRTYGHSLTNADIITSRLTNFDGSCLHPLILPTMFAEFERERHIGMVRKYHTQLVQRINDLAYPSSSTNNSNETDLLRISTERKSRDSNFTERLRTLVSQLSMNSKTGHSSHVEDISAQEKTFHERPCKEKKEDPEPAVVLWQNTSFLSNGLLNWQTQLTKMLEQVQDLDDTQFGVSTSEYDPQVESKLARLRDVGLRIKTRIQDLIYEYDEHIRQCNHITEGLRLATQLELNDIGHKDARTNQEIARVNLKVAQMTRLDSSLMRSIATLGMIFLPATFVSTFFSMDFFQWSGEDGKNQELISSYFWVYIVVAIGLTVLTMSIFYTCVLRTPSVDVDEESTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1RY57</accession>
    <name>I1RY57_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG09294.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T27445</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328469.1">
        <property type="nucleotide sequence ID" value="XM_011330167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RY57"/>
    <dbReference type="STRING" id="229533.I1RY57"/>
    <dbReference type="EnsemblFungi" id="CEF84679">
        <property type="protein sequence ID" value="CEF84679"/>
        <property type="gene ID" value="FGRRES_09294"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09294"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27445"/>
    <dbReference type="eggNOG" id="KOG2620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_1_0_1"/>
    <dbReference type="InParanoid" id="I1RY57"/>
    <dbReference type="OrthoDB" id="434619at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08829">
        <property type="entry name" value="SPFH_paraslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="STML2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16200">
        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="68"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="366"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF84679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="400" mass="42857" checksum="D2891335051D6DDA" modified="2012-06-13" version="1">MAMSLARVALRAPQSQSRFAAAAATITARTIVAYGRHFSTTNQALIPSGFGSPIVPSYFSKPRLPANTVIRFVPQQTAWIVERMGKFNRILEPGLAVLVPFIDRIAYVKSLKEVAIEIPSQSAITADNVTLELDGVLFTRVFDAYKASYGVEDAEYAISQLAQTTMRSEIGQLTLDHVLKERAALNTNITAAINDAAEAWGVTCLRYEIRDIHAPGAVVEAMHRQVTAERSKRAEILESEGQRQSAINIAEGKKQSVILASEALRAERINEADGEAEAIRLKASATAQGIDAVSESIIRGDAGAQAAVSLRVAEKYVDAFGKLARESTAVVVPGNVGDISGMIATGLSVFGKVGQAQAQTMAKSLVEPKGDSQTAELEGQAKPDVKETVLESFNQATSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1RYT8</accession>
    <name>I1RYT8_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG09547.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T26829</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the complex I NDUFA8 subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="CEF84573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_011328169.1">
        <property type="nucleotide sequence ID" value="XM_011329867.1"/>
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    <dbReference type="AlphaFoldDB" id="I1RYT8"/>
    <dbReference type="SMR" id="I1RYT8"/>
    <dbReference type="STRING" id="229533.I1RYT8"/>
    <dbReference type="EnsemblFungi" id="CEF84573">
        <property type="protein sequence ID" value="CEF84573"/>
        <property type="gene ID" value="FGRRES_09547"/>
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    <dbReference type="KEGG" id="fgr:FGSG_09547"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26829"/>
    <dbReference type="eggNOG" id="KOG3458">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
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    <dbReference type="InterPro" id="IPR016680">
        <property type="entry name" value="NDUFA8"/>
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    <dbReference type="PANTHER" id="PTHR13344:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8"/>
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        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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            <begin position="91"/>
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            <dbReference type="ARBA" id="ARBA00022660"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="PIRNR" id="PIRNR017016"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF84573"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZJ1</accession>
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    <gene>
        <name evidence="3" type="primary">FG09837.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T26163</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327847.1">
        <property type="nucleotide sequence ID" value="XM_011329545.1"/>
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    <dbReference type="AlphaFoldDB" id="I1RZJ1"/>
    <dbReference type="STRING" id="229533.I1RZJ1"/>
    <dbReference type="EnsemblFungi" id="CEF85201">
        <property type="protein sequence ID" value="CEF85201"/>
        <property type="gene ID" value="FGRRES_09837"/>
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    <dbReference type="KEGG" id="fgr:FGSG_09837"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26163"/>
    <dbReference type="eggNOG" id="KOG2406">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_006241_2_0_1"/>
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    <dbReference type="OrthoDB" id="27237at2759"/>
    <dbReference type="PHI-base" id="PHI:1615"/>
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        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
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    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
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        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF85201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="634" mass="71892" checksum="A1D78BB36484D5FD" modified="2012-06-13" version="1">MSFRSAIIEEEEISQKSGQTEETEFKNHLPDNCVEYLLFYLDPQLDARKQLSQVENIRKSAIDLANTLTKDYIWQKDEFNLALKNESGLLYLHGITDYSDAVEDEWLIVYILRELSKSHPSLWIRVFDTDGEFLLVEAANVLPRWLNPEIDNNRTWINTGHLLLVPVKDEDGLKTRNLELPEAVEIIRAKREALVHSGFVEAEAFYRLEKYPAQISDSIHHSLVTIPRKLAHVLHSLPKSVAPAVETFYLRDPIALKRVISPSGPPVFPPQDLITTSVRFSKVLFAQLRSQRFDTPPRWADVLRKVQKEVSSGESDKVMARLDIGMKLTCGFEMLAAKADKSNNRVVRELAIVIEDLEEDGIDALPSDEEIKSWKDAERDDSEAWMDIDYQEFERELDGKRGNNTSNAKPGFGDANTQSDLRKIVSRFEAFLNDDSAGMDGAELDEMDYDDEDDDEFDDDSESEDKEVSFDEEEFAKMMREMMGLPSTDSNNNTPKKTKHKSESPVMDEEDEEIQKLTTEFEAELNEHGALKLDPAAEKQPCLKNISQKEGETSLPNIEEEGGEDSEEEVDIDYNLAKNLLESFKSQGGMAGPTGNLLGMMGFQLPRDEDEENDMNDEDEAGDSSSKGKRKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZQ3</accession>
    <accession>A0A098D9T6</accession>
    <name>I1RZQ3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG09905.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T06805</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318811.1">
        <property type="nucleotide sequence ID" value="XM_011320509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZQ3"/>
    <dbReference type="EnsemblFungi" id="CEF75207">
        <property type="protein sequence ID" value="CEF75207"/>
        <property type="gene ID" value="FGRRES_09905"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09905"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06805"/>
    <dbReference type="HOGENOM" id="CLU_2171313_0_0_1"/>
    <dbReference type="InParanoid" id="I1RZQ3"/>
    <dbReference type="PHI-base" id="PHI:1095"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF75207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="110" mass="11783" checksum="51653C53308D3426" modified="2012-06-13" version="1">MASQGKCNSVQGPLLLVGLDSTYPGQGGSRCPIPSVYRVTWRKQPVAELCGPIQLTESTMWSMLQSENVAIAGEQLCNIPKPHGILRRSMGSIGIQIPSNVMQFDPASGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZY1</accession>
    <name>I1RZY1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 11">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FGRAMPH1_01T07003</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 11"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318904.1">
        <property type="nucleotide sequence ID" value="XM_011320602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZY1"/>
    <dbReference type="FunCoup" id="I1RZY1">
        <property type="interactions" value="408"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RZY1"/>
    <dbReference type="KEGG" id="fgr:FGSG_09991"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07003"/>
    <dbReference type="eggNOG" id="KOG3754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010467_0_0_1"/>
    <dbReference type="InParanoid" id="I1RZY1"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="PHI-base" id="PHI:1602"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000001">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000004">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="519"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="682"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SCB64528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="717" mass="80983" checksum="3AB9BC35B59DA86A" modified="2012-06-13" version="1">MGLLALGTALDWPDAKKRAPQVREWGIKQLLEIWNKAKGKERDALLWGDEVEYLVVVYSEDNKRVLLSLRQAQILEALAADKDLKKQGGCVPELQEPTTTEKKTERTIPVFHPEFGRFMLEATPGKPWGIGFKELLDVEPDMKLRRKIAKEHMLSTEYPITLTTYPQIGVPGQFTDPYFPPSGPRLRSQFVPDEIANPHIRFPTLAANIRSRRGRKVQVNVPIFHDKNTPKPWKDPTVNLAKYDWPEDDDVRNGAAPDDFIHMDAMAFGMGSCCLQITFQAKNITEGRMLYDQLSPLGPIMLALTAATPVYKGFVANTDVRWNQISRAVDCRTPEELGEKPLTEGVRRIPKSRYASNSTYIAIDPRLRNEYLDPDLVYDSDIKRQLLEGGMDDRLATHFAHLFIRDPIVVFEEDLQELDLNKTDHFENIQSTNWQHMRFKPPPADNSIGWRVEFRSMEIQITDFENAAFSVFMVLVTRAILSFDLNFYIPIKKVDENMERAHEVDAVLKEKFYFRRNPFPSRPSRANTTFGDDSRPGSAHPSRPPSPGGPVEHEFEEMTVNDIINGSESGEFPGLIPIVESYLDSVNVDVSTRCHLSTYLDLISKRARGDLDTTARWIRNFIDIHPKYNHDSVVNDEINHDLIGAVIAIGERETAGRNFAGLGIHGLERLLNGFRGGCGGGSSNGSNGNSHAAETETVNGSLKRKSEWIDGQEVMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>I1S0F0</accession>
    <name>I1S0F0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG10174.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T07457</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319115.1">
        <property type="nucleotide sequence ID" value="XM_011320813.1"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1S0F0"/>
    <dbReference type="EnsemblFungi" id="CEF75533">
        <property type="protein sequence ID" value="CEF75533"/>
        <property type="gene ID" value="FGRRES_10174"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10174"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07457"/>
    <dbReference type="eggNOG" id="KOG0383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_18_0_1"/>
    <dbReference type="InParanoid" id="I1S0F0"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056616">
        <property type="entry name" value="Chromo_MIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055565">
        <property type="entry name" value="DUF7141"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041684">
        <property type="entry name" value="Znf-PHD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF17">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23615">
        <property type="entry name" value="Chromo_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23614">
        <property type="entry name" value="DUF7141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15446">
        <property type="entry name" value="zf-PHD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="786"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="1091"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="179"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="483"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="1363"/>
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        </location>
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            <begin position="1420"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
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            <begin position="1"/>
            <end position="11"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
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            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
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        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
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            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
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            <begin position="1377"/>
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            <end position="1437"/>
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        <location>
            <begin position="1455"/>
            <end position="1487"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF75533.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1588" mass="179856" checksum="F0E400955A6B2F23" modified="2012-06-13" version="1">METESMDHDPLQGHVDQDEDAIERSLELLRADLSEQHIPVDVAMMEVEQTLPNQDNDVREANEPDEKEEEILRIEGDISDEVKPPTKPSYRVQVVVPEISLEERAQYSFAHSHIVESVLGEAVHDTVEYRVEFTDGREELISFTQLVALDNGRAALARFNQGLGPLDFEIMAGTRKRKYAPEDDWDSEHESVISDQMDIDDEEDEEPFGTKRMRHSRLRSRENTKHLSRSPSKTDEDELDDLEPEPERPTRSLRVRQARQSTSASFKNRFGSQDQDELLGDVPPASEEEDDDFMPIVVSDINPKKGRPNKALQRLRRLQTKSMRQKALSQRPSRHKSNDSDIEFEAPRRSSRATRNTLNMQDDDLMDDESLYTVDDRTPGAPKIVSVREIFQPLSAESEFATMHMDTCQSCGGSRHRGQMIYCQGCTLSFHRSCIGPRSTREHMVTKVGEDSFVLQCKFCIKVPSKKDNNAPKHDMCQACKAPGSSCAPFSKKKTSRQEEKLREENDGVDPVTPVSPKLINNAGHVLFRCVECRRGWHVEHLPGARSGTIGTDLKSERLKDHSVDWRCKECATSRHKIHRLVAWRPARKDLAKQVPRPTYDQVREDDKEYLVKWDSRSYAHCVWKSGAWVYGKAAAKMRIAFSKRDAAEDLLKLNEQDAIPGEFLMPDIIFNVKADPSVRKGTREQEMNNLAHVTKIFVKFQGLGYDDVVWDSPPTDEDGEIYASFAEAYYEYVEGKYFSSESQNKIKERVKAFKAAPFEEINTQPAGLTRGKLMGYQIEGVNWLLGNYHSGRSVVLADEMGLGKTVQVVGLVTSLVQDSPKCWPFLIVVPNATCPNWRREFKQWVPELRVVAYHGGREPQALAYKYELFPNGSTDMKAHVVIMSYDSAQDPATKNLFKSINWAGLVVDEGQRLKNDQNLLYGALRSMRIPFRLLLTGTPLQNNKRELFNLLQFIDDKQNAAELDEEYEVLDKETLPKLHNKIRPYFLRRTKAGVLKFLPPMTQIILPVTMTVIQEKLSKSIMAKNPELIKAMFSNSKMNKKERGSLNNILMQLRKCLCHPFMYSEAIEERHHDPTVLQRNLVEASAKLLLLQVMLPKLQERGHRVLIFSQFLQQLDIIEDFLSGLGYDYRRLDGSIGSLEKQRRIDAFNAPESPVFAFLLSTRAGGVGINLATADTVIILDPDFNPHQDIQALSRAHRIGQKKKVLCFQLMTIDSVEERIMQIGKKKMALDHALIESMDDDELAGDDLESILKHGAQALFNDDYEKKSIHYDSAAVDALLDRTVENETKADDGTSFSYAKVWSNDKSGFEAGLATEEMAEPEAINSSVWDRILAQREAEAQRQAEANQEVLGRGNRRRQAINYKTEAAINPVPGDPEADSADSSDDFAGGDSGDESEEDASVPKGAETDAILELENPKARGKKGQQLHSQQVQNANKPRKETATGQQRQREWSTWKNGGPQNTNQQGYGQENRITIPSQNPYQQKGGQVIPGGSTDSARYTMGNHAYQGYNAPPVPHQRVVVTQSHPPPPDQIVNFRSDRLYSEAEVRLALDYVQHSNSDTCTKQKHRALLMDRLRSLTPESAVQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1S0W9</accession>
    <name>I1S0W9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG10360.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T07915</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319329.1">
        <property type="nucleotide sequence ID" value="XM_011321027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S0W9"/>
    <dbReference type="EnsemblFungi" id="CEF75761">
        <property type="protein sequence ID" value="CEF75761"/>
        <property type="gene ID" value="FGRRES_10360"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10360"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07915"/>
    <dbReference type="eggNOG" id="ENOG502SNWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036929_0_1_1"/>
    <dbReference type="InParanoid" id="I1S0W9"/>
    <dbReference type="OrthoDB" id="5305647at2759"/>
    <dbReference type="PHI-base" id="PHI:1418"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059009">
        <property type="entry name" value="Znf_C2H2_17_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059095">
        <property type="entry name" value="Znf_C2H2_17_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF24">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26177">
        <property type="entry name" value="zf_C2H2_17_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26176">
        <property type="entry name" value="zf_C2H2_17_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="211"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF75761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="335" mass="37272" checksum="6557F5BDBE6F623A" modified="2012-06-13" version="1">MSVAFEPRNFIHDGGYPPIGDDHDHDHTADQRFTDNDVAEQLSQYTTEASMLPDPTGVLGDDRGMMQDDTSVVHDATRLDLGHPAFPSPIDAAMPAPQIDGIPDDKDLSPSIDSPPPPRVRPIAKPEREAVKGVDGKFHCTQEDCQEEIRVFSRKCEWNKHMDKHERPYRCPAVGCENLPGFTYSGGLLRHEREVHNKHGGPKKTVNCPHLNCKRHTGKGFSRLENLNEHLRRVHTNPDGAGNTPPPDMVLSDENDSEQTGVKRKRRASDTANAEIIELKEEVKRLREENEKLTADVAQQSQHSLAMMAQIAELQDALRNGVSHHALGAPTAQMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1S1D4</accession>
    <accession>A0A098DAI5</accession>
    <name>I1S1D4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG10534.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T08349</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319528.1">
        <property type="nucleotide sequence ID" value="XM_011321226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S1D4"/>
    <dbReference type="STRING" id="229533.I1S1D4"/>
    <dbReference type="EnsemblFungi" id="CEF75978">
        <property type="protein sequence ID" value="CEF75978"/>
        <property type="gene ID" value="FGRRES_10534"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10534"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08349"/>
    <dbReference type="eggNOG" id="KOG1404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_4_0_1"/>
    <dbReference type="InParanoid" id="I1S1D4"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005685">
        <property type="entry name" value="PRK07483.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF1">
        <property type="entry name" value="AMINOTRANSFERASE CLASS-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF75978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="455" mass="49210" checksum="5049FF67D2A1D373" modified="2012-06-13" version="1">MDDLHLAPEPHLMHRSLLTRPEAVSSASGVYLNLSSGRKILDGCAGAAVAIIGHGSTEVQDAVVAQASQVSYVHTLTYTTSSAEELADHLLENEPFGLTRAYLVCSGSEAMDSAMKLARQYHVENGQPERTRFVSRRQAYHGNTVGAMSVGSHLARRAPYEGAILLDNVSHVSAAYEYRTKKDGETEEEYSKRLVDELEAEFLSVGPEKIMAFIAETVGGATAGCITPPAGYFSGVSKVCKKYGILLILDEIMCGVGRCGTFFAFEQDGDVQPDMVTIGKGLGGGYMPIAATLVHKGIIETLKKGTASFNHGHTYQAHPVSCAAALAIQKIIRRDNLVSRCATLGERLHKSLVETFKDAEFVGNIRGRGLFWGIEFVQDKKTKMPFDSKIRFGVKVQERAFELGLAVYPGMGTADGLVGDHVIVSPPLTITEEEMDVLVGLLKRAYDDVASKYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>I1S2E8</accession>
    <name>I1S2E8_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG10940.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T20849</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325435.1">
        <property type="nucleotide sequence ID" value="XM_011327133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S2E8"/>
    <dbReference type="FunCoup" id="I1S2E8">
        <property type="interactions" value="1419"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1S2E8"/>
    <dbReference type="EnsemblFungi" id="CEF87397">
        <property type="protein sequence ID" value="CEF87397"/>
        <property type="gene ID" value="FGRRES_10940"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10940"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20849"/>
    <dbReference type="eggNOG" id="KOG2573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015495_4_0_1"/>
    <dbReference type="InParanoid" id="I1S2E8"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
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    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="7">
        <location>
            <begin position="302"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="437"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="461"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="478"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF87397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="508" mass="56189" checksum="D010D000E8D30550" modified="2012-06-13" version="1">MSHIDYALYESPVGYAIFKVVHQQDAVGLKLKETQAATNDLAKFGKMVQLTNFSPFRGHVEALENINLVTEGIVSDYLKSVLELNLPQTSGKKTKVVLGVSEKNLAGAIKAQFPGLECETADTSDIVGDVIRGIRLHADKLLGGLKYGDVEKAGLGMGHAYSRAKVKFSVTRNDNHIIQASATIDFQDKGVNQFYMRVREWYGWHFPELVKIVSDNYTYCKLVLAIGDKKSLNDDKLHDIAALVEEDGEKAQAIIDAAKVSMGLDIAEADFEVINSFAEAVVKQADNRKSTNLYLEKKMGDIAPNLQTLIGTPVAARLISHAGSLTNLSKYPASTLQILGAEKALFRALKTKSNTPKYGLIYHSSFIGKAGVRNKGRISRYLANKCSMASRIDNFSEEPSTRFGEALKQQVEDRLEFYATGKKPAKNADVMKDVMDIMDGGDDAGSDEEMVDAPVVEKKSKKEKKEKKEKKDKKEKKRKLDEEAPVEKEADGEKKKKKKRKSKAADDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1S3Q3</accession>
    <accession>A0A098E139</accession>
    <name>I1S3Q3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG11446.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T22083</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325775.1">
        <property type="nucleotide sequence ID" value="XM_011327473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S3Q3"/>
    <dbReference type="EnsemblFungi" id="CEF86803">
        <property type="protein sequence ID" value="CEF86803"/>
        <property type="gene ID" value="FGRRES_11446"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11446"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22083"/>
    <dbReference type="eggNOG" id="ENOG502QXBB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029266_0_0_1"/>
    <dbReference type="InParanoid" id="I1S3Q3"/>
    <dbReference type="OrthoDB" id="3592035at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048527">
        <property type="entry name" value="Sde182_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011483">
        <property type="entry name" value="Sde182_NH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21027">
        <property type="entry name" value="Sde0182_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07632">
        <property type="entry name" value="Sde182_NH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124739" evidence="1">
        <location>
            <begin position="23"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulose-binding Sde182 nucleoside hydrolase-like" evidence="2">
        <location>
            <begin position="43"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulose-binding Sde182 C-terminal" evidence="3">
        <location>
            <begin position="391"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF86803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="513" mass="57440" checksum="4FA13D3D4E542A28" modified="2012-06-13" version="1">MELSIFQLVSALLWLQACLVAAIPGPHGSTTDLTTLPKVNRVRTFILTDILNEPDDTMSLIRYLLYSNEFDTRGIVAVTSWSLRNATHPGEIKRVIDVYGKVVEKLNQHVHPDNPYPHPRDLISKISSGPISYGRAALKQPLSEGAQNLVKALRESKEPLYLSLWGGANTLAQALQHIDKTETKRVASQLRSRLRVYAISDQDDAGAYIRVKWPDVFYIVNVHGYREYSLGTWTGISTGDNNAANRTKVLDDWLTPNIRIGPLGSEYPKIIYTMEGDSPSFIWTIQNGLNIPGRPEYGGWGGRYARVTEDSEINEYGTSADTLINNNGDSWRSQYATIWRWRDAYQDDFAARIQWTIVDKFEDGAHPPKISINGSTDSEPLRFDVSLNGTMILDASKTYNIDSDDTSGLTFEWYSYAECALPFLTSLNANFFKIEALSPPSGTNGTLTVNEAGFSNVTLGPVVRISTALGNWVQEQPSSVDKEWHIILQVTNNKGSYPIRRYKRVILQIPDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I1S4B5</accession>
    <accession>A0A098D221</accession>
    <name>I1S4B5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T00383</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF71991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315744.1">
        <property type="nucleotide sequence ID" value="XM_011317442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S4B5"/>
    <dbReference type="EnsemblFungi" id="CEF71991">
        <property type="protein sequence ID" value="CEF71991"/>
        <property type="gene ID" value="FGRRES_11682"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11682"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00383"/>
    <dbReference type="HOGENOM" id="CLU_2210294_0_0_1"/>
    <dbReference type="InParanoid" id="I1S4B5"/>
    <dbReference type="OrthoDB" id="10350923at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF71991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF71991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="107" mass="12284" checksum="96BAA93AD0DE0025" modified="2012-06-13" version="1">MVSVREIMHFRAEMLSIQGIVLPFRAVIVLIEDTFLPVRAAIDPFRVASVPREVGAEGFDSARAVDHGLGQEIWAWILRYKYRKTDGVKVLYWTLRLEFEALVDQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1S4T6</accession>
    <accession>A0A098D3A9</accession>
    <name>I1S4T6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG00888.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T02237</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316621.1">
        <property type="nucleotide sequence ID" value="XM_011318319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S4T6"/>
    <dbReference type="FunCoup" id="I1S4T6">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1S4T6"/>
    <dbReference type="EnsemblFungi" id="CEF72920">
        <property type="protein sequence ID" value="CEF72920"/>
        <property type="gene ID" value="FGRRES_11854"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11854"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02237"/>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049351_0_0_1"/>
    <dbReference type="InParanoid" id="I1S4T6"/>
    <dbReference type="OrthoDB" id="433955at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF156">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF72920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="355" mass="39423" checksum="8A9C35EC04B92764" modified="2012-06-13" version="1">MGIEALDFPQMWERPSYTQLADILKTLELSPPIWNHKRRRSDIIEEQESLAGQRKAEVTRYLSSIIKSPLSWIEDDDEKEILWTQASKRMSERCGRTAMGEVIRSWPFEDGADEFELIIREPALTGDSLGFKTWGSSYVLSQHLPRMAETSLFRLFDETLGQPRPDVLELGSGTGLLGLAAAAFWKVPVALSDLPNIVPNLRENVAKNADLIKSRGGSLTVGDLTWGGSEDEIDQTLFGQPNQFKIVLAADPMYDDDHPALLASAISDHLALGSDSRAVVMVPRRDATTERLLESFRQAMLDLDTPLFCEEEDELAGQDDWVEDDEAGNVRCWLGVFSRGGSPLSVVNDTASVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1S6B8</accession>
    <name>I1S6B8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T13591</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321951.1">
        <property type="nucleotide sequence ID" value="XM_011323649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S6B8"/>
    <dbReference type="EnsemblFungi" id="CEF78599">
        <property type="protein sequence ID" value="CEF78599"/>
        <property type="gene ID" value="FGRRES_12389"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12389"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13591"/>
    <dbReference type="eggNOG" id="ENOG502T1M9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037438_1_1_1"/>
    <dbReference type="InParanoid" id="I1S6B8"/>
    <dbReference type="OrthoDB" id="4358152at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF78599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="472" mass="53507" checksum="25013047499AD509" modified="2012-06-13" version="1">MDVFAKLPPELVAAILAELPDLQGLYNVVRASPGVSRFLNSPLGAGILDGLLDSWSSAIPQEFLTTDCGSHNRCIETGNLGVTPWVPYILRLIALFRHCNVKNQPADDLASFVIEFVMPSKNVEGVPELRPMPPHCVPNIRLQDVLGGTQAFSTRELLFLVRKLLVLAGECFDFFLERIKSTRPQHLAKKPSSLDQPLMWGHRPDGQPWGKAYEINTGHEASWYETQRLILGFCCLQLRYEISSAVFEGRLDWPADDVKRIRSMGQADSCVPIFAKSNIHMALEPMWAAAIYVASLKGASIDSSCVGDTNIESNRRSVFYDTGFRSLEEGHLRLPRPKHEDPSSEWPKTAVRHPDVFYHGESLYTDYSVVISGSKGSRWAADILCPLRGCQMTEGLLFRPLRRLGFGVWDDERMAQMEMIDDPNAEWHIPRRFSHWGKDQAFTWASLLSDEEKQELRVYQEVLRSKEEEKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1S6M5</accession>
    <accession>A0A098DHJ0</accession>
    <name>I1S6M5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T12243</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322585.1">
        <property type="nucleotide sequence ID" value="XM_011324283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S6M5"/>
    <dbReference type="STRING" id="229533.I1S6M5"/>
    <dbReference type="EnsemblFungi" id="CEF77925">
        <property type="protein sequence ID" value="CEF77925"/>
        <property type="gene ID" value="FGRRES_12497"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12497"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12243"/>
    <dbReference type="eggNOG" id="ENOG502RS7F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_7_4_1"/>
    <dbReference type="InParanoid" id="I1S6M5"/>
    <dbReference type="OrthoDB" id="3553147at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="46"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="624" mass="71051" checksum="1D365502D3FF0D8D" modified="2012-06-13" version="1">MSAYTYKPVSKSEIRLVSFKTSGSDGQQLEASIKNVELDPDHPITYTALSYCWGIAVERIEVPCDGEMLSITSSLHEALVEITKSRQNEALWIDQICINQEDMDEKSEQVSKMNMIYDILAWLGPAVYNTELAIDFVKKVGDVALPTATDMFRWDSYGEAHEETKLERTEELTNEQSGELGLPFDDDNSWTAFVDFFDRPWYQRMWTVQEIIQARKAIVQCGPHSLPWEHVSAAARWYIYKAGAIRQDYPREVDGARLVTQMTTIAWRTKMGSEYYRELFNQEARPSCRWGMRDLLENLRPRLATDPRDKVFALLGISDIDRELWDDRGMTVNYSKSVEDVFTQATDEIIKSDTSDLNVIWSARQRNDEAEWPSWVPDWRLETGTGCAWGIGAPLKTKGKPNGEHVYIPTTEPRSLAVKGKVIGRVTYKNEYRHFGELFRDSHLREVYNACMERLSVYPTGEDVKTAFGLTLIGGLPFPATLQKKETSVETYAAMYMQFYDNTQMPMGTAEEKAKRDEALAETYKVGLDMTWLQAVLAAYCERRFIVTDSGHMGLAHHQVLEGDVIAVVMGLEWPCVLRPKSNGEKHDQGYEFIGDAYCHGVMNGEAMEGIISGNDEGQVFTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1S7L0</accession>
    <accession>A0A098DZQ9</accession>
    <name>I1S7L0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T18983</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324484.1">
        <property type="nucleotide sequence ID" value="XM_011326182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S7L0"/>
    <dbReference type="EnsemblFungi" id="CEF86358">
        <property type="protein sequence ID" value="CEF86358"/>
        <property type="gene ID" value="FGRRES_12833"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12833"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18983"/>
    <dbReference type="eggNOG" id="ENOG502RKUP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_780849_0_0_1"/>
    <dbReference type="InParanoid" id="I1S7L0"/>
    <dbReference type="OrthoDB" id="5089449at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF86358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="313" mass="35794" checksum="8B247080010F4346" modified="2012-06-13" version="1">MQQDIGILHEKQREITSQNRHLWAYNSQLRRDVSDLRTQLSYTAQDLAARIQEQSNFDRLAGSYDKETRLQGRIDEQNEIIEKLLQDKIANANRIQTLERSQIKGTEPPPQIIADAEPKKTKSQKRRERRQAENEARCKEQSEKRERRRGRNNLKREKNKLNNLSTPASVPAPAHTPAQPVRVTRSNSIKAEEIADLELTNDNAAAEDIVSDLLLLDDNSHSKEAIEQLKRYIAKCTSRKNLHSFLQNGTKNRCFCFHEVAAKGSGATEQLFPSGKYCKVNGPYCNVLVQVVEMASGNRLRAFFPWGAYAPYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I1S7T7</accession>
    <accession>A0A098DYE6</accession>
    <name>I1S7T7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T20125</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325020.1">
        <property type="nucleotide sequence ID" value="XM_011326718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S7T7"/>
    <dbReference type="EnsemblFungi" id="CEF86384">
        <property type="protein sequence ID" value="CEF86384"/>
        <property type="gene ID" value="FGRRES_12912"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12912"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20125"/>
    <dbReference type="HOGENOM" id="CLU_1917248_0_0_1"/>
    <dbReference type="InParanoid" id="I1S7T7"/>
    <dbReference type="OrthoDB" id="10376030at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124840" evidence="1">
        <location>
            <begin position="24"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF86384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="132" mass="14220" checksum="BC2D53DD0C4082E8" modified="2012-06-13" version="1">MALPTSAGGKGPVLMLLLALAYCYDTYGYCRCCHEQGEGACSSKEEEKLESAEWVFPAKVGLASTKIAVGMERYCANKSGGRPCGVSPCYHHSFLVLLAPTTTLGWLPGCTGDRPYVDCVEVIMVHRDHNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I1S929</accession>
    <name>I1S929_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T10033</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320300.1">
        <property type="nucleotide sequence ID" value="XM_011321998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S929"/>
    <dbReference type="EnsemblFungi" id="CEF76819">
        <property type="protein sequence ID" value="CEF76819"/>
        <property type="gene ID" value="FGRRES_13359"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13359"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10033"/>
    <dbReference type="HOGENOM" id="CLU_2197209_0_0_1"/>
    <dbReference type="InParanoid" id="I1S929"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF76819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="108" mass="11922" checksum="1301D0475CCB9FAF" modified="2012-06-13" version="1">MSTIVSEPSRGFDVRTPKQIVVFAGMTFAQRMMSAYARAASGDNRNLIRKETAHLMLTDGGCRSMAYGCEYQGPQSACNLYSPKDFPTAMFHASERGIFERGQTDHGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1S951</accession>
    <accession>A0A098DCJ8</accession>
    <name>I1S951_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T09743</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320427.1">
        <property type="nucleotide sequence ID" value="XM_011322125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S951"/>
    <dbReference type="STRING" id="229533.I1S951"/>
    <dbReference type="EnsemblFungi" id="CEF76674">
        <property type="protein sequence ID" value="CEF76674"/>
        <property type="gene ID" value="FGRRES_13381"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13381"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09743"/>
    <dbReference type="eggNOG" id="ENOG502SJQV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021598_0_0_1"/>
    <dbReference type="InParanoid" id="I1S951"/>
    <dbReference type="OrthoDB" id="5422579at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="485" mass="55919" checksum="C4982F98BE25041D" modified="2012-06-13" version="1">MEGMPSPPAGLSSLPPELGDYIASFLTNRDIKSLRLTSSSVCRIVTLRLERVFIGANPRNIQVAYEVANHETFRKRVKEIIWDETYFNRESVAMRDYSKNDWYTHLCRDEIGRLAMSKGRPGDAARMCQLAAAMGSVESIEVYKELLRGQSSVLESGADVKAFEYALDRFTSLRRVTISTKTHGRLFMPIYQTPMIRSFPYGFVYPFPRPVIQGSYFFRNNETIERRGVYSTLRALAKHGKHNVSEFIIDDEMRYRLGRSDGTDDKTALADLRSLVQRPGFHRLHLHNKHPIQMYKVLEKAENLQSLCFQVEDYDPSHRWNPSAAQASDGVAAQMNISLNFLCHSPKACRTSQSKDRPLRPKVTILFSEMLRSPVQILKIDSQVNEFLYEDGENPFSPTEYCRDIMSHEMSYIIWMRSGKGFWIDELDPEYERPNYDENILERLHREQNFSIRELRRPNSWGDGPWGPQTCPTLEEQGIDPDCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I1S975</accession>
    <accession>A0A098DDP4</accession>
    <name>I1S975_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
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    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T09525</name>
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    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320528.1">
        <property type="nucleotide sequence ID" value="XM_011322226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S975"/>
    <dbReference type="EnsemblFungi" id="CEF76565">
        <property type="protein sequence ID" value="CEF76565"/>
        <property type="gene ID" value="FGRRES_13405"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13405"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09525"/>
    <dbReference type="HOGENOM" id="CLU_1343360_0_0_1"/>
    <dbReference type="InParanoid" id="I1S975"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF76565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="204" mass="22470" checksum="7DD696BACBACE967" modified="2012-06-13" version="1">MECLIWSVCPGVALHLVPRYYGIHPVSTPTHSDVLAQVITEARGYKSAGYNGTGIHKQSIDRLCRDPPTSRRAERIGRLGFLTLDFYTARLRLFPSWIGSVSERQYQASTIRDRKSRLDHSSFVPTCQTSSGTVMYSPVCPDSAIHAAYTYTSIARPCYANHAQVIADLYISTINAISQAGVSSLMTMDVPVVILILVTRANSS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q4HYZ2</accession>
    <accession>A0A0E0SEP1</accession>
    <accession>V6RPQ4</accession>
    <name>EXO84_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName>Exocyst complex component EXO84</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">EXO84</name>
        <name type="ORF">FGRRES_09816</name>
        <name type="ORF">FGSG_09816</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the exocyst complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
        <text evidence="1">Cell periphery. The polarization of EXO84 requires actin cables (By similarity).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EXO84 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS231668">
        <property type="protein sequence ID" value="ESU16446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327870.1">
        <property type="nucleotide sequence ID" value="XM_011329568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4HYZ2"/>
    <dbReference type="SMR" id="Q4HYZ2"/>
    <dbReference type="FunCoup" id="Q4HYZ2">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="STRING" id="229533.Q4HYZ2"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T26209">
        <property type="protein sequence ID" value="FGRAMPH1_01T26209-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G26209"/>
    </dbReference>
    <dbReference type="GeneID" id="23556748"/>
    <dbReference type="KEGG" id="fgr:FGSG_09816"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26209"/>
    <dbReference type="eggNOG" id="KOG2215">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012488_2_0_1"/>
    <dbReference type="InParanoid" id="Q4HYZ2"/>
    <dbReference type="OrthoDB" id="642193at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000264">
        <property type="entry name" value="Potential exocyst complex component Exo84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25345">
        <property type="entry name" value="PH_EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-0268">Exocytosis</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000118982" description="Exocyst complex component EXO84">
        <location>
            <begin position="1"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="142"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="679" mass="76462" checksum="DFDEFEE1AFE6CD77" modified="2005-08-16" version="1">MEDRNKISLRSGRRKKRPTISAPRQISGPIAQDDSNRPPLPGADPSQASAQPRPRPPPMAGGKTSDLVKRRYSTRFNQPSSISNGGAPPMPQMPSLANYEPRETVAAARKPPSRSGPGVAPVIDIKGLRDPKLKPDRYVQAALSDATEDQIREFEESLRQVKTRVGTDLQQSVMQNRTQFIKISKEAEKLKSEMRNLKNFMSELKVNTTAMRAAAAKSDEPMPSDLGVAPGISSRRDRRTSIADRSAMWNSQMQALYKGVEGSQKFLPNAVGRHVVQDAGPWIELDNATYKSRRAMQIFLLNDHLLIASRKKRKADAPGADARGPMMKLVADRCWPLLDVEVVDMSSTGESSNSGRNKLADAIMVRGVGQESFIYRTEKPQDPEKKQLLLNVRKAIEQLRKGLRSEMEANNKARETINYFASRDPGLLQKTELLATLSDIKDMLIEVDGKQQNLRWVESEMDDLDIDVAMQRFEDAVVRVEKLKAIARGLKNHAIAQDFINFKVNERCVRLANMIGRELEMTHDNNTKTRRNVSWLTRLGFEDSARESYLAARSGTIHKRTRQCIFQGDLHLYIWELSFVYFMVIHNTVQCFQSCFPPPMMSVCVKWAKEEVDAFNIILARQLSSTELRGQVWTQCMERAKEHSKLLSEVGLDFENLVGKNLMIYEPIDQGPSVGLGLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q4I283</accession>
    <accession>A0A098DDP9</accession>
    <accession>A0A0E0S0P8</accession>
    <accession>A0A1C3YM77</accession>
    <accession>A0A1I9F777</accession>
    <accession>I1RWK2</accession>
    <accession>V6RRR9</accession>
    <name>NACB_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName>Nascent polypeptide-associated complex subunit beta</fullName>
            <shortName>NAC-beta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Beta-NAC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">EGD1</name>
        <name type="ORF">FGRAMPH1_01T10541</name>
        <name type="ORF">FGRRES_16993_M</name>
        <name type="ORF">FGSG_08675</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the nascent polypeptide-associated complex (NAC), consisting of EGD2 and EGD1. NAC associates with ribosomes via EGD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <text evidence="1">Predominantly cytoplasmic, may also transiently localize to the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAC-beta family.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="ESU14640" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="SCB65642" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="DS231667">
        <property type="protein sequence ID" value="ESU14640.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65642.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320065.1">
        <property type="nucleotide sequence ID" value="XM_011321763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4I283"/>
    <dbReference type="SMR" id="Q4I283"/>
    <dbReference type="FunCoup" id="Q4I283">
        <property type="interactions" value="1258"/>
    </dbReference>
    <dbReference type="STRING" id="229533.Q4I283"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T10541">
        <property type="protein sequence ID" value="FGRAMPH1_01T10541-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G10541"/>
    </dbReference>
    <dbReference type="GeneID" id="23555667"/>
    <dbReference type="KEGG" id="fgr:FGSG_08675"/>
    <dbReference type="eggNOG" id="KOG2240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098726_2_1_1"/>
    <dbReference type="InParanoid" id="Q4I283"/>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000003">
        <property type="entry name" value="Nascent polypeptide-associated complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000273511" description="Nascent polypeptide-associated complex subunit beta">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="NAC-A/B" evidence="2">
        <location>
            <begin position="36"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="153" mass="16747" checksum="7590713728EA2BFB" modified="2016-09-07" version="3">MSDVQERLKKLGLGARTGTGKGTPRRKVKRAPARSGADDKKLQLALKKLNTQPIQAIEEVNMFKQDGNVIHFAAPKVHAAVPSNTFAIYGNGEDKELTELVPGILNQLGPDSLASLRKLAESYQNLQKEKGEDDDEIPDLVEGENFEGEPKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>V6R0U9</accession>
    <name>V6R0U9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG00348.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T00923</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316005.1">
        <property type="nucleotide sequence ID" value="XM_011317703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6R0U9"/>
    <dbReference type="SMR" id="V6R0U9"/>
    <dbReference type="STRING" id="229533.V6R0U9"/>
    <dbReference type="EnsemblFungi" id="CEF72264">
        <property type="protein sequence ID" value="CEF72264"/>
        <property type="gene ID" value="FGRRES_00348"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00348"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00923"/>
    <dbReference type="eggNOG" id="KOG1041">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004544_4_3_1"/>
    <dbReference type="InParanoid" id="V6R0U9"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="3">
        <location>
            <begin position="325"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="4">
        <location>
            <begin position="612"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="939"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF72264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="984" mass="109751" checksum="8AFCCFCBC432B6A2" modified="2014-02-19" version="1">MSDRGRSPSPGGPSGPGRRPSQSPARSATGSGSGPAGGYAKPLGYDPAKPPKQEDQGNTRMELPPDAYISETKKDMFTLRNNRFNTEGKPEHIEVNQYRMTKFDFNKKIYQYDVVLSPSPDKIGPVMKKIWAHPVTVKTMKPYKLEMWLFDGKKLAWSPALVDRGELRFSVDLDEGQRPPGAKPRDGGKFLVTIRKTTEIQVAALQGYLSHKMSFNNSVQEALNFIDHLVRQFPSRNLLAIKRNFYQTGRPGAPLQDGAIVEVHKGTYASIRMSDNLKQGGVGLGYNIDVANTCFWIGNQPLDRMACNFLATIDPSKFRGHTPATLNEILKPVRNRSGGWESSDGFKQLRKLRRLKFKIKHKGRPNEDKLYTIMDFAFDAKFGEAGHTSRTHTFEKDGKDISVYDYYKKMYNVTLRLSHLPLINAGKGGFIPMELAFVESMQRYPFKLNPDQTAAMIKIAVTRPAVRKADIQKGAAALQIGQDPYLREYGVNFEAQFAKTEARILPPPTVRFGQGTAEPKFAGRWDLRGKKFFKQNTAPLQNWGFVACEAPVPQAVLSAFATTFKTTFLGHGGKVTGDPMLLNAPSNLRFEPGKLVEWAHEEITRRKGYTQLLFIVVSKKNSGTYERLKKSADCRYGILSQVVLGSHVQKNNGQYHSNVCMKVNAKLGGATACTPPLWKTPTFFPDSRPTIIVGCDVSHAAPGGATASVASMTMSVDPNATRYAAVAQTNGYRVEMLTPSNIRLMFAELLPQWRHNHPGKIPAHLIYMRDGVSEGQFAHVLEQEVSEIKKFFGGSLPPDKIPKMTVIIATKRHHVRFFPQRGDKNGNPLPGTLVEKEVTHPFMFDFYLNSHVAIQGTARPVHYSVILDEMAMPVNDLQKMIYQQCYSYARSTTPVSLHPAVYYAHLASNRARAHENVATSDGFRTGAKGHEIIREKQAHGITSDAPNRTADAPPLIRLGGPCGQTPADGEKRQRDFFRSTMWYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>V6RGY3</accession>
    <accession>A0A098DNF7</accession>
    <name>V6RGY3_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Pumilio domain-containing protein NOP9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG07038.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T23799</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326729.1">
        <property type="nucleotide sequence ID" value="XM_011328427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6RGY3"/>
    <dbReference type="FunCoup" id="V6RGY3">
        <property type="interactions" value="919"/>
    </dbReference>
    <dbReference type="STRING" id="229533.V6RGY3"/>
    <dbReference type="EnsemblFungi" id="CEF83390">
        <property type="protein sequence ID" value="CEF83390"/>
        <property type="gene ID" value="FGRRES_07038"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07038"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23799"/>
    <dbReference type="eggNOG" id="KOG2188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008720_1_0_1"/>
    <dbReference type="InParanoid" id="V6RGY3"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="657"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="666"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="680"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="719"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF83390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="759" mass="85215" checksum="753B4E33715F7031" modified="2014-02-19" version="1">MPKPRTRRGVGREEKKRKRLEEAEQQQESYENDSKRQRTVEDENNNGYEYPDGQDAQQNGIGETEFFGMLAEEEQEYFRRADELLELNQFPSAEDRDIFLENVYKEAQGKELKLASSQSCSRLMERIIQLSNTAQKKHLFEAFGGHFLSLVQHRFASHCAEALFLRSAGVVSQELAGFVFDTKGTDTDMQKPETSMEDHFLATLDELEGALSYLVTDRFASHTLRVLLLVLAGRPLEDASVRSLVKSKKKEKISVAGSAATDEANQGLRAVPTSFALAAKKIIQDSTAGMDATALRVLARHPIGNPTLQLLLELDLTLNKGEQKAESEQPTLLFQLLPGAPKSLYDSSSEASEFVNGMIYDLIGSRLIETLITHSPGKIFKALNQNIFLPRIEGYVRNDISSYAAIRVLNRLSKDDLVQAVEKIAPSVPQLVVKSRLNVLKTLFERCNARGANDEIKKLNKGLKEGCGTTPADLVIFLSGLKDEEQKKKDVQQLSKNEYAIQSHGAQLLTTLLKIPGPTKGVQESLLALEPATIVRLATTSMPTVTVLTTALSISSANPAFHKSIASAILPHTHELAVSQFGHNLINAIVEVPSKGRERSIPFHMKEAFMARLGEHEAELRDSWMGRSVWRNWKGDMWKTRRGDWKIWMKEVDVDIPSTLPQRGPKTAEKEKPRSKPTEEIMEEPIVEEPVVEEPVAEDKMDVDEPVEQADNDDDAKKEKKKSKRDKKEKKEKKEKKDKKEKKKKSKSDDAKADDEMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>V6RHZ8</accession>
    <name>V6RHZ8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG05574.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T18239</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324126.1">
        <property type="nucleotide sequence ID" value="XM_011325824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6RHZ8"/>
    <dbReference type="STRING" id="229533.V6RHZ8"/>
    <dbReference type="EnsemblFungi" id="CEF87095">
        <property type="protein sequence ID" value="CEF87095"/>
        <property type="gene ID" value="FGRRES_05574"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05574"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18239"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_0_1"/>
    <dbReference type="InParanoid" id="V6RHZ8"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="42"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF87095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="537" mass="57919" checksum="1173A51499451532" modified="2014-02-19" version="1">MASTPPQADYGKEAVLDVSENQDVETGEVKNGGLQRDLKNRHMQMIAIGGAIGAGLFVGSGGALQKGGPAALLIGYLIIGIMLLCTCLALAEMAVLYPVNGAFFTYICRFVDPSWGFAMGWQYALAWLTVLPFELIAASITIKFWREDINMAVWVSVFLVTLIGIQFFGVRGYGEVEFVLSIIKICACVGFIILGIVINCGGVGDQGYIGVKYWQDPGAFTSFKGFCAVFVVAAFSFGGTEMVGLAAAESADPRRSIPMASKQVFWRIAIFYILNLFIVGLILPANDPRLMGASGANTKASPFVLAIQDAGIKVLPSIMNAVITVAVLSVANSCTFGSTRTIQAMAERNMAPGFFKYIDSKGRPLYCVLLQIAFGLLAYIGAAPQGMEIFGWLLALTGLGFLFVWGSICLAHIRMRAGMKAQGVNLGLIPYKTPFGVAGSYLGLGLNILALIASFYTALYPASGASPAAEAFFSSYLAFFSVTLLYVGYKVCTRKWQMYVRPSEMDLSTGAVFLEEEEPKEPFVWADAPKRVLRSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>V6RM66</accession>
    <name>V6RM66_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial intermediate peptidase</fullName>
            <ecNumber evidence="4">3.4.24.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Octapeptidyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">FG06865.1</name>
        <name evidence="17" type="ORF">FGRAMPH1_01T23365</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.</text>
            <dbReference type="EC" id="3.4.24.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.59" evidence="4"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326522.1">
        <property type="nucleotide sequence ID" value="XM_011328220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6RM66"/>
    <dbReference type="FunCoup" id="V6RM66">
        <property type="interactions" value="657"/>
    </dbReference>
    <dbReference type="STRING" id="229533.V6RM66"/>
    <dbReference type="EnsemblFungi" id="CEF84670">
        <property type="protein sequence ID" value="CEF84670"/>
        <property type="gene ID" value="FGRRES_06865"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06865"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23365"/>
    <dbReference type="eggNOG" id="KOG2090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001805_0_0_1"/>
    <dbReference type="InParanoid" id="V6RM66"/>
    <dbReference type="OrthoDB" id="17530at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000055">
        <property type="entry name" value="Related to mitochondrial intermediate peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="16">
        <location>
            <begin position="285"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CEF84670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="787" mass="88702" checksum="128BE9AE22CF0A4A" modified="2014-02-19" version="1">MLKSRGNRLWICNRCIQHTTKPPQRRWQSIASAVAQAVSPSNPVDHAASSSHDDAVLRNLFDAPAGRSFPKFSLKKSQGLFKNRYLTSPNGFHHFAQKNLERATKIVRKVLSASSIEEYQAVVRDLDRLSDLLCRVLDLSDFVRMTHPDARFQEAAADAWGMVYQYMNQLNTMTGLSDQLSQALSMPEVTKVWSEEERTVAEQLKLDFTKSAVNLPKASRDRFVDLSSRISEIGSAFAQGMQPAKKSLTLPAYKFYGLYPGIAATLKVRQNIVLPTLSSDAIGALQSVHDEDTRREIYLAQRTASKDTIMYLEAMLKLRGELAELAGFESYGHMALKDRMMAKTPSSVMEFLLALRDNNTPIIQAELQELIAKKRDRLNLPDVQLQAWDKDFYMEKTRVDLRSRQRREDQLNAFFSVGTVIQGLSRLFDRLYGIRLVLRETLSGETWHPEVKRLDVVTDKGELIAVLYCDLFHRPQKSGNPAHFTVRCSREILPDEVAEIAADQGNGPSFESPELAANDGMEVSTKDGVLKQLPTIALVCDFLPSENSKEPSLLSYQSVETLFHEMGHAIHSILARTSFQNVSGTRCATDFAELPSTLMEHFAADPTVLSLFARHWKTDRALPYELVAERIGLTKRFEGMETENQIILAMVDQAYHSSSIKNAGFDTTSIFHDIKARFAHGPRDPPSTCWQGFFGHLHSYGSTYYSYLFDRVLAERVWRVVFKAGENGGAINRENGERLKENLLKWGGGRDPWTCLSDTLQDERLAPGDEKSMALVGSWGIKDDHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>V6RQ48</accession>
    <name>V6RQ48_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG09735.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T26405</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327967.1">
        <property type="nucleotide sequence ID" value="XM_011329665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6RQ48"/>
    <dbReference type="FunCoup" id="V6RQ48">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="229533.V6RQ48"/>
    <dbReference type="EnsemblFungi" id="CEF85771">
        <property type="protein sequence ID" value="CEF85771"/>
        <property type="gene ID" value="FGRRES_09735"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09735"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26405"/>
    <dbReference type="eggNOG" id="KOG1061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006320_4_4_1"/>
    <dbReference type="InParanoid" id="V6RQ48"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="PHI-base" id="PHI:9142"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000044">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="29"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF85771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="713" mass="79201" checksum="F5AA66BEC781CA4D" modified="2014-02-19" version="1">MSSAAGGGDSKLFARGKVAELRLELNSGGKKDKNYAGKKIALKKIVANMTMSNNDMVALFPDIIGCMGIQSLEIKKMCFLFLVNYARMRPEIAVKAIPVLQHDMEDHNPLVRALALRTMSYIHVREFVEATVPIVKHMLKDGDPYVRKTAAFCVAKLYDHDRNMVESSDLIDRLNSLLRDDNPTVVASALAGLMDIWERSDAIKLTIDYSNASKMVAILPDCSEWGQTYILEALMSYVPQESGEAVLLAERISPRLSHSNSSVVLTCIRVILYLMNYIADQKQISALCRKLSPPLVTLLAKGPEVQYLALRNALLILQRRPEVLRNDIRVFFCKYNDPIYVKVTKLELIFMLATEDNIDEVLTELREYATEIDVHFVRKAVRAIGKLAIKIEPAARRCINLLLELVATKITYIVQEATVVIRNIFRKYPNQYESIISTLCEHLDSLDEPEAKAAMVWVIGQYADRIENSDALLEDFLYSFAEEPVEVQLALLTATVKLFIQRPTKGQELVPKVLKWATEETDNPDLRDRAYMYWRLLSTDMNAARQIVMGEKPAITAESERLDSATLEEMCLNVGTLATVYLKPVQTVFRSARPRKLQDSPALQKQNLLVAGDSQKSISMFGNAGAATDIDPRSRNPMSGDGQGNIAQAVSDADAYFSGIGTQQMTPMHGDQGDDVFGGGNGHSTGYVVSAHAPQAVLQPTQGAGSNGDLLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D1F0</accession>
    <accession>A0A0E0RNF4</accession>
    <name>A0A098D1F0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG00779.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T01957</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D1F0"/>
    <dbReference type="EnsemblFungi" id="CEF72779">
        <property type="protein sequence ID" value="CEF72779"/>
        <property type="gene ID" value="FGRRES_00779"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098D1F0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF72779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="142" mass="15869" checksum="B25684AAB4E48B40" modified="2015-01-07" version="1">MDALFENYCFTTPTNKDAKTDNISPEETTAQVAALEPRNNGITNEVSARLLRLARLTPELASHAIESPGTKQRLDYALFNLPVECRQLVLHRPRNLQLSADEARTHTMNKQVLIIRKSAARLSTSSNIMLDTEQVWHVSIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D862</accession>
    <accession>A0A0E0RTS0</accession>
    <name>A0A098D862_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FGRAMPH1_01T05681</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D862"/>
    <dbReference type="STRING" id="229533.A0A098D862"/>
    <dbReference type="EnsemblFungi" id="CEF74645">
        <property type="protein sequence ID" value="CEF74645"/>
        <property type="gene ID" value="FGRRES_02365_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05681"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098D862"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="8">
        <location>
            <begin position="91"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="9">
        <location>
            <begin position="389"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF74645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1245" mass="142928" checksum="15BA1908CDF3FCEE" modified="2015-01-07" version="1">MALTETSSWALEQQQDSQDEITCKEIKKDNVWVRIVIRLVFYPCSQAFQRLFIYFRPPSHNCSAAEEAKHGLGQKLHQLTNPDSSEHCVDIVAVHGLDGHWKRSWTATNNAFWLQDLLPVEIPCARIFSYSHDSRTRGSETPLDWDISDHATALLTTLSTERRLTQTERNPILFIGHSLGGIILKAALLKAELARVGHLEHFKAIKLSTYAVVFLGTPHQGGEGIPLVEVLCRISSIVSHTNTKILSKMERNSEWLQGLQSDYNAISQDIETIFFYETLKMDIGMKNLLIVPKHSAIISGARNSEEIPLIADHSSMAKFSTSKDDGFQTLVKKLRIFIDVAKLKVSENWKDWEWRNGPRVIQKQQPKVDQNGKEFALGIVSSITRNPYFTGRDEILRSLNQKLSLPLHSRGLSLVVLYGSGGMGKTQIATEYVHRHHADYTSVFWIDGSRNSTASADILDCIEALQQHYEVQGLRNRPWYSHIKETLAKRVKETHSASLSDVSDQSLRKMFLKWLSYDGNCGWLMVIDNVDDLDSFDFRDWLPPTLCGSIIMTSRRKDLALHWNSIEVDGMTIDESMELLNKSSRAVPVSHSAQDWNSSLELSFASKGIHYPWESTKDTAWTTWEISYEAVREANPLAARILSCCGFLNPTFITPLFFVLSNSTEYEVHQAFRVLVSYSFLKYRGVPNERIHYYSIHPLIHSWARHRMDIDKQKAFAQLTAAYLAIHSIDKIADSRRRNVIPDHLHVEHLLSIYEDLYPCTSHPSDIINIPARPQELAIGNTPPHYSIASFVEGCVLRLRGWMDEFYFFIKATYQPKQVHGHADYKILYSLHKKTRGLGADTMDWILCQALRSYPPKHPRMLEMIGHYFYSMSRNSGNSENSVIAGSWYQWLRLARFQVFGPRHPATTGKLDRVTVPKLYRKLPITDDVWHMRMSALGYDGITIRHELDELASSPYSLYYTKFLHQERLSAINKFVEKEGVENAKRLFGERTVLFYQMFAARDADVAPIQPTPPTWTLFLTMLEVFFDLFPFINKKTLVRWSRDVLDASYGLEKPPSSSHRERKAWLSAQPYLAGLHASLDMIPEFESSIYYPNPERIARMSNWLENDDWAPDAWDWRQLLPLARTAAKPSELSSDKSFLLSNEAEKDPSDQRPYFKWFHRVGPMLLEVRLSLVDGKANLYQCLYLNDSAAPQLQSFSFIFWKCTGQSYICEETFCHDWMAILLTLMGKLNIDGRSNLLDLRRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D8W6</accession>
    <accession>A0A0E0RUH5</accession>
    <name>A0A098D8W6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T06191</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D8W6"/>
    <dbReference type="EnsemblFungi" id="CEF74900">
        <property type="protein sequence ID" value="CEF74900"/>
        <property type="gene ID" value="FGRRES_15150"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06191"/>
    <dbReference type="InParanoid" id="A0A098D8W6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF74900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="74" mass="8403" checksum="266D746999911CE5" modified="2015-01-07" version="1">MYWLCFCASRVGSCWPSHTLSNESHDLGQYACKLEFYSYRIVRNVIASIRGPIVVNKNDSQLGSSDESSEYFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D991</accession>
    <accession>A0A0E0RUT2</accession>
    <name>A0A098D991_GIBZE</name>
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        <submittedName>
            <fullName evidence="11">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG02672.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T06405</name>
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    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D991"/>
    <dbReference type="SMR" id="A0A098D991"/>
    <dbReference type="STRING" id="229533.A0A098D991"/>
    <dbReference type="EnsemblFungi" id="CEF75007">
        <property type="protein sequence ID" value="CEF75007"/>
        <property type="gene ID" value="FGRRES_02672_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06405"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098D991"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF75007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="513" mass="58339" checksum="3CBAA4D25DDC7F86" modified="2015-01-07" version="1">MATDLDLVLGKSQYALFCGITLFSFFILKYSLLGNGGKQYPYINPKKPFELSNQRVVQDFIENARDILTKGRSLYKDTPYKAHTDLGDVLVIPPEFADALKSERQLDFTEVARDDTHGYIPGFEPIGSPFDLVPLVNKYLTRALAKLTKPLWAEASLGVNHVLGTSTEWHPINPGEDIMRIVSRMSSRIFMGEELCKDDDWLKVSIEYTVQLFQTADELRNYPRWTRPYIHWFLPSCQGVRRKLQEARDLLQPHIDRRNAVKKEAIAEGRPSPFDDSIEWFENEYEGKSDPATEQIKLSLVAIHTTTDLLSETMFNIALQPELLGPLREEIVTVLSTEGLKKTSFYNLKLMDSVIKESQRLRPVLLGAFRRMALADVTLPNGDVIKKGTKIICDTTHQWNPEYYPDASKFNAYRFLQMRQTPGQDKRAHLVSTSHDQMGFGHGLHACPGRFFAANEIKIALCHMLLKYDWKLPEGVVPKSKALGMSLLGDREAKLMVKRRAAEIDIDAIGSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DCA3</accession>
    <accession>A0A0E0RXV2</accession>
    <name>A0A098DCA3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FGRAMPH1_01T08549</name>
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    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF76077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DCA3"/>
    <dbReference type="STRING" id="229533.A0A098DCA3"/>
    <dbReference type="EnsemblFungi" id="CEF76077">
        <property type="protein sequence ID" value="CEF76077"/>
        <property type="gene ID" value="FGRRES_17403"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08549"/>
    <dbReference type="eggNOG" id="ENOG502QQVE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DCA3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43491">
        <property type="entry name" value="UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43491:SF2">
        <property type="entry name" value="UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase N-terminal" evidence="5">
        <location>
            <begin position="48"/>
            <end position="198"/>
        </location>
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    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase dimerisation" evidence="4">
        <location>
            <begin position="226"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF76077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="404" mass="44105" checksum="C8C65F01C8037A92" modified="2015-01-07" version="1">MLTPSDSPSESPFYPDTPPLSSSPSETDLSLNSAASASDITPETTPVVAVVGVGYVGTHLVSSFSSKYQVIGFDVSERRIKELDQEFQGNNRVRFSRTQSDLISATHFLISVPTLLRPNKSINSSYLRDALNMVSQVARRGSTIVIESSVAVGMTRELVGPMAKRLGLFAGMSPERVDPGRTFPPVKSIPKIISGLDDILPGSLDTIYRLYSTIFDNVVKVSKPEVAEMMKLYENCQRMVCIAYANEMADACIPHGIDPYEVCEAASTKPFGKFPLLEACSTAMNNRPSKLAQRLIDSLPSTGKRSRVLVVGLGFKAGQSQLDNSPGVDLVRSLAISGSDLDLTWADALVKQEAVPQVSRLADQDWNKSFLETFDVIVVAMKQHGMDFSLLEELEGVRVESWCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DCI9</accession>
    <accession>A0A0E0RY40</accession>
    <name>A0A098DCI9_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG10698.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T08725</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF76165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DCI9"/>
    <dbReference type="STRING" id="229533.A0A098DCI9"/>
    <dbReference type="EnsemblFungi" id="CEF76165">
        <property type="protein sequence ID" value="CEF76165"/>
        <property type="gene ID" value="FGRRES_10698_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08725"/>
    <dbReference type="InParanoid" id="A0A098DCI9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="118" mass="12862" checksum="9172558D078EC1A7" modified="2015-01-07" version="1">MHVSGANNVLCHILRGLLERLLQVEEACTRLVAHLSTENNALSNSSQGSLQGSYPQTPRQTPERRSVVSSAESQGFIDNDAEETEVSDLPSCPATSLNAEIIDKLLISKFPIVILIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DEB5</accession>
    <accession>A0A0E0S1B4</accession>
    <name>A0A098DEB5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG08843.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T10973</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DEB5"/>
    <dbReference type="STRING" id="229533.A0A098DEB5"/>
    <dbReference type="EnsemblFungi" id="CEF77289">
        <property type="protein sequence ID" value="CEF77289"/>
        <property type="gene ID" value="FGRRES_16957"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10973"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DEB5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="474"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF77289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="576" mass="63610" checksum="9EAF0666D12DF258" modified="2015-01-07" version="1">MVFYPPSSVKLPFDPPDSVTVPEFIFREDGVRKPHSRSRNPFTCGISGKTYTTAEVIERQKLLARALAKRLGYDIREGTEWDRVVALYSVNTIDYITMTHAVHRLNGIVTPASAAYSAPELEHQLRSSGANALFTCVPLLEVALQAAKGVGIPEDRIFLLPVPGAESKQPFKTINDLVAEGKDAPELKPLDWIKGQGERQVAYLCYSSGTSGLPKAVQITHRNVIANVIQATIQNEEGRKSAGVDAQIQLGLLPLSHIYGLVPVAHYGIYNGDETIILPKFDLKLLLSAIQRFKIQQMALVPPIFIQMMSNYAECQKFDLSSVRFIFSGAAPLGKETTIDLNKHWPSWKICQGYGLTETSPVVTSTSELDIDPGSSGTLLPGLKAKVIDAEGKEVTEYNKPGELYVQGPTIVLGYLNNAKATAETFVHHDDGRWMRTGDEVIVRKSPKGTEHFVIVDRIKELIKVKGHQVAPAELEAHLLTHPLVDDCAVIQVPDLRAGEVPKAFVVKAPQAKGKSDDEITQSINKHVEEHKARHKWLKGGIEFIDVIPKSPSGKILRRLLRDRERQARKETGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2024-05-29" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DES8</accession>
    <accession>A0A0E0RYW6</accession>
    <name>A0A098DES8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 2, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="8" type="primary">FG08170.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T09277</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DES8"/>
    <dbReference type="STRING" id="229533.A0A098DES8"/>
    <dbReference type="EnsemblFungi" id="CEF76441">
        <property type="protein sequence ID" value="CEF76441"/>
        <property type="gene ID" value="FGRRES_17089"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09277"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A098DES8"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:D-amino-acid oxidase activity"/>
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        <property type="term" value="P:D-amino acid catabolic process"/>
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        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
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        <property type="entry name" value="DAO"/>
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    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
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    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR11530:SF26">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G13940)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DAO"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="14"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF76441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="378" mass="40816" checksum="A80B1E5B92235140" modified="2015-01-07" version="1">MSSLSSSETTESTIVVIGAGIIGLTSALEIQQLIAESPSAASTSVLLVAKEWPTSIPGAPIAHSADYASMWAGAHVRPIPASTPQLRREAKWVKTTVAELEKHLQSEPGVGIRRLPGIEYLEDPPAEYVKQDATSFTAETGLPGYRKFEIHELPEGVKLGFEYETYCINAPFYSANLLRKFIVQGGKTVQRDLKSEWEAFILAPDVKLVVNASGMGFGDAKCFPIRGQTVLTNLTAADKTITAQKKDGTWSFVIPRSFNGGTVIGGTKEMGNWDLEPSQETRNKLLKAAESIIPQACSQEQDVGSLKVIKDVVGRRPAREGGMRVETESKDTTWGVKHVVHAYGAGGRGYELSWGVASEVAELAKEVLGSQSEVKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DES9</accession>
    <accession>A0A0E0S1U9</accession>
    <name>A0A098DES9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG02800.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T11343</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DES9"/>
    <dbReference type="EnsemblFungi" id="CEF77474">
        <property type="protein sequence ID" value="CEF77474"/>
        <property type="gene ID" value="FGRRES_16398"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11343"/>
    <dbReference type="eggNOG" id="KOG1807">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DES9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZNFX1" evidence="5">
        <location>
            <begin position="100"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="272"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="588"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="4">
        <location>
            <begin position="669"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="980"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1117"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1217"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="990"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1016"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1042"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1122"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1217"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1228"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1238"/>
            <end position="1251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF77474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1267" mass="142871" checksum="4FD1C7659E1ECC7B" modified="2015-01-07" version="1">MDREYEASRDHHPMEIITQHVMHRHGTDTQSRHWLTSPEFPQPEELMAEYPAELPAGPSDENPFDKNAYLEFQYAMNRFEGTELLRQAIKDFREKPLKSDRDKFYVYTQVRIHGYLLAKTGPACRISFSTECSETKVVWHQSTRLTPGTLVALSPRSDNFNAQCFVAVVAARYLLGGLEPNFDDGEDNSTPPRIEIFWSNVETAMFDPSVELVMIEAKGGYFETVRHAMVGLQHAAKFESKFDKYIINGSNREYTATYLSEEGALIPGKAKQFDSSQQEAFRRMTSRELAVVQGPPGTGKTFTSVVALESHILTLKAVQGGKAIPPVIVAAQTNHALDQLLDRCLSFDTVIARLGGRTENEDIESRTLFNIRKDSKIARGPTRGEALRKKVQSEIEDLLKGCFPAELIAAEEFLREELITQKQYESLKDEEYETIPIPGGNGQADDEAVDSIKSWLGGCVEYDQTYIYRPPEGQKESPETQDDVIDESKQENDRERLHGDFFPTKFYMTGSVPSRYGDGDAVSSQASRLLLKHHDLYEINLSLRGIVYRLLRKRLINARVKRFPKLLKAYQAACDDIKIARCERDVKILTNEKVEILGCTTTGLTKYRGLISALKPRILMIEEAAETREANITSALYPSLDQIILVGDHQQLVPHVDVHELGCEPYNMHVSLFERLVNLRLPYSMLQVQRRMVPAIRQVVNTFYHRLTDHSSVNDPRNRAPVLGMGNKSLWWFHHDWEESRNTDDFSYSNFNEASMIVCFVRYLIQNGVPPHRITILSFYKGQVTLLLEILRRDPTLSAKNPTKAWSVKTVDGFQGEENDIVILSVVRSAHPGFVQNKNRAVVALSRAKCGLYVFGNALNLVQKWEESFSTWIGVYEVFEEQGCLEGFILVTCKNHGRETKISSIEDWETIAAAGCGEPCTETCSEGHPCTKTCHPFKQSELRCEENCQRVLSCGHKCSSLCGDPCRCVQQCSEASAQLASSRTSRALEPRTLIPPLRLTRPPQTHVAKGFPATRGGRGGRPMTGQRGGQGGTVRRGTPRTDSSTSMRSSLESNRSASKNRTNSDNTGILLEQFNAADRDSSIQEPTSEQLMETGYYSKGGPSRWHEKITVQVKGNLELAPTPSSKTSLSDRWSPEKISQKDRVLGEEAKRASRQRSPYATVIRTTYRPTTMDPDGSRRYGLQTHSSHTVLKYSLTRKEMLLDVAAGQSIIDQHENHENHENHEKHEKHVKNKRHEIHVKNEKQGVGEERVVTAGEGSSVEDLISFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DFG2</accession>
    <accession>A0A0E0S2D3</accession>
    <name>A0A098DFG2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG02958.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T11709</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DFG2"/>
    <dbReference type="EnsemblFungi" id="CEF77658">
        <property type="protein sequence ID" value="CEF77658"/>
        <property type="gene ID" value="FGRRES_02958_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11709"/>
    <dbReference type="eggNOG" id="ENOG502RS04">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DFG2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010018668" evidence="2">
        <location>
            <begin position="20"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF77658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="224" mass="25285" checksum="2E9FF70060764426" modified="2015-01-07" version="1">MLTTTVFVVSTILVLTVLAYHRPSDFRTIIPVTIQDDVEEPTERFIIAFGDSYSRAGFKMNTSYIRTGPRMHDMKKTQRSEKKLVGSPRAENPIGNPELPGVTSSGGKNWAMYMATEFNTTLTLAYVFARSASVVDAEVIPPRRLMTFTFAHQIAHFNDTIGHRPDHAAWTGENAVVTIWFGINDLSIALGKQGQDEKPRASIRRIFELTEILYEIGHSKFYFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DKU1</accession>
    <accession>A0A0E0S4X6</accession>
    <name>A0A098DKU1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T13495</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DKU1"/>
    <dbReference type="EnsemblFungi" id="CEF78551">
        <property type="protein sequence ID" value="CEF78551"/>
        <property type="gene ID" value="FGRRES_15199"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13495"/>
    <dbReference type="InParanoid" id="A0A098DKU1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF78551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="71" mass="7836" checksum="C4987A3B864AAF06" modified="2015-01-07" version="1">MCHTDYRDVMCPACGDEKGLPVVVSKLDCTVKDTDDCVQTKSTEFDLITCADCVQAQAEEEEQGYMYSSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2024-07-24" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DN40</accession>
    <accession>A0A0E0S796</accession>
    <name>A0A098DN40_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG04377.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T15141</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DN40"/>
    <dbReference type="EnsemblFungi" id="CEF79371">
        <property type="protein sequence ID" value="CEF79371"/>
        <property type="gene ID" value="FGRRES_04377_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15141"/>
    <dbReference type="InParanoid" id="A0A098DN40"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="12"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF79371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="148" mass="16615" checksum="6BF4263841B50CA3" modified="2015-01-07" version="1">MSTEDSKPEGTYEAGCHCGHISLSVTLSPPLPEHEVTNCNCSICRRGGYLLVYPTHEKVTWHNGSDKRVARYMFNTKTRDHMFCPKCGASIGIDFEKKRPEKPLYGISVRQFNNIDLDTLRYKKFDGMHKMEPAVDLSGKEASASASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DNM6</accession>
    <accession>A0A0E0S936</accession>
    <name>A0A098DNM6_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">FG06450.1</name>
        <name evidence="16" type="ORF">FGRAMPH1_01T22307</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF82949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DNM6"/>
    <dbReference type="STRING" id="229533.A0A098DNM6"/>
    <dbReference type="EnsemblFungi" id="CEF82949">
        <property type="protein sequence ID" value="CEF82949"/>
        <property type="gene ID" value="FGRRES_06450_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22307"/>
    <dbReference type="eggNOG" id="KOG1417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DNM6"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="Jelly Rolls"/>
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    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
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    <feature type="chain" id="PRO_5010018712" description="homogentisate 1,2-dioxygenase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="460"/>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="361"/>
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        <ligand>
            <name>Fe cation</name>
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        <location>
            <position position="370"/>
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        <ligand>
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        <location>
            <position position="392"/>
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        <ligand>
            <name>Fe cation</name>
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        </ligand>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="392"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:16169"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
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            <dbReference type="ARBA" id="ARBA00023232"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF82949.1"/>
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    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF82949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="460" mass="51606" checksum="F523EE317287BC55" modified="2015-01-07" version="1">MNWILFMLIAIATQLVTMPVTNFSTSEKYSYLNGFDSFHESEAIKGALPIGANSPQKPPYGLYAEKLSGTAFTAPRHENRQTWLYRVLPSASHSTYQRFSNASEPILKAKLNYVPQQLRWDPFDIDEQVDWVTGIKLVSGAGDPTMKTGIGIYVFAAGKDMDEKTAMYSSDGEMLVVAQHGVLDIQTELGRLLVRPNEIAVLPRGIRYRVTLPEGPIRGYILELYQGHFQLPELGPIGSNCLANPRDFQIPVADFQEDTTSTWIILNKFNNELFVAQQGHTPFDVVSWHGKFYPYKYDLGRFSVIGSISFDHPDPSIYTVLTGPSDRPGTAIADFVIFPPRWLVQEDTFRPPWYHRNTMSEFMGLICGQYDAKTGGGFQPAGASLHNVMTAHGPDADSFEKASNSELKPMKVGEGSMAFMFESSLMLGITDWGLETCKKVQADYNKHSWEELKVHFKMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DQW5</accession>
    <accession>A0A0E0SCT2</accession>
    <name>A0A098DQW5_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T27145</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DQW5"/>
    <dbReference type="EnsemblFungi" id="CEF84245">
        <property type="protein sequence ID" value="CEF84245"/>
        <property type="gene ID" value="FGRRES_15549"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27145"/>
    <dbReference type="InParanoid" id="A0A098DQW5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF84245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="59" mass="6792" checksum="9575D6C005F64E1B" modified="2015-01-07" version="1">MNENARDWCDKSRDNGAGDDRMRCKGVGNWNATFTVRSQLISGRKRARYSAVLEKENKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DTH7</accession>
    <accession>A0A0E0SDZ4</accession>
    <name>A0A098DTH7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG06966.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T23627</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DTH7"/>
    <dbReference type="STRING" id="229533.A0A098DTH7"/>
    <dbReference type="EnsemblFungi" id="CEF84657">
        <property type="protein sequence ID" value="CEF84657"/>
        <property type="gene ID" value="FGRRES_16753"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23627"/>
    <dbReference type="eggNOG" id="ENOG502RJQJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DTH7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF84657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="341" mass="39251" checksum="7C2D0E93331C339C" modified="2015-01-07" version="1">MEGTTHRPSGNSPNPTHTYYRATQAQTPPGSTSGSPKVKIEEFASLPGLRNVVPTEVSSPVKLPSLGEFDQGVENLIRAHGPVKTEAVLSPLYGLTRNPTVLEPLTTITQPQPYWSIRNPSTENLVREQPNSRRGTTLRPSQYPFAADYSRQSMSSFSNPDSYYGYGSSPPLQGLPGMDCYPSPPPEGGESRHINQKYTTEEGDYIIYAWHDKKMKWQQIKQEFATRFGNTPERTVQGLQAWYYRMNQRIPIWDQEGWLCFDNEDDLEPQHISIKCRERDSQDKPSEPLGLAQRYPERAIHYSWVDPEIKFKSSDWAAKRALQYRDRRERRRRKEQCRLKL</sequence>
</entry>
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    <accession>A0A098DXU9</accession>
    <accession>A0A0E0SI94</accession>
    <name>A0A098DXU9_GIBZE</name>
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        <submittedName>
            <fullName evidence="6">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG04991.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T16823</name>
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    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DXU9"/>
    <dbReference type="STRING" id="229533.A0A098DXU9"/>
    <dbReference type="EnsemblFungi" id="CEF86157">
        <property type="protein sequence ID" value="CEF86157"/>
        <property type="gene ID" value="FGRRES_17634"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16823"/>
    <dbReference type="eggNOG" id="ENOG502RS7J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DXU9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
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    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF2">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
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    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="349"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="417"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="455"/>
            <end position="489"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="609"/>
            <end position="632"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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            <begin position="27"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="460"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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            <begin position="612"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="656" mass="72931" checksum="52A5CB04CBFD15D2" modified="2015-01-07" version="1">MPTINAHRTFEPPSMPSPPDFERRRSTASSLSHNTDSLGGLQSPPLRSRSSRPKSAKFSSYRLRSNSGLSLHTNEDILRQYTDYHPDGTPRAGLYSNGGGQWSAERLRSIDSVASSARSQRSSIAYTESDSSGELPIPDLVGREMFDMVMADHAASGQLWKFAADRGVGQNVDYLMKIRDYIQSLEQVVIQLSTISTSYTSITATSPLGLPPPMSKALNTNIKHLTTSLIPSLENMFLESKAFIEQRIVREIFPDFVKQQLSQCTSLALSLDAEGDSPLNPYPGLKGSFCLSDPSRSGNPIMLASDEFEELTGYSRTEVLAHNCRFLQGPQTDRDRIANMRSAIWRNDECTELLLNFRKDGTPFWNLLFLCPLLDKTGKTKFFMGAQIDVSSSIHDTDDVLKVLSYGAMEEERATERCSSRWASEASHDEPEHDEAFGIKNNTLKSKKATSFFKSFKKANPPPPSPPLSPRRSSDRPRSSGPTMDKTYSTRSVIRRFSSQPEMLMSTYARYMILEHVPSYPKSLGAMPLDQEGKYPPKLCVSFYSKEMSEALDLGPATEAVIGKDIFDIMTEQATLPSVTKAFKLTVRDLVVRDGKSVSLDLALANHIPRRANTSRSPTSDSDGPHKKPAKLMSHWTPLKDSEGHVKYVVMIVSPI</sequence>
</entry>
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    <accession>A0A098E2M9</accession>
    <accession>A0A0E0SLN5</accession>
    <name>A0A098E2M9_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG11096.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T21213</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098E2M9"/>
    <dbReference type="STRING" id="229533.A0A098E2M9"/>
    <dbReference type="EnsemblFungi" id="CEF87348">
        <property type="protein sequence ID" value="CEF87348"/>
        <property type="gene ID" value="FGRRES_17479"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21213"/>
    <dbReference type="eggNOG" id="ENOG502SYPD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098E2M9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38886:SF1">
        <property type="entry name" value="NACHT-NTPASE AND P-LOOP NTPASES N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38886">
        <property type="entry name" value="SESA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="282"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF87348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="596" mass="66708" checksum="2A28FEF17DE82A03" modified="2015-01-07" version="1">MNCLLKLPSLTVSENLNNNSSNFLLHKLTMEFALSAGAVGDFISIAALIKDIVVALDDSRGSAKQYRELVQQLNTLDQTLDTVQQTLKDPRMTHSLELISAIVLDTVTKTKKCLVDFLDQISKYEPALSTTAFVKKASLNGASKKVRWKATSNCRKVQWKLNEKDIDRFRAEVVGYTIALEMVLGVITIRLLQRNYDSLVREQQNAEKRTTDLIHRSKTSLGTSLDSIGRNIVSKLEIIHSLVAQLKTTTGHIVSLIQSVAGDISSIKAIVMHLDRGPGDEHFILENITGRRFPIHLKTITSWAVLEFILNERFKGKKGARRVQHKRYTLVEDKTHREVDQSIPWDGAFLPYQKINMSLICNEVEGNDTNGKGASSCPFCKMLSGSLASTGVELKWKVYALFPLESCGRFFTRVVEVNHGELNQVPGLAESSCSENVSDEDAYTRFHESKSISPQTRPGMGSLPSISGYDSDDEDVRATERLAVEDASNHIINHESDLTAPVLHPHSTPELDSTTSFGISSPQGQEEQRKGFKQKQRISNPNPPAVFLNMPPLSRVYTPDDIPKHRDDKRVCMDRSYRIMVEKPNSRATYSSRFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0S3U6</accession>
    <name>A0A0E0S3U6_GIBZE</name>
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        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="5" type="primary">FG03378.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T12737</name>
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    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A0E0S3U6"/>
    <dbReference type="EnsemblFungi" id="CEF78171">
        <property type="protein sequence ID" value="CEF78171"/>
        <property type="gene ID" value="FGRRES_16281"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12737"/>
    <dbReference type="eggNOG" id="ENOG502RV0S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0S3U6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010027130" evidence="3">
        <location>
            <begin position="21"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1268"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="945"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF78171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1292" mass="120044" checksum="B5AE5081755F09C2" modified="2016-04-13" version="1">MRFTTGILPTLGAIASLGEATPTFFTGGGGASGGVGGHLGAGAGVDAGAGAGAGLGAGAGVGGSAGGHLGAGAGVDAGAGVGGGAGGKIGAGAGVGGGAEGHLGAGAGVDAGAGVGGGAGGKIGAGAGVGAGVGGKIGAGAGVDAGAGAGVGGGAGGKIGAGAGVDAGAGVGGGAGGKIGAGAGVDAGAGVGGGAGGKIGAGAGVGAGVGGKIGAGAGVDAGAGVGGGAGGKIGAGAGVGAGVGGKIGAGAGVDAGAGVDVGGGAKGGLKGGAGGHLGAGVGLGGKIGAGVGAGAGLGGHLEGDVKGGAGGKIGAGAGLGGHLGGGLGVGAGIGAGLGAGVGAGIGLGLGGLGGLKGLLGGGIEWSAGGGADWHTGTSCSIGNTWKDHVLFQGVCSPETETTPAVNLGLNLPSCQITGDIGFACGADFLKTPNVRVGLGGISAYIEIDLSASAAVHQSVELFAAPKLGVAIPGLEASADLKAAIEAAIALDLIVGCGKAIDLSAGVYVKFPADAYVDIDLLTKKVINASLEGLVTKALPVGVGADVELGAGIDLQIGLRLRSELAIPGGLEIPVLGLSGKAGADVGFGAGVWFSLLDYSAKIGGGAGVSAGIDITGSFDCNLGLSVDKKWDFSGGFFNLIPNLSVGLAKGIKSTFSQKTRGTCGSFIGHFKKGGFIGGPTIPASGLITATTAGSDASVTIPAGVTQSVEFSGTVVVPDASVSVEIPDSTDSASPEGPSDVTGSGSLPVATSAAEIPDTTDSATQGGPPVDATESGSSPVTTSAGEVPVGPGGEVPNQTITKGGDVTAIFGPGETITVSGSEGFTTILSGSEGFTSVITGSEGFTTVISDSEGSFTSFFSGSEGFTTVISGSEGVTKVVPGTPGFTTVVSGSETFTQVVPGAGFTTVVSGSETMTKVVPGAAFTTIVSGSETFTQVVPGGGFTSVQSGSSPVSTGGNNYELPSAPGADATASGDVPAETGSGSLPAATTAPNGDNGTPGDATTGSGSDAEVTSAPAAGVTEAPDASGMITSTIRETHVYTITSCAASVINCPASYTQKIVTQTVIERTTVCPATATAVPNTPTEGSDESGKTPDSPDSPDTPKEGGNASHQGPGGDKGAEYPTPGDKTPVEGGNGSGSHGDAPAPTAPPAAAQTTIDLVTITQDVTTIVPCTKFVTSTFVAPTTVHPPAVPVVTIIDNHTGQAPQNTATEQPGAFTTLTRVMASATDSGDYPAATDSGSDAAAPGYEAPGAVPTYKVPNNGTVPSQVPVIAGASLVSVGSMLLALPMALAFIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0S8J5</accession>
    <name>A0A0E0S8J5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG11520.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T16041</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0S8J5"/>
    <dbReference type="EnsemblFungi" id="CEF79820">
        <property type="protein sequence ID" value="CEF79820"/>
        <property type="gene ID" value="FGRRES_16048"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16041"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0S8J5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF31">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR_REPRESSOR MOT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="71"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF79820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="695" mass="77284" checksum="288E0574357A6822" modified="2016-04-13" version="1">MASTNALPIVFSPLSQPGPSSQPFRCQVCSSRFTRHENLKRHTALHSRSSGNASIPCHLCPATFSRSDLRHRHMKRKHLDQMEKASRHKQQRDLQALTPPSQANEGVVAHQPRQGQASTDDDGSNLPSTGWPGSRDIRTDTANLCSSLPSDSGNNHHPQKVANSSQSQFIPDGSVNIEPTILSTIDSQLLNFDFLEPSSNHQSSHMSTSPFGTSLLSFNLDQGSPERLLYGSIDLTQSQIDWHPSNMQIKTGCELYFKHVSHFLPFLHRPTFNSTDITSHLLLGMLCIGYQYDEDPDCNNQQGSGVELSERCFHRARALVSGEKYMTDGSTHNLSIVQSYLLLEIYAMMYLCGNHSAYGLKTHSKMISLARSSGLSLPIPSEPTATSDLDSLWHTFIASESQKRTLFAAHQIDTLWYQFLSIPRQFSHLEIKHELPCPEDQWMASSAAEWAHKKLVTSMSGSAVQYPDAIRRFLSSPSDLSSLPAFDPYGAINITHFLISSVQEVSGWCTMTGMISMERLEPLRTSLQALGAFIHSDLEHGNLSRGALCKASWESAMIEVRVWSPSHTSGIVGGTMDAFLQHSTYLPPSCEFLCESNTAKAIKPHIDWFLAYLDAPIVPDSEAPWIMLYAFKAFIIAWQLVQGSTLGSMEVVGVQDGDDDGALEWAKRVFGRRRRWQLGKIIMTCLDTLKTSVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0S8W1</accession>
    <name>A0A0E0S8W1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG06621.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T22751</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF82874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0S8W1"/>
    <dbReference type="EnsemblFungi" id="CEF82874">
        <property type="protein sequence ID" value="CEF82874"/>
        <property type="gene ID" value="FGRRES_16687"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22751"/>
    <dbReference type="InParanoid" id="A0A0E0S8W1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF82874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF82874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="528" mass="60143" checksum="5E15A03476F560CE" modified="2016-04-13" version="1">MSSRPERPLSTGSNPTSKRQQARQIAATHDEVALKIAKELLQARPPPEQIDLDIMPGLGISHELSQDNEAEAMQLFVESAEWESIDAFDEFAAASQDFKILWKTSVRVLHMPPNCMLAPQNLLQYGTSTSISDKVVFGSDFSKLLTSLIIHPVWGHKFGMFRLALQFAVKCRIGHRGVWPEKEHHARGYQAIETLRHMLYQSRDGPETISDMLAKAIGETEIAQDFPVFLLTIADYVKKEDGHDLESYTQCHGLFAFPVLIEDLRAIERALNNYPWVEKSWMTTTARIWAAFKSELGNDKVEFPEPGQLKEYLSRNVEYVFRVMFSRKKQKKDQGGPDARLSQSLPGEQERNAMDDRISRLERGHAELASRFDQERLRNAELLKRVEALESESLSTTRSSNNSQLRTENELLNGQLERVREERDTAKDQLREEARIRLENLTQARDQLSKAHDEIDSLESAKGNSQVELESLRNTNVELTKELSDVKQGCNNAQKNLIEATQGWSETLKDLSEARQKIASLERGQSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SC40</accession>
    <name>A0A0E0SC40_GIBZE</name>
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        <recommendedName>
            <fullName evidence="17">Endonuclease</fullName>
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        <name evidence="21" type="primary">FG06686.1</name>
        <name evidence="20" type="ORF">FGRAMPH1_01T22919</name>
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    <organism evidence="21">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="21">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="22">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="21">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="20 22" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="20">PH-1</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="FGRRES_16702"/>
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    <dbReference type="eggNOG" id="KOG3721">
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        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Nuclease 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
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    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
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    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
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    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="19">
        <location>
            <begin position="105"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="18">
        <location>
            <begin position="106"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CEF84003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="346" mass="37754" checksum="F20D18CB9E2FB387" modified="2016-04-13" version="1">MSKTTLATMACLGAGGGAAITAAVYSIRGGKRVEETNTLATPPPTTNSFAALPAPTASPSIPPTQVFGPPAGAPPSSTPVDINAIVNPAGLFEYGFPGPVADVANRSGLVSSYDRRLRNPHWVVEHITPQSLAIREGDRKHSNFVEDESVPQKFRAGLKDYYRSGFDRGHQVPAADCKWSQKAMDDTFYLSNMCPQVGEGFNRDYWAHFEDFCRRLTVKYPSVRIVTGPLYLPKKEADGKWYVKYEMIGSPPSVAVPTHFYKVIFAEDGRAGGNVALGAFVLPNAPIPNSKPIGDFEVPLEAVERASGLEFATKLPPQRRRRLCADHTCALVIKEYAERQKAFPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SCC3</accession>
    <name>A0A0E0SCC3_GIBZE</name>
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        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T25043</name>
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    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SCC3"/>
    <dbReference type="EnsemblFungi" id="CEF84086">
        <property type="protein sequence ID" value="CEF84086"/>
        <property type="gene ID" value="FGRRES_15434"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25043"/>
    <dbReference type="InParanoid" id="A0A0E0SCC3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF84086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="66" mass="7076" checksum="AEA538A252416888" modified="2016-04-13" version="1">MASSRSAHLTSPTSEPYKSVRVIAQELRQEPVDGSIGATDGTMRQKQPIVACLQHAILSLAPLGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SGH7</accession>
    <name>A0A0E0SGH7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG07263.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T24373</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CEF85540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="229533.A0A0E0SGH7"/>
    <dbReference type="EnsemblFungi" id="CEF85540">
        <property type="protein sequence ID" value="CEF85540"/>
        <property type="gene ID" value="FGRRES_16798"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24373"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A0E0SGH7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:NADH dehydrogenase activity"/>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
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        <property type="entry name" value="FAD/NAD-binding_dom"/>
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        <property type="entry name" value="NDH-2"/>
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    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
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    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF17">
        <property type="entry name" value="NADH DEHYDROGENASE (EUROFUNG)"/>
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    </dbReference>
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        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Pyr_redox_2"/>
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        <property type="entry name" value="FADPNR"/>
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    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
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        <location>
            <begin position="10"/>
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            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF85540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="455" mass="50353" checksum="0DBAE017827B148D" modified="2016-04-13" version="1">MSFFSAHKERIVVLGSGWAGYALAKKISPSAASCVLISPRSHFVFTPLIASTAVGTLEFRAAVEPCRKLTHTEFHQAWASDIDFANKSITVEANHRDGVTARSGKDLKGPEFQIPYDKLVVAVGCYSQTFGVEGVKEHACFLRDATDARTVRLRVLQKFEQAALPSTNTAERKRLLHFAVVGGGPTGIEFAAELHDLIHEDLSKLYPDLMPHVAITIYDIAPKVLPMFDQNLAAYATNIFKREGIRIKTEHHLQGIRRQGDVLLMRIKEEPEEVAAGVVVWSTGLMQNPLVGKTVGREVEGLGKIAKNDKTGGFAVDSHLRVQVESRDLNGKEITKSLPDVYAIGDCANIEGQALPATAQVASQQATYLGKRFNSGISSQGPPTAPFHFRNWGTMAYLGGWRAIHQNGADELKGRAAWILWRTAYLTKSMSFKNKLMIPYYWLITWIFGRDISRF</sequence>
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    <accession>A0A0E0SN93</accession>
    <name>A0A0E0SN93_GIBZE</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SN93"/>
    <dbReference type="EnsemblFungi" id="CEF87906">
        <property type="protein sequence ID" value="CEF87906"/>
        <property type="gene ID" value="FGRRES_20248"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17141"/>
    <dbReference type="InParanoid" id="A0A0E0SN93"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF87906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="33" mass="3613" checksum="65E2055FFE182AEE" modified="2016-04-13" version="1">MFKHSNCQDLGTGDPVVTQIKFGVSQCVYPGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SQL3</accession>
    <name>A0A0E0SQL3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
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    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T21715</name>
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    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Nectriaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SQL3"/>
    <dbReference type="EnsemblFungi" id="CEF88726">
        <property type="protein sequence ID" value="CEF88726"/>
        <property type="gene ID" value="FGRRES_15643"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21715"/>
    <dbReference type="InParanoid" id="A0A0E0SQL3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF88726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="68" mass="7324" checksum="F967591F4F06BE1E" modified="2016-04-13" version="1">MTSEVDHNSRTNNLVIGATSAVSGFLNRSATVKDSATRRASRPPRGSSRRRLSDLSSPLSLSLMGFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YHH5</accession>
    <name>A0A1C3YHH5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FGRAMPH1_01T00873</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YHH5"/>
    <dbReference type="STRING" id="229533.A0A1C3YHH5"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00873"/>
    <dbReference type="eggNOG" id="KOG0273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YHH5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SCB64033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="663" mass="72170" checksum="4B664DE0C16A0318" modified="2016-11-02" version="1">MVAKEFLDSDRVNFLVWRFLLEGNYRETAAKFQKEWHVKQPHREFAFARHVKSHALVSVINRGLQYHALEREHARKLLSWAVLSDKDKLPKWPETDVIRYVQLPQDASAEEAEELHYGIFGPLDAHPQGRIEEDEEEDAEGEEVIEEELSRKRPQQISNGSPATKRQRLSNGLENGADAPAAVPVPASGPMIASTTGAGTAAATTAAPAPATTPMEIDNQPDNHAYPSPLEGEQAPEPMVRTDGPEQGTQVDKVEELAPETTFIRLMDDQNEGQGRGATPSPPSPSGPDNAPILLQCEWNPRDPSILAAAGTDALARVWSIARAGPVEPGQDHVSPQGHSLLDRDVPRDTTVTALSWTADGAAIAVATDSKNQASINVWSAEGAHLQSMEVSEPPIIKLSWNPINTALLAISPDKGGALVTVHYPPAGNSLSYLLSGHDIAATPLDAVWTGDAEFLLCGGDLMLCLQCTDTTIVQARKFETKEDDSFTQVLFDGRSRLAATSSDKGILDLWDESGQRRSISAHQGAITTMQWQPIPESHQGADDERLIATGGDDCAILIWNARMPKSKPKCFLTMDSPIMRLAFTPDGAFIAGATSTQVLIWKVGSHAVPRASWSRPVHPGWLSPKANTDADEEDEHCLCWDADGQKLAYGSNSRLAIINFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YHV2</accession>
    <name>A0A1C3YHV2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T02439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YHV2"/>
    <dbReference type="FunCoup" id="A0A1C3YHV2">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YHV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02439"/>
    <dbReference type="eggNOG" id="KOG4784">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YHV2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000151">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SCB64153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="290" mass="31645" checksum="BD4B926261DFDD2D" modified="2016-11-02" version="1">MGSPVGCRGCGSEFVSQGAINEWKDLPSENWAEMMEFWHCHKPHDHEHQDSESLATKGYGANSAISAQQGVGFVDLTSFLFTESDCRGLKYSSSTMDAGFDMSSLALEDDESNKFLHVFCRQCATEVGLYNVAASSVTLFKWQITCQTKTPDPNPSSPECLAATLMATISRSGSSKSIITPHVLGSVELSSAVARQNLHLWVLNPNVVYTASSTTGCTTAMKILYRHIDSEEGDKLITSMTSDVQEITLPETAIKAAEECLLASSQLLPAQERTFKEWNVGLLGRWEPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YI74</accession>
    <name>A0A1C3YI74_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T02421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YI74"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02421"/>
    <dbReference type="eggNOG" id="ENOG502SP07">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YI74"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
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        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SCB64151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YID1</accession>
    <name>A0A1C3YID1_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T03839</name>
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    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YID1"/>
    <dbReference type="STRING" id="229533.A0A1C3YID1"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03839"/>
    <dbReference type="InParanoid" id="A0A1C3YID1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB64272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="409" mass="44436" checksum="DB602CE140A3D7BF" modified="2016-11-02" version="1">MSPDHGSSRSRRGVWSHWVPLAVTLTVATVGVAAWVWSQRKDTEEEDDNGLDYSNHARGGDHQAYGSHDVGSRDIQGPEKPPRPDGQSHGIAHANEEATGGGWGSRVTGALRRTPSPQQFFDSTGKTVAAGVAAASAAMGKALASIREEDKSPFDDNNPWQEEEEAKNERAPADTSSQHIGGSRRRKTVAIVVSAETGAVPEEEDPFHEHASILSHIPRHIDHSKVKLFVLIYAPGLKEPAVDTANSNLPPPSLSSSFSNIGHDQVQTPAEESKNQFESGSPAFNSIYSQALGLVEKETMVLPFTTSNGHVHILRHLQPEVIYLQKALSGQDGSIITTLQTWLRHDVILIVGADGGSGGLADSESEAERSTKNKEWWQRSERVGRGRGVVVVDSMRLNDDWARRVQGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YIE7</accession>
    <name>A0A1C3YIE7_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="8">PPIase</shortName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FGRAMPH1_01T01953</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YIE7"/>
    <dbReference type="SMR" id="A0A1C3YIE7"/>
    <dbReference type="FunCoup" id="A0A1C3YIE7">
        <property type="interactions" value="682"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YIE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01953"/>
    <dbReference type="eggNOG" id="KOG0865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YIE7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000032">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF385">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="71"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SCB64120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="224" mass="24419" checksum="9A9478411CDD6893" modified="2016-11-02" version="1">MRPSLFKPLLPRHTCFSAARTSSSLPQLSNTIRSVRFFSATSAVMGNKVFFDISWEGPVFQNGKPTSEVKKQTGRINFNLFDDVVPKTAENFRALCTGEKGFGYEGSSFHRIIPDFMLQGGDFTRGNGTGGKSIYGEKFADENFTLKHDKPGLLSMANAGPNTNGSQFFVTTVVTSWLNGRHVVFGEVADEESLNVVKALEATGSGSGAIKYTQKPKIEKSGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YIF9</accession>
    <name>A0A1C3YIF9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FGRAMPH1_01T02099</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YIF9"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02099"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YIF9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF39">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="71"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="606"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SCB64130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="635" mass="68793" checksum="9EE66481FBF8D585" modified="2016-11-02" version="1">MISLVRKAIKAKQDREKTQLPSTSMEMQQTQHDVNKEQPQCRHMEAYESPNVKCASCASEKKAARVYRWKIIIGLMAPFALQSLDSTIIASALPWIAGDFGEISQLNWIVSAFNLTSAAFIPFWSQMADVFGRNASLNAAIILMLIGSALCTGAPTTAFPVLLLGRGFQGLAAAGLNVIVRTVLADKVSLQENAKNWAIFSLVGGISYGLGPVIGGYLTRADWRWCFGINLPIAVLALIVAFFVLHKELLGPQPIPELNETAETGRRTKFIARLKTVDFGGQLLFILGFGLVILAMTWGGATYPWSSPAVIVPLVLGIIFAGVFCYWEYLLAPGNMVAEKMPWQRAMIPWELISNRDIGLLCYCECATGVGMYAVLYFCNIYFIAVRGYDSDEAGVQLLYFVPGLGVGVYICSFMCNRWPRMTFPSVFLGTLTESVGLGVLAWAIWADRLSVIYGMMALVGCGSGMRFMASPLHGIGLFRHLRASVIGLMAVAIPFGGTVGLTIMSAVFNNTSGLGSSAGEFSHVKSKGAEANEQAKMGVVWAFVAVTPIVALAFPLSWCIGNVKLGQGPSGEDGPTDIIVKGSYLLKLLRGQEHLRVEKNGYRLNSSHSGAWSESAASDENTNASRRLQGSQQV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKE0</accession>
    <accession>I1S2J7</accession>
    <name>FGM3_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminotransferase-like protein FGM3</fullName>
            <ecNumber evidence="9">2.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">C64 cluster protein NRPS5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Fg3_54 cluster protein FGM3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Fusaoctaxin A biosynthesis cluster protein FGM3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FGM3</name>
        <name type="ORF">FGRAMPH1_01T20965</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2012" name="Plant Cell" volume="24" first="5159" last="5176">
            <title>In planta stage-specific fungal gene profiling elucidates the molecular strategies of Fusarium graminearum growing inside wheat coleoptiles.</title>
            <authorList>
                <person name="Zhang X.W."/>
                <person name="Jia L.J."/>
                <person name="Zhang Y."/>
                <person name="Jiang G."/>
                <person name="Li X."/>
                <person name="Zhang D."/>
                <person name="Tang W.H."/>
            </authorList>
            <dbReference type="PubMed" id="23266949"/>
            <dbReference type="DOI" id="10.1105/tpc.112.105957"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="e110311" last="e110311">
            <title>The Fusarium graminearum genome reveals more secondary metabolite gene clusters and hints of horizontal gene transfer.</title>
            <authorList>
                <person name="Sieber C.M."/>
                <person name="Lee W."/>
                <person name="Wong P."/>
                <person name="Muensterkoetter M."/>
                <person name="Mewes H.W."/>
                <person name="Schmeitzl C."/>
                <person name="Varga E."/>
                <person name="Berthiller F."/>
                <person name="Adam G."/>
                <person name="Gueldener U."/>
            </authorList>
            <dbReference type="PubMed" id="25333987"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0110311"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="922" last="922">
            <title>A linear nonribosomal octapeptide from Fusarium graminearum facilitates cell-to-cell invasion of wheat.</title>
            <authorList>
                <person name="Jia L.J."/>
                <person name="Tang H.Y."/>
                <person name="Wang W.Q."/>
                <person name="Yuan T.L."/>
                <person name="Wei W.Q."/>
                <person name="Pang B."/>
                <person name="Gong X.M."/>
                <person name="Wang S.F."/>
                <person name="Li Y.J."/>
                <person name="Zhang D."/>
                <person name="Liu W."/>
                <person name="Tang W.H."/>
            </authorList>
            <dbReference type="PubMed" id="30804501"/>
            <dbReference type="DOI" id="10.1038/s41467-019-08726-9"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2019" name="Toxins" volume="11" first="277" last="277">
            <title>Fusaoctaxin A, an example of a two-step mechanism for non-ribosomal peptide assembly and maturation in fungi.</title>
            <authorList>
                <person name="Westphal K.R."/>
                <person name="Nielsen K.A.H."/>
                <person name="Wollenberg R.D."/>
                <person name="Moellehoej M.B."/>
                <person name="Bachleitner S."/>
                <person name="Studt L."/>
                <person name="Lysoee E."/>
                <person name="Giese H."/>
                <person name="Wimmer R."/>
                <person name="Soerensen J.L."/>
                <person name="Sondergaard T.E."/>
            </authorList>
            <dbReference type="PubMed" id="31100892"/>
            <dbReference type="DOI" id="10.3390/toxins11050277"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 9">Aminotransferase-like protein; part of the Fg3_54/C64 gene cluster that mediates the biosynthesis of the octapeptide fusaoctaxin A, a virulence factor that is required for cell-to-cell invasiveness of plant host (PubMed:30804501). The 2 nonribosomal peptide synthetases NRPS9 and NRPS5 form an assembly line which likely utilizes GABA as a starter unit (loaded on the unique module M1 of NRPS9) and sequentially incorporates seven extender units composed of the residues L-Ala, L-allo-Ile, L-Ser, L-Val, L-Ser, L-Leu and L-Leu, respectively (PubMed:30804501, PubMed:31100892). During the process, each of the residues that are tethered on modules M3-M7 of NRPS5 containing an E domain can undergo an epimerization reaction to produce a D-configuration before the transpeptidation reaction occurs (PubMed:30804501, PubMed:31100892). The elongation of the peptidyl chain might be terminated by module M8-mediated L-Leu incorporation, followed by R domain-catalyzed 4 electron reduction to release the resulting octapeptide from the assembly line as an alcohol (PubMed:30804501, PubMed:31100892). Fusaoctaxin A is cleaved by the cluster specific ABC transporter FGM5 to the pentapeptide fusapentaxin A and the tripeptide fusatrixin A (PubMed:31100892). The other enzymes from the cluster, FGM1, FGM2, FGM3 and FGM9 seem not to be involved in the biosynthesis of fusaoctaxin A and their functions have still to be determined.</text>
    </comment>
    <comment type="induction">
        <text evidence="2 3 5">Expression is positively regulated by the cluster-specific transcription factor FGM4 and is induced during infection of coleoptiles of wheat seedlings (PubMed:23266949, PubMed:25333987). The fusaoctaxin A gene cluster is silenced by H3K27 trimethylation by the histone methyltransferase KMT6 (PubMed:31100892).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Produces fewer spikelets with blight symptoms on susceptible wheat cultivars.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="8">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="SCB64986" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="9"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64986.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKE0"/>
    <dbReference type="SMR" id="A0A1C3YKE0"/>
    <dbReference type="STRING" id="229533.A0A1C3YKE0"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T20965">
        <property type="protein sequence ID" value="FGRAMPH1_01T20965-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G20965"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20965"/>
    <dbReference type="eggNOG" id="KOG1549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_2_1"/>
    <dbReference type="InParanoid" id="A0A1C3YKE0"/>
    <dbReference type="PHI-base" id="PHI:9038"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586:SF21">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE (PLP)-DEPENDENT ASPARTATE AMINOTRANSFERASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000449948" description="Aminotransferase-like protein FGM3">
        <location>
            <begin position="1"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="282"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q96255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="23266949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="25333987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="30804501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="31100892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="25333987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="30804501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="30804501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SCB64986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="402" mass="43942" checksum="ED97C11777F52F47" modified="2016-11-02" version="1">MSSSSFSIENVRSQFPALEKRQIFGDNAGGSQVLGTVAKRQLSPITEYLIETNVQLGASYKTSTQSTAIFDNAYKAAAKYINAGIDEIVIGASTTQVFRNLAAALKLQPGDELILTNVDHESNIDPWLHYAALNNATIKWWTPSDLNNPKLDPEQLRSLLTNKTRLVACTHCSNILGTINNIKAIADVVHEIPGALLAVDGVAYAPHRAIDVKELGADFYAFSWYKVYGPHISLLYGSKAAQAQLSSLGHFFNPDGSLMDKLELAAASYELTQAIIPLTAYFGENPKQTWDAIAEHEQKLQTRLIEYLVSKPQITVYGETSTDKAVRVPTVSFTVEGMSSQSVVEAVEAVSHAGIRWGHFFSKRLVGSILGLSDDGVVRVSLVHYNTVEEVDQIIVALEMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKI1</accession>
    <name>A0A1C3YKI1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T19989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19989"/>
    <dbReference type="eggNOG" id="ENOG502RJ3B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YKI1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="411" mass="45840" checksum="AB935A634C0AC0F5" modified="2016-11-02" version="1">MPNPLKASYQFLAWMLDHDQVPNDIRRSLELVRTCDLDLQHLIELRNDCIHLLKRRPKVLQRVHTIIESAQKGLQEVCEIVEKCRPENDRGSRTTFSKRMAWVLVEASEFKSQEPIVSRHHAAVLAELNFLRQIALMAPIAELEEREEKRGTVVDATVFDNVALLGDLLGDLPTYAPEKKQPETQTIAPQPPIIVLNANTKPVARSEMPSPQVPAPLQHKPSSQILNIEHASDSLPEVLPVNITSVPPSRSLTTSSKYDTKDLVGLSLLLGDPLDFENGPTPSPEFQREGMKRATTVPAPYQASPYGPPRSQSVYSQPNQRFSYNPEDSVSDLSQSSRNSYRSSSTFSNISNPLHHRPSSLSVSSSATEAPIQQCHSCSNHYPSQFVWTNSSSTTISMASPYFHGNNFFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLN8</accession>
    <name>A0A1C3YLN8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FGRAMPH1_01T27101</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Forms homooligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YLN8"/>
    <dbReference type="FunCoup" id="A0A1C3YLN8">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YLN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27101"/>
    <dbReference type="eggNOG" id="ENOG502QW7A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YLN8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11855">
        <property type="entry name" value="SH3_Sho1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000213">
        <property type="entry name" value="High osmolarity signaling protein SHO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035522">
        <property type="entry name" value="Sho1_SH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF20">
        <property type="entry name" value="HIGH OSMOLARITY SIGNALING PROTEIN SHO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="261"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="206"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SCB65445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="320" mass="34739" checksum="B42A6CB0A02844E0" modified="2016-11-02" version="1">MPSYSLSSPSLQKMDNSRMYGQRKGIQMSNILGDPFALATLSISTLAWFITFVSCIIGRIQQNGDDDLAKNDPFPTFVWWSCIYCLCLITGVFVVIGSDAVHTYHVAVTGYLAAGIVLVSSSINQLLYSNSGAREAASAGFILLAMVIVIWTFYFGSNPSSTPRAFLDSFALAKESTTIHRSTMNAYGGRPETSNSVQPPQMYTSAQLNGFENPSPVGGIAGPRGSAVPQSYTNSGMQQQPPQSKPGHSPGNDTEVVPPTEYPYRAKAIYSYEANPDDANEISFSKHEILEVSDVSGRWWQARKESGETGIAPSNYLILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1R9E2</accession>
    <accession>A0A098CZ90</accession>
    <name>I1R9E2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG00077.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T00237</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF71918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315673.1">
        <property type="nucleotide sequence ID" value="XM_011317371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1R9E2"/>
    <dbReference type="STRING" id="229533.I1R9E2"/>
    <dbReference type="ESTHER" id="gibze-q4irt1">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF71918">
        <property type="protein sequence ID" value="CEF71918"/>
        <property type="gene ID" value="FGRRES_00077"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00077"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00237"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_0_1"/>
    <dbReference type="InParanoid" id="I1R9E2"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_3"/>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
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        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
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    </dbReference>
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        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="78"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF71918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF71918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="323" mass="35980" checksum="85351C9F5EC7011A" modified="2012-06-13" version="1">MFALDPINTAFYEQIKDLPCPHEMGGYQQAYDNLEQIQKHEPAADIETTTIQVGKKYGPTTVTLFRLKTHANKPLPMVFYTHGGGWIMGSAKSFAVLMEDLARRTKAAIVFPDYTRVPHQTFPYPLEQSYEVLDYMVNHASLYHILPGTIALAGDSVGGHMAITMVQLSLERKLPANIGQLVLWAPVTVTHKKLGSYTTFAQAPFLTEDSMDWMIDSFLPNPKDRETALASPLTHLSDKVLAQFPPTIIFLSTVDPLHDEGVAFGHRLQENGVDASIIKAEGQMHAFCLVKALRDGPTARAVMEMAALRLKRIFSQRDINGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1RA86</accession>
    <accession>A0A098D315</accession>
    <name>I1RA86_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG00413.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T01079</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316079.1">
        <property type="nucleotide sequence ID" value="XM_011317777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RA86"/>
    <dbReference type="STRING" id="229533.I1RA86"/>
    <dbReference type="EnsemblFungi" id="CEF72341">
        <property type="protein sequence ID" value="CEF72341"/>
        <property type="gene ID" value="FGRRES_00413"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00413"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01079"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009958_6_1_1"/>
    <dbReference type="InParanoid" id="I1RA86"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF72341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="393" mass="43681" checksum="AF64DABD1A2E1F5C" modified="2012-06-13" version="1">MSTNKPTKSFIVIGIDFGTTKIWSHAMDNIESKLGKELVQNSEFQVVVTLPAIWPPYARYRMEQAVEVSGIRSPRPCGNTTVCFISEPQAAALANMHDFRDTSTVKAGDTMVICDAGGGTVDLVNGMVESTDPFVVEEWVEGEGELCGGVFLDEEFLELIKGKVTLGSWPSLQRSDIRQESEAMKGHWPYKIEALIGHQINAVQKKCRRTTIYIVLVGGFGRSPYLFSRLKTTFNATVLRSKGDKPWTAICRGAVIYGINGHGPEASLGPEIDTRVALRSYGVLSDTLFRPDEHIGCEKYWSEDDQVWNGSYASCTESPPPKVWDSSMEPLCAIQWTGDINIELLPTQTTPLGKVLRKVVYVIEMNYEDGWADFTIYSQGMRVGAHHVNVELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1RB15</accession>
    <accession>A0A098D1A2</accession>
    <name>I1RB15_GIBZE</name>
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        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
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    <gene>
        <name evidence="5" type="primary">FG00716.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T01815</name>
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    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316422.1">
        <property type="nucleotide sequence ID" value="XM_011318120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RB15"/>
    <dbReference type="STRING" id="229533.I1RB15"/>
    <dbReference type="EnsemblFungi" id="CEF72708">
        <property type="protein sequence ID" value="CEF72708"/>
        <property type="gene ID" value="FGRRES_00716"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00716"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01815"/>
    <dbReference type="eggNOG" id="ENOG502QT8Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010065_0_0_1"/>
    <dbReference type="InParanoid" id="I1RB15"/>
    <dbReference type="OrthoDB" id="19806at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038919">
        <property type="entry name" value="STB2/STB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059025">
        <property type="entry name" value="STB6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011:SF2">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25995">
        <property type="entry name" value="STB6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STB6-like N-terminal" evidence="3">
        <location>
            <begin position="70"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="537"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="821"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF72708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="896" mass="99982" checksum="33CAA7F0DD8E3035" modified="2012-06-13" version="1">MAFRFPDPRLRVDDEFLTGTTVKGPVARTTTTSNSSTTRESPPNGILPIEVSAYNEATDAQPVPSPKRKNIVFADPFAFRYLEEGSNVVVVERRGVLRGYESYLVEQWACSRKPPTLLIVTYTGDEKHSVVVNVLSVPVDENLWPPRLKFYFDQLQDSHARPKDTELGELMVTNLSNFPSALTVIMVPEGDIRKYRSSFIVNEDLKRLGCSGRSGMTLSDPTEATQLKFLQLYKTSDRVPVAQAVVELIKLCQVTLYMFDKLGHQYIDGLLCDKTEMAINNWWIEVGAEHYNFEPTDGILGPSTVAALLGMFMGVRNRLHWYGEPVSKDVFDLESTKRGIGHFQKAQKLEKTRRLDRQTLLKLYAVSAKAAAGESWGVQRAVKSTLTEVGGKRGELVMGMVSGKDKGGLADIETLDIGTFASLAYGERAKWLWHGKPRRSPAEIPNHSPELNKTVPWKEDESNPNPKRVYSAPAETELDPKRLEDTTDVYVAHPSGSAVSIPDGSGDKEASKKNVFKSVAGKMSDARSGFGRIKDVVGGGLRGHANRPSVSTKDDFAGSDPRTSSSGLTTSLAQPPAPTQGVGRAFTWNNKPQEYLAAIKRADAEGVSTFPQLSHFASTSTVDIKAASAPIDPQKREMEGDLFDLGIKVRKGILSKAPSAVGSLVDESDLQGPFLEAELKDNISKKRLSRRHSIQLSHCPTKRVLNENRWPRRMSFSDAEEAVLEWEQLIDVTDATDDLSTLEAFNYLAHHFHQCMEEMKNGMGPWVCEKIKAIELLDDRFAKDKEELHALYYQLNEACQRMRISSHELLAEERSHLTEGLKEVEVLIARLDYEINALLQKVVDVEDGIVTFERQVEEMEKRAKDLKIHLETEGWFHWLFRTITGIGTGPDITRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RCK9</accession>
    <name>I1RCK9_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T03281</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317115.1">
        <property type="nucleotide sequence ID" value="XM_011318813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RCK9"/>
    <dbReference type="FunCoup" id="I1RCK9">
        <property type="interactions" value="405"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RCK9"/>
    <dbReference type="EnsemblFungi" id="CEF73445">
        <property type="protein sequence ID" value="CEF73445"/>
        <property type="gene ID" value="FGRRES_01328"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01328"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03281"/>
    <dbReference type="eggNOG" id="KOG2909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017554_3_0_1"/>
    <dbReference type="InParanoid" id="I1RCK9"/>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF73445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="393" mass="44064" checksum="DD5865F694D0A40E" modified="2012-06-13" version="1">MSTKYAFLSLPQSVFDSSDRDDAVSSLRGTISNDNGSVLPFNIPDFKIGTLDALVQQADELTKLEASCEAVVSKVADSLKNVLEGDEDRIAQYKMVNDKPTDQYVSTFSWNKIRYRADKSLAELISTLQKELANVDTDVKTKFNQYNSVKTNLAALQRRQTGNLSTKSLTPIVDPALLVQDSEYIETHLIVVPGNAKKDFLKGYETLAPMVVPRSAVEVAKDDEFVLYAVATFKKHSAEFLAKCREQKWTPRQFKYVEGGRQEEQRELDRVTNEERKVCGEALRMGRTGWSESVMIWIHVMTLRVFVEAVLRYGLPLDYVTALVKTTSKLAPKVKTALDSNYSYLGGNAFGRDKRGKITKDDAALSSEMAAAGFQTGEGHEYTAYVYYEIEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I1RCL3</accession>
    <name>I1RCL3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG01332.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T03289</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317119.1">
        <property type="nucleotide sequence ID" value="XM_011318817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RCL3"/>
    <dbReference type="FunCoup" id="I1RCL3">
        <property type="interactions" value="977"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RCL3"/>
    <dbReference type="EnsemblFungi" id="CEF73449">
        <property type="protein sequence ID" value="CEF73449"/>
        <property type="gene ID" value="FGRRES_01332"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01332"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03289"/>
    <dbReference type="eggNOG" id="KOG2038">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003417_0_0_1"/>
    <dbReference type="InParanoid" id="I1RCL3"/>
    <dbReference type="OrthoDB" id="28947at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="604"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="700"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="855"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="704"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="715"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="890"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="921"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="953"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF73449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="992" mass="110186" checksum="0BC271F8D09D5BE6" modified="2012-06-13" version="1">MAKPTKKGKGPRSSSKGPNLDKNALENLTSTLDKKLGKRKQPPTKAAGDQHQKRQRNTDNAAGDKKSGKIDEKTLLEEIKALGGDESDLALIQGIDSDDEENVKGSKDSKPADKGLKDELAAFSKQLGFAEVEMSEASDDEEGEEEEVEEESEGEEDDLEDIDDEEDDEDEVEAPKETAHKKGNMAFEPRADWHSAELRKLPTPTTDEPNPPRFAFDALKVHAQALLEEDATKYRTSVFAQSSHKFLSTIMSSGTLSDKVSALTLAVQESPVHNIRAFDALMSLASKKSRGQALGAIGALVDLLGPGSLLPSDRRLRTFHDQPGLVGTLQRSSGKPWAPGNALPGKITPAHLIVWIYEDWLKATYFKLIQVLEQLCSDEIEYSRTRALDFVYGLLKDKPEQESNLLRLLVNKLGDRDRKISSRASYLLLQLQNSHPGMKPIIVRMIEQQVLLHPSQDHRSKYYAINTLNQTILSSKEPAVAEALMRIYFDLFTIILKTGSLGISAPTDSKPKEKEKEKEEEKEEEKDPNDRRHPSRRPPRPRAGKPVKPVASEPETEAADKLVSAILTGVNRAAPFMVGNDTVMESHLDTLFKIAHSGNFNTGIQALLLIQQISSSRSIANDRFYRTLYESLLDPRLVNSSKHSLYLNLLLRALKNDVDSRRVKAFAKRMLQITGLHQPAFACGLLYVVGHLRETFPDISTLMDEPEEGDDDVDEKQKYDGRKRDPEYSNANRSCLWEVIPLQGHYHPSVTVYAAAILERNKKSLKPDLDSHSLIRFLDKFVYRNAKSTDSSKGVSIMQPLRASKDVGDIWLGSRAAGGATTAVNSSSFWKKKADEVAAEDVFFHEYFQQIDKEGKETKKKAKAGADVASDDEQEDEVWKALVSTQPGVDPDDDGSDVGFDLDDEDMASDDDDSPAMSLDGELDEDDDDMSVDIEGSDEEMGGALISEDEEGFEVKEAVSEKPKSKRRKLKDLPMFASVDDYAELLAGEEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1RCS8</accession>
    <name>I1RCS8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG01405.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T03453</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_011317202.1">
        <property type="nucleotide sequence ID" value="XM_011318900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RCS8"/>
    <dbReference type="STRING" id="229533.I1RCS8"/>
    <dbReference type="EnsemblFungi" id="CEF73532">
        <property type="protein sequence ID" value="CEF73532"/>
        <property type="gene ID" value="FGRRES_01405"/>
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        <property type="component" value="Chromosome 1"/>
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    </evidence>
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            <dbReference type="EnsemblFungi" id="CEF73532"/>
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    </evidence>
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    </evidence>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
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        <name evidence="6" type="primary">FG01480.1</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CEF73623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_011318987.1"/>
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    <dbReference type="AlphaFoldDB" id="I1RCZ3"/>
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        <property type="protein sequence ID" value="CEF73623"/>
        <property type="gene ID" value="FGRRES_01480"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03635"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="term" value="C:tRNA-intron endonuclease complex"/>
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        <property type="entry name" value="tRNA_int_end_N2"/>
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        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="452" mass="50944" checksum="B7AB724ED0241DB8" modified="2012-06-13" version="1">MAFDDDDNPHALAQPAGHANGAATEDADEDAPDYKLFLSMFDKHGVSSKAIRKGEKDFESHGTRAQDGLLEASRQVMDNVLGYTRIHREDAWVRGWCFPDWWAEVEQAGEKEGLWLHDRVVMVEHERGTWQKDIGRAMPGKIERLGTGRLWLLPEEAIFLVERGTMDLWWPSRQLEDILPHTNGKIKAGMGPDDYDVGLPLSLEAAYSLFIGNEGERGKLTLPQYQVYSNLKRAGFIVLRAPPYEAHTPTPQSKTLWQWMFSFFGSETQTTNRNPSGPLVQPGLYRAYRPIYDQLALLPRHKPLPTPPVVHPPEDPYRVFFHVWKSGGPPFSKKNPPPPNFRIAVVDAGNTCVPTLEEIEALLESTPHDPPNESWQGPGRMYQRLKHGHRNVLVAIVDRGLVNYMRFGEGAFGEERVFERFDNRGGQRGGKKMGRGGGRGRGGRGRGRGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I1RD64</accession>
    <name>I1RD64_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG01553.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T03787</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317364.1">
        <property type="nucleotide sequence ID" value="XM_011319062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RD64"/>
    <dbReference type="FunCoup" id="I1RD64">
        <property type="interactions" value="983"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RD64"/>
    <dbReference type="EnsemblFungi" id="CEF73699">
        <property type="protein sequence ID" value="CEF73699"/>
        <property type="gene ID" value="FGRRES_01553"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01553"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03787"/>
    <dbReference type="eggNOG" id="KOG1248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003753_1_0_1"/>
    <dbReference type="InParanoid" id="I1RD64"/>
    <dbReference type="OrthoDB" id="2192888at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="6">
        <location>
            <begin position="22"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="5">
        <location>
            <begin position="344"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="672"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1002"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1148"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1016"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1044"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1149"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1165"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1193"/>
            <end position="1212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF73699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1237" mass="136836" checksum="BCEFA9B53BE4EE77" modified="2012-06-13" version="1">MSTPSLAEKLDKIKSPGLQSQKKTVVVLQAVESTLKEQNTDPTPTGYFAALLALLQQANSNDNVNLELATPVVYLLDVVTPYAPQPLLRSKFTQILTLLAPLLLLQDAEAMLLRSSIGCLESLLLAQDAASWELSVSQIGPRRAVAGLLNMSLDHRPKVRRRSQEALKKVLRNPPPSPSLDHPAADMCAQTATKNLENLATQIAQARKGKKADGAHDPAMIHALQLVKTVAAASGGWPSKKIESLCELLLGIAKSGNEYMTMASFEIFEMIFEGMTDELSSAKLPRLMEIISELRPAANDTQLVPPWLAILSRGYDVSAQVEPDETFQNLPQLFDMVAQFLEAPSENIRISASECLVSFMANCIPQQVILEPSIYDEKILEKLAKSAESLLTVQFQAAWLQTFNVLGAIFDTLRWRSYPIMMNVTKTIGEIRENGSFRNKKDADEVIGKAIRAMGPEAVLSILPLNLAKPVKGQPGRAWMFPILRDYTSNTNLAHFKSEMIPLSEFMFQRVIDHGEAEKTMEIKIYETVVQQIWSILPGYCDLPLDLTQSFDQGFAEILANLLYKQVELRLDVCRALKTLIESNQAIADIEEQEENLVLQSRISRADAKKNLEYLSQFAGNMLAVLFNVYTQTLPQSRGPILQTINTFLSITPNAELMETFDRVSKMLATELQQEKPADKKKENQQKSKDHMPSTAQTLMDLVITMSVYLPRESFAALFEIAAVIINKEEEPQLQKKAYKLIPRLADSEIGKVALQERTAELQNLIVTSTEKVSAPARRERLAAIIALLPFISDASLHFIPSVLSEVVISCKENNERARETAYDLLVRMGQRMVEASGAAIDNSKVPHMPDDAPAGTANIEEFITMVSAGLAGSTPHMISASITAISRLLYEFRSALSDATLSDLVQTMDLFLTSNNREIVKSCLGFVKVCVIGLPVELMLPRLSTLVPNLIVWSHEHKGHFKAKVKHILERMVRRFGYDNIYKNCPDDDKKLMVNIRKTKERAKKKKDAAKGENDGEESDDDEDGPSKRQFENEYDQALYSSDSDDGDDSDDEDRPTKKAQKGGRTYIVEDDDEPLDLLDKKALANISSTKPVKMRKPTRTKAKVDLDGKLILGKDGDDEMEVDDANPEASGVGAYVAALKGKDVAKRGRGGKLKFSNRRSKDDEDDEMEMDENDVAAVKSRISPGRDRGSRGGFRGRGGRGGKSGRGGIAAGRKGLGVEKRHGASGVGKPRRGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RDN4</accession>
    <accession>A0A098D4R2</accession>
    <name>I1RDN4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG01744.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T04243</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317579.1">
        <property type="nucleotide sequence ID" value="XM_011319277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RDN4"/>
    <dbReference type="EnsemblFungi" id="CEF73928">
        <property type="protein sequence ID" value="CEF73928"/>
        <property type="gene ID" value="FGRRES_01744"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01744"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04243"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_0_0_1"/>
    <dbReference type="InParanoid" id="I1RDN4"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF73928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="375" mass="41750" checksum="3608541E58CD44AA" modified="2012-06-13" version="1">MVERSAEAGDSPEVAAHPSTASGPPATTTGETPADAPTSPAGDFHNPEHWASLTGGDVLEVDDADSAVGADIASSTESISSSILHYRTINGRTYHSERGNAQYWSPNDEHHNASMDIVHHLLCLSLDGKLHLAPLKDDIQTVLDVGTGTGTWAIDFADEYPNAEVIGTDISPIQPDWIPPNLKFEIEDCTQEWTFQPDFFDFVHMRYLYGSISDWPALFKEAYRACRPGGWVESHEASPRMESDDGSVTEGSAMNEWGKFFIEGGKKLNRTFEIIDKDLQIQGMKEAGFVDVKVWDYKAPIGGWAKDDRCREVGQFGQAALEQDYEGYVMYMANVALGWSREDVVLYCAQLRKEVRSGKFHPFYRQRVVYGRKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1RE33</accession>
    <name>I1RE33_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG01906.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T04601</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317755.1">
        <property type="nucleotide sequence ID" value="XM_011319453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RE33"/>
    <dbReference type="FunCoup" id="I1RE33">
        <property type="interactions" value="805"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RE33"/>
    <dbReference type="EnsemblFungi" id="CEF74107">
        <property type="protein sequence ID" value="CEF74107"/>
        <property type="gene ID" value="FGRRES_01906"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01906"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04601"/>
    <dbReference type="eggNOG" id="KOG3234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_7_1_1"/>
    <dbReference type="InParanoid" id="I1RE33"/>
    <dbReference type="OrthoDB" id="10264728at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000058">
        <property type="entry name" value="N-acetyltransferase (Nat5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF74107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="190" mass="22145" checksum="9E711BCB9EE53743" modified="2012-06-13" version="1">MATFRRFRPDDVNKFSKCNLDPFTETYELNFYLQYHAKWPSLFQVCEDMDGNIVGYIMGKVESSPDAYKFSEHYLPWHAHITALTVAPEARRSGIAKILTDQLEVAADAENAWFVDLFVRSSNHRAITLYKNLGYSVFRVVKDYYGDHATDPSKSSEDAFDMRKPMKRDKDHQHIRDDGENHLVNPEDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1REE9</accession>
    <name>I1REE9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG02037.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T04919</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317910.1">
        <property type="nucleotide sequence ID" value="XM_011319608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1REE9"/>
    <dbReference type="EnsemblFungi" id="CEF74266">
        <property type="protein sequence ID" value="CEF74266"/>
        <property type="gene ID" value="FGRRES_02037"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02037"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04919"/>
    <dbReference type="eggNOG" id="ENOG502SQB1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012207_0_0_1"/>
    <dbReference type="InParanoid" id="I1REE9"/>
    <dbReference type="OrthoDB" id="3692311at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="573"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF74266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="677" mass="74077" checksum="9A5464A11CD3D1A5" modified="2012-06-13" version="1">MRNMSILGAGKTSSHSLLVQTHDVRSDTFTEEASSWPNRPKTLDHGWKVVWLFPLVLIWVPFIDDKPISPHGDAVLEAIGLASTLWPIALAAILGALVRTVALFRAEQGTELGTLAILLGSQTLINTIKTAFVLRMLSVWTLVLFVLWTFSPLGGQAVLRTVRTKSHISSQEHKVSYIPAADIGPPLNYGLWESASNRGHQLGRIIPMFGAALSAPNALAQASNGSSERFNAVIQQLGGVEVASKDAKVDLWGNVRVPEITQLPGYNNSDPYNWVKVPPGQLATYESLIGIPIRGIPSNFAGNFTLQISASYMSLECSPWFNTSEWLSRIPNGLRSHETMNVSIVEEPVTELDSGTSHTYMDIPNGISENNTSFNFSSEDRYSMGPVERGTLVFGTRNNSTICDMSNVYVDVDIKCDRPRAFETMVCQALGVRHSRGYGVSVPNTNMTADRGTAPGAFISALPWLAQSFHFGDKSPFENYLADPALGMGDDSIGGYAVTTEFTRLSLKVFAQRLALVINTAMRVSYFAPAVLSFGKVNMTELENSMPGVYVTQYTNTTGDFITSEERYQVQKAWMAIYIVSLILMGISLLATVSLSLVTRAPDFLTSISALTRDSVHINVPAGGSTYCGDERATLLKNRRLKIRDVQPDKDIGYVALADDNGHENRGFKAAKKRLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I1REI7</accession>
    <name>I1REI7_GIBZE</name>
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        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG02076.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T05007</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317951.1">
        <property type="nucleotide sequence ID" value="XM_011319649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1REI7"/>
    <dbReference type="EnsemblFungi" id="CEF74310">
        <property type="protein sequence ID" value="CEF74310"/>
        <property type="gene ID" value="FGRRES_02076"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02076"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05007"/>
    <dbReference type="HOGENOM" id="CLU_2026940_0_0_1"/>
    <dbReference type="InParanoid" id="I1REI7"/>
    <dbReference type="OrthoDB" id="10297715at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF74310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="122" mass="13882" checksum="D3432021A08EBDCF" modified="2012-06-13" version="1">MVLRLCQIGSRYFSQAYSFGLCRHSYRSILLINCVIAMRYIPVSASFNHKIANFQYLKILLNLCVTPCFIDPSRTGAHKTHMAESRLILGTAAMTLLLTVERQETGVHSGRECGIVNSRDWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I1REK1</accession>
    <name>I1REK1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG02090.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T05041</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_011319663.1"/>
    </dbReference>
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    <dbReference type="STRING" id="229533.I1REK1"/>
    <dbReference type="EnsemblFungi" id="CEF74327">
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        <property type="gene ID" value="FGRRES_02090"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05041"/>
    <dbReference type="eggNOG" id="KOG0565">
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    <dbReference type="HOGENOM" id="CLU_005563_0_0_1"/>
    <dbReference type="InParanoid" id="I1REK1"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="PHI-base" id="PHI:5709"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048869">
        <property type="entry name" value="OCRL-1_2_ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047078">
        <property type="entry name" value="RhoGAP_OCRL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21310">
        <property type="entry name" value="OCRL-like_ASH"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="39"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="899"/>
            <end position="931"/>
        </location>
    </feature>
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        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF74327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="971" mass="107522" checksum="301CECB4001E1CEB" modified="2012-06-13" version="1">MAEENDQSPGSELGDPPSTTPQSLAKAVHARRSEFVRPHSLKVKIGTWNVAACTGTDKDLATWFTCGEGLDQQLTGLNLSKNSAVEKDAKDDGSSEPLHLTSGGDIGLYVLGLQEIVDLTTTKDYMNRAVYTDTSAIDRWRAALEAALPKGYELITAEQMTGLLLLVYASPEIAPTISNVSTKQVGTGLLGYFGNKGAVTTRLLLGETTRMVFVNSHLASGAGTSYLDRRCWDVGQILSRTQFDPIVHSGVEEDEGEKIGDEDLAFWFGDLNFRLDGLPGEDIRRILTLHARGEYGASEDESKSLGEQGVIVMKGSDSDDESSSRPSLHSRDESFDTASDLPDPDDFPEDPSQDPTSLQATIDSLIPHDQLRRIIKQRKLFHDGWKEGPITFLPTYKYDIGTVGLFDSSEKQRAPSWCDRILFRTRKDKQDYENKIKEEEEAKKKDEEMKSRGLEEDEDVLFSYDPDADGEDPSSSTDNLGYDEYDDNEELEAEELVTKEGFRDRIHLEIYTSHQRIASSDHKPITSIFTLDYDAVVPDLKAKIHAEVARELDRAENEGRPGITVVVEGSEGNEDKIVDFGEVLPLEKQTRHLTVANTGSVAATFSFVEKPTTDEGDDATPEWLKTSFLSADEEPQKSLGATVTLDPGETALVLLELQVSAVPHFRALNEARARIEEVLVLRVEDGRDHFIPVRGVWQPSCLGRSMAELIRIPDGGIRKFVQDKGIGGAIPYDSAVQCSAPKELFRLTEVVQTLVERSLAEATMLEEEVLPRDPGWPLESSTWRVGEDDMQDAKAKLVSALDSDGSLLDALPLEWPASFKLEVVCSILLLFLESLTDGLIPTHLWAKLSTSLPNVTSVPPTAWSDTKTQVLDILSMAPNHNIAFVFLTATLSRAASELTPVTTDPKPGLSRRLSFRRGNAQEEDSKKRKMREHRYAEIVGPMVCRIDEKEKGARDRARTVVEMFIMRDEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1RF98</accession>
    <accession>A0A098D6R8</accession>
    <name>I1RF98_GIBZE</name>
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        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG02367.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T05687</name>
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    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318278.1">
        <property type="nucleotide sequence ID" value="XM_011319976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RF98"/>
    <dbReference type="STRING" id="229533.I1RF98"/>
    <dbReference type="EnsemblFungi" id="CEF74648">
        <property type="protein sequence ID" value="CEF74648"/>
        <property type="gene ID" value="FGRRES_02367"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02367"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05687"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_4_1"/>
    <dbReference type="InParanoid" id="I1RF98"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF234">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF74648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="395" mass="44136" checksum="C7BEAAF6E5724A50" modified="2012-06-13" version="1">MTNSTERLDSKAIRIAPNELHIDDVKMYKEIYNQTATYTKQPDFYAGFGTPHSDKVEQLGKRIDKQNGPYNLFNAVRCTTVDIISHYCTGEPLGQLENSDENFNGDFLDAFDAVSVSLWKFMYQPVFRSLMFGIPASIAKIVSRDARLMIKLYGECHKSALNFKQNTPKSSHGTVFSSLSDLDEKDMGDEAVDLLIAGSDTTAYTLAVAVVQICQNTQVKKKLVESLNAGISDVKNLPSLLGLEQIAYLNATVREALRFAIAAPGRLPRVVPRDSKPLVIDDQVIPAGSIIGMSAYTMNFSKELWGKDAAEFNPDWWLGEDGKSLDTNMCSFSKGLRSCLGQNLAFAEMHYILAYLFAKYDMELVDKSDNIKVHDRFTTYVTNHAIMVDMKKHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I1RH98</accession>
    <name>I1RH98_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG03143.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T12165</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322623.1">
        <property type="nucleotide sequence ID" value="XM_011324321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RH98"/>
    <dbReference type="STRING" id="229533.I1RH98"/>
    <dbReference type="EnsemblFungi" id="CEF77886">
        <property type="protein sequence ID" value="CEF77886"/>
        <property type="gene ID" value="FGRRES_03143"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03143"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12165"/>
    <dbReference type="eggNOG" id="ENOG502QV67">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038720_1_0_1"/>
    <dbReference type="InParanoid" id="I1RH98"/>
    <dbReference type="OrthoDB" id="540611at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF9">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124210" evidence="2">
        <location>
            <begin position="20"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF77886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="389" mass="44260" checksum="C55816C77D9EB25B" modified="2012-06-13" version="1">MKYLLWAMLLSAVFAQAESSYLTRMADTMIAKGVSPDRGYQDAVLYLGFEKAYELSGDDKYLDWYIGQIAGPVVLEDGTIKGLNTSKYILDEYRMGHNYLYLYKETGHEKYKIAANTIRRMLDKYPRTPLGGFWHQQFFRNQMWLDGIYMADTFYAKWTSLYDRDNDTAWNDILLQYELIHEHTGNETTGLHVHGWVDGTASWADPKTGRAPNVWGRALGWYFMSLVEVLQFFPTSHDGYGQLHGYLESVALGLKESRDPASGSWWQVMNEPYPGRKGNFIESSGSSMFTWGLLKAIDLGYLDRSEYLDTARDAFTSIVSNFIEADEDGPIILNSTVAECGLLSSNVTFEYYVGQPTLDNGQNGVGPFMLAAYEWESWAKDAEAEVRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>I1RHJ9</accession>
    <accession>A0A098DJ98</accession>
    <name>I1RHJ9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG03256.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T12437</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322495.1">
        <property type="nucleotide sequence ID" value="XM_011324193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RHJ9"/>
    <dbReference type="EnsemblFungi" id="CEF78021">
        <property type="protein sequence ID" value="CEF78021"/>
        <property type="gene ID" value="FGRRES_03256"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03256"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12437"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_1"/>
    <dbReference type="InParanoid" id="I1RHJ9"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="37"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF78021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="280" mass="31313" checksum="E78A226939F2125E" modified="2012-06-13" version="1">MERSHTDTLPLANSVEIPQLGFGVYLSPPEVCVKSCLTALEAGYRHIDTAQYYGNEAEVGQAVQQSNVERKDVFLTTKILEAAGSVELSYSKCVESIGKLDPESGYVDLFLIHSPNPGAAKRKEMWQALERLYEEGKARSIGVSNFGIKHIDELKQYAKVWPPHVNQIELHPWLQQRDCVSYCEKNSIAVEAYAPLVRNQKANDKTLGSIASKHSVTPSKVLIRYCLQKNWIPLPKSDTPERIRDNADVFGFDLDDKDMKSLDNLDQGDTGAIVQAVDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1RHW3</accession>
    <name>I1RHW3_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T2</fullName>
            <ecNumber evidence="2">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG03379.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T12741</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the RNase T2 family.</text>
    </comment>
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        <property type="entry name" value="RNase_T2_His_AS_2"/>
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        <property type="entry name" value="RIBONUCLEASE T2"/>
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        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ribonuclease Rh-like"/>
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    </dbReference>
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        <property type="entry name" value="RNASE_T2_1"/>
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        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
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    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="RuleBase" id="RU004328"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF78173"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="255" mass="28097" checksum="E9B828868EDCDEF3" modified="2012-06-13" version="1">MTFTKALVPLALFLAKAQADAFSSCSKDLPLSCHNTTAVENTCCFVPAGQLLQTQFWDSSPVAGPSDSWTIHGLWPDYCDGTYPQFCDKSREYTDIKSIVSKFLGNSTLSYMDKYWVSQDGNDESLWEHEFNKHGTCISTLEPSCYSNYQTGEEAADYVKKTISLFKTLPTYKWLAEAGIEPSTDKTFTASEIEDALASQHGARVTIGCQGSTLSEVWYHFNVQGSIQEGQFVATEPDGSKSSCPSSGIKYAPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1RIB8</accession>
    <name>I1RIB8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG03549.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T13137</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322159.1">
        <property type="nucleotide sequence ID" value="XM_011323857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RIB8"/>
    <dbReference type="STRING" id="229533.I1RIB8"/>
    <dbReference type="EnsemblFungi" id="CEF78372">
        <property type="protein sequence ID" value="CEF78372"/>
        <property type="gene ID" value="FGRRES_03549"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03549"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13137"/>
    <dbReference type="eggNOG" id="ENOG502SNP0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095752_0_0_1"/>
    <dbReference type="InParanoid" id="I1RIB8"/>
    <dbReference type="OrthoDB" id="5220117at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF78372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="254" mass="28284" checksum="A82DAAD52BDD0BC6" modified="2012-06-13" version="1">MNSSWEVEFSTSRHVHNRGSRKPKSQTANISNIFGIYEIQCAKAENIALGHPSHANRKKHKRQSGPRLTIQSFTADEHGLVGTLHLPGVLDAEVHMSGSRKKLQEILDAENASDEEDSGSVEDLDTEYDNYQTGTESAATSSNADSPQHSEDANDSHGSEISTKEDRERSRFKKFEKNTFRQPKFWFFWKGAVLVLPDNNIQASPDTIPSPAPNEPQSGMGYIVFNGNGYKKFNGTISCDALEWRDVAISGRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RIX5</accession>
    <accession>A0A098DI60</accession>
    <name>I1RIX5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG03772.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T13673</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="EMBL" id="HG970333">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_011323613.1"/>
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    <dbReference type="EnsemblFungi" id="CEF78639">
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        <property type="gene ID" value="FGRRES_03772"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13673"/>
    <dbReference type="eggNOG" id="KOG0254">
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        <property type="entry name" value="LOW AFFINITY AMMONIUM TRANSPORTER"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023180"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF78639.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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    </evidence>
    <sequence length="525" mass="56805" checksum="0B433906A0320A80" modified="2012-06-13" version="1">MTMEAEKEQGLMPGSERDASDDNTLTGRDEEELSRTKTSASIADSFSLPREILFIAIICMAQFMTQGALGNCLNIIHVIGDSFGLKNPAELSWLIAGYSLTVGTFILFAGRLGDIFGYKRIFVIGFVWFAVWSMVCGLASYSNHVLFVFARVFQGIGPALTMPNGLAILGASYNPGAKKAIAFALFGACAPGGAVFGSAFAGLFVLGDPSWWPWAFYSFAIGLLFIALLASFIIPDPPHKLSSADLSWGEILGQLDLPGAVTGITALVLFNFAWNQAPIDGWDKPWVIVTLIAGVLMVPVFFYVELRVASHPLIPFDALTSDVAYILACIVCGWATFGIWVYYTWQFFQMVRGASPILSSAWMSPVAISGACASMTTAWLLHVSHPALVMLLAMGAFTTGTILMMTAPIEQSYWYQTFFGLIIMTFGMDMSFPAATLILSNSVKKEHQGIAASLVSTIVNYSISLGLGFAATVEVNINKGGESQADLLKGYRAAFYMGVGFAGSGFAISIVYFIKSMWRKKKVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJK1</accession>
    <name>I1RJK1_GIBZE</name>
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        <submittedName>
            <fullName evidence="9">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FGRAMPH1_01T14279</name>
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    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321632.1">
        <property type="nucleotide sequence ID" value="XM_011323330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJK1"/>
    <dbReference type="EnsemblFungi" id="CEF78942">
        <property type="protein sequence ID" value="CEF78942"/>
        <property type="gene ID" value="FGRRES_04023"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04023"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14279"/>
    <dbReference type="eggNOG" id="ENOG502RZDV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_7_1_1"/>
    <dbReference type="InParanoid" id="I1RJK1"/>
    <dbReference type="OrthoDB" id="5283415at2759"/>
    <dbReference type="PHI-base" id="PHI:5776"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="50"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF78942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="395" mass="44156" checksum="485151DE760204BF" modified="2012-06-13" version="1">MTDPKVTKAFEDGRVPKGITADYLNQSRDASAIAGIVFVTALTSIIVLGRLASRAFLMRRFGFDDGLTLISWMCFVAFVGLCIELIKLGSGRHFAYIEYVLDMPTVEYTEVLDFVAHIIYTTALLLCRMSGLAFYHRLCAVHDRLRLAISVVFGILIAGYIPQLLLIVFHCTPVTGLWPYEWQRGFEDYTCLQWGLVYSVNSSVSLICDFLLFGIPIVMLRVLEMPRKRKIQLGCILLPGISVIAISIVRLVLVIEGQWNTDMSWAYDPMLAIEVSEIGATLIALSIPGFKPLFDKVVLQRDITKGESNVKSKYEKQQSSKGGTALRSLNFRPEHDALTSRDTSAARTQVHRTSNATADNRSENSADGILVQVDFRIKEDIQDANSTSDPERAWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJQ6</accession>
    <name>I1RJQ6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG04086.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T14451</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321554.1">
        <property type="nucleotide sequence ID" value="XM_011323252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJQ6"/>
    <dbReference type="EnsemblFungi" id="CEF79029">
        <property type="protein sequence ID" value="CEF79029"/>
        <property type="gene ID" value="FGRRES_04086"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04086"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14451"/>
    <dbReference type="eggNOG" id="ENOG502T3GE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056593_1_0_1"/>
    <dbReference type="InParanoid" id="I1RJQ6"/>
    <dbReference type="OrthoDB" id="4973143at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF79029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="206" mass="24204" checksum="4B0ABCD901DC9E07" modified="2012-06-13" version="1">MVTFPTQKLQPYTLYITVAVPEEPPETMARRYDYEMEGVVEIRQKREDEGTVRTVLGSVDFDWGIYWHRDLGDGTWYTYEFCERAMWKGPPGLYKRWTYRRTDVKQSPRLHHHVVGLVQVMRIPDIGERITDFLDWLAPLVGDNTRRDDSFATTIYLQTRLFVASERKKVDKAAEHYDAAALVYELVHAAYPEVWYAFAGHLPRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1RK81</accession>
    <name>I1RK81_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-splicing endonuclease subunit Sen34</fullName>
            <ecNumber evidence="5">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG04275.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T14899</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="5"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321343.1">
        <property type="nucleotide sequence ID" value="XM_011323041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RK81"/>
    <dbReference type="FunCoup" id="I1RK81">
        <property type="interactions" value="151"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RK81"/>
    <dbReference type="EnsemblFungi" id="CEF79251">
        <property type="protein sequence ID" value="CEF79251"/>
        <property type="gene ID" value="FGRRES_04275"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04275"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14899"/>
    <dbReference type="eggNOG" id="KOG4133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049366_0_0_1"/>
    <dbReference type="InParanoid" id="I1RK81"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000008">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016690">
        <property type="entry name" value="TSEN34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017250">
        <property type="entry name" value="tRNA_splic_SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="9">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="8">
        <location>
            <begin position="199"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00059865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF79251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="285" mass="31395" checksum="41971DC1D9A84ED0" modified="2012-06-13" version="1">MAFPESPSVRISKIAGRYLVFDSEAAGFLRRNENINGVLVGTAPQQPTQNIFLGLPIELRPEEAESLLRKNVAYLVDDVAAHQAVLQNPSSEARRLYLDSLKTRKQTAQHVFAEKNAQRAAVAEKRVKPRRPAPPSNTEEDAIFASDQPEPIIRQQESAIKSMGVTPTSSGPLISSEAERVYQATNPTQGPLCGFLLTSGYYMTPGLRFGAKYSVYPGDPLRFHAHFMANQYDWDEEIPVLDIVAGGRLATAVKKAYLIGGRQPQTDESTDDGGMRTFSIEWAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I1RKB5</accession>
    <name>I1RKB5_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,4-alpha-glucan-branching enzyme</fullName>
            <ecNumber evidence="4">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycogen-branching enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">FG04313.1</name>
        <name evidence="14" type="ORF">FGRAMPH1_01T14985</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Glycogen-branching enzyme participates in the glycogen biosynthetic process along with glycogenin and glycogen synthase. Generates alpha-1,6-glucosidic branches from alpha-1,4-linked glucose chains, to increase solubility of the glycogen polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="4"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321302.1">
        <property type="nucleotide sequence ID" value="XM_011323000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RKB5"/>
    <dbReference type="FunCoup" id="I1RKB5">
        <property type="interactions" value="444"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RKB5"/>
    <dbReference type="EnsemblFungi" id="CEF79294">
        <property type="protein sequence ID" value="CEF79294"/>
        <property type="gene ID" value="FGRRES_04313"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04313"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14985"/>
    <dbReference type="eggNOG" id="KOG0470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011131_2_2_1"/>
    <dbReference type="InParanoid" id="I1RKB5"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000001">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000250">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000003">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="13">
        <location>
            <begin position="188"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CEF79294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="707" mass="80019" checksum="218BBC1B262C2EEC" modified="2012-06-13" version="1">MASIVKNSSNSLDPNQANGAAGDIPNDGTGVVKLDPWLEPFSGALKRRYSKAQDWIKTINAAEGGLEKFSRGAEKFGFNVDANNNIVYREWAPNATAAYLIGDFNGWNRGAHPMKKNDFGVFEITLPAQNGQAAIPHNSKLKISLDLPSGEHVDRLPAWIKYVTQDLSVSPAYDARFWNPPASETYKFKNSRPKKPASARVYEAHVGISSPEQKVASYKEFTKNMLPRIKALGYNVIQLMAVMEHAYYASFGYQINNFFAASSRYGTPEELKELIDTAHGLGITMLLDVVHSHASKNVLDGINEFDGTDHQYFHGGGKGRHDQWDSRLFNYGHHEVMRFLLSNLRFWMDEYQFDGFRFDGVTSMLYVHHGMGTGFSGGYHEYFGSDVDEEAVVYMMLANEMLHQLYPEVITIAEDVSGMPALCVPLSLGGIGFDYRLAMAIPDMWIKILKEVKDDEWDIANICHTLTNRRHGEKTIAYAESHDQALVGDKTLMMHLCDAEMYTHMSTLSPLTPVIDRGMALHKMIRLVTHGLGGEGYLNFEGNEFGHPEWLDFPREGNNNSFWYARRQLNLTDDPLLRYKFLDNFDRMMNQTEAKYGWLSAPQAYISLKHEGDKVIVFERAGLVFIFNFHPTNSFSDYRIGIEVPGTYRVVLNSDHGDVGGHNRIDENTRFFTTPMEWNNRKNWTHVYIPSRTAIILALESTVTQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RKK8</accession>
    <name>I1RKK8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG04419.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T15243</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321186.1">
        <property type="nucleotide sequence ID" value="XM_011322884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RKK8"/>
    <dbReference type="STRING" id="229533.I1RKK8"/>
    <dbReference type="EnsemblFungi" id="CEF79422">
        <property type="protein sequence ID" value="CEF79422"/>
        <property type="gene ID" value="FGRRES_04419"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04419"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15243"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009958_6_1_1"/>
    <dbReference type="InParanoid" id="I1RKK8"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF82">
        <property type="entry name" value="FAMILY CHAPERONE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G08575)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF79422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="636" mass="71077" checksum="E32B63EBC4F53874" modified="2012-06-13" version="1">MSLNLPIRQSTSSQRNRESRNNYFNSYTPPSSTEAINGPVRELVREQTPLNDRLIVGVDFGTTFSGVAAVYTSTPDDIEIIKTWPGGNGITSDKVPTEIAYSYPPNAPQGTEPTVKWGFQFKPEESRLRCIKLFLDRSQKLPFYVSPLDTAAQLKRFNKNVVDAVSDYLTQVYKHTMDTLTRRYGESFMASTKVEFVLTCPAVWSDAAKNTTLQAAERAGMGSRSEIQMISEPEAAAVYTLKAIQPNHLNVGDNFIVCDAGGGTVDLIAYKIISLKPLRVEESAVGTGGLCGSAFLNYRFEEHVRGRLGQTRFDEMKSKKGKTWQMGLRYFEEFVKRNFNEDEHQEVNVPFPGLPDDEEAGLDSGFLVMTAEQVKDIFEPVVKEVCDLVQGQVSGLRSKGGIVSGIVLVGGFGQSDYLYRRLKSHFTSAAPPPYSERPTHANANSTQETGSIEVMQPVYAWTAVVRGAVLRGLEGNMVISRKSRMHYGTSYATVYDEDKHSVSERYWSPLWERWMVSDRMQWHIAKGEALSPLAPIAFHYTRNFRPGQSLIVTDDLIACDADEPPAAYTRDLIHVCTLTTDLNAVPRSLFTRLTTTRGVEFDNLDFTLEMRVESAGLGFELKVDGVRYGRVEAEFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1RLK6</accession>
    <name>I1RLK6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG04810.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T16367</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF85892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323260.1">
        <property type="nucleotide sequence ID" value="XM_011324958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RLK6"/>
    <dbReference type="EnsemblFungi" id="CEF85892">
        <property type="protein sequence ID" value="CEF85892"/>
        <property type="gene ID" value="FGRRES_04810"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04810"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16367"/>
    <dbReference type="eggNOG" id="ENOG502SRIH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042688_2_0_1"/>
    <dbReference type="InParanoid" id="I1RLK6"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF85892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="267" mass="31034" checksum="B7FA08EB2963894A" modified="2012-06-13" version="1">MEQPQSVQAAIAYMKPDDELFRKEKPYVSLVPFLAKGANFTNTEVDEHTMEIKNVRGRESEFDLDKNGFSYVLYQPKERPGHDVQSPDHPYMKEISEFLKSYLGAQDVTPYDANTRKVGDPEFLQASLYAHVDHSIPNCKWRVQQLMAEKGKQMPKRWELINIWVPIKGPVRGSPLAVCDYQTVCRDDLVAVDSVFPHRVMEVYHVKHNPSHQWYYMEDQNVDDLLILKSWDSQEDKACCCIHTAIIPDPQVKTVRESIEIRFIVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>I1RMT4</accession>
    <name>I1RMT4_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG05281.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T17523</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323792.1">
        <property type="nucleotide sequence ID" value="XM_011325490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RMT4"/>
    <dbReference type="FunCoup" id="I1RMT4">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RMT4"/>
    <dbReference type="EnsemblFungi" id="CEF88778">
        <property type="protein sequence ID" value="CEF88778"/>
        <property type="gene ID" value="FGRRES_05281"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05281"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17523"/>
    <dbReference type="eggNOG" id="KOG0372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_8_1_1"/>
    <dbReference type="InParanoid" id="I1RMT4"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="PHI-base" id="PHI:5729"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901525">
        <property type="term" value="P:negative regulation of mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="114"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF88778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="320" mass="36215" checksum="26439E17C16F44EB" modified="2012-06-13" version="1">MPGLPSSVDLDECISRLYNKELLAESVIEAVCAKTKELLMRESNVVHVRAPITVVGDIHGQFFDLIEIFRIGGYCPDTNYLFLGDYVDRGMFSVETISLLVCLKLRYPNRVHLIRGNHESRGVTQSYGFYTECSRKYGNANVWHYFTDMFDFLTLSVVINDQIFCVHGGLSPSIHSIDQIKIIDRFREIPHEGPMADLVWSDPDPERDEFSLSPRGAGYTFGAQVVKKFLAVNNMSHILRAHQLCQEGFQVLYDDRLSTVWSAPNYCYRCGNMASVLEVSDTGERFFNVFAAAPENDVHKDLQPGNEKSADGNALPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I1RN21</accession>
    <name>I1RN21_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG05382.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T17771</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323907.1">
        <property type="nucleotide sequence ID" value="XM_011325605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RN21"/>
    <dbReference type="STRING" id="229533.I1RN21"/>
    <dbReference type="EnsemblFungi" id="CEF88267">
        <property type="protein sequence ID" value="CEF88267"/>
        <property type="gene ID" value="FGRRES_05382"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05382"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17771"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_1"/>
    <dbReference type="InParanoid" id="I1RN21"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08284">
        <property type="entry name" value="FDH_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF2">
        <property type="entry name" value="DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="14"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF88267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="354" mass="38553" checksum="9D1031B4480981B5" modified="2012-06-13" version="1">MSLPSTMKAVVFDGLYKISVQDRPVPQIRDGRDIIIKVHAAGLCGSELHIYRGHQPSGTGFIMGHEFTGTVVQVGSDVKTIHIGDKVVAPFTASCGNCFFCNNGCSARCVESQLFGCEILNGGQAEYVRIPMADGTAVKAPETISDEALLLMADIFPTGFYGVKSAMELVPSQNIQEATMVVVGCGPVGLCAILAATHFKPRHLFAIDSVESRLEQARKLGAEPLNFETDRAGLEARIREVTEGRGADMVVEVVGQAPALRTAFDIVRPFGAISSIGVHNKEIPWTGDDAYTRNIRVQMGRCPVRSVFNEALHLLEQKQDKIGFLFDHKMPLAQAPEGYTLFEQRKTQKVVFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>I1RNM9</accession>
    <name>I1RNM9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG05612.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T18329</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324172.1">
        <property type="nucleotide sequence ID" value="XM_011325870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RNM9"/>
    <dbReference type="EnsemblFungi" id="CEF87903">
        <property type="protein sequence ID" value="CEF87903"/>
        <property type="gene ID" value="FGRRES_05612"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05612"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18329"/>
    <dbReference type="eggNOG" id="KOG0768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_3_0_1"/>
    <dbReference type="InParanoid" id="I1RNM9"/>
    <dbReference type="OrthoDB" id="250329at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="88"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="196"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF87903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="316" mass="33920" checksum="33BBF49682FC1A4A" modified="2012-06-13" version="1">MTDIYIAGAIAAFTVDVLIYPLDTIKTRMQSQDYIKTYSESSQKNIWAIRGLYQGIGSVVLATLPAAGLFFSTYESAKRVIGNATPLPQPLVHSAASGFAEMASCLILAPAEVIKQNAQMLQNDSRGSSKPGSSTSLQAFRQLAGDGASRRLFTGYTALVARNLPFTALQFPIFEHVRSTYWTSRGPGTSDPGLIETGLVTGLSAGSAGSVAAFITTPSDVVKTRMMLSAGNQNESSTQGQSEVAAKMEGKRPKKGAWTVSKEVYQERGVRGFFRGAALRSGWTMLGSGLYLGSYEMAKVWLRRGKPDAEDDDTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I1RNP7</accession>
    <name>I1RNP7_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG05631.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T18373</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324194.1">
        <property type="nucleotide sequence ID" value="XM_011325892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RNP7"/>
    <dbReference type="FunCoup" id="I1RNP7">
        <property type="interactions" value="1030"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RNP7"/>
    <dbReference type="EnsemblFungi" id="CEF86961">
        <property type="protein sequence ID" value="CEF86961"/>
        <property type="gene ID" value="FGRRES_05631"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05631"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18373"/>
    <dbReference type="eggNOG" id="KOG0174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_5_2_1"/>
    <dbReference type="InParanoid" id="I1RNP7"/>
    <dbReference type="OrthoDB" id="7854943at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000010">
        <property type="entry name" value="Proteasome subunit beta type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF86961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="229" mass="24873" checksum="2D0A313917578A28" modified="2012-06-13" version="1">MEFGNAGVLNEDGIHVDMDRLKKGEVNLGTSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDTIWCCRSGSAADTQAVADIVQYQLGLFAMTNGKPPMTQTAASIFQEICYANKDRLSAGLIIAGWDERFGGQVYSIPLGGSLHKQSYAIGGSGSTYIYGYCDANWREGMEKDDAVNFVKGALREAIKWDGSSGGVIRMVVLTKEGADRHLYLPDTDYAVRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>I1RNY7</accession>
    <name>I1RNY7_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">FG05734.1</name>
        <name evidence="19" type="ORF">FGRAMPH1_01T18637</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="20">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="21">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="20">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="19 21" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="19">PH-1</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324316.1">
        <property type="nucleotide sequence ID" value="XM_011326014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RNY7"/>
    <dbReference type="STRING" id="229533.I1RNY7"/>
    <dbReference type="EnsemblFungi" id="CEF86044">
        <property type="protein sequence ID" value="CEF86044"/>
        <property type="gene ID" value="FGRRES_05734"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05734"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18637"/>
    <dbReference type="eggNOG" id="KOG0201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_2_1_1"/>
    <dbReference type="InParanoid" id="I1RNY7"/>
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    <dbReference type="PHI-base" id="PHI:1181"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000488">
        <property type="entry name" value="Related to severin kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="21"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="348"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="511"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CEF86044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="676" mass="75366" checksum="C161952857975B6C" modified="2012-06-13" version="1">MADREHDIEEGNEALDPELLYSKEYCIGGGSFGKVYKGVDKRTGQSVAIKVIDIESAEDEVEDIIQEIAILSELQSPYVTKYYGSYAKGAELWIVMEFCSGGSCADLMKPGLISEDYIAIIVRELLMGLDYLHTDKKLHRDVKAANVLLSSNGQVKLADFGVSGQLSATMTKKNTFVGTPFWMAPEVIKQSGYDHKADIWSLGITALELANGEPPYADIHPMKVLFLIPKNPPPRLEGNFTKAFKDFIESCLQRDPKDRPTAKDLLRHPFIRRAKRTTYLTELIERHSRWAAAHKGEDDDNWESVNDGRPPAEHERVDEDMWDFGTVRLVGDRGGIVNRPGLNILDENATNARASRPLESEEDYGEQRREASPMKRDFALQPLETVKAPNSRQSSPQRKAVPQSQYQPPLSPTRALPQTPLKLPARDSADTPRPLRSVHAPVPESPEYDRELQNELQRDIGMLNLGYDPKESRSPQPQPSQRPPAPPAHLTRPTTTKQMSLPEIPPYRPSQAVSQQRLPSLQHASTPQVLVPLPGGAQGPRPLPSKNSPSPSDFTAPSAFPTPSPANPNGELDALNDVIFPALEEALKRRQINLQQVYKPGQNPAQIPPQQQRAEAAHEKLRKLVYKLAHVCKEIDHYDKAEPVGMGREVGSFLEGLLEEILVRVEPLDEDEDVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1RP90</accession>
    <accession>A0A098DZD4</accession>
    <name>I1RP90_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG05847.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T18907</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324448.1">
        <property type="nucleotide sequence ID" value="XM_011326146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RP90"/>
    <dbReference type="SMR" id="I1RP90"/>
    <dbReference type="FunCoup" id="I1RP90">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RP90"/>
    <dbReference type="EnsemblFungi" id="CEF86739">
        <property type="protein sequence ID" value="CEF86739"/>
        <property type="gene ID" value="FGRRES_05847"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05847"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18907"/>
    <dbReference type="eggNOG" id="ENOG502S2CW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021264_11_3_1"/>
    <dbReference type="InParanoid" id="I1RP90"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 8" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124423" evidence="9">
        <location>
            <begin position="19"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="10">
        <location>
            <begin position="33"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="11">
        <location>
            <begin position="111"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="10">
        <location>
            <begin position="348"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="10">
        <location>
            <begin position="410"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="428"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF86739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="454" mass="48932" checksum="0FF6719D243A54F1" modified="2012-06-13" version="1">MKGSFASLVALLAVNVVATPSFRNIFGLEKRQAGRCGTGFGGVCAANECCSSAGWCGTGYLYCSAPACQIEYGPGCDANVRPTGPDTTNVARPKVGSIPYGQAIYRCNRNGDIAITYDDGPYTYTEDLLDLLQPQRYNVKATFYITGRNLGKGAINDPATPWPGLIRRMIRDGHQIASHTWSHQRLTTLSRAKFWNQMIFNEIAFADILGYFPTYMRPPYSASNATTDAWLGELGYHVTYFNLDTEGYLHDSPNTIGTSKQIWDTTVEGKSPASNKWLHIEHDPVYQSVYNLTEYMLKSLARNNFRGVTVGECLEDPKANWYRSVTPSSASTTTTAATSSATFPLTTNGRCGSRHGGATCRGEFNGETCCSQNGWCGSTDAHCGRGCQPVFGTCSGVSEPAGPEPTATNPGRCGSAFGGKKCDQWDPCCSRAGWCGTSSDHCGSGCQSAFGTCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RPH2</accession>
    <name>I1RPH2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG05941.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T19123</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324551.1">
        <property type="nucleotide sequence ID" value="XM_011326249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RPH2"/>
    <dbReference type="EnsemblFungi" id="CEF88721">
        <property type="protein sequence ID" value="CEF88721"/>
        <property type="gene ID" value="FGRRES_05941"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05941"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19123"/>
    <dbReference type="HOGENOM" id="CLU_927641_0_0_1"/>
    <dbReference type="InParanoid" id="I1RPH2"/>
    <dbReference type="OrthoDB" id="5078661at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF88721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="300" mass="34665" checksum="BC8B4FC5C6DC56D4" modified="2012-06-13" version="1">MSHRRQRLIEQRLTDLRDRIDRADPEDVTSLTDLLELLGDAPPRIVETAPTSPARDIPSTPISREPSDFQIRDAPHRIMDIAPTSPVRDTPLMSRSRGSLDFGTGEMLCFHNSALCKDMTQALHNLLAKERRGRAPQQYSILQRYHVVKIESRTPSLGHSMRWENCDRTPGVGSCHDDLRCFNPNECAVNYVNRFCLDRDVFRRYNIECEQANRVFNVYKSQLPPRYAQGCSNAVTNMFCSLFIDSHDIDDVDDWDPRVHGVLSCNYLDSYQKFANDFYFEIMATRARGNMREFHAGRWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQ06</accession>
    <name>I1RQ06_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG06139.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T19583</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
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                <person name="Park J."/>
                <person name="Park S.Y."/>
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                <person name="Regev A."/>
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                <person name="Wapinski I."/>
                <person name="Yoder O."/>
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                <person name="Zeng Q."/>
                <person name="Zhou S."/>
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            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>PH-1</strain>
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    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQQ5</accession>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Nectriaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
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    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325066.1">
        <property type="nucleotide sequence ID" value="XM_011326764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQQ5"/>
    <dbReference type="STRING" id="229533.I1RQQ5"/>
    <dbReference type="EnsemblFungi" id="CEF86167">
        <property type="protein sequence ID" value="CEF86167"/>
        <property type="gene ID" value="FGRRES_06402"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06402"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20219"/>
    <dbReference type="eggNOG" id="ENOG502SIXR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014181_0_0_1"/>
    <dbReference type="InParanoid" id="I1RQQ5"/>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF86167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="418" mass="46439" checksum="1E11731DCE4896D7" modified="2012-06-13" version="1">MAPLILHNVPDDECYVGDDGIKRPYAMYFNQQDAPQGTTRSRRSAAESGSFGKSTRRSRSRTGTPARSRENPTLAAADKLFGDWVSNQAAAPAQTVQRKSSGMMQEEAATQRPVTSTPVELILRGYRSYTQQYATISHYESLAGAILEDYPREPPASQRRYKSELRDPAFTRRRNLTADERALVNRADGGDHWVKVTFESREAAEAATFASPQRILGHLVYAEPYRGVPPTKDEACPDIEVVPDHPRSQSMPTVPTTNGRKNFSGPTSFNSRLLDLSPPHSQSSSLTMDTGTISSSHASSATITEPLPLPKATTSSIEPMEIRDEDSIFCRRIPTARRATILPAEQALLPQQTMMQRVINAIPFIKWFGGSMIGNEVPRTETGEFDWSKASLYWKLIWWLDAWIGLFGGDVLNADKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQX7</accession>
    <accession>A0A098DQ03</accession>
    <name>I1RQX7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG06478.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T22377</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326079.1">
        <property type="nucleotide sequence ID" value="XM_011327777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQX7"/>
    <dbReference type="EnsemblFungi" id="CEF83427">
        <property type="protein sequence ID" value="CEF83427"/>
        <property type="gene ID" value="FGRRES_06478"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06478"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22377"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015676_3_0_1"/>
    <dbReference type="InParanoid" id="I1RQX7"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="204"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF83427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="634" mass="70095" checksum="95E77FBFE970A8D1" modified="2012-06-13" version="1">MTEHPKRNKTRVADLASGFPHVPPFDGEESLDKSQIASAFIDEFSSAVTSADWDKFADLFVEDAWWRDALTLTFDKRTIHGRSAIQSAWKTLSENHNRKPSEFSDNPTGIWGMAPQYMRFSPALACLDVPFGFCTEEPRSKCVGQAKLVRVDGKWLIWILSTAVQELIDHPFEQLPRLSESSIGSSQRGKPSAQGLPNVSGVLDAVVIGGSSSGLANTIMLDAAGADVAVFDVELEAGGNWSTSRYSSVVLHHNRSMVQLPMFPIPPDSYPEYMGGKDLTRYMSSAVEQLNLPFFGGIQVVGSAWHEDAQYWTIDLKDIQSSNTSTIKAKNLVLSNGFLISKANTYIPPLQGREKFQGPAQHTSEYRDATLYKDLDVIVVGSGNSAHDVAKDLALNGVKSVTILQRSPTTLLDFDIFISIVSMRYQGQMPVEAADFQENSLPLGIMRDMASGLMSSLSQTMEPRHKLLQEKGYQIEKQVCLPCRAFEERGRSIYIDQEKVFDLVLSDRIRIAKGEAKGLTEQGLVVYDEAEDKSKTIPAGGIVFATGYKNEDLPKKYADAGFIDRESAGKLANVCAPCVDEEGEPPGYVTYSGHPHLYFAGIGFWMCRWISRYVAVQVMADVTGTFPERYARDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RRI1</accession>
    <name>I1RRI1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG06703.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T22957</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326338.1">
        <property type="nucleotide sequence ID" value="XM_011328036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RRI1"/>
    <dbReference type="FunCoup" id="I1RRI1">
        <property type="interactions" value="352"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RRI1"/>
    <dbReference type="EnsemblFungi" id="CEF84156">
        <property type="protein sequence ID" value="CEF84156"/>
        <property type="gene ID" value="FGRRES_06703"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06703"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22957"/>
    <dbReference type="eggNOG" id="KOG3445">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117700_1_1_1"/>
    <dbReference type="InParanoid" id="I1RRI1"/>
    <dbReference type="OrthoDB" id="88at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000173">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF84156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="137" mass="15099" checksum="15F5B774DA810F17" modified="2012-06-13" version="1">MTVKALRQIAKGQNGLGAFILQCKKLDFYYCDWAGSSKGMNGFIKSLLPKFAAANPQVEFAISPRPGKHPVIIGHYINGLHKPICVRNLSPYEILKKAELLRDASGEKLKKHNQAVTSTRPSVRGVWSPYHGKGTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>I1RRQ4</accession>
    <name>I1RRQ4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">FG06789.1</name>
        <name evidence="14" type="ORF">FGRAMPH1_01T23193</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326440.1">
        <property type="nucleotide sequence ID" value="XM_011328138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RRQ4"/>
    <dbReference type="FunCoup" id="I1RRQ4">
        <property type="interactions" value="994"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RRQ4"/>
    <dbReference type="EnsemblFungi" id="CEF84509">
        <property type="protein sequence ID" value="CEF84509"/>
        <property type="gene ID" value="FGRRES_06789"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06789"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23193"/>
    <dbReference type="eggNOG" id="KOG2026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016848_2_1_1"/>
    <dbReference type="InParanoid" id="I1RRQ4"/>
    <dbReference type="OrthoDB" id="10263353at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000068">
        <property type="entry name" value="U4/U6.U5 tri-snRNP-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="13">
        <location>
            <begin position="74"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="196"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CEF84509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="534" mass="61573" checksum="B2F936C91854F162" modified="2012-06-13" version="1">MSKRQASEALEDIASPASKRSRLDFDTPEPGTEELINETNTNGNAQEVDDDDDFDDQETIPAAPIRQSAPTEGYDDLYLDTIDRNVLDFDFEKLCSVSLSNINVYACLVCGKYFQGRGPKSHAYFHSLDEDHHVYINLESQRVYVLPEGYEVKSRALEDIKYVADPRYTKKEVIEMDRTRRTSQTLDAKEYIPGFVGMNNIKENDYFNVVVQALAHVAPLRNYLLLEDFSSKTELVKRASILVRKIWNPRAFKAHVSPHELLQEISLRSNKRFNLTLQSDPVDFLSWFLNNLHIGLGGSKTKPGSSMIQRTFQGKMKIESQAITARADATDRLRFEDADVKVDIVRFLLLTLDLPSTPLFQDELEKNIIPQVPLTTILTKYDGQRAQEHHAQRKRYRLMHPLPPYLAFHVKRFSQNKFVSERNPTIVTFDARNLDMSPYVEPNPKEWPPGEPIWYDLVANVVHEAVRTREDVVDSGEERKTWKVQLKNKATGEWVVCQDLYVDKVQSELLYLGETYLQIWERRREPNKGKGRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1RU70</accession>
    <accession>A0A098DWB5</accession>
    <name>I1RU70_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG07754.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T25571</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327567.1">
        <property type="nucleotide sequence ID" value="XM_011329265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RU70"/>
    <dbReference type="STRING" id="229533.I1RU70"/>
    <dbReference type="EnsemblFungi" id="CEF85644">
        <property type="protein sequence ID" value="CEF85644"/>
        <property type="gene ID" value="FGRRES_07754"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07754"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25571"/>
    <dbReference type="eggNOG" id="ENOG502S8FX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031555_1_0_1"/>
    <dbReference type="InParanoid" id="I1RU70"/>
    <dbReference type="OrthoDB" id="5326346at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="171"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF85644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="415" mass="46896" checksum="BBF4EAF3AE1F09C5" modified="2012-06-13" version="1">MAHGNSSSEHVSIQGGLENKVGSKKPSTYIFHSNGDTQLSLTTCIDKTFIWESERIWIGEEKLRKKQLETEEKKKKKKKKKFSLPPPPPPPQESPISIPTSFDDTTDPLSSFPGLTHSRPGLSDAEATDPGPSDAGKNTDSSSLQASNYGERSTNLPGQVEIRMLVSGTHLVLASSYFEKMFSGPFIEGKADHRSGLRQVTASDWDPKAFNIVLTVIHGYHRDVPRSLDLEMLAKVAMIVDYYKCHEIVELYAEIWIGRLQSEVPTIYGRDCILCLFVSWVFSQPEMFQAMTQLALRHSGKMIEAGDIPIPSNILDQINEARLNYLDTMSTATYDLLDRLQGEEVECSYECSAMLLGVLTKELKKYGVLSRSHPELFYRFSIEGLKDMIKDYKVPEWLDNNYYSSKYPMLYHTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1RUS9</accession>
    <accession>A0A098DCP2</accession>
    <name>I1RUS9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG07984.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T08829</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320854.1">
        <property type="nucleotide sequence ID" value="XM_011322552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RUS9"/>
    <dbReference type="STRING" id="229533.I1RUS9"/>
    <dbReference type="EnsemblFungi" id="CEF76217">
        <property type="protein sequence ID" value="CEF76217"/>
        <property type="gene ID" value="FGRRES_07984"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07984"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08829"/>
    <dbReference type="eggNOG" id="ENOG502QUAK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_411049_0_0_1"/>
    <dbReference type="InParanoid" id="I1RUS9"/>
    <dbReference type="OrthoDB" id="2582433at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <begin position="180"/>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="668" mass="75472" checksum="7A7B07219A2395B7" modified="2012-06-13" version="1">MYPTSDETPPASKVSTSNATLTSHEKLKLWRKKFADAGAMSIFCLPAIVDVTMLTFIGRGFFMTAFMDPDHLEVAGYALLVSMLLTAGVTGWVGSVGHYYMAHYAYDNMIYFHIQRLSGGFVLTLVIALCGLVSFSLQRSVSAGFVFVAYLICISTYFNILGVMSTMHLLEAPLTSRRKVILQTLPVLLLSPLISTFVNGHDLEIYLPTIYAFLLVILWHYRRLCQEWSDWMEKIPKFTSKDISEWYSMTVVNENQEAKVSGFMSSPLIRRVSEGMPFIEWLLKKTSAGKAPPPKFTTAWFTQLGEAINQQQQLRSGLKEHNSFILFRLARHDIGQNLALFLIALMDRWIMMAMSARQPYPSIYTDSRSRYGIWLSIVYFCLSAMILDATLQKYWSHRYDTSHEKMSGLEDAERTERQVESRRRELLIKAAVDVFSKLTVFFGCTTILLWLLVESTETTIIYFMYVFGYSSAIVFQFNRCFTTNISAHITVMMVSAAVSFIVGCLLHAIPATAGFLYTDVLAQNLTSLLAAAGTSCAVAFTHDQDDNESIIVQKKITADYNEDIKIAAIAARDIVVTCKMQHGDGSRGADKLGKLLQNSLRDPNCHSRATQWSDRLLRRAEDMWQTQKVTVTASTSESFYRNGLDKAFSFGYFKSGVLHVVIGLFWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RVF9</accession>
    <accession>A0A098DDL4</accession>
    <name>I1RVF9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG08233.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T09429</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320574.1">
        <property type="nucleotide sequence ID" value="XM_011322272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RVF9"/>
    <dbReference type="EnsemblFungi" id="CEF76517">
        <property type="protein sequence ID" value="CEF76517"/>
        <property type="gene ID" value="FGRRES_08233"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08233"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09429"/>
    <dbReference type="eggNOG" id="ENOG502SRQ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096874_0_0_1"/>
    <dbReference type="InParanoid" id="I1RVF9"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="251" mass="28532" checksum="2918D80E4A6AC021" modified="2012-06-13" version="1">MTKTTITIVKTLLTAMLRLREWLFIIHRNFFKLLTFTYAGAYRHHTRLPIEAIAENQDYGQNKNETIVSLVQFRRLKTEELRFVQGGATLSGAAAIGVFSWPTTEKALWATKMLWNWGLFFSLFALISSAHQRLLRHLPEKFDQEFDDQQFEVALSLFLKPVVGQQRSARECPIMLMSYSWVFFVNGYALHLLSPVFDTSGAETSEEVSILTLCGCGLVVLNFTFCGKLCRHRLAVARLKPTTTASADAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1RWD4</accession>
    <name>I1RWD4_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG08598.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T10345</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RIX1 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320152.1">
        <property type="nucleotide sequence ID" value="XM_011321850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RWD4"/>
    <dbReference type="FunCoup" id="I1RWD4">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RWD4"/>
    <dbReference type="EnsemblFungi" id="CEF76976">
        <property type="protein sequence ID" value="CEF76976"/>
        <property type="gene ID" value="FGRRES_08598"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08598"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10345"/>
    <dbReference type="eggNOG" id="KOG2149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050252_2_0_1"/>
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    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
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        <location>
            <begin position="131"/>
            <end position="229"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF76976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="342" mass="37782" checksum="B5F673CDF111DE65" modified="2012-06-13" version="1">MGSSNKKKREKQKDFQKPKFKVGKDKAKASNFTDTSFKSRAIVMGHQSLSAVAPDVVQQFRHNLSLASSSKSDKQRREALAYLTSQLSSEPPVNPVGTHAVLVKLLPLISDSSTPVRSQLLKLFRELPSDEVRHSVEQAIMFVRAGMTHLSADISNDSLGVMEWLLDVAENDLVVCPGGWVKTLSSFCAMMGWALKIPKAGWSSGTKSGLSAKGAATYARQIATLSRFLEAGLRPEAEIPEDESEIWDNLYRIPQDSNAFEYLNLYGTRRDEEGEMYPSRDARQRVFERRFLEAVLKGADQAKKEGGATGRAAAGLDQVLQNGMGEYESSTAMDTQDLLSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1RWH7</accession>
    <accession>A0A098DGG6</accession>
    <name>I1RWH7_GIBZE</name>
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        <submittedName>
            <fullName evidence="8">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG08647.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T10477</name>
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    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320095.1">
        <property type="nucleotide sequence ID" value="XM_011321793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RWH7"/>
    <dbReference type="STRING" id="229533.I1RWH7"/>
    <dbReference type="EnsemblFungi" id="CEF77041">
        <property type="protein sequence ID" value="CEF77041"/>
        <property type="gene ID" value="FGRRES_08647"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08647"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10477"/>
    <dbReference type="eggNOG" id="KOG1801">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011691_0_0_1"/>
    <dbReference type="InParanoid" id="I1RWH7"/>
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        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="6">
        <location>
            <begin position="289"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="7">
        <location>
            <begin position="553"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF77041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="791" mass="90162" checksum="839E6435A0EE0E42" modified="2012-06-13" version="1">MPAAMTPGQLVLDKSLPPLYVLSESTYVHRHEQGTLIEQKNELDILVRFNERRTTFQAWPIAPIPGLATSFHVPWLVLVVVPQMSEDLVFPSLDDNFHIDFERRIELPDGTYSLVNLPATRIGNPYEDVDYLVSKGVAKCAAFKVDVCRSWKNEEGEQVSLDLMSSMQTASSLDDFESISLDKSKHQTITITWDTFSNTFEAELSALRRLTQECQLESRQVGQKSKAAFKMILDLKGSDKTFLDLYNLFPHLKNPKASEHRIRHTILRKFRSFNSDHLAAFRGLRRIPNGLYFVNGCPGAGKTEWNMVVSALLQSKPRPGAKRRSPILFLVDLNKTVDDAADRYYGLCKEAGLKLRIVRMHGWPYEIRNSSKLNASTSENDDGHGTDFTKKFLATMSINKNVCVGRNPNKAPTLDEAAWEYYEKHQNDGFLALKRVLMRMDTGEVLNNDDWKTLRTQVTKLYTAVLRQTDFIATTPVAAYGGFSRHFKPEIIFIDEAPHARELTTLIPIAYFEPIAWILTGDVNQTRPFVKSGDIRDTYKQGIEFNPFAEQMRVSLMARAAKVGAINSSLLINKRAYGNLQKLPSVLFYHGRMISGHPAKKQFPETVSYLRTYLEKLGGGSKLKENRVVIALTKSKEETHCRSFWNPVNHQWVVGQVQALLQDSAFRCVTDIEQPGRVMIQTPYSVAMRQYTHAVKQWPDEWQNRVEVLTVDRAQGNQADVVFLDMVRTTRPGFMDEPQRMNVAITRARQAEVILMHPEMTFRLRAGLRVPTDYTSKVWNDAVQDGRMFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1RWI2</accession>
    <name>I1RWI2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG08652.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T10487</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320090.1">
        <property type="nucleotide sequence ID" value="XM_011321788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RWI2"/>
    <dbReference type="EnsemblFungi" id="CEF77046">
        <property type="protein sequence ID" value="CEF77046"/>
        <property type="gene ID" value="FGRRES_08652"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08652"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10487"/>
    <dbReference type="eggNOG" id="KOG1611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_7_1"/>
    <dbReference type="InParanoid" id="I1RWI2"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF12">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="272" mass="30001" checksum="60FF17D7F05D79E8" modified="2012-06-13" version="1">MSKPWIFVSPSTRGIGYALTRHLLQKTSLPILATARLRHDLDDVKTSLLEGLPEKDGLAKRLSIVHADVTDDKSLSDAASRAAELFPSDKHHLRLACAVPGILKPEKNPSQIDADASLEQFRVNTVGPLLLIKHFDQFLPRRSTTLEQSPEGDEVKMPPHSVWLSMAARVGSISDNRAGGWFSYRASKAGVISLGKSYDIFLRGRSGDRAISIAYHPGTVKTDLSKDFWSSTKEDKLFSPGFAVDRLVSVATGMTLDGRGKCWDWDHKEIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1RXG9</accession>
    <accession>A0A098DPY9</accession>
    <name>I1RXG9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG09038.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T28069</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328760.1">
        <property type="nucleotide sequence ID" value="XM_011330458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RXG9"/>
    <dbReference type="STRING" id="229533.I1RXG9"/>
    <dbReference type="EnsemblFungi" id="CEF83412">
        <property type="protein sequence ID" value="CEF83412"/>
        <property type="gene ID" value="FGRRES_09038"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09038"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G28069"/>
    <dbReference type="eggNOG" id="ENOG502QSAC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032323_1_0_1"/>
    <dbReference type="InParanoid" id="I1RXG9"/>
    <dbReference type="OrthoDB" id="2283785at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039634">
        <property type="entry name" value="Bul1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904:SF1">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="1">
        <location>
            <begin position="68"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF83412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="427" mass="47470" checksum="D4408597857EBB2B" modified="2012-06-13" version="1">MSLSEKPFSSHVDVQVAKLPTTPPDYEHLGIHRDGSCQPWGVAHALASSLKGKMSRKPEVQISINRHFNSKVYTTNSEISGVVSITPARNTRFDHVDISLDGMTETRRDGPDMTHMTSHRFLRLEMPIDESEYPSSNILSAGTTYTFPFIFNIPAHLTSKACTHSTVSEDVWERHMSLPPTLGGWEKDDMAPNMARVSYSVKAFVLTRTKTGFVAILGNSHRINVIPTSFEEPPLNITERDDLYKIEKSKKVRKNIFSTSQGRISAVAAQPAAVHLSKEGYEASGSSIPISFTFEPSSTDVTPPQITSAAMKVYSHTWFRDQPMRNLPTMGSQVANFGYPYSVSLPKTETKIEWTQNLDMQSTKASPVFHTATVQIPFELPTVDKMYVPTFHSCIVSRAYTVKVVLEGDVKIDLMVPVQVVMGSPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZQ5</accession>
    <name>I1RZQ5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG09907.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T06809</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPF27 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318813.1">
        <property type="nucleotide sequence ID" value="XM_011320511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZQ5"/>
    <dbReference type="STRING" id="229533.I1RZQ5"/>
    <dbReference type="EnsemblFungi" id="CEF75209">
        <property type="protein sequence ID" value="CEF75209"/>
        <property type="gene ID" value="FGRRES_09907"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09907"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06809"/>
    <dbReference type="eggNOG" id="KOG3096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082523_4_0_1"/>
    <dbReference type="InParanoid" id="I1RZQ5"/>
    <dbReference type="OrthoDB" id="205794at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008409">
        <property type="entry name" value="SPF27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296">
        <property type="entry name" value="BCAS2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SPF27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05700">
        <property type="entry name" value="BCAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF75209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="195" mass="21233" checksum="3A9C7C6C26F8AB07" modified="2012-06-13" version="1">MPVAPAYHESLPYVDQEPTPEALAAARALITAEASSQAPQPSSNTEPSFSPAITAELERVSKSTPLAPLDLSRYEAPSPSAPPATALPAAAVAHSYLSSRLTNLELLEKWGKNAWLLGNHGLEAELQALERELAVTKREVDIVNLERQKRQTAVGAEIKTLDDTWRAGVGRVLETEVAVEELRRKIREELARRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZU3</accession>
    <name>I1RZU3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG09948.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T06901</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318856.1">
        <property type="nucleotide sequence ID" value="XM_011320554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZU3"/>
    <dbReference type="EnsemblFungi" id="CEF75255">
        <property type="protein sequence ID" value="CEF75255"/>
        <property type="gene ID" value="FGRRES_09948"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09948"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06901"/>
    <dbReference type="HOGENOM" id="CLU_1959776_0_0_1"/>
    <dbReference type="InParanoid" id="I1RZU3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF75255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="128" mass="14905" checksum="871F25D7F3A07098" modified="2012-06-13" version="1">MCIEKSAAPMFLQRHLMRTIALRETSILLSTCYLASNIRFYNQSMCGHGLFSIGYNCTAHSNRYPALVHVEQRHVIQHLHTDQIANNEFFEWLMGSWLLSAILSHASLLAYRSDKIMNYDYARPFNYN</sequence>
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            <taxon>Sordariomycetes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319502.1">
        <property type="nucleotide sequence ID" value="XM_011321200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S1B0"/>
    <dbReference type="EnsemblFungi" id="CEF75946">
        <property type="protein sequence ID" value="CEF75946"/>
        <property type="gene ID" value="FGRRES_10510"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10510"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08285"/>
    <dbReference type="eggNOG" id="ENOG502S8D8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128341_0_0_1"/>
    <dbReference type="InParanoid" id="I1S1B0"/>
    <dbReference type="OrthoDB" id="4924482at2759"/>
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    <dbReference type="InterPro" id="IPR054208">
        <property type="entry name" value="DUF6914"/>
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    <dbReference type="Pfam" id="PF21858">
        <property type="entry name" value="DUF6914"/>
        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF75946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="182" mass="21041" checksum="DB91195908E2208F" modified="2012-06-13" version="1">MVQLVTVALHHRDHFSVGNARRVFDKQAYHWSIMIIPEGGQSENCHSFDATDASHINPVTFRMNNPTMDWWFRSELDIKPQRHEKLLGRIVIGEMPDEVSGEELGDFFQGIPLPMKNTNPQQSSVTWIMDAIQALQEKGWTHDFDLDRFKNFAVTYADEKMKGAEAEEPDLKFYESWKASVL</sequence>
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    <accession>I1S201</accession>
    <name>I1S201_GIBZE</name>
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        <submittedName>
            <fullName evidence="4">Chromosome 3, complete genome</fullName>
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        <name evidence="5" type="primary">FG10781.1</name>
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    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
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    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
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    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
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                <consortium name="EnsemblFungi"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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        <property type="gene ID" value="FGRRES_11421"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048766_0_0_1"/>
    <dbReference type="InParanoid" id="I1S3N1"/>
    <dbReference type="OrthoDB" id="3759773at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF88407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="510" mass="58773" checksum="AB47EC5CA31E6355" modified="2012-06-13" version="1">MSPTTNFNTIPVELLTRIFSCLRDDSKYGKEGIENSRLVSRRFRDIASKFLITEISVCLNSGSFARFESICTHPVFSKGVQRVNILLSYYEAELARDKQLYMMEARSRLLRHWETMERSRLYKRKYNVTDELFRWLGNIAWDGNSDVQQLARGEDIQTTPTPIQSLFLKAYDIYKERFEDQDSLRKDNAHIGRLVNGLASLPGLTTLNLDDTHGTKMIMRESTQTRLGDNQMHPEDFSDTGYDRTTLQHFDSAIRQSGWCGSFHTGGNRRHDGTVDLSTSPPLEMLGELCSQLGEKGVRPKSIRIAVKPPPDMRPLAMSLAQQENMKRLVSQASSLIFQFDFFSRPYSLQENPSDEMLALCSIAKPFFSAPKLEFLNIYFMEYPRSNTPPTVSLSDILPLDMSWPRLNTLWLLYQPMTMDELRDVVSKNCQAVREFTLKSPWFLQGSVHDALRTIRGFENLQTVDMTFPKGSDFRGTGALDFKWPLDEIKRYLLKETDDFPLPDELDYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I1S407</accession>
    <accession>A0A098DLG1</accession>
    <name>I1S407_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Beta-glucosidase cel3A</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Beta-D-glucoside glucohydrolase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Beta-D-glucoside glucohydrolase cel3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cellobiase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cellobiase cel3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Gentiobiase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Gentiobiase cel3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Probable beta-glucosidase G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">FG11559.1</name>
        <name evidence="24" type="ORF">FGRAMPH1_01T15951</name>
    </gene>
    <organism evidence="24 26">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="25">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="25 26" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="26">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="25">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="24 26" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="24">PH-1</strain>
        </source>
    </reference>
    <reference evidence="25" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323067.1">
        <property type="nucleotide sequence ID" value="XM_011324765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S407"/>
    <dbReference type="STRING" id="229533.I1S407"/>
    <dbReference type="EnsemblFungi" id="CEF79774">
        <property type="protein sequence ID" value="CEF79774"/>
        <property type="gene ID" value="FGRRES_11559"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11559"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15951"/>
    <dbReference type="eggNOG" id="ENOG502RSH1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_3_1"/>
    <dbReference type="InParanoid" id="I1S407"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF12">
        <property type="entry name" value="BETA-GLUCOSIDASE G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 22" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124805" description="Beta-glucosidase cel3A" evidence="22">
        <location>
            <begin position="22"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="23">
        <location>
            <begin position="711"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00070030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00083231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00083611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CEF79774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="796" mass="86722" checksum="F2BE491B97AD5DED" modified="2012-06-13" version="1">MHVPIVWMSLAGLILVSHTSATLLSQRSASLPVLVQTNRTIGTAWEEASDQARHFVAQLNTTEKIGIVTGGYRLDGPACVGTIGKVERLGFQGICFSDGPSGYARSDGSSVFSSGLTAAASWDRRLIYERAVAIGEEFRAKGSHVHLGPSCGPMGRSALGGRNWEGFGPDPYLSGVAMNASVSGIQSVGVQACSKHFIGNEQETQRTRTTEEDGTFINALSSNIDERTLHELYLWPFADAVKAGTASIMCSYNRVNQTYSCANPHLLSLLKDELAFPGYVVSDWYATHGTTSFANAGLDLEMPGPVSKDYGASYFGDQLLDAIGDDNVTESRLNDMAERVLRPYFFLGQNKDFPDLDPASTAALGVNQFGYNNPQLPVTPIPARDVRGDHAKVIRKLGAAATVLLKNVNGTLPLKKQADIGVFGNGAPYPTIGSIYFDYANTSISYEMGTLDQGGGSGIVRHTELIAPLDAIRERVRKDGGRVQILLEHKEIIEGKFRSIYPIPDVCLVFLKAFAAEGRDRDSLDLDWNATKVVESVSSLCFNTVVIINGPSVVLMPWADNENVTAILSAHYPGEEIGNSIVDVLWGDTEPAGRLPYTIPKKQRDYGAPIYNLTEPAANPDAWSVDYTEGQFIDYRHFDAMNIEPQYEFGFGLSYTTFEMSTELTVDIATGIQAQLDESKGKAPGGWVDLWEQAATVSVKVHNTGDRDGHAVPQLYVSFPQDTTPPGTPVRVLRGFEKVYLKAGETKKVTFPLQRRDLSFWDEATRQWVIPEGTFTFAGGFSSRDLRVKTETSALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I1S4J9</accession>
    <accession>A0A098D1P5</accession>
    <name>I1S4J9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T01137</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316106.1">
        <property type="nucleotide sequence ID" value="XM_011317804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S4J9"/>
    <dbReference type="EnsemblFungi" id="CEF72370">
        <property type="protein sequence ID" value="CEF72370"/>
        <property type="gene ID" value="FGRRES_11767"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11767"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01137"/>
    <dbReference type="HOGENOM" id="CLU_2277761_0_0_1"/>
    <dbReference type="InParanoid" id="I1S4J9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF72370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="102" mass="11841" checksum="1FD78164D468F82B" modified="2012-06-13" version="1">MGEIVGLLVYARLLGAKSENEHPLNYVMAQWWCQSVSDKFSTSTTWPVFIKPDIDEMGYNACKMFWYRIFRQEQKMPIPSFLDLICCTYSSDGNIWADGAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1S4S7</accession>
    <name>I1S4S7_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FGRAMPH1_01T02153</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316584.1">
        <property type="nucleotide sequence ID" value="XM_011318282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S4S7"/>
    <dbReference type="STRING" id="229533.I1S4S7"/>
    <dbReference type="EnsemblFungi" id="CEF72877">
        <property type="protein sequence ID" value="CEF72877"/>
        <property type="gene ID" value="FGRRES_11845"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11845"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02153"/>
    <dbReference type="eggNOG" id="ENOG502SCT5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135723_1_2_1"/>
    <dbReference type="InParanoid" id="I1S4S7"/>
    <dbReference type="OrthoDB" id="10265903at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_bL36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_bL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_bL36_sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052010">
        <property type="entry name" value="Ribosomal_LSU_bL36"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF72877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="99" mass="10973" checksum="97B3C70DC779F9A9" modified="2012-06-13" version="1">MASFLRTLTLSARSLTPSNALGAFATRGPWSLFTSPATTPISRALGNGLMQQTRGMKVQSSIKKRCEHCKVVRRKAGKRHNGHLYIICKANPRHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1S6N6</accession>
    <accession>A0A098DIQ4</accession>
    <name>I1S6N6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T12065</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322671.1">
        <property type="nucleotide sequence ID" value="XM_011324369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S6N6"/>
    <dbReference type="FunCoup" id="I1S6N6">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1S6N6"/>
    <dbReference type="EnsemblFungi" id="CEF77836">
        <property type="protein sequence ID" value="CEF77836"/>
        <property type="gene ID" value="FGRRES_12509"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12509"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12065"/>
    <dbReference type="eggNOG" id="ENOG502QS9U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026015_1_0_1"/>
    <dbReference type="InParanoid" id="I1S6N6"/>
    <dbReference type="OrthoDB" id="3832628at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024391">
        <property type="entry name" value="LDB19_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13002">
        <property type="entry name" value="LDB19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LDB19 N-terminal" evidence="1">
        <location>
            <begin position="84"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="389" mass="43810" checksum="22AABC4A76BE8153" modified="2012-06-13" version="1">MTGLLQLIRPREICPLLFKKRNQNKPDRPPASLDCHIGTCPVVIRHDDSNDESSTISGSLTLEVTEDKIEVQSLYALLRVHTVNRKPFKKGCKCCKHSFTELKRCNIITTATTLNKGIYTYDLSYRVPSYLPPSIDTSIVSVSYELEAIASLRRLRQSPTSLQTLALHRVLPVVRSISVMDTKTYSNRIYQMAGIEVSCAFDTVMNPRIKNRATLTMSGLRSSPGNSKDIHLWRICSGTWILEETVKSTASACLSHCRQNKGDNTRERKKRTILGYSAFYDGWTTDDDAGTLSMDFHFSIQKSLSHYTQDTGDVGDTSVSHALVMEVQMMKEIYPNGRLDLARRTGIGRILRSEHRVVLSDYTTLSTQISGESLPRYQDVCKGPPVYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I1S6W4</accession>
    <accession>A0A098DW66</accession>
    <name>I1S6W4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T16137</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323147.1">
        <property type="nucleotide sequence ID" value="XM_011324845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S6W4"/>
    <dbReference type="EnsemblFungi" id="CEF86115">
        <property type="protein sequence ID" value="CEF86115"/>
        <property type="gene ID" value="FGRRES_12587"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12587"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16137"/>
    <dbReference type="eggNOG" id="ENOG502RR5I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1781879_0_0_1"/>
    <dbReference type="InParanoid" id="I1S6W4"/>
    <dbReference type="OrthoDB" id="5402033at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF86115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="147" mass="17242" checksum="4A39BEA995A874D3" modified="2012-06-13" version="1">MKARGAIWRQIRKVNRVIDLKQQEEEGGECKVNAFIGQEAYDWVHDPFLDEKHANCQLPGLVWPRDDQDCQLIYYRGWFFAYHDADTNCTLGIAENHAISLVRFNTIPLEWDKEQDGFKQWDPMDYPICSQPIPVLNEGSDYYLGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I1S759</accession>
    <accession>A0A098DY32</accession>
    <name>I1S759_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T17061</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323577.1">
        <property type="nucleotide sequence ID" value="XM_011325275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S759"/>
    <dbReference type="EnsemblFungi" id="CEF86237">
        <property type="protein sequence ID" value="CEF86237"/>
        <property type="gene ID" value="FGRRES_12682"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12682"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17061"/>
    <dbReference type="HOGENOM" id="CLU_1266983_0_0_1"/>
    <dbReference type="InParanoid" id="I1S759"/>
    <dbReference type="OrthoDB" id="10379212at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF86237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="218" mass="23981" checksum="7B85E6F9AFA3D492" modified="2012-06-13" version="1">MGDLLIVKLQVILIPEQIKSDNRNTTFESRLTLIALIVDCSLLHSVLVADHRKRLQALSKKEGRKEGASQVETQEAGATRSRFLSPHHNSRSPFSAHSTPQQVPIPLQLPLWRHAKPGKHGVDLPKYKLTNTNLPKINVPPQYQSLAVQQASRSACLRLRGQSVVAPFLTGAVSEAVATLTKDTLAQEQFNTGMREKQLSGALEWPTSQCELSPQATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I1S962</accession>
    <accession>A0A098DCF4</accession>
    <name>I1S962_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T09663</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320465.1">
        <property type="nucleotide sequence ID" value="XM_011322163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S962"/>
    <dbReference type="EnsemblFungi" id="CEF76634">
        <property type="protein sequence ID" value="CEF76634"/>
        <property type="gene ID" value="FGRRES_13392"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13392"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09663"/>
    <dbReference type="eggNOG" id="ENOG502RMWG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3377088_0_0_1"/>
    <dbReference type="InParanoid" id="I1S962"/>
    <dbReference type="OrthoDB" id="4964810at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF76634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="34" mass="3647" checksum="E822B8BFB924EB33" modified="2012-06-13" version="1">MPAYEYCCQCGGMIVISTTCTACGHKQCNNCPLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I1S991</accession>
    <accession>A0A098DDI8</accession>
    <name>I1S991_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T09379</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320595.1">
        <property type="nucleotide sequence ID" value="XM_011322293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S991"/>
    <dbReference type="EnsemblFungi" id="CEF76492">
        <property type="protein sequence ID" value="CEF76492"/>
        <property type="gene ID" value="FGRRES_13421"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13421"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09379"/>
    <dbReference type="eggNOG" id="ENOG502RKTJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180940_0_0_1"/>
    <dbReference type="InParanoid" id="I1S991"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF76492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="79" mass="9338" checksum="72B95FA7B9441B24" modified="2012-06-13" version="1">MASFSHGWMNREQYRDEDKIATAVREGKDLWGREQDEFVRIERNEDVPPLVLEEPKRSDYMISLDGPSAGFEDYKWEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1S9F1</accession>
    <accession>A0A098DS15</accession>
    <name>I1S9F1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T28253</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328851.1">
        <property type="nucleotide sequence ID" value="XM_011330549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S9F1"/>
    <dbReference type="STRING" id="229533.I1S9F1"/>
    <dbReference type="EnsemblFungi" id="CEF84660">
        <property type="protein sequence ID" value="CEF84660"/>
        <property type="gene ID" value="FGRRES_13482"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13482"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G28253"/>
    <dbReference type="eggNOG" id="KOG3041">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_0_0_1"/>
    <dbReference type="InParanoid" id="I1S9F1"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000016">
        <property type="entry name" value="ADP-sugar pyrophosphatase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF26">
        <property type="entry name" value="ADP-RIBOSE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="104"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF84660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="257" mass="28949" checksum="4A8FF0E2EC35BD49" modified="2012-06-13" version="1">MAQDSACTVITLSPHNELPRSQHHQLLFSHVSPSDLQTSSPPPFVSRIFTMSHKTQEPVITKTSDLSLQDAKWITLKKIEYVDQVGKERTWEVATRKTRGKSGVDAVAMGNILLHPSKPASTLLVIQYRPPLDAYTIEWPAGLIDAEETAEEAAVREFKEETGYDCRVLSVSPAQAADPGMTNANMQLAMVEVQLSENEEEPEQRLDDGEHIQREIIPLAELYERLVEYSKRERTVVAAKLFHFAAGMHFAQTQKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1S9Q3</accession>
    <accession>A0A098DNQ7</accession>
    <name>I1S9Q3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FGRAMPH1_01T27071</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF82989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328285.1">
        <property type="nucleotide sequence ID" value="XM_011329983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S9Q3"/>
    <dbReference type="STRING" id="229533.I1S9Q3"/>
    <dbReference type="EnsemblFungi" id="CEF82989">
        <property type="protein sequence ID" value="CEF82989"/>
        <property type="gene ID" value="FGRRES_13584"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13584"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27071"/>
    <dbReference type="eggNOG" id="KOG0908">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_1_0_1"/>
    <dbReference type="InParanoid" id="I1S9Q3"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="171"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF82989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF82989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="211" mass="22017" checksum="30A594A4FE9E2EEF" modified="2012-06-13" version="1">MSGPISIGSESEWSSLLAGTNVVIADFYADWCGPCKMIAPTFEALAKEHSSPKKVAFAKINVDSQSGIARAQGVSAMPTFKIFQNGACIETIKGANPPALTAAIKNAVKLGGPVTGDVFKTPGRTLGGDARSAPLSKRWNLKGIFDALIAFFGLYFVSLLSFDPYKSAEKSPFNVHRKPTSGSSGSFGQGPGGARAPPRSSFKTLADLGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I1SA20</accession>
    <accession>A0A098DAH6</accession>
    <name>I1SA20_GIBZE</name>
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        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T07255</name>
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    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319023.1">
        <property type="nucleotide sequence ID" value="XM_011320721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1SA20"/>
    <dbReference type="EnsemblFungi" id="CEF75432">
        <property type="protein sequence ID" value="CEF75432"/>
        <property type="gene ID" value="FGRRES_13701"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13701"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07255"/>
    <dbReference type="HOGENOM" id="CLU_3410680_0_0_1"/>
    <dbReference type="InParanoid" id="I1SA20"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF75432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="29" mass="2970" checksum="2D9E78C13D50A521" modified="2012-06-13" version="1">MHRGPLQAGKGALGPIRGATVFAPLEEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1SA77</accession>
    <accession>A0A098DBN4</accession>
    <name>I1SA77_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T08107</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319415.1">
        <property type="nucleotide sequence ID" value="XM_011321113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1SA77"/>
    <dbReference type="STRING" id="229533.I1SA77"/>
    <dbReference type="EnsemblFungi" id="CEF75857">
        <property type="protein sequence ID" value="CEF75857"/>
        <property type="gene ID" value="FGRRES_13758"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13758"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08107"/>
    <dbReference type="eggNOG" id="KOG0192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070624_0_0_1"/>
    <dbReference type="InParanoid" id="I1SA77"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF75857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="339" mass="36480" checksum="52DF0965CB9E8B8A" modified="2012-06-13" version="1">MGAKAQESVTSSFPLGLAVLESPHLIPSLLGAGADISSMFKWDSADSEQKSATMLEVAVESAIASRCLDVVKIVLRLGAPVNRVLPDANMPSALQLAVTQEFECENLSEDLTVELVQLLLKRGADIHIPDFLGFYHIPDNFYGGFSDAVRMTLLHSAEAQGRTSLVKALVCAGADVNERAGEKGFTAFQVAARFGNAEMVSYLIQSGANTNVPQIMIFDKPALVAAVAKDDLELVSLLLQTGADPNITGMIDVGPMLKMTALQTASCQPESLWSSDDSLTIRLEMVKLLLDAGADPKTPRFTTDTEDRSPLAWAVFSYDTDVVKLLLDHSSRCFNLSRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-13" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q4I2W2</accession>
    <accession>A0A0E0RZW8</accession>
    <accession>V6RLP7</accession>
    <name>GEM1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial Rho GTPase 1</fullName>
            <ecNumber>3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>GTPase EF-hand protein of mitochondria 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">GEM1</name>
        <name type="ORF">FGRRES_08446_M</name>
        <name type="ORF">FGSG_08446</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-"/>
    <dbReference type="EMBL" id="DS231667">
        <property type="protein sequence ID" value="ESU14897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320322.1">
        <property type="nucleotide sequence ID" value="XM_011322020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4I2W2"/>
    <dbReference type="SMR" id="Q4I2W2"/>
    <dbReference type="FunCoup" id="Q4I2W2">
        <property type="interactions" value="824"/>
    </dbReference>
    <dbReference type="STRING" id="229533.Q4I2W2"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T09981">
        <property type="protein sequence ID" value="FGRAMPH1_01T09981-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G09981"/>
    </dbReference>
    <dbReference type="GeneID" id="23555450"/>
    <dbReference type="KEGG" id="fgr:FGSG_08446"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09981"/>
    <dbReference type="eggNOG" id="KOG1707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014255_3_0_1"/>
    <dbReference type="InParanoid" id="Q4I2W2"/>
    <dbReference type="OrthoDB" id="10020961at2759"/>
    <dbReference type="BRENDA" id="3.6.5.2">
        <property type="organism ID" value="2428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
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            <begin position="1"/>
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            <begin position="10"/>
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            <name>GTP</name>
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        </ligand>
    </feature>
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        <source>
            <dbReference type="UniProtKB" id="P39722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="627" mass="70226" checksum="46B92FC5ECE624FE" modified="2005-08-16" version="1">MATVRICVCGDESTGKSSLIASLVKDQFVNNKIQPVLPQITIPPSIGTPENVSTTIVDTSARPQDRTTLRKEIRKCNVILLVYADHYSYERVALFWMPYFRSLGVNVPVVLCANKSDLVGQGTTPQVVEEELLPVMAEFREVDSCIRTSARDHRNVNEVFFLCQKAVTHPIAPLFDYKEGHLKPLCINALKRIFYLCDKDQDGYLNEQEMRDFQARCFDKPLTTDDLDNIKLSIAKSLPASDLEKGIDLPGFLQLNKLYAEKGRHETIWIILRKFHYTDSLSLEDKFIRPKFEVPEYSSAELSPAGYRFFVDLFLIFDKDNDGGLNDEELEALFAPAPGLPSSWTDSSFPSSTVRNEAGHVTLQGWLAQWSMTTFIEPKTTIEYLAYLGFEPSNPKDSITAALKITKPRKRRSRLGRVERNVVLCYVLGASGAGKSALLDSFLNRPFYGLYHPTIKPRRAVNSVELPGGKQVYLILEELGELEPAILENRAKLDACDLICYAYDSSDPDSFSHIVDLRKKYPHLDELPSIYTALKADKDKTNQRCELQPDQYTSSLSMSLPLHVSVTWGSISELFVAYADAATTPSTAFPRSNEEGPDRTSLYIALGATACAGVAALTIWRRATNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>V6RDH3</accession>
    <accession>A0A098DNJ5</accession>
    <name>V6RDH3_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 11">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="4 11">4.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG06544.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T22543</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>L-homocysteine + L-serine = L,L-cystathionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4 11"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_011326155.1">
        <property type="nucleotide sequence ID" value="XM_011327853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6RDH3"/>
    <dbReference type="FunCoup" id="V6RDH3">
        <property type="interactions" value="910"/>
    </dbReference>
    <dbReference type="STRING" id="229533.V6RDH3"/>
    <dbReference type="EnsemblFungi" id="CEF83430">
        <property type="protein sequence ID" value="CEF83430"/>
        <property type="gene ID" value="FGRRES_06544"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06544"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22543"/>
    <dbReference type="eggNOG" id="KOG1252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_0_0_1"/>
    <dbReference type="InParanoid" id="V6RDH3"/>
    <dbReference type="OrthoDB" id="728at2759"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:cystathionine beta-synthase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:traversing start control point of mitotic cell cycle"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04608">
        <property type="entry name" value="CBS_pair_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046353">
        <property type="entry name" value="CBS_C"/>
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    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005857">
        <property type="entry name" value="Cysta_beta_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01137">
        <property type="entry name" value="cysta_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 10 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="368"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF83430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="517" mass="55589" checksum="3C94E6E356ED08ED" modified="2014-02-19" version="1">MASQVPHVLPRAATVHSATELIGNTPLVRLNKIPQSLGIECDVYVKPELFSAGGSVKDRIALRMIEEAEKSGRIKPGDTLIEPTSGNTGIGLALVGAIKGYKTIITLPEKMSAEKVSVLRALGATIIRTPTQAAWDAPESHIGVARRLEKELPNAHILDQYSNKDNPNAHEFGTAQEIWEQTGGKITALVAGAGTGGTITGIARGLKKHNQDIKVIAADPHGSILALPELLNQEHINEGYKVEGIGYDFIPDVLDQHIVDKWYKTDDRESFHLARRLISEEGLLVGGSSGSAMAAMLLAVKEYGFKKGDVVVVVLPDSIRSYLSKFADDDWLAANNLLPVNGVESTVNGNGDKKNSDPYEGATIAALRLKPVTSVGATSTCSEAIETMRDKGFDQLPVLSASGTKLVGLVTLGNLLSYISSGRATGQSSVSDVMFDFARLDEIVTDPREFASPINPGKRRQFVEITKDTPLTTLSKFFEWNSAAVVTEKSGDSKSLSKPIAVVTKVDLLTWMINKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>V6RI46</accession>
    <name>V6RI46_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG07794.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T25683</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327613.1">
        <property type="nucleotide sequence ID" value="XM_011329311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6RI46"/>
    <dbReference type="STRING" id="229533.V6RI46"/>
    <dbReference type="EnsemblFungi" id="CEF84182">
        <property type="protein sequence ID" value="CEF84182"/>
        <property type="gene ID" value="FGRRES_07794"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07794"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25683"/>
    <dbReference type="eggNOG" id="ENOG502QR5B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021894_0_1_1"/>
    <dbReference type="InParanoid" id="V6RI46"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF18">
        <property type="entry name" value="PECTATE LYASE 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010153390" evidence="5">
        <location>
            <begin position="18"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="6">
        <location>
            <begin position="46"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF84182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="336" mass="36784" checksum="EE94BAFBC0C6BF47" modified="2014-02-19" version="1">MKLSSALCCVFATLTVAFPSDYLKIATWGVEGYAKDNPIGVTTGGKGGKTVTVTTAEQLVEAVKGNAPKIVKLKGKIVLPARLAVGSNTSLIGVGLSAHITGKGLNIYNGDNVIVQNLKITEILDNDCITIRNSTRVWIDHNEFSSDIDGGPDKYDGQVDIIRASDFITVSWNYFHDHWKSSLVGNDATFRDLDLGHLHVTYHHNYWRHMGTRGPAGRFGHQHIYNNLYEDFLYQAIHSRSDNQVLVEGNVFRGNTSEALSTYGLVIPMDSPNTCVCGDEELDGYANLGAKNDWGHAGVNITQKGNFYKADYKFKLTPLPLVPAVVKLGAGIGRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>V6RKY7</accession>
    <name>V6RKY7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG08444.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T09977</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320324.1">
        <property type="nucleotide sequence ID" value="XM_011322022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6RKY7"/>
    <dbReference type="FunCoup" id="V6RKY7">
        <property type="interactions" value="1110"/>
    </dbReference>
    <dbReference type="STRING" id="229533.V6RKY7"/>
    <dbReference type="EnsemblFungi" id="CEF76791">
        <property type="protein sequence ID" value="CEF76791"/>
        <property type="gene ID" value="FGRRES_08444"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08444"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09977"/>
    <dbReference type="eggNOG" id="KOG0687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031814_1_0_1"/>
    <dbReference type="InParanoid" id="V6RKY7"/>
    <dbReference type="OrthoDB" id="1452at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000013">
        <property type="entry name" value="Proteasome regulatory particle subunit (RpnG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000021">
        <property type="entry name" value="Putative proteasome regulatory particle subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="229"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF76791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="487" mass="53648" checksum="0572CBA783845179" modified="2014-02-19" version="1">MGSDPQYAKWPLLPLSQHVFTLTNGYATKNAQQASVKALQDAIAQDKMAPFYRYLAHPLDGVLNTVGEGGASAPGRPLSRKSSLVGMIATKPAAANISLPWDEGLYNQLKEDNDRELEEIQKEEDDAVEQAGDTEVMAAQGKRAEFWARVGDKDKAIATYESLFEKTGILGTKIDLVLAIIRMGLFYGDKPLVKKHVERAKGLVDTGGDWDRRNRLKAYEGLHLLTVRSYNLAAPLLLDSLSTFTSYELCTYSNLVVYSVLAGSVSLKRVDFKSKVVDAPEIKAILGDGDDKLLALSGALSAGPGADDTVGAKAPKTATAAVNLTTLGTSTDHPEAEMAIDFSPLALLVSSLYKGDYKAFFTSLANVEEQFLNQDRYLHEHKNWFIREMRLRAYQQLLQSYRVVGLESMANDFGVTVDFLDRDLARFIAAGRIPCTIDRVTGKGVIETNRPDDKNKQYQDVVRQGDQLITKLQKYGQAVRLRGSERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>V6RTD7</accession>
    <accession>A0A098DBZ1</accession>
    <name>V6RTD7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG08177.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T09291</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320635.1">
        <property type="nucleotide sequence ID" value="XM_011322333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6RTD7"/>
    <dbReference type="SMR" id="V6RTD7"/>
    <dbReference type="EnsemblFungi" id="CEF76448">
        <property type="protein sequence ID" value="CEF76448"/>
        <property type="gene ID" value="FGRRES_08177"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08177"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09291"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="InParanoid" id="V6RTD7"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS sugar transporter, putative"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
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    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
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    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="Sugar/inositol_transpt"/>
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        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF48">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G06730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="404"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="33"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF76448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="561" mass="60773" checksum="945DA75DB1C60B01" modified="2014-02-19" version="1">MADETVISEPQPSPAPRKGVWHLLLENPYIFGLSLFASLGGFLFGYDQGVLTMESFATKFPRIYLDSSFKGWFVSTLLLCAWFGSLVNGPIADFLGRKGSMLVAVVIFTIGSAFQAGASDIPMLFAGRAVAGFAVGMLTMIVPMYVSEVSTAGIRGTLVVLQQLSITLGILYIGGHRCAPDIPYSGGTKDKPTFDPRHDVGSGGCTGQSDAAWRVPFAIQIFPAIVLGLGMLLFPESPRFYLMRRKEDKALNALAQLRRVHPDTNSLRHEYLAIKAEVLFDEAVNRDKFSGKKGVSLFIAQHGALVSNWASFRRLAIGCCIMFFQQFMGCNAIIYYAPTMFAQLGLSGGTSGLLATGVYGIVNTLSTLPALFLIDKIGRRPLLMCGAAGTFISLVIVGGIIGGYGASLASNKSAGWAGIAFIYIYDINFSFSFAPIGWVLPAEIFNLGIRSKAMAITTSTTWMCNFIIGLVTPDMLSTIGWGTYIFFAAFCLLAFFFTYFFVPETRGKSLEEMDALFGDTAAYEEKARLMEIASEIGLTEAFPDSTIDLARKKPATAEHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D038</accession>
    <accession>A0A0E0RKM7</accession>
    <name>A0A098D038_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T00005</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF71802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D038"/>
    <dbReference type="STRING" id="229533.A0A098D038"/>
    <dbReference type="EnsemblFungi" id="CEF71802">
        <property type="protein sequence ID" value="CEF71802"/>
        <property type="gene ID" value="FGRRES_20000"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00005"/>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
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                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
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                <person name="Tetko I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="CEF74429.1"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
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                <person name="Turgeon B.G."/>
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                <person name="Goswami R.S."/>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
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                <person name="Park J."/>
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                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
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    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A098DAD6"/>
    <dbReference type="STRING" id="229533.A0A098DAD6"/>
    <dbReference type="EnsemblFungi" id="CEF74896">
        <property type="protein sequence ID" value="CEF74896"/>
        <property type="gene ID" value="FGRRES_16017"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034443">
        <property type="entry name" value="PB1A10.08"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="536"/>
        </location>
    </feature>
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        <location>
            <begin position="565"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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            <begin position="21"/>
            <end position="53"/>
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            <begin position="96"/>
            <end position="120"/>
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            <begin position="133"/>
            <end position="144"/>
        </location>
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            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
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            <begin position="174"/>
            <end position="192"/>
        </location>
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            <begin position="196"/>
            <end position="205"/>
        </location>
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            <end position="323"/>
        </location>
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            <end position="339"/>
        </location>
    </feature>
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        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF74896.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF74896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="599" mass="66241" checksum="CB42320C122F215A" modified="2015-01-07" version="1">MMTPRSFQLAQRQQQHQHQRPLSSPCTTGTSHHNTLSIPTPSLSPVLTPISTRLSCSSSSSSSSPLPFLPSSRHHFSSSEPQSLSIPSTFHLHTSPPASTTKLATPAISTKQSTTFSLSRWSPKYDDNKKRTTTITISSAQPTFDATMGKRKDWRETSSLSPSSPPKTTVSLTMRPTTPSSPVKIPTTNNRYTAHPQKRHSSQRKRSNDSRSSGNLSPSLAALLAVTDIPKHKQLQRRRRRSEKTLTVREVIECQHASEKELSWTFSSPLDMLLSPPQDIMDDDDSVSDCNIGSSMSTRTYSIDSIPSLDGSFSSDGLSSLGSPRTPSPCSRRTKSTPMRKSLEPVISPPGSVDEHPLARDELDVDDFDLTTVDQPEEVQPKSQFLEPFKPLRSVFKSNLTASLRALRSAARSFSVLNLPSIPPDDYLTRSILTIDPNVPYADERRPPVSEEMPSAAMRRYLNPTTNARIEPPAKTVFAGTFAASIQMRTYKIQRSRAPPGSTRNSYPSTSLQSQPSPAPQQPQPQAPTLVPGMRQREMRENSDFIRIAVMEMAMRKCGKLDDQRPGRARFALPPRQTSTKPYEMGANGVPARWVPIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DBW9</accession>
    <accession>A0A0E0RYU8</accession>
    <name>A0A098DBW9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG08153.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T09241</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DBW9"/>
    <dbReference type="STRING" id="229533.A0A098DBW9"/>
    <dbReference type="EnsemblFungi" id="CEF76423">
        <property type="protein sequence ID" value="CEF76423"/>
        <property type="gene ID" value="FGRRES_17093"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09241"/>
    <dbReference type="eggNOG" id="KOG4711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DBW9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF1">
        <property type="entry name" value="DUF2421 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="569"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="688"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="6">
        <location>
            <begin position="562"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF76423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="939" mass="105375" checksum="99B7D9E07744FB07" modified="2015-01-07" version="1">MPRLIESIKDGIWDSSARCQRWLDTPNGRGVLKCTVAYTIASLATFVPFLANFLGKPEGKHVVATITVYFHPARSTGSMIEAILIAIVAVAYAEIISVLSMVTSVFFGSTMHLVTLSHVLVVVVFIGGGFGFMGWVKQRMLNPLVNVGTTLASLAIIGVVTKENHVMSNVFSNEKVLQVFKMLVMGITTTTLVNVFLWRTSARTSLRETMNRVSIPLGDMLYMITNSFVSGSEEGLVSDGFVAASTHYAKSYAQMMKDMREAKFEHYFLGHEAIYEHEKSVARSMETLSQALGGLRNATNTQLEQLRHPKLINSNTDGTSTTNTARELFEQFNESIAMSMSSVRQNLCRILHEPQFGQPPHYEINVDEDLRRNLMDSLDTFDEARSDALQGLYDRIEQMASSDFTTRANLEEVAAACGHFTFSVQSFGEDVLQYLDVLDDLQYVVLHKSRGWRWLLWWKGNEQDRNKAIRLFESAEADVLMRNRQRSVSTLSGTNNSAAVPILVDVRTWYQAPDLNKILAWVWRNISALFKKMARDDIQFGLKVGIGAALWAMLAFLEETRELYKEWRGEWGLLSFIIVCSFTVGASNTVSLARFIGTLFGALLSIINWKISHGYALVLIPLGWLTSFINFYLIIQHGKASFGRISLLAYNVSTLYAYRVKRKADGNDTADDGVFDQPDIMEIAKRRAIAVTAGIIWGLVICRVIWPISARRKFKESLSVLHLQMGLIWKRGPLTVLFRSEGSQSYLKSGEQAALQRYASDLDSLRVSAASEFELRGPFPMDVYGRVLKGTMRILDGFYNMSLVACRKGHLTEGEKALLEYTARERAILCDHICQAFQVVASSTMLEYPFADATPSIVSARENLLSKIFEFRKNHQRRLVDDDTSESSASSEVLVEERDYALLYAYALVTGQVADELRMVGKEIGSLFGVLDEDTRLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DC17</accession>
    <accession>A0A0E0RZ24</accession>
    <name>A0A098DC17_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG08217.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T09393</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DC17"/>
    <dbReference type="EnsemblFungi" id="CEF76499">
        <property type="protein sequence ID" value="CEF76499"/>
        <property type="gene ID" value="FGRRES_17081"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09393"/>
    <dbReference type="eggNOG" id="ENOG502RS6J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DC17"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="3">
        <location>
            <begin position="22"/>
            <end position="81"/>
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    <feature type="coiled-coil region" evidence="1">
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            <begin position="237"/>
            <end position="402"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF76499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="465" mass="51322" checksum="5D234121970C71C0" modified="2015-01-07" version="1">MKNSNHVEPVEPVELSPDDIVIAVMGVTGAGKSTFIHYVTGQQVGIGHGLTSHTIGVSIYAHCVTPERCVYLIDTPGFDDTSRSDTEVLEAVAFFFSQLYRKNVQLAGIIYLHRITDNRVSGSALKNVSMFKKLCGESAFGHVVLCTSMWNNLGTVLPEIGNEREQELIATSSFWGAMHAGGSQVARWQGTKESAEAVVDQIIKIHNESGKAMLKIQEELVDGGMSLDETGAGREVQREILEAKAELKERITQLQKAQEEMIQQSNETLARELASQRKVFEDRLAETTEAQETLKISLETLMEQKEAEYEKLLAGAVSEQKQLAAALQEKAAEFERVRLEQLEDEESFQEAKAEFASEVESLKQKIKDQENKMEQQKLEAELKAAEDLKAELEKRRIEEEKAAMVNTQKIDQDLKKKERRKQRMRDGMAILGTVAGVASAIAGVATMNPALIGMGASMAAGSMSS</sequence>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DC35"/>
    <dbReference type="EnsemblFungi" id="CEF76493">
        <property type="protein sequence ID" value="CEF76493"/>
        <property type="gene ID" value="FGRRES_15034"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09381"/>
    <dbReference type="InParanoid" id="A0A098DC35"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="78" mass="8245" checksum="F99B88099516D24A" modified="2015-01-07" version="1">MSVDISERDDALEVREVRPVFIAESTFTSVVAVPSVMVVAMVLSMPVAAGVEITASLDALEMDRPVNSGVSKSSYGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DCY2</accession>
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        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DCY2"/>
    <dbReference type="EnsemblFungi" id="CEF76814">
        <property type="protein sequence ID" value="CEF76814"/>
        <property type="gene ID" value="FGRRES_15487"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10023"/>
    <dbReference type="InParanoid" id="A0A098DCY2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF76814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="90" mass="9836" checksum="9D3B397F8BD9A43C" modified="2015-01-07" version="1">MGSITASLFGNFRALPSFRSICPSWDWSAKQSASHILVSHQPQASLHSTANLNPYCNTVFNKFQRSPVGSVVKRITSNDKITGSIPVRGM</sequence>
</entry>
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    <accession>A0A0E0S039</accession>
    <name>A0A098DD26_GIBZE</name>
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        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
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    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T10121</name>
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    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DD26"/>
    <dbReference type="EnsemblFungi" id="CEF76864">
        <property type="protein sequence ID" value="CEF76864"/>
        <property type="gene ID" value="FGRRES_13351"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DD26"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF76864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="73" mass="8518" checksum="63AB33CD2502CC3A" modified="2015-01-07" version="1">MDVFDVDDTQTPVPERTRFHRQETTDLIRMYPYVRLRLFIGVGIRFKSQEEESQGLKEDGLCTADEVCPYCTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DDI2</accession>
    <accession>A0A0E0S0K8</accession>
    <name>A0A098DDI2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="primary">FG08641.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T10461</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CEF77033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DDI2"/>
    <dbReference type="EnsemblFungi" id="CEF77033">
        <property type="protein sequence ID" value="CEF77033"/>
        <property type="gene ID" value="FGRRES_08641_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10461"/>
    <dbReference type="eggNOG" id="ENOG502SRJS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DDI2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF77033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="139" mass="15565" checksum="F5D03DB3E7CCFCF7" modified="2015-01-07" version="1">MSPIMARASAPNATTLSRYHATPDAARGFCTNCGSWLFWRSEKSNSMSMSVGTFDQEELKQWGQKLAYSEVHLWSEDAIEGISDHLPGEKWKYHDKGEGIERIGYITKFENQDGALGVLMVSLNIVPFEMKLYNAGLAI</sequence>
</entry>
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    <accession>A0A098DGA6</accession>
    <accession>A0A0E0S388</accession>
    <name>A0A098DGA6_GIBZE</name>
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        <submittedName>
            <fullName evidence="12">Chromosome 2, complete genome</fullName>
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        <name evidence="13" type="primary">FG03208.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T12321</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DGA6"/>
    <dbReference type="FunCoup" id="A0A098DGA6">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF77963">
        <property type="protein sequence ID" value="CEF77963"/>
        <property type="gene ID" value="FGRRES_03208_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12321"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DGA6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000266">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="341"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="353"/>
            <end position="372"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="443"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="84"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF77963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="562" mass="61636" checksum="380B833830C01D35" modified="2015-01-07" version="1">MTSGTPSLSSGTVANDTTVESQQQTRTLYQRVSVVFGQRQMDTKDLLSQKYPGSGTKESPYVITFQPNDPENAMTFPKWKKWFFTGLQAIATLATTFASSAYSGGMKQVIRYFNVSSEVATLGISLYVLGFALGPLVWAPLSEEFGRRKIFFVSFMAGTAFAAGAAGADSIAALLVLRFLTGSIGSAPLSNAPAVIADMFEKSERGMAMCMFSGAPFLGPAIGPIIGGFLAQTEGWRWLLGLMAIFTGTIWIVASLIIPETYAPYILRKRAQRLSKTTGKVYISGYDADRPARSAAHHLKATLTRPWVLLFKEPIILILSIYISIIYGTMYMCFAAFPIVFQGGRGWNQGVGGLAFLGIVVGVALAILTFVYEDKRYAKAGRTRGAPLEPEDRLPPAMVGSVLIPVGLFWFAWTSFDSIHWIVPIIGTVFFAWGLVLVFMALLNYLIDSYVVFAASVMAANSVIRSLFGAAFPLFTKQMYQNLGIHWASSVPAFLALACVPFPFLFFKYGRKIRMKCEYAAEAAAVLEKIRTQDAAITEEDAMEEAEEMWRASRHNSRASRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DGB4</accession>
    <accession>A0A0E0S1X0</accession>
    <name>A0A098DGB4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 2, complete genome</fullName>
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    <gene>
        <name evidence="9" type="ORF">FGRAMPH1_01T11385</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DGB4"/>
    <dbReference type="EnsemblFungi" id="CEF77495">
        <property type="protein sequence ID" value="CEF77495"/>
        <property type="gene ID" value="FGRRES_16393_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11385"/>
    <dbReference type="InParanoid" id="A0A098DGB4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF93">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF77495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="330" mass="37275" checksum="4D46FC554B1B071F" modified="2015-01-07" version="1">MAAGGDGHWVLASMWSLLLVSFVFVVLRMYTRVYVIKSFGADDRMYNLAFFFLLMNTVLMTIGAQYGLGQNLMDILEEEPDHLPLSLLYEAASQTFAIIAMSIAKWSLGLFLLRLVKEKWHKIAIWCMMACLISASIALGCHCWTIWNQAYSRGSRTQKPESHQQVSLHDSRLSTNMYQEDPIGLIVWTAAEITVTMICIAIPVCRPLYKKCFTKWTSRGSSNYPNSAAPYPLQTIGGGVLQAKRVDRNGSGSTADTNEQVEEHERKMGVNGPFTRTRVYPKIDERRIGGDQSKEEILGPEFRRSQIMDLEAQNGRTMSTRHTNNSERSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DGV4</accession>
    <accession>A0A0E0S2G0</accession>
    <name>A0A098DGV4_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 5">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 5">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG02980.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T11763</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 5"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DGV4"/>
    <dbReference type="STRING" id="229533.A0A098DGV4"/>
    <dbReference type="EnsemblFungi" id="CEF77685">
        <property type="protein sequence ID" value="CEF77685"/>
        <property type="gene ID" value="FGRRES_16359_A_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11763"/>
    <dbReference type="eggNOG" id="KOG0169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DGV4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="7">
        <location>
            <begin position="316"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="240"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF77685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="527" mass="58118" checksum="A18023AE09005A92" modified="2015-01-07" version="1">MILSRETKMFGDKTVSRIQPEVLSLFMRKVQGEDEHTNVCEISRGFNGSSNTLVGSTQSDEEIKSAVDVSPDALASYLVCKGNLALPTAPTYQDLDRPINEYFISTSHNTYLLGRQVATRSKLEGYIEALSKGCRSVEIDCWDGLNGQPVVKHGYSLTTSVSFRSVINAIKEYAFVSSDMPLWLSLEVHCCSSQRDIMAQVMIEVFGSSLITEPLQGCLDTLPSPSQLRGKILIKAKMPQDMNTKDSDKEGRDTVKLDQTHNDAGSMPEKGDESAAVTNQLQRKGLQEDALQKLAIYGAGKRLPHPDAIDSHRNFIYSMSETKLSKRISKEKPLGLIGTQHMVRVYPDPNRVDSSNFNPIKCWQHGVQMAALNYQTPDFNMRLNDAMFTGSLGYVIKAQPEPKQIRIAVDVLLVGGIHGLGADSPVYVELELILPDMPSQRVRTTAVSTHGAGTVFDQNLDISIGTKYPHLAFLHWSIKSLSNSRPMSTQSGIAKVSNLKKGYRILPLGVTEETGGFIFCKISVNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DGX5</accession>
    <accession>A0A0E0S3Z4</accession>
    <name>A0A098DGX5_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FGRAMPH1_01T12833</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DGX5"/>
    <dbReference type="SMR" id="A0A098DGX5"/>
    <dbReference type="STRING" id="229533.A0A098DGX5"/>
    <dbReference type="EnsemblFungi" id="CEF78219">
        <property type="protein sequence ID" value="CEF78219"/>
        <property type="gene ID" value="FGRRES_20172"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12833"/>
    <dbReference type="eggNOG" id="ENOG502QQJW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DGX5"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic-ring-hydroxylating dioxygenase alpha subunit C-terminal" evidence="8">
        <location>
            <begin position="173"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF78219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="398" mass="45853" checksum="93C0AA830DC23B22" modified="2015-01-07" version="1">MAQSFLKRCFGLGGASAAPTTCSTTPEKAAVRALPASWYTSVEMYELEKRAIFSKKWLLTTHQARLRDAGDWLKYEIANFELVIAKDEDGNINAFHNITRFGAFPIVAPEQGDHGDASTGFDQKQNGLLPIHVKVDARGFIWINMDGAKVPEVAWEDDFDNLDTHERFSYYNFEDYNFDHVWEMEGDYNWKILADNYNECYHCKVAHPDIPTIADLNSYWVETQKQYIQHFGAQRQDQIDRGFRIAVTYYLPNASTNISPHFFMIQRFVPHSPTRSTMRYEFFRNKNSSDDDFTLITELYKRVMSEDKYLCANAQKNVNAGVFINGEMHPEMEQGPLFFQQSVRSLLQEHHKKEQEAGKEIWPAQQEVPTTIISTKTNGQTNYSSGIDLRAAKKFIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2024-03-27" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DH35</accession>
    <accession>A0A0E0S2M7</accession>
    <name>A0A098DH35_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG03034.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T11899</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DH35"/>
    <dbReference type="STRING" id="229533.A0A098DH35"/>
    <dbReference type="EnsemblFungi" id="CEF77752">
        <property type="protein sequence ID" value="CEF77752"/>
        <property type="gene ID" value="FGRRES_03034_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11899"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DH35"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF213">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010018666" evidence="3">
        <location>
            <begin position="20"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF77752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="676" mass="73227" checksum="C571953475F77878" modified="2015-01-07" version="1">MRLSFFVSIVSVLSDPVLGSLIPPGFIGTEQSYDPFIGKRDVSSTEYDYVVVGSGAGGGPVAANLAIAGYKVLLIDAGGDSGEDLVEKVPALNLLSTEFEKTRWNYFVNHYPDMEQQKRDSKMTYEKSDGSFYVGRDPPKDAKPLGILYPRAGTLGGCTRHNALITIGAHDSDWSNIATITGDNSWNPKNMQSYFKKLEKNMYLPSSIVGHGFKGWLGTSLTSLTLVLEDLKFLSLVISAASATGKSLVGFLLHTVGGLGQILLRDINAPGQTSKTGLYQVPLSMTNSVRGGPRDLILDTANAVNKDGSRKYHLDIKLDTLVSKIRFDKSGSKPRAVGVDYLEGQSLYNADPRSTSTKPSDSGSVSARREVIISAGSFNTPQLLKLSGIGPKKELGSFEIPVLVDLPGVGTNLQDRYEATVIGKTAKDFKITSKCTFMETDPDPCLEDWKNGLTPIDKGVYATNGIALAAVMKSSVAQNEPDLLVSGAPAKFTGYFPGYALDSLADARHWAWIILKAHSRNNAGTVTLKSKDPRDMPVINFNYYDTGVNKNGEGEKDLQATYEGFQFARKAFDSLIPLDGDFDEVWPGNNVTKKEDAKQFLKDEAWGHHASCTCPIGSDDDPMAVLDSEFKVRGTEGLRVVDASVFPKIPGFYIALPLYMVAEKASDVIIKAAKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DHD3</accession>
    <accession>A0A0E0S1I1</accession>
    <name>A0A098DHD3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T11107</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DHD3"/>
    <dbReference type="EnsemblFungi" id="CEF77356">
        <property type="protein sequence ID" value="CEF77356"/>
        <property type="gene ID" value="FGRRES_15525"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11107"/>
    <dbReference type="InParanoid" id="A0A098DHD3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF77356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="98" mass="11376" checksum="857A33FD78CE2F6A" modified="2015-01-07" version="1">MSTTNPDIKELQSKVKEAQLAIEQMEARPPESQPSISERLLMYAQHQFLIEKVETNFQSAPGRPAKMVEQAWGIAWGIWHYHYLLSLAITINDHWNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DJ00</accession>
    <accession>A0A0E0S5Y4</accession>
    <name>A0A098DJ00_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG03995.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T14213</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DJ00"/>
    <dbReference type="STRING" id="229533.A0A098DJ00"/>
    <dbReference type="EnsemblFungi" id="CEF78909">
        <property type="protein sequence ID" value="CEF78909"/>
        <property type="gene ID" value="FGRRES_16170"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14213"/>
    <dbReference type="eggNOG" id="ENOG502SHWY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DJ00"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="254"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="342"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="3">
        <location>
            <begin position="567"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF78909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1011" mass="113934" checksum="31E31494BDD46EBE" modified="2015-01-07" version="1">MAEFAAVGVAASVLQVIDFGTRFIATAWQLSRSEHDFLMSLEDLRKTSDNFRDAQRTLESTDPGSNKAVESLVQKSVAISEEMTNSLDKIGRGRSALKKAWLTLWKEEKLKTLEVRLREVQLDLTFHMTVDLRSVARDSAEKQDQILQELRKANTNNSTEKAEAPIDSNLGYGASIVECLTDGLQLHEKIKSELIGDLVANIYNLDGEYPLLSDASDIQLSDERRTKLEQLFISRLCYETMQERELTIKDAHKGTFRWVFEDGDVTGFKNWLVSDETLYWITGKPGSGKSTLMRYLLQPVSQNQDGSNGSTTRSTSSEIAILPHGRCEEHLKQWAGNDGKLTVVSFHFWAVGSKLQSSQEGLFRTLLVQLLRAHPEVIPIVAPLRWESLCLFNLDPKGFSQIELGDMFQQAIAYISTRAKLAMFIDGLDEFEGNCHDLISLVQRCVESPIKICISSRPWVEFEGAFGDCPRLKMEDLSHQDISDYVSAKFEADAQFKSLQRRQARVATELVESIVKKSSGVFLWVTIVVASLLAGIGAGDRVEDLQKRLSLLPAEIKNLYERILENIDSGYREHTAQLLKLMAAFETQPSPLLFWYADEVDFMGRAINEDLTTVSRHEVLERIEDIRRRLNSRCKGLLEINNSVKTASYSSSHFGGTVDYLHKTVYEFVSSRRTQRRLRRYLKKPYDANLRVAAAYAALTKGAVNWTNTNSRTRDVQKSHFSLSLISCLDYASRVPPDSSKQVVRLLDHLICVSPVVPHDIWQLVNDTRPHILHKPATDSWAKHLAYVDRYTVMKNSSSEKMLRLATSMSVAEYVRARAKPGGCVATRRATTTSKRNALEGLGLLAGRMLGKWFGYNKVSLLSLVCLSDSNSKRILEHLLDKGAKPNMRFSKPSGFTLVRLTPWEEILAEAFKYCIAYEEDNKQKDNVLRCVRLMLDAGAKVNLKTVKTANKHASSNIDEEDAYRCLKRMKADPDARLEVVVNEGPITSSYYTQFTRSVASSYTVSTASSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DJT8</accession>
    <accession>A0A0E0S6U3</accession>
    <name>A0A098DJT8_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptide hydrolase</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG04246.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T14833</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DJT8"/>
    <dbReference type="EnsemblFungi" id="CEF79218">
        <property type="protein sequence ID" value="CEF79218"/>
        <property type="gene ID" value="FGRRES_04246_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14833"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DJT8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04816">
        <property type="entry name" value="PA_SaNapH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF26">
        <property type="entry name" value="PEPTIDASE M28 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010893475" description="Peptide hydrolase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="8">
        <location>
            <begin position="123"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="9">
        <location>
            <begin position="245"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF79218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="488" mass="53230" checksum="63D88D230C8DC130" modified="2015-01-07" version="1">MKLAYIFPSLALWANGACAYKRLSPQQAANDIKVQDLDNSLQKLYNIALDNNNSRAFGLPGYKASIDFIHERLSYGDQFDISVQPFTHLFSQTRKIALTGPEGEKVDAVSLQYNHATPSPGGVTAPLVLIPIDDERGSGCFEDQWKGIDMKGKIALIKRGKCHFINKLKLAKDNGASAAVVFNDNPAQTAGSGSLGAENIGKLAPVGVITYDRGNAWADRLKSGETLEINLIIDVITEKRETWQIIADTKEGDPNNIVMLGAHLDSVQEGPGINDNGSGVAALLSIAESIKQKSFKNKLRFAFWGAEESGMIGSNYYVSNLSKEEASNIRFYYNYDMIASLQPYYIVYSNSEAHKTGAQYLYEYLTEHGYPAEYAPFGSSSDYIGFLELGIPSSGIFTGAGPPQDVCYHTACDDIKNINKEAFLVNAKAAAYAAAILALSVKEVPKHEISSTNPSSKRGMARNMARWANVARGAEKVHSCGSERKVFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DL39</accession>
    <accession>A0A0E0S843</accession>
    <name>A0A098DL39_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG04625.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T15737</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DL39"/>
    <dbReference type="EnsemblFungi" id="CEF79668">
        <property type="protein sequence ID" value="CEF79668"/>
        <property type="gene ID" value="FGRRES_12213_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15737"/>
    <dbReference type="eggNOG" id="ENOG502QSYI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DL39"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="3"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF79668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="662" mass="74272" checksum="9437EDCE0D55DEF6" modified="2015-01-07" version="1">MRKRIIVCCDGTNNDLRSDGTMWSNVGRIAECISEYISKDKTTKQVVGYLSGIGTEGGSWLRMKNQATGYGLDEKILAAYGFICNYYDKGDSIVLIGFSRGAFIARCVVAFIADVGVLYKTPLRGKTVEDIYTEWTQLMTPGPENAKRRELLFVKYNSSSNARRVVDALALWDTVSSLHHSPPKTYLDPVKTQPPWNVKYAFHALALEEHRGLFKPDVWTGDYPAGVKVLKQCWFRGVHSHVGGSNEQWSNNLTNVSLSWIIAQLKENGLVSFDKDQLKRVFASDGTAKTTFQSRKDVGMKDSDNALWKFLAFGAGEKAALRTPGNGTNEFLHWSVVSQPSQLLQPVPPMKLKIPMGSLLPTEKATESEREAVRWPELYFYYTEDCQMTPEEANGRLAVNHREIFDIERPDETSRRYLPLIRGKRYCNAMSPPPPQNSGDDSEGRFHVIDDTVEMESQPQASVEPYTMTGPTNEEILRPSVNGVLRPAAYGSYGTSSTSHATASNTYEATSDRTTSVPYTSSISADMPTEQDGYRKSQDYQNGYKRGYDEGYKSGYQKGLGAPQSSTVYNDTYNKDYSISSYGNYIHEVANAETQDYPYRGSDHVSTLATDESSYDQGDGTHDVYNTANTETRSTIVQDDDSYWQENKLERHGRSRKKSSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DMN4</accession>
    <accession>A0A0E0S9K7</accession>
    <name>A0A098DMN4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T25711</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DMN4"/>
    <dbReference type="STRING" id="229533.A0A098DMN4"/>
    <dbReference type="EnsemblFungi" id="CEF83120">
        <property type="protein sequence ID" value="CEF83120"/>
        <property type="gene ID" value="FGRRES_16902"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25711"/>
    <dbReference type="eggNOG" id="ENOG502SE42">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DMN4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
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    </dbReference>
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        <property type="entry name" value="GDSL"/>
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        <property type="entry name" value="GDSL_lipolytic_enzyme"/>
    </dbReference>
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        <property type="entry name" value="SGNH_hydro_sf"/>
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        <property type="entry name" value="GDSL ESTERASE/LIPASE EXL3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010018703" evidence="2">
        <location>
            <begin position="19"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF83120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="319" mass="35556" checksum="8372E96EDE8CD472" modified="2015-01-07" version="1">MKLSGLIPLLGLLPCLEAAPSPGHPPKKAFNFSKINKIVSFGDSWTDTRFDVSGQQPSPSNPIGNTGKTSSNGKMWPMYLTTQYNASSILLYNMAVGGAVVDKDIVTTGPNDVDTQVHDKLPVYLDQQPKLFAPKETLWTVFIGINDIYRTITQDDQEETIVAIIARIRQLTLDLYSDGARQFLFVSTPPQSLFPNNRPKDIAPKLEAASQSWNKKLKKLVHDLDRELKHSTFFLFDIVPLITAVTEDPSQFPETAIYKSNAFCADYKSGTLVPDFKSETCEYNALEYMYIDGAHPTQPFHQILAKRISEQLLAGHSIS</sequence>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DS61"/>
    <dbReference type="EnsemblFungi" id="CEF84710">
        <property type="protein sequence ID" value="CEF84710"/>
        <property type="gene ID" value="FGRRES_20365"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24701"/>
    <dbReference type="InParanoid" id="A0A098DS61"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF84710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="64" mass="6843" checksum="E203D8AA40EE9350" modified="2015-01-07" version="1">MSLVVWEVYVEIKSIVWGGPAPALPQSEISILGFLSCLSGPDSRQLRNGMEPLLQGDIADLGGM</sequence>
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<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Sordariomycetes</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DUN1"/>
    <dbReference type="EnsemblFungi" id="CEF85064">
        <property type="protein sequence ID" value="CEF85064"/>
        <property type="gene ID" value="FGRRES_13563_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27321"/>
    <dbReference type="InParanoid" id="A0A098DUN1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF85064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="223" mass="23691" checksum="759910421D4A9082" modified="2015-01-07" version="1">MQIKSVPSPDARSRNGRDHRSGGNASPFLYKAQALAPCPAATGTSSSTSSGERGLAELSEVTVRSSGLALAPATVDDRSIDFPFPSLLIVALHNTNTKSPLSLQDILFFFTSHNIAHASPSRNPTGRPRLSERHESETESPRHGPCLVLYKLNHAKKHSQNTVLCTSHAAIQDTTVPPPCSAYPGTASSTVPASFYSPSDHSAGTPRLFPRKGPVSGTGTWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2024-05-29" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DXB4</accession>
    <accession>A0A0E0SJ87</accession>
    <name>A0A098DXB4_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trehalase</fullName>
            <ecNumber evidence="4">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG05622.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T18353</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="4"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DXB4"/>
    <dbReference type="SMR" id="A0A098DXB4"/>
    <dbReference type="STRING" id="229533.A0A098DXB4"/>
    <dbReference type="EnsemblFungi" id="CEF86500">
        <property type="protein sequence ID" value="CEF86500"/>
        <property type="gene ID" value="FGRRES_16511"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18353"/>
    <dbReference type="eggNOG" id="KOG0602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DXB4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010018741" description="Trehalase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF86500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="688" mass="78651" checksum="642F4561F58B39F7" modified="2015-01-07" version="1">MPSPRHIAAALVATATTASALYVNGTVVAPCDSPIYCHGDILEQVELARPFSDSKTFVDMPAIRPLSDIQEAFDKLEKPLRNNSALADFLDENFDDAGNELEEVSRDDLDTDPKFLDNINDTVIREFTEKVIDIWPDLTRRYDQDAKNCSDCPNSFIPVNRSFVVAGGRFREPYYWDSYWIILGLLRTGGSFIEIAKNTIENFLDFIEEYGFVPNGARIYYLNRSQPPLLSQMIKAYVEYTNDTDILERALPLLVQEHEFFMNNRSVPVYINNETYYLNTYNVSNTRPRPESYREDYITAENTSYYSPESGKVYKGGEELSFKQKEALYGNLASGAESGLDYTVKWIARPEDAIRDNYFPLRYLNTRNIIPVDLNSILYGNEIAIADFYEQTGNNSASEQWREVAANRSYAMHGFLWNETLWSYFDYNLTSKAQQIYFPVDENTTVVDTEDAPKGQQVFFSPTQFYPFWLGAAPDYLKNNPFAVYTAYKRVEYYLDNRDGGIPASNVETGQQWDQPNVWPPLMHILMAGLERVPPTFGIRDPSFVEVRRLALRLGQRYLDSTFCTWYATGGSTSETPKLQSTSDEEEGIMFEKYADNATNVAGGGGEYEVVEGFGWTNGVLIWAVDEFKNRLTRPKCDNLESAHSNDKRDPSAVMLNARDAKRVKKFGRRKRAAEKAAKKRSSRVFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DY52</accession>
    <accession>A0A0E0SHA0</accession>
    <name>A0A098DY52_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="13">1.1.1.12</ecNumber>
            <ecNumber evidence="10">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Xylitol dehydrogenase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">FG04922.1</name>
        <name evidence="18" type="ORF">FGRAMPH1_01T16647</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="19">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="19">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="13"/>
    <dbReference type="EC" id="1.1.1.9" evidence="10"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF85813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DY52"/>
    <dbReference type="FunCoup" id="A0A098DY52">
        <property type="interactions" value="539"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A098DY52"/>
    <dbReference type="EnsemblFungi" id="CEF85813">
        <property type="protein sequence ID" value="CEF85813"/>
        <property type="gene ID" value="FGRRES_04922_M"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DY52"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050019">
        <property type="term" value="F:L-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="17">
        <location>
            <begin position="68"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CEF85813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="408" mass="43464" checksum="B993A7A7EAE0D1BF" modified="2015-01-07" version="1">MLSQLHIVTLNTRSIREPTPAHLPTIDDSTLLYHSYNYNQFSPLHPPLQTSIAAKMSSNLSFVLNKPGDVSFEERPKPSLASPHDVLVAVNYTGICGSDVHYWVHGSIGKFVVEDPMVLGHESAGTVVEVGDKVKTLKAGDRVALEPGYPCRRCQNCLAGKYNLCPDMVFAATPPYHGTLTGFWSAPADFCFKLPDNVSLQEGALIEPLAVAVHIVKQARVKPGDSVVVMGAGPVGLLCAAVAKAYGASKIVSVDIVQSKLDFAKDFASTHVYASQRIAPEENAKNICDLAGLPDGADVVIDASGAEPSIQASIHVLKNGGSYVQGGMGKADITFPIMAFCIKEATASGSFRYGAGDYPLAVELVATGKVDVKKLITGIVDFKQAEEAFKKVKEGEAIKVLIKGPNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DYB8</accession>
    <accession>A0A0E0SK72</accession>
    <name>A0A098DYB8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T16375</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DYB8"/>
    <dbReference type="EnsemblFungi" id="CEF86835">
        <property type="protein sequence ID" value="CEF86835"/>
        <property type="gene ID" value="FGRRES_20232"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16375"/>
    <dbReference type="InParanoid" id="A0A098DYB8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF86835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="93" mass="10470" checksum="C01B427BE3CC1AEF" modified="2015-01-07" version="1">MTTTVPEPYAEHTVSEQQESSKKLSKLGRPKSQRLRLYQRLYHDGKSSPGAKKGHEKHLASMSGVGSDLVYRGDEQGKLQDAVYHKRVYLNAV</sequence>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098E021"/>
    <dbReference type="EnsemblFungi" id="CEF87461">
        <property type="protein sequence ID" value="CEF87461"/>
        <property type="gene ID" value="FGRRES_15651"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21937"/>
    <dbReference type="InParanoid" id="A0A098E021"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF87461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="66" mass="7510" checksum="9700587E812D7E38" modified="2015-01-07" version="1">MSRSSTPNTKDKPGASLPIRASFGELPMAFFLHLKICDRGKMMQLICDSMAWGRSYAWHIDDMNFV</sequence>
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<entry dataset="TrEMBL" created="2015-01-07" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098E403</accession>
    <accession>A0A0E0SQZ2</accession>
    <name>A0A098E403_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
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    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T17973</name>
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    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
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        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="CEF88855"/>
        <property type="gene ID" value="FGRRES_15299"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17973"/>
    <dbReference type="InParanoid" id="A0A098E403"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
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            <dbReference type="EMBL" id="CEF88855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88855"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="55" mass="6137" checksum="7A66EF99E351A24F" modified="2015-01-07" version="1">MSNIMDALFNGPTQASTPLKLLMLKSETGRRKKSTRQRTVPVTQINVVGRHEVLS</sequence>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RS84"/>
    <dbReference type="EnsemblFungi" id="CEF74109">
        <property type="protein sequence ID" value="CEF74109"/>
        <property type="gene ID" value="FGRRES_20061"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04605"/>
    <dbReference type="InParanoid" id="A0A0E0RS84"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF74109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="48" mass="5322" checksum="73511033EAAFD27E" modified="2016-04-13" version="1">MGKQRERQVVNDAWNLLSPSDDSDAAVPDAVCHVHTGTYRVFGLPVLR</sequence>
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            <fullName evidence="7">Chromosome 4, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
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                <person name="Sakthikumar S."/>
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                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
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    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
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    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 77 family.</text>
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    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF3">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="6">
        <location>
            <begin position="181"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF82940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF82940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="387" mass="45033" checksum="6C89655D3CD942AF" modified="2016-04-13" version="1">MVILQSSTRSLRICSFIGLSILILYIFVIFVSYSQGYRPLQLQITDTAKSNYHEEIHTDGPDQNGIINRQTDLQLLLAELWKPLIHPIDDRIFVTDKGERFEVPTSQMRWKKPLGKKVILIDTDTRLNTTEENTILDKRPLHFPTLHGRTGGHLNHYLYAMIHGYDYRLVRAADYPDRHGTWVKPAIAKEALKTHDFVISLDSDAVFTHLNLPIEWLMNLWDIRPEETLVAMAYDLDIKIDYDTRGNLVLNTGFVISQASQRTQEMYERWEDCPRSIPGCEHWNFKWAHEQSAFSHYIRYEFNRTHDVKNIPCSHANGNEFTAEGQCKCQGIFVSHNWKSKQRTPELLSRSVMTSLARRIHGQFQDNIHDLYTDSSDKTYPLEDIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SPA6</accession>
    <name>A0A0E0SPA6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG05459.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T17963</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SPA6"/>
    <dbReference type="STRING" id="229533.A0A0E0SPA6"/>
    <dbReference type="EnsemblFungi" id="CEF88269">
        <property type="protein sequence ID" value="CEF88269"/>
        <property type="gene ID" value="FGRRES_16487"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17963"/>
    <dbReference type="eggNOG" id="KOG3739">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0SPA6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000263">
        <property type="entry name" value="Stress activated MAP kinase interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031567">
        <property type="entry name" value="CRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008828">
        <property type="entry name" value="Sin1/Avo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031313">
        <property type="entry name" value="Sin1_PH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335:SF1">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16978">
        <property type="entry name" value="CRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16979">
        <property type="entry name" value="SIN1_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIM" evidence="3">
        <location>
            <begin position="332"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="SIN1-type PH" evidence="4">
        <location>
            <begin position="717"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="490"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="664"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="670"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF88269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="821" mass="90160" checksum="12D3BD3FB3660F80" modified="2016-04-13" version="1">MSVIQLEELVSYQLRTSYLDEIADGVGERLLNVNDGFINSAPFKAAGWRPNSSHHKRTHSPPIPTAIASEYFQAPKQAGLTLEDGEEDGGMLTAAGSDTMGPGMATRRRRRREQMEEEDSSDLSDESDDDTDQRAAQQIKFAKMPVRNRAGSSPLQNTNLRQVGTVSPRAPRRGSQSALGTVQERARRDTVTSSEISSENETDIPTVQRYREAARAATRAAKLQARIMEEPTPGIQRADTSLLPEEEEDSDEVSDMSDDYAESIDSASILDGVENAINASPTRQVVGTPPKNFVRQSTIRKSRPPTHPIVLGTLPPPRPMSMIRPLSVAQPRSLLSAALKAKDKKSSIPFQKFAHFSGQGTQGSIAVRIYAPFSKTPSKPFQVLIRPRVHDGQGAERVVTVADLIGLSLYRYNEEKLDPPLPKGKLNINWWTLRMVEEGGEVDDDFPPFERTKPLTSFTTVNNAAARGGGRMRSNSTAYDDFALAEASEDGYLENKSLTPQEDEEEEPVTSQDSGGGVALDSALPDEDATPRGTPGPNVNSFLSDRPRQNPIVTTTYRSNAPPADMPQAPAAVPNTSRGQQKLLRVHIMSADVAPGQMVTLDVMTDTYLAEVLDVVCRKRQLDKANHVLKLPSSGAVVMLDRPVSSIGNVTDLELYRRRFATDGPLTMAGSPSSSSPKTFPLTEQSMQKRKKSQTPMVGSHPLARESMKQDELSNASYKKYTVWRKQPMRIVGMSERILVIDGEYIHIMPASGGKALQDGSGKTTTVHFSNVVGCKVFRKHPTNVKLIVYKATESKRYDFEARSALEAAEIVEELKKGMFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YID3</accession>
    <name>A0A1C3YID3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FGRAMPH1_01T04717</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YID3"/>
    <dbReference type="FunCoup" id="A0A1C3YID3">
        <property type="interactions" value="901"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YID3"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04717"/>
    <dbReference type="eggNOG" id="KOG1961">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YID3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="8">
        <location>
            <begin position="156"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="9">
        <location>
            <begin position="341"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SCB64333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="662" mass="74286" checksum="2CC1D1A652471933" modified="2016-11-02" version="1">MWLDRLAGGPATSPGPSTPQPGGRPYPKRTSSTLSPYITSQRPGVSPRGSSLSLASNESSSSLLSSARRPNGSGLRQASTIETGPDSLEVLETLLAGFSNNNAQTEKNPIINKDDLSLEANFGGLSLKELAASQPPDTTTPYKRKPKTTEESEKDRANLEDLHRSIEACDDVLESVELNLANFRNDLAMVSADIESLQTRSAALNKRLENRKQVEKALGPLVEELSLPPEVISKISEGHIDESWAKMLAELDRRSNMFKKKSETEMSNAAKDLEPILEKLTLKAIERIRDFIVAQIKALRSPHINAQIIQQQNFLRFKELFIFLHKHHATLANEIALAYMNTMRWYYLNQFSRYERALARIKLHILDKNDALGHEDTTRKATVLSSNRAPGPPHDAFNLGRRIDLLKTNNQAALSSYLAEEDQTTHYLEVPFRNFNLALIDNATAEYTFMATFFSPALSFKQISKNFNYIFEPTFELGRTLSKTLVGDTYDALGLLLCIRLNQHFAFELQRRKVPAVDGYINATTMLLWPRLQVIMDRHCESVRQLINAIPSKPSRAEAAKLSAAPHVVTQRFGQLLHGFLALSTDAGDDEPVVSSVRRLRSDVETFLTRHAELFGDKRKSGRFLYNNYSLILTIISDANGKLADEQQEHFEELKIQHQESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YIL9</accession>
    <name>A0A1C3YIL9_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FGRAMPH1_01T03053</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YIL9"/>
    <dbReference type="FunCoup" id="A0A1C3YIL9">
        <property type="interactions" value="406"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YIL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03053"/>
    <dbReference type="eggNOG" id="KOG2516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YIL9"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052917">
        <property type="term" value="F:dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SCB64206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="552" mass="59991" checksum="02A65B586AC7E7F3" modified="2016-11-02" version="1">MKTSDIILTCIFITIPLTHLLVSPYTKVEESFNIQAVHDILVYGTPTKDVNDRLSHAYDHFTFPGAVPRTFLGAMLLAGIGQPIIALVGFEHAQLVVRGLLAAANIAALLTFKNILKRAYGQGVSAWWVVFMASQFHINYYISRTLPNMYAFGLTTLASAFLLPQASTGLSLVRHKQAIALLVIAAAVFRSEVAILLGTTGLYLLATGRITLGTLIIVFFSSFLASIFVSVPIDSYFWQEPLWPELWGFYFNAILGSSSEWGISPWHYYFTSALPKLMLNPLVPALVVFALLQPGTSRAAQALTIPNLLFVAIYSAQPHKEARFIFYVVPSLTAAAALGANYISSRASKTIVYRAASVITAIFTLASFGASTVMLLISSLNYPGGDALQQLYYITRDDPTPVMNVHADVLTCMTGLTLFGQNPSGYLLASPITPEPDATAPVLLFDKTEQEDKLSLPGFWERFDYALAEDASKVLGGWQVVGVVTGYDGIEFLKAGSSPAGDESEEGRIGGEKVLGLGAHVAAARNFVRGYTGGWWVGPRISPKIRILRRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YIQ3</accession>
    <name>A0A1C3YIQ3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T03789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YIQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03789"/>
    <dbReference type="eggNOG" id="ENOG502SQ7Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YIQ3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018744">
        <property type="entry name" value="DUF2293"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38113">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38113:SF1">
        <property type="entry name" value="DUF2293 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10056">
        <property type="entry name" value="DUF2293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2293" evidence="2">
        <location>
            <begin position="176"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB64265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="804" mass="90573" checksum="9D028327868EC4E4" modified="2016-11-02" version="1">MGREKRNLPAAVAGGPKERHRRAQRSQFDHAAPVPPGFVAKPALPKTTKHHSYFEFVENKDKKKKKLEFQITTKKTPPPGFEFVPAGNPELTSACKELSREKDAMIFIVSNAKDNSASNVLSHQVHRIGHHVRETIVDEARASLGQSIEDMLPAARGAPEPIPASQAEYDAQVDAALRDLFPRIPNTDRQMIIEHAFRRDPTNKNEKEKVGFSDDITLARRVQLAVLAHIRHTHTRYDTLLRETSWQNARKVVENLCLDTLVKWRGDEESGRDQLDEILREVVVISDSEGEESGNESDSSIEEVFYQPINLVPNIPVQHISGQAGHVHRQSPRLNLGAKGPVTPKPKSKVKKAKRKTSAEKKGQRGFKRYQAWQDAIDRNRNVPDSAPESPQVPIPQRTQGLPPPALVPMDDSLPPASQLRLVSGAGPAPYENGYVGKPQYPSNGHFMSSGPQVARKVKSPFYEPPSITRPLVSTAADRLQDMLVQSIEPVSPNTMKPSFVRAVPPRGQGFRNEPPQSSSIQRPAILTSPSRRMEMRDEPMQVPRPGPSERLAYGERPFEFPVRAPSPQPGVGIPSASLHHYDTRSRGAQNPARILVSRRPYDEVQRFGDRDTPIVMEDRGGFYERVPVRSTGDIVMPARDERVPEYRRGIPEVPMVPDDRRVMWQDEPRLLRAGRNNADVGIIPIGHAPLENQQRPVVTEHRAIPYPVSATRAQSDIRSYFEPGPRLVRYDPPGPEPRVIISDPMAPRYETIREIRHEGQVPESFQQWEPVHRYYRDGPPITEDRRRPPPLQPRRPEDVVVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJB9</accession>
    <name>A0A1C3YJB9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T07029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
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            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
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                <person name="Shim W.B."/>
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        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
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                <person name="Trail F."/>
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                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
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                <person name="Goswami R.S."/>
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                <person name="Harris L.J."/>
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                <person name="Kennell J.C."/>
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            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Freitag M."/>
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                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
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                <person name="Bluhm B.H."/>
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                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
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                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
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                <person name="Wapinski I."/>
                <person name="Yoder O."/>
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                <person name="Zeng Q."/>
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                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
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    </evidence>
    <sequence length="368" mass="39644" checksum="A954DA20B1B45EEF" modified="2016-11-02" version="1">MAHLLRRSILRPLVASKPFVTPIATHRITRLASHLSTAKMAPVPSTMKAVQINKNGGVEVLEHNDVPVPKVGEGQILVRNQIAGLNFIDTYFRSGLYKAPQFPLTLGREAAGTIVDIHSSVKGFENGSRVVFMGTVGAYAQYSVVNASDAVKIPDDVPTEQAVAAYLQGLTAWTFIREAGQVKEGQWVLVHAASGGVGTLLVQLLRTVGAKIIGTASTDEKLELAKKNGAEWVISSHDDVVAKVKEITGGHGADVIFDGVGKVTFDADLELIAPKGTLISFGNASGAVDPVSLFRLTPKNVRLMRPVVNGYVAQRADLEKYTSELFDLIKSKKLELTIHKVYPLADVAKAHEDIESRKTIGKLLIKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YK52</accession>
    <name>A0A1C3YK52_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T20079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YK52"/>
    <dbReference type="STRING" id="229533.A0A1C3YK52"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20079"/>
    <dbReference type="eggNOG" id="ENOG502SDT6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YK52"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="479" mass="53636" checksum="CEE5DDF939ABA48E" modified="2016-11-02" version="1">MFDQASGQVFTEYAMSRGALAESDEDSAGWSRCRPYPSFTARGPHGPRPLVDMAISILADNIGKVRSGAHLETIPSNMLWRIWRYLEARGVCLHAWKIFSKILMDDQDDKTLGLYRFRQHICRPGTDLTRYTQPLTAPPTDFITHLVLTGGCSFSTHDLLCLADMPNLGALELIKPADELQTIFPRVSDRLVRGWTEKKDPFPLLRILRIWGDQSTTHESLKWVSKFPSLALYDVMGAREDWTQSYEAALENGWEQDDAPSGLEDSLLRYLMLFAPLEETRSKPLRDLAASIDNDLVSLCSDSRCAVKFVQEHQAPPLLDYLTDTAKVQTPSWDTDAASREARACHGVAFEPWAFWLYSFLGQLSSDQDLEARGARPTTKAVAGPFVLPSRPLACLHLGHSSRSGGIGTRPSYVSRGLFATRRYTFARDAAGRDTARAKPVPIPKKETSLVASQRSAPVLALRKQKRKRLDDVLQDLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKR0</accession>
    <name>A0A1C3YKR0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FGRAMPH1_01T23361</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKR0"/>
    <dbReference type="FunCoup" id="A0A1C3YKR0">
        <property type="interactions" value="854"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YKR0"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23361"/>
    <dbReference type="eggNOG" id="KOG2334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YKR0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102264">
        <property type="term" value="F:tRNA-dihydrouridine20 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="11">
        <location>
            <begin position="103"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="380"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SCB65130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="425" mass="46399" checksum="F5CC353D0C20032A" modified="2016-11-02" version="1">MLTKIIRRTMATEVKRVPIPRRGVDYRGKVVLAPMVRSGELPSRLLALKYGADLVWGPETVDYSMIGTSRRFDEESKTLEWFRTSSHGQKDPPPDAKESIIYRLHPELEKDKLIFQIGTADPDRAVEAARLVAADVAGIDVNAGCPKPFSTSGGMGAALLQTPDKLCAILEALVKNITPEFEIGISVKIRLLDTAAETEALVRRLCATGITGLTIHCRTTPMRPRERAIRGQLRMIAEVCHEFGVACLVNGDVEGRDHGLQLAEEFGADGAMIAVAAEKNPSCFRSKANGGVAPWEEVVKQYVKTSIEVDNRFGNTKFLLSNMIPGKSKFYQPVNQSKTYKSICEALCLDDYLEAAIAVDKRRGLGQPLQGKAAKKAAAKALAAANAQSPKSEQGKEQKRKRKMSDSRPTKQVKASEPTPVAATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YL11</accession>
    <name>A0A1C3YL11_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor RSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pre-mRNA-splicing factor rse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FGRAMPH1_01T24337</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YL11"/>
    <dbReference type="FunCoup" id="A0A1C3YL11">
        <property type="interactions" value="1323"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YL11"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24337"/>
    <dbReference type="eggNOG" id="KOG1898">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YL11"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001143">
        <property type="entry name" value="Pre-mRNA-splicing factor rse-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000068">
        <property type="entry name" value="Pre-mRNA-splicing factor rse1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="12">
        <location>
            <begin position="20"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="13">
        <location>
            <begin position="464"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="11">
        <location>
            <begin position="856"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SCB65220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1212" mass="133722" checksum="C6E1349E884DC37F" modified="2016-11-02" version="1">MATTSNMFLYSLTVQPPTNVTQAVLGQFAGTREQLIITGAGSQLSLLRPDPSQGKVITLLSHDVFGIIRSLAAFRLAGSNKDYLIIASDSGRITIIEYLPAQNRFQRLHLETFGKSGVRRVIPGEYLACDPKGRACLIASTEKNKLVYVLNRNSQAELTISSPLEAHKPGVLVISMVALDVGYSNPVFAALEIDYSEVDQDSTGQAMEELDTQLVYYELDLGLNHVVRKWSDPVDPTASILFQVPGGNDGPSGVLVCGEENITYRHSNQEAFRVAIPRRRGATEDPNRKRTIVSGIMHKLKGNTGAFFFLLQTDDGDLFKLSIDMIEDEEGNPTGEVKRLKVKYFDTVPVASSLCILKSGFLYVATQFGNYSFYQFEKLGDDDEELEFYSDDFPADPKASYEPVYFHPRPTENLALVESIPAMNPLLDCKVANLTGEDAPQIYTICGNGPRSSFRMLKHGLEVNEIVASELPGIPSAVWTLKLNRSEQYDAYIVLSFTNGTLVLSIGETVEEVSDSGFLTSVPTLAAQLLGDDGLIQVHPKGIRHIRNGNVNEWAAPQHRSIVAATANAHQVAVALSSGEIVYFEMDADGSLAEYDEKKEMFGTVTCLSLGDVPEGRLRSSFLAVGCDDCTVRILSLDPESTLENKSVQALTAAPTSLAIIAMEDSSSGGSTLYLHIGLHSGVYLRTVLDEITGELTDTRQKFLGPKEVRLFQVTVQGKTCVLGLSSRPWLGYADPITKGFVVTPLNYVDLEWGWNFSSEQCEEGIVGIQGQSLRIFNIDRLGETLIQKSIPLTYTPKKLVKHPDQPLFYTIEADNNTLPPELRAQLLADPGVVNGDSRVLPPEDFGYPKGTRRWASCINVIDPLSEEGQVLQTIDLENNEAAVSAAIVPFSSQDNESFLVIGTGKDMVVNPRSFSEGYLHIYRFLEGGRELEFIHKTKVEEPPLALLAFQGRVLVAVGTSLRIYDLGMRQMLRKSQAEVATQQIVSLNTQGSRIIVGDVQQGVTYVVYKPASNKLIPFVDDTIARWTTCTTMVDYESVAGGDKFGNMFIVRCPEKASEEADEEQSGLHLINARDYLHGTPHRVSLMCHFYTQDIPTSITKASLVVGGQEVLLWSGIMGTIGVFIPFVSREDADFFQNLEQHLRTEDPPLAGRDHLMYRGYYAPVKGVIDGDLCERYNLLPNDKKQMIAGELDRSVREIERKISDIRTRSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLA8</accession>
    <name>A0A1C3YLA8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T24483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YLA8"/>
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    <dbReference type="STRING" id="229533.A0A1C3YLA8"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24483"/>
    <dbReference type="eggNOG" id="ENOG502QVP1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YLA8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="FSAF1-like"/>
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        <property type="entry name" value="Ribosomal_biogenesis_FAF1-like"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096:SF1">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FSAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="304"/>
        </location>
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        </location>
    </feature>
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        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
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        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
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        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB65233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="304" mass="33445" checksum="FB9E4DBBDA13761C" modified="2016-11-02" version="1">MAILGKRKADSKPAISEEDAAAIFRRHFEAQFAPLPDAKEPKSSSKKTKHDDESDEDDDVEGSDSDSNDGSDNEDEGEWGGLSGGDSSEEEEEEQPRVIEVVDHSGKQPTATATMSKRELKAFMSSRPPDQTFTKSEPTPAATPSSPNDLPEDAPSLLAQDLELRRLIAESHLLAPTISASGTTVTPKTFAAGRTRQKATDMRVQALGSKVSIHKQEKMPMNMRKGIVAAAEARETKRRREAKENGIILERETGKKKGRQDRRRDMAVDRPGIGRLRGAELRLSDKDIKGIEGTRDTFGRRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLR3</accession>
    <name>A0A1C3YLR3_GIBZE</name>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FGRAMPH1_01T26203</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Sulphite efflux pump required for the secretion of sulphite as a reducing agent. In the presence of sulphite, cystine in keratin is directly cleaved to cysteine and S-sulphocysteine, and thereby, reduced proteins become accessible to hydrolysis by a variety of secreted endo- and exoproteases. Excretion of sulphite mediated by an efflux pump also represents a detoxification pathway for dermatophytes during infection of the epidermal stratum corneum, hair and nails, which are rich in cysteine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YLR3"/>
    <dbReference type="FunCoup" id="A0A1C3YLR3">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26203"/>
    <dbReference type="eggNOG" id="ENOG502QT02">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YLR3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09318">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Malic acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
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    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF1">
        <property type="entry name" value="SULFITE EFFLUX PUMP SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
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        </location>
    </feature>
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            <end position="320"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SCB65364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="413" mass="45192" checksum="613FE11B11CD03A6" modified="2016-11-02" version="1">MSGCNSTTSTGTVQAACNGSTPNPCESNLPCKEETGWRRVIRNFTPSWFAVNMGTGIVSILLHNLPYNAIWVQYISYIFFGLNVVLFTVFTALSIARYTLYPTIWSAMISHPGQSLFLGCFPMGLATIINMMVFSCKHWGDWVIYLAWSLWWFDVWVSVATCVSMPFIVMHRHRPGLENITAALLLPIVPAVVAAATGGIVAEELPNHHQALTTVIASYVLWGIGESFSAIVLALYFHRLTIHSIPPKEVIVSVFLPIGPLGQGGFGIQQLGKVAMHVVPKTNAFGEVAVRAGEMLYVLGVFFGIVMWGFALVWLSFALISIAMMPNVPRNLGAWGYTFPLGVLATCSNALAENLDSDFFKIATMIISLAVVVLWVVVAARTLKLAITGEMFHAPCLKDLREKSQAAGSDRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLU6</accession>
    <name>A0A1C3YLU6_GIBZE</name>
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        <submittedName>
            <fullName evidence="12">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FGRAMPH1_01T26977</name>
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    <organism evidence="12 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="SCB65429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="229533.A0A1C3YLU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26977"/>
    <dbReference type="eggNOG" id="KOG2118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YLU6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
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    </dbReference>
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        <property type="entry name" value="DUF21 and CBS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACDP"/>
    </dbReference>
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        <property type="entry name" value="CBS_dom"/>
    </dbReference>
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        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="CNNM"/>
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        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="47"/>
            <end position="213"/>
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    </feature>
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        <location>
            <begin position="232"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="491"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SCB65429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="561" mass="60612" checksum="28087613292E2EB0" modified="2016-11-02" version="1">MAHATRYNMGSIRPAVIGMGRVFGASLTAVSAFPIDTEGHHGEEEGEGASLWVLAVASMVLVLLGGAFAGLTIAQSKNAKRVLKLLNRGKHWVLVTLLLANVIVNESLPVVLDRTLGGGVAAVVGSTVLIVIFGEIVPQSICVRYGLPIGGYMSTPVLLLMYITAPISWPIAKLLDWILGEDHGTLYKKSGLKTLVTLHKSLGEISERLNQDEVTIITAVLDLKDKPVAEVMTPISDVYTLAEDHILDEETMDDILSSGYSRIPIYRSGNHLDFVGMLLVKTLITYDPEDRIPVREVPLGAIVETRPETSCLDIINFFQEGKSHMVLVSEFPGSDHGALGVVTLEDVIEELIGEEIVDESDVYVDVHKAIRRLTPAPRARRIHAAATAASVIASKKAPGDSILVDIEDHDAPSHHEPETASFHSNYEGGFHNAARTAIHMKRRTSDGGIEGTPVVVKASLDEMRSKLRLGPANRAANPRSNTRSLFKIKQGLSANGTPPSDNSRPLPPRAQSHMGFVNPQGSPARSHGHERTPLLGVGEDNEHAVEDDETHENTGHKTNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMS4</accession>
    <name>A0A1C3YMS4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T12803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YMS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12803"/>
    <dbReference type="eggNOG" id="ENOG502R5A8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YMS4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48174">
        <property type="entry name" value="DUF946 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48174:SF5">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008687667" evidence="2">
        <location>
            <begin position="32"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB65806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="457" mass="51408" checksum="155A357C86C53FAA" modified="2016-11-02" version="1">MFGGALSQMAIRKQLLLLSLASIFIPAVSEASGLNRCPDYVASHAPLVWLHPEDRFMPSDLAAHISNTIPKLDRQPISGLSSFDLENLGDLNGYGGEEVALTSKEDPLTYPTWILGEAPDAKGQIHNSVPCAVILVEKSDIDVDAFYFYFYSFNEGPNITQVLEPINRFIAGDHLSSGIHFGNHVGDWEHNMVRFHNGTPVGVYYSQHVDGVGFKWDSSKINITDGRPVVYSAAGSHANYPSRGHQIHNAALFDYCDEGKIWDPVLSAYFYRFNPDTSTITPIISPLKPSATKPAQNLTSWFDFVGHWGDIRYPDSDPRQKTVPHFGLKRFNSGPNGPRFKHLVRKGLVRDHPRMTGWKEWAVSIFMAWYPCCIRGWRLWRSLGIIAVALSLFVLALIFGIRKYKTLRQRMAYTKLGGDDIAMNELGRQEECLVSSDSDSDDEDDYRRDRCEAMMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1R9G1</accession>
    <accession>A0A098D0K9</accession>
    <name>I1R9G1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG00100.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T00291</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF71945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315700.1">
        <property type="nucleotide sequence ID" value="XM_011317398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1R9G1"/>
    <dbReference type="STRING" id="229533.I1R9G1"/>
    <dbReference type="EnsemblFungi" id="CEF71945">
        <property type="protein sequence ID" value="CEF71945"/>
        <property type="gene ID" value="FGRRES_00100"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00100"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00291"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_1_2_1"/>
    <dbReference type="InParanoid" id="I1R9G1"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF53">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124007" evidence="5">
        <location>
            <begin position="23"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="61"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF71945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF71945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="503" mass="55216" checksum="7A2854CE7572127D" modified="2012-06-13" version="1">MFSNTAIGLLSLTALWLNPASATEKSDTGCEVLKLTFPDNTFSPKDAVYEYESQNFWSNNEILSPACVFRPTCPTQVAEAVKLMSLGLTSFAVRGGGHMAITGANNIDDGPLFVMSNLTTLELTQDKKSVWVGPGLDWGHVYRYLGQHKLAVAGGRLSPVGVPGLLLAGGVNFHCNQRGWAADNVSEYELVLVEGKVVSVTAESYPDLFWALKGGSNNFGIVTKFRLATLPSDQIYAGVYSVADIPGFLKAVANFSAFNTDPLAHIVPQVIAVDEETTIGGAILFYDSDSDPEPECFRPFFDLPSIGNTFQKQTLAQFSDETGKLVTPKINDQFIAGTTTGKTYEEILEGVQIVNDVFLAALPELYKVLPVEDRKLISVDWQPIGSLWEKASKKYNPGGNALGLDTETKGTYIAWAEVVEWSGDEHNDEIFKWIEDTTWAIGNATQKAGLYDPFYYMGDAAGFQNIYDGYGAENKQRLLDISRKYDPLRVFQKYWPGGFKIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1R9P8</accession>
    <accession>A0A098D295</accession>
    <name>I1R9P8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG00201.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T00541</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315819.1">
        <property type="nucleotide sequence ID" value="XM_011317517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1R9P8"/>
    <dbReference type="EnsemblFungi" id="CEF72071">
        <property type="protein sequence ID" value="CEF72071"/>
        <property type="gene ID" value="FGRRES_00201"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00201"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00541"/>
    <dbReference type="eggNOG" id="ENOG502SHUR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019101_0_1_1"/>
    <dbReference type="InParanoid" id="I1R9P8"/>
    <dbReference type="OrthoDB" id="2988756at2759"/>
    <dbReference type="PHI-base" id="PHI:5797"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF2">
        <property type="entry name" value="SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="21"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="364"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF72071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="398" mass="43949" checksum="B035DF07DB796319" modified="2012-06-13" version="1">MDAIQEQFTLLSLGLFTIGVRMVVRTRSVGFSGWQLDDYLMPITGIIFTAETVAAYLVGAKFQGLTNSYMTDEERANIDIDGEEHYNRVWGSKIQVIGWSFYACILWCLKFCVTAFYARLTSGLSHLRIRVIIAYVILGITYAVVFFTILLSCQPFHHFWQVNPDPGLICQPTKSPAYVLVVVIPNILTDIYLLSIPLPLLWGVNISLRRRLTLMLLFSGALFIMMAGTIRAVTILTAGVEGAISGSSWACRETFVAIIVTNLPIIQPLIRKGASLIGLSVLFSRATKSASQSHQLRSNEGGSRFNNSRARRTNNTNKSESGHPLSTMPQTTAWASDEHILPGTSGGNNSKGIVVAQEISVQSEAFDDSNMRDVTNKDPAVHDWGYDSGNDKSRTRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1R9V4</accession>
    <accession>A0A098D152</accession>
    <name>I1R9V4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG00266.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T00711</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_011317605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1R9V4"/>
    <dbReference type="STRING" id="229533.I1R9V4"/>
    <dbReference type="EnsemblFungi" id="CEF72157">
        <property type="protein sequence ID" value="CEF72157"/>
        <property type="gene ID" value="FGRRES_00266"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00266"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00711"/>
    <dbReference type="eggNOG" id="ENOG502RS63">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022135_0_0_1"/>
    <dbReference type="InParanoid" id="I1R9V4"/>
    <dbReference type="OrthoDB" id="3506470at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF72157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="659" mass="72780" checksum="B467EFB58400AF2B" modified="2012-06-13" version="1">MTSLLPLSSPTPRPDTPPMLFDHQVLEDMMDCFPEMLARDLERSKPLFESKNMTAGMPSGPVWFAENHISNQNSSPSRTIASPYQSGSILVQNLGSIQERRSMVSFLEHRGQEMEEVESDEESVSPSESSAGIPVPSIKLREQSIATAATSLTSASGNPPSPKSLSPTERGHEYSWIDADSEADEEDVRSVNRDQLTTPRGMAALSPRPPTPTNIESTFDITVMMKAPQPRLHRACSYADESPKSSKQHRRQISSKSLDAPVIPPRVASLASTTESANTTPRLRTPVYDSRISPDRHGYTKKSFTSYRFRDETDNSTILLKSDFGSIELEIEDEDRYMDHYPPPPPLSRPETVYIEQTPPPSPLPTVESWLNDSNPPCMPQIPVDDLVKAVPLPPDVIETLRVSIACFPETMLLSSSLTTETIRSYSKKVRSPSVDSWAEPARDSSSLHPRKSIWKKVVSHGRDSSATRRHRLHSYDSNTSSGSVAPPVPWASLRHVFPGCSDYICDALYAHIVAYNYVSRVPRNHPAGNRASTPDPKSQGENIPKKAASILGLSAMQTNPTPNVGRFARKFSSPLTAIGLGKEETSTVTNHDNATRNIESGLLRCISRLVGTAKMITENGTAEERIMDTEPQAVDMMFVRSLCEIVRLCEEVSSPQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I1RA10</accession>
    <accession>A0A098D012</accession>
    <name>I1RA10_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">FG00327.1</name>
        <name evidence="14" type="ORF">FGRAMPH1_01T00861</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315976.1">
        <property type="nucleotide sequence ID" value="XM_011317674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RA10"/>
    <dbReference type="FunCoup" id="I1RA10">
        <property type="interactions" value="1049"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RA10"/>
    <dbReference type="EnsemblFungi" id="CEF72233">
        <property type="protein sequence ID" value="CEF72233"/>
        <property type="gene ID" value="FGRRES_00327"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00327"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00861"/>
    <dbReference type="eggNOG" id="KOG1968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003574_1_1_1"/>
    <dbReference type="InParanoid" id="I1RA10"/>
    <dbReference type="OrthoDB" id="446168at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17752">
        <property type="entry name" value="BRCT_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000021">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000001">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="RFC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25361">
        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="13">
        <location>
            <begin position="317"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="957"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="407"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="970"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1001"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1039"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CEF72233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1049" mass="114563" checksum="4EDECCEDCF28CCCA" modified="2012-06-13" version="1">MPSDIRAFFGPKGGSAPKPAPRKAEELAKTKRATKGRKVVEDSEDEDDEAVEVKKTAVKPAPKRKIKDEEPRGVSISADDYFASSKANKSTTSAIPKKPAAKPEAPVRSSPRKRAPASKPPAPAKNGKATATRKATTSHSHNAADQDSDAYMDDGDEDDGDIFAADAKGRSKRKNDDYEEDESDEEVLPQPKRLATRGRRAAVKKEDSDDDVKPAPASKKRKSPAEDSEESEDEAPRKKTATAKPKAPAKPRAPRAKKADEPEDDEIKNILESVATVRAPTPPPKDSDNKFDWRKKAFGGGNASAQPASGSVELPEGEEECLSGLSFVFTGVLQTISRDDGQALVKRYGGKVVGQPSSKTSFVVLGDDAGPSKLAKIQSLSIKTIDENGLFDLIRKLPAFGGGGKGAQKAQEKKKADEDKVRKQAAEMEAEEKARKVEAEKAAKKAAAGGAPVKAVAAPPVQLLTSKYAPTQLSHICGNKAQVEKIQSWLRNWPKNKKYNFQRRGADGMGGERAIIVSGPPGIGKTTAAHLAATLEGYDVLESNASDSRSKKLVENGVSDVMNNTSLLGYFAGDGKNVDATKKKIVLIMDEVDGMSAGDRGGVGALAKFCKKTEIPLILICNERKLPKMKPFDHAAFDIRFNRPTVDQVRSRIMTICHREGLKLPPTVVDALIEGSNKDIRQIINMISTAKLDQTSMDFDQSKAMSKAWEKHVILKPWDICQKMLAGGLFAPASKATLNDKIELYFNDHEFSYLMIQENYLRTKPMALTGKGYSQREHNLKALELFDNAAESISDGDLVDRMIHGPQQQWSLMPTHAVFSTVRPASFIAGQLLGSNFTSWLGNNSKFGRLGRSLREIHSHMRLRSSGDHNEIRQQYLPALWTQLVGRLQDQNNDAVGPVIDLMDSYFLTREDFDTVQELGVGQMDGDKVKIETKTKAAFTRTYNAMSHPVPFMKASNVTAPKAQPKEVPDLEEAVEDDDAEVVEAPEADEDDDEIDFKKDKYIKKPKAKKATKKTTKAAAAADDDDEEEKPKRGRAKAKATTIKAKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1RA62</accession>
    <name>I1RA62_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphoglucomutase</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Glucose phosphomutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">FG00387.1</name>
        <name evidence="20" type="ORF">FGRAMPH1_01T01013</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="21">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="22">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="21">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="20 22" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="20">PH-1</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate. The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate. Key enzyme in hexose metabolism. The reverse reaction is an essential step for biosynthesis because glucose 1-phosphate is the starting point for the synthesis of UDP-glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:68748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:68752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316049.1">
        <property type="nucleotide sequence ID" value="XM_011317747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RA62"/>
    <dbReference type="FunCoup" id="I1RA62">
        <property type="interactions" value="643"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RA62"/>
    <dbReference type="EnsemblFungi" id="CEF72309">
        <property type="protein sequence ID" value="CEF72309"/>
        <property type="gene ID" value="FGRRES_00387"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00387"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01013"/>
    <dbReference type="eggNOG" id="KOG0625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009330_0_1_1"/>
    <dbReference type="InParanoid" id="I1RA62"/>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03085">
        <property type="entry name" value="PGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000006">
        <property type="entry name" value="Phosphoglucomutase PgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="17">
        <location>
            <begin position="14"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="18">
        <location>
            <begin position="185"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="297"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CEF72309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="553" mass="59965" checksum="110CD3048B8CB3A9" modified="2012-06-13" version="1">MGVQTVEFKPFQDQKPGTSGLRKKVVVFQQPHYSEAFITSILLSIPEGVEGSNLVIGGDGRYFNPEAIQLIAKIGAAYGVKKLIIGQNGILSTPAASHVIRIRKATGGILLTASHNPGGPKNDFGIKYNLANGGPAPESVTNKIYEFSKTLTSYKIADIPDVDITTVGTQTYGALEVEVIDSTADYVAMLKDIFDFDLIKKFFSSHPDFKVLFDGLHGVTGPYGKAIFEQELGLSNSTQNCIPSPDFNGGHPDPNLTYAHSLVEVVDKHNIPFGAASDGDGDRNMIYGANAFVSPGDSLAIIAHYAHLIPYFKKNGVNGLARSMPTSGAVDLVAKAQGLDCYEVPTGWKFFCALFDAKKLSICGEESFGTGSDHIREKDGLWAVIAWLNIIAGVGIQNPEVTPSIKEIQKEFWTKYGRTFFTRYDYEDVDSEGANKVIGELEKLVADSNFVGSTIEGRKVTKAGNFSYTDLDGSVASKQGLYAGFSSGSRIVVRLSGTGSSGATIRLYIEQHTSDPSKYELDAQDFLKEEVKFATELLKFKEHVGRDEPDVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1RB45</accession>
    <name>I1RB45_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG00750.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T01893</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316459.1">
        <property type="nucleotide sequence ID" value="XM_011318157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RB45"/>
    <dbReference type="SMR" id="I1RB45"/>
    <dbReference type="FunCoup" id="I1RB45">
        <property type="interactions" value="1101"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RB45"/>
    <dbReference type="EnsemblFungi" id="CEF72747">
        <property type="protein sequence ID" value="CEF72747"/>
        <property type="gene ID" value="FGRRES_00750"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00750"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01893"/>
    <dbReference type="eggNOG" id="KOG3582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126658_3_0_1"/>
    <dbReference type="InParanoid" id="I1RB45"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="PHI-base" id="PHI:1301"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF39">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="28"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF72747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="121" mass="13796" checksum="37B1E7D0CB0464C0" modified="2012-06-13" version="1">MSSPNNKSPSALNLDGAGDEKPRLTEEEKKQNHIASEQKRRQAIREGFDRLTELVPGMEGQGRSEGLVLKRTVDYMHDQIAERQRLIARIEAAGGQVDEQHKRVLYQQAQQFSNLQNQTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>I1RBC7</accession>
    <name>I1RBC7_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">FG00843.1</name>
        <name evidence="22" type="ORF">FGRAMPH1_01T02111</name>
    </gene>
    <organism evidence="22 24">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="23">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="24">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="23">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="22 24" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="22">PH-1</strain>
        </source>
    </reference>
    <reference evidence="23" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_011316563.1">
        <property type="nucleotide sequence ID" value="XM_011318261.1"/>
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    <dbReference type="AlphaFoldDB" id="I1RBC7"/>
    <dbReference type="FunCoup" id="I1RBC7">
        <property type="interactions" value="894"/>
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    <dbReference type="STRING" id="229533.I1RBC7"/>
    <dbReference type="EnsemblFungi" id="CEF72855">
        <property type="protein sequence ID" value="CEF72855"/>
        <property type="gene ID" value="FGRRES_00843"/>
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    <dbReference type="KEGG" id="fgr:FGSG_00843"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02111"/>
    <dbReference type="eggNOG" id="KOG0215">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_000524_5_1_1"/>
    <dbReference type="InParanoid" id="I1RBC7"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:termination of RNA polymerase III transcription"/>
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        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
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        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
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    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
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        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
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    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
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        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
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        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
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        <property type="entry name" value="RNA_pol_Rpb2_7"/>
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    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RNA_pol_Rpb2_1"/>
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        <property type="entry name" value="RNA_pol_Rpb2_3"/>
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        <property type="entry name" value="RNA_pol_Rpb2_4"/>
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        <property type="entry name" value="RNA_pol_Rpb2_6"/>
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        <property type="entry name" value="RNA_pol_Rpb2_7"/>
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        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
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        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="43"/>
            <end position="418"/>
        </location>
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    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="193"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="455"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="557"/>
            <end position="618"/>
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    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="639"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="686"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1064"/>
            <end position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00053978"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00562"/>
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    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CEF72855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1157" mass="130801" checksum="AD64E8AE4AC07593" modified="2012-06-13" version="1">MPTVDDGFEALLEPFYNGKKLTDPISTKEDKFQLLPAFLKVKGLVKQHIDSYNFFVEHEIKDIVRANRTIRSEVDSNFWLEFTDIRVDKPRRQDWQDAKSHTEVTPMECRLRDMTYAAPISVDIQYIRDKQRIVRKNVPLGRMPVMLKSSICRLGGANNTKMEEMNECPLDPGGYFIIGGTEKVILIQEQLSKNRIIVEADEKNNIISASVTSSTHERKSKTYVTLKKDRILLTHNVLVEGIPIVIILKALGGLSDMEIMQLVAGSDGRYQDEFLVNFDEATKVGVFTQHQALEYIGTRVKMAPRRGIFGPQVRRNHVEEGLDALANLVIAHVPIEGLDFYPKAIYVAMMTRRVLIAAHNPKLVDDRDFVGNKRLELAGQLLSLLFEDLFKQFTTNVRMSIDKFLKKNNRAVPLDAVNMISNHANNIGYGINRAIQTGNWNVKRFNMNRAGVTHVLSRLSYIAALGMMTRISSQFEKTRKVSGPRALQPSQWGMLCTSDTPEGEACGLVKNLALMTHITTNVDEEPVKRWIFTLDAGVEPIRNFSGAEMHREGSYIIHVNGTPFALTRYPKRFAQKFRTMRRRGWISPFVGININTHFNAVHIATDEGRICRPYIIVKNGKQKLKPEHLRLLQMGKATFDDFLNRGIVEYLDVNEENDALITIYEHQVTQSTTHLEIEPFTVLGAVAGLIPFPHHNQSPRNTYQCAMGKQAIGAIAYNQFNRIDTLLYTLVYPQRPMVISKTIQLIGYDKLPAGQNATVVVMSYSGYDIEDALVLNKASVDRGFGRCQVFRKYTTELQKYPNGRRERIGDPEMEGEGKSKRRITKHEALDDDGLAIVGYKVHSGEAMVKKETPLDQTSTGIGLDRGPGEFRDSSVSYRIADPAYIDKVMISQTEKDTTVIKVQTRQTRRPELGDKFSSRHGQKGVVGIIVEQEDLPFSDSGLSPDIIMNPHGFPSRMTVGKLLECLTGKASIIHGRPDYGFGDAFRSHPLEEMSQVLVDHGFSWEGKDYFTSGITGEPLEAYVFNGPIYYQRLKHMVQDKMHSRSRGPRAILTRQPTEGRSRDGGLRLGEMERDCLIAYGASQLLLERLMISSDGTEIDICQQCGLFGYKGYCHTCKSTREVTKMTMPYAAKLLVQELISMNVGVRLQMDDEFPHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I1RCK4</accession>
    <name>I1RCK4_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG01323.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T03271</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317110.1">
        <property type="nucleotide sequence ID" value="XM_011318808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RCK4"/>
    <dbReference type="STRING" id="229533.I1RCK4"/>
    <dbReference type="EnsemblFungi" id="CEF73440">
        <property type="protein sequence ID" value="CEF73440"/>
        <property type="gene ID" value="FGRRES_01323"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01323"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03271"/>
    <dbReference type="eggNOG" id="KOG1964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005882_1_0_1"/>
    <dbReference type="InParanoid" id="I1RCK4"/>
    <dbReference type="OrthoDB" id="3098at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF73440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="907" mass="102979" checksum="FBBD0C70C69CC01D" modified="2012-06-13" version="1">MAPIETENFLSYEAGPEVEEFANALDDCLSLPLSTEERRERILDLPRKYYENSLRRLAQVRPRMVRDGQDDVDMDADEIDPVNNNPASAELIKRLEKEAQTWDLLRRLLPLRYPSSEVDEKTLGTKHGLQDPEDLLGNFLISDSSARERQAVIQWLQNNAASGPDIDELARELQQNADRGDIIAHGWLHTRSQIKLRKSVTAWPHLLDRQSPAIATSFHNSDGSPLVTQLDPDAATRQGRKLEPQDEYFERAIWLGCFEHLRRGSSLETIREWCQERTEMWRAISTSAVLVSADDTQTFSNTNPASLALWRRMCFSLSRSGGCDDYERAVYGVLSGDISTVEKIALTWDDFLFANYNALLRTQLDNYILGQCPPDVASNLTQSFPSFDAVQFHGEPETVDKRLIRALESNPQIRAEANEPNKALQASLVAKEIGRHLYEQGVVISSSANQSESNLFRWKPENIELNKEKFFQSTQHYGLRIVAHIYLLINLLDKLHSNDDSLAPASSQPGVRRAQQNLLAGYANYLRLAQLQELIPLYCSILEPPRSYEVLSYNLIPESDNQQRLLQLKLIKKAGIDVLQFVKTQAWLMYDDLGPPQHGCPANGSFSIIAPGPPTARRGRPVKADFFGDDEKFIDTAHENLIRSLEWLLLVQETWPSVFSMGTRIYKFFLRNMHLNAARQLMKRVSFTDVLQAATEDSSEEMDMYEDIPEFWAKQLERRDIRDVTPQQALSDARKFRELENLVRALDSLETVASLAELTNEEQKKNAGFWPAIGEEVKNTRENMQPLLKGWLLVGIEEGDQELRDLREAYLSETVLAYIGTLHFAGTGLSRDNLLECMELASVVAERDSDLSTAFVEARRMKELVEVFAACSKALAISTTGERRTTGTSSKKVRELGWSRDLWSVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1RD11</accession>
    <name>I1RD11_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG01498.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T03671</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317307.1">
        <property type="nucleotide sequence ID" value="XM_011319005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RD11"/>
    <dbReference type="FunCoup" id="I1RD11">
        <property type="interactions" value="192"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF73641">
        <property type="protein sequence ID" value="CEF73641"/>
        <property type="gene ID" value="FGRRES_01498"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01498"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03671"/>
    <dbReference type="eggNOG" id="KOG2861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011220_3_0_1"/>
    <dbReference type="InParanoid" id="I1RD11"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF4">
        <property type="entry name" value="SPORULATION PROTEIN RMD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="321"/>
            <end position="507"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF73641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="629" mass="70811" checksum="13CEAF43B83A54FC" modified="2012-06-13" version="1">MSSKRGPSVLVTDARQRQPQRRVLQRQDTGAGAPGSQAPMRFMTVDNVLQYNSQIPSGQPRGPPGPATLPSGRHPGPPGSALSRRVSSGGLPNSQSRTGQQIPSRTTKISEKLVLLPEAEDNGDDVDEEIESESILARRVQDDENRPLKDEELDVLKKRGGVRGKSFAERLSKTQRTDKVSRLTAYCTAQAYKIKPTAEFLRKKHEAKTKIYDDCLYVIYALPLLNGNDGTRIRSRPILKTPGTGKTVLDLEIERSEQRDHHEGYFDDDAYEHPSPDRGHEIPARFTDRPSTPERSNPFHHDDDVSSMNRLAPDAKNFAEMFVYSYGVVVFWNFTEHQEKDILADLTFADADAVENGATSLLTRPLDQEDYETEEFHFEYSADIKRPRIFNDMITLLPKSDHMIKLTISHAIAQSTRLCFFEERMSETMLDAQHVPKMLALTGELKMTRTEIVRMLGKLFRSRVDINLSSNILDVPNFFWESEPTLHPLYAAIREYLEIDPRIKVLNERCRVFLDLAEILSDSVADAKMSYITWIIIVLIILSIMVTTAEVGIRFGMLNKAKGTNVNRIITAPVLGHGMEQTVLPPSDLEILAQTLGLQANASFEDVHKSIWALQGKDLPNASILHEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1RDV7</accession>
    <name>I1RDV7_GIBZE</name>
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        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="primary">FG01825.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T04417</name>
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    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317667.1">
        <property type="nucleotide sequence ID" value="XM_011319365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RDV7"/>
    <dbReference type="EnsemblFungi" id="CEF74015">
        <property type="protein sequence ID" value="CEF74015"/>
        <property type="gene ID" value="FGRRES_01825"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01825"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04417"/>
    <dbReference type="eggNOG" id="ENOG502SMIF">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_092842_0_0_1"/>
    <dbReference type="InParanoid" id="I1RDV7"/>
    <dbReference type="OrthoDB" id="3923682at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009267">
        <property type="entry name" value="NTP_transf_6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39166">
        <property type="entry name" value="BLL1166 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39166:SF1">
        <property type="entry name" value="BLL1166 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06042">
        <property type="entry name" value="NTP_transf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF74015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="198" mass="23014" checksum="F39E5A8D1E0D40D3" modified="2012-06-13" version="1">MDASLLPLNDQISRFKETVKHNKTLMVVLSRAAEMKLPNWYLAAGALTQTVWNVMTNRDPEQGIDDYDLIYFDASDLSWEAEDAVIQKGKELFKDIPVEVEIRNQARVHLWYEKKFGRPCPQHHSSEAAMTAWGTNTALIGVSLRDDGEWDIFAPWGLSDMFTLVVRPNQQIMTEETYNKKTQRWIKLWPEITIMPWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1REU3</accession>
    <name>I1REU3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG02194.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T05285</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318081.1">
        <property type="nucleotide sequence ID" value="XM_011319779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1REU3"/>
    <dbReference type="EnsemblFungi" id="CEF74447">
        <property type="protein sequence ID" value="CEF74447"/>
        <property type="gene ID" value="FGRRES_02194"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02194"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05285"/>
    <dbReference type="eggNOG" id="ENOG502RJ83">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1825389_0_0_1"/>
    <dbReference type="InParanoid" id="I1REU3"/>
    <dbReference type="OrthoDB" id="5132974at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF74447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="137" mass="15340" checksum="6C755E5C7920C0AF" modified="2012-06-13" version="1">MISNGSAPTDQQGLKPWHRWALDRGRTPLPEKAGARPWETKSTNTSQDQTSSGNTPGSAPSSGDGTNQSASQPTTTVAAYPYRFWPTEEIERLIRLRRDGLSWNQIKDHFPDRSLESLKQTYHKRRAAVEAEMDASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1RF08</accession>
    <accession>A0A098D6F5</accession>
    <name>I1RF08_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="3" type="primary">FG02270.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T05479</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318176.1">
        <property type="nucleotide sequence ID" value="XM_011319874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RF08"/>
    <dbReference type="STRING" id="229533.I1RF08"/>
    <dbReference type="EnsemblFungi" id="CEF74544">
        <property type="protein sequence ID" value="CEF74544"/>
        <property type="gene ID" value="FGRRES_02270"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02270"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05479"/>
    <dbReference type="eggNOG" id="ENOG502SPRK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039760_1_0_1"/>
    <dbReference type="InParanoid" id="I1RF08"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF9">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="185"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF74544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="441" mass="50856" checksum="3B8EA659CE3B983F" modified="2012-06-13" version="1">MTFDPGSPCSSDTRGRRWKEYSQAQLKKLPVLPNPRPRALTPDPFLGSGANRAPIPRYQESCFWFKVPPNIRRDIIRLAFGDTRLHLFIDWDYLDVPRQPSQKLHCGIARGPLDDENMAKRRIKRLKDETQPEKWQWWGSRCHRIHPSDDGTLGPMTRGGSLGPWADYCRSGGSPDICEAWRRQDGPSACHIGVMGWLLSCRQNYFETIDILYSTNTLILEDTCVLNSLPKILLPQRLELVTSLEITWPLRSCKTPSSREFWEDLDVRNLDIMLDFVSPSKFPALGRLYVYLPLEDYHDLFPHDHSDHMDIIMNRLDSCVRRMTRLTECSFALPTDLFEEILDDAKETHREVMVGYDVTVRLDSYKQIWRDVDGNMATTKLPCLDSYPNRPYHLSQDVEGTAGYWILEASEEAVYFSHLEELRAKGAVFQCGPEPNPVGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1RFG3</accession>
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    <name>I1RFG3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
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    <gene>
        <name evidence="2" type="primary">FG02437.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T05849</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318358.1">
        <property type="nucleotide sequence ID" value="XM_011320056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RFG3"/>
    <dbReference type="EnsemblFungi" id="CEF74729">
        <property type="protein sequence ID" value="CEF74729"/>
        <property type="gene ID" value="FGRRES_02437"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02437"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05849"/>
    <dbReference type="eggNOG" id="ENOG502SQU9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046563_0_0_1"/>
    <dbReference type="InParanoid" id="I1RFG3"/>
    <dbReference type="OrthoDB" id="3219467at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF74729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="342" mass="37342" checksum="A95F532046314A52" modified="2012-06-13" version="1">MALSRGQALSTYVSGIKMSPGTSPTSWTAFNGTKWNASQGNASNGNQSFYVGPRGGPLVAAIVAPGTNPSALVYDDKLYCFFIGTDGTGTCYVTVQEGKIVAPVSLSKLNTGMPFQPQTSPNPLVLLENYAVRWFWVEKASQTLWYSDYRTDGGDWSPLKKLSCDGDVPKLAISTNITAVQFLNKPCIFWNYGTGISFCAGFVWEISDTTSAKPTQLLQESDCFTVSTSDSTLVTLLRSELGNGPTAREFIPVSPRPATATGEIAFVCPRPAEVVSDFTKSVYSKFDVTSSTPLATKISITTTLLANAFKLPYIIILKFQQQKATLRFYRYRQSLLRFLCDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RGL6</accession>
    <accession>A0A098DGJ6</accession>
    <name>I1RGL6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG02887.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T11543</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322917.1">
        <property type="nucleotide sequence ID" value="XM_011324615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RGL6"/>
    <dbReference type="STRING" id="229533.I1RGL6"/>
    <dbReference type="EnsemblFungi" id="CEF77575">
        <property type="protein sequence ID" value="CEF77575"/>
        <property type="gene ID" value="FGRRES_02887"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02887"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11543"/>
    <dbReference type="eggNOG" id="KOG1584">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027239_3_0_1"/>
    <dbReference type="InParanoid" id="I1RGL6"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="BRENDA" id="2.8.2.1">
        <property type="organism ID" value="2428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="4">
        <location>
            <begin position="36"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF77575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="307" mass="35899" checksum="DE896670F6D569A0" modified="2012-06-13" version="1">MANMNGDEKKIPQKTREVSNHHMDSTVWNDVKLRSDDIIISTYSKSGTTWVQQIVSQLIHKGDPTVAAGALSPWVDIRIVPREVMLEMVEAQTHRRFMKTHLPVDSLVWDPKVKYIFIARDGRDMIWSLHHHFYTATPTFYSFFENTGIAPFERPSENPRDMLIDLIEDDTRPTICWPFWSHIRGWWERRDQPNLMLVHFNDLKKDLEGEIRKIAKFLETPDMAEDKFKDVVEHCTFDWMKEHAELAAPPQAAVAWENGARDFVNKGSNGRWRDVLSEEDNKRYLDKAREELGEECANWLQNGGSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RHC7</accession>
    <accession>A0A098DG63</accession>
    <name>I1RHC7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG03173.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T12229</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322592.1">
        <property type="nucleotide sequence ID" value="XM_011324290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RHC7"/>
    <dbReference type="STRING" id="229533.I1RHC7"/>
    <dbReference type="ESTHER" id="gibze-q4ihy5">
        <property type="family name" value="Haloacetate_dehalogenase"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF77918">
        <property type="protein sequence ID" value="CEF77918"/>
        <property type="gene ID" value="FGRRES_03173"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03173"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12229"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_7_1_1"/>
    <dbReference type="InParanoid" id="I1RHC7"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="33"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF77918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="300" mass="33561" checksum="FCBB307B1E73C89D" modified="2012-06-13" version="1">MFNNFQPFTIQTKSDPNVTINGLKSGDASSSKPALLLIHGFPQTLHIWHRVVPQIADKYNIVLIDIRGYGKSSKPAGVASYAKSAMARDCIDVMDALGHSGSFFVCAHDRGARVAHKLAVDYPDRIRKFILLDICPTLAMYTKTDFDFAIAYFHWFFLIQKEPLPETLITAKPRELAKMFMGGRQGDGVAIFEPDCFNIYAKSLEDYDTVHGMCNDYRASATLDLEEAREDLKNGKKIKSPLLILWGKHGVIEKCFDAIKEWKEVTEDGVSVQGHSVDSGHYIPEQAPDEVVASIKEFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I1RHG2</accession>
    <accession>A0A098DHN8</accession>
    <name>I1RHG2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG03214.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T12335</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322544.1">
        <property type="nucleotide sequence ID" value="XM_011324242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RHG2"/>
    <dbReference type="FunCoup" id="I1RHG2">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF77970">
        <property type="protein sequence ID" value="CEF77970"/>
        <property type="gene ID" value="FGRRES_03214"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03214"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12335"/>
    <dbReference type="eggNOG" id="ENOG502R94Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009030_0_1_1"/>
    <dbReference type="InParanoid" id="I1RHG2"/>
    <dbReference type="OrthoDB" id="5089701at2759"/>
    <dbReference type="PHI-base" id="PHI:1910"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF77970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="737" mass="82656" checksum="207E97857F00F7D3" modified="2012-06-13" version="1">MGTSSRSRRTHSFGGCKTCRKRHLKCDQSLPKCNRCTQAGLACEGFTPALRWLISTGREVYDRQPTQAAEVGAEQYSRRHLFTEADRELMSNALLKNVPYTVTAALNQIDEESKGLDVHDDAASICEVGPFQVFKFESSQSATTAVSDHVSFNEMDLDTLSEPQTQDFSEPIDNDPDQLVDETVVPNDFSTTSLDFLHWGDLFTWDVSVLDNPPQLPYENFDALPMNINWPEESFSESLDAMIPFEPVTDDVAWPQLDLKTDAPLLLKHFNDDVISQMGSLPINEKSAWRTLHYPSAIMTLSELTMLEVNKDQIKRANLSTFYALIAVSAFHLSLNPITFPSLARPGDHWESVSSRAYEAAKQHLRVSLEKESQPGPNKAKYKEQLMGISAVLATALLSGNETDTRWCLTEMERLISWRGLTKPSISRRARLLHNIYAWMRIVSESLNVFHDENHAIETPFTRSNGNGSANTSKSAAVPVQSINPDMTLDNFLHLEPRKLHGQKAKRDIKDIHLADVSQDHENMYMQIYGVPETWLSLVSQITRLANVMDRLSAQKKPDAEALMALQPRASYLENAVCLFRSRHGKGSPSMSASPSSAPGGTPHMHMVRALASALVIFFYRRIRKVNPLVLQDSVNDVVDSLHAFDEALERNNLLGPGTAWPAFIAGAEARGRQRIDIAEWLDKGFSRSGFESYKSSKEVLSEVWRRRDAAGGGMPNGDVCTWMEVCRDLRRWPLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RI80</accession>
    <accession>A0A098DHD1</accession>
    <name>I1RI80_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG03507.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T13049</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322203.1">
        <property type="nucleotide sequence ID" value="XM_011323901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RI80"/>
    <dbReference type="STRING" id="229533.I1RI80"/>
    <dbReference type="EnsemblFungi" id="CEF78328">
        <property type="protein sequence ID" value="CEF78328"/>
        <property type="gene ID" value="FGRRES_03507"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03507"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13049"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_5_4_1"/>
    <dbReference type="InParanoid" id="I1RI80"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13850">
        <property type="entry name" value="CuRO_1_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13876">
        <property type="entry name" value="CuRO_2_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF488">
        <property type="entry name" value="LACCASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124271" evidence="8">
        <location>
            <begin position="25"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="34"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="176"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="447"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF78328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="590" mass="65663" checksum="E62B3B3F572D17A5" modified="2012-06-13" version="1">MTTIRLCTTSFVLSLLLLGDFVSGLRRYNFTITSQWSAADGHGRPVFAINGQTPGPLITATEGEEVEVFLNNQLATETTMHWHGIYQVDRPWNDGVPGVTQYSIQPRDNYTYRFTVQQQYGSYFYHGHFGPAFADGQRGPIWIEPAAWRPRPYKAISSSPQDLKAMQRAEVNPRHIVISDWNAEPMDILLIMYRDTGIVPWCSNSIVMNGKGRTYCHSKELIEETGGSGRNSLGCKVQPKQGLYANAQVCEPTNGELEVVAAADGEEWIWINFIHSGAHHELQISVDEHEFYVVAADGEFVHPQKVHAANCNLGERLSILVHLNKSPGDYAIRLTSLRTEQVIQGLGILRYPSKTNNKITKVPTSKPWVHLNGTLISTSSTSMDEMKLAPFPARPPPWTSDQTVKLFINMTGPSAWSLGLGSHQAFRQQLPPVLWEENSRGGTTLGVQNVLRNGSVVDIIFENGANVTSQHPFHKHNHKAWIIGTGHGGFPWETVQEAIDAGAADYFNFNDPPIRDGCRLGNATGDWTVIRYEITFPAASMLHCHMIHHFGAGQQIVLLEGVEAMAQVPNEVKQKVHADFVPNLRYGPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RIM7</accession>
    <name>I1RIM7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG03667.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T13423</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322030.1">
        <property type="nucleotide sequence ID" value="XM_011323728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RIM7"/>
    <dbReference type="STRING" id="229533.I1RIM7"/>
    <dbReference type="EnsemblFungi" id="CEF78515">
        <property type="protein sequence ID" value="CEF78515"/>
        <property type="gene ID" value="FGRRES_03667"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03667"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13423"/>
    <dbReference type="eggNOG" id="ENOG502QU2V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046727_1_1_1"/>
    <dbReference type="InParanoid" id="I1RIM7"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="9">
        <location>
            <begin position="38"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="8">
        <location>
            <begin position="121"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF78515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="301" mass="33486" checksum="08CCFA4C2A2DFD62" modified="2012-06-13" version="1">MSPSAEATGGNASGAPKEEGLGQAFTQQVIDSFGPKTDPRLRELMSSFIQHMHDFARETQLTCDEWMTAVNMINWAGQMSTDKRNEGQLMCDVIGLESLVDDITHRQAVKNGFSGTETAILGPFWRQDTPIRENGTTITFDTPSDGKVAYLYGTVTSATTGKPIPNASVDVWQASTNGLYEQQDDKQVEHNLRGKFITDDQGRYSFYCLRPTPYPVPQDGPAGKLLQKLDRHVFRPAHLHFMVIAKGYNSVVTQIFDSDSGYLDNDSVFAVKDNLTVTFVPRKGDPQAEWELEYNMTLATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1RKW9</accession>
    <name>I1RKW9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG04540.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T15543</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321047.1">
        <property type="nucleotide sequence ID" value="XM_011322745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RKW9"/>
    <dbReference type="EnsemblFungi" id="CEF79573">
        <property type="protein sequence ID" value="CEF79573"/>
        <property type="gene ID" value="FGRRES_04540"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04540"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15543"/>
    <dbReference type="eggNOG" id="ENOG502SQK5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_813837_0_0_1"/>
    <dbReference type="InParanoid" id="I1RKW9"/>
    <dbReference type="OrthoDB" id="5211520at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF79573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="308" mass="36287" checksum="B61148A0CCECAE1D" modified="2012-06-13" version="1">MSAIRGFLNVFKARSVPVPAGRIINLKPLSDSTSNTRVGTAFLERCNPFRDIPNDARLENTLCEVRYIDRTLRDLMVPTSLPGDDYNLCSKLLRSLETRRDLTWLVLRETDIRDTVSAIARRGGRRAPIPDEPHDLHSRVKALERHWSALEKCHTKLREWEPKYATQPQPPLLEGQEAYDLELNDEQATHAEIEYREWRSDRDRKVSYLKLNPPEPSAFVPVERRDIQTDETWNILPTSKGHYGKRLLPVWTPILFQEVPLDWENPQGPLLSTRAERRRRDQFRRRENNRREKKYEFQKQLRQQMSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1RKX2</accession>
    <name>I1RKX2_GIBZE</name>
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        <recommendedName>
            <fullName evidence="8">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG04543.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T15549</name>
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    <organism evidence="11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="8"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321044.1">
        <property type="nucleotide sequence ID" value="XM_011322742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RKX2"/>
    <dbReference type="FunCoup" id="I1RKX2">
        <property type="interactions" value="451"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RKX2"/>
    <dbReference type="EnsemblFungi" id="CEF79576">
        <property type="protein sequence ID" value="CEF79576"/>
        <property type="gene ID" value="FGRRES_04543"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04543"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15549"/>
    <dbReference type="eggNOG" id="KOG3396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072095_0_1_1"/>
    <dbReference type="InParanoid" id="I1RKX2"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000048">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF79576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="177" mass="19646" checksum="CA7716D57D91181A" modified="2012-06-13" version="1">MVTTGPLFPPDLIGADVVSSFPQGYTIRPLERGDYAKGFLDCLSVLSDVGNVSQDQFEERFDWMKIQGQGVHFHVVIEHENRIVGTGAIIVERKFIHNLGLIGHIEEIAIGKDFQGKGLGLKLLASLSSIAKNVGCYKTTLGTSPDNEPFYVKCGYNKSGNIMNQYFEEPKEPYYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1RLG1</accession>
    <accession>A0A098DZK9</accession>
    <name>I1RLG1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG04758.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T16247</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323200.1">
        <property type="nucleotide sequence ID" value="XM_011324898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RLG1"/>
    <dbReference type="EnsemblFungi" id="CEF86303">
        <property type="protein sequence ID" value="CEF86303"/>
        <property type="gene ID" value="FGRRES_04758"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04758"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16247"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_9_1_1"/>
    <dbReference type="InParanoid" id="I1RLG1"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965:SF12">
        <property type="entry name" value="ASPARTIC PROTEINASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965">
        <property type="entry name" value="ASPARTYL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124364" evidence="9">
        <location>
            <begin position="22"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="10">
        <location>
            <begin position="43"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="313"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF86303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="405" mass="43788" checksum="DD464D21179F7B1E" modified="2012-06-13" version="1">MAGSALRAAFTAAVAVQSVSAATKTPAGVIALPLTRDDGLTAYFAKLQVGTPLQTQHLKIDTGSPRYSFLDPRNGVCQREGDPCVEYGTFNNETSSTCQYAGTNFADALGYVGRGDYLSDTVVFGGVATKNMYFGYTSDYSFPDKLSGDIYTILGLSLECGYDFAGPECTYRSSSYALPELKNASTINYMASSIYLGPDDKEAANAQMLLGGAYDKAKIDGDLITVPMVDPFNVQLTGGQTNSVNVTSLEVFLSKDNNKTTETYGEKGVGLPVLMDTGVAAWYLPDKIMAPIYRAFEVTEEPPLGQRYFVVDCKYADPKRSDGYISVGFGNYGKIKVPLHGVVSKFPDKTCGVFTASRGDTVSIFGDPFLRNVYSIFDQENWTLSMGHVKHTDEEDIVPLPKGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1RM43</accession>
    <name>I1RM43_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG05022.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T16901</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323504.1">
        <property type="nucleotide sequence ID" value="XM_011325202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RM43"/>
    <dbReference type="EnsemblFungi" id="CEF87059">
        <property type="protein sequence ID" value="CEF87059"/>
        <property type="gene ID" value="FGRRES_05022"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05022"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16901"/>
    <dbReference type="eggNOG" id="ENOG502RJMA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_969934_0_0_1"/>
    <dbReference type="InParanoid" id="I1RM43"/>
    <dbReference type="OrthoDB" id="5398270at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041622">
        <property type="entry name" value="SLATT_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033635">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793">
        <property type="entry name" value="SLATT_FUNGAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793:SF1">
        <property type="entry name" value="SMODS AND SLOG-ASSOCIATING 2TM EFFECTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18142">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="SMODS and SLOG-associating 2TM effector" evidence="3">
        <location>
            <begin position="97"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18142"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF87059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="287" mass="32092" checksum="BB91C9D5B6DC19B2" modified="2012-06-13" version="1">MSATPVLKVPAMPLLYLDSSQPQTPDCNACVQSNNPKHPKPMETPEYRRLSHSEWKFFAAGVGGIRDKEHDAPISPTSSFWPPKGLPPGLYRDTIYRRTICHYSFHFTAYVRWILLILQLILGAALTALGPMSLEKGTPITILGASNTVLAGLLALFTHSGLPDRYRYDKAEFERVEDHIREILVTGLVRAEKSVNEALAECYDRYRHAKATVEVNVPTAYIPSQSVPPGQRHQPTQVNEANDPITPTKSHRPSLHKEPITPIRTQSRNTTPKEETEEKGPVTRIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1RMA4</accession>
    <name>I1RMA4_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
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        <name evidence="3" type="primary">FG05089.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T17075</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323583.1">
        <property type="nucleotide sequence ID" value="XM_011325281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RMA4"/>
    <dbReference type="STRING" id="229533.I1RMA4"/>
    <dbReference type="EnsemblFungi" id="CEF87915">
        <property type="protein sequence ID" value="CEF87915"/>
        <property type="gene ID" value="FGRRES_05089"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05089"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17075"/>
    <dbReference type="eggNOG" id="ENOG502SERQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038857_1_0_1"/>
    <dbReference type="InParanoid" id="I1RMA4"/>
    <dbReference type="OrthoDB" id="2896006at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="147"/>
        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF87915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="362" mass="39523" checksum="A7119E6146DAEC5F" modified="2012-06-13" version="1">MISETAMSLMRRDNMPKPNLGHEINQLPDWSFYVFLANFILFFPVLLLCSYTFEKVFPVLAIVEDEKPPAYAPLAVESIANDDITKPSGVPSAPAAAGHGKPITSSFRATFSLLRSTGGFRAMYRGYLMHALQALALGLIMSALSHVTPYSFAVAHLISSLICVQLSTAWVHIVITPESQDPWYRRIPAFKTTFLATWRPIVIWWAASQVVTLGGITTVYAMGTDSQGMPEFDGSESGVWGIMILALFLQVAIQIPAYVVLVRVQASLLPAEADTIIPFDRSFNGRIEPVVVGGRGYATVRDAWSSFSKSAWKRIVMLEIKIIAVTVASFFALMVVVIPQIILLATLSASTGDNPGNGDMGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I1RN04</accession>
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        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 7</fullName>
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        <name evidence="13" type="primary">FG05360.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T17725</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323885.1">
        <property type="nucleotide sequence ID" value="XM_011325583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RN04"/>
    <dbReference type="FunCoup" id="I1RN04">
        <property type="interactions" value="735"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RN04"/>
    <dbReference type="EnsemblFungi" id="CEF86883">
        <property type="protein sequence ID" value="CEF86883"/>
        <property type="gene ID" value="FGRRES_05360"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05360"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17725"/>
    <dbReference type="eggNOG" id="KOG0570">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065214_0_0_1"/>
    <dbReference type="InParanoid" id="I1RN04"/>
    <dbReference type="OrthoDB" id="10253553at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF86883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="246" mass="27888" checksum="30CD95E24D39019D" modified="2012-06-13" version="1">MAEQQQEAQALSSMFPNPPPFWQEFTPERISRIQELRTPYTAENGGDPLTVRVPDVPEDLISLQPPAEPADGRWRVFGDQYMLDDKLPTLEDQGITNLPSSSQSESKDAKRFDRAFELKRLAKSLLLNFLELSGTLSRNPSHAEAKVQDLRTLFINFHHILNEYRPHQARESVIALMQEHLDRTRTETMAIRTQVDKARRVLDGLGSLSVPDVPTALGQQADEQNRDALAKQREADVWATTDALFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>I1RN70</accession>
    <name>I1RN70_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FGRAMPH1_01T17911</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Cytoplasmic vesicle</location>
            <location evidence="10 11">COPI-coated vesicle membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Golgi apparatus membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323974.1">
        <property type="nucleotide sequence ID" value="XM_011325672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RN70"/>
    <dbReference type="FunCoup" id="I1RN70">
        <property type="interactions" value="1167"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RN70"/>
    <dbReference type="KEGG" id="fgr:FGSG_05436"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17911"/>
    <dbReference type="eggNOG" id="KOG2635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019988_3_0_1"/>
    <dbReference type="InParanoid" id="I1RN70"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="13">
        <location>
            <begin position="289"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="155"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SCB64755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="527" mass="58050" checksum="9F322FD735C5F6B5" modified="2012-06-13" version="1">MVVLAASICTRGGKAVLSRQFREMPRSRIEALLASFPKLADSGTQHTIVEQDNVRFVYQPLDELYMVLITNRQSNILQDIDSLHLFAQVVSSTCKSLDEREIVKNAYELLSAFDELVTLGYRENLTISQIKTFLDMESHEERIQEIIARNKELEATEERKRKAKQLEMQRKDAARSGRPAAGAMGGMGGGMGSSGGMPRSPSYPSYNPPSQSNTSTYDSYEAEKNKSFGKPLAPKAKGMQLGKKSKTTDMFERVRGDMGSEIDHSPLVTPAPQQQAETPEPRVSSTLDRDAIHIAISETISAKLSREGAVNSLAVSGDLVLRISDPSLTKIKLGLQAVASHGVQFRTHPNVDRNLFNSSKVIQMSNTARGFPVNNAVGVLRWRASPKVDDPSACPITFTVWINKDADKYNITVEYELTGGDALNDVSVVIPYAGSEPVISSYDATYDVSGDAIEWSIGNVDDENSTGSFEFEAESGDENDFFPMTVRFNKSTPYIDVDVNTASLLEEDEEVTFSKEVKSHADNFLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1RN72</accession>
    <name>I1RN72_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG05438.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T17915</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GSE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323976.1">
        <property type="nucleotide sequence ID" value="XM_011325674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RN72"/>
    <dbReference type="FunCoup" id="I1RN72">
        <property type="interactions" value="585"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RN72"/>
    <dbReference type="EnsemblFungi" id="CEF86095">
        <property type="protein sequence ID" value="CEF86095"/>
        <property type="gene ID" value="FGRRES_05438"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05438"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17915"/>
    <dbReference type="eggNOG" id="KOG3887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047421_2_0_1"/>
    <dbReference type="InParanoid" id="I1RN72"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11385">
        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000005">
        <property type="entry name" value="Gtr1 g domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000643">
        <property type="entry name" value="Small monomeric GTPase (Gtr2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF86095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="397" mass="44550" checksum="FC508B82B6950DDF" modified="2012-06-13" version="1">MSLSPPVHNFSRSFDEADDTSASGTSPAQLNLQRLFEQSLGGASASKKDVQNPATPAPSSAGAPPKGKPRLLLMGQRGSGKSSISSVVFHKLPPNETLFLESTARIQKDSMASFMDFQVWDFPGQIDVFENPGFDIEAIFSEIGALIWVIDAQDDYLEAVMRLNTTILFLQRTYPNINIEVFIHKVDGLSDDYKLDIQRDITIRIQDELSDHGFENAPVTFHLTSIYNHSIFEAFSKVIQKLIPRLGTLESMLTNLCRTCRFEKAYLFDVLTKIYIATDSATADMASYEICSDYIDVIIDITEVYGTWQRSDEGRRRLEGEPWSTPIDKQIGCNTAESCLVLHDGNKPIMLREVDRYLALVAIMKEDSYDSMPLVNMNVEAVVEGLTEFFNITKPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1RNM1</accession>
    <accession>A0A098DXP3</accession>
    <name>I1RNM1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG05604.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T18313</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CEF86625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_011325862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RNM1"/>
    <dbReference type="STRING" id="229533.I1RNM1"/>
    <dbReference type="EnsemblFungi" id="CEF86625">
        <property type="protein sequence ID" value="CEF86625"/>
        <property type="gene ID" value="FGRRES_05604_M"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18313"/>
    <dbReference type="eggNOG" id="ENOG502SCZV">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
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    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        </source>
    </evidence>
    <sequence length="322" mass="35911" checksum="7DFCF9B9DA89ADE5" modified="2012-06-13" version="1">MSTTTVNIIEWTEFANLYAKVNGVSLTTPPPSPPGLDNFILSPQDIRDTISARKGHHSNSMSYTCNYEPTSSYPVLEGFPPGFPPGFPPSPSPPPTTSVPSTPGSSRHSSPPVTPTSSPADDPPSWRCGPRRERPRPSFSPSPDRPFSTYNRSTYKRAPKQPAAKKDGCLGLPVQTYVLTEIQTLLEHACYTFAEQWLPHVLFENGWDCPEAGELNVWMHHFNLERMTLCHVAREHDMKESLSNVMHSAKEIRHNAVHRNRVEINELAMHLDHAVALCTILGVQEDLAKVKAIRHYANTEIASIQAAKQEAEKKIMQFIKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQ31</accession>
    <name>I1RQ31_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG06165.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T19651</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324800.1">
        <property type="nucleotide sequence ID" value="XM_011326498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQ31"/>
    <dbReference type="FunCoup" id="I1RQ31">
        <property type="interactions" value="1260"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RQ31"/>
    <dbReference type="EnsemblFungi" id="CEF86108">
        <property type="protein sequence ID" value="CEF86108"/>
        <property type="gene ID" value="FGRRES_06165"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06165"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19651"/>
    <dbReference type="eggNOG" id="KOG1490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011784_4_1_1"/>
    <dbReference type="InParanoid" id="I1RQ31"/>
    <dbReference type="OrthoDB" id="415015at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000496">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="10">
        <location>
            <begin position="168"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="380"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="546"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="452"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF86108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="658" mass="75354" checksum="93A0A0453A62D5DF" modified="2012-06-13" version="1">MKTTWKDIPPVPTQQEFLDIVLSRTQRKLPTQIRAGFKISRIRAFYTRKVKFTQETFSEKFGAILESFPRLQDIHPFHKDLLNTLYDADHFRIALGQMSTAKHLIETISRDYVRLLKYGQSLFQCKQLKRAALGRMATLIKRLKDPLMYLDQVRQHLGRLPSIDPNTRTLLICGYPNVGKSSFLKSITRADVDVQPYAFTTKSLFVGHFDYKYLRFQAIDTPGILDHPLEEMNTIEMQSITAIAHLRSAIMYFMDLSEQCGYTVSAQIALFKSIKPLFSNKLVFVVINKIDVTRPEDLEPSVQEELQGILKSGEVELLQLSCNTMEGVQEVKNAACERLIAERVNQKLKAGTNTSGAIGGRLADVMSRIHVAQPMGGQTLETFIPEGIKDRKKYDKEDPERRRTARDEQDENGGAGVFNVDMKADYMLANPEWKYDKIPEIYDGKNVYDFIDPDIEAKLQALEEEEEKLEAEGFYESDEDDEDDEEAEVLRKAELIREKQQLIRNEARMKKRLKNQAIIPRKMMKKPLSEFEDALDQLGVDTTDIADRARERSRGRARSRSRMGTEDPDSMDVDGHTSTPRERMRSISRPASRAPTASRRDDGVPDDVLRSKADRIAKLNQKRMNRMARQGEGDRHTTASITKHLVVGKRGMGKTNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQ87</accession>
    <name>I1RQ87_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">FG06226.1</name>
        <name evidence="15" type="ORF">FGRAMPH1_01T19803</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
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            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
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            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>PH-1</strain>
        </source>
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    <reference evidence="15 17" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1</strain>
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    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
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            <topology evidence="2">Multi-pass membrane protein</topology>
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        <text evidence="12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQK2</accession>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Sordariomycetes</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
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    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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    <dbReference type="STRING" id="229533.I1RQK2"/>
    <dbReference type="EnsemblFungi" id="CEF85816">
        <property type="protein sequence ID" value="CEF85816"/>
        <property type="gene ID" value="FGRRES_06347"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06347"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20089"/>
    <dbReference type="eggNOG" id="ENOG502SK1Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064110_0_0_1"/>
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    <dbReference type="OrthoDB" id="5421757at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF85816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="342" mass="39904" checksum="FC2FBF20E50C4271" modified="2012-06-13" version="1">MAPNKRAGKQKRAHFADKKNEAPPSPFKRPPEALEPFIQSLDEKHVYVTHIDNKPADFKRKIFLVPVGMNVVVVLLFILRMWWIAPWYWQLLMTGFGHENETTWDTVDSTWSQIALEIGKRAGTMLIDFILFIFVWPWPVEFVAGQARGNPCQWRWQVGFREQEIYVRRSREWDQALTDILEDADSKKSLVSYVDNATSPILQEQKTGYLLMNAYWDLDWARMVIAHRLVDKKELALEAFKSVVLVHHDAYGWMSYDVRGSGASGEDERRRQVFAFRDALTKLGKENLFYRWVEIVQFEATQPGGFGPKEQEAAAKRIRELFEKEDIDFDDLWKKSISSLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1RSC0</accession>
    <accession>A0A098DT43</accession>
    <name>I1RSC0_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
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        <name evidence="4" type="primary">FG07034.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T23787</name>
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    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326722.1">
        <property type="nucleotide sequence ID" value="XM_011328420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RSC0"/>
    <dbReference type="STRING" id="229533.I1RSC0"/>
    <dbReference type="EnsemblFungi" id="CEF83998">
        <property type="protein sequence ID" value="CEF83998"/>
        <property type="gene ID" value="FGRRES_07034"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07034"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23787"/>
    <dbReference type="eggNOG" id="ENOG502S4QH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067876_0_0_1"/>
    <dbReference type="InParanoid" id="I1RSC0"/>
    <dbReference type="OrthoDB" id="10255576at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052618">
        <property type="entry name" value="ComplexI_NDUFA12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470">
        <property type="entry name" value="ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF83998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="190" mass="21837" checksum="E6E4A3C57CDD5EAD" modified="2012-06-13" version="1">MSSKQIGPVTRAWYKWKALRLPWRKRFLMGFDLQGNTYWEFRLVRGAESRERWRRIVQYPGSTHLSSVKVSPMWHQWLRHTREEPPTIEEQQDDVVRQARMKTLAAQADARWEAKPRVMEAPQAAPAPLLQPANASPSGQDSKTVQADAGAKNIKDEVEKKDDPWAKAKASAPGETWQPSAWTPPATKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>I1RSD8</accession>
    <accession>A0A098DNJ6</accession>
    <name>I1RSD8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG07055.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T23847</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF82919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326752.1">
        <property type="nucleotide sequence ID" value="XM_011328450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RSD8"/>
    <dbReference type="FunCoup" id="I1RSD8">
        <property type="interactions" value="1201"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RSD8"/>
    <dbReference type="EnsemblFungi" id="CEF82919">
        <property type="protein sequence ID" value="CEF82919"/>
        <property type="gene ID" value="FGRRES_07055"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07055"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23847"/>
    <dbReference type="eggNOG" id="KOG0306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005318_0_1_1"/>
    <dbReference type="InParanoid" id="I1RSD8"/>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001884">
        <property type="entry name" value="WD domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001226">
        <property type="entry name" value="WD repeat-containing protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="844"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="421"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="502"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="601"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="643"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="690"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="9">
        <location>
            <begin position="825"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="749"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF82919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF82919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="960" mass="106941" checksum="6E1AEEFEDDE2A471" modified="2012-06-13" version="1">MVKSYLKYEHGKSFGVVASPTSNLVWSSKDRTGTSAGQAIVAANEEVICWDIKKGELISRWRDERCTVPVTAIAQSKADKDVFAVGYEDGSIRLWDSKISSVILNFNGHKSAITKLVFDKSGVRLASGSRDTDIIMWDLVAEVGQFKLRGHKDQITGLQFVEPEAQVQDEDGSRAMVIDGEGTHEGFLLTTGKDSLIKLWDLSSRHCIETHISQTNGECWALGLSPDYSGCVTAGNDGEIKVWSLDADGLALSTRQVDAPAAAQYLQDKGTLHRQSKDRATEVVFHPKKDYFAVHGSEKAVDVWRLRSEAEIKKALARKRRRRREKAKDGKAAEEEANGEEPEDVSKADISDVFVQHVIVRTGGKVRSVDWAVPSGQKDLQLLVGTTNNLLEYYSVSRKDKSDKSKKEDAPEYTRALSVELPGHRTDIRALSLSSDDKMLASASNGNLKIWNVKTTACIRTFECGYALCCAFLPGDKVVVVGTKSGELQLFDVASAALLDSVDAHEKAIWSLSVHPNGQSVVSGSADQTAKFWDFKIVQEEVLGTRRTTPKLKLVQSRTLKVSHDILSLKFSPDAKLLAVALFDSTVKVFFVDSLKLYLNLYGHKLPVLSMDISYDSKMIVTSSADKNIRIWGLDFGDCHKALYGHKDSILQVAFVPHNNDGNGHHFFSSSKDRTIRYWDGDKFEQIQRMDGHHGEVWAIAVSHSGNLLVSAGHDKSIRIWDETDEQIFLEEEREKEMEELYESTLTTSLERDADAQDENNEVGAASKQTSETLMAGERIAEALEMGMADLNLLKEYEEAKLTNPHAQPPQRNMVFLALGDITAEAYVLSVLQKIKASALHDALLVLPFSSIPILFTFLNIFAMRSMNMPLTCRILFFMLKTHHKQIVASRSMKVMLDGIRINLRASLKRQKDEMGVNIAALKVVGMQIRDKSIKDYVDENWEEENDARSAKKRTFVDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RSI2</accession>
    <name>I1RSI2_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">3'(2'),5'-bisphosphate nucleotidase</fullName>
            <ecNumber evidence="3 10">3.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG07103.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T23967</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="3 10"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326805.1">
        <property type="nucleotide sequence ID" value="XM_011328503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RSI2"/>
    <dbReference type="STRING" id="229533.I1RSI2"/>
    <dbReference type="EnsemblFungi" id="CEF84519">
        <property type="protein sequence ID" value="CEF84519"/>
        <property type="gene ID" value="FGRRES_07103"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07103"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23967"/>
    <dbReference type="eggNOG" id="KOG1528">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033446_1_1_1"/>
    <dbReference type="InParanoid" id="I1RSI2"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043647">
        <property type="term" value="P:inositol phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006239">
        <property type="entry name" value="DPNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01330">
        <property type="entry name" value="bisphos_HAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF2">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF84519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="352" mass="37446" checksum="9D7DB9CFD0CA8F32" modified="2012-06-13" version="1">MASYTRERQIAELAVLRASILTKRVQSTVSGISKADDSPVTAADFAAQAVLISALRKAFPGDAFVGEEDSSALREDDALKQRVWELASNAHLENPDDEALLASPENVDELLEVIDLGGRGQGGKKGRFWVMDPIDGTATFLKGEQYAVSLALVEDGREVVGVLGCANLKPVDGKVAESTIDKDGLGLMLTAVRGQGTTIRKMEFNGLQPAQPLDSIAKASSLADSQIINYSSGSTSRHDLITKLADSFGAKFPNIELYSSHIRYAALLVGGGDFQLRVPSSSSVRMYIWDHAGAQLILTEAGGKVTDLDGKEMDFAAGRDLNQNNGLLAAREGIHGAVLEGMGKILAEDASR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-08-12" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1RV21</accession>
    <name>BUT81_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-oxoglutarate-dependent dioxygenase FG08081</fullName>
            <ecNumber evidence="5">1.14.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Butenolide biosynthesis cluster protein FG08081</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">FG08081</name>
        <name type="ORF">FGRAMPH1_01T09071</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2007" name="Fungal Genet. Biol." volume="44" first="293" last="306">
            <title>A novel gene cluster in Fusarium graminearum contains a gene that contributes to butenolide synthesis.</title>
            <authorList>
                <person name="Harris L.J."/>
                <person name="Alexander N.J."/>
                <person name="Saparno A."/>
                <person name="Blackwell B."/>
                <person name="McCormick S.P."/>
                <person name="Desjardins A.E."/>
                <person name="Robert L.S."/>
                <person name="Tinker N."/>
                <person name="Hattori J."/>
                <person name="Piche C."/>
                <person name="Schernthaner J.P."/>
                <person name="Watson R."/>
                <person name="Ouellet T."/>
            </authorList>
            <dbReference type="PubMed" id="17175185"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2006.11.001"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="2 5">2-oxoglutarate-dependent dioxygenase; part of the gene cluster that mediates the biosynthesis of butenolide, a mycotoxin that shows antibiotic activity but does not seem to play a major role in the spread of head blight in wheat (PubMed:17175185). Butenolide is derived from glutamic acid via a 4-acetamido-2-butenoic acid intermediate (Probable). The predicted function of the NADH:flavin oxidoreductase FG08077, the cytochrome P450 monooxygenase FG08079, the decarboxylase FG08083, and the putative acetyltransferase FG08082 are consistent with this pathway, however, the respective activities of the butelonide biosynthesis cluster enzymes have still to be experimentally determined.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="induction">
        <text evidence="2">Highly expressed under trichothecene-producing conditions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="5"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320741.1">
        <property type="nucleotide sequence ID" value="XM_011322439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RV21"/>
    <dbReference type="SMR" id="I1RV21"/>
    <dbReference type="STRING" id="229533.I1RV21"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T09071">
        <property type="protein sequence ID" value="FGRAMPH1_01T09071-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G09071"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08081"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09071"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_4_0_1"/>
    <dbReference type="InParanoid" id="I1RV21"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0223">Dioxygenase</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000450726" description="2-oxoglutarate-dependent dioxygenase FG08081">
        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="176"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="17175185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="17175185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="17175185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76338"/>
        </source>
    </evidence>
    <sequence length="332" mass="37686" checksum="821149E7CED7763A" modified="2012-06-13" version="1">MTASSRPAEYRDVRTANLNTITFDNLFDKDEAELKRLIESCEKDGFFYLDLKSAASQKFWNDLYTIDSTTKDWFKQPIEKKLQTPTVSLAHGFKAVGNQSGSIESKKDGFEALKIGKSELDGRWALPDVVSDNLPLFDQFASSCHFISKLLLDCLSDGLNLKGDARFETHHRDDCRSKSTLYFLHYPPGAQDPNKVGQNMHTDIGTLTILYAPQWGLQVFSPADGAWEYVEPRPNQIIVNVGDTLRFLSGKRFKSALHRVLPLGGIQIEDRYSISYFLRASDSTEFKDSDEDESNAKQWYTKKYAMYEMPHVIQKQQTTLSGGMAQELQATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RW98</accession>
    <name>I1RW98_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG08559.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T10259</name>
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    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320194.1">
        <property type="nucleotide sequence ID" value="XM_011321892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RW98"/>
    <dbReference type="STRING" id="229533.I1RW98"/>
    <dbReference type="ESTHER" id="gibze-q4i2j9">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF76933">
        <property type="protein sequence ID" value="CEF76933"/>
        <property type="gene ID" value="FGRRES_08559"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08559"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10259"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_1_0_1"/>
    <dbReference type="InParanoid" id="I1RW98"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="109"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF76933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="339" mass="37580" checksum="2953CA8DA2FB39CA" modified="2012-06-13" version="1">MSFPDPELTSYAFKTAPPLDPAWLEHENEVKKRGPPRTFNTVEERQPVYAQECRVLYEQMTAPGARDHDLTQGFVKKEFTVSSSVDGHPIPILQLELEENEGDEPDVIVIFFHGGGLKVGEADSEELSCRHMVKSGVAKLRLYSVGYRLLPQNPANRCLSDCLDAFRALRAPATKTIVAGSSSGGQMASAVAQAVPRGSIHGLLLRCPVTADRASGEDFVPEKLRPYHASVSPTFITSLNGYLNRDVPRDGLEKLPLEATAEDLEEHPRTWIQITSNDTLYSDGLCYGMLLRGAGVEVKMQVEVGWPHTFWLKAPHLDFALECERHMVKGLEWLIDAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1RWS0</accession>
    <name>I1RWS0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG08750.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T10733</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319977.1">
        <property type="nucleotide sequence ID" value="XM_011321675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RWS0"/>
    <dbReference type="EnsemblFungi" id="CEF77169">
        <property type="protein sequence ID" value="CEF77169"/>
        <property type="gene ID" value="FGRRES_08750"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08750"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10733"/>
    <dbReference type="eggNOG" id="ENOG502SD7X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054588_0_0_1"/>
    <dbReference type="InParanoid" id="I1RWS0"/>
    <dbReference type="OrthoDB" id="5378679at2759"/>
    <dbReference type="PHI-base" id="PHI:1592"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF77169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="343" mass="37643" checksum="10BE707EF41849D0" modified="2012-06-13" version="1">MAPRLLLFAGAPPSSSLNSESCTITQIDDSFAEFLGLASQKPSHTPLSTLAPWRSLPLNRKPLHTAFSQTHDASIDLASQSEFFTTADVSFKEQSQSFESDGNGDGETTLSQFYDHSLALHNPIPSSQLDSFQETTFEETSFEGTSFMTTLAAERAGTMEPVPSHLSGLEDIPPAPKILALHPQTVTLNIVAGIISIAQPRTITTRWGRTLSLVEILLGDETKTGFAVTFWLEEANAAAAEISALRRQDVVLMQNVGLHVFQNKVHGQSLRRGMTKVSLLWRRDGAGLYSTKDLSKRGQMHPQLRKAKKVKDWVLRFVGAAAGAKTRTSRARLSWDRPPDDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RX46</accession>
    <name>I1RX46_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG08896.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T11113</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319810.1">
        <property type="nucleotide sequence ID" value="XM_011321508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RX46"/>
    <dbReference type="FunCoup" id="I1RX46">
        <property type="interactions" value="1083"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RX46"/>
    <dbReference type="EnsemblFungi" id="CEF77359">
        <property type="protein sequence ID" value="CEF77359"/>
        <property type="gene ID" value="FGRRES_08896"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08896"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11113"/>
    <dbReference type="eggNOG" id="KOG3301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089738_0_0_1"/>
    <dbReference type="InParanoid" id="I1RX46"/>
    <dbReference type="OrthoDB" id="1697570at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000021">
        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="9">
        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="105"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF77359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="191" mass="21961" checksum="36E616B4D5D5DCF5" modified="2012-06-13" version="1">MPPRAHSKTSRVPRRPFESARLDSELKLVGEYGLRNKREVWRVGLTLSKIRRAARQLLTLDEKDPKRLFEGNALIRRLVRVGVLDESRMKLDYVLALKIEDFLERRLQTCVWKLGLAKSIHHARVLIRQRHIRVGKQIVNVPSFIVRLDSQKHIDFALTSPFGGGRPGRVRRKKAKAAEGGEGGEDEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RXN8</accession>
    <accession>A0A098DPL0</accession>
    <name>I1RXN8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG09112.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T27897</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328677.1">
        <property type="nucleotide sequence ID" value="XM_011330375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RXN8"/>
    <dbReference type="SMR" id="I1RXN8"/>
    <dbReference type="ESTHER" id="gibze-q4i0z6">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF83292">
        <property type="protein sequence ID" value="CEF83292"/>
        <property type="gene ID" value="FGRRES_09112"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09112"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27897"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_3_1"/>
    <dbReference type="InParanoid" id="I1RXN8"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="80"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF83292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="322" mass="35163" checksum="05ED754A54F8ACCC" modified="2012-06-13" version="1">MSSYADSWLKFEEGIGGVRPVLRGTAEEMRTQYNGLGSALASLSSPVSDTQVKVTEGDVSGIKYRIYKPQGETKNFPIGVFYHSGGFVVGNLDAEDSFCRTVALRAGITIVNVDYRLSPEHKAPTHVEDAVALYEWAYHNAESISGDPSKMFTIGTSAGGGLALSTARKIVLGQTTLPMDAIKGVVALCPLTLHYENIPAEHQPQHLSYQEHGENIPIVDKLSLSQMLANTGIRPDDKDYFPILDHSCLKLFPPTYVVTCGQDALRDDGNILSNALSSAGVPTKTNHYESMPHCFWIVPTLPETKEFLDALTGGIQWIKSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RY58</accession>
    <name>I1RY58_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T27443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328468.1">
        <property type="nucleotide sequence ID" value="XM_011330166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RY58"/>
    <dbReference type="FunCoup" id="I1RY58">
        <property type="interactions" value="1132"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RY58"/>
    <dbReference type="KEGG" id="fgr:FGSG_09295"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27443"/>
    <dbReference type="eggNOG" id="KOG0896">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063065_4_0_1"/>
    <dbReference type="InParanoid" id="I1RY58"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="6"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB65475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="140" mass="15678" checksum="99ED0DC0CF9F62DF" modified="2012-06-13" version="1">MSAKVPRNFRLLEELEKGEKGLGAEACSYGLEDPEDLLMSSWNGTILGPPHSVHENRIYSVKMHCGPDYPDLPPTIQFISQVNLPCVNPNNGVVDPSQLPCLAQWKRENTMETVLIELRRYMASSQNKKIPQPPEGSTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RYP6</accession>
    <name>I1RYP6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T26925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328215.1">
        <property type="nucleotide sequence ID" value="XM_011329913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RYP6"/>
    <dbReference type="FunCoup" id="I1RYP6">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RYP6"/>
    <dbReference type="KEGG" id="fgr:FGSG_09504"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26925"/>
    <dbReference type="eggNOG" id="KOG3007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042088_0_1_1"/>
    <dbReference type="InParanoid" id="I1RYP6"/>
    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB65420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="464" mass="51224" checksum="93D7411DA8FD6963" modified="2012-06-13" version="1">MTFTILSNDQVNSILEGLNVDELEEFRHVLASSLHEFSTGIPALEEAFQEPERTSTLHPDTMAETLYMPSCAPCGMGCKVVSSTSPEARQYSDETEQRSPVGVVNLFTSDGTPLGIINATTLTAFRTALASTCLLARRNHVKTLTVFGSGLQAYWHIRLALMMRGKTIKRVHVINHRWSDNATGLLERFANIDPDIKQREGWSDTKFGLLIPAFHEYKRLVKEQIREADVIYCCTTSQKDLFDGSILTSHEGRRKGRLIIAVGSLTPDHRELPEDLIHLAAKRDDKPHRHFHKHAIEGGVIVVDSIRGVLKDAGEIIAANVGPHQMVELGELVMLHRLAIEESDGFASSQTSLTSDMDKMDVHGRSSMSTVFGSGSNTSETLASPMDSVDSEGRRSGSFFHSRKSSSSSLDKEKRKSEDSLCQWLRDGTVVYKSVGLGLMDLVVGTHLIGFANKKNVGTRIDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I1RYX1</accession>
    <name>I1RYX1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG09582.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T26745</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328129.1">
        <property type="nucleotide sequence ID" value="XM_011329827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RYX1"/>
    <dbReference type="EnsemblFungi" id="CEF83967">
        <property type="protein sequence ID" value="CEF83967"/>
        <property type="gene ID" value="FGRRES_09582"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09582"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26745"/>
    <dbReference type="eggNOG" id="KOG4575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016738_0_0_1"/>
    <dbReference type="InParanoid" id="I1RYX1"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052557">
        <property type="entry name" value="CAP/Cytokinesis_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF5">
        <property type="entry name" value="TRANSGLUTAMINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="2">
        <location>
            <begin position="405"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF83967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="676" mass="73418" checksum="220BDEB02AB0B61C" modified="2012-06-13" version="1">MADTEEPQFNTLAERIAALNKQKSFANAQSPSPGPGPVRKRPPPPPPPVRPAIEGRSQTVPVISTTPSPSQNNPALPPRPSRQASTPQLRAQNGQDGAQRVPPPLPSRTPTMPSSAPILPPRRTSTQSSLMVRRNSGSSERSQNSAISTLSTGRPPSSVTSVNSDGASYKVPPAYDPASLPKLPPSRREKEAAAKDVARPNRAPPSPQPPRAIEPTPPARPSLPPRLPSRPAKPQADATPEPQAVTQTRKIPPRPSTNGKSKGPVILGFSNKEKPQDSQPALPARPPIPGRPQPDNEPPPVPLASRPSMAQIEAFETKALTAAGPINGCLICRDWSAPDAIAAQYPRQSLPRNDPIGYLAQVLCSPLPSYTDKARAIFTWFHYNINYDTEAFFNKNIKHMTAEDTVLAGKAVCAGYAETYKAIANRAGLECVVVTGHGKGFGYTPLKRGERPPPAKPDGHAWNAVRIDGGDWKLLDACWGAGHVDGQNYVAKFTPAQFTYANEHFGLRHFPKDSRHQFRADGQPVTWESYYTGGIDGEPPGVCGTTSEEGISEPSIEPKQRHISIDSGEIVRFQYSKICEHWTEEKCGGKERLVLLSLPRGEGERDEMIPLETNGFWYWLDVNARDLGPRGKSVRLIVLTSFDGREDATGVTGKEFLAKVGRCAMGWSYLVEWVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZP0</accession>
    <name>I1RZP0_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="7">HIU hydrolase</shortName>
            <shortName evidence="7">HIUHase</shortName>
            <ecNumber evidence="7">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG09890.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T06773</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="7"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318796.1">
        <property type="nucleotide sequence ID" value="XM_011320494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZP0"/>
    <dbReference type="STRING" id="229533.I1RZP0"/>
    <dbReference type="EnsemblFungi" id="CEF75191">
        <property type="protein sequence ID" value="CEF75191"/>
        <property type="gene ID" value="FGRRES_09890"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09890"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06773"/>
    <dbReference type="eggNOG" id="KOG3006">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115536_0_1_1"/>
    <dbReference type="InParanoid" id="I1RZP0"/>
    <dbReference type="OrthoDB" id="10265230at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023419">
        <property type="entry name" value="Transthyretin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00769">
        <property type="entry name" value="TRANSTHYRETIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF75191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="144" mass="16132" checksum="5C7FC0523F6C4A7F" modified="2012-06-13" version="1">MVSPTKDPITCHVLDTQAGKPARGIRVRLEGPIPPSANPHSAAQPRANTFESITDEDGRVTSWLPFLSEDSAGEPPLQTLVEILEDRKGRGSSRWTLRFDTGAYFGEENTFFPEVTVTFRMEERQTYHVPLLLSPYSYTSYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I1S043</accession>
    <name>I1S043_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG10058.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T07181</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318987.1">
        <property type="nucleotide sequence ID" value="XM_011320685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S043"/>
    <dbReference type="EnsemblFungi" id="CEF75395">
        <property type="protein sequence ID" value="CEF75395"/>
        <property type="gene ID" value="FGRRES_10058"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10058"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07181"/>
    <dbReference type="HOGENOM" id="CLU_180934_0_0_1"/>
    <dbReference type="InParanoid" id="I1S043"/>
    <dbReference type="OrthoDB" id="10281978at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124640" evidence="1">
        <location>
            <begin position="32"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF75395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="100" mass="11031" checksum="94D13261758E5406" modified="2012-06-13" version="1">MHLQGQGTDCLSGLGWAGLLVFASLYRDAACNEWDAGRVPGLAGEGLNGVIEHTGNTGLKNKMTVYVMLSNHEWYLLRIPPRQKGKIEIHDVQKTICHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1S0F1</accession>
    <accession>A0A098D9B2</accession>
    <name>I1S0F1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA methyltransferase 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG10175.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T07459</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319116.1">
        <property type="nucleotide sequence ID" value="XM_011320814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S0F1"/>
    <dbReference type="STRING" id="229533.I1S0F1"/>
    <dbReference type="EnsemblFungi" id="CEF75534">
        <property type="protein sequence ID" value="CEF75534"/>
        <property type="gene ID" value="FGRRES_10175"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10175"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07459"/>
    <dbReference type="eggNOG" id="KOG0838">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_5_2_1"/>
    <dbReference type="InParanoid" id="I1S0F1"/>
    <dbReference type="OrthoDB" id="270651at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18105">
        <property type="entry name" value="SpoU-like_MRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000035">
        <property type="entry name" value="TrmH family RNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047182">
        <property type="entry name" value="MRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047261">
        <property type="entry name" value="MRM1_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103:SF1">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNA 2-O ribose methyltransferase substrate binding" evidence="11">
        <location>
            <begin position="312"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="42"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="194"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="621"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="62"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
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            <begin position="106"/>
            <end position="135"/>
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            <end position="257"/>
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            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="621"/>
            <end position="630"/>
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            <end position="689"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF75534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="695" mass="78879" checksum="2F7F800BE0BD9DDD" modified="2012-06-13" version="1">MIYPAQLRASALSQPLSRLHIAQKSFAPVFVRGKGLSAIHRGIRREVGRTEPGAPNPSSFDRPPRSPRRETSYNRREAPPARRDPFADKFSARAVDRGAQSNTRNWRQEQNLRKKLRKKDEEKAAQEEREADGTARRTRRKRFADPENEFGSRSLVHRMKYGDLKEVADKLRVKQPIQPRSFRQAARDRALEFGELDGTSRHERRPERSQQQSDHPEQKFERSDRRPDRPQQQFDRPDRQFDRSDRRPDRWSDKPPQRFDNSNRSAPRRDNTRNDRWNSPDEDSSDVYAVERAQRNGMMAMTIKYTTAASQFLYGRSVVKAALEQNRRKLYNLYIYGGENRMDNKDNTIMTRMAEKHGVPITTVPTHEQRIMDKMSMGRPHNGFVLEASPLPQLPIKSLGKLEESPGRLGFHVDLDYQTREEAAVNGTDTFTRRSNDVTPKPFVLLLNEIMDPGNLGGIIRTASYLGVDAVCITNRGSSTLTPVVLKSAVGAVEEISLFTVDDPVKFVEESGKAGWKTYAAVAPPDRKLVRRHGDKFISLDSIESTSPLNDHPCLLVLGNEGHGLSKPVKVASDYELSVPRFVQGSCVDSLNVSVAAGLLCHAFVKEPVVEVKYEKIEKTEQEPEVKAVEPVEEETVTATTVETETQPAEEAQTESVTIAEQSETITEETEVATKEEETNSEEKEKVEESNEQMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1S1L2</accession>
    <accession>A0A098DAU9</accession>
    <name>I1S1L2_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG10619.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T08543</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF76074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319624.1">
        <property type="nucleotide sequence ID" value="XM_011321322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S1L2"/>
    <dbReference type="STRING" id="229533.I1S1L2"/>
    <dbReference type="EnsemblFungi" id="CEF76074">
        <property type="protein sequence ID" value="CEF76074"/>
        <property type="gene ID" value="FGRRES_10619"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10619"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08543"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013022_1_0_1"/>
    <dbReference type="InParanoid" id="I1S1L2"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF13">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="617"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="651"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="690"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="710"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF76074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="720" mass="80344" checksum="6AE723AB54B44E3E" modified="2012-06-13" version="1">MASLHAGTARSILIGKQKDQVHAHSKLIHHGKTSSNGSDISETELPAPPLPAYIVDEASSSSSHPPSLRSSWGPESVGTPDTNTPAPASVSGSAATKPHDLIVPGARLPLSFSNCGSSNASEAGRPSTPSADSDITPVQQPFARQHDDAAHEFKNNGADAAKPKVDVSAEDDVDQAVLMKRGRRKVTTQKYVLTAGLIAVKYYYIYLPFISFPLVLNCAMIASIAFFSLAHYIRPEKQIKPETPENLVYVIPCYNETYEECTRSLDSLVNQTGLEGHKKGIMVICDGRVRGPGMSKTTGDYLNEDIFKHQTQRKKIRGAYTAWDGQQMDIEISKGFYKGTPFYCIVKDQNQGKRDSLIVIRSFLYKFNTRAQNPESIFSRDFLDSMTSWLEDEVKMENVDHLVGMDADTVFEDQCISELLKESYYPNTVGVCGYVAVDYKDSNWNLWSLYQSAEYTIAQGLRRLHQSIATKKVSCLPGCCQLLKICDETCGDLVLVDLFGYFPKHMDGMIKRIRATASEDRNHICQLLVTFPHAQTRQALFARAYTDVPHSWNVFLSQRRRWTLGATSNDLLLFTAWNTQWWERIVAFSNVLTWSLNIFVIASIGCMIVAFMSQPVWLIMCFAGVMIIPLLYYIIMVTWLPRNLVERGQFLLGLAIFVFLGPFLNIAVMIYAVTNMDNFGWGKTRKVVTDDSEETSHNEGVVSRDNSSVEVKEKATAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1S276</accession>
    <name>I1S276_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">General transcription and DNA repair factor IIH subunit TFB4</fullName>
            <shortName evidence="14">TFIIH subunit TFB4</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">RNA polymerase II transcription factor B subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">FG10862.1</name>
        <name evidence="16" type="ORF">FGRAMPH1_01T20653</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the TFB4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325527.1">
        <property type="nucleotide sequence ID" value="XM_011327225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S276"/>
    <dbReference type="FunCoup" id="I1S276">
        <property type="interactions" value="1178"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1S276"/>
    <dbReference type="EnsemblFungi" id="CEF86281">
        <property type="protein sequence ID" value="CEF86281"/>
        <property type="gene ID" value="FGRRES_10862"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10862"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20653"/>
    <dbReference type="eggNOG" id="KOG2487">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040211_0_0_1"/>
    <dbReference type="InParanoid" id="I1S276"/>
    <dbReference type="OrthoDB" id="17307at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="326"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CEF86281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="355" mass="38039" checksum="6015026F204AAED6" modified="2012-06-13" version="1">MDAVDVSEHYEVSTREDTPSLLSIVLDTNPRAWASLNSLLPLSRAIANILVFVNAHLAFSNANRVALIAAHVDRAEWLYPTPPKPSRDASGDVEMNDASQTQTSANKFPEFAQIETAVLSGIRKLMDQTKEADLSATTTQISGALTLALCHINKAAQALCSPTANLEDSHKGSSSTSPPTVRGRILVISVSDSEPSQYIPTMNAVFAAAHTQVAIDTLSLTGEPTFLEQACYNTGGTYLAATHPQGLLNYLMFGLMSDTEAREALINSVHDTVDFRAACFCHGRVVDTGFVCSICLSIFCETPENSECFTCGTKLSLGNYGAKPAVVPRKKKKKRKVVNGGSREETGSATGTPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I1S2P3</accession>
    <accession>A0A098DW42</accession>
    <name>I1S2P3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG11043.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T21099</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325316.1">
        <property type="nucleotide sequence ID" value="XM_011327014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S2P3"/>
    <dbReference type="STRING" id="229533.I1S2P3"/>
    <dbReference type="EnsemblFungi" id="CEF86046">
        <property type="protein sequence ID" value="CEF86046"/>
        <property type="gene ID" value="FGRRES_11043"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11043"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21099"/>
    <dbReference type="eggNOG" id="ENOG502T1M9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037438_1_0_1"/>
    <dbReference type="InParanoid" id="I1S2P3"/>
    <dbReference type="OrthoDB" id="4358152at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF86046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="382" mass="42856" checksum="B56F027724E210B1" modified="2012-06-13" version="1">MSLVICDTANAGRTSLEWILTEILEIIASNVPSLDTLWNLLRASPRCWRIFTLRYAHITESALSGSNSITPLLVRELIRAVALVRAQNFPFPSLDILRWDFMTAIARNTNRDEYARCGDTTGITFGPNSLPDSRDVITSVVATANHISVSAQSVLASCIKRLKRSNLNCLPPDPDPEPRPPYLSGVIEAMGQPTYLEEMRAVRALWIIQLTGEVRAMVKSRPDVVRWTEDEVSRLSQKNPATILPYAAYHHVAVEVRTMMYYLPACYKNDTVFRLPQAPAPSECNRWATMPSDSQSYDEWCLGNESYGGDLLSCGNSTVSDRLPRLGFAFWEFATMYRLGLARRLPGLTLTTHYRHLVLQGICENTFLTVKTQSGDCSRAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1S382</accession>
    <accession>A0A098E392</accession>
    <name>I1S382_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG11252.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T21611</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325999.1">
        <property type="nucleotide sequence ID" value="XM_011327697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S382"/>
    <dbReference type="STRING" id="229533.I1S382"/>
    <dbReference type="EnsemblFungi" id="CEF88576">
        <property type="protein sequence ID" value="CEF88576"/>
        <property type="gene ID" value="FGRRES_11252"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11252"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21611"/>
    <dbReference type="eggNOG" id="ENOG502SJQV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021598_0_0_1"/>
    <dbReference type="InParanoid" id="I1S382"/>
    <dbReference type="OrthoDB" id="5422579at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124770" evidence="1">
        <location>
            <begin position="20"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF88576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="510" mass="58882" checksum="8D523A2A39740533" modified="2012-06-13" version="1">MASFLLLLLPAELQNAIYASLGVNDIKNLRVTCSALAKALPLHFDRVFISANSLNIEVFNAIANHETFRHQVTEIIWDDARFRTEPKLGEEEQDYWGYESDTEYECTRWFRRGRFDYGDQGTYIYPGVHMGITESWEHYQALMDDQTQVLSCNADIEAFNHGLRRFTSLKRVTITPSAHGRHWSPLYRTPMIRAFPVGFDYPLPRTWQFYDDDEPFDALPWVSHGDETPHLDICGVESTAEVYRDQWRGFRLVTRALSEYADHTISEFVIGGTEVQSGLNCRIFDQWSPEYGDLVTLLKRPGFRHLELHLFTAFLEDDDWHSLKTGLLRDAFAQAKDLEYLCLRTTTDISDGVPQCLIPGIEGHAVPLRGIFLPESWSRLQHFVITNLLVELDDFMSLLASLSPSLRSVKIIDMAFESQEHGYDDLLRAIRDDLDWRLRPVGERPKVQIAAKRLDDDEIEEGRYIIFGQPISSYLYGTGKNPFEDSKYRIRQGRGAVQRDIFDPGFEEPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>I1S384</accession>
    <name>I1S384_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-L-fucosidase</fullName>
            <ecNumber evidence="3">3.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG11254.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T21615</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325997.1">
        <property type="nucleotide sequence ID" value="XM_011327695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S384"/>
    <dbReference type="SMR" id="I1S384"/>
    <dbReference type="EnsemblFungi" id="CEF87037">
        <property type="protein sequence ID" value="CEF87037"/>
        <property type="gene ID" value="FGRRES_11254"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11254"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21615"/>
    <dbReference type="eggNOG" id="KOG3340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002934_6_0_1"/>
    <dbReference type="InParanoid" id="I1S384"/>
    <dbReference type="OrthoDB" id="6039950at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031919">
        <property type="entry name" value="Fucosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF37">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16757">
        <property type="entry name" value="Fucosidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124756" description="alpha-L-fucosidase" evidence="7">
        <location>
            <begin position="26"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="8">
        <location>
            <begin position="22"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-fucosidase C-terminal" evidence="9">
        <location>
            <begin position="426"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF87037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="609" mass="68003" checksum="1E1F466184961825" modified="2012-06-13" version="1">MITLPPKATALVALACALFPAATTAKADGPYEATWESTDKHNAAPEWYRDAKFGVYWHWGAFTTAQYASEWYPRNMYEPDSDQRKHHTETYGPPEEWGYENFIKGAKDKKGNFVQFKPVLKSKGGEFDPEAIIKIVKGSGARFAGPVAEHHDGFSMWDSKVNEWNPVNYGPKLDLVKLWADLVRENDMKLVIAMHQAYNYNGFFQWAPKTNDTSLQKLLGQLPRDEEDQLWFDKHREMLDHVQPDIIWNDFSLDSPGECGSFEGPCAVDEQKRLEFLAYYFNRGEEWGKEVVTTYKHHDHGFRNTSAVDDWERGGPSNLVRPYWQTDDAISASSWSYTVGIKYYSSKAMVHSLLDRVSKNGNMLLNISPMANGVLPEEQIKVLNDIGDFLSRYGEAVYDTRAWDIYGEGPNQVEGGSFTAPLQGNSSDIRFTRNKEDDVLYVTVLGWPEDNLVSVKNLGSNALVDLESLKSVELLGDKAGDYVKVSEWEQSKDALDITLPSQPAESLAYVLKLTFDGGIPVPQPERGAAVFSKADATGKGVALALGTFDTVFLTEAGLKPEEIRSIRVSDGTKATLFSGFRFTGESKELSAGEHEVEDGSVGSIVVSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1S3W5</accession>
    <name>I1S3W5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG11515.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T16051</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323112.1">
        <property type="nucleotide sequence ID" value="XM_011324810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S3W5"/>
    <dbReference type="EnsemblFungi" id="CEF79825">
        <property type="protein sequence ID" value="CEF79825"/>
        <property type="gene ID" value="FGRRES_11515"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11515"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16051"/>
    <dbReference type="HOGENOM" id="CLU_1562992_0_0_1"/>
    <dbReference type="InParanoid" id="I1S3W5"/>
    <dbReference type="OrthoDB" id="5056362at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF79825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="171" mass="19534" checksum="51F97F968F1366B6" modified="2012-06-13" version="1">MDWSELVLVFPHNFVLVDVLQQHTSYPLTTAIVHFSTDPNIYTNIALHPPLSNSQAPNSKLSSVLNNLDLTERKYNDIAARIPISPQTKRLMTKQCITNNSELVPDLKAHFVGLDINDPPEPTNQSLERKVLADQQALDVATKKYREAAEAFHFWDTEIWKRERSAEVEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1S4E0</accession>
    <accession>A0A098CZR2</accession>
    <name>I1S4E0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T00547</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315822.1">
        <property type="nucleotide sequence ID" value="XM_011317520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S4E0"/>
    <dbReference type="STRING" id="229533.I1S4E0"/>
    <dbReference type="EnsemblFungi" id="CEF72074">
        <property type="protein sequence ID" value="CEF72074"/>
        <property type="gene ID" value="FGRRES_11707"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11707"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00547"/>
    <dbReference type="eggNOG" id="ENOG502SAKB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061825_1_2_1"/>
    <dbReference type="InParanoid" id="I1S4E0"/>
    <dbReference type="OrthoDB" id="5223589at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF2">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF72074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="257" mass="27917" checksum="1671D4F6E6D69408" modified="2012-06-13" version="1">MQFIKDRCRFMHPKLPSYIRHYLSASLKVDFLLEVQLLLLTFSTGIQDAVSYPDFKCFASNQTGNSVVLAVGLAGHDSSVFNLANVGLSLGMFLAGAIMTGQLANFVGPRGRMWLIISHLIQTLLTFVAAIIHPRHAQSGNSPSSMGSLALLAFASGAQVASMRPFRIQEITTAMATAAWVDLVIDPRLLKIQNRSRNRRAGFLISLVLGSFAGAFMRKGVGSSNALYIAAAGKTLVVLMLFLNREEKTKDHSQTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I1S611</accession>
    <name>I1S611_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FGRAMPH1_01T14883</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321351.1">
        <property type="nucleotide sequence ID" value="XM_011323049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S611"/>
    <dbReference type="EnsemblFungi" id="CEF79243">
        <property type="protein sequence ID" value="CEF79243"/>
        <property type="gene ID" value="FGRRES_12282"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12282"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14883"/>
    <dbReference type="eggNOG" id="ENOG502SHZM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1102819_0_0_1"/>
    <dbReference type="InParanoid" id="I1S611"/>
    <dbReference type="OrthoDB" id="441210at2759"/>
    <dbReference type="PHI-base" id="PHI:1855"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF79243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="253" mass="28043" checksum="C98915CD7DE33090" modified="2012-06-13" version="1">MSPSSTKVASGGSFHTFQGIIPKKQPAASSNARPRVAGTRRITTPHACTECKRRKIRCDGKLPCGQCITSRAPKNCSYDKHRQRMIPSRKALDSLAQSLEECRSVLRRLYPNHDVSALRSLDKQELINLLAQSQCSLSDPLPSPPLESSFPKSGTPMMGSDSLLELQTSLEADLDSLIGELEFEVPGEQREASEEANYLAQQSWWDFGSRQWSSVSSVPPMMDGPSYGHDMMTPGQHSMYEDSRGMYGSLEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I1S687</accession>
    <accession>A0A098DIJ8</accession>
    <name>I1S687_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Quinate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG03876.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T13933</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321796.1">
        <property type="nucleotide sequence ID" value="XM_011323494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S687"/>
    <dbReference type="EnsemblFungi" id="CEF78769">
        <property type="protein sequence ID" value="CEF78769"/>
        <property type="gene ID" value="FGRRES_12358"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12358"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13933"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="InParanoid" id="I1S687"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="29"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF78769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="538" mass="59417" checksum="396BB28F3784637A" modified="2012-06-13" version="1">MVKNIFARPKDDSANPAPPEVYNWRIYALAASAALGSSMFGYDSAFIGGTLSLPSFQERFNLASETGTALASLKANIVSTFQGGCFFGVLLCYYMTEKLGRRWVLILCGIIFNLGAIIQLVADGKLSFIYAGRVLTGLAVGASSMIIPVYISESGPPAIRGRLIGIFEIFLQFSQIIGFWVNYGVNIHISPTSDVQWHIPFGLQLAPGTLLVICMLFQPESPRWLLNAGRTDQARKVLQRLRQLPADHAYLNWEIDTVLKQIEEEKSMGADRSFFAKLREVVGPTNRPRLLLGIALMFIQNMSGINALNYYSPSIFKSIGFTGTSVGLLATGIFGIVKASATGLYMIWGVDALGRRQSLMIGSTGAAIALFYLGIYSKLSGSFDVGMVPAEKTPGAYVAIVMVYIFAVFYAISWNGIPWIFCAEIFPMAIRSICLVFTTCAQWLGQFIIVYSTPYMMTDITYGTFLLFACSVVFGLFFAFFLVPETKGISLEDMDVLFSRKGMPRTWRRQTNDVIAQRRAGEEVYSKQGESVVHEEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I1S8J0</accession>
    <accession>A0A098DWQ0</accession>
    <name>I1S8J0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T25173</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327377.1">
        <property type="nucleotide sequence ID" value="XM_011329075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S8J0"/>
    <dbReference type="EnsemblFungi" id="CEF85308">
        <property type="protein sequence ID" value="CEF85308"/>
        <property type="gene ID" value="FGRRES_13168"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13168"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25173"/>
    <dbReference type="HOGENOM" id="CLU_1586629_0_0_1"/>
    <dbReference type="InParanoid" id="I1S8J0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF85308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="168" mass="18498" checksum="6E980B27C1816603" modified="2012-06-13" version="1">MASGKPEPSVIRTMNIAAGIIKSSPLDVTRLRSGQNVSNELKTKRLVDLFASWRYCLSPFFSYLTPVAASLQHYAKLPDSILGIEMYTAANIRPVSKVNASSTESIFISRVLSIGLSSLIAKMYSLMRHEETLHRGSAAESFTVPLPSFLWAIGFIVYVESLEFGIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I1S8T2</accession>
    <accession>A0A098DG54</accession>
    <name>I1S8T2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T11279</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319736.1">
        <property type="nucleotide sequence ID" value="XM_011321434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S8T2"/>
    <dbReference type="EnsemblFungi" id="CEF77442">
        <property type="protein sequence ID" value="CEF77442"/>
        <property type="gene ID" value="FGRRES_13260"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13260"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11279"/>
    <dbReference type="eggNOG" id="ENOG502RR6U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1713438_0_0_1"/>
    <dbReference type="InParanoid" id="I1S8T2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF77442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="153" mass="17449" checksum="E329725552570E1B" modified="2012-06-13" version="1">MAYLTTLEARLDAVYSALETLGPDSLAEDFVNFASFFSEDCIAYLRGMRDHKTPAFGRQGLIHDLQNLLQSQHLKKRRVISQVANEQGGQIFSEMENQYIVHSEILDPFHKTAVVSFNREGLIHSFKLYCCRSHFVWLTQQATGEGSYKDLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I1S8T8</accession>
    <name>I1S8T8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T11197</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319774.1">
        <property type="nucleotide sequence ID" value="XM_011321472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S8T8"/>
    <dbReference type="EnsemblFungi" id="CEF77401">
        <property type="protein sequence ID" value="CEF77401"/>
        <property type="gene ID" value="FGRRES_13266"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13266"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11197"/>
    <dbReference type="HOGENOM" id="CLU_2097094_0_0_1"/>
    <dbReference type="InParanoid" id="I1S8T8"/>
    <dbReference type="OrthoDB" id="10269592at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF77401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="116" mass="12993" checksum="73CBBD4EA0C1F276" modified="2012-06-13" version="1">MSKSQDLIRPFWSPNNVVKLSMTCLTGIGYDVLGEIETTSSYQCPPPSSYLCLNVPTPAGFGRRLPDWTHRRAPYRLIVCPSTAVRYHRPCNSRFLVQGQGAGTDYRAKTPLPSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>V6RZD4</accession>
    <accession>A0A098DB44</accession>
    <name>V6RZD4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG10673.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T08671</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF76138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319682.1">
        <property type="nucleotide sequence ID" value="XM_011321380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6RZD4"/>
    <dbReference type="STRING" id="229533.V6RZD4"/>
    <dbReference type="EnsemblFungi" id="CEF76138">
        <property type="protein sequence ID" value="CEF76138"/>
        <property type="gene ID" value="FGRRES_10673"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10673"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08671"/>
    <dbReference type="eggNOG" id="KOG2451">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_5_3_1"/>
    <dbReference type="InParanoid" id="V6RZD4"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF7">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="28"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF76138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="499" mass="54088" checksum="68DE698C347065BE" modified="2014-02-19" version="1">MANPFQRPFQLENESLFHCTSLINGDFVSAKEGKTFNVVDPGSGKTWASCPDCTASDVDSAVASSYETFKTYSKTTPRFRAQTLMKWHNLILAAREDLARILVHETGKTLVEARGEIDYALTFVWWFSGEADRAHGTSMSCAIPGRRAVTIKQPIGVAAALVPWNFPIALALRKAAAALAAGCTMVVKPSPETPLTCVSIAHLALEAGFPRGALNVVTTSLENTPTVAEALCLDARVKKVSFTGSTRVGKIIASFCAPNLKKTTFELGGNCPFIVFDDADVGQAVSQLMPLKWRHAGQACITSNRVFVHSSIYDTFVEKVVQETRGLKLGHGMEEGSTMGALTTPRGLDKAEELYQDAISKGAKTVLGTGKREEGQGYFMAPTILTEMEDDMLMTHEEIFAPVLGFYRFESEEEVVQRANDTPLGLASYIFTKNVDRLWRLFENLDAGMIGLNAGNSSSAEAPFGGIKDSGHGKESGKDVAIDEFLITKTATLTIDGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098CZU8</accession>
    <accession>A0A0E0RLJ9</accession>
    <name>A0A098CZU8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T00645</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098CZU8"/>
    <dbReference type="EnsemblFungi" id="CEF72124">
        <property type="protein sequence ID" value="CEF72124"/>
        <property type="gene ID" value="FGRRES_15714_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00645"/>
    <dbReference type="eggNOG" id="ENOG502RA4W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098CZU8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF195">
        <property type="entry name" value="ACID PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF72124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="513" mass="58030" checksum="EECA87BDAF7EE1E3" modified="2015-01-07" version="1">MSLAWFRCRARLLALVAVFLFGTFFCLTQYADMGSLRQGSLLALLSSTPALIGSDPKLKWYPPSENKVNSLKGAIDGEGTYGFIFDSSVTPDEKYGTYNWCNMPHARKREYKKPEKEYELQYVEVIQRHHKRTPYAANAFPVESYQWNCDNQGLYYFGRQFTDEPKPNAQGYWKGFISDINPFIPSGWIGSCQFPQITAEGLDDSWVHGKDLYEVYHDLLKFIPGRGEDWRSRVKFRVTNNQITSQVAGMFINGMYQTTDSVPLHIQQAGVDSLEPQYKCSVGSKLTSAIKSSSNAEWKKHLDKTKSLYKILDDISGVPADDEGFHESFDHYYDNLSARQCHAKPFPCKLVDGKNSTTCVDQKLANTVYRLGQWEYSQIYRDAPASLAASATSWGVWIAELASHFRQVMAGKQDILYLHNFAHDGSISRLLSILQIDVMVWPGMGSEVVFELYKKGGKYFVRILFSGKTLKSSHPDLGVMEMVPVERLLEYFDGLAGKDASLVKGRCSGEISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D3D5</accession>
    <accession>A0A0E0RNX0</accession>
    <name>A0A098D3D5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T02289</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D3D5"/>
    <dbReference type="EnsemblFungi" id="CEF72945">
        <property type="protein sequence ID" value="CEF72945"/>
        <property type="gene ID" value="FGRRES_15098"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02289"/>
    <dbReference type="InParanoid" id="A0A098D3D5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF72945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="80" mass="9497" checksum="2F889843E66A4072" modified="2015-01-07" version="1">MLHARQCETCVHMKLAQSLSVRYQEWNSFPLSRYWVGGELWKAISNLLCIEIRQVKEPEKRRGDNKREGFENWGGSKETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D7L3</accession>
    <accession>A0A0E0RRR6</accession>
    <name>A0A098D7L3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG01756.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T04269</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D7L3"/>
    <dbReference type="EnsemblFungi" id="CEF73941">
        <property type="protein sequence ID" value="CEF73941"/>
        <property type="gene ID" value="FGRRES_01756_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04269"/>
    <dbReference type="InParanoid" id="A0A098D7L3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025363">
        <property type="entry name" value="DUF4267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14087">
        <property type="entry name" value="DUF4267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF73941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="150" mass="16629" checksum="728DEC8F987A28DD" modified="2015-01-07" version="1">MSHPILFNGSLGLGLFLSSLGLNASFRPNSHLKALEFPIPKDPEAKKFSRALMRIWGIRNISVGLLIALIWSTGDETLMAKALSLTIALPVTDGFVSRILIGGVQYRQSLKAIIEGISRWFTDIEVWNRSYNYQGLDTNLQLRSIIADIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-06-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DE85</accession>
    <accession>A0A0E0S1A3</accession>
    <name>A0A098DE85_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T10951</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DE85"/>
    <dbReference type="EnsemblFungi" id="CEF77278">
        <property type="protein sequence ID" value="CEF77278"/>
        <property type="gene ID" value="FGRRES_20147"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10951"/>
    <dbReference type="InParanoid" id="A0A098DE85"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF77278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="106" mass="11858" checksum="C0454196C4CC5F95" modified="2015-01-07" version="1">MTKQYRYLIAAQDLKDGVHKEITMGGITRSRVPINNSEVRKPASRLDNGKSCLIHRPSKLVARKLSLILKTILLVFKLVIGPPLKSCDCHESLPLPAVSHFTLRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2024-01-24" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DF45</accession>
    <accession>A0A0E0S0P2</accession>
    <name>A0A098DF45_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG08671.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T10529</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DF45"/>
    <dbReference type="EnsemblFungi" id="CEF77067">
        <property type="protein sequence ID" value="CEF77067"/>
        <property type="gene ID" value="FGRRES_13322"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10529"/>
    <dbReference type="eggNOG" id="ENOG502QSI3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DF45"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19495">
        <property type="entry name" value="Elp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09807">
        <property type="entry name" value="ELP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF77067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="267" mass="28399" checksum="6F945E97448C4A92" modified="2015-01-07" version="1">MASVSRIPHILEPYLALPSEGSLNLVTSVLGASSNWLLLRHVYSYLRGSTDGDESTKDTGVVLVSFMRDGAFWREGSTKLGLDLDAHSRTGRFTFVDGLTGTYGDSKPQTPGARKERVLRGTNLADIKKEIEGAIGDLKASRKVLIIDQLDALLAITDESTTSLTLQNLVLGLRSLVHSTLLTLSADTPLVAAQATTLEREHASLVLSTAHVADAVLALRMLDTGTARDVSGVVRITGPGIEGMGGAAEYLYHVVADGGVKVFERGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2024-03-27" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DH11</accession>
    <accession>A0A0E0S3Y8</accession>
    <name>A0A098DH11_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG03411.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T12821</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DH11"/>
    <dbReference type="EnsemblFungi" id="CEF78213">
        <property type="protein sequence ID" value="CEF78213"/>
        <property type="gene ID" value="FGRRES_03411_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12821"/>
    <dbReference type="eggNOG" id="ENOG502SPBH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DH11"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF78213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="291" mass="31895" checksum="6F7190237052E482" modified="2015-01-07" version="1">MSSENDFEYPWEIKSEVERLQKQYAWVQRCIDNKIIFAPVPLEQEGLRVLDVGCADGTLLRDLRKQVSPSAQLVGIDVVETFLPPSKEGLRYEGYDLCEPPRQELTGAFDVTHVRFVIPGASKVGYQKTVEHLASTLAPGGWLQVHEMDLDVQDKPNVGPAFKEVCALFLGVFKAMGMVPDLINKLPGAFGIAGLRHVSTETVELPMGKLLGDEEAAEMSLRPFLLTIPSLIQGAKGKQPSSSVAIFLTQLGLGADVPESVFDGLAARFEKEVREQGAVFFTKVVLGQKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DL34</accession>
    <accession>A0A0E0S838</accession>
    <name>A0A098DL34_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T15727</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A098DL34"/>
    <dbReference type="EnsemblFungi" id="CEF79663">
        <property type="protein sequence ID" value="CEF79663"/>
        <property type="gene ID" value="FGRRES_15258"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15727"/>
    <dbReference type="InParanoid" id="A0A098DL34"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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    </evidence>
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    </evidence>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF79541">
        <property type="protein sequence ID" value="CEF79541"/>
        <property type="gene ID" value="FGRRES_16103"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15479"/>
    <dbReference type="eggNOG" id="ENOG502SUW1">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A098DNL4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
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        </source>
    </evidence>
    <sequence length="1342" mass="150730" checksum="C54C9EC251EC1AD9" modified="2015-01-07" version="1">MSQSGIIIQKGNVGINQAIHNGDNVIYNAGAEMRKKHIAQKTHNANKIEWEKSETCEWLMDEEDFQNWSNIKTSSPVLWLYGRPGCGKTVLMSRIIESVHSKYTNKVQLLYFYVGNSHNENSDQMYREMLRTFWDQASEKQDIDIWADDSPIEPLEDVVQKLLKDSTVVRYIVIDALDQLPSRFQERLLGWLKATMQKCNLGLAISCRNSHQVRQLQAKETFGIEITTDRNKDDINKYLETSLHSEFLHRNPELRKNIIDKLNAKADGMFLWVRLQALNICNMRTKSQINMALGSLIPPQDINKMFEAYADGFEMESDDPFQQQVCQRLMALLAHSTAPMPKSTVFTALSLKDDGDIDDDHYQDLADNFKLIPSFCKHLVEINEDLDVFQFCHKTVVDFFRKYKPTIYHRRIATLCLSYLSSSKFSGGAQKKVTWYDQGTLESILQKHEFLAFSSSHWFLSLKKSIDNKNDAENETVFNLFKILFNKDGKAEERGNLQLAFQVHLITQGKAIPDGISHEHIVGYFALVSFFDIFNEKAWFDADKPDSKGMRPIHWAIRNDIDQADVTDFVNKMERSGADINIQDHSGCTPLYYAAHCGNAEVVRLLIDLKADLDVTNKHNETALVAACKKRHEDVVLNLVKAQADVHIQSEFGTALQAVSLVGSKICAEKILERYGKSRIRETCGPFGTSLHAAAFHGHADLVKLLCTHRIDVNASDRTYGTPLTAAASGLNPGQEPSLFLEISRELIKRGVKVNDRSGRLGPALRSAAYHGNPDLVQLLLEEGAKVSKSKGMMGTAYEAAKSRGHETVMEMLLKADPDAEKYGENDIAAAHDRQKIQRRIFRATVKASSVNATSNLIREFENFFHKEIPKGETTFLKGLSKLGENCFNDVVTLTTSSTEQPDRESGLLSKRNSMCGLGFLNCFEGEKTPQPESEHNGRSHFVLRRATKTFAADGVGEHFPQVLDRMTQAAVKILEDAIQNGNKDVIRLIANTWVEALNNLVLRPGYGENMLKTVVQRRANELKGYLSDDTLSTEEKWEKAKALALVGIELLVVAVGRGDKFKRLSFVNSKLWVQAVIDVDSLGKDGTSATQQLIGVFAKRFLSAVDTKDVAEAEVCGQGGIELLRAAALSRNKSVLNKFSSEWIRCWGLALRDMKYVSKQMVQQRVGEYCECFMSNKNDGASGLAFAAFELLRTAIEQQESRAASVLCTSIQQGLQWTRTNITTHSYEDHDMQSIFDVFVNLFAIADRGPTVKLEALVLEVLDLAAVAFKDPYQVIKSAVTKRVGHVEEIEDIRKRKGQLAQLNKALRYCLQVASDTAERGQKHAVGLSSIIKEAGLEEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DS22</accession>
    <accession>A0A0E0SDZ3</accession>
    <name>A0A098DS22_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T27803</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DS22"/>
    <dbReference type="STRING" id="229533.A0A098DS22"/>
    <dbReference type="EnsemblFungi" id="CEF84656">
        <property type="protein sequence ID" value="CEF84656"/>
        <property type="gene ID" value="FGRRES_09153_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27803"/>
    <dbReference type="eggNOG" id="ENOG502RMR4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DS22"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF84656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="564" mass="64069" checksum="64D780129CAE1FEF" modified="2015-01-07" version="1">MTQELPDHSLTSVVSDTKPPSDTSTNLDPSAERSNTADLQDNTLCSRCKRNTAQTPDDQSGTNECSSSLEHSSQQLGDRTDQDTGSEVQSVRSMTGSESYSDGSDFHFEREPHWSEIVGPGRLSPRVEGKFLQLIKKKMLFLWGVGTEDVPNISIDTHGLKTLRFKMDNHAVISLAWDEHSRAPTYRKEVTRAQSSICQAWPQDRNVFGVEQFVIASNGRDQATVISLKYIEQSYMDEVVASKNLDILHAGYEDIWHRWCFGADEVLAIKKSPIPLRGKTVYCTSSSQSKGFRHFPLTAFAVAVSDNEPFSVADQERYNFKLSLSYFSANFRGGCVLSDFDDRERIEDLMFDKSFNRSRDYFVALQLLRIMDEWINEAVSSIQQLREDTKFMHPGFSTFEIKDNLDAVDRYMKEKADPVQKRLQKKKEEINSLRDGLFNATSLRESTKAMALNQAIYVFTVVTVLFTPVSFLATFWALPFLNNPREGSVIVPEPSAFRNSFIVMPLLTYAFVLGIAWHVGRENPNATLTRLVSDTWSVLQRWPGSIWELRPRLPERKRTTSSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DSA5</accession>
    <accession>A0A0E0SCT4</accession>
    <name>A0A098DSA5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG06456.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T22319</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
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        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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    <dbReference type="EnsemblFungi" id="CEF84247">
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        <property type="gene ID" value="FGRRES_17682"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22319"/>
    <dbReference type="eggNOG" id="ENOG502SI3E">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A098DSA5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0003677">
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008270">
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
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        <property type="entry name" value="XnlR_reg_dom"/>
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            <begin position="129"/>
            <end position="296"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF84247.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF84247"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="793" mass="89067" checksum="CD73F04CEF49027E" modified="2015-01-07" version="1">MPTTIEEHHGAPANSKSKRQETRRRSPNIRKHVGKHHASDAETETATKTPTAPKEHEDLPAVLTDEFLETPNLADEKPRQTGQPEITFAYYPFLCINNLNSLNANDVKYLDSQGCLRVPESNCLDNLIRTFFRYAHPILPVINEAEFWSSYDPLTSDDNTSRVPVVLLSAMLFVACKYVDDSTIQSVQLDSAREARDRFFRKTKLLYDHETESSPVVLAQVALLLAHWTPQTTSSCGRQSTQWLSRAIHHCHDAISQAQLWSTLRVRYNESNLRRLVGCCKLSDCIHSLYNRRPLMVLPGMANTESDHLVLSRADLSHEIGRSRVYGVEAKHRLIDAQEQMSSLITILGRALALVYPQVGTTTRRATSTHDEDKYEFINCKNELRIWYSGSDVFPISGQDSALGSPVSPDGDSEYGSSQHDPVELLGSMMHLHYETAMLALCQSELLRLTVNPRTTYSTSRRQQPLLSEPERQYSSCILKMADQLSHSLQRQHLCRVPESMILCTVLPLLLHLPSSMSSGQQVIEAQSCYPDWVQKVMGCLRLYFRNEFEFILQAVKIFNNSIAQSSQEDDGPQPSEGQPHMSGWRELLDTRPELFARLIERLDTVICWGGDLPKTYTGILVDDSQARTSPTLTRQFRATGISPTLTPHVASTPSRRRMEKRSSPILCEDKPEAQLETGSADSSLTSSGGLRESFSDVAYSYLDGVPEKTYSPTSLDTSQRYWTEETVDDGRRDQATTDGEIKPSAIDSIDVDNIMLEDGLSDDWIDALLEQDMSLQGDNAGRSVEDVDMAAT</sequence>
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    <accession>A0A098DSJ6</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DSJ6"/>
    <dbReference type="EnsemblFungi" id="CEF84337">
        <property type="protein sequence ID" value="CEF84337"/>
        <property type="gene ID" value="FGRRES_13553"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DSJ6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF84337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="98" mass="10679" checksum="D1543213425D85E2" modified="2015-01-07" version="1">MVVLTGKQCWRGDMEGVFSNLANGMEMGDGMPAECFWNVRGMLSGIAILARNALGRRSEALPRMRLGNGPYGVALIARTRGSWRAIYVEMSEVVSLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DT69</accession>
    <accession>A0A0E0SDP4</accession>
    <name>A0A098DT69_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 4, complete genome</fullName>
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    <gene>
        <name evidence="8" type="primary">FG07483.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T24925</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DT69"/>
    <dbReference type="STRING" id="229533.A0A098DT69"/>
    <dbReference type="EnsemblFungi" id="CEF84557">
        <property type="protein sequence ID" value="CEF84557"/>
        <property type="gene ID" value="FGRRES_07483"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SJS5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DT69"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="149"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF84557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="382" mass="42222" checksum="C359E45554761704" modified="2015-01-07" version="1">MRKLWNPKLKEPTIILYDRDSPDVTAQREGYTVSLAGYDTSGGLLALRKLDLLDEILDNAVAGLNDDGAFKIWGPAWNEFASFRHKPIDGLPSSSVRIARKDLRQVLHNNLRPSDAVQWNSRCVSARRLEDGRVCVQVAKGYNESEMVSEEICDVLIAADGANSKLRTNLRPEDGLEFAGAILRGGISRFDGPPPTPINKDWGFMLSGTGASCFFSPVDKNSVVWGVGHLEADQVPRLDLNDEEMVQQVIETCLQLGKELQEPFRTIVHYTDPKTVFAINAHDKKPFHHEEIDTIPVVFIGDSNHAVSPFAGFGANLALCDGLDLAQKLCNGQSVEDSVMAYDDLAVSRAFPILQRSRERLISGHRSGGMPRRTGERQTKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DV61</accession>
    <accession>A0A0E0SH63</accession>
    <name>A0A098DV61_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG09084.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T27965</name>
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    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DV61"/>
    <dbReference type="EnsemblFungi" id="CEF85776">
        <property type="protein sequence ID" value="CEF85776"/>
        <property type="gene ID" value="FGRRES_17157"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27965"/>
    <dbReference type="eggNOG" id="ENOG502QWJU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DV61"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF143">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C X DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF85776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="603" mass="65181" checksum="6941CD38D64E2CC0" modified="2015-01-07" version="1">MGVGAYLQILNGTPYTFTNTNRSNTGYQMNSWDPSASIPPGASDFSYFEFDEGVFVNESNTQVTSTYAIGETGRSFSIRAEDDPPRLYARIDGFSTSAMPEGEWLALEFVHSGGNPFVLSGTIKNMSTTFQPPDWMHQNLNTLGNLPLKRICMPGSHSAGMGVLNPVGTAQENYASGTGSLLKTQPTTIYQQLVNGSRFLDVNPVMVAEGDFRAGSFPTNPPVDEHGCCGQSMSDIISDINKFTRQYAELIILDLSHGYDATNGYTDLSVSQWSTLFIQLTQNLSNLALINADYTTGRVFNNTLNSFIGSGTASVLVCLDVGGMSPDPSFQGKGIFSQANLLTNNVCSNTTNVDSLDIDLLSKLENYPTDSSGQVIDQLQLVSWILTQRHPDSGIEALANQANLNLFKNIIGFCSASAFPNVILVDWLKNTNTAALAMAINNKVYGNANSGNIPSPTQQYVSSLTVQTSGDSDFFPLGTCVDESGRQGSPDCNNSFSGDYTYVVKTFTTNPSQAITGLSIHITGYKNSWLGGDMANDAGGDFRYVVTSQDLTLPTRISNVQLWRSPDDPVTLADAVGWDGISTDINHGRSGAYLYLVWKNARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DVQ6</accession>
    <accession>A0A0E0SG79</accession>
    <name>A0A098DVQ6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T22429</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DVQ6"/>
    <dbReference type="EnsemblFungi" id="CEF85442">
        <property type="protein sequence ID" value="CEF85442"/>
        <property type="gene ID" value="FGRRES_15365"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22429"/>
    <dbReference type="InParanoid" id="A0A098DVQ6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF85442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="52" mass="5534" checksum="B458340B8CEADA56" modified="2015-01-07" version="1">MLREHGLADEQGYGYGYDGPSLVGAFRFEDAPGGNFSNGCSWMKSGGGWLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DYT7</accession>
    <accession>A0A0E0SJA9</accession>
    <name>A0A098DYT7_GIBZE</name>
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        <submittedName>
            <fullName evidence="15">Chromosome 3, complete genome</fullName>
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        <name evidence="16" type="primary">FG05182.1</name>
        <name evidence="15" type="ORF">FGRAMPH1_01T17297</name>
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    <organism evidence="15 17">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DYT7"/>
    <dbReference type="FunCoup" id="A0A098DYT7">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A098DYT7"/>
    <dbReference type="EnsemblFungi" id="CEF86522">
        <property type="protein sequence ID" value="CEF86522"/>
        <property type="gene ID" value="FGRRES_17654"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17297"/>
    <dbReference type="eggNOG" id="KOG0998">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 3"/>
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    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003779">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:endocytosis"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="UBA"/>
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        <property type="entry name" value="UBA-like_sf"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
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        <location>
            <begin position="15"/>
            <end position="91"/>
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    </feature>
    <feature type="domain" description="EH" evidence="13">
        <location>
            <begin position="149"/>
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    </feature>
    <feature type="domain" description="EH" evidence="13">
        <location>
            <begin position="292"/>
            <end position="383"/>
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    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="325"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="12">
        <location>
            <begin position="1209"/>
            <end position="1249"/>
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    </feature>
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        <location>
            <begin position="107"/>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="235"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="737"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="395"/>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="469"/>
            <end position="481"/>
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            <begin position="486"/>
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        <location>
            <begin position="898"/>
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            <begin position="938"/>
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        <location>
            <begin position="966"/>
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    </feature>
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        <location>
            <begin position="1009"/>
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        <location>
            <begin position="1031"/>
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        <location>
            <begin position="1080"/>
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        <location>
            <begin position="1120"/>
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            <begin position="1174"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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            <dbReference type="ARBA" id="ARBA00023203"/>
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            <dbReference type="ARBA" id="ARBA00023212"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
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    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
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    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CEF86522.1"/>
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    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1250" mass="131980" checksum="C0D0210F27AC34FC" modified="2015-01-07" version="1">MAADEAPNLNLSPDEKRTYGQLFRQADSESVGVVVGEIAVRFFHKTGLDSRILGEIWQIADKENRGFLTPAGFGIALRLIGHAQAGREPTPEIALQQAPLPRFDGIAPQPTGGIPPPPPVPVSSPPPPAALQAQSTGGPIRIPPLTPEKVTQYTGLFERQPLQNGQLPGDQARGIFEKSGLPNEALGRIWQLADVEQRGALVLTEFIIAMHLLTSMKTGALRSLPSVLPPGLYEAASRRGPVPRQSSTGPGISAIPRQLSGTAQVRTNSPLGRPPMSPQQSGASDWAVTPADKARFDQIYADLDKGNKGYITGEEAVPFFSQSNLPEDSLAQIWDLADTNSQGQLSREQFAVAMYLIRQQRTGRSVTLPTTLPANLIPPSLRSQVRPHTATSAFDPPPAPVIQAPPPQPKSALDDLFGLDSGSSTPAPPPPAQAPMSTGGSNANDPFAGGSSFTPTSPGKPSLTGNGGSSFKPFVPSSSFGRGLTQHPTGGSTGSGQKLSAPSASEDLLSDNDEASKNISGETTELANLSNQISSLSKQTQDVQAKRTTTQNELGQATSQKQNFEQRLAQLRSLYEKEAQDTRALEEQLSTARKETSKLQAECMTLEGTYRDVQAQHQKTLEALQSDKQENTNLRERIRVVNGEIAQLKPQIEKLKSEARQQKGLVAINKKQLSTTEGERDKLKMEAEDLGKSIDDLRQANTSSPVSVSAQIASPAASVSSANNPFFRRTASTDIMGAFASPPPTKNASDKSFDDLFGPAFPPSSSATPPPAAQSGFFKPQHTGASNASAGSYNTPPVQGSPVMSRQATLAADPPAPPESRQISSSFLPFPDQTDSLSSSRQVSPPASRNDDPLHGSITPVPGDFKSSDSVGSVPGAFPGDDLDKSESKDTLSAPNDAPREATKDDESKPADSADPFGGHDEAKAKADFENAFAAFTTAKTQSKPSPEANKSSAFDSEFPPISELERDEEEDSDSSSDNGGFDDNFTPASPPAKPAAEGSPELTHAAPDSTSPQPAQEANSPQEPKAPSAEQPSSPATITETNAQKSSVDDIFGAAATGTAPVSQQAAPSNPPQNKGGFEDLDSDFEGLEDAKEGSADEDFANISRSGLDDFNPVFDSSPPGSQAKTESTAFGNESFDFVSASSTGPTQPAAGPQQQKAPEAHDWDAIFSGFDSPSAAAAQPAPADKPEGPEPHPGQQALNRTFSTESEHDDPILKSLTSMGYKRSEALDALEKYDYDLDKAANFLASRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RT18</accession>
    <name>A0A0E0RT18_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FGRAMPH1_01T05175</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RT18"/>
    <dbReference type="EnsemblFungi" id="CEF74393">
        <property type="protein sequence ID" value="CEF74393"/>
        <property type="gene ID" value="FGRRES_15939"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05175"/>
    <dbReference type="InParanoid" id="A0A0E0RT18"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="101"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="196"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF74393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="271" mass="29142" checksum="5C30D9D2CD7B9AFB" modified="2016-04-13" version="1">MAPDKKTKEPFWLGGAAACMAVCFTHPLDQTKYRMQVLKSNSSMLNVLYRFAARDGIPSLWTGLSASILRQGSYSTARFGFHTYFSDKLRGYTGKPLSVTQNIACAGVAGGVAGLVGNPAEVVLVRMCADGAKAPGQQFGYNHAVDALTRIYSEEGMRAFWKGLAPNIARSALMNVSQIATYASAKQYLVANGFGDDVKTHAISSLAAGTMATTICAPADVLKSRMQSNAGKEGLAQVLRAGLREEGPRFLMRGWTPAWLRLTCVAHPSYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RTZ7</accession>
    <name>A0A0E0RTZ7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T05835</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RTZ7"/>
    <dbReference type="STRING" id="229533.A0A0E0RTZ7"/>
    <dbReference type="EnsemblFungi" id="CEF74722">
        <property type="protein sequence ID" value="CEF74722"/>
        <property type="gene ID" value="FGRRES_15993"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05835"/>
    <dbReference type="InParanoid" id="A0A0E0RTZ7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="550"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="3">
        <location>
            <begin position="37"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF74722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="694" mass="78340" checksum="18612440E1199490" modified="2016-04-13" version="1">MAKPTLHESDGLLNPNNNMDRSVDNDSKESTKKMDDWKVSLISGSCACTAVFIINLGLTIWSGVSLKDAADSTETSRRIMYEGTCSTTRNINLVIHLIINVFGSILLSASNYGMQCLSTPTRADVDRAHAQGKWVDIGIPSFRNLWKVSLWRVVLWWLLVLSSIPLHLLLNSVVYSSLSSYSYEVFGADRNLYLIEKDSDLPARKSTLATFKSRNMLVSQLDNLTASECINEYGTTFQTKRADVILVFDFSMSKEESNQTYEINSALSHNVRRGDCIETDYDWICANESCDTPCHFLLPEIKRQPDNWKPYRLYDNKVKYCLSQPAPQRCRLNFDITLASIVLVVNFVKAIILAFIAFRPPKEPLFVLGDAIQSFMTRPEENPRGSCLISAHSVRNDLLDEPGLVHTAPKRRGAAISYTRWFFSLAMYGVTLGVSCWLLYYGISQISDRHDFKSLWGLGFGTANELTLITGWGFSNGLQHEQNIFRQVLVSNIPQFIFSMLYFHYNSLYTAMAAAKEWSDFGHKRRPLRVSSSPRGQQRSRYFLQLPYRYSIPLILVSILVHWMLSQCIFVVIVESYIKIRTEFQYQGTVVTCGYSPIAIICVIITSGLMAVAVFTTALRRLPTGMPVAASCSVAIAPACRQPDGFSHPEEAPLLPLQWGVMTIEREGSDREITDHCGFSHESVEKPEDGHAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RUD7</accession>
    <name>A0A0E0RUD7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T06115</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RUD7"/>
    <dbReference type="EnsemblFungi" id="CEF74862">
        <property type="protein sequence ID" value="CEF74862"/>
        <property type="gene ID" value="FGRRES_16012"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06115"/>
    <dbReference type="eggNOG" id="ENOG502SSWB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0RUD7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF74862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="352" mass="37833" checksum="628A70E93442A467" modified="2016-04-13" version="1">MNFVNEMPPEPTAPPILNLHGRAEASDQIVLSIAPDSICGFISERAGASRACPVNNRCYFFPPQSKEHGGVICCGKTTCQYHAACVNSREYFQLSKCDGGCEVDNYTLKWYHYSPRYPLEKPTNGMYSTDSRAPYCNTVAWRGNTTDYWCNDLDIKTAQSAALTYKGQKETPHFITVDQDDISSIESQMSGARTAGTALGGPKSTSESTSGSTATVTETNANDGGSSKTPVAAIVGGTVSGIAVLAAAGLGIFFFLRRKKKKQSNAASLPGYQQPPENKSPWSPGQQLVAPYHYDPNTPQSNVSPNSQCMYPQASGFQPQQNVIHEAGGEAVDPSSQPQELPANKKEPAELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RUG8</accession>
    <name>A0A0E0RUG8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG02579.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T06177</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RUG8"/>
    <dbReference type="EnsemblFungi" id="CEF74893">
        <property type="protein sequence ID" value="CEF74893"/>
        <property type="gene ID" value="FGRRES_02579_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06177"/>
    <dbReference type="eggNOG" id="ENOG502RM5N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0RUG8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="489"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF74893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="707" mass="80044" checksum="B6CC657AE92FEB9E" modified="2016-04-13" version="1">MLRSINRLAKSRVSIRRDDLTWTYKAKCYSTETSPETPPSPSHSPDQEATEEAIEEARMLKAVVEERMRSIAEKERIKSVVERARLQRKAIEANAITKVTTSKTTVVKGLAIKRAAVKGITTRTIPTRSVSIKSTTLKDVATGNAAARAAIAKDITAKNITAQDINTTNNTTKNTVVKNPTTKVTIAEDAIAKVIIKEDVTAKVAIEKNTAIQKDTKKASIPQDKSTKKAIMKDAVMKTVTAKAPPTKDVTAKDTTTAAPKAGSSTPVRSHRTVGAANKRTPNRIRQQAHTKSRMSRKRSQKGNPSSNGPPSEPPLLSELPELTFQPDPSLAEGELREEELTTKLLPKQQPLAEDDYWRLRRENFSQDFLKNLGRLKSMSNDERNENIRNTYGWSLEVPYSRELYYSPKNRRTNLILRKRFAALQQLRLIMGYGANTDFRDEWLDDLPYRLKKTSMRDVRFICIDTDMVRRLPYTLRDETKRRVTSFHLGVAILDTRDIRDVITRSINLPNPSDLIKTYEFAVQTEVPQTDNFIFGETQAISLSGLKKKFLEWQHGRTVIGVAYSARNDYIILRDFGVFFNHIYWLDLCQATYLITQQSKAINLREVLELLGIRYSKLHSAGNDAHFTMRALMGLAVLDLTNELQYGAHLQPWCGLAARIAKAPLPLTEREELKRKERQLAERKAATTNWHRKRSLSKVPLPYPGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RXU0</accession>
    <name>A0A0E0RXU0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FGRAMPH1_01T08525</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF76065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RXU0"/>
    <dbReference type="STRING" id="229533.A0A0E0RXU0"/>
    <dbReference type="EnsemblFungi" id="CEF76065">
        <property type="protein sequence ID" value="CEF76065"/>
        <property type="gene ID" value="FGRRES_17401"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08525"/>
    <dbReference type="eggNOG" id="KOG0684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0RXU0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF76065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="553" mass="62625" checksum="137D646BDDCB15C5" modified="2016-04-13" version="1">MDRVISNTALSPTSLVVLCVVIAIAVTWLRSSNSNQPPRLQDKIPYITNTIQYLTDAGRFIDRVKEKLEKANSDIVRFNVGFIPAYVVRGPDNVRKLFNSPNTLDGNFLQLLLMDKHWGMHHHEIAKFANDKTGRGKAPAPGTETVPESERYWLGHDRLYVNYLANRQNSDALADVFHRTFLQQLNSLSEEWSTINLFETLKTLMATSAITSLFGTRIFDLNPDLINVYWQFDDIAGHLVWGLPKFLQRRSVATKDRLHSMTLKYVNSAWENFDWDSSESESPWDPHFGSRLCRETAKWFRENNFSNHAAAGHAVGALFGLNGNTIPITTWIMMHAIQDPVLFEALRKEALSVYEDDPLTGERHVNTQKLINLPLMQSVYVEAMRVHVSFNVTRQASQPLAIGGYAIEKGALVQACSKIAHFEESTWGVEGHPASEFWAWRHIKSVASVDSATGKAVHQDQFAMKGRPSSFFPYGAGYVMCPGRFFAKQEILLAVAILVANFDIEFEQWIKEDGSDSDRPAQDDGRYAAFIAMHPDREMVIRCRRSKDIAKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RZN6</accession>
    <name>A0A0E0RZN6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T09817</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RZN6"/>
    <dbReference type="EnsemblFungi" id="CEF76711">
        <property type="protein sequence ID" value="CEF76711"/>
        <property type="gene ID" value="FGRRES_20126"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09817"/>
    <dbReference type="InParanoid" id="A0A0E0RZN6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="131" mass="14407" checksum="51CB8D68ECB8D09D" modified="2016-04-13" version="1">MISAATAPFLAHALIETPAALTFILKPSTQLQPLPPSAALIVQSFGGCILTTNLIALIFLRRPFDHVAQHVALAFAFWHIWPCYRAYMRMNGYTKEEGTATTKTLGGPVVHLRVHVVLLTMFLGTWLFGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0S814</accession>
    <name>A0A0E0S814_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG04601.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T15679</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0S814"/>
    <dbReference type="STRING" id="229533.A0A0E0S814"/>
    <dbReference type="EnsemblFungi" id="CEF79639">
        <property type="protein sequence ID" value="CEF79639"/>
        <property type="gene ID" value="FGRRES_16086"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15679"/>
    <dbReference type="eggNOG" id="ENOG502SNEG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0S814"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF79639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="283" mass="33129" checksum="1A2DD6AA77A5D346" modified="2016-04-13" version="1">MANCYQAVFKYYFMWQYAKASWKEMSMWMRLPWHPNIVSFDRVVIDELNGSVVGFNSIHVPGGNVEDNKSHVFKMKWLHQLIKVVDELNLIYGISHQDIAPRNLLVNEVTDSIMLFDFNFAARINHPPEEGEAYDETRNDIKGVIFTAFEIITQDDRIRSMPHEDQNIDDLGLEWVKHPDVTLDHPVESYQILLQEWKKRRAEHVYRAKDARSIDWPSMSKPPQKSYRATTVNRESLDTMVDNFYERRQSIWARGERGVSWERPPQSLLDSGTRVLSTGEIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SGX3</accession>
    <name>A0A0E0SGX3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T22703</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SGX3"/>
    <dbReference type="FunCoup" id="A0A0E0SGX3">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A0E0SGX3"/>
    <dbReference type="EnsemblFungi" id="CEF85686">
        <property type="protein sequence ID" value="CEF85686"/>
        <property type="gene ID" value="FGRRES_12946_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22703"/>
    <dbReference type="eggNOG" id="ENOG502QRAQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0SGX3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
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    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
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    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF3">
        <property type="entry name" value="5',5'''-P-1,P-4-TETRAPHOSPHATE PHOSPHORYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="3">
        <location>
            <begin position="153"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="2">
        <location>
            <begin position="204"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF85686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="340" mass="37086" checksum="6D96645BCB14E3B2" modified="2016-04-13" version="1">MPRIRAPSSLPNLVKSTFARARSDGDLHYFPTQVAVLNVDSIQFQLRFSPSLANKPKPPPKDNSKLQKPFDPFENPLPALKVTDLGPSHYCVLNKFAVVPEHFILATNDFKPQTHVLEESDLEATLACIEAYETARGSETEQGHQDGALGGGDGLYAFFNCGDHSGASQPHRHIQLLPIARMKDGLEKDTSWTVLADELKIKTAPFATFTEDINLDMSGSKLHAIYLRLYRRACRAVASYTKDATHEGQAPADGPTLISYNMAMTKSTLVICPRLAEGVKLQSKDGNVLGTVAFNGTLLAGTALVKNELEWEMLKKDPDVLRNILGGIGVPSAFEADASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SHK9</accession>
    <name>A0A0E0SHK9_GIBZE</name>
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        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG05109.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T17121</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF85922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SHK9"/>
    <dbReference type="FunCoup" id="A0A0E0SHK9">
        <property type="interactions" value="471"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A0E0SHK9"/>
    <dbReference type="EnsemblFungi" id="CEF85922">
        <property type="protein sequence ID" value="CEF85922"/>
        <property type="gene ID" value="FGRRES_17649"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17121"/>
    <dbReference type="eggNOG" id="KOG0277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0SHK9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
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    <dbReference type="GO" id="GO:0062137">
        <property type="term" value="C:cargo receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="102"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="249"/>
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    <sequence length="352" mass="38822" checksum="9778485500ADECEC" modified="2016-04-13" version="1">MAAMLEYRTQGYNPYAVKYSPYYDSRVAVAASANFGIVGNGRVFALALTAQGIEVEKTFDTNDALYDLAWSEINENQLIVACGDGSLKLFDLGVNDFPVMNFHEHKRETFSVCWNPITKDTFISSSWDGTVKIWSPTRNHSIKTLPIGTCTYSTSFCPSNPALISAVSSDSHLRIFDLRTPSSAKYHLTATIPVHASGPQPSPGASAPAEILTHDWNKYRDTVIATAGVDRILRTFDIRNPAGGPLSVMQGHEYAVRRLAWSPHSSDTLISASYDMTVRLWNDGSMQQQQQPQGPGMAPSIGTQMGVMNRHTEFVTGVDWCLFGMGGWVATVGWDERVLLWDANMLMGQRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YHV5</accession>
    <name>A0A1C3YHV5_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T00855</name>
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    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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        </source>
    </evidence>
    <sequence length="2234" mass="248535" checksum="E324AAFA515D2253" modified="2016-11-02" version="1">MEAQRYPRYERSRSPRDRSPDRFDRGGAQYGDGDRRRPSEVRPGNGGFPPNRDFGDPLRREPPRGPKALIDAPSGPRGGGFGGEFRGRGRGRGRGWSSRDDSRDRGRDRDMDFRDRYRDDRSRERDRERDWREPRDFRSRRSPIGRARSPNRDFRDRDRDGPLGVDADRSRRGSRDGGPPSAGSSSSDPQFNMAPYARGGGFHRGRGRGRGDWSSERGRGRGPYMEDRGDRYPRSRSQEGRWGRERDERDRMERMDRYADPDTRHNNRGDERGDPRDRELFRNKMEARANAGHDSGLSSKEVSPPPPVAPSAPAFGPSAGRLSIGEGYVSASAATKIPPTAPRAFGDRPPSAGHDPAMPPMGMGMGMGMSMGMGMGMGMGMGMGKTMLHDGPSIPVGPRAQQPPPPRPSSKQWINPNLKKAPDSPKMMRSPSFVQQRPAMRRGSSQYDHYNEDERRPRSSDAKSDTHYDNRARSNYSAEPGEITVKSERESQSARASIDRDTRPINASRRDSYRSGPSPTMENMPRFSQIAEERAREMREPPKEAPRRKRVRPTLKVVRFEVPPKPAPVEQNSESDDDDDMADYFDMEIGKTEAELSKLEKPKLPTQVIARFAALSHGSMVKIVGEQDELLKMVEELPEAANKLAVEKTKEPVPEEQNEKPDVEMTDAIENATPVKPEPPQQPQQEDIKLELEPEIHVRRSEEPVVELAPKPLPEATKETTEPVIEQPTEKPEKSLESVAKPAEKPAETQLDEPIAQPDKKSVQLAKHASKDLEESSNEKPVEKVIEKPVQDVVEDSAPEPVVENAKQGPVASASEPEAEKMDIDEPAVEAAPAAPETTIPVTDRTVKDPVPTTSETVAKELPVEPMEISDMTIRTSNEAPAEKPEEEKPSEMSVETRPETPSQVQAERPNDSPSETSPGKRNQTVVETPVKAPAEPQFQTPAEKSEVTPHRHIRSENTPLSVIAPNIVLQTTETASKPPSTPSQVDDDETESEDDSFMNLDTVRQYMTTPPIDSLPNFSCQPWDQDKEFMSNLESDSFLDDFVLEHFDKLHLEKTAEQGHDKKIYSENYHHYLDFTMSNDPAAVKSRGKFSVSTGIEFTGTVTPEPKHEGSGRGRRFATERDLERVLQASMREDEERRERELRMQQEKYRTDKEAVIPDMIWTQEEKDSTNYIDKSGYTPVDRLVSAWRILPPVNNFTEEEANLFEKRYLEAPKQWGRVAEAIPHRNFGACIQYYYMNKKNLNLKEKLKKQPKRRRKGKAKQRSSALVSELGNGDGETEENHDTGENGERRRPRRAAAPTWGYEQPPIDTEASTPNATPGRRGGSVKVDHPEKVDGRKRRRGPKEKEPKAPKSNQTLAAAPGPAKGRSRSNSRALNTDGTTTPLPLPEGHRLPTQFEQHPAGIQPPFSVQQQPIQTLERPPPVASASISEVMAAPSLRPDPPPQPAMATFNLTHQPSERKAPTQASSYWSVSESNDFPHLLRSFGLDWTAIAAHMGSKTAVMVKNYYVRQKDQGKSEWEGLALEAERKKDCGEKLPDPPQPSTGGRGRRYDSSTAASRPLAVAPGIEMHSEAPQPKMEPAGQPPRGPQFSTFGGVPIAQAPAQQQQQQPLVQSQQPMVSQHPVAQPVAQVMSPVPRPLQAPVQQFRLNEREPAARVPLPQKASSRPPGVESREQRPLAAAQPLQPSRNEAAMMEHNAMMERQKMEMQMREQEQQRELARQSERQTLRVKQEREMTPQPHHYEPYGHHRQQGSLGSLGGQPMPRPLQESGRPQSYGPPVQQQQQQQAPVQPVRNLMGEQPQARSPQMGTPTSRPVSSLQQRPSSGSMHDTFGSVTPQSGTPVQTPAAAPTRPPEPRKGGLNIMSLLNDDDPPPQPKRVNDVTSTPARPSPTPPPQTNMGGRPLPGPAPPSQIRREPESYSPYARGTPGMPPLKPTFADSPQPQHMGASRASIGVSHEAAAAAERDYYRQNPYQSANHSRTNSPQGGHRYPPPGPPQYQNQGYPTSYASTGQPAHAGSPGGQYGHPPSSSRSREVPQGGRETSWPSPAQQGHPSMQQPAGWPSQPNTSQPPPQQQSWPPQHPSSKPQTPGPSWAASQPPSQPPPQQGHHMPMRDDGRAPYYPGGGNMPQQHQMQGRYPPPVSRGPEQVPPPGQGYPRYASTPGPGQPRDHREMSGRSFTPAYDARGPPPQGGPVYPGHDPRDPRDPRDPRDPRDMMRGALRPHEFERHPDPYSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YI39</accession>
    <name>A0A1C3YI39_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T03267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YI39"/>
    <dbReference type="FunCoup" id="A0A1C3YI39">
        <property type="interactions" value="1128"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YI39"/>
    <dbReference type="eggNOG" id="KOG1769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YI39"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16116">
        <property type="entry name" value="Ubl_Smt3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000155">
        <property type="entry name" value="Ubiquitin-like protein SMT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="36"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB64217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="115" mass="12708" checksum="5155C907200D92A8" modified="2016-11-02" version="1">MSTTIVQRTKHNNKSPIMSDENANGTPGEQAPANSEHLNIKVTDNNNEVFFKIKRTTKLEKLMGAFCERQGKATSSVRFLFDGTRVQPTDTPDALEMQDGDTLEVHQEQVGGSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YIN5</accession>
    <name>A0A1C3YIN5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FGRAMPH1_01T05811</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YIN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05811"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YIN5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF168">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SCB64417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="438" mass="49409" checksum="93CBF2B0E6F9E73D" modified="2016-11-02" version="1">MAVAALINYLRDLRPSIAIAASLVLFLAAWTALSTWRQYIRLRQFKGPTLAAFSKWWLVKKVGGGRAYLDFWEVTQKYGTIARVGPNDLLTDDPDLMKHILNVRTEYRRSDWYDGMRFNPGNNNILSHRDEDEHFKLRSKMSAGYGGREVENLEPKIDKNILSFISLLAKYAEAKKPMDLGRRAQFFTLDVISDLAFGEPFGFLETDSDVYKYIQITEETLPAVMVTTVIPWLVKILSSPLFKSLLPSEKDRLGFGKLMGIAKKVTAERFGPDKKVRKDMLGSFVAHGLTQKEAESEILLQIVAGSDTTATAIRSTMLHIITNPNVYSKLRAEIAGTHYSEPIIPDSIGRDLPYLQAVIKEGLRIFPPVAGLMSKQVPPQGDTWKGQFIPGGTKVGYCAWGIFRREDIWGSDAGEFRPERWLESDPEKLKEMEAPSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJ48</accession>
    <name>A0A1C3YJ48_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T07713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJ48"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07713"/>
    <dbReference type="InParanoid" id="A0A1C3YJ48"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SCB64593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="178" mass="20504" checksum="A224E3ACBECFA75A" modified="2016-11-02" version="1">MSNKQRWPLGYFNQSCAKLLCRPWTEAEFAEFRRNDELDVIYQVCLFWLFGSKDELFNQFADTKTDLTPVGDKGSTVNNPVRFFHGWSMDLLDYNLPRGYRVIRITHIDTRIETADGYKAFLPYVSIEKDETLATYITRVGDEGLVKIGVKKEVSDALFKTQLSAIKFLWDGSSASHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJI4</accession>
    <name>A0A1C3YJI4_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="6">M1Pi</shortName>
            <shortName evidence="6">MTR-1-P isomerase</shortName>
            <ecNumber evidence="6">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MRI1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T16975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="6"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJI4"/>
    <dbReference type="FunCoup" id="A0A1C3YJI4">
        <property type="interactions" value="742"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YJI4"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16975"/>
    <dbReference type="eggNOG" id="KOG1468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJI4"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SCB64688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="391" mass="42338" checksum="F0CC3563546F257D" modified="2016-11-02" version="1">MFIMSTLQAVKYTRGQLQVLDQLRLPHEFHYDDVSNRTEAFDSIATMRVRGAPAIAIVAALGLAVELQNGSITASDAEGTISQIDEALDYLKESRPTAVDLTNAINQLKATIREVGSSATKDQVISAFIEEAEKIFEKDLQTNLSIGDHGAEWLRSQAGASPDQKISVLTHCNTGSLATSGHGTALGIIRTLQSKDLLQHAFCTETRPYNQGSRLTAFELVFEKIPSTLITDSMAASLFRTRKQEKNIAAVIVGADRVVRNGDTANKIGTYQLAVLAKHHGIKFIVAAPTTSIDLETETGDGIKIEERKSEELTQVTGAVIKPDGSVDESSKVRVATADQRINVWNPAFDVTPAELIDAVVTEKGAVEKGADGKFDFSKIMPERWAKITGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YK02</accession>
    <name>A0A1C3YK02_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Trimethyllysine dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Epsilon-trimethyllysine 2-oxoglutarate dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">TML hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">TML-alpha-ketoglutarate dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">FGRAMPH1_01T19497</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="21">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6),N(6)-trimethyl-L-lysine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:14181"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58100"/>
            <dbReference type="ChEBI" id="CHEBI:141499"/>
            <dbReference type="EC" id="1.14.11.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.8" evidence="5"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YK02"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19497"/>
    <dbReference type="InParanoid" id="A0A1C3YK02"/>
    <dbReference type="UniPathway" id="UPA00118"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050353">
        <property type="term" value="F:trimethyllysine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2020.30:FF:000002">
        <property type="entry name" value="Putative gamma-butyrobetaine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012776">
        <property type="entry name" value="Trimethyllysine_dOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02410">
        <property type="entry name" value="carnitine_TMLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF51">
        <property type="entry name" value="TRIMETHYLLYSINE DIOXYGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="19">
        <location>
            <begin position="86"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="18">
        <location>
            <begin position="187"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="461"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="SCB64868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="476" mass="54879" checksum="EFFAB7E009D23E61" modified="2016-11-02" version="1">MLLSRLARSSISGLSSRQATLAARCIQRHTAVGFNLAAPPPAALMRWSSTGSETERANPVKAETVSFEDGSTRMRIVRPREDGSTEHRTFHNLWLRDNCQCSECVNPDTRQRNFDTFKLDSVRPQEFFQHETHLEVRWDDDHRSIHPWEWLECWFPGGFMKEVRIDEPPQLWSSRIAENPPKVDYRLGAEQIMADLTRNIWVYGFCLVENAEPTPEATQAFLEKIGPIRNTHYGGFYDFVPDLALADTAYTNIALAPHTDTTYFSEPAGLQAFHCLEHEAPPGHNPDEPLGGESLLVDGLQAARLLKRETPNLFDTLRDIRVPWHASGNKGIAIAPDRTYPVIEVDNETRRINRIRWNNDDRGVVHLFDSPPWYVAARQWNDIINRERSQYRFKLTPGTIVIFNNWRVMHGRTAFKGTRRICGAYIPRDDFVSRYRETNFEHDRVIRHNLNLCAGHGSSTVRKDSPTPDRLRRIWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YK58</accession>
    <name>A0A1C3YK58_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FGRAMPH1_01T20357</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YK58"/>
    <dbReference type="STRING" id="229533.A0A1C3YK58"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20357"/>
    <dbReference type="eggNOG" id="KOG1411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YK58"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000026">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="18"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SCB64939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="388" mass="42727" checksum="D8DC4F84A282B23E" modified="2016-11-02" version="1">MSSPPGITEAFKADKFDKKINLGVGAYRDDAGKPYVLPSVREAEMKVVESKLNKEYAGITGVPEFPPAAAKLAYGANSPALDRITITQTISGTGALRVGAAFLAKFFPGEKKIYIPQPSWANHKAVFNHAGLEVEQYRYYDKKTIGLDFEGLIADVKSAPNGSVFLFHACAHNPTGVDPTQEQWKQISDVVKEKGHFAFFDMAYQGFASGDTDKDAFAVRYFVEQGHNIALCQSFAKNMGLYGERIGAFSMVCADADEKKRVDSQLKILIRPLYSNPPIHGARIAAEILNSPTLYKQWLGEVKEMADRIITMRALLKDNLEKLGSKHDWSHITSQIGMFAYTGLTSEEMTRLAEEFSVYATKDGRISVAGITSENVGRLAEAIYKVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YL91</accession>
    <name>A0A1C3YL91_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T24087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YL91"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24087"/>
    <dbReference type="InParanoid" id="A0A1C3YL91"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020100">
        <property type="entry name" value="Glc-repressible_Grg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789:SF1">
        <property type="entry name" value="GLUCOSE-REPRESSIBLE GENE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789">
        <property type="entry name" value="REPRESSIBLE PROTEIN GRG1, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14210)-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF11034">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="107"/>
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        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB65198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="107" mass="11562" checksum="7BFE95154955FF51" modified="2016-11-02" version="1">MDSIKNTVNQATEKVQEGLSGTSKEANKEVAKDSNAGIGTRASAAKDAASDKVRYKSNQPGMSAIESWTGAQEMVEEINQEKRKSLTFPQIDESTHGAKSEAYKQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLD5</accession>
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            <fullName evidence="3">Chromosome 4, complete genome</fullName>
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        <name evidence="3" type="ORF">FGRAMPH1_01T26059</name>
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    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YLD5"/>
    <dbReference type="FunCoup" id="A0A1C3YLD5">
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    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YLD5"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26059"/>
    <dbReference type="eggNOG" id="KOG1470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YLD5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
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    </dbReference>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SCB65346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="449" mass="51448" checksum="A4B656563989A697" modified="2016-11-02" version="1">MSFQVPPGRPGNLTPEQEEKLRKLWVAVFQLTGVADEESSGAEILSPKEEISSADADQKKKRGFGMFKKGKSGTSTPTESADEDKYNETKQFHETLAKETPETIRHTIWSMVKHDHPDALVLRFLRARKWDVEKALVMLVATMNWRHNDMKVDDDIMKNGDAFAVEDEKTDSATKQVSADMMKQLRMGKSFLHGTDKQGRPICVVRVRLHKAGQECEESLEKYTVYIIETARMTLEPPVDTACIVFDMTGFSMANMDYTPVKFMIKCFEANYPESLGAVLVHKAPWLFQGIWKVIRGWLDPVVAAKVHFTNNRSELEDFIAPNHLIKELEGDENWAYKYVEPSPGENDKMKDTQTRDRLLVEREELVKKFEQATREWIRHPEGEQGKQIKSEREKIAKLLKEDYWHLDPYIRARTLYDRQGAIQSGGKTDWYSLKPPTAAASTSADDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-11-27" version="21" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YM78"/>
    <dbReference type="STRING" id="229533.A0A1C3YM78"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G28151"/>
    <dbReference type="eggNOG" id="ENOG502SBIR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YM78"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000271">
        <property type="entry name" value="Similar to ssDNA binding protein Ssb3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114:SF1">
        <property type="entry name" value="REPLICATION PROTEIN A 14 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114">
        <property type="entry name" value="REPLICATION PROTEIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SCB65533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="107" mass="11635" checksum="83D8260CC3539121" modified="2016-11-02" version="1">MSEQLSTPRITAAYLDNFVGRVVMLVGEVTQLRGDQATVESDGTVTVLLNRDAHLSNGNYVQVIGKVNPDLSIKVLTSRDLGNSVDFAMYSSVVQATHKYQSIFTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-01-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YM88</accession>
    <name>A0A1C3YM88_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T28245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YM88"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G28245"/>
    <dbReference type="eggNOG" id="KOG1802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YM88"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="1">
        <location>
            <begin position="383"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB65543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="575" mass="64848" checksum="50F0C2407D6A347B" modified="2016-11-02" version="1">MTASTLHHITIELLGSSTNVRELTDNEAKAFESYVSRDKTEGFRVLTLTPTTDKACGPRINGFGTSFHGVNATVDGYVNQETQICGVASLSEIFRRKDFTILPETFGYGEVHKWDISQYRKQVPNLRGIAFSPRVRFENANERDTALTQMHVQDVWDFNDALEDVAEMELPCLIWRVGEEPAEKTTQFVCLLEPDKIFRPHHWRAARRALHGDAIKLEVTFKPSKDVPWSVSWEASHLTFASSDHLRGVDLKRRLPLLLKRPEDNSRSHKFCPFSYPKYEGTGDDLKRRTVVFHCHLNLHSESLRVFAINHLSSPKISPSTMEADPRASSKQAIFNELLIGQGLWSLQKQGVNVELPSFDIFDGIPVDVRDACLKHVFENDKERVRRYFGKLHLGLGLVSGPPGTGKSHLASIVVILMCLNKSIKHVYVAAASNGATDNIVERIDGMAQTIIGTLLGSDVKHLMLLRGYSLGIEVENCTMALLNIPFKEDAIWNPSPWKFSRSLCWWTLRVLGSKRVPRLSADDNIELWNLQQRLNALIEPSSTPNDPELLKSRQLLKLAKGFESPVAYKSIVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMD2</accession>
    <name>A0A1C3YMD2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T10227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YMD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10227"/>
    <dbReference type="eggNOG" id="ENOG502RJ4Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YMD2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB65619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="136" mass="14973" checksum="0FDE30B9FCD024C8" modified="2016-11-02" version="1">MGWAQSSGAIIKTSLTTGPCADNFKRQRPNIDKSTQELTCSDVTESPGSSFKLDAILRSTNVEFSQSPLDPSPPELKDPYDDDLFDDLELDQYLESLTGPVSIEHSGPSLSLDDTDEFDLKQSDEDALDELLKQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMP4</accession>
    <name>A0A1C3YMP4_GIBZE</name>
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        <submittedName>
            <fullName evidence="7">Chromosome 2, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T11937</name>
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    <organism evidence="7 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YMP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11937"/>
    <dbReference type="eggNOG" id="ENOG502SITX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YMP4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="515"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="516"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SCB65739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="585" mass="65986" checksum="E14778ADCBBE7BB5" modified="2016-11-02" version="1">MSPSNDRRSPMPLLKTCQTCFHLKIRCEKTQDSDLCDRCLRLGKTCIFNQARRRQNVNRQRNGRERLGAQSVSDRSSKSPANRQQQARGSEADHDILNKDASLDPFEQGILTFEKGQSLLETFTRRFIPYFPFVLFPSDSSIEELNSQHPCACLAMLAAASYTEVGTQVALGNLFKQIVAVRMVDGDFNQLDLLQGLLIHVAWAHYQPKPKRYIQHLHLITSIISDLRLDRPRKPKLWSAEGGRYQNKPDWQPDEMRALAGAYYLSSSSSIILQKSRQVFNTTYLLACCEHLASLNQYPTDKFLPYITRVQTLIENIEDLVCKTATTDNGLQFFTECQEITQKCLDIKSTLPFPLSESPPLLLQIHILELMLSQSSPRGTAFGLDKFQNPFQDETTLNEWLSTSMSATRSLIGVILVMPQGEEVAMSNMGWIMMNCALNLAVRLDLIAARGSLSGFTQQLRRFLDMGHTLRQLVLRFEAVPGPDASADHPFHGIVKRVRRLENWYLSQVAQQTADSTSSISPSSGSQPSISLSDHTSGMPVSMPLPYQNWNMGGGSEWYQNPDLDISTFLFADPIDFPMNFAWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YN57</accession>
    <name>A0A1C3YN57_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T14913</name>
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    <organism evidence="8 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YN57"/>
    <dbReference type="FunCoup" id="A0A1C3YN57">
        <property type="interactions" value="144"/>
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    <dbReference type="STRING" id="229533.A0A1C3YN57"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14913"/>
    <dbReference type="eggNOG" id="KOG2159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YN57"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:CCA tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000019">
        <property type="entry name" value="tRNA nucleotidyltransferase cca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
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    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="6">
        <location>
            <begin position="86"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="7">
        <location>
            <begin position="259"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SCB65935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="568" mass="64593" checksum="96F198DED4546014" modified="2016-11-02" version="1">MLKRLSRSGFAMKRNIDSFLKDQYPLASDLNSFSTTPPSRILRRKYLMATAIIQLTPKEEQLRRLLLDVARSIDDSRQASEPIVLRWAGGWVRDKLLNIQSHDIDVAINAMTGVPFAQAMCDYCEQPDAMAKHSIGPADIGNLHNVARNPEKSKHLETAMVKMFGLDLDFVNLRKETYTEDSRNPQMEFGTAEEDARRRDATVNALFYNLHDDRVEDFTGGLADMDAKIIRTPLEPFQTFMDDPLRVLRLVRFASRLQFEIEPETRKFMADPKVLEALRAKISRERVGVEYEKMLKGAHPHQSLELIDELQLFHAIFTDPEHKNLPTPEISRWSVAYTCLDELLKDQSPTSVAGRLITSEDASSPFYAWNLAALTPWMIVEEPPNFRKKPSAYPPVAVVAREGFRAPNRLADIVAASYRHREAILELKEAVCSKAPYIDERDRFGMAIRKWDSPKDTWKLQVLNALLVDALETLPTWSREGSKEQTDFLAGWGKFLDHLAKLDLYEVTTLKKLLDGKGLVKALGTKPGRWTGPALDVCIAWQLRNPDATDPAGAIEEVQRRRTELQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RA92</accession>
    <name>I1RA92_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG00419.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T01093</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316085.1">
        <property type="nucleotide sequence ID" value="XM_011317783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RA92"/>
    <dbReference type="STRING" id="229533.I1RA92"/>
    <dbReference type="EnsemblFungi" id="CEF72347">
        <property type="protein sequence ID" value="CEF72347"/>
        <property type="gene ID" value="FGRRES_00419"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00419"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01093"/>
    <dbReference type="eggNOG" id="ENOG502T2BZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103881_0_0_1"/>
    <dbReference type="InParanoid" id="I1RA92"/>
    <dbReference type="OrthoDB" id="3559694at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024316">
        <property type="entry name" value="APQ12"/>
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            <begin position="75"/>
            <end position="95"/>
        </location>
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        <location>
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        </location>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72347"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="178" mass="20061" checksum="8CAF7A6382D0B586" modified="2012-06-13" version="1">MPSVDSPSMATHFITSFLPPELAETVQKHILSPRSPVQVVVRNVLVQAQNVIDTVTPIVEPILDRVMVLLAENQGLVGVIASLLVLATVVIILNWIRRLLMWWTRMAMRIMTWAFMFALAAWIWERGVFESARDMTVIGARILGYLAVIKDVWLQEYDRYEAQQGMAGTRGPASGRSR</sequence>
</entry>
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    <accession>I1RB77</accession>
    <name>I1RB77_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
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                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316495.1">
        <property type="nucleotide sequence ID" value="XM_011318193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RB77"/>
    <dbReference type="STRING" id="229533.I1RB77"/>
    <dbReference type="EnsemblFungi" id="CEF72784">
        <property type="protein sequence ID" value="CEF72784"/>
        <property type="gene ID" value="FGRRES_00784_M"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00784"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01967"/>
    <dbReference type="eggNOG" id="ENOG502SQ4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1875623_0_0_1"/>
    <dbReference type="InParanoid" id="I1RB77"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
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    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
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        <property type="entry name" value="Cutinase/axe"/>
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    </dbReference>
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        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF72784.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF72784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="136" mass="14393" checksum="DCF2A78A00E10081" modified="2012-06-13" version="1">MADIVNPGLFVWVFYLNHTGAHIAADVMCGVSSVGFPATKPQPLNITNKVAAIVLMGDPSTTKGQAFHVGSSKGDGVFSRQKPNGCRYVSGKTMSFCDAGDPFCEAGGHDLSTHMRYVSAYGQTATDFAVSMFHLA</sequence>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73017.1"/>
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        <property type="nucleotide sequence ID" value="XM_011318408.1"/>
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    <dbReference type="EnsemblFungi" id="CEF73017">
        <property type="protein sequence ID" value="CEF73017"/>
        <property type="gene ID" value="FGRRES_00968"/>
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    <dbReference type="KEGG" id="fgr:FGSG_00968"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02431"/>
    <dbReference type="eggNOG" id="ENOG502S78G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065222_1_0_1"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="SGNH_hydrolase"/>
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        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
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        <property type="entry name" value="SGNH_hydro"/>
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        <property type="entry name" value="SGNH_hydro_sf"/>
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    <dbReference type="PANTHER" id="PTHR30383:SF19">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
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        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SGNH hydrolase"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF73017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="245" mass="28015" checksum="9C573F0614AEA5F2" modified="2012-06-13" version="1">MPRKKLRILCFGDSLTSGYYCQGLMSHPYAAKLEDRLTGTFPEVDFDIVVSGVPGDIASSERFSIRTKTAWRARAYDWTIVLGGTNDIAFGIPPDVIFSSLKKTYDFARDKGAKVLALTVPECSADNERTMAARNALNERILKNKSRNYYAFDLRSKIPFHSLSQQDRHRYWDDHVHLGKEGYDWMGNHIADALIDILWHEGTFEQPSEPSDEVDVEEEFVYDEEDGNPHNINEGYIVVRKKDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1RCV5</accession>
    <name>I1RCV5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG01437.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T03533</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317242.1">
        <property type="nucleotide sequence ID" value="XM_011318940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RCV5"/>
    <dbReference type="STRING" id="229533.I1RCV5"/>
    <dbReference type="EnsemblFungi" id="CEF73572">
        <property type="protein sequence ID" value="CEF73572"/>
        <property type="gene ID" value="FGRRES_01437"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01437"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03533"/>
    <dbReference type="eggNOG" id="ENOG502SCMA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071095_1_0_1"/>
    <dbReference type="InParanoid" id="I1RCV5"/>
    <dbReference type="OrthoDB" id="1894652at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39219">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39219:SF1">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21203">
        <property type="entry name" value="ECM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124088" evidence="1">
        <location>
            <begin position="19"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF73572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="189" mass="20298" checksum="E51BCED2478F5C8D" modified="2012-06-13" version="1">MRIAGFLSTICAAALVVAEQRTAQIYVQAVQSSPSLPQPLAEIAYDAASLISTEVVSYEAPELPETASLVRIGIYDPKSEKWIAGTTAASTENFDRGYAPTLLLSVDESGDVRSVTLKGIRVDAGQTRDFGPKAIVIADKKGSQPELNKPVILSPGGKKAEEEEPKSFLQKYWWLIAIMVVMSLAGGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I1RCY6</accession>
    <name>I1RCY6_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG01472.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T03613</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_011318977.1"/>
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    <dbReference type="AlphaFoldDB" id="I1RCY6"/>
    <dbReference type="STRING" id="229533.I1RCY6"/>
    <dbReference type="EnsemblFungi" id="CEF73612">
        <property type="protein sequence ID" value="CEF73612"/>
        <property type="gene ID" value="FGRRES_01472"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01472"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03613"/>
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    <dbReference type="OrthoDB" id="185373at2759"/>
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        <property type="component" value="Chromosome 1"/>
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        <location>
            <begin position="681"/>
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        <location>
            <begin position="62"/>
            <end position="96"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="686"/>
            <end position="695"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF73612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="729" mass="82632" checksum="DF44659FB3CD39FC" modified="2012-06-13" version="1">MQALWSRAGRAHRCGCRRACDAVVSTLGRRVTTATRPRKVAIADVFTACYSSMFATAALVDAVIKEDRRQELDRLLEETRRELAQLQLQNLEASQSTTENISLGQMHHLWESIKDMHTNRPYMKEIYRPATIRIDEFLNRVQTEQYECPDKATMDAYRRTDYENLEQTIVHEETDDSIVHRRPMNSKQLHNAGRTVNHLIQQLLKRAAAHDKSNLPSPSFDEAVKFADQVPSYKFLVESDLEMMKKNRATLNLGLRKVVSSSLNLKEKVGRVCYNLLVSAYPADMHTYNTLIVAFDRHGYKYLAEAVVNSFYYYRRLSPTPSTFVAILNHYKDSGNYGRFLRSLSCITGLDNKTGAKVRRRLAEGFDSSRSRRNGIQTWTQTGDYFWQHAPLNKPVVEAVIHGLLRVNLIDQAAMFFVSCMKNEVILGTQIIKQLFDECIAALDWRSAVRLIQGFAHCSFTWPSMLLGRDQDTAYLIGRLRVLLDLAGLQNSTGEVSTSILDNLSIPNFGFRKFLSDLATADSTSQLETQDSTTGLVSSPGRRLLQIEALWKEQDFIAKTIRSIESKLLYPDLPQNFRESMASHIGNTAAKNVVGLNREIMEVLVRLPRSDRVEKGLAECKIFEDASVAFYENSTSVPRSKSNVSGALSDNSIFEKLMQSRWTTTGEQTDTELAVSLREDEPQIPLTGTTANKRTNPAGRKPLRARSMRRTTWSATDERVGYSERPSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1RDJ3</accession>
    <accession>A0A098D5X9</accession>
    <name>I1RDJ3_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="4" type="primary">FG01693.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T04119</name>
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    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317522.1">
        <property type="nucleotide sequence ID" value="XM_011319220.1"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF73867">
        <property type="protein sequence ID" value="CEF73867"/>
        <property type="gene ID" value="FGRRES_01693"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01693"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04119"/>
    <dbReference type="eggNOG" id="ENOG502S06V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002822_2_0_1"/>
    <dbReference type="InParanoid" id="I1RDJ3"/>
    <dbReference type="OrthoDB" id="3937590at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022124">
        <property type="entry name" value="DUF3659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054256">
        <property type="entry name" value="DUF6987"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461:SF1">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12396">
        <property type="entry name" value="DUF3659"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22485">
        <property type="entry name" value="DUF6987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6987" evidence="2">
        <location>
            <begin position="1176"/>
            <end position="1381"/>
        </location>
    </feature>
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            <begin position="7"/>
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        </location>
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            <begin position="120"/>
            <end position="135"/>
        </location>
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            <begin position="141"/>
            <end position="160"/>
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            <dbReference type="Pfam" id="PF22485"/>
        </source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1REJ0</accession>
    <name>I1REJ0_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptide hydrolase</fullName>
            <ecNumber evidence="15">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">FG02079.1</name>
        <name evidence="21" type="ORF">FGRAMPH1_01T05013</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="22">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="23">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="22">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="21 23" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="21">PH-1</strain>
        </source>
    </reference>
    <reference evidence="22" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in vacuolar sorting and osmoregulation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="15"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317954.1">
        <property type="nucleotide sequence ID" value="XM_011319652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1REJ0"/>
    <dbReference type="FunCoup" id="I1REJ0">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1REJ0"/>
    <dbReference type="EnsemblFungi" id="CEF74313">
        <property type="protein sequence ID" value="CEF74313"/>
        <property type="gene ID" value="FGRRES_02079"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02079"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05013"/>
    <dbReference type="eggNOG" id="KOG2194">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006412_1_0_1"/>
    <dbReference type="InParanoid" id="I1REJ0"/>
    <dbReference type="OrthoDB" id="76293at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053975">
        <property type="entry name" value="PFF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053976">
        <property type="entry name" value="PFF1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF58">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22250">
        <property type="entry name" value="PFF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22251">
        <property type="entry name" value="PFF1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="10 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="709"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="745"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="776"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="18">
        <location>
            <begin position="198"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease transmembrane" evidence="20">
        <location>
            <begin position="480"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease C-terminal" evidence="19">
        <location>
            <begin position="802"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="615"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="615"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF22251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CEF74313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1033" mass="115286" checksum="8015FCA90EEC34B9" modified="2012-06-13" version="1">MRAKNPLAFRPGPVTFWTTVIYIALFIPLIWVHETVPAAPADRSLYQGLNLTEAWFDLQAISSTYHPYNSHENDRVRQFLIDRTKEILDRNDLSYTTESIGGVDWYSRTSSFGNPNSVDTPQETVQAKPRGATLFDDRTSNVSWTYNTARRMGSNISKGTWLGQYFEGNNYYVYIHGTDDPEGEWWRDESKYKKFHGQGGVLVNCHFDSVSTGYGATDDGMSCVSMLQLLSYFTLKGRQPKNGIVLLFNNAEEDGLLGARAFGYSPLLHFTHTFVNLEGAGAGGRALLFRTTDLQAAKAYSKSPHPLGSVVAANAFERGVIKSATDYEIFADIFGQRGLDIAFYAPRARYHTNQDDARHTSVNSIWHMLSAALASTEHLSKTTGTIFNGDRSDGNSDLVQNGKQAEGVWFDIFGAAWAVFALRGLFAWSLTLLVATPLVLMAFTYILVRNDKYYFFARDIKMHHDINDDPVTLGGWKGFFRFPFALAFAGGLTIAATLLVAKFNPLIIYSSGYAVWSMTLSIFYFSFWLIMRGSAFVRPSALHRGFVLIWLFALGWGVQVVCAVAEDRMHIGALYATVFFQSAIFLALLISLLEQFALLSKHDFALQLHDAHQARDVSSRGTEQESRHQPENEPAQAEADDGEDEDGDATETTPLRAGESGYGSNAQTSFANTYRRSVADTSPAPPSMRRYQPFEHEQSWSGRLPTWTWILQFLFLAPIPVIMFGNLGLVVMTATQMTGTDGGSLLVPVLSLGILSIFLLLPLTPFMHRVTHHVPMFLFFVFIGTLIYNLVAFPFSDNNRFKFYFQQVIDLDNGTDTVSIVGIEEYARSVINSLPSTTGQQIKCQPAVGRDLTDCQYDSSSLTPNLYKDKSPKQLVSIETVDGSNGSRARLRIDAVDSRLCYVRTSRPIYGFAVDGASARDPRFGKFPSEGFSSVQLWRRDRDRPWTLNLYLNERNALALTESEQEESEMLVAKARSVEQAAGLEVTVSCAWSDANTPGTIPALDELLKYMPTWAAVTKKNVGLVEVRKTHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RFK0</accession>
    <name>I1RFK0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG02479.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T05949</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318407.1">
        <property type="nucleotide sequence ID" value="XM_011320105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RFK0"/>
    <dbReference type="FunCoup" id="I1RFK0">
        <property type="interactions" value="466"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RFK0"/>
    <dbReference type="EnsemblFungi" id="CEF74779">
        <property type="protein sequence ID" value="CEF74779"/>
        <property type="gene ID" value="FGRRES_02479"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02479"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05949"/>
    <dbReference type="eggNOG" id="KOG0094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="InParanoid" id="I1RFK0"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000229">
        <property type="entry name" value="Probable Ras-related protein Rab-6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF74779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="208" mass="23339" checksum="1D05B081D365BC2C" modified="2012-06-13" version="1">MAQAGGSYNNPLKKFKLVFLGEQSVGKTSLITRFMYDSFDNMYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSSVAVVVYDISNAKSFQNTKKWIDDVRAERGNDVIIVLVGNKTDLNEKREVTTQQGEEEAKKNNLMFVETSAKLGHNVKNLFKRIAQALPGMEGSDAAAQASNQMIDVKTNNTQQSQEGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RG27</accession>
    <name>I1RG27_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG02676.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T06413</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318627.1">
        <property type="nucleotide sequence ID" value="XM_011320325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RG27"/>
    <dbReference type="EnsemblFungi" id="CEF75011">
        <property type="protein sequence ID" value="CEF75011"/>
        <property type="gene ID" value="FGRRES_02676"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02676"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06413"/>
    <dbReference type="eggNOG" id="ENOG502SI0U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020030_3_1_1"/>
    <dbReference type="InParanoid" id="I1RG27"/>
    <dbReference type="OrthoDB" id="5380854at2759"/>
    <dbReference type="PHI-base" id="PHI:1442"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF51">
        <property type="entry name" value="ACRIFLAVINE SENSITIVITY CONTROL PROTEIN ACR-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF75011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="551" mass="61443" checksum="B35EB53A7F22E770" modified="2012-06-13" version="1">MSSSPPDSETITASNAPVAKKACHSCRRARLRCDKSIPHCSKCTSRGVECLGYGRLFLWTGSVATRGKLAGQSSSASVCRLPKQGEAQITEVSPEMPDMQMDSFDAQGVEPGSWALAPSQENQLVLQDKTQPWSPPSPSSPTSPSSPWTLCDPLFQDMTHSQRWYLNYYSTRVSMDLVGDEQTKSNRNPYLNLLQLTNEHAFLQQIIIAVSAAHMCNLSRPWLGPNSYTRKEAPKKLLMDALVAKQKGLQMMPEALRNIETIGADVILATVLFLINSELIESGWQSWRPHLEGAKKLLNMTEPFASSDTTLRDYIVADCYVYCTLSLSFNPSTPGTQALSFAPDQVKATLARTDNSFFCCPPEVLDILRETAQLLHSESQGGVSSQGALMEFTNLLDRAQRLDVLKWAKDRVPDSNEVALWSSCRTGSAHRLATCLYIIQSAPALRTRMPDQVCKSLIQDLYDTLLPLPDEDPNFKATGWPTFIYGTTVRTPESRAWVMDRLKMVAAICPWGFLYSAIDTLQILWKNDTESEGYMNWVQKLKDLNVDFLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1RGE9</accession>
    <name>I1RGE9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG02809.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T11365</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323003.1">
        <property type="nucleotide sequence ID" value="XM_011324701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RGE9"/>
    <dbReference type="STRING" id="229533.I1RGE9"/>
    <dbReference type="EnsemblFungi" id="CEF77485">
        <property type="protein sequence ID" value="CEF77485"/>
        <property type="gene ID" value="FGRRES_02809"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02809"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11365"/>
    <dbReference type="eggNOG" id="ENOG502SC31">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048152_0_0_1"/>
    <dbReference type="InParanoid" id="I1RGE9"/>
    <dbReference type="OrthoDB" id="5318346at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF1">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="78"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF77485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="292" mass="33059" checksum="F6C2A2C8A4E0D6D3" modified="2012-06-13" version="1">MSSPKDSQEWTQVSRKSRKNKSKSTSSNQVPSSSRSHINARREVPNKENIRTPAELEASYRQNREHWESEPSCAEVRELIASKASHLNKINRAINFGVGTFDPKGVYNPKASFVQLAAFDVIVEELEKITGEKIETYIQDPLFSGSDKTFLGNLGHTVVEEPAGNDLITPTTFFFGVHLYKGVYKDAFEKHLPVLFIGTSWDAWENTLDVDGLEKIKEIHNTFEHCEFPEDKYDTAFSTTGIYWKVNGEDEKSESVEDEDKDKVKEKDERNGVAVKGDEDELSKKLESTTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RGL9</accession>
    <name>I1RGL9_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Cutinase</fullName>
            <ecNumber evidence="3 13">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">FG02890.1</name>
        <name evidence="14" type="ORF">FGRAMPH1_01T11549</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cutinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3 13"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322914.1">
        <property type="nucleotide sequence ID" value="XM_011324612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RGL9"/>
    <dbReference type="ESTHER" id="gibze-i1rgl9">
        <property type="family name" value="Cutinase"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF77578">
        <property type="protein sequence ID" value="CEF77578"/>
        <property type="gene ID" value="FGRRES_02890"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02890"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11549"/>
    <dbReference type="eggNOG" id="ENOG502SI38">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040058_2_0_1"/>
    <dbReference type="InParanoid" id="I1RGL9"/>
    <dbReference type="OrthoDB" id="3225429at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000235">
        <property type="entry name" value="Cutinase 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
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    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
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    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043579">
        <property type="entry name" value="CUTINASE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF3">
        <property type="entry name" value="CUTINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00931">
        <property type="entry name" value="CUTINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 13" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009997683" description="Cutinase" evidence="13">
        <location>
            <begin position="17"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
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            <position position="204"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="47"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="187"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CEF77578.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF77578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="227" mass="23525" checksum="9F57BE86176C1595" modified="2012-06-13" version="1">MKFSAILSFLAASSAALPTSNSFVALEGRQAGSITRNDLSSGASSACPPVIFIYARGSTELGNLGTLGPRVASALESYYGRDKVWIQGVGGAYDATIGDNLLPRGTSAAAIREMIALFNLANSKCPSAKVVAGGYSQGAALAAASIEDLSTSVRDKVVGTVLFGYTKNLQNLGRIPNYPRERTKVFCNIGDLVCTGSLIVAAPHLAYQSDASGPAPEFLIQRVAASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I1RGY5</accession>
    <name>I1RGY5_GIBZE</name>
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        <recommendedName>
            <fullName evidence="14">Crh-like protein</fullName>
            <ecNumber evidence="14">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">FG03017.1</name>
        <name evidence="20" type="ORF">FGRAMPH1_01T11857</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="21">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="22">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="21">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="20 22" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="20">PH-1</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="14"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322771.1">
        <property type="nucleotide sequence ID" value="XM_011324469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RGY5"/>
    <dbReference type="STRING" id="229533.I1RGY5"/>
    <dbReference type="EnsemblFungi" id="CEF77731">
        <property type="protein sequence ID" value="CEF77731"/>
        <property type="gene ID" value="FGRRES_03017"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03017"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11857"/>
    <dbReference type="eggNOG" id="ENOG502QQ71">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027506_3_2_1"/>
    <dbReference type="InParanoid" id="I1RGY5"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF27">
        <property type="entry name" value="GLYCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124163" description="Crh-like protein" evidence="18">
        <location>
            <begin position="21"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="19">
        <location>
            <begin position="42"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="261"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="15">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CEF77731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="385" mass="41401" checksum="DE29FD39C371ECF9" modified="2012-06-13" version="1">MVSAWSKIAMAASLAASVTAQTYTSCNPMKKSCDPDVGLAASSYTVDFTKGADDDNWEGTGHGDVKYTSDGAEFTIDKEGQSPTIQTKWHMFFGRLEVHLKAAPGQGIVSSIVFLSDVLDEIDWEFLGGRPNEAQSNWYAKASTDNTQSLTFPVDNAQADFHNYTVHWTSESIEWYIDSTKVRTLAYPSGGVNYPQTPMRIKLGIWAGGDPTNAEGTIEWAGGETQYQDAPFTMTVQKVMVQNLNPADSYTYGDETGSYKSIKFDKKDNGSDDEDKDEDKDETESTTASTTASKTDSKTTESATETATATDSDSESTTMSTARSSETGSSDFKNNKAEETSGSETGTSTGSSASSTAKSDENSASGNMPKMWLSLGVLCGAMLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1RHD9</accession>
    <name>I1RHD9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG03186.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T12259</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322578.1">
        <property type="nucleotide sequence ID" value="XM_011324276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RHD9"/>
    <dbReference type="STRING" id="229533.I1RHD9"/>
    <dbReference type="EnsemblFungi" id="CEF77933">
        <property type="protein sequence ID" value="CEF77933"/>
        <property type="gene ID" value="FGRRES_03186"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03186"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12259"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_6_1"/>
    <dbReference type="InParanoid" id="I1RHD9"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05370">
        <property type="entry name" value="SDR_c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF77933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="261" mass="28961" checksum="F6DDE0E5AFE9B1E1" modified="2012-06-13" version="1">MTQDALAFQCAVVTGGGGGIGRALAEYLISKGKKVLIAGRTESNLQSTVKEIGAAGYYVLDTGKTSDVPAFVKKITSEHPELDCLINNAGVQRPIEVLKNDDFLEKADQEIDINIRGPMHLALNLIPHFKEKPNALIMNVSSVLGFIPFSIINPVYNGTKAWLHFWSMNLRTQLKDTNIRVVELAPPMVATDLHRERENPDDNKKEYSPQTLTVKEFMDEITPKFERGDETISAGMGAGAIDKWFETFGERYEGAEKGYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1RIU7</accession>
    <accession>A0A098DKW9</accession>
    <name>I1RIU7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG03742.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T13597</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321949.1">
        <property type="nucleotide sequence ID" value="XM_011323647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RIU7"/>
    <dbReference type="STRING" id="229533.I1RIU7"/>
    <dbReference type="EnsemblFungi" id="CEF78601">
        <property type="protein sequence ID" value="CEF78601"/>
        <property type="gene ID" value="FGRRES_03742"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03742"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13597"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011025_0_0_1"/>
    <dbReference type="InParanoid" id="I1RIU7"/>
    <dbReference type="OrthoDB" id="413885at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.10">
        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF4">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124294" evidence="4">
        <location>
            <begin position="20"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="746"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="751"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="784"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF78601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="804" mass="84370" checksum="8C0D035AA3F840F9" modified="2012-06-13" version="1">MRFSTIFSSAALMFQAVSAASEEYKDADTGITFQQFVDKSSKFSFGIAMPEKPSTDFIGQIIAPISEGYASVGMGSTMSKKLLIVAWPNDGKVVTSVRQASGYTNPDVLDDDTVKIKPIEKGVKVGADSFTFTFLCEGCIKTDGTTFKAADANAVMAFAFSTTALDDPTDASGALNYHGAGFGGFSVDAGSSKSADYETWAAMASDGAAAPGSGSGGSAPPAGNFTTVVSNMTYDYIVVGGGPAGIIVAERLLESKKSVLLVEGGKASYYSTGGKAVMDWNETTTQYDVPSMAYHLTTSKVDTSEYCTDTASMAGCLLGGSTAVNAMMFVRPQSVDFDDKWPAGWKSTDVEAAASRLWERTPGTLSPTKDGKLVDQAAYNVLSQFFSGNGFSQVDAIAQPNKKKAVFTHPPMMITNGQRAGPVRDYLPIAQANSNFKLMLESKVMRVVREGKEITGVEIQSGPATRQIIKVKTGGAVVLAAGALSTPRLLVNSGIGPAKQIETVASGSQRLTMPPKDQWIDLPVGKNLKDHPIFTVKVKTKSPMAALPDTAFTEPSQENVDLYAQGNGLLAQSGQRFIFWDSVMGSDGVERYVQGTCAPAGDDALKLKVYLTHGSTSSGALEVTSSGATKLIGEPYLNDAADKAAVKTFMQKLIDMASKPNSTIIIPSNATAESLMSSYVSGSHFVGSAIMGTENDGSSVVGTDTKVWGTDNLYVVDASIHPDLPTGNTQAIVMVAAEHAASKILNGGSGSSSPVVPPTVGSGSGSDSGSSPVETPVATPVKKPGSKCRRSLRQRQRRRLQRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1RIV5</accession>
    <accession>A0A098DI31</accession>
    <name>I1RIV5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG03750.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T13623</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321939.1">
        <property type="nucleotide sequence ID" value="XM_011323637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RIV5"/>
    <dbReference type="EnsemblFungi" id="CEF78614">
        <property type="protein sequence ID" value="CEF78614"/>
        <property type="gene ID" value="FGRRES_03750"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03750"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13623"/>
    <dbReference type="eggNOG" id="ENOG502T5XR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_340664_0_0_1"/>
    <dbReference type="InParanoid" id="I1RIV5"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124225" evidence="8">
        <location>
            <begin position="21"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="253"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="368"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="484"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="585"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="693"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="693"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF78614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="787" mass="87451" checksum="85EB91BF28F79D2E" modified="2012-06-13" version="1">MARLIFVYAALFFWVTLAVAQYDHNNLLKGCYQGRSDDFTLGGFARTQPQRERCALVCSQRGNTFVAFGTVHCFCAKSEPPSTNEVDITRCKAHGLDGWNAPKLGKANHIEEVFVVFNIDPKRKSDNSKSSSQDEAKLSPHSGSPAGLAPSAGPSKPLGCYPGLPIDVHLTKITITEDERRECAKSCGGEGKAAVVFSGLKCGCTNILPDASTRVEDIRCALQSTNKLYRTDLVYSVWSTGVEAQEKSTSLIKGPVGKCFSSRPLTSRQFIVRNNGHVREVCLDRCNYHGYPIALVHDSNCWCAKTYPRRIYSSGLESCDIPCLGDNGGRCGGTKGIKLYYSVYETEQVDKAPVDLSRRPFDLPVRHETTWHGCWSEPPITEHHSLSIQNNTPASCASYCRRYKSKVAAVRQNSCICAESYPERSRRRPDSLCKSSCPGNPYEDCGGTQVWTVVNTGLDTRVSFDKPRLKEQPEDFNMNPGSKKASLSGCYAEESVTQGAIQVHIGGGRVELCASRCRNLKMPVSALQGKTCVCRDTIPRKDSKVDKFHCNHSCRDADEGSCGGKDTYSIYNSGLQGHIRIDANTKQSHGCFRFDRFLSTRRTPELVRVDIHGPNRNPKGGSCTTQCAEKGFAVALRHHTQCFCSPGLPQERRRVDDEFCSIGCRGDTLETCGGPSYAYTVYKTDAYMPDLHTEKKPKAKKPKQEDLSPSPDSRPQCLHPALDKVYEVFNEVSDRMAVITQKVRHGFFWLRDKSQHIFDVCLWHVMLFFSNIMYRLGLLSAEGVVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJP7</accession>
    <name>I1RJP7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG04077.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T14417</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321566.1">
        <property type="nucleotide sequence ID" value="XM_011323264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJP7"/>
    <dbReference type="SMR" id="I1RJP7"/>
    <dbReference type="ESTHER" id="gibze-i1rjp7">
        <property type="family name" value="Acetylxylan_esterase"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF79011">
        <property type="protein sequence ID" value="CEF79011"/>
        <property type="gene ID" value="FGRRES_04077"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04077"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14417"/>
    <dbReference type="eggNOG" id="ENOG502SQ4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040058_4_0_1"/>
    <dbReference type="InParanoid" id="I1RJP7"/>
    <dbReference type="OrthoDB" id="2586582at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF9">
        <property type="entry name" value="CUTINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124343" evidence="4">
        <location>
            <begin position="18"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="227"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF79011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="282" mass="29963" checksum="DD5286DE73A9200E" modified="2012-06-13" version="1">MRPFVLSTAVLVTGAVAQNAWKTCYDGLFMIAARGTNEEKGSGRIGEIAEAVAKRINGSHVYGLDYPASFQDPAYEDSESDGVKKLKDILSSYFYQCPKNKVAVFGYSQGGQVASDVFCGGSGGDFPTNKPLTVNDVEKNVVAIITFGDPSHVANVSYDLGSSINDGIFQRNDTKLCEDKYSGILHAYCDTGDVYCDRGDDTDVHKSYFEKYGKKVEDLVVEKYESAMSESTTTPTADATSSVTSAASEVTSTDAPGNGASGLVPGLVLSMVPLALGLSQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1RK19</accession>
    <name>I1RK19_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG04207.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T14737</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321419.1">
        <property type="nucleotide sequence ID" value="XM_011323117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RK19"/>
    <dbReference type="STRING" id="229533.I1RK19"/>
    <dbReference type="EnsemblFungi" id="CEF79170">
        <property type="protein sequence ID" value="CEF79170"/>
        <property type="gene ID" value="FGRRES_04207"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04207"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14737"/>
    <dbReference type="eggNOG" id="ENOG502S756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083991_0_0_1"/>
    <dbReference type="InParanoid" id="I1RK19"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014:SF10">
        <property type="entry name" value="RICH PROTEIN MS8, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF79170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="204" mass="21497" checksum="DA59BCE9236E8DA8" modified="2012-06-13" version="1">MSANDYYGNSNSGYGQQGGYPQQQSYGQPQYGQQSGYPQQQQYSQPQYSQHQQPQSYGGYNQQQPQYSSHNQQPSYNSHSPVPQQGYGQQHGSSPYPPQHQDNSQHGAPAYPQQGGAPGQYPPGQPGPDGERGLGATLAGGGAAGWAAHTAGSGLLGSLGAAAAGAIGANLLENKFKKNKKNKKDKKHKKRGINGSSSSSSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1RKD7</accession>
    <name>I1RKD7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG04339.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T15049</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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        <property type="protein sequence ID" value="CEF79325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblFungi" id="CEF79325">
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        <property type="gene ID" value="FGRRES_04339"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04339"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15049"/>
    <dbReference type="eggNOG" id="ENOG502RZ40">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_005193_1_0_1"/>
    <dbReference type="InParanoid" id="I1RKD7"/>
    <dbReference type="OrthoDB" id="2290221at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Bit61/PRR5"/>
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        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
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        <property type="entry name" value="HbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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        <source>
            <dbReference type="EMBL" id="CEF79325.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF79325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="847" mass="91126" checksum="91BF364AC17565F8" modified="2012-06-13" version="1">MQPSRSQPRGPGSFNPLSSSSAQPSQLSTSSSRPALRRVETSDGEDETPRPSITIPKSRQPSQPQPSSPATPIYAQFTTHGNSSTASLGHHNFSRPANSRSVTQGSPATLVKGHARKHSATQGSFEPTLPSMSTSNLSSHLGMSHQNPSNTSMSAAAAAAAAASASNASLSASQMAAQAAVMSHQNHSRQRSQTVPFPGDPNDGVRRGSGSKGPTSPPMLSLTEASAPRDTGFVNHGGYGGPHSSAATAAANVVFPRSGHTSPRVSPQPYSQPPAPPPPVSEKPNKIEKSKVKLFSRPGKISTKGESKEKPLPSPGKIGSALSALQRGNFSTNSLVDPSNQSIYNLNNSSSATIRPIETPTEEREKDKEKGKEKEKKHHFLSRQKHKLKDEYHLPLSSAASNSRPTDPNAPNPLYNFNIPPSPAPTSSTFAKAKKDKKLAERSDSRLDGESSFNGQSEWPGPSSLPSLSQQSTMYDPIDPGKLGLHNHMSLDDAWPYLRAKLLVIFEGEDLRLPIEDFNRVVQMHIQWCMHRRSPNTMLEDLRDLLHTGFLSLDRTLRQTPEDRFIPTLVELWMFTFTSILPYMQAVFLPLDLEVSGCGTLMTGEQARDFWGGAIASSFGSGGPARVAPAPSVLDVRRLVLIAYRDTVILPRYDTLKTIFSRLSLEFLPSSLASIAMSSTPEAALSTSPSESFGRPGTAMSLDPSNASYNSTSTTLLGEGSAGGRSRAISNVSFGSHGSDGGLRPFTPSGSERIPPVPSLGSLREREQNVEDSKHITEMVGRMLQCMSVLSGVSAGDVGAEGNERVVELCKMLKLNWLGRGRTGRNRRGMVGGRVRREDMRDEVRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1RLV2</accession>
    <name>I1RLV2_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="3" type="primary">FG04921.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T16645</name>
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    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323392.1">
        <property type="nucleotide sequence ID" value="XM_011325090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RLV2"/>
    <dbReference type="EnsemblFungi" id="CEF87573">
        <property type="protein sequence ID" value="CEF87573"/>
        <property type="gene ID" value="FGRRES_04921"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04921"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16645"/>
    <dbReference type="eggNOG" id="ENOG502RP19">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1570787_0_0_1"/>
    <dbReference type="InParanoid" id="I1RLV2"/>
    <dbReference type="OrthoDB" id="5128796at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
            <begin position="13"/>
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        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF87573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="165" mass="18165" checksum="32199CFDE0017A1C" modified="2012-06-13" version="1">MASIMEKIKETVVPSNNEGYSNNPSSYDNEPPSYESSHSNNNSGIYNSVTENNAQREFSSNNAAPLESTSTHNEGVRTGDQINSLVENIPGVSSSNQNKSTSDMPSYQNNMHRDTTSDTPFDAARAPPSALKKHLGEPTIEHDYPHDSSTKRHASVSHQEEHYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I1RN60</accession>
    <name>I1RN60_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
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        <name evidence="4" type="primary">FG05424.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T17883</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323960.1">
        <property type="nucleotide sequence ID" value="XM_011325658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RN60"/>
    <dbReference type="STRING" id="229533.I1RN60"/>
    <dbReference type="EnsemblFungi" id="CEF88215">
        <property type="protein sequence ID" value="CEF88215"/>
        <property type="gene ID" value="FGRRES_05424"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05424"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17883"/>
    <dbReference type="eggNOG" id="KOG0707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2491">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017925_0_0_1"/>
    <dbReference type="InParanoid" id="I1RN60"/>
    <dbReference type="OrthoDB" id="10257415at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265:SF0">
        <property type="entry name" value="HPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11957">
        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="2">
        <location>
            <begin position="605"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF88215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="826" mass="92626" checksum="172945C3E4E03D83" modified="2012-06-13" version="1">MAVQDTDNPAAPAISAFTILLDDLLSQAERSKQSATIEPALRKSDFDDLSGRITTTAAEVASPADESAKPANDKGQQFAIIETAARNIFSHLIATTTIDSPDYVKVWNLLDILSILSDDGQCDPALLFWLAEELLDSQTIAGCRKIFDFLESRRERITANHFKQKQLIILRTCNELLRRLSRAEDTAFCGRVFIFMFQSFPLGDKSSVNLRGEYHVENITTYEQGTADDDFRMALDGPDEQPKELSESKTTPKSTDAKKEDKEKPLPTDVLYPLFWSLQEYFSQPKKLFETTSLSSFKESLAATMNVFQTVHNDSKRSLKRKRETGEEDESFNTFNPKYLTSKDLFDLEISDLSFRRHILVQALIIMDFLLALSKLSRDKLTETLPATAIINKAVMYGDQVLIEEDAKWASDTKRTIADYLRQGPDGPYFYRMVETVLARDKNWVRWKIEGCQPIKRDPVAPPVFVEAKGNVQRLATSKRLRAVPMGSVSLDFLREEDAEAAMGRLKAKERYELPELDAFKRKIADDDFEIEMPTNDQTKAAAVSGKASKSWRALRIAARTKLAAFDKIEDPKKIDIVFEELTEADDEGDAAEPTASDEDMPTTREPIIVSGITGVGCSAIINKLMEERKGVFATVVRHTTREPLDGEVNGKTFHFVKQQEFNQLRDGDRLIESGTRNGVDYGTSSKAIEAITETGKVPIIELDIEAAQYAKDMGFEARYVLIKASTPEVLEQRLKALGKEDSTIQEILKRLPTELEPEKADELFNATIVDDDEQAAVKILDDYVYAKSEDEPTAEPGSGEDTAMKEDDEAIAEDTETKEATMTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I1RNW0</accession>
    <name>I1RNW0_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Catabolic 3-dehydroquinase</fullName>
            <shortName evidence="3">cDHQase</shortName>
            <ecNumber evidence="3">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-dehydroquinate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG05702.1</name>
        <name evidence="3" type="synonym">qutE</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T18551</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis; 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homododecamer. Adopts a ring-like structure, composed of an arrangement of two hexameric rings stacked on top of one another.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="3"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324278.1">
        <property type="nucleotide sequence ID" value="XM_011325976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RNW0"/>
    <dbReference type="STRING" id="229533.I1RNW0"/>
    <dbReference type="EnsemblFungi" id="CEF86290">
        <property type="protein sequence ID" value="CEF86290"/>
        <property type="gene ID" value="FGRRES_05702"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05702"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18551"/>
    <dbReference type="eggNOG" id="ENOG502S1A9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090968_1_0_1"/>
    <dbReference type="InParanoid" id="I1RNW0"/>
    <dbReference type="OrthoDB" id="8191625at2759"/>
    <dbReference type="UniPathway" id="UPA00088">
        <property type="reaction ID" value="UER00178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046279">
        <property type="term" value="P:3,4-dihydroxybenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019631">
        <property type="term" value="P:quinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="entry name" value="Dehydroquinase, class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003804">
        <property type="entry name" value="PRK05395.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003805">
        <property type="entry name" value="PRK05395.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003806">
        <property type="entry name" value="PRK05395.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003807">
        <property type="entry name" value="PRK05395.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272:SF3">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="Type II 3-dehydroquinate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 3" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3 4">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <begin position="102"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3 6">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF86290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="150" mass="16361" checksum="C758C340E23B2544" modified="2012-06-13" version="1">MSRRLLLLNGPNLNLLGTREPHLYGSTTLKDVENDAINQASGLSATIETFQANSEGAIVDRIHEARGNIDAIIINAGAYTHTSVAIRDALVGVDIPFVEVHVTNVHAREKFRHHSYLCDKAEAVICGLGVFGYTAAIEYAAKHLKLRTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>I1RPP5</accession>
    <name>I1RPP5_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">FG06021.1</name>
        <name evidence="17" type="ORF">FGRAMPH1_01T19307</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324640.1">
        <property type="nucleotide sequence ID" value="XM_011326338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RPP5"/>
    <dbReference type="FunCoup" id="I1RPP5">
        <property type="interactions" value="981"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RPP5"/>
    <dbReference type="EnsemblFungi" id="CEF86929">
        <property type="protein sequence ID" value="CEF86929"/>
        <property type="gene ID" value="FGRRES_06021"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06021"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19307"/>
    <dbReference type="eggNOG" id="KOG0749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_12_0_1"/>
    <dbReference type="InParanoid" id="I1RPP5"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
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        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
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            <begin position="116"/>
            <end position="139"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="16">
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            <end position="200"/>
        </location>
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            <begin position="220"/>
            <end position="241"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF86929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86929"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="311" mass="33710" checksum="06FBDB2F2FF0A192" modified="2012-06-13" version="1">MSSAEPQKVLGMPPFVADFLMGGVSAAVSKTAAAPIERVKLLIQNQDEMLKTGRLDRKYNGIGDCFKRTMADEGVMSLWRGNTANVIRYFPTQALNFAFRDKFKKMFGYKKDKDGYAMWMAGNLASGGAAGATSLLFVYSLDYARTRLANDAKNAKSGGDRQFNGLVDVYKKTLASDGIAGLYRGFMPSVAGIVVYRGLYFGMYDSIKPVVLTGNLQGNFLASFALGWIVTTGAGIASYPLDTIRRRMMMTSGEAVKYKNTMDAARQIVAKEGVKSLFKGAGANILRGVAGAGVLSIYDQLQVLLFGKAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQB2</accession>
    <accession>A0A098DWD2</accession>
    <name>I1RQB2_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG06253.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T19871</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324901.1">
        <property type="nucleotide sequence ID" value="XM_011326599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQB2"/>
    <dbReference type="STRING" id="229533.I1RQB2"/>
    <dbReference type="EnsemblFungi" id="CEF86136">
        <property type="protein sequence ID" value="CEF86136"/>
        <property type="gene ID" value="FGRRES_06253"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06253"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19871"/>
    <dbReference type="eggNOG" id="ENOG502R9U6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124007_1_0_1"/>
    <dbReference type="InParanoid" id="I1RQB2"/>
    <dbReference type="OrthoDB" id="4777826at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF86136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="134" mass="14527" checksum="B39E36906EAC3A34" modified="2012-06-13" version="1">MKPNKAILTSVADKMRTKGYTYSFDAINQHVQKLRKNRDTAAIQNAGSDTATPRKARATAPKTPKRAPKRKAPAKSASIADDDEDLEDMKMQLKMEDADADDGDLLSPKGAKRARNVTPKAEPDADDEGDSGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQN0</accession>
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    <name>I1RQN0_GIBZE</name>
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        <submittedName>
            <fullName evidence="5">Chromosome 3, complete genome</fullName>
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        <name evidence="6" type="primary">FG06376.1</name>
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    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325038.1">
        <property type="nucleotide sequence ID" value="XM_011326736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQN0"/>
    <dbReference type="FunCoup" id="I1RQN0">
        <property type="interactions" value="448"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RQN0"/>
    <dbReference type="EnsemblFungi" id="CEF86897">
        <property type="protein sequence ID" value="CEF86897"/>
        <property type="gene ID" value="FGRRES_06376"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06376"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20161"/>
    <dbReference type="eggNOG" id="KOG3139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_0_3_1"/>
    <dbReference type="InParanoid" id="I1RQN0"/>
    <dbReference type="OrthoDB" id="249099at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="13"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF86897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="186" mass="21114" checksum="E758A99EC024AB4D" modified="2012-06-13" version="1">MATTKTENLPGELRYVQYEHALEAQYLPAIRALISKDLSEPYSIYVYRYFLCQWAHLCFMALNPVDSSLIGVIVCKLEIHASHSNPTRRGYIAMLAVASDFRGHGIATTLVKKAIDAMTKRNADEIALETEETNVAAMRLYEQLGFLRTKKLHRYYLNGNSAYRLVLPLKYIDLDAGPNDLEIINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQN8</accession>
    <name>I1RQN8_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein transport protein SEC24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein transport protein sec24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">FG06384.1</name>
        <name evidence="22" type="ORF">FGRAMPH1_01T20179</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="23">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="24">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="23">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="22 24" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="22">PH-1</strain>
        </source>
    </reference>
    <reference evidence="23" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325046.1">
        <property type="nucleotide sequence ID" value="XM_011326744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQN8"/>
    <dbReference type="FunCoup" id="I1RQN8">
        <property type="interactions" value="875"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RQN8"/>
    <dbReference type="EnsemblFungi" id="CEF87957">
        <property type="protein sequence ID" value="CEF87957"/>
        <property type="gene ID" value="FGRRES_06384_M"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06384"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20179"/>
    <dbReference type="eggNOG" id="KOG1985">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004589_2_1_1"/>
    <dbReference type="InParanoid" id="I1RQN8"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990753">
        <property type="term" value="C:equatorial cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
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        <property type="entry name" value="Sec23/24_trunk_dom"/>
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    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
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    </dbReference>
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        <property type="entry name" value="Helical domain of Sec23/24"/>
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    </dbReference>
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        <property type="entry name" value="vWA-like"/>
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    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="18">
        <location>
            <begin position="265"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="19">
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            <begin position="339"/>
            <end position="580"/>
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    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="21">
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            <begin position="586"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="20">
        <location>
            <begin position="680"/>
            <end position="781"/>
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    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="17">
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            <begin position="809"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
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    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CEF87957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="944" mass="103250" checksum="C184EEA09BE065CF" modified="2012-06-13" version="1">MSMPPPGEGFGGYPAQPHDQYAAQDEQPQQSYEDPAAAQQPHDQGHKKKKRGYAAQAFEVGTGANAVAGGQPTGAAQQFGAAPVQPGYGGYQAEPQAAAPQGYQYPQGYGAQQPAAAQAPQYGYQAPDQGYPTPGAQQPAPGVGGITQGIGSMNIAGQPQQPQNAQAPRPAVLNQLYPTDLLSQPFNVSELDLPPPPIVLPPNTSVTPSPDANCSPRYFRSTLNAVPTTNSLLKKSKLPLALVIQPYGSLHDDEDPVPVVQDQVISRCRRCRTYINPYVAFLDQGHRWRCNMCNLTNDVPQAFDWDAAAQQSVDRWQRPELNHAVVEFVAPQEYMVRPPQPLIYLFCFDVSYAAVSTGLVATAARTILDSLDRIPNADRRTRLGFLAVDSSLHYFSVPKDTDENGETNMLVVSDLEEPFLPIPNDLLVPLTESRQSVEKFLQKLPDMFQNNQSNGSCMGSALRAAHKLISTLGGKIVVLTASLPNMGVGKLEMREDKKLLGTSKEGGLLQTANSFYKSFAVECSKSQVSIDMFLFSSQYQDVASLSNLPRYTGGQTWFYPGWHASRPEDALKFASEFSDYLSSEIGLEAVLRVRATSGLRMNTFYGNFFNRSSDLCAFPAFPRDQCYVVEVAIDENLTKNVVCLQAAVLHTTCNGERRIRVMTLALPTTTNLSDMYASADQCAITTYFSHKAVERSLSSGLDAARDALQSKVTELLQTFKKELAGGSMGGGLQFPANLRGLPLLFLGLIKNVGLRKSSQIPSDIRSAALCLLSTLPVPLLMRYIYPRLYSLHDMPDNAGVPEQETGHIALPPALNLSSERLVPYGLYLIDDGQTQFLWIGRDAVPQLVHDVFGVEDRTQVQVGKGRVPELEGDFNERVRAVVQKSRDHKSLGVGSITLPHLYIVREDGEPSLKLWAQTLLVEDRADQGVSAAQWLGMLREKVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQZ2</accession>
    <name>I1RQZ2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG06494.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T22433</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326103.1">
        <property type="nucleotide sequence ID" value="XM_011327801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQZ2"/>
    <dbReference type="STRING" id="229533.I1RQZ2"/>
    <dbReference type="EnsemblFungi" id="CEF85297">
        <property type="protein sequence ID" value="CEF85297"/>
        <property type="gene ID" value="FGRRES_06494"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06494"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22433"/>
    <dbReference type="eggNOG" id="ENOG502S495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015886_0_0_1"/>
    <dbReference type="InParanoid" id="I1RQZ2"/>
    <dbReference type="OrthoDB" id="5206661at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF85297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="610" mass="67898" checksum="D752D4501AE65D3B" modified="2012-06-13" version="1">MSSRGVPEVLFKKVDEYVDSLAPQIQPRITTELETFQQKTIDSLEDKVVDAFRSLFDKDKKPSDSRSLDDNAPDAYGGQSLPFADEIAKLTRSFTKITDEAGDDLRDIFDITEGRGGGGDETRSRGGGDSSRGGAKGFLSFAIDAVQDHLENNSGKGSGGPGFELDGLLGVLSGTVKDAARNPEEKARLISPEIKEQVGAKLREQHAPIAEQFTRIALDHIKRWLRGNTSTRDLGDGVKGEIEDQVKDLVKGLGGLFGNKKSNEGSARGFGDNDRDGERADGDGESGGFSKVISDKLSTGIARVHREVRLEFRKILGGIEKQLFELLPDSFQRPLEKILGGNPFDSQLDRDAGGSADRGFGDDIKAKLVNKIRGLVRKVQETLRESILGVVNGGHRKFERQSWVFVQNMVEQKVQKYLPKVKISVPDDIGNEGVSVGAPAAGNLGGANHPVPAEQGGQYGQQPYNPPSQFQQDHRPEHQGQDYRPQSQEYRPQGHDEYRPQQGQDYRPHDSQEYRPQQSQEYRPQGHDEYRPQHGQDYRPQHQEGYRPDEYRPQQHQSQQDYRPDQYPPPPQQHQSGGYNQGYQQDQGYGQNRGGYDQGQDQGYGNNPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1RR18</accession>
    <accession>A0A098DSD1</accession>
    <name>I1RR18_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG06522.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T22495</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326132.1">
        <property type="nucleotide sequence ID" value="XM_011327830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RR18"/>
    <dbReference type="EnsemblFungi" id="CEF84254">
        <property type="protein sequence ID" value="CEF84254"/>
        <property type="gene ID" value="FGRRES_06522"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06522"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22495"/>
    <dbReference type="eggNOG" id="ENOG502SNKC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090929_1_0_1"/>
    <dbReference type="InParanoid" id="I1RR18"/>
    <dbReference type="OrthoDB" id="3724345at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="entry name" value="dinb family like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018531">
        <property type="entry name" value="DUF1993"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922">
        <property type="entry name" value="BLL2446 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922:SF1">
        <property type="entry name" value="DUF1993 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09351">
        <property type="entry name" value="DUF1993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF84254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="177" mass="20500" checksum="564DA8786ECEC090" modified="2012-06-13" version="1">MTTLYQQSIPVLVKYLKNLSFLLQKGATFCEEKSLKHEEMLSYRLISDMRGPVPSPHLPYQVQSCSNTAKFLVSRFDAPNIPTFEDNEETFEHLQDRIAKTIEVLENVDPDVINGKEDVEIIMETKFGNYRFTGQRYISEYAIPNFHFHLTSAYCIMRTQGVPLGAFDYLKDVFEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RRT0</accession>
    <accession>A0A098DTA9</accession>
    <name>I1RRT0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T23261</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326472.1">
        <property type="nucleotide sequence ID" value="XM_011328170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RRT0"/>
    <dbReference type="FunCoup" id="I1RRT0">
        <property type="interactions" value="543"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RRT0"/>
    <dbReference type="EnsemblFungi" id="CEF84068">
        <property type="protein sequence ID" value="CEF84068"/>
        <property type="gene ID" value="FGRRES_06818"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06818"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23261"/>
    <dbReference type="eggNOG" id="KOG4392">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090381_2_1_1"/>
    <dbReference type="InParanoid" id="I1RRT0"/>
    <dbReference type="OrthoDB" id="10248581at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="46"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF84068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="142" mass="16439" checksum="E0A283227D9D40AF" modified="2012-06-13" version="1">MAGINPKHFNLQDDPLRYFELFELFLLGEGEKKIEEKVFSGMSNTSDFVLMKEDHTLGNLLSEHLKMHPNVHMAGYKIAHPNVPELFIRVQTDGTITPRDVFTSVCEKLINQLEMLHQEFTREWELRRITTAGEQGNMQNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RS52</accession>
    <name>I1RS52_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG06963.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T23617</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326640.1">
        <property type="nucleotide sequence ID" value="XM_011328338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RS52"/>
    <dbReference type="FunCoup" id="I1RS52">
        <property type="interactions" value="818"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RS52"/>
    <dbReference type="EnsemblFungi" id="CEF85763">
        <property type="protein sequence ID" value="CEF85763"/>
        <property type="gene ID" value="FGRRES_06963"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06963"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23617"/>
    <dbReference type="eggNOG" id="KOG3224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039187_0_1_1"/>
    <dbReference type="InParanoid" id="I1RS52"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF85763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="279" mass="31939" checksum="2FA17A05D4E268F6" modified="2012-06-13" version="1">MQQNHITNPNEPFPKPQALASATTTHSQGRFRISTRKLPISKAGTIDALTEQIGIPMPEMIFGENFVGIEHIPSGWSLNFNTPDALDAVDKTDRHMLKVAYARDWESTREGTTQGIKEIMKPYDWSYSTTYTGSVDPSAKQFAPTENMIPIELLKRRDPILFFDEVMLFESELDDNGISIFSAKVRVHEKRMLLLCRLFMRLDNVILRIRDTRVYVDFETDEVIREYSAQEETYENVKRKLQMSGRLPDEITIALRDPNILAPLLPLVEHRAEAIKLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1RT52</accession>
    <name>I1RT52_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG07349.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T24599</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327108.1">
        <property type="nucleotide sequence ID" value="XM_011328806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RT52"/>
    <dbReference type="STRING" id="229533.I1RT52"/>
    <dbReference type="EnsemblFungi" id="CEF83692">
        <property type="protein sequence ID" value="CEF83692"/>
        <property type="gene ID" value="FGRRES_07349"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07349"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24599"/>
    <dbReference type="eggNOG" id="ENOG502REK8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018589_0_1_1"/>
    <dbReference type="InParanoid" id="I1RT52"/>
    <dbReference type="OrthoDB" id="5405297at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="602"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF83692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="623" mass="68427" checksum="C9A779FE72F8E347" modified="2012-06-13" version="1">MRNPFRRRNKKDKAGSGGQSSDFVVPFEFRPQGAGCPPLYPPTRNSAYLLAHLPPKVLERIFAFVCPHALDESYETCEGSASSSDSVCMLCDLRDVAHCVQVCRAWRPSAVKVLYHSVRIDPVHYCRLEEWLAERRKKTSRFDRNGIPEDPAQARLRLLRRTVRDDPTRIGKYVQYLKLPYMLRESSQVELAQTIAVLPNLKYVDLPEGMFCDDPHYSTLRLEVQARCPNLRKMTYVGGSERSLAMLASGQVWPNLEVLELNNLNVDPAVIRAVLGSLDNLQALKVSNTPGLSDEVLSSSDGMATLPPIKELVLKDTPGVTLRGLIAYLAWQETQQALTVLTLKDTGVHPASLQEIFTMASSLKTLAIQSKVTEQFPSSIVTRPFSSQSLETLRYEISPASTGPFDSVTMGYYTFLATSILGGGFPKLRQLYVHDESFPDQLQGLPPPNAAFAGGHTRSGSNSSSKSNPVFGFSPPSNLLPASANLPMNRRPVSHVQPPSKRFSSNNPFAPRMPTSAAPTHTLEVFTKSDEFGKWNFVSVDPMFKSGSTTSRRPMSSYGLAADVTGPGWDRGDARRSVMVGNGTGVFLAVPGQGGDDGAFGGSSDPWRPQSSGGSPRRSRELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>I1RTE7</accession>
    <name>I1RTE7_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol regulatory element-binding protein cleavage-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">FG07450.1</name>
        <name evidence="25" type="ORF">FGRAMPH1_01T24853</name>
    </gene>
    <organism evidence="26">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="26">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="26 27" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="27">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="26">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="25 27" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="25">PH-1</strain>
        </source>
    </reference>
    <reference evidence="26" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat SCAP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327222.1">
        <property type="nucleotide sequence ID" value="XM_011328920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RTE7"/>
    <dbReference type="STRING" id="229533.I1RTE7"/>
    <dbReference type="EnsemblFungi" id="CEF83864">
        <property type="protein sequence ID" value="CEF83864"/>
        <property type="gene ID" value="FGRRES_07450"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07450"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24853"/>
    <dbReference type="eggNOG" id="KOG1933">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004183_0_0_1"/>
    <dbReference type="InParanoid" id="I1RTE7"/>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032936">
        <property type="term" value="C:SREBP-SCAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045540">
        <property type="term" value="P:regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030225">
        <property type="entry name" value="SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378:SF1">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="19" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="15 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="8 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 21" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="24">
        <location>
            <begin position="287"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="21">
        <location>
            <begin position="656"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1108"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1109"/>
            <end position="1118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CEF83864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1138" mass="126504" checksum="E6D33418010FAE35" modified="2012-06-13" version="1">MIWYFLYPLRGTTEAPILAPTHPVRRALYRYGSYAASHVVAALLVSVVVATILIYPIPYLFTSDYVNGASNLPHHAWTVAQPLPYGATIYPDVMMRSIWVHGSYMQALKQDLLVSALELQNELLGSTENFSPIRARNVARSLPEPGADLSTTQRDAFHAINGLNNQSWFFHSPLQYWDCTKENILVDPAILATVNDKKTQSTSVNVTLRHSIVFSGKRFEERRLVAADALVITLIYLRDSPVGKQWERKAALLPDEMSSKWDIYPPDGRSTASQLYEFQFRPISSQDTAILSAAYGLTAIYFLLSLTKLRAFKSKFGLIITVISQIAFSVMSSFTVCAIFRLDLSRIPRAAYPLVVLSMSLENIFRLINAVIIAPAEDSTSNRIGQAFGETAHTAITSSLQNVFLLLLLSRWVSPGVSAFCMFVAVAIGFDLFYLSTFFLSVLSVDVRRTELSDALAKASIRRYRGESDFKPRGAWERALQGKATLSTRIAGTIIMLGFILIAQWHFFEAAAIFNFFKHAYQGHGALENATSPQTSLDAIHQARSPKSWLRLQDHETAQEIISIIKPTAHSYVARVYEPVVFVMKGSDRMPHYKEPTLLPALYDFINHQLTQFVVIILVVIAGLRLLTSFLLWEDEADDDDRHSDTDPTLDVKSFHGGHSLDIAMLTAAPDGRIVSVGLDRAIRVWDAKSASLHYTIAKGEESEDAPFPVLAMAIDDSSKWLAILSPYKIALWDLKENTWGPSLSVNLQGQKTEAFFFGSSDPKRNIPRLVLVRRNGTLTEYIPDAGEGADYGICRSPLTCVRPLIGKRKDCLQLKVGRDTDPMTAIGSKQASPLVAIITASRRGCVHAATKETLSWNSRSVELEGIEHDGVHQVVPLASLGLFLIAGVTRVHLVNMEDYSLVHTFSTERMASRSMQSAFFSRSSSQLGADGLVWFTLCYTSADTGDCVVQTFAPPDDHDMIYYQNSATPPTSGWCAWESVKETKRHIQNPGSWSVLSDGGVVGIRQKSNRALDMQTNGRRKTEGLRHRSPRKEPGRDLFGRWEIWSAPQSGLLRTDETRPLFQANERAGHLIVTELGPVVRVGQRSIAFSFGNVVKLVTVGGHERFDSSATDNSSEHLNVGSRRRKPGALVRPRAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RTH2</accession>
    <name>I1RTH2_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG07476.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T24905</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ELOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327249.1">
        <property type="nucleotide sequence ID" value="XM_011328947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RTH2"/>
    <dbReference type="FunCoup" id="I1RTH2">
        <property type="interactions" value="670"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RTH2"/>
    <dbReference type="EnsemblFungi" id="CEF83459">
        <property type="protein sequence ID" value="CEF83459"/>
        <property type="gene ID" value="FGRRES_07476"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07476"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24905"/>
    <dbReference type="eggNOG" id="KOG3214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105983_0_0_1"/>
    <dbReference type="InParanoid" id="I1RTH2"/>
    <dbReference type="OrthoDB" id="445983at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000001">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="84"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF83459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="118" mass="12695" checksum="37C29814CF93A908" modified="2012-06-13" version="1">MGKRKSSSKPMGPKKKDPLPTTFACLFCNHENSVSVKLDKKAGVGQLDCRVCGQKFQCAVNYLSAAVDVYGEWVDAADAVAKEDTAEPGYGGTSRGGGRGNRTAVEDDYDDQYGDDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1RTI6</accession>
    <name>I1RTI6_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein JIP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">WD repeat-containing protein jip5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG07494.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T24945</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327269.1">
        <property type="nucleotide sequence ID" value="XM_011328967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RTI6"/>
    <dbReference type="FunCoup" id="I1RTI6">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RTI6"/>
    <dbReference type="EnsemblFungi" id="CEF84941">
        <property type="protein sequence ID" value="CEF84941"/>
        <property type="gene ID" value="FGRRES_07494"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07494"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24945"/>
    <dbReference type="eggNOG" id="KOG2444">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052691_0_0_1"/>
    <dbReference type="InParanoid" id="I1RTI6"/>
    <dbReference type="OrthoDB" id="2288928at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF20">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF84941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="414" mass="44601" checksum="24AF7D051236F2C1" modified="2012-06-13" version="1">MFENTCTLPLSADVFTTALHPSEPLLTVGLSNGHVETFRLPPGSSSDESADGDTSVLSDGKGMVDSVWSTRRHKGSCRSLVYAMDGSAVYSAGTDGLVKHFEPMTGQVVSKFAIPKYSGRDDAPTLLHVLNPQCILLATDSGLLHIYDVRNGTPEKKAVSEHRPHTDYISSITPLPPTQMSTSGFPKQFISTGGTTLAVTDFRRGVMVHSEDQEDELLSSCYISGMGPKGLRENGVIACGSGSGVLTLWDKGSWGDQQERIIVDGDRKGGESIDSTVLVPQEMGLGKKVVCGLGDGSLRVVDVVRREVDFAANLRHDTMESVVSLGFDSTNRLISAGGQTVKLWEELSALQGDGSDEEEEEDDRKRPAESDSDEDSEIDLKAELQKRAKRRKESMKSKLGGYGHHGVIGLEGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1RTM2</accession>
    <accession>A0A098DUL4</accession>
    <name>I1RTM2_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pectinesterase</fullName>
            <ecNumber evidence="3">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG07533.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T25033</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pectinesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327309.1">
        <property type="nucleotide sequence ID" value="XM_011329007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RTM2"/>
    <dbReference type="STRING" id="229533.I1RTM2"/>
    <dbReference type="EnsemblFungi" id="CEF85049">
        <property type="protein sequence ID" value="CEF85049"/>
        <property type="gene ID" value="FGRRES_07533"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07533"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25033"/>
    <dbReference type="eggNOG" id="ENOG502R6WA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143021_0_0_1"/>
    <dbReference type="InParanoid" id="I1RTM2"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF137">
        <property type="entry name" value="PECTIN METHYL ESTERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pectinesterase catalytic" evidence="6">
        <location>
            <begin position="33"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF85049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="163" mass="18342" checksum="5ACDA95492DA705C" modified="2012-06-13" version="1">MYQLAVATVDTSKDEFLGIHMNFSPRWLKSNTTFTNKYGVYIDNSQVIPSNSTIAKDMVGKCPLGRPWNSQHKSIFMQSYLDSVILPAGYIKWSAATPRVDNYTFMATWNDHGPGYNVTALKDGGITKVLTDKEAKPYKSPKDVFQTPEGKFGYVSWIDKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1RUD9</accession>
    <accession>A0A098DUL0</accession>
    <name>I1RUD9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG07829.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T25769</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327654.1">
        <property type="nucleotide sequence ID" value="XM_011329352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RUD9"/>
    <dbReference type="STRING" id="229533.I1RUD9"/>
    <dbReference type="EnsemblFungi" id="CEF85556">
        <property type="protein sequence ID" value="CEF85556"/>
        <property type="gene ID" value="FGRRES_07829"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07829"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25769"/>
    <dbReference type="eggNOG" id="ENOG502SQA8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053381_7_1_1"/>
    <dbReference type="InParanoid" id="I1RUD9"/>
    <dbReference type="OrthoDB" id="5415867at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124548" evidence="1">
        <location>
            <begin position="19"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF85556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="185" mass="19563" checksum="013E8000DD2806E7" modified="2012-06-13" version="1">MFSKIFSVSLLLAAAVSAAPASKTVRSIPDKTVTLTGVTHSVNAGLGGLRFDPDNVVAEVGDVVEWHFLPANHTVAQSSFGEPCEPLADGTGFFAGFNFATTAGQAPDVFQIVVEDSKPIWYYCAQQKGSHCQMGMVGVINQNFDNQDFSLRRHKELAALTGVSVIPPVQQGGSVIPNPNPNGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I1RWB1</accession>
    <name>I1RWB1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T10293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320176.1">
        <property type="nucleotide sequence ID" value="XM_011321874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RWB1"/>
    <dbReference type="KEGG" id="fgr:FGSG_08574"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10293"/>
    <dbReference type="eggNOG" id="ENOG502SVSE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075611_0_0_1"/>
    <dbReference type="InParanoid" id="I1RWB1"/>
    <dbReference type="OrthoDB" id="4203030at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB65625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="229" mass="25986" checksum="17CC7EF7C033FC8F" modified="2012-06-13" version="1">MTGAIATPRYSNDDFETASVRSAAPSYVSEAPSYHSTNPFPEALPSYSPPVRNHAVVRSSMIPSSSGTSTPTARQQTIGLPPVPSAPLRSQPNLNNFRIATWSSVSSNPAARHYQNVANRRLTAQRDPVDSIRRVMSDIAEQEPERYVTRPLEDPYLVGEVAASRARRERVARESGDDILIREDRQWDWFLARMKDSDERQRSWNSFRREQDVGSRKKLFRRMGGRRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RWN4</accession>
    <accession>A0A098DDT5</accession>
    <name>I1RWN4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG08710.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T10631</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320023.1">
        <property type="nucleotide sequence ID" value="XM_011321721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RWN4"/>
    <dbReference type="STRING" id="229533.I1RWN4"/>
    <dbReference type="EnsemblFungi" id="CEF77118">
        <property type="protein sequence ID" value="CEF77118"/>
        <property type="gene ID" value="FGRRES_08710"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08710"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10631"/>
    <dbReference type="eggNOG" id="KOG3859">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021805_1_0_1"/>
    <dbReference type="InParanoid" id="I1RWN4"/>
    <dbReference type="OrthoDB" id="5337438at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001827">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="151"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF77118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="521" mass="58821" checksum="D94EE103B14263DA" modified="2012-06-13" version="1">MNNEEPRRTSFGMLLRRSKSGDLGKAGRKAQALKEAELERQRHASTRIAPKLPEFANHTEQLSNSFGPELRPESPANVPRSADYSSIRPSGEYSRGYGNAAHAAPPVPPLPNNGFDPYARTESMTNRGRYSYASSAISTVNSPRRVRRRKDPTPMNILVIGTRNSGKTSFLEFLKTAFALPPKKRAKKGDDEVSQNHSIPSGRFIPHYLETEIDGERIGLTIWDSEGLENNVVDLQLREMSAFLESKFEETFAEEMKVVRSPGVQDTHIHATFLVLDPSRLDRNIASARNPAINGQQNGQLFSRVYGSLDESLELNALRTLQGKTTVIPVIAKADTITTKHMNVLKRSVWDSIKKAGLDPLEALGLDDEDGSSFSSEKIVEEDEEDDLENNRDGAQTPESPDFPLQGQRESPTASPSSKRLSTSSMRRHRVQEEAKEKEDEIPFLPLSIISPDLYEPDVIGRQFPWGFADPYNDEHCDFQRLKEAVFSEWRAELREASREQWYEGWRTNRLKQKDGPHRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RWR1</accession>
    <accession>A0A098DE02</accession>
    <name>I1RWR1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG08741.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T10713</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319987.1">
        <property type="nucleotide sequence ID" value="XM_011321685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RWR1"/>
    <dbReference type="EnsemblFungi" id="CEF77159">
        <property type="protein sequence ID" value="CEF77159"/>
        <property type="gene ID" value="FGRRES_08741"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08741"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10713"/>
    <dbReference type="eggNOG" id="ENOG502S6PS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_7_2_1"/>
    <dbReference type="InParanoid" id="I1RWR1"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF77159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="464" mass="52140" checksum="C28024CDF04E8CC3" modified="2012-06-13" version="1">MDQEPRNKKQREDATDYDELSAHGQLRSGAFKSNDREISEVRRTMLDYHDNYSVSPPTQTSKQYDALKEQARMDRATGSPASDISEQGRRNDPGVTSPLTHPNGISMFPKMSIIEQEAMSRQALAQAEEAIVADSDEYNSTDDAGYGSDNMSSASTSIGSSVRDYMFENGRRYHSFRAGAYNFPNDDVEQEREDMKHAMVRLLSGQNLHFAPLGDNPQNILDIGTGTGIWAIESKNTFLHALGEQYPSANVLGIDLSPIQPTWLPPNVHFMVDDVESSWLHPQNHFDYVHSRHTVQAVKDWPRLFDSALEHMKPGGWMELQEIHHYPHNARTGEAIKPCDHPIAQYWTYINEGLAALGVDFPAAAGGKLAIKMQAAGFVNVTERIFHVPLGTWPKNQVLKTVGLYWRTILNDGIQAIALGPMSRGMGWSREQIEVFLVSVRRAYSDNTALLYMPMHIVYGQKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1RWT2</accession>
    <name>I1RWT2_GIBZE</name>
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        <submittedName>
            <fullName evidence="6">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FGRAMPH1_01T10763</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319962.1">
        <property type="nucleotide sequence ID" value="XM_011321660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RWT2"/>
    <dbReference type="STRING" id="229533.I1RWT2"/>
    <dbReference type="KEGG" id="fgr:FGSG_08763"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10763"/>
    <dbReference type="eggNOG" id="KOG1911">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045874_0_0_1"/>
    <dbReference type="InParanoid" id="I1RWT2"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18657">
        <property type="entry name" value="CSD_Swi6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00300">
        <property type="entry name" value="ChSh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="64"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="125"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SCB65660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="249" mass="28603" checksum="C1F0DC984EB56550" modified="2012-06-13" version="1">MPPALSDDENSDLEEFTTPPRTIRKKSTSAVVSEKFEDTKPEDGSEEELDEDEDDDEDLDEDVFVVEAIKKHLIDEDGSLKFQVKWEGYDAKKDLTWEPEDNLRESAQEILDKYFNKLGGREKLFEETETASKTKKRRRTTNGTPNTTVSTTKRSRSDAHPANSTPPATSKPWSPPAGSWEDEIESIELEEDESIGKIIVYLRWKNGKKTKHDTDVVYRKCPQKMLRFYESHLKIDRGENKEVTEGAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RX62</accession>
    <name>I1RX62_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG08912.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T11159</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319790.1">
        <property type="nucleotide sequence ID" value="XM_011321488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RX62"/>
    <dbReference type="EnsemblFungi" id="CEF77382">
        <property type="protein sequence ID" value="CEF77382"/>
        <property type="gene ID" value="FGRRES_08912"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08912"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11159"/>
    <dbReference type="eggNOG" id="ENOG502RQWG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1441165_0_0_1"/>
    <dbReference type="InParanoid" id="I1RX62"/>
    <dbReference type="OrthoDB" id="5089740at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="188" mass="21155" checksum="7730F8A1E6CD1BDB" modified="2012-06-13" version="1">MLLQVNPDSAQTVVGESGPVVSDNDSEPPRYQVFHIEHSPNVHKIFIPTSFPRPAGYLYFVTDLSLQDHPQTTLPVTADVLKSSEQMGDIYQSRFVGYIASQDLDRMRAMIKEHSRPLVPSDYAPLPDYVTRCEVWHLLQNLRLQTSESSVYRPGSLSLHGKGDSVWFFKVAVLVGKTEQRIGISQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1RXX0</accession>
    <accession>A0A098DTC1</accession>
    <name>I1RXX0_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG09196.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T27693</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328583.1">
        <property type="nucleotide sequence ID" value="XM_011330281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RXX0"/>
    <dbReference type="FunCoup" id="I1RXX0">
        <property type="interactions" value="454"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RXX0"/>
    <dbReference type="EnsemblFungi" id="CEF84607">
        <property type="protein sequence ID" value="CEF84607"/>
        <property type="gene ID" value="FGRRES_09196"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09196"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27693"/>
    <dbReference type="eggNOG" id="KOG4003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_13_0_1"/>
    <dbReference type="InParanoid" id="I1RXX0"/>
    <dbReference type="OrthoDB" id="3341310at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01011">
        <property type="entry name" value="nicotinamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="9">
        <location>
            <begin position="10"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF84607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="223" mass="24445" checksum="72A689502CF99CEF" modified="2012-06-13" version="1">MTSQKSFKPALIIVDFQEDFCPPNGSLAVPEGRTIAPTINTLTALPFHLILATKDFHPPSHISFASNHPSSTPYTSTTTITHPRDSSRSYTTTLWPTHCVQGTPGADLVPELDVSRLHAVIEKGQDKRVEMYSAFYDPFRVSDSGLAGMLGEQNVTDVFVVGLAADFCVKATAEDAVKEGYSTWIVNEGTKPVMPDKWDECRKGMEDMGIKFTSVANAVDKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZB4</accession>
    <name>I1RZB4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG09747.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T26361</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327945.1">
        <property type="nucleotide sequence ID" value="XM_011329643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZB4"/>
    <dbReference type="FunCoup" id="I1RZB4">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RZB4"/>
    <dbReference type="EnsemblFungi" id="CEF85417">
        <property type="protein sequence ID" value="CEF85417"/>
        <property type="gene ID" value="FGRRES_09747"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09747"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26361"/>
    <dbReference type="eggNOG" id="ENOG502QRKP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023943_1_0_1"/>
    <dbReference type="InParanoid" id="I1RZB4"/>
    <dbReference type="OrthoDB" id="2195113at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="171"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF85417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="472" mass="53227" checksum="A5EAD1DA3FBDC39B" modified="2012-06-13" version="1">MAETATSPAPAAENKQAHVRPTKPDEEVFKKELAKAEKEHKASMDRLAAVKAKIDIAMPNKNKDQPNPTQQRRQELIAQANEIRQKQAGGKNARTGKLDQIKRLDEQVRSRIAEQKTAKAKVPYKSLEDVDRQIATLDKQVNSGTMKLVDEKKALSDISSLRKMRKNFGQFDDSQKQIDDLRAKIKEIKDSMDDPEQRALSDQYNKIQAEIDTIKAEQDEAYKGISSLRDERTKLQAEQQEKYTAIRKLKDDYYGQKKAFQAYDREAREARREKQRAEQERYHQERKKAEAERRLGDASDPAYLDEIRRANSLLQFLDPNHKVEKGPLMADTGLGAQAQRSVDESGLKGTKLLRKEDREEEYAPAVKKGKKGKKAGAGPSSNKFSVPPAVVEDCAAMGIDPPMSAADIPTVAEKVRAKLDFWKNDQEAQTQRNIEKAKKEIAELEAAEANGDKIEQATSDLKETSIADKQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZH5</accession>
    <name>I1RZH5_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial import receptor subunit TOM20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mitochondrial 20 kDa outer membrane protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial import receptor subunit tom20</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Translocase of outer membrane 20 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">FG09817.1</name>
        <name evidence="17" type="ORF">FGRAMPH1_01T26207</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
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            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the Tom20 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="FGRRES_09817"/>
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    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
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    </feature>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZM1</accession>
    <name>I1RZM1_GIBZE</name>
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        <submittedName>
            <fullName evidence="5">Chromosome 1, complete genome</fullName>
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    <gene>
        <name evidence="6" type="primary">FG09870.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T06721</name>
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    <organism evidence="6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318772.1">
        <property type="nucleotide sequence ID" value="XM_011320470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZM1"/>
    <dbReference type="FunCoup" id="I1RZM1">
        <property type="interactions" value="1353"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RZM1"/>
    <dbReference type="EnsemblFungi" id="CEF75165">
        <property type="protein sequence ID" value="CEF75165"/>
        <property type="gene ID" value="FGRRES_09870"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09870"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06721"/>
    <dbReference type="eggNOG" id="KOG0279">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_7_1"/>
    <dbReference type="InParanoid" id="I1RZM1"/>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030546">
        <property type="term" value="F:signaling receptor activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903138">
        <property type="term" value="P:negative regulation of cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903753">
        <property type="term" value="P:negative regulation of p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001125">
        <property type="term" value="P:negative regulation of translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031139">
        <property type="term" value="P:positive regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006521">
        <property type="term" value="P:regulation of amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000765">
        <property type="term" value="P:regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141014">
        <property type="term" value="P:ribosome hibernation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000039">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit beta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="11"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="144"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF75165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="316" mass="35002" checksum="53D2DB34E580663A" modified="2012-06-13" version="1">MAEQLILKGTLEGHNGWVTSLATSMENPNMLLSASRDKTLIIWNLTRDETQYGYPKRSLHGHSHIVSDCVISSDGAYALSASWDKTLRLWELATGTTTRRFVGHTNDVLSVSFSADNRQIVSGSRDRTIKLWNTLGDCKYTITDKGHTEWASCVRFSPNPQNPVIVSAGWDKLVKVWELSTCKLQTDHIGHTGYINTVTISPDGSLCASGGKDGTTMLWDLNESKHLYSLNANDEIHALVFSPNRYWLCAATASSIIIFDLEKKSKVDELKPEFPAAGKKSREPECVSLAWSADGQTLFAGYTDNIIRAWGVMSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZQ1</accession>
    <accession>A0A098D8D9</accession>
    <name>I1RZQ1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG09902.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T06801</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318808.1">
        <property type="nucleotide sequence ID" value="XM_011320506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZQ1"/>
    <dbReference type="FunCoup" id="I1RZQ1">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RZQ1"/>
    <dbReference type="EnsemblFungi" id="CEF75204">
        <property type="protein sequence ID" value="CEF75204"/>
        <property type="gene ID" value="FGRRES_09902"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09902"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06801"/>
    <dbReference type="eggNOG" id="ENOG502QR7R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_11_1_1"/>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318844.1">
        <property type="nucleotide sequence ID" value="XM_011320542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZT3"/>
    <dbReference type="STRING" id="229533.I1RZT3"/>
    <dbReference type="EnsemblFungi" id="CEF75241">
        <property type="protein sequence ID" value="CEF75241"/>
        <property type="gene ID" value="FGRRES_09937"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
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        <location>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF75241"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
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                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318862.1">
        <property type="nucleotide sequence ID" value="XM_011320560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZU8"/>
    <dbReference type="EnsemblFungi" id="CEF75261">
        <property type="protein sequence ID" value="CEF75261"/>
        <property type="gene ID" value="FGRRES_09953"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09953"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06913"/>
    <dbReference type="eggNOG" id="ENOG502SW4P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057902_1_0_1"/>
    <dbReference type="InParanoid" id="I1RZU8"/>
    <dbReference type="OrthoDB" id="424402at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF75261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="210" mass="23496" checksum="3B0D5A3384E32EFC" modified="2012-06-13" version="1">MSNANLTQSSGKRSPDTNLSGNSQPIKRTRSDDVQIQTFALGAPHESIIAELKPKYDVLPASVISSTQIKKRVTHVANHLLAQGDRRQIALLYARTADVCKLITVVEKCKQVLSEEGKQHYQYNQLFDQPEKPRRKDIVEETILEKGTMDEEGDGSGSDDFEVMHSRFEDAVLPRPSQRIIKSMRVFLSIIPIPELKLKKGVTVQSGTAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-04-25" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1S039</accession>
    <name>ATG5_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ATG5</name>
        <name type="ORF">FG10053</name>
        <name type="ORF">FGRAMPH1_01T07167</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2017" name="Sci. Rep." volume="7" first="11062" last="11062">
            <title>Genome-wide functional analysis reveals that autophagy is necessary for growth, sporulation, deoxynivalenol production and virulence in Fusarium graminearum.</title>
            <authorList>
                <person name="Lv W."/>
                <person name="Wang C."/>
                <person name="Yang N."/>
                <person name="Que Y."/>
                <person name="Talbot N.J."/>
                <person name="Wang Z."/>
            </authorList>
            <dbReference type="PubMed" id="28894236"/>
            <dbReference type="DOI" id="10.1038/s41598-017-11640-z"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="1 2">Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation (By similarity). Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation (By similarity). Required for selective autophagic degradation of the nucleus (nucleophagy) (By similarity). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production (By similarity). Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function (By similarity). The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity). ATG12-ATG5 rearranges the ATG3 catalytic center and enhances its E2 activity (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Conjugated with ATG12 (By similarity). The ATG5-ATG12 conjugate forms a complex with several units of ATG16 (By similarity). The ATG12-ATG5 conjugate also associates with ATG3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Localizes to the isolation membrane (IM), a membrane sac which is generated from the pre-autophagosomal structure (PAS) (By similarity). Ultimately, the IM expands to become a mature autophagosome (By similarity). Localizes also to a dot at the junction between the IM and the vacuolar membrane, termed the vacuole-IM contact site (VICS) (By similarity). Correct localization to the PAS requires ATG21 (By similarity).</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Conjugated to ATG12; which is essential for autophagy (By similarity). Conjugation with ATG12 involves ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="2">Blocks autophagy (PubMed:28894236). Significantly decreases the radial growth of colonies under nutrient-rich conditions (PubMed:28894236). Strongly reduces conidiation and completely fails to form any perithecia (PubMed:28894236).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATG5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318981.1">
        <property type="nucleotide sequence ID" value="XM_011320679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S039"/>
    <dbReference type="SMR" id="I1S039"/>
    <dbReference type="STRING" id="229533.I1S039"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T07167">
        <property type="protein sequence ID" value="FGRAMPH1_01T07167-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G07167"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10053"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07167"/>
    <dbReference type="eggNOG" id="KOG2976">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051894_2_0_1"/>
    <dbReference type="InParanoid" id="I1S039"/>
    <dbReference type="OrthoDB" id="272162at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.190">
        <property type="entry name" value="Autophagy protein Apg5, helix rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048940">
        <property type="entry name" value="ATG5_HBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042526">
        <property type="entry name" value="Atg5_HR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048939">
        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042527">
        <property type="entry name" value="Atg5_UblA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048318">
        <property type="entry name" value="ATG5_UblB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20638">
        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04106">
        <property type="entry name" value="ATG5_UblB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-1017">Isopeptide bond</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0832">Ubl conjugation</keyword>
    <feature type="chain" id="PRO_0000443875" description="Autophagy-related protein 5">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ATG12)" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q12380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="28894236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="28894236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF75388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="254" mass="28023" checksum="6D2539EF3FF5AC9D" modified="2012-06-13" version="1">MSSPIPQALWSAQIPLHITHPASPTTPFITSIPRFSYLALLIPRLSTFFNSPCSSFHFEDVQLRNLAVGLLVDLYQPALPWKLTVNDGVGWDIADTFLNCVKEADFVRNGNANQIMKMSKENTTQLWNAVIDNDHPSFNRINSHLLNAPTALKHVPIRIYVPTSGPDSSATHPEHATFKVIQSLMAATSSDRRPKLLGQALKEVLPGLFPSSRDPILAKVVMHGAGVPFDAPLEDLMREAAYPDGWLCLVVIVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I1S050</accession>
    <name>YCK1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine protein kinase YCK1</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Casein kinase I homolog 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">YCK1</name>
        <name type="ORF">FG10066</name>
        <name type="ORF">FGRAMPH1_01T07201</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2011" name="PLoS Pathog." volume="7" first="e1002460" last="e1002460">
            <title>Functional analysis of the kinome of the wheat scab fungus Fusarium graminearum.</title>
            <authorList>
                <person name="Wang C."/>
                <person name="Zhang S."/>
                <person name="Hou R."/>
                <person name="Zhao Z."/>
                <person name="Zheng Q."/>
                <person name="Xu Q."/>
                <person name="Zheng D."/>
                <person name="Wang G."/>
                <person name="Liu H."/>
                <person name="Gao X."/>
                <person name="Ma J.W."/>
                <person name="Kistler H.C."/>
                <person name="Kang Z."/>
                <person name="Xu J.R."/>
            </authorList>
            <dbReference type="PubMed" id="22216007"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002460"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2022" name="Int. J. Mol. Sci." volume="23" first="0" last="0">
            <title>Stage-Specific Genetic Interaction between FgYCK1 and FgBNI4 during Vegetative Growth and Conidiation in Fusarium graminearum.</title>
            <authorList>
                <person name="Zhu J."/>
                <person name="Hu D."/>
                <person name="Liu Q."/>
                <person name="Hou R."/>
                <person name="Xu J.R."/>
                <person name="Wang G."/>
            </authorList>
            <dbReference type="PubMed" id="36012372"/>
            <dbReference type="DOI" id="10.3390/ijms23169106"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3">Serine/threonine protein kinase required for vegetative growth, sexual/asexual development, and pathogenesis (PubMed:22216007, PubMed:36012372). Involved the regulation of polarized hyphal growth and cell wall integrity, possibly via RHO1 signaling (PubMed:36012372).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vacuole lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="2 3">Produces wavy hyphae with reduced branching, and hyphae are narrower and often have swollen tips (PubMed:22216007). Causes severe growth defects and loss of conidiation, fertility, and pathogenicity (PubMed:36012372). Also shows defects in polarized growth, cell wall integrity, internalization of RHO1 and vacuole fusion (PubMed:36012372).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318996.1">
        <property type="nucleotide sequence ID" value="XM_011320694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S050"/>
    <dbReference type="FunCoup" id="I1S050">
        <property type="interactions" value="642"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1S050"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T07201">
        <property type="protein sequence ID" value="FGRAMPH1_01T07201-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G07201"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10066"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07201"/>
    <dbReference type="eggNOG" id="KOG1165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019279_1_1_1"/>
    <dbReference type="InParanoid" id="I1S050"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="PHI-base" id="PHI:1203"/>
    <dbReference type="PHI-base" id="PHI:123410"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14127">
        <property type="entry name" value="STKc_CK1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000463445" description="Serine/threonine protein kinase YCK1">
        <location>
            <begin position="1"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="19"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="22216007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="36012372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="22216007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="36012372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="22216007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75405"/>
        </source>
    </evidence>
    <sequence length="453" mass="50503" checksum="2243748D2AD3BB0B" modified="2012-06-13" version="1">MASSSSNVVGVHYRVGKKIGEGSFGVIFEGTNLLNNQQVAIKFEPRKSDAPQLRDEYRTYKILVGCPGIPNVYYFGQEGLHNILVIDLLGPSLEDLFDHCGRRFSIKTVVMVAKQMLSRVQTIHEKNLIYRDIKPDNFLIGRPGTKASSVIHVVDFGMAKQYRDPKTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDDLEALGHVFLYFLRGGLPWQGLKAATNKQKYEKIGEKKQTTIIKDLCEGFPEEFSKYLTYVRNLGFEDTPDYDYLRELFTQALKNTGEVEDGEYDWMKISKDSGKGWDSKNHSNAYLHNPNVRPGPSQMELHSGHRPGNTTSHQQAQNLTVGRLNAAQPPPPSPIKQMGKQRDRPSAPGALSAQRGSGVGGLRDMATPTGSTQAQFQNSAQNLPQQPRTSQQGPATQPTQASGQPANPQPSGFQKLMKTLCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>I1S099</accession>
    <name>I1S099_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">Ketol-acid reductoisomerase, mitochondrial</fullName>
            <ecNumber evidence="5 17">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">Acetohydroxy-acid reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 17">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">FG10118.1</name>
        <name evidence="21" type="ORF">FGRAMPH1_01T07331</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="22">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="23">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="22">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>PH-1</strain>
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    <reference evidence="21 23" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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            <strain evidence="23">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="21">PH-1</strain>
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        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <strain evidence="22">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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        <text evidence="17">Binds 2 magnesium ions per subunit.</text>
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        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
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    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
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    <comment type="subcellular location">
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            <location evidence="1 17">Mitochondrion</location>
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    <comment type="similarity">
        <text evidence="4 17 18">Belongs to the ketol-acid reductoisomerase family.</text>
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        <location>
            <begin position="65"/>
            <end position="255"/>
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        <location>
            <position position="264"/>
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        <ligand>
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    <sequence length="405" mass="44908" checksum="61C6AF99723A33FA" modified="2012-06-13" version="1">MASRNLSKALRGPARQLASAPRVQQRTFVSAARAAVRAGAVARPVASGPIQQQIRGVKTMDFAGHKEDVYERADWPQEKLLEYFKNDTLALIGYGSQGHGQGLNLRDNGLNVIVGVRKNGKSWKDAEQDGWVAGKNLFDVDEAIGRGTIVMNLLSDAAQSETWPAIKPQLVKGKTLYFSHGFSPVFKDLTKVEVPTDIDVILCAPKGSGRTVRSLFREGRGINSSFAVYQDVTGKAEEKAIALGVAIGSGYLYKTTFEKEVYSDLYGERGCLMGGIHGMFLAQYEVLRERGHSPSEAFNETVEEATQSLYPLIGANGMDWMYEACSTTARRGAIDWSPKFKDALKPVFNSLYDAVKDGSETKRSLEYNSQPDYREKYEAEMKEIRELEIWRAGKAVRSLRPENQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1S108</accession>
    <accession>A0A098DBI2</accession>
    <name>I1S108_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG10401.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T08007</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319371.1">
        <property type="nucleotide sequence ID" value="XM_011321069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S108"/>
    <dbReference type="STRING" id="229533.I1S108"/>
    <dbReference type="EnsemblFungi" id="CEF75807">
        <property type="protein sequence ID" value="CEF75807"/>
        <property type="gene ID" value="FGRRES_10401"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10401"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08007"/>
    <dbReference type="eggNOG" id="ENOG502SRXU">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_065647_0_0_1"/>
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    <dbReference type="OrthoDB" id="3558741at2759"/>
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        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cyt_trans-like"/>
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        <property type="entry name" value="CTP_transf_like"/>
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        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="1">
        <location>
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            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF75807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="356" mass="40107" checksum="410C1965FDD71ED3" modified="2012-06-13" version="1">MSSPRLADYVERLIPADYKSSNLSDRPFNNGTARDPPLLRPRGVNHILLYPGSFNPPHQGHLNLLKHTFMNAGADLNLVAAIIVPCSDESVKGKMERRGSDMVFPKEKRIKLWCGNGIPVDWAWVYDGSEDWRAFRTRLTNAVRNDAMELTFMVLQGPDIINTERGYFPSGWDCSDAVTTDISRAVDFRYPSTLRQIGGCTPWKKLNVDRYSIEQRIRAKLKGSPESVIDEAVTKAMENLDAIWVCMQVYDKPHGIVRFLKSDLSKHTADAPSSTKIRAIIDSSPPEELEKNLQGIALHPDLLVKYLKELPKLVNCAEPAKTVKPVGPLEVCEWECSLDSPIDWSDDEKTTPESDW</sequence>
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    <accession>I1S118</accession>
    <name>I1S118_GIBZE</name>
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        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
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        <name evidence="2" type="primary">FG10412.1</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319386.1">
        <property type="nucleotide sequence ID" value="XM_011321084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S118"/>
    <dbReference type="EnsemblFungi" id="CEF75827">
        <property type="protein sequence ID" value="CEF75827"/>
        <property type="gene ID" value="FGRRES_10412"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10412"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08047"/>
    <dbReference type="HOGENOM" id="CLU_2109186_0_0_1"/>
    <dbReference type="InParanoid" id="I1S118"/>
    <dbReference type="OrthoDB" id="5017277at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF75827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="115" mass="13244" checksum="4F68660837C0E17F" modified="2012-06-13" version="1">MPNVSVLFTKRDIRAITNGDIHWLVAVKLARLSPRAYFYFSTFLWFDDFVGSLPGPYSRTPQHLYERVMAFGRHKMQEIHLSTKREREELMQKSNAAAAVTLSGHVFSDDDLIAL</sequence>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1S1H6</accession>
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        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF76028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319577.1">
        <property type="nucleotide sequence ID" value="XM_011321275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S1H6"/>
    <dbReference type="EnsemblFungi" id="CEF76028">
        <property type="protein sequence ID" value="CEF76028"/>
        <property type="gene ID" value="FGRRES_10578"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10578"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08451"/>
    <dbReference type="eggNOG" id="ENOG502SIIC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003953_2_1_1"/>
    <dbReference type="InParanoid" id="I1S1H6"/>
    <dbReference type="OrthoDB" id="5135333at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="183"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="687" mass="78644" checksum="02939482B6D60678" modified="2012-06-13" version="1">MDAIQPTFDPARDYPKWTANCSTCKAIWYQFAHPDSAPEVSLGFYEEALSTTCPNHKILVQKFIAYIRSKGIDEERYNIGDLGLYKRGGFHREVSLLASISKSGQGWKLLLLNKPDVPKHPGNGRILDPHWADVEAVKGWKHKCLSFHGAKCQNLLKVSPARPAWLVDVQNQCIVSGDECSSYMALSYTYGSHTHPEITSEDFAMLQEPFALANTTFSAYISPIIRHAMYLTSTIDERYLWADALCVTHHDPEAASEQLATMGTIYTNAVVTIIAVDGDSQSGIPGLKGWTFQEYSFSSRKIVLLDHELHWMCACTTWHEEVTLYTEIDHIFRYQFDLLTAGFPADFCLTQYAMDYNQRFLTFQEDALPAISGLLSVLSRSFEGGFLYGIPEMFFEHSLGWWGMDMQRRVSSDRPTEKQFAFSSLPSWSWIGWQGYVFYREQTAIRVWSNPIEEAFPITEWYTSNSPSDPPDLRRRIRSTWYEKRDGFKDFAKPMPPGWSRRETSSPRAHPDGCEKYVFQHESFQKWLGKPLEWYYPFPIHEINASTPPSMPDQTQYLFCETFQTTLPCYRGDSPNLILRANICGQSGEMIGRLGLVNKDSWMRFPEEGDGTEAGLQVDLVAICKLKRYTKPKENFVAVDLPQTTEDLYSVLWIEWKDGIAYRLASGEVIAEEWEKLDLKKISLILG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-06-17" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I1S3K8</accession>
    <accession>A0A098E1Z9</accession>
    <name>CHRY2_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidase chry2</fullName>
            <ecNumber evidence="6">3.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Chrysogine biosynthesis cluster protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">chry2</name>
        <name type="ORF">FG11396</name>
        <name type="ORF">FGRAMPH1_01T21961</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2017" name="J. Nat. Prod." volume="80" first="2131" last="2135">
            <title>Chrysogine biosynthesis is mediated by a two-module nonribosomal peptide synthetase.</title>
            <authorList>
                <person name="Wollenberg R.D."/>
                <person name="Saei W."/>
                <person name="Westphal K.R."/>
                <person name="Klitgaard C.S."/>
                <person name="Nielsen K.L."/>
                <person name="Lysoee E."/>
                <person name="Gardiner D.M."/>
                <person name="Wimmer R."/>
                <person name="Sondergaard T.E."/>
                <person name="Soerensen J.L."/>
            </authorList>
            <dbReference type="PubMed" id="28708398"/>
            <dbReference type="DOI" id="10.1021/acs.jnatprod.6b00822"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="3 6">Amidase; part of the gene cluster that mediates the biosynthesis of the yellow pigment chrysogine (PubMed:28708398). Pyruvic acid and anthranilic acid are likely substrates for the nonribosomal peptide synthetase chry1/NRPS14, with pyruvic acid adenylated by the first A domain and anthranilic acid by the second (Probable). If pyruvic acid and anthranilic acid are merged and released from chry1/NRPS14 by hydrolysis, a subsequent amidation would lead to 2-pyruvoylaminobenzamide (Probable). This process is probably catalyzed by the amidotransferase chry2 using glutamine as amino donor (Probable). The dehydrogenase chry5 that has a terminal berberine bridge domain for C-N cyclization could catalyze the cyclization of 2-pyruvoylaminobenzamide to yield acetyl-4(3H)-quinazolidinone (Probable). A final reduction of acetyl-4(3H)-quinazolidinone catalyzed by the oxidoreductase chry4 would result in chrysogine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Pigment biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="3.-.-.-" evidence="6"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325837.1">
        <property type="nucleotide sequence ID" value="XM_011327535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S3K8"/>
    <dbReference type="SMR" id="I1S3K8"/>
    <dbReference type="STRING" id="229533.I1S3K8"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T21961">
        <property type="protein sequence ID" value="FGRAMPH1_01T21961-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G21961"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11396"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21961"/>
    <dbReference type="eggNOG" id="KOG0571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014658_1_0_1"/>
    <dbReference type="InParanoid" id="I1S3K8"/>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000155">
        <property type="entry name" value="Asparagine synthetase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051786">
        <property type="entry name" value="ASN_synthetase/amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43284:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43284">
        <property type="entry name" value="ASPARAGINE SYNTHETASE (GLUTAMINE-HYDROLYZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000450173" description="Amidase chry2">
        <location>
            <begin position="1"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="251"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="28708398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="28708398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="28708398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF87644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="671" mass="76115" checksum="B277CA9F7F0B0F74" modified="2012-06-13" version="1">MCGISAFITHPGHSRSPVLNGDAKQVVEELETSLDLIAHRGPDARGRWFSDNHHVGLGHVRLSIIDLSPSGNQPFHDEQGGIHAVVNGELYDYERYKAQLADEFKFVGNSDCEIVIALYKHYGLSFISHLRGEFAFVLWDENRQQLIAARDRYGIKSLYYTVHQNKLLVATEIKSFLAFGLEPEWCVRSLRDQSWRVDSTTFFEGVYKVRPGHYLICRPNEREEQHPYWDLEYPDKFAKDLRSEDEITEGVRERLLEAVRIRLKADVPVAVYLSGGIDSSSVAGMVSHLIKQGTKLGNETSLLPSSMKCYTVQFDEGSGADESAIARRTADFLGVDIHLVKMDEEALVSRFEDTTWYSEVPLPDLNGMGRLALAEAVHAQGIKAVITGEGSDEHFGGYDAFRADSLSEPDHSWPAMMTDTERQEAHALASKEAQYGIFGDFTPKVPISTKRMFYSNHVASSIARVGSLPFSDWTKVYGNSIPETTMIEGFDGRVRDNILKRWHPVHTAQYMFVKTFMPHFILRYNGDNIDMVHQVESRCPFLDHHLTEYVNNVPPSLKMRYNAKDKSWREKHILREAVKPFVTDEVYNMSKKAYMGPRKFWPGGPLHKKISELVTKANVENLGFVDWQATQDAMDGAFNKQEGLALRRIITVAQFVVLGQRFGVKRASGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I1S511</accession>
    <name>I1S511_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T03239</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317094.1">
        <property type="nucleotide sequence ID" value="XM_011318792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S511"/>
    <dbReference type="EnsemblFungi" id="CEF73422">
        <property type="protein sequence ID" value="CEF73422"/>
        <property type="gene ID" value="FGRRES_11929"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11929"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03239"/>
    <dbReference type="HOGENOM" id="CLU_2277751_0_0_1"/>
    <dbReference type="InParanoid" id="I1S511"/>
    <dbReference type="OrthoDB" id="10339505at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF73422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="102" mass="11455" checksum="11B27BBD186A8D09" modified="2012-06-13" version="1">MSRRNVDNFSTRLISPPFRLVSHRKHLVGPMSSVILAVRIRELLARLGLARFEIVQGRKIARMMWQMRLKSSGRNLRVMAASDGVTQFAPAVNATAALELVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I1S542</accession>
    <accession>A0A098D584</accession>
    <name>I1S542_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T03619</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <property type="gene ID" value="FGRRES_11960"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03619"/>
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        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF73615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="107" mass="11978" checksum="3C2446DEBE90BDD6" modified="2012-06-13" version="1">MGSEPRVRKRDDTSSKEKRKWREAVGEGDEETHPSRVNQLGQGTIKAGQGKARQRKGKAKQRRGLPLTSNHRLRRDSLGSYTEHNVSNCPTKPPWACVDGGMQQLVS</sequence>
</entry>
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    <accession>A0A098E275</accession>
    <name>I1S7P3_GIBZE</name>
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            <fullName evidence="1">Chromosome 3, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324749.1">
        <property type="nucleotide sequence ID" value="XM_011326447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S7P3"/>
    <dbReference type="EnsemblFungi" id="CEF88200">
        <property type="protein sequence ID" value="CEF88200"/>
        <property type="gene ID" value="FGRRES_12868"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12868"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19537"/>
    <dbReference type="HOGENOM" id="CLU_1332037_0_0_1"/>
    <dbReference type="InParanoid" id="I1S7P3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF88200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="206" mass="23202" checksum="1A9BF373EEC53A64" modified="2012-06-13" version="1">MPLGRLHISNRGSFVSHHRRAGKDSYIHQALRFVSTPLAWFYIQLGQASKCGWMLAKISCVRQRDFSYSTTSTHRKGWIRRLATSKSGTGFRGQTERVKHGMMTGAMRAEKGTSSGTNSLGLNVDPLAAADAHLFLSIFSYSHVREAIVSPPFDIFTSIKLVMEPESFLKNTKNNTMLVLCTRHEGLLWHTKSLDNNFVRLPLHPQ</sequence>
</entry>
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    <accession>I1S832</accession>
    <accession>A0A098DSF7</accession>
    <name>I1S832_GIBZE</name>
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        <submittedName>
            <fullName evidence="10">Chromosome 4, complete genome</fullName>
        </submittedName>
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        <name evidence="11" type="primary">FG06882.1</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326543.1">
        <property type="nucleotide sequence ID" value="XM_011328241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S832"/>
    <dbReference type="EnsemblFungi" id="CEF84279">
        <property type="protein sequence ID" value="CEF84279"/>
        <property type="gene ID" value="FGRRES_13008"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13008"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23407"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003487_0_1_1"/>
    <dbReference type="InParanoid" id="I1S832"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="PHI-base" id="PHI:1723"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
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    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="152"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF84279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="896" mass="99731" checksum="23B3ACBBAA70F8E1" modified="2012-06-13" version="1">MSGPSSSTNPPTNPPSIETPAPNPEKGHQLYACGHCGRRYSRPEHLQRHVQTHTLGRRFACGICGKTFARADLKKRHETNHENDDSKKRRRTTTALNSGRVTHACKACAAARVKCQEEKPCQRCTRRGLTCVSSDAGSAAAMNLVHLSASARSNDDEYESGPSTGPSTGPAPTSFPLDQTSLYGQTVQLQSQPQSRSGTPNTGDLTRSEASSSQQPDADQLPFCDFLRDVLYEQQYDQPARMPDNTGLDVLDFCNDTNMELSDMDFGLLDHWNAGGTGPNNPNAILAQVDTPRSDNSADVAHAHIRQNLVTAWDVSPWRWDPVAKDNAFGEQGNLPVSKKDVASLQAEASQGGLRRVVDQRLDFAARDGVLALVLGACQPDAMSSRISGSFPSADLLDTMLHVFLNSHTNQVSEYIHFPTFKLNEQEPEWIAGAAAAGAVLTPIPTLRKFGYALQEAIRIVMPKRFEENNESILNIGLIHAIVIGQDTGLWSGNRRKMEIAECHVNIPTTMMRYRGKFQRSTYPMLSVTAADEGANLEQKWRTWVDMEKWKRFVFHLFLRDSQQSMTALTNPVMSYAELTLPLPASKELWYAKTARDWKHAYLRREDGHVKRAPSVGDLFRDLNLLAENRHRLDVQLSAAIYLQAYWLLILEYRNLCSSYRIRSYTQDPYGNTNSLLNARRHQLLQDLQTFKVTTMNWPEITAQERLLLNQLMMALHISIDDLQLFAGKEGDEQAHRAFHVLQQWVESVDSRAAIWHAGQVLRFAKLFPSAQLKNFYAVGVHHAALAIWTYGVIKKAGSKQDVSSQHEKIYIDGPESMGIQRYINTGQGLPVFRGPASRNGVSEATIENPKAGMEAIHEILQANFGGANRMAPAIVENLCVLIRQLGNVAWAVGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I1S869</accession>
    <accession>A0A098DTU7</accession>
    <name>I1S869_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T23801</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326730.1">
        <property type="nucleotide sequence ID" value="XM_011328428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S869"/>
    <dbReference type="EnsemblFungi" id="CEF84769">
        <property type="protein sequence ID" value="CEF84769"/>
        <property type="gene ID" value="FGRRES_13047"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13047"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23801"/>
    <dbReference type="HOGENOM" id="CLU_1245474_0_0_1"/>
    <dbReference type="InParanoid" id="I1S869"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF84769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="222" mass="24577" checksum="E4BACD1432015EBA" modified="2012-06-13" version="1">MPRNLERLRAPTQTGMQAAQYGTGSWGLASTESNHPAGSNGETRGEGERKQGNKETEAAHSTAQHSTVQIHMDKCGAQPNIPLHSDRHLTICPIQRNERSACFNKKANSEKFYLKRIIVFRFASSHWGLLSEIAISEPEKVEAWVGREKCLDNGVSSLKKSDLPSPHVTLSMGCRGQHSCPSNRNKLHQSHPRQESQATELALAGIVVLAATQRQHTEYHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I1S8B7</accession>
    <accession>A0A098DR00</accession>
    <name>I1S8B7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T24261</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326947.1">
        <property type="nucleotide sequence ID" value="XM_011328645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S8B7"/>
    <dbReference type="EnsemblFungi" id="CEF83779">
        <property type="protein sequence ID" value="CEF83779"/>
        <property type="gene ID" value="FGRRES_13095"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13095"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24261"/>
    <dbReference type="HOGENOM" id="CLU_2038300_0_0_1"/>
    <dbReference type="InParanoid" id="I1S8B7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF83779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="121" mass="12996" checksum="BD92DE1B915E0CA3" modified="2012-06-13" version="1">MFPCPTSAGWVNATARAVANQPMSSVSGINRPAQVSLRPWDFDLGNPGTGSTQYLVFGSSAGEASVNVKSRMPTDRENWLTTSCPLSPACLFMYVHTALSGSDNRLHRGDTFFSNVALLLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-05-01" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q4HXF0</accession>
    <accession>A0A0E0RWY4</accession>
    <accession>A0A1C3YJM8</accession>
    <accession>I1S0W7</accession>
    <name>GUAA_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName>GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="1">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">GUA1</name>
        <name type="ORF">FGRAMPH1_01T07911</name>
        <name type="ORF">FGRRES_17731</name>
        <name type="ORF">FGSG_10358</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="sequence caution" evidence="7">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="ESU17065" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="1"/>
    <dbReference type="EMBL" id="DS231669">
        <property type="protein sequence ID" value="ESU17065.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319327.1">
        <property type="nucleotide sequence ID" value="XM_011321025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4HXF0"/>
    <dbReference type="SMR" id="Q4HXF0"/>
    <dbReference type="FunCoup" id="Q4HXF0">
        <property type="interactions" value="1082"/>
    </dbReference>
    <dbReference type="STRING" id="229533.Q4HXF0"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T07911">
        <property type="protein sequence ID" value="FGRAMPH1_01T07911-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G07911"/>
    </dbReference>
    <dbReference type="GeneID" id="23557267"/>
    <dbReference type="KEGG" id="fgr:FGSG_10358"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07911"/>
    <dbReference type="eggNOG" id="KOG1622">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_0_5_1"/>
    <dbReference type="InParanoid" id="Q4HXF0"/>
    <dbReference type="OrthoDB" id="1724632at2759"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000002">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0332">GMP biosynthesis</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000286150" description="GMP synthase [glutamine-hydrolyzing]">
        <location>
            <begin position="1"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-1" evidence="5">
        <location>
            <begin position="17"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="GMPS ATP-PPase" evidence="6">
        <location>
            <begin position="212"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="240"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>XMP</name>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>XMP</name>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>XMP</name>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>XMP</name>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; ESU17065." ref="1">
        <original>P</original>
        <variation>R</variation>
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; ESU17065." ref="1">
        <original>N</original>
        <variation>I</variation>
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P49915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q4WFT3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="4">
        <source>
            <dbReference type="UniProtKB" id="Q9P772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="545" mass="59691" checksum="8E1954DF8F02B63D" modified="2016-09-07" version="3">MSDAFETAAPPHATYDTVLVLDMGSQTSHLILRRLRSLGVYSEMLPCTQKIKDLGWKPVGVILSGGPSSVYADDAPGVDPLVFELGVPVLGVCYGNQLIAWRANPKSVAPGVNREYGETQMAIHKIGTHGDRLFEGLGDSLNVVMSHFDKVVQLPDGFQTIATTKNSEFAGIAHETQPIFGIQFHPEISHTEKGTDIIANFATKICGARPDWKMDDFSAREIKRIRELVGDKAQVIGAVSGGVDSTVAAKLMKEAIGDRFHAILVDQGLMRLNECEQVKETLDKHLGINLTVVDGSELFLGRLAGVTEPEAKRKIIGGTFIDLFEIEALRIEKEAENTDRAGKVEWFLQGTLYADIVESLSFKGAASSTIKSHHNAGGLPARMQNGEAQLKLLEPLRELFKDEVRAFGRQLGIHEELIGRHPFPGPGLGIRIIGEVTPERVEIVRKADHIFISMIREAGIYDEVTQAYAALDSSRAVGVQGDARVYGYICILRAVTSLDMMSAEPYEFTWSLMKAISRRIVNEVDGIARVVYDTTSKPPGTIELE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-25" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q4IQ08</accession>
    <accession>A0A098D182</accession>
    <accession>A0A0E0RN58</accession>
    <accession>V6QUB9</accession>
    <name>GWT1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName>GPI-anchored wall transfer protein 1</fullName>
            <ecNumber>2.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">GWT1</name>
        <name type="ORF">FGRRES_00700</name>
        <name type="ORF">FGSG_00700</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text>Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PIGW family.</text>
    </comment>
    <dbReference type="EC" id="2.3.-.-"/>
    <dbReference type="EMBL" id="DS231663">
        <property type="protein sequence ID" value="ESU05918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316403.1">
        <property type="nucleotide sequence ID" value="XM_011318101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4IQ08"/>
    <dbReference type="SMR" id="Q4IQ08"/>
    <dbReference type="FunCoup" id="Q4IQ08">
        <property type="interactions" value="570"/>
    </dbReference>
    <dbReference type="STRING" id="229533.Q4IQ08"/>
    <dbReference type="GlyCosmos" id="Q4IQ08">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T01765">
        <property type="protein sequence ID" value="FGRAMPH1_01T01765-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G01765"/>
    </dbReference>
    <dbReference type="GeneID" id="23548178"/>
    <dbReference type="KEGG" id="fgr:FGSG_00700"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01765"/>
    <dbReference type="eggNOG" id="KOG0411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020802_2_2_1"/>
    <dbReference type="InParanoid" id="Q4IQ08"/>
    <dbReference type="OrthoDB" id="15270at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017321">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000246291" description="GPI-anchored wall transfer protein 1">
        <location>
            <begin position="1"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="501" mass="54630" checksum="276B79E50B17C38A" modified="2005-08-16" version="1">MPDTASYKQQKEDFVSNLSGGSVAEINYVTSVAAVAILLWSVLQARQSFFEPYTALAFAVDFLLNVGAILLSVTLYSNSPLLLNLLLIAPAILVFTLPPRSRSPKKKAKIPPNARSNESSGQLDILSTKPFLTNFRGCMLIVTCVAILAVDFRLFPRRFAKVETWGTSLMDLGVGSFVFSAGLVAARPVLREKATGRAGAVGNALSLSSRLVQSLRHSIPLLVLGFIRFLSVKGLDYAEHVTEYGVHWNFFFTLGFLPPFVAIFQSVRKLIPSFAALSLLVGVTYQVLLETTSLKAYVLTAPRTDLISMNREGIFSFVGYLAIFLAGQDTGMFVIPRNLVPKSTASPGAQRNKLLKITAVWGGVWTGLYVLSTNYHYGFGLAVSRRMANLPYVLWVVAFNTIQLLGFAVIDTIFFPAFYNAQDAKTEKEAYTHATSRVMRAYNRNGLAVFLLANLLTGLVNMTVNTLDATPIATMGILVVYSAALTGVAVALDAYNISIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D0J2</accession>
    <accession>A0A0E0RL32</accession>
    <name>A0A098D0J2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG00110.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T00315</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF71957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D0J2"/>
    <dbReference type="EnsemblFungi" id="CEF71957">
        <property type="protein sequence ID" value="CEF71957"/>
        <property type="gene ID" value="FGRRES_15687"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00315"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098D0J2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="953"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1001"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="318"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF71957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF71957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1032" mass="119218" checksum="3C3E147F8335475B" modified="2015-01-07" version="1">MITTLRSYLAIFLQELTDLAGLDDFDEEILRFHSLRHPWQTAVLKWLVSKKENEIWEAALWRDDGEIKRLLEEFEEAFYSSDEMRDLETNPDKEFHSKSRIATAVANNFIHSDEIYFIPPDSSYSQIKFRMETIADQLANTSRELTSKEQAQIRTYEGGTYSILWIAIHRQHLIDVDYLLKNRNIELHTRNGYQQETALHEAVWNRNEQIIESILGSDTSASPSGCVDLCDVLSETPLHTVFKNHALEPFQDTSLEGDRIFRISTVLLDHGANINALNEIYHTPLHLLLQWGYSDAQIGPLLNRFLAEGAEVNSKDFQGRTPLHVACHNNLRQTIRILVEKGADLQTIDHQGQRPKSYLKTSTDNEEFWAGLEILVMTSMAKHRNHMKLPSKSVRIPKRRMDICDKTPVYCRIQRNFRVKDRDSHVSPYWVGTDRYVSDVLYQNAPRHHLTFLQDCERKSRKFWMVIEDHVGKPFDPLTEANVESGQRCYNSWRWVNFPANNMTWVKDFILDHIEQSTSPDSKRVILEFIQNNIRVRDTKERISRIRSPHAQSESLYSRIGNAQNNVMTVLIKQQRLEKHEPKSRSVDSSNMLNAGSMVSIVIPFLDIEVAQPNVWGKSHDRETYLPFTGIDGIQMPQTLDQTFNNVESFSGLRSKENQVIYRWCEKQAPTRWMQFKHPTNRFKRFLLRYWPGYQPDEDPDPGNAAFDYIRQVNEGDKSSNPTRMRSIQQEIQPKWLMVRQLWLWELHDGTILTAIPSRDGKCMADDLLETIQNSELGDIFTSDDLMKHIVQQTVTFTEKFRVAGLGEHILDIFENELASEIDREAGFFNSFTRKDWNSRYVNNAISEAAGCTWRVKDIRGELRLIDKVFTQQLDVLKEFAPVIGAEVGMSPELIKEQEATLIRDSGLEALRERIKRMDEDAATTIDGLSNITQAMLAQASLKEAESARLMNLIILPFTVVTVIFTPLSFMTSLFAVNSDGFPHNNDGELRIPSDWLRNKMIIGEIGTLVPLLILVVSISYLRTGRKNVPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D385</accession>
    <accession>A0A0E0RME6</accession>
    <name>A0A098D385_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T01239</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D385"/>
    <dbReference type="EnsemblFungi" id="CEF72421">
        <property type="protein sequence ID" value="CEF72421"/>
        <property type="gene ID" value="FGRRES_20013"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01239"/>
    <dbReference type="InParanoid" id="A0A098D385"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010018606" evidence="1">
        <location>
            <begin position="23"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF72421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="121" mass="13211" checksum="855E4D3D10213988" modified="2015-01-07" version="1">MTGGVNLSIWVVFITCDDAVNCEHTERRLAIFGCSGDAAIRGDVDNEGEATETLSSKGRYCLLDNVWATAGGNDATIWILSGKFLRYLQANAFIRDGEEDDGSARGDMKDTVVWQMLVAEQ</sequence>
</entry>
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    <accession>A0A0E0RPX0</accession>
    <name>A0A098D4B3_GIBZE</name>
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        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
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    <gene>
        <name evidence="5" type="primary">FG01207.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T02987</name>
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    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D4B3"/>
    <dbReference type="STRING" id="229533.A0A098D4B3"/>
    <dbReference type="EnsemblFungi" id="CEF73295">
        <property type="protein sequence ID" value="CEF73295"/>
        <property type="gene ID" value="FGRRES_01207_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02987"/>
    <dbReference type="eggNOG" id="KOG0419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0895">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098D4B3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23809">
        <property type="entry name" value="UBCc_UBE2Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc_UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000126">
        <property type="entry name" value="Ubiquitin conjugating enzyme, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="3"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="288"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF73295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="446" mass="51153" checksum="12811803CAFC8E04" modified="2015-01-07" version="1">MDQSIIRISKELGDIQKNCDLSIAVACRDVDVRNVKALIMGPHETPYEFGFFEFAIRFHKDYPSKSPTVVCATTNGGRCRFNPNVYSNGKVCLSILGTWRGERGEEWSSAQGLESILLSIQSLLSSNPYENEPGFEDANEESDKKAQKDYVQKIRHETLRISVIQRLEGYLGLSSNGTQQHSTYGAEVEDEDVDEATVPFEPFKDLCKRRFLWYFESYMAAIEKGKSETKPNQPFARMPFESPGNNSMDGKFNYPELERRLHAIKVAIDAEPLKWAGEGLEAKKRDTTVAVNLQHQFEQVVEAFKRSDMPHDVFLENENPFVWVVTYFGRPMTNLDGGLFRIKMNFSVRFPEEQPRVKFETKIFHHHIAADGTACYTPNPAKREDVRSHIEAIFAILEDDEPAYDPRKIVNPEATKMYWGGGADDKKKYNRRLRRSVQQSMEDFPE</sequence>
</entry>
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    <accession>A0A0E0RTA3</accession>
    <name>A0A098D6A9_GIBZE</name>
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        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
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        <name evidence="2" type="primary">FG02219.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T05347</name>
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    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblFungi" id="CEF74478">
        <property type="protein sequence ID" value="CEF74478"/>
        <property type="gene ID" value="FGRRES_20070"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05347"/>
    <dbReference type="InParanoid" id="A0A098D6A9"/>
    <dbReference type="Proteomes" id="UP000070720">
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF74478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="126" mass="14369" checksum="640886C5063ECB50" modified="2015-01-07" version="1">MQKSTNTADEYDLINHKDKPPDHEVIAQLKAAQDLLDNSSVYLTENYSLPTCRVTLPAASVYITNCKTTGDIWLRHIPCNQHDKQLPPAEIITRRYPFVRPQPLTLCFVITTKGVRDSYQIKNSII</sequence>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF76095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DCB6"/>
    <dbReference type="STRING" id="229533.A0A098DCB6"/>
    <dbReference type="EnsemblFungi" id="CEF76095">
        <property type="protein sequence ID" value="CEF76095"/>
        <property type="gene ID" value="FGRRES_17413"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08585"/>
    <dbReference type="eggNOG" id="KOG0911">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DCB6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:intracellular iron ion homeostasis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Monothiol_GRX-rel"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="55"/>
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    <evidence type="ECO:0000259" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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    </evidence>
    <sequence length="89" mass="10385" checksum="E95B55EE45D25B51" modified="2015-01-07" version="1">MPVCRFSRRIVRLLEDHRILYGSFNVLSDEDIRQGLKLFGDWPTFPQLWVNGELVGGLDIVREEFNTKPGYLTEYTVEDNVAFKHGKKI</sequence>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DH79"/>
    <dbReference type="EnsemblFungi" id="CEF77820">
        <property type="protein sequence ID" value="CEF77820"/>
        <property type="gene ID" value="FGRRES_20165"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12033"/>
    <dbReference type="InParanoid" id="A0A098DH79"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="61" mass="6996" checksum="E7F9EB0BB1092F8F" modified="2015-01-07" version="1">MDAHSFDRLGSRRSIMIVMSLLVMLGVSIHVYALLFLPSYKLPSIASTQEYFTSIEMRSER</sequence>
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    <accession>A0A0E0S5L2</accession>
    <name>A0A098DK02_GIBZE</name>
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        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
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    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T13969</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DK02"/>
    <dbReference type="EnsemblFungi" id="CEF78787">
        <property type="protein sequence ID" value="CEF78787"/>
        <property type="gene ID" value="FGRRES_15215"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13969"/>
    <dbReference type="InParanoid" id="A0A098DK02"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF78787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="59" mass="6444" checksum="920E4C441DBA506D" modified="2015-01-07" version="1">MIVKVYLKPFVAELSSATSSIHLPFAYKSKKILTLTTDSAHEILVMVNVSDALRTGYSG</sequence>
</entry>
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    <accession>A0A098DL75</accession>
    <accession>A0A0E0S883</accession>
    <name>A0A098DL75_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
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    <gene>
        <name evidence="3" type="primary">FG04660.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T15819</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
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            <taxon>Sordariomycetes</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A098DL75"/>
    <dbReference type="STRING" id="229533.A0A098DL75"/>
    <dbReference type="EnsemblFungi" id="CEF79708">
        <property type="protein sequence ID" value="CEF79708"/>
        <property type="gene ID" value="FGRRES_04660_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15819"/>
    <dbReference type="eggNOG" id="ENOG502QWMA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DL75"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="196"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF79708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="684" mass="77192" checksum="F15F72975D418C5E" modified="2015-01-07" version="1">MKPQDLVCNKCWDEFFNTESFEKTCTAEDDPYIHHETEAVSTIDEITNASSSGCNWCSFVETFLYDSKHGKTRIKTVLLPGRERHQATPRGRNVFFVRVYYLCGDEEEFADTRRIYAFTSSKDEASAHVTARPLRHDVGSPEGNLQMQSWLAECKGHEGCLDPHAEATLPTRVIEVRPKDQNEPRVVESGGRRGRYATVSYCWGKAPFDTLNTSNYAQFMEGFDNRTLPLTFQQAIAVTRSLSIPYLWIDALCIIQDSEKDKNREISSMKDIYASSTLTIVAASAQEVSEGFLQDRPHIKQSFTIPFCLKPNVFGTFSFGSLDDASYDERSEPLAKRAWTLQEQLLAQRTITFASHTMMWACKAGTKTFGDSFHYPFYDSMDTYTSLNLNELLMDDQDALAVKYEALTCWSRLVSAYSLRRASLENDKLNAVAGIALHGSFAPALGPGYYAGLWTYKLALQLTWYVSYHHRSLPDGEKLDSYRPKTYRAPSWSWASIEGGMIQFDEVFAPIYNTAPICKVLDCSTTPKLAQNPFGEVVAGQLKVLGFVRTAWFYPQTSNLVLLPMSNAEGGDESIMSHEEGYNKYIEDFIAANPNVDFKEDPEVLHGTWNNNTSGTRDETRFTEPMIVFCLAIASEGFTGKGISGLLLTRTDNASPYTRVGQFMRGRKRDFRNKELVAEELIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DLF1</accession>
    <accession>A0A0E0S6Y7</accession>
    <name>A0A098DLF1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG04285.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T14921</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DLF1"/>
    <dbReference type="FunCoup" id="A0A098DLF1">
        <property type="interactions" value="849"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A098DLF1"/>
    <dbReference type="EnsemblFungi" id="CEF79262">
        <property type="protein sequence ID" value="CEF79262"/>
        <property type="gene ID" value="FGRRES_04285_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14921"/>
    <dbReference type="InParanoid" id="A0A098DLF1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF79262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="219" mass="23988" checksum="00CEA495FE429996" modified="2015-01-07" version="1">MSGAADREAVFPTRQSLGIMKAKLKGAEIGHSLLKRKSEALTKRFREITKRIDEAKRKMGRVMQIAAFSLAEVTYAVGGDIGYQVQESAKSARFRVRTKQDNVSGVLLPAFESYLTEGNNDFGLTGLGKGGQQVQRCRETYARAVEALVELASLQTAFVILDEVIKVANKKQRDTAAADAEMKARREKEAAAQSGQTSQKNDDAPTDVLGENDDEDVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DMK2</accession>
    <accession>A0A0E0S865</accession>
    <name>A0A098DMK2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T15783</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DMK2"/>
    <dbReference type="EnsemblFungi" id="CEF79690">
        <property type="protein sequence ID" value="CEF79690"/>
        <property type="gene ID" value="FGRRES_20217"/>
    </dbReference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="71" mass="7943" checksum="DF8A29097C77964D" modified="2015-01-07" version="1">MKQWLHRIGQSEQKAKEAHVLSLSPFSEPTVNAPVFHGRQAFTPRRISSCPKRGFESTTGGDKPQLYGYIG</sequence>
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    <accession>A0A098DNG6</accession>
    <accession>A0A0E0S8X9</accession>
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            <fullName evidence="2">Chromosome 4, complete genome</fullName>
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        <name evidence="2" type="ORF">FGRAMPH1_01T25835</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF82892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DNG6"/>
    <dbReference type="EnsemblFungi" id="CEF82892">
        <property type="protein sequence ID" value="CEF82892"/>
        <property type="gene ID" value="FGRRES_07859_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25835"/>
    <dbReference type="InParanoid" id="A0A098DNG6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="27"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="325" mass="37117" checksum="AEFE7ABEDE545094" modified="2015-01-07" version="1">MSVSEFKAPGLLMTILSATALLIAVLYRGYRTRRFYRDLISKPSPPHSWLLGHISILKNIALSMPRNSMPQLYYTEIAHRYKHEGIFYLDLWPIGPSLVIITDPKLIEQAHIPRPMVPHPFTNTSMAPIAGDDIIPTKSGTEWKKLRNDMSPAFSYTYAHNMVGVIVNESKLLRGKLDELSATGQVFSMEELLNKTIFGTVSRHLLNDESYAQKAGRQDLADMRELIDLAREESDPRIAYNPLVQIPRRMKRYIIRRRLEASLFGVIYKRLETLVSGGIVPSRQTPTSVLDLILREHAELAKRENKEGRCNFANLSKFEEKQLLT</sequence>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DNY4"/>
    <dbReference type="EnsemblFungi" id="CEF83074">
        <property type="protein sequence ID" value="CEF83074"/>
        <property type="gene ID" value="FGRRES_15443"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25433"/>
    <dbReference type="InParanoid" id="A0A098DNY4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF83074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="62" mass="7056" checksum="89FF9CD20E184CAF" modified="2015-01-07" version="1">MARGKTILRFRLSDDLSITKIRNNIGNVLQTPTSTESHNLQVQVELPSCPRITVLKKLQRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DS24</accession>
    <accession>A0A0E0SB20</accession>
    <name>A0A098DS24_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG07863.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T25843</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DS24"/>
    <dbReference type="STRING" id="229533.A0A098DS24"/>
    <dbReference type="EnsemblFungi" id="CEF83633">
        <property type="protein sequence ID" value="CEF83633"/>
        <property type="gene ID" value="FGRRES_16912_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25843"/>
    <dbReference type="eggNOG" id="ENOG502SG5D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DS24"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12193">
        <property type="entry name" value="bZIP_GCN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF83633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="317" mass="34821" checksum="1FD75E980D678C41" modified="2015-01-07" version="1">MFNSSEMPFKRFIILAKGEPFEGRLLKGAGCVAKWMIDKRVDRDNSRGGRRPLNLNQWQQRVHPPPPAASPRPCPGSLLAAPASLPSNDLGIDPGLLLFENYSPYLEFLPADYNGFDGATWDFGNIANNNNTTAATNDNDVQNFSGDGLFDNIMIPELNVLDTQSSLDVVGDGFLSQEQPLLTVNSTTPIEYPATASSSSSTPHPPPTIRTKSPTSTSAIPGTSTFSLHPSPSSSSSSSSSSSRKRKSSPEEEDSAVTLKRQRNTLAARKYRQKRIDRITELEEALAAKAKECDDWKLKFMRKEAENDTLREMLAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DTU0</accession>
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        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
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    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T25515</name>
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    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DTU0"/>
    <dbReference type="EnsemblFungi" id="CEF84777">
        <property type="protein sequence ID" value="CEF84777"/>
        <property type="gene ID" value="FGRRES_07731_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25515"/>
    <dbReference type="InParanoid" id="A0A098DTU0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF84777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="409" mass="45807" checksum="16353DDD99261290" modified="2015-01-07" version="1">MFQLRKRLLYKSEGHNHSDNQASSDDKTKSGDHRDKSTVKPLTATVANISSLRTLRSVAMTSQKASPDHGHLSTVSAPTRSYKRLGTSSPLFSVKRRRTNLPSHAPSPIMASVAVASRSSPLPLSTRPTTPASHSSPKDTKTPPKIGYALPKSVFEDLDDDQQSLVQRKGSSRDLSAQAMMAKGHKVQHKLRAAQSNLERSRINLEIAQDELTQAKTAYHNWRADIFAETEKATTIRESLQLVKRHKKHYAFLQTLVKGGPLMTERLIGAAKDAGLKFETGLDFVYLEMIVCVMLSLAQHRRDDLDPSRSMNYRVHLLVSKKGDTTHAHVFDAEFPKSVLDELDEPSHHEKATWPAIYHTRVPYEPYDTFASRITSHLVRDKHSLRIKEAGTGSQCIPKKRKFGQELPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DV25</accession>
    <accession>A0A0E0SFJ4</accession>
    <name>A0A098DV25_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG07084.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T23921</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A098DV25">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A098DV25"/>
    <dbReference type="EnsemblFungi" id="CEF85207">
        <property type="protein sequence ID" value="CEF85207"/>
        <property type="gene ID" value="FGRRES_16775"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23921"/>
    <dbReference type="eggNOG" id="KOG3613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DV25"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056459">
        <property type="entry name" value="TPR_DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056458">
        <property type="entry name" value="TPR_DOP1_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24601">
        <property type="entry name" value="TPR_DOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24597">
        <property type="entry name" value="TPR_DOP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="8">
        <location>
            <begin position="40"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like middle TPR" evidence="9">
        <location>
            <begin position="394"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like TPR" evidence="11">
        <location>
            <begin position="1019"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="10">
        <location>
            <begin position="1367"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF85207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1868" mass="206959" checksum="C2DB7F111F9517D4" modified="2015-01-07" version="1">MTLEPGSGRRSVSPESSGRDSPIPRQWRNQLGEEDYAIKDKSYRKYAHGVDRALVLFETALEEWADYISFLNKLLKALQARPKSVNAIPSKATVAKRLSQCLNPSLPSGVHQKALELYNLVFSVIGKDGLSRDLPLYLPGLATVLSFASLSVRAPYLDLLERHFLGIDPRSLRPAMKSMILALLPGLEEETSEDFERTLRLVESFKHAIRPLYSEEITEQHSSGDTFFWQCFFLASITSQSRRSGALAYLIRFLPTLGPQATPEDKTAQSSTNEDTQSKLATVVTSPEPGLLLRCFASGLSDEQLLIQRGFLDLLVSHLPLNAHVIQSRVKLDDLELLLKAAVGVVTRREMSLNRRLWAWLLGPEPITEHDRSGETPGSPPADQHSFAAARTHYFEDFGLRPLTRSILQMIKSSSHNAASERAKPYRICLSLMDRWEIGGLVVPEVFLPMIESVRHFKDHASSKSEFNEILPSASTFFDGIESGLIYGEIAGLLAQALGPGSLSAHERKDKLSLVSFILANFNVREEEMVTIHAPLCCLTALAMLGDFKERISTHGSADSQLLSLSSQAQSVALSLLDLIPERVFPDITEDLKNKRSSSTLPSNDEILKKSQNFYVNEQGNIEASPPPFSASTIGQTILDKAAQFVCQDLGSSETDLNACVRLLVHAVYKTPKTYQVKGKQLLELMHDLLEQPDIMAFPSFSAILQLSTQLYDAERIETTQLSSLIPLLVRHAWAYLSASEPKYHVEAVRGLWQLQSALSTSNRDIEAALSSLIIAQDTSRFRGAEPVDKGRALSVLWSHTLQDNAPAERRGSKTPVHDIKSLPRLAGADNYEVMLTQPIFLILDALEDDRTQLYMTVKSWLNTMLGIDRLFLIFVSKLSEIPFLQTLAQNDVKNDQVSTTFSESEDLDLALYYLRTLSNILACAGEISWTVLVSKHVSFHGHHIQISSGGEEHEMTLQEFFVNACMRCITTNPTETATQGSDDRVNQLYRYALSLLHKFLNSPFAAHLSAQHLENVLIERLEKSLQGSDAYVQVLLLDVVYDTLKLRDIAPIEAPASPISERRMSSFDPRGSRPSLSAPEVRQIMTPPPQLLQCLQDGLSSPSSRPVLDSWVAFVSECLPLYSDSIFQVVIPLVETLCKEIDITFANLRGTFYSSSLSIGGEKQSPESTLIFLLNGLEQVLARAHQRLLNEEARTQVVKGPDQPQSLFGSMVSNVWQSDNTQSRSATANDRLTVHLAFQDAVRICYKIWTWGQGDDSSRQDQGSFGSFNYTSLRMRNRSRRLLEHLFAAESLECLETVIASWKQSTEEGEPTQVFNMLSALEACRPKHCIPALFGAIYRRTSAGNADLTSKSTMTISLQDTDLVKFLVEYTKTLDDDAMDEIWQDCMAFLKDLLTNPFPHRQTLPNLLEFAALLGEKVDNTNFGEQRRMRKELGDTFIRLLAALFTTRPIAFADPAMSSGGIPKSDSGNTINGYGDGPDDVVSILAGIVPKLAKILVEPDRVLSASATISANVIGPTLRAKGFPEIVTENTTRLLHELSRVENNQKNWKKDVGDAFNDVKFFGMDLDLVKDDWLPLLKQWTFTDKEKMSEIVSRINAPSTAGIVFGVGATSARLEADRKTQLNLRRIATLILAGSEDAFVSDLSDIFGKLAELLGASSTSSPSSTTRADIYMVFRALALRTSAIHLGMLWPVVNAEIHAAISSVAAADNSAASDTYTNASVLQACKLLDLLICVAPDDFQLHEWLFITDTIDAVYRPSTYQPVALVDELSDELGATATASKFHSSSVVNPVVQGSSRRPLLGPGGINDDVSLERKDELVVKVLRPFFGQLSIFAFESTYAMGRVDREVCVSSLLKDLFDEQSIVRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DWE6</accession>
    <accession>A0A0E0SGW1</accession>
    <name>A0A098DWE6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG06607.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T22693</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <location evidence="1">Endomembrane system</location>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="229533.A0A098DWE6"/>
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        <property type="protein sequence ID" value="CEF85674"/>
        <property type="gene ID" value="FGRRES_06607_M"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22693"/>
    <dbReference type="eggNOG" id="KOG4504">
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        <property type="component" value="Chromosome 4"/>
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        <property type="entry name" value="Man-6-P_rcpt"/>
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        <property type="entry name" value="MRH_dom"/>
    </dbReference>
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    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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    </evidence>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="FGRRES_15286"/>
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</entry>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098E0M0"/>
    <dbReference type="EnsemblFungi" id="CEF87651">
        <property type="protein sequence ID" value="CEF87651"/>
        <property type="gene ID" value="FGRRES_16482"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17891"/>
    <dbReference type="eggNOG" id="ENOG502QT51">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098E0M0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="928"/>
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            <begin position="222"/>
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    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="EMBL" id="CEF87651.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF87651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RMD6</accession>
    <name>A0A0E0RMD6_GIBZE</name>
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        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
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        <name evidence="1" type="ORF">FGRAMPH1_01T01219</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
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        <citation type="submission" date="2017-01" db="UniProtKB">
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                <consortium name="EnsemblFungi"/>
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        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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    </evidence>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="229533.A0A0E0RNG7"/>
    <dbReference type="EnsemblFungi" id="CEF72792">
        <property type="protein sequence ID" value="CEF72792"/>
        <property type="gene ID" value="FGRRES_15780"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A0E0RNG7"/>
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        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </evidence>
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    </evidence>
    <sequence length="337" mass="36841" checksum="1199195F161600DE" modified="2016-04-13" version="1">MLLSTRFQARALRQLISKQPSRSISTSAAKSLLITPSTQLTAKSLTTFNSSTPRSASFATSAEATAEPVNTNFAAVSTGGIPYPGIPNIEDPYKKRQWQLEHMAGAFRVFARMGFTEGAAGHISVRDPVDRNTFWINPMGVHFGMLKASDMVHINEDGQVIGGNRVAVNAAGFTIHSAIHKARPDVDAACHAHSKYGKAWSTFGKPLDMISQDACIFYKDHSVYSDFGGVVFEDDEGARIAQALGPKNRSVILQNHGLLTAGGTVDEAAYLFSLMERTCEVQLLVESTGLPRNTISDEAAEYTYRYNADPNTLYTEFQPDFEYEVWKSNGELQSGVN</sequence>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
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                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
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                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
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                <person name="Mauceli E.W."/>
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                <person name="Nelson D."/>
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                <person name="Qi W."/>
                <person name="Quesneville H."/>
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                <person name="Waalwijk C."/>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
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                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
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                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
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                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
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                <person name="Ruiz-Roldan M.C."/>
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                <person name="Yoder O."/>
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                <person name="Zeng Q."/>
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                <person name="Galagan J."/>
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            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>PH-1</strain>
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        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
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            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
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        <property type="protein sequence ID" value="CEF76501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="FGRRES_17079"/>
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    <dbReference type="eggNOG" id="ENOG502STMR">
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        <location>
            <begin position="1"/>
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    <feature type="chain" id="PRO_5010027125" evidence="2">
        <location>
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        <location>
            <begin position="63"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF76501.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF76501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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    </evidence>
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<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0S1J9</accession>
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        <name evidence="9" type="primary">FG08906.1</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="229533.A0A0E0S1J9"/>
    <dbReference type="EnsemblFungi" id="CEF77374">
        <property type="protein sequence ID" value="CEF77374"/>
        <property type="gene ID" value="FGRRES_16947"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11143"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A0E0S1J9"/>
    <dbReference type="PHI-base" id="PHI:1215"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF77374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="732" mass="80776" checksum="86DF460D13BC8E0F" modified="2016-04-13" version="1">MSTRTLQLPQSKLSLPADVFLLVSSTDKSTSPSPLRANQFQTSFSPRDISTDLTESIVLEEGGESGSETLEPVTPVSGRHSQDFTLESQDLQDLQSLQSYPAGSVTSSGVGPIAIPGANAGNNNKGGYLSQSASRPPTTPTTPRASEPEPGTSLTRQSTRGSISTASFKRTMSSFFRRSNSQARNDYTPSEPPTPSVVSAPTEPQTNGQPRAAARRRFSMNRSSATTRSNSPPSPSDNGLEMNLPHRERGVDKSLPSQGDFKKHRASTGFTLRNRINFVGANPNGRGNGNKRPEYNRRASSYDGSRPSTPLPPPVEGDETMYPPERSVWPLPPESGTGAKARRMSLSLPDDFAVDVAELQNEFEYQRKFLGRHGKHLGKGAASKVTLMMRKGYPEELYAVKEFRGKSHRESQQDYENKIKSEFSIGKSLHHPNIVETFRLCTDHGRWNHVMEYCSEGDLFSLVQKGHLKGDDRKKDRMCLFKQLIQGVYYLHVNGIAHRDIKLENLLITKDSKLKITDFGVSEVFCGTHPGLREAGGQCGRNMGGEIRLCSPGICGSEPYIAPEVLAKKESYDPRALDVWSSAIVMIYLTFGGAIWSRAEPGELHYDKLVTGWNKWYAKHPENDASISDSDYPKCYALDVGMSPPALRRLVLQMLNPEPSKRISIDEVINNRWLKNVECCQLESYDDPALLIDATKKDNSIQGNKKIFCHNHLPPKGTGSHSLGKMPGQAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0S5G5</accession>
    <name>A0A0E0S5G5_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T13877</name>
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    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0S5G5"/>
    <dbReference type="STRING" id="229533.A0A0E0S5G5"/>
    <dbReference type="EnsemblFungi" id="CEF78740">
        <property type="protein sequence ID" value="CEF78740"/>
        <property type="gene ID" value="FGRRES_20183"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13877"/>
    <dbReference type="InParanoid" id="A0A0E0S5G5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055481">
        <property type="entry name" value="DUF7053"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23155">
        <property type="entry name" value="DUF7053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7053" evidence="1">
        <location>
            <begin position="3"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF78740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="194" mass="21872" checksum="47F97CB14561E13B" modified="2016-04-13" version="1">MRSQHHSTVTIPIPRHIPPQVVLDYLQTYEPVLRHNPGMVSWTPSTLNYETVIHDTFFDASDPNQSLRCFEAYEIIRLGPGVGRDCRWPIIFQRVPNGIVSRADAPAKVISWTQWYVRARQNEQESTNISTPSTATPSSNGDEEWELYGIVTLEAHRMLIPWCRRSTGLYQEAIGQGIVDDVCSKHAAASGVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0S7B0</accession>
    <name>A0A0E0S7B0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
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    <gene>
        <name evidence="4" type="primary">FG04389.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T15169</name>
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    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0S7B0"/>
    <dbReference type="FunCoup" id="A0A0E0S7B0">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A0E0S7B0"/>
    <dbReference type="EnsemblFungi" id="CEF79385">
        <property type="protein sequence ID" value="CEF79385"/>
        <property type="gene ID" value="FGRRES_15019"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15169"/>
    <dbReference type="InParanoid" id="A0A0E0S7B0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF79385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="59" mass="6624" checksum="8AE6546F3950D98B" modified="2016-04-13" version="1">MARGNQRDKAREKNLKNKPQDKANKMSGTQMQHAKESNADIMRQKQAAAEARKAAEGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SCP7</accession>
    <name>A0A0E0SCP7_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">N-glycosylase/DNA lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">FG07050.1</name>
        <name evidence="16" type="ORF">FGRAMPH1_01T23831</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SCP7"/>
    <dbReference type="FunCoup" id="A0A0E0SCP7">
        <property type="interactions" value="619"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A0E0SCP7"/>
    <dbReference type="EnsemblFungi" id="CEF84210">
        <property type="protein sequence ID" value="CEF84210"/>
        <property type="gene ID" value="FGRRES_16767"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23831"/>
    <dbReference type="eggNOG" id="KOG2875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0SCP7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000006">
        <property type="entry name" value="N-glycosylase/DNA lyase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000005">
        <property type="entry name" value="N-glycosylase/DNA lyase OGG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="15">
        <location>
            <begin position="131"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CEF84210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="396" mass="45312" checksum="C5D5A5340535D056" modified="2016-04-13" version="1">MSIVGKTEWQKLPVTLKELCINTTLRCGQSFRWQKINHEWTCTLHGRLLHLKQDSAHLHYRITYPAPKPTTPEPKDTESLLRHYFNLDTGLESLYKQWSEVDSNFRKRAPQFQGVRILNQDAWETLIGFICSSNNNISRISQMVHKLCRHYGPFIAYIGDEAFHDFPSPQALTGDSVEAHLRTLGFGYRAKYIAETARIVANEKPETWLESLRNPEHPGFNTTPVPREQHATYKEAHQQLLTLKGVGPKVADCVCLMGLGWGEAVPVDTHVWQIAQRDYKFGKSKVKTLNKATYDAVGDHFRNLWGSYAGWAHSVLFTADLREFAAQAAKEEDEPTMIKIEVASSQEHTLKRTKKTITITDSNTEVKEESPIVIPKDEQGVEEVKQMRRSKRLRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SJV2</accession>
    <name>A0A0E0SJV2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG06169.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T19661</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SJV2"/>
    <dbReference type="EnsemblFungi" id="CEF86715">
        <property type="protein sequence ID" value="CEF86715"/>
        <property type="gene ID" value="FGRRES_20293"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19661"/>
    <dbReference type="InParanoid" id="A0A0E0SJV2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF86715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="68" mass="7334" checksum="D01CE54E7E263C4F" modified="2016-04-13" version="1">MLKAYKNLSSKTRLGVGVAVIAWGAAGLMLTDPLEKSLGLTPTEEDKAELDKYTPKIVTVVKDEKDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SKD7</accession>
    <name>A0A0E0SKD7_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Queuosine 5'-phosphate N-glycosylase/hydrolase</fullName>
            <ecNumber evidence="6">3.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 6">Queuosine-nucleotide N-glycosylase/hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T19327</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:75387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:194371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5 6">
            <dbReference type="Rhea" id="RHEA:75388"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the QNG1 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="6"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SKD7"/>
    <dbReference type="STRING" id="229533.A0A0E0SKD7"/>
    <dbReference type="EnsemblFungi" id="CEF86900">
        <property type="protein sequence ID" value="CEF86900"/>
        <property type="gene ID" value="FGRRES_16592"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19327"/>
    <dbReference type="InParanoid" id="A0A0E0SKD7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019438">
        <property type="entry name" value="Q_salvage"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314:SF0">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10343">
        <property type="entry name" value="Q_salvage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF86900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="365" mass="42331" checksum="A2B67984EAD862B7" modified="2016-04-13" version="1">MSDDEVDTELLELLRQHLQGKVEIQDEPETGVLQSAEHVYDSCIDVAVDMRASKKAAENIYNQMQQKSYSTATWSEHELHPKAKDESTVNFIFTMDLLNFSFWSELPDDERFAIEYRGKKWTGYWSLVAALQRALDENIPITDPFYWQNEQECTLESLRHVFRSCTEEDIPLLEERLDCLREAGQVLCKYYDGAVTELVYAADGSAARLVNLLAQDFNCFRDEHRYEDGKMIRLMKRAQILVADLWACFNGESYGEFRDIDKITMFADYRIPQILMTMGALYCSPSIAAAINDKKMIESGCAWELQIRACSIWCVELIRREILRQHPGAHVNAILIDFFLYDSMKELEAAGKEPIPHHRTRSIWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SMV1</accession>
    <name>A0A0E0SMV1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T18439</name>
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    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SMV1"/>
    <dbReference type="EnsemblFungi" id="CEF87764">
        <property type="protein sequence ID" value="CEF87764"/>
        <property type="gene ID" value="FGRRES_15310"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18439"/>
    <dbReference type="InParanoid" id="A0A0E0SMV1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF87764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="58" mass="6278" checksum="09CAAC23F5168E75" modified="2016-04-13" version="1">MEAGKSTETGVLFDFRHWIGGFSNTQEVAIDGFQQMASSIPVCSSMIGSCAAIRIEQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SPL6</accession>
    <name>A0A0E0SPL6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T18981</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SPL6"/>
    <dbReference type="EnsemblFungi" id="CEF88379">
        <property type="protein sequence ID" value="CEF88379"/>
        <property type="gene ID" value="FGRRES_16564"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18981"/>
    <dbReference type="eggNOG" id="ENOG502RQ3U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0SPL6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="84"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF88379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="412" mass="47108" checksum="AAA9620B9B60D43D" modified="2016-04-13" version="1">MSQDLADANVTIARLDEKYHDLEESMERHIISLRGEIKNLKLEHSQCADVAMLVNDLKERVDRLSTESTTNDVLMKNYKLHITISELQDEMQEKKKDISKLTKENRELHQVMDQQRIEIDNLERELEDVQDENFGLTHAQDDMSHRIQELSKENDRLEKRLLRRREIRSIFKALELPRLPFKWQNNNFLFSYIIQAPHQQPSLDPYIDTNDEGHHSEVVQPAAQVGECAPEEITQPAQNTAHQDSHATGPSDNVNTWANQPPHGPRYGPWRRPYYDSYRPPRDITMVDSMVLQSVGRAGSRAPPGLAIHSNSRGGGIQQDVFTKVPSSSKTIAFRVESEETLIQAYRQVKSMNPSASVGGIMFSVAPKADSPFTEIDNIRWGSLTGRRSFSSRFTTAAARSFRNGRSWTFDV</sequence>
</entry>
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    <accession>A0A0E0SQ30</accession>
    <name>A0A0E0SQ30_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T17691</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SQ30"/>
    <dbReference type="EnsemblFungi" id="CEF88543">
        <property type="protein sequence ID" value="CEF88543"/>
        <property type="gene ID" value="FGRRES_17663"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17691"/>
    <dbReference type="eggNOG" id="ENOG502SN24">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0SQ30"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF48">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF88543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="272" mass="31287" checksum="457AD3D1244D384B" modified="2016-04-13" version="1">MTLQTPTIAEVRASSEVLSTPGASATVVKVGEHFAVKFGRTVTLQEAENLRFMSADSKVPVPKFYKTMAEPETGINFIVMEYIDSKTLAEQWPSLEASEKLEIADQLRVILQDLRSLEPPSYLGSLNRKPLQDRIFLTPEQNAATSGPFDTEDDLNEGILKRLSENESQEHVAFLRKLMIETLHDHQVRFTHGDLQAKNILVKKIELGESKRFEIKLIDWKISGWYPEYWEFCNSTIASRFRSEWLEMAQNIMQVYVPEYLMLQIIRSHLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YHG7</accession>
    <name>A0A1C3YHG7_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FGRAMPH1_01T00477</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the methylcitrate cycle that catalyzes the synthesis of (2S,3S)-2-methylcitrate from propionyl-CoA and oxaloacetate. Plays an important role in detoxification of propionyl-CoA, an inhibitor of both primary and secondary metabolism. Also has citrate synthase activity using as substrates acetyl-CoA and oxaloacetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>propanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-methylcitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58853"/>
            <dbReference type="EC" id="2.3.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB63997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YHG7"/>
    <dbReference type="STRING" id="229533.A0A1C3YHG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00477"/>
    <dbReference type="eggNOG" id="KOG2617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YHG7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050440">
        <property type="term" value="F:2-methylcitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF15">
        <property type="entry name" value="CITRATE SYNTHASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SCB63997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="472" mass="52089" checksum="2D28D94F5BCD08A3" modified="2016-11-02" version="1">MALNLTTSRRALSSLKPLTRAAFVGARGYATAEPDLKATLREAIPAKRELLKKVKAHSNKVLGEVKVENTLGGMRGLKAMVWEGSVLDANEGIRFHGRTIKDCQKELPKGKTGTEMLPEAMFWLLLTGQVPSVNQVRGFSRELAEKAQIPEFVSKMLNDFPKDLHPMTQFAMAVSALNYESKFAKAYEQGINKADYWEPTFDDCISLLAKLPTIAAKIYQNAYRGGGALPAEVDLEQDWSYNFAAMLGKGGKENENFQDLLRLYLALHGDHEGGNVSAHATHLVGSALSDPFLSYSAGLQGLAGPLHGLAAQEVLRWIIQMKEAIPSNYTEQDVNDYLWSTLNSGRVVPGYGHAVLRKPDPRFEALMDYAAARPEIANDPVFQLVEKNSRIAPEVLKKHGKTKNPYPNVDSSSGVLFHHYGFHETLYYTATFGVSRGLGPLAQLIWDRALGLPIERPKSINLEGILKQVEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YHK0</accession>
    <name>A0A1C3YHK0_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytidine deaminase</fullName>
            <ecNumber evidence="4 13">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 13">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FGRAMPH1_01T01071</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2'-deoxycytidine + H2O + H(+) = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>cytidine + H2O + H(+) = uridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="4 13"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YHK0"/>
    <dbReference type="FunCoup" id="A0A1C3YHK0">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YHK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01071"/>
    <dbReference type="eggNOG" id="KOG0833">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YHK0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000069">
        <property type="entry name" value="Cytidine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="27"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="68"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SCB64053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="165" mass="17617" checksum="5ACE6B433A7889C7" modified="2016-11-02" version="1">METPETITRGDTAKTAEVCKAHGISPEEFSELRTRATAAKATAYCPYSQFRVGATVLSSEGKLTSGANVENASYPVGTCAERVALGTAVTSGHRGFRAIAVATDIAPPASPCGMCRQFIREFCKLDTPIIMFDKNEDFVVVKLEQILPMSFGPDQLPRPGAAVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YIN4</accession>
    <name>A0A1C3YIN4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T05331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YIN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05331"/>
    <dbReference type="eggNOG" id="ENOG502SRX7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YIN4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028116">
        <property type="entry name" value="Cis-CaaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14832">
        <property type="entry name" value="Tautomerase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase cis-CaaD-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="175" mass="20143" checksum="C80A8B72C457AE3D" modified="2016-11-02" version="1">MPFYQIHHSCSLNQNQRQLLATAITQLHCRAFETPSFFVHVRFYPEENKDNNYFVAGWPHPATSNRIVGLVRDSASRSKADFDKLATDIEEYWYSVLGVQPPAKKSRWNVGDEEKRLIMVTFTPMLALREGGMTIPEAGKEEDWLQEQLPYIDSMRVKGIEGFPGLYNDAKNSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YIX7</accession>
    <name>A0A1C3YIX7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FGRAMPH1_01T06779</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YIX7"/>
    <dbReference type="FunCoup" id="A0A1C3YIX7">
        <property type="interactions" value="379"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YIX7"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06779"/>
    <dbReference type="eggNOG" id="KOG2276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YIX7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017153">
        <property type="entry name" value="CNDP/DUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037242">
        <property type="entry name" value="CNDP_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="10">
        <location>
            <begin position="276"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="9">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SCB64507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="536" mass="59308" checksum="1E7EA9BBE7B91BE5" modified="2016-11-02" version="1">MPRTFHLNRAAVCCAQVVTAFPKRPFLSLRVPISQSFSKKLNLTSRTYLTDSIRVHQAKKMAPQLDGFFKQVDSSADHFIERLRKAVAIPSISAEDARRPDVVRMGEWLGDELKALGASVELRPLGKQPHKEHLDLPPVVLARYGNDKNKRTILVYGHYDVQPAEKSDGWATEPFDLTVDDKGRMFGRGSTDDKGPVLGWLNAIEAHQKAGVDFPVNLLMCFEGMEEYGSEGLDDLIKEEAKKYFADAEAVCISDNYWLGTEKPCLTYGLRGCNYYSVEISGPGADLHSGVFGGTAQEPMTDLVRVLGSLVNTGGEIQIPGIKEQVAPITVDEEGLYDGISFTMDNIHESLGSKTTIFDDKKRTLMGRWRYPSLSIHGVEGAFSAPGAKTVIPAKVIGKFSIRTVPDMDIDKTNEAVYKYVEDQFAKLGSKNTLKVYAQHTGKWWVASPKHWNFSAAAKAVERVWGVEPDYTREGGSIPVTLTFEEATGKNVLLLPMGSSTDGAHSINEKLDKRNYIEGIKLLGAYLHYVAEEPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJ45</accession>
    <name>A0A1C3YJ45_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FGRAMPH1_01T05607</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJ45"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05607"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJ45"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF305">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="237"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SCB64405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="431" mass="45084" checksum="57D5311B48086A5C" modified="2016-11-02" version="1">MTTIRPAATDHSQDNPLVEDEVPDHATSAIPDGGYGWTIVASCFILLFWINGYTTAWGVLQAAIVQSPRLHTNIRTITFVGSLYMACMVAFGLASVRLSRQFGIRFTSLTATILFGAGLIITSFTLEHLAGLFCVAGLLVGLSTSLLYTATNTLPVQWFSSKLGTANGIVKAGGGVGATVLPLATQAMINKVGLQWTFRILGFSILATGIPSALFLKDFVRNSSTSRFDWSQLKSIPFLTLAMAGAVGVFALFVPPFFLPVFARSIGLSASTGAGLVAGFGASTAVGRFAGGWICDRIGAFNALALAASINSVSMLAIWPVSSSLPPLFVFAIINGCANGSFFVALPTAVATLAPGSAAASISLMTSFWTPGYLMGAPIAGILIDSQHASEASSIEPYRAAIFYAAGVGSLATLLVIVSRMTLSRKLVKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJ76</accession>
    <name>A0A1C3YJ76_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T07393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJ76"/>
    <dbReference type="FunCoup" id="A0A1C3YJ76">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YJ76"/>
    <dbReference type="eggNOG" id="ENOG502RXXJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJ76"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="SCB64559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="216" mass="24089" checksum="47FA46F714E2FF0B" modified="2016-11-02" version="1">MPLIAEQRKMAAPGKTFIVEHLDPELGPWSELEYLAIARETQDTRGSFILSSLPSTFKVPADLASNPAFTAEQRGVEELYAANKSKVCLLDPSAAKDLSPEDGETFDAFLFGGILGDDPPRDRTSELRKKGFEGRRLGPKQMTTDTAVRVTRIVVQDKVPVDQVPYLDFPELKFNEHESTEMPFRYVKGEDGKPIMPKGMVELIQKDSDKAVNDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="12 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJL6"/>
    <dbReference type="SMR" id="A0A1C3YJL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17781"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJL6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative ferric-chelate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
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        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF24">
        <property type="entry name" value="REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
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        </location>
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        <location>
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        <location>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SCB64747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="585" mass="65804" checksum="E620DBF8C95D351D" modified="2016-11-02" version="1">MSSGNSLLPRGGYELTPEQQALKDIAETTNGNLAKYLMIVCGSVSLAVVIWKVCERIIRLTRHVSCLNNDKQRYFAIPSQRFASLKRNLLYAPVFSKRHNREIQISKAINVGTLPTRFQLLFLIAYFASNIVWCVIDIDYSADMSAACGVIRNRTGVLSTVNMVPLFLLAGRNNPLIPLLNISFDTYNLLHRWFGRIVVLEALAHTISHYGKNGWVFTPPAGNFILPGFIATCSFVFLMIQASSPLRHGFYEVFKALHILAACAAVVGLYYHLSASPQLYKWLCYVYGVIVLWSFDRTSRMWRILRSHVGGSRSRTIVEALPGNAVRLTMTLARPWKAAPGQHAYLYLPAISYWQSHPFSVAWYDGVEDPKNERLASTNQDLLAMQQQRISFVIRGRTGMTDSLYKKAVSAPGGRFETSCFAEGPYGGHHSFDSYGTVVLFAGGVGITHPVPYIKHLVEGFSEGTVATRRILLVWTIQTPEHLEWIRPWMTEILGMDKRRDVLRIMLFVSQPRSTKEIHSPSSTVQMFPGRPNINTLLGMEQEHQVGAMAVTVCGPGALSDEVRLAVRNRQDRSHIDFIEEAFTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-03-27" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKC3</accession>
    <name>A0A1C3YKC3_GIBZE</name>
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            <fullName evidence="2">Chromosome 3, complete genome</fullName>
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        <name evidence="2" type="ORF">FGRAMPH1_01T21045</name>
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    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKC3"/>
    <dbReference type="STRING" id="229533.A0A1C3YKC3"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21045"/>
    <dbReference type="eggNOG" id="ENOG502S6JE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YKC3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF1">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="282" mass="32168" checksum="D918A827A4BB57BD" modified="2016-11-02" version="1">MMASPHRIVIEPMTQQLLVQNASEDWTGVTSTAERRKLQNRLNKRSQYLRKRQKLAKSRQGDLPKPSTEIAAQTSPNSMIQAIMEMCEVFNSPDISQRVFALASMAYLDYTMNAPRISQLPFLITLNVNIAIAKNATLLGFDRALMCIDEAISPFNQNGPWPPSYNPPKVLEPTPVQKAILHHPWLDIFPFAKFRDNIILAADAELLDDGELCEDVAEANLQNTERPSLIVWGDASLPHSWEASPLFLRKWGWLLHGCPEMLEATNRWRQSRGERLLHWYSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKD7</accession>
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    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 3, complete genome</fullName>
        </submittedName>
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    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB65004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKD7"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21241"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YKD7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF105">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methyltransf_25"/>
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    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SCB65004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="290" mass="32977" checksum="B9AD977661ADF581" modified="2016-11-02" version="1">MSSPEVPPRPRTPEELEDPAVRPEDGTIEPDTDSDSSYTKSIEVTDTESLKSSIIEYKWVHGRRFHAYGDGTYWGANDDRQQEAEDLMQVTISTSHIQHNILDVGCGTGIWAIDMADLHPSAEVVGVDLSPIQPNFVPLNCRFEVDDINKEYLKPGGWIEHVELWGNAMSDDGTMTEDSPLKTWVRIFDQIGEKIGNPFFWDPVEAFQEAGLQNISERKVKVPIGTWPKNKDLKQWGAWNRQFLMQGLEGFSIRGLTELLGWEYEKAQVFLVDMRKELLNPSLHSYVLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKR2</accession>
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            <fullName evidence="2">Chromosome 3, complete genome</fullName>
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        <name evidence="2" type="ORF">FGRAMPH1_01T20693</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKR2"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20693"/>
    <dbReference type="InParanoid" id="A0A1C3YKR2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="68" mass="7639" checksum="7D43BB0F483031D2" modified="2016-11-02" version="1">MCNEWDETKKKKPTGLASSRRVPSRDNESRCLKDIVEEKEKSTVETNELDILAKRPTNMTSVEVGTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YL51</accession>
    <name>A0A1C3YL51_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA-processing protein EFG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">rRNA-processing protein efg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FGRAMPH1_01T23641</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EFG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YL51"/>
    <dbReference type="STRING" id="229533.A0A1C3YL51"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23641"/>
    <dbReference type="eggNOG" id="KOG4484">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YL51"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019310">
        <property type="entry name" value="Efg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050786">
        <property type="entry name" value="EFG1_rRNA-proc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10153">
        <property type="entry name" value="Efg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="211"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SCB65158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="302" mass="34563" checksum="0E750B51F76C6D74" modified="2016-11-02" version="1">MAQKREYSEVGSPEPRDSGSFNGAKKRKQSKSKHRPNEGTSTWAKKRTRTIERLLNRNQELPANVRNDLERELGALKSTVSDKSFQRLRSAMISKYHMVRFFERKKASRLAKQLRKKIDETESTETDELEGLKRDLHIAEVDEAYTQHFPHAEPYISLYTSAKSEKEDEDKDDEDKLDYTPLKHRGLLHTERPPMWSEIEQAMKGGHHALRTIREKRPEITEGAKPERNQNKSKAATGKDKTVPASKAQPNPETNPTPYTKGKGKSGAAPKNRRERRLAERQGAQPVVKNDDDDSDDGGFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLM6</accession>
    <name>A0A1C3YLM6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T26967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YLM6"/>
    <dbReference type="STRING" id="229533.A0A1C3YLM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26967"/>
    <dbReference type="eggNOG" id="KOG3294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YLM6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB65426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="255" mass="28802" checksum="04EA85336E3A5FE2" modified="2016-11-02" version="1">MDNPHDYLITSRPPSRPVDPDNADSWVMLNQGGFVKLGNERILMKLESRISCDLSVPQELRARCASFQRKSDRGTLFLTNKRIVYLPLKPTQEPKFESFSAPILKFQDSTTSSSMWWGWVWKSDCIPVSGGGIPPDIPRLEVKFTFSDGGMMDFNEAYIRLRERLYQYQEMRREMGPGADVPDEPLPAYEAPSAQQASASTTADARPNRSESAASARAPDEPPPNYDEAQAQQLNIRLEDHVRGEIDRGAYENDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YM05</accession>
    <name>A0A1C3YM05_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FGRAMPH1_01T27517</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YM05"/>
    <dbReference type="STRING" id="229533.A0A1C3YM05"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27517"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YM05"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="BCS1 N-terminal" evidence="16">
        <location>
            <begin position="56"/>
            <end position="243"/>
        </location>
    </feature>
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        <location>
            <begin position="276"/>
            <end position="435"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="543"/>
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        <location>
            <begin position="543"/>
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        </location>
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        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
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            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="602"/>
            <end position="651"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="652"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SCB65484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="664" mass="74274" checksum="253C7F840FDB93A9" modified="2016-11-02" version="1">MDPLNSTSSGPGQDGLPKAPSQFAILDFIFPGFSTFSSIIHAYLGIDLNVYIPLLLIVSGIMFVWNYITEYSWSIIGQHLMSAVRIRTDDEIYNIVMAWVAKQRFSQGSRRFMVNTNINSRSWFLYCWNDDEDEDESESRKPLQYTPSVGSHFFWYKGHILLFERHENRDRSPFISSSSEELSISCFGRNPRIIKELLLDAQEQYIKKDEQQTVIYRGSLGSNGGDPTWQRCLSRASRPISTVILDEKTKSELIEDVTDYLNPNTRRWYSNRGIPYRRGYLLYGPPGTGKSSLSLALAGFFRMRIYMVSLSSILATEENLASLFAELPRRCVVLLEDIDSAGLTHTREEKKGDNSTEIDTVVPVPAAPAQPGAPPTTAPMPPGRLSLSGLLNILDGVASQEGRILIMTTNHLEKLDKALIRPGRVDKIVQFGLADDEMSASIFRAIYAPYEGEDVDVGAAKVKYLDIEEAQKHAALAEKTRLGTLERISALATKFAAKIPSLEFSPAEIQGLLLKNKRNPEAAIDAIDDWVVETRKERKQKEIEAAEKRRKEEADAIKAEAKKKRKEERKKAKKAKAKAKRKSNGESSGSDSDSDSDSDSEAETKSDNKKEDTDKKDDKPADKPKETEAEVDEKKDSKVEEESTGESKPKGTSDSGYDTPNPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMN9</accession>
    <name>A0A1C3YMN9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T12447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YMN9"/>
    <dbReference type="STRING" id="229533.A0A1C3YMN9"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12447"/>
    <dbReference type="eggNOG" id="ENOG502QSAC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YMN9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039634">
        <property type="entry name" value="Bul1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904:SF1">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB65780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="475" mass="52233" checksum="07C65A17243D3774" modified="2016-11-02" version="1">MSAVQVLFNATPNISIAPESKRRGSWVPIRRKSECPLDVSIDRHFEAKIYTSGSTITGSVSLSPQTSITVDAFEIVFTGTSSTIVQMLHQGSTPKSSHKFLLLKMPIPESALPENGVLEAGFTYQVPFSFVIPYQLPSAACKHRDPTIRERHLHLPPTIGSWEHDDMAVHTININYAVEARGSFQTGKGKSMTLERTHPVKVMPFVPEQPPLHIVPGNPRYILSQEKTIRKDILSSKLGFIRASTGQPDSVIITSDKLQPADCSLNIDLEFWPNGKKEPPEIYAKSAAIKASTYYSTGHMSFLPDQHNFPSVMPNPILSFVLDEDATVSSSSKPAWVQTSSSPTPSPSVSRRGSENPDIGTEPSRITSRRGSKTSDIMRSEAPRYTATLPISITLPSPDNKILLPTFHSCLISRTYVLEVVLASRAHGSSFTLRLPLQIAVEGQGETGVNHVPTYEQVQANQDLFDTLPTYNIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YND8</accession>
    <name>A0A1C3YND8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FGRAMPH1_01T15323</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YND8"/>
    <dbReference type="STRING" id="229533.A0A1C3YND8"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15323"/>
    <dbReference type="eggNOG" id="ENOG502SSWS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YND8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="5">
        <location>
            <begin position="156"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="560"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="670"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="762"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="182"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="486"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="685"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="709"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SCB65963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="894" mass="98572" checksum="285EC25EE47EFCB6" modified="2016-11-02" version="1">MERPVSRSSHGTRTASRSSTSTNNTKVSMHTAHTSNSHPPGSPAPSHAHRFYHATCQRPSSTTPRTTDRTSRLTRESSSESTRQPAMSSFLQEKLRESRQAESDKSSTWSRSHTDANSSGEFSRSLRSPARVGDSEHRSYSPFTEQSKKKGMGVMDMEQVISSLHKKNFDLKLELYHRRERQTALEDKVEALEMEKSRAEETNQHLSQEMEKRDKAIEEAVAMIVALEARVEEFAKERSIIEQIQSEGQYSAHNFNPCYEDPRPASQTPISAKRTKDDRIINRMPSFMSDHNENTENLRNVYLGARGSVISLAQVPEGPGEGDTGRSPSLSILSESSFVSVYGSKEDEDSSLQEDEPVTFDGSASLPARASAINRPKTAFVQSHSSPNRSARSSSVSNHPAHFDSIQNVVEYSSPRRSERHHQPSRMASRPQSRDQDRSERFAGRASMSPNHQRLKQEKRDSLRRVTTEAPGGVRLHDQNLPPTPDTVSTSTLRRFNNSNEALLRPPTARPSHSALSEASENDGSLGTYSGVRLEQTPMRAVKASAQIIELNNRVYRENQGKSIQRPRSVDETTISNRRGNDWDSDIDDDSDVESLESSIDIWMRQSSKQIKKNGRTSPDLFSFPTSAAARDGWAMDAMFGAGNGHQGGASTGLDPDRIRDLFPVQQELFSASMPPPPPDRSSSLNPQAGQQSKTSFLSRPLANAKASKGVRKKGHQRRASDDIQIRAGAHIQAQGPSAGDKNHYPPIANQQSTQNKFTKFFRRSSTGPPSGAPTPTPRTEHGPTEPPNGAFSSSTGAPVLPPWISRTGAAEEDRDSATPPPIMRKSRQGRNVSVDFDMADDPVMSQESGTPGTPKPPANEKDTAEQTESPRGAGATGSRRKWLPAFSLRNKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1R999</accession>
    <name>I1R999_GIBZE</name>
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        <submittedName>
            <fullName evidence="12">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG00028.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T00105</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Secreted metalloproteinase that allows assimilation of proteinaceous substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M43B family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF71852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315613.1">
        <property type="nucleotide sequence ID" value="XM_011317311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1R999"/>
    <dbReference type="SMR" id="I1R999"/>
    <dbReference type="STRING" id="229533.I1R999"/>
    <dbReference type="EnsemblFungi" id="CEF71852">
        <property type="protein sequence ID" value="CEF71852"/>
        <property type="gene ID" value="FGRRES_00028"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00028"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00105"/>
    <dbReference type="eggNOG" id="ENOG502RYKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048726_0_0_1"/>
    <dbReference type="InParanoid" id="I1R999"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04275">
        <property type="entry name" value="ZnMc_pappalysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466:SF1">
        <property type="entry name" value="METALLOPROTEASE MEP1 (AFU_ORTHOLOGUE AFUA_1G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124002" evidence="10">
        <location>
            <begin position="17"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M43 pregnancy-associated plasma-A" evidence="11">
        <location>
            <begin position="127"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF71852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF71852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="275" mass="29684" checksum="38D06561C1E27593" modified="2012-06-13" version="1">MVSKLALALFFGNALAGLAGRALPPRCAVADPTAEQVQHAQNLKKIESVSKVAAASITVDTYFHVVSSSSSKYISKAKLTAQLKALNDAYGPNDITFKLIDTTFTTNTNWAAGNGELAMKRQLRQGDYKTLNLYFTDVAKLGGTEALGYCYFPEPNVSTGSQKFILDGCVIVAETVPGGTAAPYNLGGTAVHEVGHWFNLFHTFQDGCNGGDLVADTPAQARQTSGCPARMDTCPNQAGDDPIHNYMDYSDDVCYEEFTPGQQTRMHSAWTAYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1R9E6</accession>
    <accession>A0A098CZ95</accession>
    <name>I1R9E6_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG00082.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T00247</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF71923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315678.1">
        <property type="nucleotide sequence ID" value="XM_011317376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1R9E6"/>
    <dbReference type="STRING" id="229533.I1R9E6"/>
    <dbReference type="ESTHER" id="gibze-i1r9e6">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF71923">
        <property type="protein sequence ID" value="CEF71923"/>
        <property type="gene ID" value="FGRRES_00082"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00082"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00247"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_17_1_1"/>
    <dbReference type="InParanoid" id="I1R9E6"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="10"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF71923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF71923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="534" mass="59804" checksum="AD0E5495549E43BF" modified="2012-06-13" version="1">MSYQRRDYSLVTGPLGHIKGLTISTNDTPAVHYFGGLPYALPPTGQWRFRSPRKLPAGYTYDTASHPGQFTKGTWVCPQPDSSIPPDPADVGEDCLQLNIWIPARPAPKEGWPVCFYIHGGFLQVGNANTQPEALVPLLSETAFGAIMVQPSYRLNALGFLAGKELAAEASAHGDTTGNMGMWDQRAALEWTFENIKNFGGNPANITVAGYSAGAYSTFQQLAHELFCESDKPAIIRRIAMFSNGPGTEPKALHEVQPQFEEFITRLGIPLDDKDDVKLAKLRALPYEKLIEVQSEMKISEFRVLVDGHFYPSSLIDKVNNGEFAKQMKSRGIKLLNGECQEEHTMYRRWRTPTESYASVHQRLSSDFSPKVTETLMSHYCGAGKELPAGNKTWREFFGRLYANVQVHLLERGFHNALVQGGLEGGKDILRYRIERRLECVEEKIPSHLGVTHLTDIPIWLWGTGYEAGLTEEEKGMLKGWNEGFAQFVNGDDVNWGPVDVNQMKRWRSDGETDVVKDDLWEDGVAFWQLINSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>I1R9F4</accession>
    <accession>A0A098D1W4</accession>
    <name>I1R9F4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG00092.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T00273</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF71936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315691.1">
        <property type="nucleotide sequence ID" value="XM_011317389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1R9F4"/>
    <dbReference type="SMR" id="I1R9F4"/>
    <dbReference type="STRING" id="229533.I1R9F4"/>
    <dbReference type="EnsemblFungi" id="CEF71936">
        <property type="protein sequence ID" value="CEF71936"/>
        <property type="gene ID" value="FGRRES_00092"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00092"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00273"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_6_3_1"/>
    <dbReference type="InParanoid" id="I1R9F4"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="9"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="298"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF71936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF71936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="442" mass="48812" checksum="CD9F93D17F913408" modified="2012-06-13" version="1">MAVTSEKEFHVAIVGAGIGGLALAMALHKKGISFTLYEDAKEFSAVGAGIGFAPNGMRTMDLIEPGFRPLYEKICVGNKGDDAQTIFFEGMLLEEGFGRDQPWVGKSGWGHPDYIRKSAHRKELLDIMTSFVPKDSVKFSKRLTKIKQSPDGVTLSFQDGTTANCDILAGADGIKSTVRGHVLEKHPNQIAPVYAGAYCYRAVIPMDEAYEILGDLTDVAKFYFGHKKSAISYRITQGNEFNYLLCVADGLNAWKIPHAVTELIPHEQMMADFEGPGIDPKFRELLAKAKPVKWGFFHHRHTAAYFRDRVALVGDSAHASLPFQAAGAAQGLEDALVLSALVAELAKQHQRGASQQPAIQAALTAYDSVRRPRAQKQLEQAAEVGDMMFFQHKEAGDDMLKILPHLQQGRFNWLWFHDMNDDAKEAVSRMHKLIGSNPPSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1R9H6</accession>
    <accession>A0A098CZA0</accession>
    <name>I1R9H6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG00117.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T00329</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF71964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315719.1">
        <property type="nucleotide sequence ID" value="XM_011317417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1R9H6"/>
    <dbReference type="STRING" id="229533.I1R9H6"/>
    <dbReference type="EnsemblFungi" id="CEF71964">
        <property type="protein sequence ID" value="CEF71964"/>
        <property type="gene ID" value="FGRRES_00117"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00117"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00329"/>
    <dbReference type="eggNOG" id="ENOG502SQMB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060131_3_1_1"/>
    <dbReference type="InParanoid" id="I1R9H6"/>
    <dbReference type="OrthoDB" id="2115692at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="101"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF71964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF71964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="236" mass="27318" checksum="6D5FF9F1F6E909E0" modified="2012-06-13" version="1">MSQITLRDANYSDLPEVARVMSKAFWNDNLFGDLIHPHREKYPDDPDLYWLRRARVSFWDYRWRGIVAIAKDDSGKDVIAGIAQWERLGKEERNSNVHISIPIRNLFKPLSSLVMNIHARIWPNRAADPENEDIIERTYPYFERIWSGKRAESWYLSALAVHPDFQRQGVGKRLAQWGIEKAQAEGVCASLVAAHGTDDFYIKLGFDEQFGRAGDGESNPLADVEGSNMYWYWPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1R9U8</accession>
    <name>I1R9U8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG00260.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T00699</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315901.1">
        <property type="nucleotide sequence ID" value="XM_011317599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1R9U8"/>
    <dbReference type="STRING" id="229533.I1R9U8"/>
    <dbReference type="EnsemblFungi" id="CEF72151">
        <property type="protein sequence ID" value="CEF72151"/>
        <property type="gene ID" value="FGRRES_00260"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00260"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00699"/>
    <dbReference type="eggNOG" id="ENOG502RM3Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186261_0_0_1"/>
    <dbReference type="InParanoid" id="I1R9U8"/>
    <dbReference type="OrthoDB" id="4611802at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124041" evidence="1">
        <location>
            <begin position="18"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF72151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="77" mass="7980" checksum="72702C44A7662E61" modified="2012-06-13" version="1">MKFTAVAITALASVAAASPSGCKPGTYSCTPDKSGWQVCDVTSQWVAAGVCPPKTGCVFYKKSASPYCVPPGFKFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>I1RD10</accession>
    <name>I1RD10_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 1, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="7" type="primary">FG01497.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T03669</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317306.1">
        <property type="nucleotide sequence ID" value="XM_011319004.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I1RD10">
        <property type="interactions" value="350"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RD10"/>
    <dbReference type="EnsemblFungi" id="CEF73640">
        <property type="protein sequence ID" value="CEF73640"/>
        <property type="gene ID" value="FGRRES_01497"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01497"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03669"/>
    <dbReference type="eggNOG" id="KOG2128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000972_1_1_1"/>
    <dbReference type="InParanoid" id="I1RD10"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:GTPase activator activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd05127">
        <property type="entry name" value="RasGAP_IQGAP_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Calponin-like domain"/>
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        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
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        <property type="entry name" value="aa-tRNA-synth_II"/>
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        <property type="entry name" value="CH_dom"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="313"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="5">
        <location>
            <begin position="640"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="1123"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="887"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF73640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1757" mass="202315" checksum="0906E58C6F94EB51" modified="2012-06-13" version="1">MSSRTHYFQSQHQTQSQSPSQPLPHQHLRPFRQSHTIDFASNSNVSPALVNRFPSTTSSSASSGYSHGSDHSFNSQYTSASSSAGYGATVHGHKRAQSDVRARAKTFETGENMTSKKAPDNIYNSARHSLRPLPQAPAGTRPDTPPNARHDRTKSVDIGKLSISHMGQISPTKGSPTKTSPLKTSSPSRPLPMRPNSMLLTRSDSFLPQENTLSPLSPHHVHSTHIARDELEGLGKSSTSQLRTLSRLVSSDSPEDFTITSPTQEVVGLRGRRRLQRGDRSNTGPSQKNTGYSWEGRNWMDKQRQFLQAYEYLCHIGEAKEWIEDVIHKNIPPIVQLEEALRDGVTLAEVVESLNPDRRYRIFQHPKLQYRHSDNIAIFFRYLDEVELPDLFRFELIDLYEKKNIPKVIYCIHALSWLLFRKGIVDFRIGNLVGQLEFEHHELEAMQKGLDKLGVTMPSFGNMSADFGVPEPEPEPEETEDERIARELKENEESIVDMQAQIRGALLRVKLGDTMQQLWDSEEWLIDLQSRIRGDFTRQIMDYRLQMKRFAIQLQSSARGFLVRRRFNRREQILEALEPDILELQTMIRANKVRNQVRDTSAQLAKCRGPIREIQAISRGFLARKSHVAQYEETKESSGMVEKLQAAVRGALLRGKVGQDLEDLEMQTPAIVDLQAAARALLTRNQVDRELHHLKSSGPKWEKLQAFARGFRAREDDKALRSELKKHIPDIEQLQALARGLAVRQNDQALRAELNEHAPAVERLQAFARGLRARQEDKALRSELDKHTTNVEQLQSFVRAAAVRRDVADTLDALKENEPAVIDLQALIRAMLERQRVAVILEQLEEQVPEVTTLQSHIRGFLYRKQHEAFLEELDSHTPQIVDLQSILRAMMERARVEDIMAELEQEEESIIAFQAAANGFMVRARFEEKKRFYNENMQKVIKIQSFVRAKVQGEAYKSLTTGKNPPVNAVKNFVHLLNDSDFDFNEEIEFERIRKTVVQQVRQNEMLENYIDQLDIKIALLVKNKITLDEVVRHQHNYGGNSMHFIANSSMSSANQFDLKALNKSSRKKLESYQQLFFNLQTQPQYLARLFKRIREQGTAEKECKRIELLMMGLFGYAQKRREEYYLLKLISRSVREEISCARDVQDFIRGNFFWSKLLNNYTRSPRDRKYLRDLLGPLIRDNIVEDPALDLESDPMQIYRSAINNTELATGRPDQRPLDVPREVAIRDPETRQLFIDHLRDLRDICDQFFLALEDFLHKMPYGLRFVCNQIFENLRQQFKREPPENLLQVVANWLWRFYLQPAVIAPENVGVIEKSLSPLQKRNLSEVAKVISQIATGRPFGGDNVYLQPLNAFVAESVERLLQITSDVIAVPDAERTFDIDEFNDLYAKNKPTLYIKMTDVFSIHNLVAAELQTMCPSRDDILREIMHELGSAKSNENEMNAAGSSDIHMFLTPKLHETDDPEADVKALFMETKRCVLYIIRVQTGTNLLEILVKPISPEDDHKWRMLLHDEFSVGSNTRGAYSDSNMIDVTRMSYQELKRTALENIMRLEKLGRITKHNYYQDVLNAIALDIRTKSRRRVQRQRELEGVRLTLNNLHEKAKYLEQQRKSYDDYIESAMATLQNKKGRKRFLLPFTKQYNHQRELERSGRVPKFGSYKYSARALSEKGVLVSWSGITDFEKINLTLSCDEVGVFSLEGSRGHIQIPGASALMPIEDLLQAQFEAHQFMTLFEGSLKLNVNLLLHLLYKKFYRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RD53</accession>
    <name>I1RD53_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG01542.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T03759</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317352.1">
        <property type="nucleotide sequence ID" value="XM_011319050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RD53"/>
    <dbReference type="FunCoup" id="I1RD53">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RD53"/>
    <dbReference type="EnsemblFungi" id="CEF73686">
        <property type="protein sequence ID" value="CEF73686"/>
        <property type="gene ID" value="FGRRES_01542"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01542"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03759"/>
    <dbReference type="eggNOG" id="ENOG502RZQV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092488_1_1_1"/>
    <dbReference type="InParanoid" id="I1RD53"/>
    <dbReference type="OrthoDB" id="2100652at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042432">
        <property type="entry name" value="Coa1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF73686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="217" mass="24591" checksum="919FA45B6F14B77E" modified="2012-06-13" version="1">MSQQLALPRLVQRRLAAVLKTRTVTLRPAQRRWLTPAPKPGDGPMMSRRADRELPDISDVTFRWRRTFPIFLLIVAASSVAIFNYQKMSSPVVSSTLYALRTNSEARALLGDEIYFRHQIPWIHGEMNQLHGRIDIWFSVRGTKGEGVMRFASNRPTSKGFFSTTEWSLTMEDGTRLDLLDSGDPFRALVGGGGDDLPPPVEEDAPTRGFRKQVEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1RDY1</accession>
    <name>I1RDY1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG01850.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T04479</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317696.1">
        <property type="nucleotide sequence ID" value="XM_011319394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RDY1"/>
    <dbReference type="STRING" id="229533.I1RDY1"/>
    <dbReference type="EnsemblFungi" id="CEF74046">
        <property type="protein sequence ID" value="CEF74046"/>
        <property type="gene ID" value="FGRRES_01850"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01850"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04479"/>
    <dbReference type="eggNOG" id="ENOG502QS87">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023635_0_0_1"/>
    <dbReference type="InParanoid" id="I1RDY1"/>
    <dbReference type="OrthoDB" id="4898142at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF74046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="653" mass="72929" checksum="DA4AEF1C922DD4D2" modified="2012-06-13" version="1">MSKNVCYVEDAAEDSETSVLQGIQATRRYAVSEAPGPASPPPKERPNTGKSRGEHRRHSSRRQVTPPSDDYSDEEPPRPAPRREERPRRDHEREREREQQREQRDKDRRRKERKQKEAAELQQRKVRSEAKQQAQAQAQAQAQAQQAPPREREAKPARRPRPTSLSHTRTEPVIQQYRRGRVEDPSCYGVQQPAVSGMRPRAQTRPHSYYPGQPAPPISNAGWHHHQHSQPPPSFPVGSFPGPSPYFPGASSPSVSGIPPSPSPVGGGPPGFFDMPSSQASAHLRNRFERPASSMGFRQDQPSPSNIGYPHDEYEIEEQQPEPPRPLRRASRSSKKPQQIEDDRRRMPPPESIPRPKSAMPTQTTPFRAPPQTMTRQKRTPSRPPPSTRSRVGFADQQGYDDDEFADSPGLFADSPEANFDRRTALSRPRRSSVAYESYGADIVPARSTRRGSVAYERGGIDIIPARNTRRDSFYDYEQYDSGGASLEDEDKYMDAMKYQEDINGGPAMPLTADALRKASNPRLGGGSSRSSGSHDDSEYKRSNTTGLTRSSSSDTDNVTIKVSGSAVVRVSGAEIECGDGGEITFSRPTAGSRLGSDRASSYYQLEDVQSRVERKALPYRPHTPSRSDSHHRGYSGNHAPYDPSLTMDDYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>I1RFV5</accession>
    <name>I1RFV5_GIBZE</name>
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        <recommendedName>
            <fullName evidence="8">Maintenance of mitochondrial morphology protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG02596.1</name>
        <name evidence="8" type="synonym">MMM1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T06231</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MMM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318539.1">
        <property type="nucleotide sequence ID" value="XM_011320237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RFV5"/>
    <dbReference type="SMR" id="I1RFV5"/>
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        <property type="interactions" value="79"/>
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        <property type="gene ID" value="FGRRES_02596"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06231"/>
    <dbReference type="eggNOG" id="ENOG502QUUW">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_032730_1_0_1"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="entry name" value="SMP_Mmm1"/>
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        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
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    <keyword evidence="3 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
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    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
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    <feature type="topological domain" description="Cytoplasmic" evidence="8">
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            <begin position="41"/>
            <end position="408"/>
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    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="113"/>
            <end position="329"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="356"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF74920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="408" mass="45276" checksum="281B971EDFCBE864" modified="2012-06-13" version="1">MAGDTCPQPTEPTLSFTQGLIVGQLSVVLVLAAFIKFFIFGDPPSPDVTASLRATERRSRTLAHKRSLLSLRSPGNRQDRELNRKKSTVLRNPPALTIGSILSKTYYNVDSHQPESLDWFNVLIGQTIAQFRSDAQHDDAILDSLSKALNGGSRPDFIDEIRVTELSLGEDFPILSNCRIIPVDEDGVSLGHGKKFDPDKAARDGTRLQARMDVDLSDMLTLAVETKLLLNYPKKLSAVLPVALAVSVVRFSGTLSISFIPSNPSQSTPTRMIFNFLDDYRLDFSIRSLLGSRSRLQDVPKIAQLIESRLHRWFDERAVEPRFQEIALPSLWPRKKNTRGPDDGLAEGSVPIGRSKGRDASRDPQEEARGDAEIRDRGTIRQRRGTRGSDSDDFSMPGSLPSFQIPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>I1RFV7</accession>
    <name>I1RFV7_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GDP-mannose transporter</fullName>
            <shortName evidence="7">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FGRAMPH1_01T06239</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasmic vesicle membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318543.1">
        <property type="nucleotide sequence ID" value="XM_011320241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RFV7"/>
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        <property type="interactions" value="559"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RFV7"/>
    <dbReference type="EnsemblFungi" id="CEF74924">
        <property type="protein sequence ID" value="CEF74924"/>
        <property type="gene ID" value="FGRRES_02598"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02598"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06239"/>
    <dbReference type="eggNOG" id="KOG1444">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025360_1_2_1"/>
    <dbReference type="InParanoid" id="I1RFV7"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    </feature>
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            <end position="307"/>
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        <location>
            <begin position="1"/>
            <end position="33"/>
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    </feature>
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        <location>
            <begin position="367"/>
            <end position="390"/>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF74924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="390" mass="42679" checksum="5CFFAA7B28F3EC14" modified="2012-06-13" version="1">MTDKKNEDYVVRMGDDNYDKNEKPSFQPRSPPPMAYGSSQLHSLEQLEKSPPLSIAAYCLSSISMTVVNKYVVSGSFWNLNFFYLTVQAVVCIGTITLCKQLGMIKVLAPFDADRARKWFPISLLLVGMIYTSTKSLQFLSVPVYTIFKNLTIIVIAYGEVLWFGGSVTPLALLSFGLMVLSSIVAAWADIQSAINGDFGTGDSAAAVSTLNAGYAWMGMNVFCSAAYVLGMRKVIKKMNFKDWDTMYYNNLLTIPVLVICSLLTEDWSAYNFSRNFPDDTRNKIIIGMIYSGLAAIFISYCSAWCIRVTSSTTYSMVGALNKLPIAISGLIFFSAPVTFGSVSAIFIGFISGLVYAWSRVRQSMSSGGSLPTVAPPMSASAKSNRDANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1RHU4</accession>
    <name>I1RHU4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG03359.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T12689</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322372.1">
        <property type="nucleotide sequence ID" value="XM_011324070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RHU4"/>
    <dbReference type="EnsemblFungi" id="CEF78147">
        <property type="protein sequence ID" value="CEF78147"/>
        <property type="gene ID" value="FGRRES_03359"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03359"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12689"/>
    <dbReference type="eggNOG" id="ENOG502SQUS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_683421_0_0_1"/>
    <dbReference type="InParanoid" id="I1RHU4"/>
    <dbReference type="OrthoDB" id="3836772at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39602">
        <property type="entry name" value="ACW-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39602:SF2">
        <property type="entry name" value="ACW-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF78147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="385" mass="39165" checksum="F49AE716DB09F842" modified="2012-06-13" version="1">MKPSVILSTSVFAGTTVARLYKRDELVARADSSSSLSTASVVANPTDTGTDGGEETLSTDTGAPATVSTTASSASMSPTIPSTYDCLSDCNSNYDKCRTTPGANMSTCAAQYAGCLGYNPFQGGSLVTPTACSAPASDTPKPTQSAPGANMSTCAAQYAGCLGYNPFEGGSLVTPTACSVTASETSKPTQSGTSDCLNDCNNKYDKCRTAPGANMATCASEYAGCLGYNPFEGGSLVAPTACSDKAEPTQSGTDECVKECNSDYDKCRTAPDANMSTCAAQYSQCLGYNPFDGSESLATPTACSSGAGTTATDTGVVQSSMASQSPSPLPDTTMQMTGTYENPVATCTSDMCAEPTMTESPVVVDGAESLRPWMPLVALVALAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RHY9</accession>
    <accession>A0A098DID5</accession>
    <name>I1RHY9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG03408.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T12815</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322314.1">
        <property type="nucleotide sequence ID" value="XM_011324012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RHY9"/>
    <dbReference type="EnsemblFungi" id="CEF78210">
        <property type="protein sequence ID" value="CEF78210"/>
        <property type="gene ID" value="FGRRES_03408"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03408"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12815"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="InParanoid" id="I1RHY9"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF78210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="270" mass="29562" checksum="2190BA789474B293" modified="2012-06-13" version="1">MANPYPFQDKVIVVSGASRGTGLSLSRYLLTRGAKVSMAATSKKNLEKAIAGLEQDIPDVKDRVIYFPTDVTKPEDVKFWIEGTVAKWGELDGAANVAAKMNKSIHPIEDLDLEELKEMLDVNVIGTFNCIKYEMKNMKPGGSIVNCGSQQVKYASGNMGAYAASKNAIRGLSQSAAYEGGAKYPKNPIRVNLLCPGCIDTDMIKQPLHLPNGTTWTMTEDDNLTSIIKRYSKPQEVAASIAFLLGDESKFMTKQEIYVDGGWMESNYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>I1RHZ5</accession>
    <name>I1RHZ5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG03414.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T12827</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322308.1">
        <property type="nucleotide sequence ID" value="XM_011324006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RHZ5"/>
    <dbReference type="STRING" id="229533.I1RHZ5"/>
    <dbReference type="EnsemblFungi" id="CEF78216">
        <property type="protein sequence ID" value="CEF78216"/>
        <property type="gene ID" value="FGRRES_03414"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03414"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12827"/>
    <dbReference type="eggNOG" id="KOG2844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_11_2_1"/>
    <dbReference type="InParanoid" id="I1RHZ5"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032503">
        <property type="entry name" value="FAO_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16350">
        <property type="entry name" value="FAO_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase central" evidence="5">
        <location>
            <begin position="372"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="GCVT N-terminal" evidence="3">
        <location>
            <begin position="429"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="4">
        <location>
            <begin position="737"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF78216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="833" mass="91412" checksum="B3BC47398D45B20C" modified="2012-06-13" version="1">MAPSPRVLIIGAGIVGVNVADELVQRGWTDITVLEQGPLAMPGGSTSHAPGLVFQTNTSKTLTKMATYTVEKLMSLGSFNQVGGLEIATTPARLEELKRKRGYAYSWGVEANLISPEKCLEIYPLLDKSKVLGGLHIPTDGLALARDAQAKLIARTQAAGVKYHESTLVTSIDHHDGHVSSVNTKNGKFEADIVISCAGLWGVEVGAMVGLPIPLTPMAHQYAHTTSVPSQKGKNEEPNGARLPILRHQDQDLYYREHGDHYGIGYYGHRPMPVVAASLGETPKDIDYKNMPSSLKFTPKDFEPGWKLSQEILPALRETKIDHGFNGIMSFTPDGGPLVGQAPNFDNFYVAEAVWVTQSAGVGRAMAELLTTGRAEIDLSECELSRFEQVQLSPAYVVETGSQQFVEVYDILHPLQPKESPRNLRVSPFHQRQQQLGAFFLEAGGWERPHYFEANEKLLKDLPEAWKPVERDAWSSQFYSPITAVEAWKTRTGVALYDQTPIRRLEIAGPGAAELLQRLTTGNVAGEVGKVTFTLLLDNHGGIRSDIFVARLGEDLFHLGVNGPVDLHYFTREAKVQTKASPHRAVHVRDITGGLASVGVWGPLAKDLMKLVSKDNFTDRAFPYLTTKKIEVSGIPAIATHFSYIGEEGFEIYTTADNGLRLWDALWQGGLPYGVIAAGRSAFNALRIEKGFRSWGSDMTQEYDPYEAGLEFALHPGKDGYVGYNALKGRSSEKVSRRIRGLTVDDGKSVVLGKEPVFVKGRAVGYVTSAAFGYSIRKPIAYAYLPKEVIEGDKVEIEYFGKRIKATVTSLPFYQPEKSAYGQTAQASFSARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJB0</accession>
    <accession>A0A098DK38</accession>
    <name>I1RJB0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG03919.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T14035</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321749.1">
        <property type="nucleotide sequence ID" value="XM_011323447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJB0"/>
    <dbReference type="STRING" id="229533.I1RJB0"/>
    <dbReference type="EnsemblFungi" id="CEF78820">
        <property type="protein sequence ID" value="CEF78820"/>
        <property type="gene ID" value="FGRRES_03919"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03919"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14035"/>
    <dbReference type="eggNOG" id="ENOG502QR47">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004835_2_1_1"/>
    <dbReference type="InParanoid" id="I1RJB0"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="PHI-base" id="PHI:1880"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF78820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="615" mass="68819" checksum="D6ACAB779284F6DB" modified="2012-06-13" version="1">MTPQASADRLRDQEPERRPGKRPAPRGTAFYPRKRANTACQVCRSRKTKCDNLKPACSYCLSVGANCIQSPVDLSAFDPASLKILERLDELERLLRDTRDNDSHSEPAVSVVQANSHVQELPPVAESSVEELDPSPMSDIPLRSILPEKMESLLLWSVLSRDMSAHATLQNDAPQPSPSYSPGCNSLADIADLDTQGVKALLDNFFAHVHCKNPILEEAAARRVVLNVVIEGIDWSPGSCLTLIICALGKIATSLDATFHLRPDSTQYLEAQALFQAAQKRIGTLMARSDIISAQCFFLSGVFLMSTFRPFEAWRYFSQALATCQTLPFLQKAQFLSASDGPEFPRPELGETQQEAVYWSAWKSERELRGELSLPDFSMPYASSVLYPPFFPTPPHPLESTKTTASSRQHTAWLFYLSEISLRRLSNRTCNDILELHRASPSNVEFLKQLALIIPAYEAQANEWSESLPPELSIASNPNEDNVCCFVLRGHLVNFLERLYWPFVMAHLAALEGEMSTPVPGLQYVNKGLEYHVLNVDVNQAGFLHRHHGTWFMIRALVRSATVLLAARLLGSVMPNGWREACERIMQVLRAWEDDVAGLSHHRIFLEEVLHKLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJF8</accession>
    <accession>A0A098DIX3</accession>
    <name>I1RJF8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG03975.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T14163</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321685.1">
        <property type="nucleotide sequence ID" value="XM_011323383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJF8"/>
    <dbReference type="EnsemblFungi" id="CEF78884">
        <property type="protein sequence ID" value="CEF78884"/>
        <property type="gene ID" value="FGRRES_03975"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03975"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14163"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_9_4_1"/>
    <dbReference type="InParanoid" id="I1RJF8"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010968449" evidence="8">
        <location>
            <begin position="18"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="70"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="405"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="671"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="411"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="470"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="547"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF78884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="811" mass="84248" checksum="C2C5A4A02E10DA79" modified="2012-06-13" version="1">MLSTLFLAVAAPALATAFNAPNVPVGTDDSSPDGLIRFPLKVSTGAPVVKGVTKRQNEVALESQQNGFFYSIDVTLGTPGQKVTVNLDTGSAELWVNPVCEKAQQPAFCKQFGHFGESSTFVDLNTTGGVVYGTGYAYWNYGYDNVVVGSAAIRNQVFGVAYDSSFTGVGIMGAGPDLNGWDAPYPLVIDSMVKQGLIKSRALSLDIRTINSDRGAVIFGGIDTAKYTGRLQKLPIIPAASSPDGLTRYWVSLDGISLVQEDGTVDSAFSGSTPQPVLLDSGYTVSALPGSIFNKIVAAFPTAKSNGGAYVDVDCSVADIKGSVDFKFGDKTIKVPYADFIWHNDDRCVLGVFQDDEFPVLGDTFLRAAYVVYDWDNRNVWIANNEDCGTNLVAIGTGPDAVPDLVGQCGSDSETTTSASETASATETETETETASATESEAVTATTEDVTSAETDTTTGYFPTTRYSNSTASVTGKGTSTTKKATGGSGESYELPSYTDSSASTTITSTVVTSKVYTVTACPPSVTNCPVGQVTTETITSLTTYCPGSDDSSSHSTTVEGEGATHPTGAVHLTSYVTATNMHTITSCPGEGACHTSVITEIVHNTQIASPEEPTGIFTIPEAIQCGAGNFGCKEATTKGYRTVTITPVVKAPKPTPVPGYCATCGPLKGHGHHNDDDKETATGGYTAPGKQTGGYDQPTQAHPGQDYPRPTGGDSPKPTGDSHNPTGDSDKPSGDAPKPNPLEELHTYRPTNVFPQIPSSVATVVKPTGTPQAGGPSEPAGTPPVVINGASGWNVPVVAAVVVGAFVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RK41</accession>
    <name>I1RK41_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG04229.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T14793</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321394.1">
        <property type="nucleotide sequence ID" value="XM_011323092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RK41"/>
    <dbReference type="FunCoup" id="I1RK41">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RK41"/>
    <dbReference type="EnsemblFungi" id="CEF79198">
        <property type="protein sequence ID" value="CEF79198"/>
        <property type="gene ID" value="FGRRES_04229"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04229"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14793"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_4_1"/>
    <dbReference type="InParanoid" id="I1RK41"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF35">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF79198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="338" mass="37068" checksum="F76D4FDC4512BBA6" modified="2012-06-13" version="1">MSAQLKHKAVWEASPLAFLSRQFIEGVPNIPKNVNLSGQTALITGSNVGLGFESARQLLALDLSHLIIAVRNQARGDAAAKKLRNEFPNAKIQVSLVDMASYKSIQSLVEWCETLSRLDIAILNAGLSRPQFERSEASKHEMTHQINYLSTALLTILLIPVLKTKRGTSGPAHLSIVGSDMSYWAQWTGTNDSIWDVIDDPAHFSSNGAYQISKLLLIMFVDKISQHVSPQEVIVNYPNPGACRGTEFGNDGNSGLVEKIWMAFAKPIIGRTVATGARSYVDAVAVKGIESHGSFIGEGKIKPFPVMMYEPAGKMLQETAWKDLMEELSFAKPMEILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1RKX1</accession>
    <accession>A0A098DM96</accession>
    <name>I1RKX1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG04542.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T15547</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321045.1">
        <property type="nucleotide sequence ID" value="XM_011322743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RKX1"/>
    <dbReference type="STRING" id="229533.I1RKX1"/>
    <dbReference type="EnsemblFungi" id="CEF79575">
        <property type="protein sequence ID" value="CEF79575"/>
        <property type="gene ID" value="FGRRES_04542"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04542"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15547"/>
    <dbReference type="eggNOG" id="ENOG502QQXH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_4_3_1"/>
    <dbReference type="InParanoid" id="I1RKX1"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF12">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11840)-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="31"/>
            <end position="159"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF79575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="543" mass="59994" checksum="FA5E735E2C38758B" modified="2012-06-13" version="1">MAPHAEQDESTPGITRLPPPARPAFSASPPRLLIIGAGNRGKAYAEAIKNASNGVIVGVVEPIALKRRHLGRKYIWGTREPTPGEEFSDWPEFVEWELSRRQKAASGATDVPEGVDAVFVCVQDGMHKDVVLGLAPLKLHIMCEKPLAPNLEDCMAIYNSLSPDSSGCSEKLFAIGHVLRYSPHNIMMRKLLLEDKVIGDIMAVNHTEPVGWYHFTHSYVRGNWRNEKAAAPSLLAKSCHDMDILYWILAASPPGSNKPTHVPKDISSSGSLQYFRKERKPVEAGNATNCLSCAYEPSCQFSAKRIYTGADLKSQQQEHFCTVVAPEIEDCVPNSDPEIAKKAILSKLAEDYSEDTPAEDVSKRNTFGRCVYECDNDVCDNQVVTLSWDADPVAAPGETPLQALSGRGSKTATLHMVAFTEKICTRFTHIYGVHGEMYADSSSITVTDFRTCKKTVHYPHIPEGGGHGDGDEGLTRQFVLAVDRVKNHGEKVSTAQREYVKCNLRDVIMSHSMVFAAEEARKGRKVVDFQHWFEKEVMIKLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1RLE8</accession>
    <accession>A0A098DZE3</accession>
    <name>I1RLE8_GIBZE</name>
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        <submittedName>
            <fullName evidence="4">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG04744.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T16215</name>
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    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323185.1">
        <property type="nucleotide sequence ID" value="XM_011324883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RLE8"/>
    <dbReference type="EnsemblFungi" id="CEF86712">
        <property type="protein sequence ID" value="CEF86712"/>
        <property type="gene ID" value="FGRRES_04744"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04744"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16215"/>
    <dbReference type="eggNOG" id="ENOG502SK56">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023307_0_1_1"/>
    <dbReference type="InParanoid" id="I1RLE8"/>
    <dbReference type="OrthoDB" id="160645at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054293">
        <property type="entry name" value="DUF7029"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22974">
        <property type="entry name" value="DUF7029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124375" evidence="2">
        <location>
            <begin position="22"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7029" evidence="3">
        <location>
            <begin position="175"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF86712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="553" mass="58986" checksum="B5FF1D7473923D60" modified="2012-06-13" version="1">MRTSFSSILFSLWLLSAGVVASHETHTSIDESCGCTVKYIVVEMPPQTVSSVIDTTTTTAAQETASIRAKTTPVRSKTSQTTIHASSTSHHNTTATFIPKTPVKVDCSNPKNAIPKKKIAMSYGDLSDDEVVQQNANTPKPSHKPSNGTFSTFNANKNTTTSKGPSGSIDMDLVMNHPAVVLDYIDAITSVECTADTIEVKFGKADVFNNAIKTWLDTFILITSNMGNCKAANGQAFYLVDRVTSDKSQKSITCYASEQKLEDIAETCEMSFNSIPATKLRKRLDLNPSLSLDFGTGLARDTVLFSEEPFVNIKAEKAEFSSTVSFSGRAKYNFWKFKMEHLYFDLNTRFSADVALSADVAAAWSRSILYDPDTLTFTVVEVPGILSLGPGIAFAVGVDVDTSAAVAVHAGAGISIPSGNVHLDALDGSKNSATGWEPQYTSYANISESVEVGLNASASLTVQLTFKLLGGLVDLSSGLTATPEFVNKFSLDAAQSGHASNGGAGGSISTPPGGCGVSLKSDFVFDLDGFATKWVKGNLYHVEVPITDICYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1RMU1</accession>
    <accession>A0A098E1R2</accession>
    <name>I1RMU1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG05291.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T17545</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323803.1">
        <property type="nucleotide sequence ID" value="XM_011325501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RMU1"/>
    <dbReference type="STRING" id="229533.I1RMU1"/>
    <dbReference type="EnsemblFungi" id="CEF88051">
        <property type="protein sequence ID" value="CEF88051"/>
        <property type="gene ID" value="FGRRES_05291"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05291"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17545"/>
    <dbReference type="eggNOG" id="ENOG502S47U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064532_0_0_1"/>
    <dbReference type="InParanoid" id="I1RMU1"/>
    <dbReference type="OrthoDB" id="4159154at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF7">
        <property type="entry name" value="SUR7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF88051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="308" mass="33561" checksum="428D696BC37C6761" modified="2012-06-13" version="1">MLSRFFVLFPMVLSMVAFILSMLCLFAGHKEGFMEDYSVARLNTSMIGHNVLDTDSSASTNDNKDDDGFFGAVKGKWNEVKDDIKGKINDVTGDIADELADTIGISEWYSIHVMATCDGQYKPNATSPGAGFNVTNCTNSAPEKRFNLTEMLDKQLSVGPFDLSLADINWPDDIQDSLDLLNTALFATFILYVIAVGLSGLAMLTSLAAFFLFSRRGVNAVNLVIAGLAALVLLISSILVTVAGKKGVNKLNDVGDDVGISASIGKKFLGLTWAAAALMIAAAIYWFVHLCLMRRERKREWKPRKGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1RPX7</accession>
    <name>I1RPX7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG06109.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T19505</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324733.1">
        <property type="nucleotide sequence ID" value="XM_011326431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RPX7"/>
    <dbReference type="STRING" id="229533.I1RPX7"/>
    <dbReference type="EnsemblFungi" id="CEF86056">
        <property type="protein sequence ID" value="CEF86056"/>
        <property type="gene ID" value="FGRRES_06109"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06109"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19505"/>
    <dbReference type="eggNOG" id="ENOG502S313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012822_0_0_1"/>
    <dbReference type="InParanoid" id="I1RPX7"/>
    <dbReference type="OrthoDB" id="5579731at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055264">
        <property type="entry name" value="BOD1/SHG1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28034:SF1">
        <property type="entry name" value="NUCLEOMORPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28034">
        <property type="entry name" value="SET1 COMPLEX COMPONENT SHG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05205">
        <property type="entry name" value="COMPASS-Shg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BOD1/SHG1" evidence="2">
        <location>
            <begin position="41"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF86056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="812" mass="97628" checksum="7B4CC072EC76B9B4" modified="2012-06-13" version="1">MATPGVEDSAMDIDKPSAPAPPKFKASDLPLPSATRAAIESLAHSFKKEGAYDTIRKQVWDKFEASDYEAQVTKSILEVAEQEIERNPQQLLTLDRRKAAALIDGALERSGVYQKAEDVISQLIDVGAIEERIRETRRADVGEEVAEVEKARGAKTDEEYAAETEARRAERERVREELRQKEEAIEEEKRRILKEERKKEEREREKAELKRQEERDERRRKREQEREERERLRDLEREKRHKERDRDRDRDRSRNTRDRDRGHDRDRDRDRRRDDDRHRDDRHKEKLAVSAELKEKLSKEEHERLEQEALADLLRESSKPSQKQEMEVDAALAPPPRKTGPVSAINPIRRERSSIAEGRKTSDAGLKAERADSETPSQAKKPAVDETKPGRSASRAVDRDGDRDRDRDRPRERDNRRDRRSNSPRRGQSGSRVQDRRDRSRSRTRQDRARSGVVRDERTARSRSRPKYDHYERSRSRRRERSRSRPRVADRRERSRSRARTDRRDRSRERRDRSRSRLRTERRDRTRSRTRRDPSRPRDVRLGGADHYDPRERDRDRDRPRERNERSPPRRRSRERTRDDRDQEKPRDKVPDKEREKEKEKPSDRRSPSRSLTTASAARPSSSKAQDELEEWKQEEVKKREKEAKAYLAAQKDARNKGLPIPGLDDKKSSGEISPDLRRRRVTDDIDRYMPGGREERRASRTRSRSRQRDATKDRDRERDRGDRDRDRDKLRGGDSYRERDRDRDRDRDRDRDRRDRDRDRSRERDRDRDRRDRDRDRDRDRERERSRDRRNRRDRSLSPRRERRDGSRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>I1RSI4</accession>
    <name>I1RSI4_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">FG07105.1</name>
        <name evidence="12" type="synonym">MCM7</name>
        <name evidence="14" type="ORF">FGRAMPH1_01T23971</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326807.1">
        <property type="nucleotide sequence ID" value="XM_011328505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RSI4"/>
    <dbReference type="FunCoup" id="I1RSI4">
        <property type="interactions" value="993"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RSI4"/>
    <dbReference type="EnsemblFungi" id="CEF85461">
        <property type="protein sequence ID" value="CEF85461"/>
        <property type="gene ID" value="FGRRES_07105"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07105"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23971"/>
    <dbReference type="eggNOG" id="KOG0482">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_1"/>
    <dbReference type="InParanoid" id="I1RSI4"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="PHI-base" id="PHI:1587"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033679">
        <property type="term" value="F:3'-5' DNA/RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904931">
        <property type="term" value="F:MCM complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="391"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CEF85461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="811" mass="90684" checksum="BFF88C6D54B5F845" modified="2012-06-13" version="1">MALREFKAPVSYEKQQHAFQEFLTGFKTSPEQTITTALGNITIGEDDFEDDLMDEDGQDVNQGQQAKERRSPQYKYKNMLQQLSDRTIDEATIDLDDLSTWESQAFEGEESLRLVDSIEMNTKHYVEIFSRAVDEVVPPASADTTFKDDVLDVLMARRQARNRELDEAAERDPTAADDKFPAELTRRYTLVFKPRSGTSSQPAKALAVRQVRGDHLGHLITVRAIATRVSDVKPIVQVSAYTCDRCGCEIFQPITDKQYGPLTMCPSEDCKQNQAKGQLNPSSRASKFLPFQEVKVQEMAEQVPIGQIPRSLTVFCYGTLVRQINPGDVVDISGIFLPTPYTGFKAMKAGLLTDTYLEAHHVLQHKKAYSEMIVDPTLVRRIEKYRQTGQVYELLAKSIAPEIFGHLDVKKALLLLLIGGVTKEMGDGMKIRGDINICLMGDPGVAKSQLLKYISKVAPRGVYTSGRGSSGVGLTAAVMRDPVTDEMVLEGGALVLADNGICCIDEFDKMDETDRTAIHEVMEQQTISISKAGISTTLNARTSILAAANPVYGRYNPRISPVENINLPAALLSRFDILFLLLDTPTRETDEQLAKHVTFVHMNSRHPDIGTDNVVFSPHEVRSYIAQARTYRPVVPANVSEYMIKTYVRMRDQQQRAEKKGKQFTHTTPRTLLGVVRLAQALARLRFSNEVVQDDVDEALRLVEASKESLNNELDAGRRNMKPTDRIYNLVKNLAETGQCRPDDAADDEDLGIELSMSKVRDRVLARFTLDQWQDALHEHTSVLNVWQTTGNGARLVFVVVGGENQNDDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1RSJ0</accession>
    <name>I1RSJ0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG07111.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T23983</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326813.1">
        <property type="nucleotide sequence ID" value="XM_011328511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RSJ0"/>
    <dbReference type="STRING" id="229533.I1RSJ0"/>
    <dbReference type="EnsemblFungi" id="CEF85097">
        <property type="protein sequence ID" value="CEF85097"/>
        <property type="gene ID" value="FGRRES_07111"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07111"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23983"/>
    <dbReference type="eggNOG" id="ENOG502SPEQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026597_0_0_1"/>
    <dbReference type="InParanoid" id="I1RSJ0"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF85097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="501" mass="55788" checksum="5A48A64DB692D041" modified="2012-06-13" version="1">MASSTNRPIPLSCFVCPETPRFSDVSHLLTHIASKGHLHQETQTKLKAHQDITAALNKRKMKQEMSMSPAIKLEGDELMSDFPLFPGFLDLEPDNSIQEEFVLGNDSMLLKGQVWPGMGKMDLADDETRKARNQKKPKSVIDKMKKASESIEPTQVVMSSKLEVERTRDVYDDTSSPVPGQEESTPPKRVSRPKRKKTTPLAEISGNVPKQRRRTTRGQKSNVGKTTRPKKEQGIQKEPEAFPSPERNKGVQDIFRDEVIRTASISEPPLPLSRGDHRLEPRNKHGARSMNGFFHSNIVSPTPQARDLAPRHLQARATPSSFRPESFPPGSFSQVEASYAMRDATIYNASSRLPFATADYSQFREPSSDHLRAAANYGFQLKQEEYPGSHTGDLTQGTNSPYIGMPGTNPLFSNDRSFLNSYNQRALGATFSPLSFPPVNQQPDYSHTGRDMKQQTHMCETMEASGLGGDQELNLDASWSLHDADSDMGFASGLAMDDQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RST9</accession>
    <accession>A0A098DPG0</accession>
    <name>I1RST9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG07223.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T24275</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326954.1">
        <property type="nucleotide sequence ID" value="XM_011328652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RST9"/>
    <dbReference type="STRING" id="229533.I1RST9"/>
    <dbReference type="EnsemblFungi" id="CEF83259">
        <property type="protein sequence ID" value="CEF83259"/>
        <property type="gene ID" value="FGRRES_07223"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07223"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24275"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_2_1"/>
    <dbReference type="InParanoid" id="I1RST9"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051935">
        <property type="entry name" value="HSDL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42808">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
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        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="GDHRDH"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF83259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="310" mass="33187" checksum="2F0FEAB1069EC6D9" modified="2012-06-13" version="1">MASKKPVALIVGASRGIGRQVAVDLASNGYAVVVAAKTISDTSNLPSPFPPNPNSSASTITTVAHEITLAGGDATAIQVDVRYPESVDSLIAQTISTYGRLDVLIYNSGAIFWAPVSSTPLKRFQLMQRVNPEGLYATIQAALPHLPSTGRIVVVSPPIYSRFFRGKTAYAMGKVGMSVLTKGLAMDFEREGKNDMAITSIWPAVAIESAATEQFTRKNPGEANDLRKATIFSDAILAILQASPSVVNGELLLDEDFLREHAGVTDFSKYNVVPGTAPRRIMPASLPDLTVAEQSDEGKRYDSTKAKFKL</sequence>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1RTJ7</accession>
    <name>I1RTJ7_GIBZE</name>
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        <submittedName>
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        <name evidence="2" type="ORF">FGRAMPH1_01T24971</name>
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    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327281.1">
        <property type="nucleotide sequence ID" value="XM_011328979.1"/>
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    <dbReference type="AlphaFoldDB" id="I1RTJ7"/>
    <dbReference type="STRING" id="229533.I1RTJ7"/>
    <dbReference type="EnsemblFungi" id="CEF83973">
        <property type="protein sequence ID" value="CEF83973"/>
        <property type="gene ID" value="FGRRES_07505"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07505"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24971"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_009600_18_1_1"/>
    <dbReference type="InParanoid" id="I1RTJ7"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Amidase"/>
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        <property type="entry name" value="Amidase_dom"/>
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        <property type="entry name" value="AS_sf"/>
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    <dbReference type="PANTHER" id="PTHR11895:SF170">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="96"/>
            <end position="511"/>
        </location>
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    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF83973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="526" mass="56321" checksum="42C0D874C281CC01" modified="2012-06-13" version="1">MSVFFKEILPGNPVKKGDVEALLERLELTIRPEDSADYQLLLAAVHDCAERISSLPDYQPIPDIERFPRQDVRLPEKHEQAFGHAWAHRFTIHGDKTSRSSLAGKSVCLKDCIAVAGVPQFFGSDAFPAWTPSTDATVVTRSLEAGAVITGTATCENFCNSTSSFTSAQGTIDNPRKAGYSAGGSTSGGAALVTSSLADIAIGTDQGGSIRVPASLCGCVGFKPTHGLVPYTGISSGDQIDDHAGPLARTVDDIAACLDTIAGYDGIDDRSLGAAPHGSFGFLESLNGASLQGVRIGVLEEGYDDNSLIQPGVKKIFLETVNRLESLGAIIQDISIPIHKEGPSIWTIQQRISGSAGILGQANGRRGLYLTEFEQARLPWTASQFEKLFPSTKNTVINGLYLQRTFPGLYSKTVNIGRQMRDAYEAKFKEYDAIIMPTTPFVAPRHGSRESVLKSFEPSIGMTNNTAIFNVTGQPALSLPVGWSQAADDESVMLPVGLQIVGGLWEEKKVLRIAKALESSLGSFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>I1RUI2</accession>
    <name>I1RUI2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG07875.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T25877</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327706.1">
        <property type="nucleotide sequence ID" value="XM_011329404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RUI2"/>
    <dbReference type="FunCoup" id="I1RUI2">
        <property type="interactions" value="706"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RUI2"/>
    <dbReference type="EnsemblFungi" id="CEF84499">
        <property type="protein sequence ID" value="CEF84499"/>
        <property type="gene ID" value="FGRRES_07875"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07875"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25877"/>
    <dbReference type="eggNOG" id="KOG0756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_5_1_1"/>
    <dbReference type="InParanoid" id="I1RUI2"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000092">
        <property type="entry name" value="Mitochondrial tricarboxylate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000064">
        <property type="entry name" value="Mitochondrial tricarboxylate transporter (Ctp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="14"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="104"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="201"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF84499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="298" mass="32347" checksum="9C964EE9BE432A79" modified="2012-06-13" version="1">MASTAQPAEKKKQPSPLRSVIAGSTAGAIEIAITYPAEFAKTRSQLNRRLGEGQKLPWPPFGSQWYAGCTTLIIGNAAKAGIRFVAFDQYKALLVDENGKLSGPRTVLAGFGAGVTESLLAVTPTESIKTTLIDDRKSAKPRMRGFLHAVPIIARERGLRGFFQGFAPTTARQAANSATRFTAYNFFKQMAESYTAPGEKLGVVGTFAIGGLAGLITVYVTQPLDTIKTRMQSIEARTTYGNSFKCATSIFKQEGVLTFWSGALPRLARLIVSGGLVFTAYEQIQVWFTKIDPEEKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1RUN0</accession>
    <name>I1RUN0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG07929.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T26009</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327770.1">
        <property type="nucleotide sequence ID" value="XM_011329468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RUN0"/>
    <dbReference type="STRING" id="229533.I1RUN0"/>
    <dbReference type="EnsemblFungi" id="CEF85051">
        <property type="protein sequence ID" value="CEF85051"/>
        <property type="gene ID" value="FGRRES_07929"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07929"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26009"/>
    <dbReference type="eggNOG" id="ENOG502QWQE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033097_0_0_1"/>
    <dbReference type="InParanoid" id="I1RUN0"/>
    <dbReference type="OrthoDB" id="5308502at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018830">
        <property type="entry name" value="DUF2434"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10361">
        <property type="entry name" value="DUF2434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF85051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="583" mass="66730" checksum="1D526E76C9DBA22F" modified="2012-06-13" version="1">MEGLRDAFAHISARAVKDWPAGSKGNTSETIISNVPFNLTTLKYFNYTYYSNETVSNGSKCYLTFDPYTPAYVFPNGSWTNATKCYTAIEHIKTRGFVGIGFAVAFGIALVLNLTVLAKHGKIYTPRDSRFYPVGRRWQWYWALFTSAAALISLFVGVDIDRYYLQELPITVNVFFWYLLCTGTVALTWEAVRHWGSWQERKFVDPDPFIVKDNDRRAKVEFWLPLWFYLWLWLNFFMVVPRSWKFTQLQHSEEQTLAKAVPGATNTRFKAGALCLVVAWLTIVFSLYHSIKHYKPRHRGVFNRAVGFIRYVPFRFWLILPLSAATIAYQGFISWEFKYSIVKYNGNIPVIYCWGFLPSLLILFTQYFYGFFTPNEDKELVRLRRERGEMLDRELGLVNKPAWWKRVRGDHLLTFKDKLTRNVHEIGGGHATGRRIEGDAERDLREEALAAARNDEGFEMSHMHRPLDAANNPRVGRAGAASISSNASRLSYVQPYTGKNDRRRHERNMQAAAGILFPNNLAEERARREAQLGLDGPAPPPYTDGQGRGRAPGRPGSTGRSNSTETTNSITAPPQQIKSMLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RV53</accession>
    <accession>A0A098DEL0</accession>
    <name>I1RV53_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG08115.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T09149</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320703.1">
        <property type="nucleotide sequence ID" value="XM_011322401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RV53"/>
    <dbReference type="EnsemblFungi" id="CEF76376">
        <property type="protein sequence ID" value="CEF76376"/>
        <property type="gene ID" value="FGRRES_08115"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08115"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09149"/>
    <dbReference type="eggNOG" id="ENOG502QXBB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029266_0_0_1"/>
    <dbReference type="InParanoid" id="I1RV53"/>
    <dbReference type="OrthoDB" id="3592035at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048527">
        <property type="entry name" value="Sde182_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011483">
        <property type="entry name" value="Sde182_NH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21027">
        <property type="entry name" value="Sde0182_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07632">
        <property type="entry name" value="Sde182_NH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124567" evidence="1">
        <location>
            <begin position="21"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulose-binding Sde182 nucleoside hydrolase-like" evidence="2">
        <location>
            <begin position="38"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulose-binding Sde182 C-terminal" evidence="3">
        <location>
            <begin position="393"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF76376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="495" mass="55341" checksum="40A63E9E815DA237" modified="2012-06-13" version="1">MFTQALGAFALFNCLPLTQATPISEKQCETARWEHKPKLFVLTDISNEPDDQMSLVRLLTYANEIDIQGIAVTTSTWMPDKIDYESVVGVLGGYKKVVDNLNANVPSHASYPSYKYMLDRIHKGHPVYGRKSLNMTLSDGAKALTKAADAASTDDPLTVSIWGGSAILAESLQHVSRTRNEAAVDSFVEKLRVYAISDQDDTGVWIRLRYPQLMYVTSLHGFSEYTDATWNGISGEEYRHFDQGGPDSSIVSNDWLEKNIRLGPLGSHYLNWSFIMEGDTPAFLPLVQNGLGDVNRPDFGSWGGRYTLLDHSGQSKVYADTTDYVVGKNGKSFTSKFATIWRWREDYQFDFAARMKWSVNSNYSENNHQPVAIVNGSCGPASLKLKYKPGQSIVLDASDSWDPDGDELKYDWFHYREPGGAYGRGLEGFDPSLKMKPILTTQSPNVNITNLTEDGSIVKLETAKKLNDTLHIILALRDATEQPLATYRRVILEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1RVI5</accession>
    <accession>A0A098DF37</accession>
    <name>I1RVI5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG08263.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T09507</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320537.1">
        <property type="nucleotide sequence ID" value="XM_011322235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RVI5"/>
    <dbReference type="EnsemblFungi" id="CEF76556">
        <property type="protein sequence ID" value="CEF76556"/>
        <property type="gene ID" value="FGRRES_08263"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08263"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09507"/>
    <dbReference type="eggNOG" id="ENOG502R99C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_495267_0_0_1"/>
    <dbReference type="InParanoid" id="I1RVI5"/>
    <dbReference type="OrthoDB" id="4719016at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41773">
        <property type="entry name" value="GTP PYROPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41773:SF1">
        <property type="entry name" value="RELA_SPOT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RelA/SpoT" evidence="1">
        <location>
            <begin position="44"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="550" mass="63666" checksum="4EB4C077B35CB5A4" modified="2012-06-13" version="1">MDVIDEFITKFQHERDQWELLKDRAIEICNSTLRDINTIGIVTGRVKTAESLRKKLNTRNASKRYLDEDSVLKDQLDFVGLRIALYFPSQKQHVFTQLQEVFRYEALRPFDRDWKPREPGIYQNLFGQYVADHLWVSLRTEDQGLAGPHAKQPFEIQLRSVLMDAWAGISHDLQYKALSGHLTGTELKLLDALKGHVEVGELMLEQLYQVHRKRIETEKEPITSVQDLRYIILDSIPGVQASEVNLGDLDALFLVLQAFQCANPHTARVLLHEYTKANLRLQLDDFEETFDPLPATVSFFLLEKLLPHVKDHGQSFRQVAEVIRARQQRPLHDSRYWQSLLWLSCQILDRAKSRNVFPSGAQVRKYAYIWCTEHHHRPPLSLARSDDNLIQCLAIGHEHPARGLEFLAELSFLGLGPTVPEYMEVHDAGHEDNRFNVIAKTLLLLYERYPEEWKEAISEYTRSLSEVDATTNRFLHLVDVATWLMSIRAREHLVHLLDIWPLDDDTNVWDNLDLQSGLETTKDVPSGLLLQLLKGEKHGYFMLKEGESKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1RVJ8</accession>
    <name>I1RVJ8_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol-phosphate mannosyltransferase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG08277.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T09545</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320518.1">
        <property type="nucleotide sequence ID" value="XM_011322216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RVJ8"/>
    <dbReference type="STRING" id="229533.I1RVJ8"/>
    <dbReference type="EnsemblFungi" id="CEF76575">
        <property type="protein sequence ID" value="CEF76575"/>
        <property type="gene ID" value="FGRRES_08277"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08277"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09545"/>
    <dbReference type="eggNOG" id="KOG4841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150782_1_1_1"/>
    <dbReference type="InParanoid" id="I1RVJ8"/>
    <dbReference type="OrthoDB" id="2014333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013174">
        <property type="entry name" value="DPM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433:SF0">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08285">
        <property type="entry name" value="DPM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF76575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="92" mass="10264" checksum="3E1C2BBB17F9C477" modified="2012-06-13" version="1">MTRAQQTISLALLVSSLYLALFLELIPLPPLIQEQIVPVLPFWALVSFGAYLLFRLGFGILTFNDVPNAHKELTAEIEQAKVELRKLGVTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>I1RVN0</accession>
    <accession>A0A098DCD7</accession>
    <name>I1RVN0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG08312.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T09633</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320479.1">
        <property type="nucleotide sequence ID" value="XM_011322177.1"/>
    </dbReference>
    <dbReference type="SMR" id="I1RVN0"/>
    <dbReference type="FunCoup" id="I1RVN0">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RVN0"/>
    <dbReference type="EnsemblFungi" id="CEF76619">
        <property type="protein sequence ID" value="CEF76619"/>
        <property type="gene ID" value="FGRRES_08312"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08312"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09633"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="InParanoid" id="I1RVN0"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000881">
        <property type="entry name" value="ABC multidrug transporter A-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="636"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="776"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1204"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1276"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1326"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1355"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1385"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1480"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="161"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="868"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF76619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1517" mass="168711" checksum="8C2747580B8E3A8F" modified="2012-06-13" version="1">MSALYGINANNDATAAKQGAPGAGSTGNNVPLADQHQNSTDEAINEKPPTSSPADTLGKGDDEDDSEMERRTSIVQALARSYSHASASHPGGQNPFQAGEDSPLNPNSPNFNAREWAKSIVALVRQDGNSFRSAGVCYQNLNVYGYGGASDYQSDVGNVWLGLEDVIGRVTGRSQQRIDILRNFDGVVHAGEMLVVLGPPGAGCSTTLKTIAGELNGIYVDDGSYFNYQGLSAKEMHSHHRGEAIYTAEIDVHFPMLSVGDTLTFAARARQPRELPQGLNRNDFADHLRDVVMAMFGISHTANTRVGNEYIRGVSGGERKRVTISEAALSGAPLQCWDNSTRGLDSANAIEFCKTLRLQTELFNNTAVVSIYQSPQSAYDLFDKATVIYEGRQIFFGRADAAKQYFVNLGFECPARQTTPDFLTSMTAPNERIVRDGFKGKVPRTPDEFATAWKNSAEYAALQVEIENYKVAHPIDGPDAEAFRASKQAQQAKSQRLKSPFTLSYMQQIQLCLWRGWLRLKGDPAITVGSLIGNFVMALIIGSVFYNLSETSSSFFQRGALLFFAVLMNAFASALEILVLYAQRPIVEKHSRYALYHPSAEAIASMLCDLPYKVANTIVFNLTLYFMTNLKREPGAFFFFILMSFVVVLVMSMIFRTIASASRSLFQALVPAAILILDLVIFTGFVIPKRYMLGWCKWLYYIDPIAYAFEAVVVNEFHNRDYECDQFIPNPGVTGYADVPSDSRVCSAVGAQPGRSAVNGDRYAEMQFGYKWENRWRNFGIVIAWIVLFTITYMTAAELVSEKKSKGEVLVYRRGHKPAAVANAEKKHSDPEAAMAHIGPMVTAERTRSRASGTKQAGGMLQEQTSVFQWQDVCYEVKIKDETRRILDHVDGWVKPGTLTALMGVSGAGKTTLLDCLADRTSMGVITGEMLVDGKPRDMSFQRKTGYVQQQDLHLQTSTVREALNFSALLRQPAHVPKQEKLDYVEQVIKLLDMEEYADAVVGVPGEGLNVEQRKRLTIGVELAAKPPLLLFVDEPTSGLDSQTSWAILDLLEKLTNAGQAILCTIHQPSAMLFQRFDRLLFLAKGGKTVYFGDIGENSHIMTSYFERMSGHTCPPEANPAEWMLEVIGAAPGSHTELDWFQTWRDSPECQEVKAELERIKREKEGVEDTDVDDGSYREFAAPFMVQFKEVLYRVFQQYWRTPVYIYSKAALCSLVALFIGFVFFKAPNTIQGLQNQMFAIFNLLTIFGQLVQQSMPQFVIQRSLYEVRERPSKVYSWKIFMLSQLIVELPWNSLMAVIMFFGWYYPVGLYQNASDAGQTTERGALMFLLLLAFLIFTATFSTMIIAGFETAEGGANVANLLFMLCLIFCGVLAGKDTLPGFWKFMYYVSPFTYLVGGMLATGVANTDVKCASNELVPIVPPNGSTCVEYMGDYISAVGGYFVDPDATQNCEFCTIDKTNTFLAGVNIDYADRWRNFGLLWVYIAFNMAFALFIYWLARMPKKSFKKAEKKKAAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I1RVR2</accession>
    <accession>A0A098DDY9</accession>
    <name>I1RVR2_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG08352.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T09735</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320431.1">
        <property type="nucleotide sequence ID" value="XM_011322129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RVR2"/>
    <dbReference type="FunCoup" id="I1RVR2">
        <property type="interactions" value="721"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RVR2"/>
    <dbReference type="EnsemblFungi" id="CEF76670">
        <property type="protein sequence ID" value="CEF76670"/>
        <property type="gene ID" value="FGRRES_08352"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08352"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09735"/>
    <dbReference type="eggNOG" id="KOG2040">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_3_2_1"/>
    <dbReference type="InParanoid" id="I1RVR2"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000007">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003346">
        <property type="entry name" value="PRK04366.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="68"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="543"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="874"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF76670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1054" mass="115305" checksum="518F58AD40CE8057" modified="2012-06-13" version="1">MMSATRIGQRLARQSRRSPITLQPRLTQTIRLNAVSSRAFSVTATTQAPRFVESQSSTKLHEHELFSRRHIGSESSEQTEMLKMLDPPVSSMEEFLEQTIPPQVRRKQKGLNLVEQWYEGGAETAVPVNGRTEHYIQKEMRKLAKNNKVYESFIGAGYYGTLVPAVIQRNVLENPAWYTSYTPYQAEISQGRLQSLLNFQTLITDLTGLDIANASVLDEATAAAEAMTMSMANAPKGKGQKTFVVSENCHPQTISVLQSRAEGFNIKLVIGDVLADNSKLVREVEGDLIGTLIQYPDTHGGVHDYQALADIVHEKKALLSASTDLLALTMLKPPGDFGADIAIGNSQRFGVPLGYGGPHAAFFATSEKYKRKIPGRLVGVSKDRLGKPALRLALQTREQHIRREKATSNICTAQALLANMSAFYAVYHGPKGLKTIAEDIWSKTRLAQSLILEKGEFKLHTEGLREDGSVLFDTVTLKGSPEAIAKVHEKADSQSINLRRVADDKVGFSLHEGVTLESLGNLVKIFGVSESDFNAALESDKAKFLNDEIPASLQRKSAYLEQPVFNQYHTETELLRYIYHLQSKDVSLVHSMIPLGSCTMKLNATTEMLPVSDPGINNIHPFAPVEQASGYQALISSLAKNLSEITGMDATTLQPNSGAQGEFAGLRCIKAYHEARSGEKRKVCLIPVSAHGTNPASAAMAGMKVVTVKCDGKTGNLDIEDLKAKCVKHADELAAIMVTYPSTFGVFEPEIKQVCDLVHEHGGLVYMDGANMNAQIGLCSPGDIGADVCHLNLHKTFCIPHGGGGPGVGPIAVKKHLAPYLPGHPEIDPQRIGAERDSTAVAPISAAPWGSASILPISHTYILMMGGDGLTKQTGTALLNANYIMSRLLPHYKVVYTNAQGRCAHEFILDVRPFKDTAGVEVADIAKRLADYGFHSPTMSFPVSGTLMIEPTESESRAELDRFCDALIQIRKEIADIESGKVPRKNNILTNAPHPQEDLLSSEWDRPYTREEAAYPLPWLREKKMWPSVGRVDDAYGDTNLFCTCPPVEGSEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1RW15</accession>
    <name>I1RW15_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG08467.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T10039</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320298.1">
        <property type="nucleotide sequence ID" value="XM_011321996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RW15"/>
    <dbReference type="FunCoup" id="I1RW15">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RW15"/>
    <dbReference type="EnsemblFungi" id="CEF76822">
        <property type="protein sequence ID" value="CEF76822"/>
        <property type="gene ID" value="FGRRES_08467"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08467"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10039"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018149_3_0_1"/>
    <dbReference type="InParanoid" id="I1RW15"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="83"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF76822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="378" mass="42758" checksum="DF6B6A6C54117ADA" modified="2012-06-13" version="1">MASTSSLRYLTMEELNKNALEQFVYQPVGRDMIAYLAQAAHNVIACDSTLMPPAPADARHNIPTPPRSPEPRTVRSEDGALPTLEEFITQLVVSSNVQVPTLMSTLVYLGRLKSKLQPMARGLRCTAHRIFLAALILSAKYLNDSSPKNKHWANYSHITTECYNFGFSRTEVNLMEKQLLFLLEWDLRITEQDLYRDLDDFLEPLRHKIAERHARKIRHREEKRRQKELYAASARYPSPASSRGHSRSRGSTPEHARNLSGPVTPPGLSYSSSSSSYASSVSSGRAYSQATTPLEPSEPEPYYYESQQGSLYDSPVQIVPDVDYPKAHMASGRMLPYEITADEYQQYQHYQDASSKKQQQRSRRGMWGRLLGGGVAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1RX18</accession>
    <accession>A0A098DFT0</accession>
    <name>I1RX18_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG08861.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T11019</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319851.1">
        <property type="nucleotide sequence ID" value="XM_011321549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RX18"/>
    <dbReference type="STRING" id="229533.I1RX18"/>
    <dbReference type="EnsemblFungi" id="CEF77312">
        <property type="protein sequence ID" value="CEF77312"/>
        <property type="gene ID" value="FGRRES_08861"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08861"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11019"/>
    <dbReference type="eggNOG" id="ENOG502SHX3">
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    <dbReference type="HOGENOM" id="CLU_004804_2_3_1"/>
    <dbReference type="InParanoid" id="I1RX18"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="PHI-base" id="PHI:1744"/>
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        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0000981">
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
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    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF77312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="566" mass="64520" checksum="AE48C46D15277F38" modified="2012-06-13" version="1">MQHSKERHNTARLGKKNCTECRRRKVSCVFDDQRRCRQCLTHSLLCESQQVPPSEQSSHDKDRIIQELNQFVTQVESRMVEMQESIRVLTSQLDKCNVAGSADKSPHQQEVHIPENSQLQIPKETLANERSQTPMSQLELIPGDIIPNSQTLEKILDYSDQLLQSLMLWPFAIIHNDQEDRGIFCNRDKIFDALKSRDIGLASKCLIWTSLLLSQLPKDFKDAETGLPLCPEKFIDRILTQVSILYLADCTPACSIDSIEALVLQYELFVAIGRPSTAWKCIRAGIENALLLGLHLRPSLLWDALWIRDRQMSLIIGLPYGTLNMDVQTTELDTLRKIGLVSGFISDRDRLRQDTPFSIMQSIVEGMKELKIMIPDEWAEADLNLAFSPIEHAIMRLYKHKLNIMIHLPYSQFAGYDKQFEYTRVEVLESAEGALDAHGDIRSLQEKPLRCDLYDFLAFNAALVLFVDLVAKETPRTIEEEDHIWTVIMKFVSRLRKTGEVLGEQAADVLDDLYAAYKDETGKELIDDWTEIDSSGTYGWRGMLASMEAGGMDGMATTMLDASRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1RXI9</accession>
    <accession>A0A098DW29</accession>
    <name>I1RXI9_GIBZE</name>
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        <submittedName>
            <fullName evidence="8">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG09060.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T28017</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328734.1">
        <property type="nucleotide sequence ID" value="XM_011330432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RXI9"/>
    <dbReference type="EnsemblFungi" id="CEF85562">
        <property type="protein sequence ID" value="CEF85562"/>
        <property type="gene ID" value="FGRRES_09060"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09060"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G28017"/>
    <dbReference type="eggNOG" id="KOG0253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_52_1_1"/>
    <dbReference type="InParanoid" id="I1RXI9"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="381"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="450"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="490"/>
            <end position="508"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="528"/>
            <end position="547"/>
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    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="62"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF85562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="558" mass="61597" checksum="85ACCC6688B59B5E" modified="2012-06-13" version="1">MAESTKFADDIIPNEEIENAGPYSRRSNFLHGLEGLTLYEKKCVLINREIDRQGMGKYQWYIWSLCGFGYLLDLLWAQAFGLVLGPLQQEMGFGDNESGNISTSFNAGLTAGAFVWGFLADIIGRRWAFNLTCLFSSIFGICLGASNNYNTFLVLTAFVGFGVGGNIPIDTTITLEFIPQNKRFLLACLSVFQPIGVVICSAIAFGFIPVYACSPNFSEPDALISCNNASGGERCCSRGDNMGWRYLLFTIGGITLFIFILRFFVFNFRETPKYLVYRGRDEEAINTLRHMAEINKKECGITVEMFESLQGDESSVGSGDSATPALGAGKKQLNLKWSKKVKLELYRYKMLFSSAKMTRLTILVWLTYIMDYWGFTVAGFYLPSILALKNGAVSVSLKSTYAAYIYTYAPGIVGVLVGATLYRVPAFGRKWTMVLSSALMGISIILFSTVDTRAKNEGLFTMEYFFQSMFNAVLYGWTPEAFPAPIRGTACGLAGFWGRLFGIVSPLIAQHLYGRTTGDGGQGDINSVLYLAGGVMLGCVITTALLPSDMMETRDERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZD6</accession>
    <name>I1RZD6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG09775.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T26307</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF82813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327919.1">
        <property type="nucleotide sequence ID" value="XM_011329617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZD6"/>
    <dbReference type="FunCoup" id="I1RZD6">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RZD6"/>
    <dbReference type="EnsemblFungi" id="CEF82813">
        <property type="protein sequence ID" value="CEF82813"/>
        <property type="gene ID" value="FGRRES_09775_M"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09775"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26307"/>
    <dbReference type="eggNOG" id="KOG1736">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087056_0_0_1"/>
    <dbReference type="InParanoid" id="I1RZD6"/>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11283">
        <property type="entry name" value="ADF_GMF-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000048">
        <property type="entry name" value="Putative gmf family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001788">
        <property type="entry name" value="GMF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF82813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF82813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="142" mass="16261" checksum="AF3BB671FD61FD7E" modified="2012-06-13" version="1">MASESRLYTFSGESKDHLRKFRLTTSRAKGPQAVIYLIDKHTYEIRQDEDKTVYTSLEEVGDDLPDHAPRFILLSYPLTMGDGRLSVPYVLLFYLPVTCNAEIRMLYAGAKELMRNTAEVGRIIDIETAEELEEIPDKLKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZU1</accession>
    <name>I1RZU1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG09946.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T06895</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318854.1">
        <property type="nucleotide sequence ID" value="XM_011320552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZU1"/>
    <dbReference type="EnsemblFungi" id="CEF75252">
        <property type="protein sequence ID" value="CEF75252"/>
        <property type="gene ID" value="FGRRES_09946"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09946"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06895"/>
    <dbReference type="eggNOG" id="ENOG502QSRA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048481_0_0_1"/>
    <dbReference type="InParanoid" id="I1RZU1"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14474">
        <property type="entry name" value="SPX_YDR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="7">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF75252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="463" mass="51949" checksum="89E05828623F9BC5" modified="2012-06-13" version="1">MKFGEHLERESVPEWNLHNLDYNSIKHEIKMHTTRDQATAMAIPGQTDEALSRFEDGLYMELGRQHERLQLFVSSKADEISRRLEYLAKNINRWASKNRDGLADDSAIKHQRRFTKYERELVRCGSDIHALERFVNAQAVAFRKITKKYKKWTGSTTLATRLYENILSDPKSFTRRDFSSLQQRYDNITCTLNAAAPVLSEPSSPESASHSYRRQSLSGSINSAHRHCANRSQPTFEFLPPAQIEEPVKYWNEYDNGSECADDDGAYAIYINPGESTNFPGFDYLHGIFTVPLNKAKGWFKHSKPGERQSLLGANHSSYQYSSTVFNSSESDEEAGYASSDGFPASGYATHYALPSLSQQQAHLYREKALFWGTVGSFAVSFLLILVAGTLISTGRHKLRAEVDAGVTVGVVASLFTSCSALGMTLYRHDQLSLPHLMAVWTTFIASCILNGMLLILVVGNSP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-04-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1S0E2</accession>
    <accession>A0A0E0RWA0</accession>
    <name>WETA_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Developmental regulatory protein wetA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">wetA</name>
        <name type="ORF">FGRRES_17727</name>
        <name type="ORF">FGSG_10166</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2014" name="J. Microbiol." volume="52" first="930" last="939">
            <title>FgFlbD regulates hyphal differentiation required for sexual and asexual reproduction in the ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="Son H."/>
                <person name="Kim M.G."/>
                <person name="Chae S.K."/>
                <person name="Lee Y.W."/>
            </authorList>
            <dbReference type="PubMed" id="25277408"/>
            <dbReference type="DOI" id="10.1007/s12275-014-4384-6"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2014" name="Eukaryot. Cell" volume="13" first="87" last="98">
            <title>WetA is required for conidiogenesis and conidium maturation in the ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="Son H."/>
                <person name="Kim M.G."/>
                <person name="Min K."/>
                <person name="Lim J.Y."/>
                <person name="Choi G.J."/>
                <person name="Kim J.C."/>
                <person name="Chae S.K."/>
                <person name="Lee Y.W."/>
            </authorList>
            <dbReference type="PubMed" id="24186953"/>
            <dbReference type="DOI" id="10.1128/EC.00220-13"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="1 3">AbaA and wetA are pivotal regulators of conidiophore development and conidium maturation (By similarity). They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes (By similarity). Functions to maintain conidial dormancy by suppressing microcycle conidiation (PubMed:24186953).</text>
    </comment>
    <comment type="induction">
        <text evidence="4">Expression is positively regulated by flbD (PubMed:25277408).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Results in abnormal production of conidiophores and conidia, including longer conidia with fewer septa, conidia sensitivity to acute stresses such as oxidative stress and heat stress, and vigorous generation of single-celled conidia through autophagy-dependent microcycle conidiation (PubMed:24186953). Reduces the survival rate of aged conidia (PubMed:24186953).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the wetA family.</text>
    </comment>
    <comment type="sequence caution" evidence="6">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ESU16845" version="1"/>
        </conflict>
        <text>Truncated N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="DS231669">
        <property type="protein sequence ID" value="ESU16845.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319107.1">
        <property type="nucleotide sequence ID" value="XM_011320805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S0E2"/>
    <dbReference type="SMR" id="I1S0E2"/>
    <dbReference type="STRING" id="229533.I1S0E2"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T07441">
        <property type="protein sequence ID" value="FGRAMPH1_01T07441-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G07441"/>
    </dbReference>
    <dbReference type="GeneID" id="23557084"/>
    <dbReference type="KEGG" id="fgr:FGSG_10166"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07441"/>
    <dbReference type="eggNOG" id="ENOG502S8IT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100289_0_0_1"/>
    <dbReference type="InParanoid" id="I1S0E2"/>
    <dbReference type="OrthoDB" id="2575228at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040112">
        <property type="entry name" value="WetA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934:SF25">
        <property type="entry name" value="DEVELOPMENTAL REGULATORY PROTEIN WETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934">
        <property type="entry name" value="PROTEIN ESC1/WETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0183">Conidiation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0749">Sporulation</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000435928" description="Developmental regulatory protein wetA">
        <location>
            <begin position="1"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="447"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="502"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P22022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="24186953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="25277408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="24186953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ESU16845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000009057"/>
        </source>
    </evidence>
    <sequence length="608" mass="66196" checksum="4509D2540A5DEE48" modified="2016-04-13" version="2">MPMASWTLPYRVEAVDRDPGFYWQEIEDGHNNDGSADFFGQFINFDSEIPSSMADHHGHNPGMPTLADGLMLDHPSESTASASSGVSTTEDEFDLFSCSSQVDATVPSQPGSSAAPGASHDVDPRSLALADSSGLMVEKHSMVPRVSMSDPELPRVDGISLQSSPGRRVPVSQPSSPTPPNTMTRKPNKFVEALSSTIRKASKLRKPRKPIAMDRPGSPTMDNPPRALRLQHHEYNGNDVFPPSPTTCGPDSTNFVHGFCDDPFDEIPQQHPNNMRFFKTNGIHTPAESPGIKTEPGMYQPEMAGQAVWPHQQHPHPHPHPHHPQAHTHPHPHPHPHPHQQAVAGHPQHAVPVVGPAPETWPGHEYMAQNAHQSGWWDLNLLNQNGEYVVVDPQQQKNANLNLAMHAQHAELPYEYQVHDPNSAGLMIHMPQPRNDSTPAHDLALNAQTYLPPPPPIPPTTERHRPPRAPSSGARHLSCSPIRKTRQPSIPPTPTTVHSRHSSNGSVASARSASGRGMVPGTPTAMRKQRRSRDSSGGSVGDIGFVNFTPSDGGLLMTGVAPSGSSKTKARREREAMERRRRLSEAAMKAVQAAGGDVDKLMEQGFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I1S0M2</accession>
    <name>I1S0M2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T07659</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319207.1">
        <property type="nucleotide sequence ID" value="XM_011320905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S0M2"/>
    <dbReference type="FunCoup" id="I1S0M2">
        <property type="interactions" value="1074"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1S0M2"/>
    <dbReference type="MEROPS" id="T01.971"/>
    <dbReference type="KEGG" id="fgr:FGSG_10255"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07659"/>
    <dbReference type="eggNOG" id="KOG0182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_1"/>
    <dbReference type="InParanoid" id="I1S0M2"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000026">
        <property type="entry name" value="Proteasome subunit alpha type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SCB64587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="253" mass="27779" checksum="B3CBA2B909C14434" modified="2012-06-13" version="1">MSAGAYDRHITIFADNGRLYQVEYAFKAITAANIMSVGVRGKDCAVVLSQKKVPDKLMDPASVTHIFQLSPSVGCVITGSIADARAFAQRAQGEAAEFRYKYGYEMPADALAKRLANISQVYTQRAYMRPYGVATTLISLDSEYGPQLFKCDPAGYYIGYKGTAAGPKQQEALNHLEKKLRNKEHAEGSWEEVVELAITTLSTVLSMDFKKGEIEIGIVGGPRPEGQEGTYSGFRTLTEDEIDDRLQAIAEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>I1S0Q4</accession>
    <name>I1S0Q4_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="3 13">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">FG10290.1</name>
        <name evidence="16" type="ORF">FGRAMPH1_01T07745</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Adenine glycosylase active on G-A mispairs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="3 13"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319249.1">
        <property type="nucleotide sequence ID" value="XM_011320947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S0Q4"/>
    <dbReference type="STRING" id="229533.I1S0Q4"/>
    <dbReference type="EnsemblFungi" id="CEF75676">
        <property type="protein sequence ID" value="CEF75676"/>
        <property type="gene ID" value="FGRRES_10290"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10290"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07745"/>
    <dbReference type="eggNOG" id="KOG2457">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_0_0_1"/>
    <dbReference type="InParanoid" id="I1S0Q4"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035485">
        <property type="term" value="F:adenine/guanine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032357">
        <property type="term" value="F:oxidized purine DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03431">
        <property type="entry name" value="NUDIX_DNA_Glycosylase_C-MutY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000002">
        <property type="entry name" value="Adenine DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944:SF1">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14815">
        <property type="entry name" value="NUDIX_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="15">
        <location>
            <begin position="180"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="14"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CEF75676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="624" mass="69078" checksum="61B2EF4465A1D0BC" modified="2012-06-13" version="1">MDKFLIKAPIRTTRLSAASASRKITSQLGPDDELAVPDEKRALKRPSPRPDEDFDASESEGDATTENDTKQPAPKKRKTQPSRSKAETSKIHESLFSSKGETSPTPCTPPSRQHQITYHRPLMLKEPSSRQALLTWFDGVSTKRSMPWRKAWISPDDHGQDELRDLLERRAYEVWISEIMLQQTRVAVVIDYWNKWMDKWPTIHDLAAASADDVLSAWRGLGYYSRATRIHEAAKLVVNDSVMKGLLPSNTKDLEDKVPGVGRYTAGAISSIVFGRAAPMVDGNVLRVLSRQLGLFGNVKSNKTVIDTLWAAADALVQAIARDGTDKQEGEEVETSDRPGRWGQALMELGSTICIPKPNCSECPITSTCRVYAEGKTLVSSKNQDTKIGDIEDMCDLCESLEEETLDETEVKVEDTKASKKTTAKGGQGKQMTLSAFAFKGPTEDKPAAAKANAAISPRDMETIVDHARKFPLKVIKKAVREEETLVCVIRRADGQYLIQKRPEKGLLAGLWEFPSHILQDAKEGSTPAKRRSKALAHVSKLAGEHGGKSAKPKHVADLGSVPWLFSHIKLTMHVHLFTLEDGSLDDTKSLTKDRLRWATSEAVDAESMGTGMRKCWALAKDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1S184</accession>
    <name>I1S184_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG10483.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T08211</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="CEF75909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_011321164.1"/>
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    <dbReference type="AlphaFoldDB" id="I1S184"/>
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        <property type="protein sequence ID" value="CEF75909"/>
        <property type="gene ID" value="FGRRES_10483"/>
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    <dbReference type="KEGG" id="fgr:FGSG_10483"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08211"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="InParanoid" id="I1S184"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="MFS quinate transporter"/>
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        <property type="entry name" value="MFS_Sugar_Transporters"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="Sugar/inositol_transpt"/>
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        <property type="entry name" value="Sugar_transporter_CS"/>
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        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
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        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="98"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="126"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="189"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="201"/>
            <end position="221"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="293"/>
            <end position="313"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="355"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="382"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="402"/>
            <end position="422"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="31"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="533"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF75909.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF75909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="559" mass="61221" checksum="17325D942BE50BD9" modified="2012-06-13" version="1">MAGGVKKPVNIFKLKDLGEPAGVFNWRLWFAVVSFALLGAARGIDEGLISGSFNSKDFQEKINYESYSEVEQANIKANVSAMVQIGSVGGALIAFLVCDRIGRIWATRFLCTLWALGIVIFMIGGVNGNLGAIYAGRFICGLGVGQTPVVGPVYIAEIAPAAIRGLCSCMFTGAVYIGIVLAYFTNYGAHLNMSDHTHNQWLVPTSLHIMMSGIIFILMFFQSESPRYLVKQGKPEEAAKVLGRLRQQSPESDYVVRQVAEIQAALDHELEATKGVGFLGKVKELLFVPSNLYRLYMSSMVQFLSQWSGAGSITLYAPDLFKIMGIVGKQEGLLVTAVFGIVKLIAAVICALFLVDVIGRKRALLIGITLQTIAMIYVASFLTKIPQLGVDEDFELPAADKGASRGAIAMIYVSGFGWALGWNSMQYLLTAELFPLRIRALATSWAMTLHFANQYGNSRAVPNMLLPVAKGGISPKGTFWCFAAVTFVGGLWVYFSVPETSGRSLENMDELFELPWYKIGLHGNKHVEELDEARDEKKRYADEANATGIELEHQRKQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1S1J7</accession>
    <accession>A0A098DC86</accession>
    <name>I1S1J7_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG10602.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T08505</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF76055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319605.1">
        <property type="nucleotide sequence ID" value="XM_011321303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S1J7"/>
    <dbReference type="STRING" id="229533.I1S1J7"/>
    <dbReference type="EnsemblFungi" id="CEF76055">
        <property type="protein sequence ID" value="CEF76055"/>
        <property type="gene ID" value="FGRRES_10602"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10602"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08505"/>
    <dbReference type="eggNOG" id="ENOG502SUZ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_479007_0_0_1"/>
    <dbReference type="InParanoid" id="I1S1J7"/>
    <dbReference type="OrthoDB" id="5386682at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="51"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="569" mass="65199" checksum="7452D57CF125E0F2" modified="2012-06-13" version="1">MTTTIKNEQFPYNPLDPKDFPIRVLQVESGDISQSICCSLVNYADATERGWTCLSYTWGTDPPTEEIIINGVPFPVRPNVYNFLIEAQRQRLTNLWIDSICINQSDIDERNAQVRLMSQIFSDAKLVIAWLGQTSPALERAIKHLDSSFPADTVTIRAAEAQPVCCQLSPAECSSLFEACDAAVWTRRWVKQEIMLPGKVVLYCGQASISTSVFFAIMDGLVDYATLHNHTVPVPEPSSSLQADCSVEEQHEPETCFYDSHNFDQLHRHCANVLAFYSATRAKGRQKQLPMLLKMFQDSDCTDFHDHVYAFRGLMEQGLEFPVDYNMVNIDVFLETLDFLAQTSHPRLRGASAAERDLFVDLYRGFKFTTEDLEGIFGYYETSFILQVGYSFDMLRKDITVWRFVDSIDDPDEFKASPWRETTLCKPCRKVVLNDPEIDEYHTVLNQLRPEPDLSDWDVYMYGLRSWDGLGLKGLRAVYEPRWLYGPSQDTLRLLRSDIREGHHLMAMSFDTRGKDRELKQWLHEVKNHLVVMVTDRDDAAYQIQIFIMPLCKSEECLLAERPTQGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1S2K9</accession>
    <name>I1S2K9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG11005.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T20991</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325365.1">
        <property type="nucleotide sequence ID" value="XM_011327063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S2K9"/>
    <dbReference type="EnsemblFungi" id="CEF88589">
        <property type="protein sequence ID" value="CEF88589"/>
        <property type="gene ID" value="FGRRES_11005"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11005"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20991"/>
    <dbReference type="HOGENOM" id="CLU_1320990_0_0_1"/>
    <dbReference type="InParanoid" id="I1S2K9"/>
    <dbReference type="OrthoDB" id="5104305at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF88589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="243" mass="28182" checksum="4B377F9E29CAAD0C" modified="2012-06-13" version="1">MEVDNPFSVFPREVRDMMYSYSIPEIPATDATVSKTAYNTKNAPLLFLNEAISKDVQHVLYQDHAIVIPVLNPSEYELKETKFAPIVSQCSRLMKQRSNRVIIGTSRFIAASYSPLLHINIHDGTSAEDWIQKFCGFDNPEPLAKKLIDELISLRPELPNVKVIEFKFFEGFNVLVALRWREYFLELKEAWPEIEIEIDFVPAFLGWEHVEAFFQDAQDSMEEDGVFKPDRLRDLEERKYGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1S2Q0</accession>
    <accession>A0A098DVJ1</accession>
    <name>I1S2Q0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG11050.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T21113</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF85916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325309.1">
        <property type="nucleotide sequence ID" value="XM_011327007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S2Q0"/>
    <dbReference type="FunCoup" id="I1S2Q0">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1S2Q0"/>
    <dbReference type="EnsemblFungi" id="CEF85916">
        <property type="protein sequence ID" value="CEF85916"/>
        <property type="gene ID" value="FGRRES_11050"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11050"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21113"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_4_1"/>
    <dbReference type="InParanoid" id="I1S2Q0"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF85916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="332" mass="36575" checksum="AFB82FC0C6AB13DE" modified="2012-06-13" version="1">MVMTVISSVYGISSTLYSNLFVTLPYPETKHDLSDKVMIVSGSNTGLGFEASQHLLRLGLGKLIMAVRSLDKGEEARRELLKLTKREPESIEVWFLDMADYESIKAFAKRASTLPSLDVVLANAGLATSDEFTTAEDNERTITVNVISTFLLFFLLLPKLRKSSFPGKFIIPNSATHYWAPTKELVPDEKAGPIFSRLNDPVKSNMAARYYVSKLMVLYLTREIASRLDTSEKNSVIINTPNPSYCKSGLMREKEDVAPPDFLARSGEMGSRALVAGVLAGPESNGKYMNNCQIHEPACHVTNKMGTKIQGALYKELLGKLEVIAPGATKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1S3X3</accession>
    <name>I1S3X3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG11523.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T16035</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323104.1">
        <property type="nucleotide sequence ID" value="XM_011324802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S3X3"/>
    <dbReference type="STRING" id="229533.I1S3X3"/>
    <dbReference type="EnsemblFungi" id="CEF79817">
        <property type="protein sequence ID" value="CEF79817"/>
        <property type="gene ID" value="FGRRES_11523"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11523"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16035"/>
    <dbReference type="eggNOG" id="ENOG502TDGS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042941_2_0_1"/>
    <dbReference type="InParanoid" id="I1S3X3"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF79817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="260" mass="30372" checksum="69BD640DF6B14023" modified="2012-06-13" version="1">MSVSSSEDQESHHRLIDKEYSPLDQEENWKEDDKHPLRRRKSKYEKVIKYSSLACNVALSLLCFWLWSRSRSPLPPWPNTLYSPAQSAVEYETVIFNSDFPEDHSGRTAYHGASPQAEAAWTKLMDPYLVKISGKEAAGLSRPTSQISKDPDYYITSLDVYHQLHCLNDIRKMVRDYNSTEGNLERLQTMHKFHCIDSIRQSLMCNADLSTIHWYWAPSVGKNFPNATTTHICRKWSLIEEWAMNHRLDQDKYDPKTHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I1S4U2</accession>
    <name>I1S4U2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T02321</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316660.1">
        <property type="nucleotide sequence ID" value="XM_011318358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S4U2"/>
    <dbReference type="EnsemblFungi" id="CEF72962">
        <property type="protein sequence ID" value="CEF72962"/>
        <property type="gene ID" value="FGRRES_11860"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11860"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02321"/>
    <dbReference type="HOGENOM" id="CLU_2085042_0_0_1"/>
    <dbReference type="InParanoid" id="I1S4U2"/>
    <dbReference type="OrthoDB" id="4986173at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF72962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="117" mass="13072" checksum="616BC097D56C9EC6" modified="2012-06-13" version="1">MARLTDLPPEIAVWIGSYCDKATISSIVSVCVQAYNNFNVCKFEDFRARGDAGRFAYHLQTLVIVKLEMRITPCLSAARKATIVVNSSCQPNNRKKSQKLPEPPYDLLVDAADCFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I1S5N8</accession>
    <name>I1S5N8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T06185</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318520.1">
        <property type="nucleotide sequence ID" value="XM_011320218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S5N8"/>
    <dbReference type="EnsemblFungi" id="CEF74897">
        <property type="protein sequence ID" value="CEF74897"/>
        <property type="gene ID" value="FGRRES_12159"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12159"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06185"/>
    <dbReference type="HOGENOM" id="CLU_1627183_0_0_1"/>
    <dbReference type="InParanoid" id="I1S5N8"/>
    <dbReference type="OrthoDB" id="10332288at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF74897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="163" mass="18289" checksum="36C7DD589CA261D7" modified="2012-06-13" version="1">MSPLIVSSSDEDPELPLKDLRFGPLTRGSPRSVEDLNYRASHLIQTVILRMADRNVSEAVDTVRRAVFSVDASIEQGPRNTGFLVTCQFDQVCGIYLSNSNLRHLLGAAPARNPQPEPVHAPLSAHEDCRECWDKDIDIRRYRSFVQEKYPACCGGYLDCFCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I1S5S5</accession>
    <accession>A0A098D9G7</accession>
    <name>I1S5S5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T06589</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318708.1">
        <property type="nucleotide sequence ID" value="XM_011320406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S5S5"/>
    <dbReference type="EnsemblFungi" id="CEF75100">
        <property type="protein sequence ID" value="CEF75100"/>
        <property type="gene ID" value="FGRRES_12196"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12196"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06589"/>
    <dbReference type="HOGENOM" id="CLU_1517995_0_0_1"/>
    <dbReference type="InParanoid" id="I1S5S5"/>
    <dbReference type="OrthoDB" id="10461779at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF75100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="177" mass="19223" checksum="DAE4EA73A5DE9259" modified="2012-06-13" version="1">MLPGASLDNKYGTATRFMIASRGKCTYYRTFRGMAESKRGFSVSDIAGPFGEAITVNCRLGQQHLGPSQPRSSLWTVQYSTSAFPRPMAGLDWTALRCVRAEVELTGYWGGMNDDAIAASRDAEKRLHVTFGDNSSMEYAVQCRAGQSRTEQNSAVEQNVGGSSREKGPLNGVSGCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1S5Y0</accession>
    <accession>A0A098DM32</accession>
    <name>I1S5Y0_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <shortName evidence="5">AS</shortName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aryl-sulfate sulphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG04467.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T15371</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aryl sulfate + H2O = a phenol + sulfate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:33853"/>
            <dbReference type="ChEBI" id="CHEBI:140317"/>
            <dbReference type="EC" id="3.1.6.1"/>
        </reaction>
    </comment>
    <comment type="PTM">
        <text evidence="6">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321131.1">
        <property type="nucleotide sequence ID" value="XM_011322829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S5Y0"/>
    <dbReference type="STRING" id="229533.I1S5Y0"/>
    <dbReference type="EnsemblFungi" id="CEF79487">
        <property type="protein sequence ID" value="CEF79487"/>
        <property type="gene ID" value="FGRRES_12251"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12251"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15371"/>
    <dbReference type="eggNOG" id="KOG3731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_4_0_1"/>
    <dbReference type="InParanoid" id="I1S5Y0"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018958">
        <property type="term" value="P:phenol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000051">
        <property type="entry name" value="Arylsulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012083">
        <property type="entry name" value="Arylsulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF8">
        <property type="entry name" value="SD21168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000972">
        <property type="entry name" value="Arylsulf_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124839" description="Arylsulfatase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="42"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="6">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000972-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF79487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="586" mass="65503" checksum="FE89D5FD20B18BFC" modified="2012-06-13" version="1">MRSSNWINPILLASSLSAQCMGAVVSNDQKALINDTAHGKKKNIVFILTDDQDSVLDSVSYMPKLKENIIDKGASFINHFTTTAICCPARVSLWTGKQPHSTNVTDVSPPYGGYPKFVSQGLNENYLPVWLREAGYKTYYTGKLFNSHTVNNYNSPYPAGWTGTNFLLDPGTYDYLNPIYQHNQEAPVYHKGEHTSDLIAKYSHDLLKEAIDSNNPFFVAIAPIAPHSDISVDRVAGSGMTIPIPAERHSHLFEGVKVPRTENFNPDSPSGVSWIKELKQFNESSVSHLDNYYRARLQALQGVDEIVEQVTQQLEDAGLLDDTYIIYSSDNGYHLGQHRLPPGKECGFEEDIRVPLFIRGPGISSGAVEKTVTTHIDLAPTILKLAGVELRHDFDGTPIPVLDYEEGKRHEHVAVEFWGVAIAEGGFGGFDGKGLLQVHNNTYKGVRIVHEDYDLYYSAWCNNAHELYDVKTDPGQLNNLFPLDSKATADKEFLGTTVQQVINRLDALMLVLKSCKGNTCIEPWKTIHPDGKVANLKGALTGKFDSFYEEQVKVRFDRCEEGYLVDAEGPQVGYEYREGLEWHHWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1S708</accession>
    <accession>A0A098DXR2</accession>
    <name>I1S708_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T16443</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_011323295.1">
        <property type="nucleotide sequence ID" value="XM_011324993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S708"/>
    <dbReference type="EnsemblFungi" id="CEF86661">
        <property type="protein sequence ID" value="CEF86661"/>
        <property type="gene ID" value="FGRRES_12631"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12631"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16443"/>
    <dbReference type="eggNOG" id="ENOG502SNT2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_528973_0_0_1"/>
    <dbReference type="InParanoid" id="I1S708"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="PHI-base" id="PHI:1844"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
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            <begin position="165"/>
            <end position="194"/>
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    </feature>
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        <location>
            <begin position="126"/>
            <end position="163"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF86661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="515" mass="56207" checksum="3DC6EA277B2AF81C" modified="2012-06-13" version="1">MNMIMSSLQTLAGKVAVVSGTSYADVVSQKCGEPHSHGDRIYPCRHRVRRLKLGQLLYQFFPSAYNCRLAYTLRPSITSSMAASPDVCASSLRVRLGTKTWWHCSSGYIYMERPRTQHIPALSASETHHNHSNTMKRQAPCEPSDESQQARKRGPSSRPPRASQACRSCAASKVRCDDLEICRRCLKRGVPCIRPTPVGQGYRSAMGEAPCVLSNLSTRTSVDRDGSCILASTIQELAETAPPAIAPINSVARDENRGELTNASFVSPNSPMSLGHPGHSQCSDTQTMDNLGDILLTDTTEWFKNLSFHAEFDTSFLLPLPFIDLSGYPDEILIENPTDLTTMSSESMLPQEKTIFDEAVIAHSSTLGSWKPTHEDYLGAARASLYVPLDEQVLLEEGLGHLNSTVIGGCLSSARRDEIIVAMIDGTQTAQTLLAVRMFPSVEILDRFLKIFLTSQETSALAFVHIPTFDPSTCSLSLLMACIVAGATLSPIASAPSVSHKMPIIRVVVDFERGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1S7G0</accession>
    <accession>A0A098DXX3</accession>
    <name>I1S7G0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T18487</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324247.1">
        <property type="nucleotide sequence ID" value="XM_011325945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S7G0"/>
    <dbReference type="EnsemblFungi" id="CEF86700">
        <property type="protein sequence ID" value="CEF86700"/>
        <property type="gene ID" value="FGRRES_12783"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12783"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18487"/>
    <dbReference type="eggNOG" id="ENOG502RMIY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1652246_0_0_1"/>
    <dbReference type="InParanoid" id="I1S7G0"/>
    <dbReference type="OrthoDB" id="5096019at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF86700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="159" mass="18061" checksum="5361613BDA47B6FA" modified="2012-06-13" version="1">MSSKEEKSTNGASRRQSQASMGNFGNESLDRSEETVLTRRQKRQLRRETLRLQAEVAPFMGMDLDDDEEIKVEDETKVEDETKVEEKTEVEKKEEEPAKNVIGTPLDTVPEVDETLVDDRAVLSGLRPNAFKTPPSGESEFPGRENWWTRGIMGMSIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I1S9R3</accession>
    <name>I1S9R3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T27011</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328256.1">
        <property type="nucleotide sequence ID" value="XM_011329954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S9R3"/>
    <dbReference type="EnsemblFungi" id="CEF83247">
        <property type="protein sequence ID" value="CEF83247"/>
        <property type="gene ID" value="FGRRES_13594"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13594"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27011"/>
    <dbReference type="HOGENOM" id="CLU_1461443_0_0_1"/>
    <dbReference type="InParanoid" id="I1S9R3"/>
    <dbReference type="OrthoDB" id="5090193at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF83247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="185" mass="20143" checksum="7F3DFE49C9D18210" modified="2012-06-13" version="1">MGKSKAVPPLCSPDAAILSEAVPAFCSPGAAILSEDDLPLKELRSFDDLIKALNPNLEDSRRPVPAKEPTKPPKPTLSDIGVEAGVWKDDRNAEAIDSIASRGHGSKSAKRKAEDDGRSVRRAKAKEPGKKAYCTVSVTKKSGINIKWKDKTSSFAGPDKVQLIGYTTFSRVKFKAIEKHNRFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>V6R5D2</accession>
    <accession>A0A098D4R4</accession>
    <name>V6R5D2_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG01759.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T04275</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317595.1">
        <property type="nucleotide sequence ID" value="XM_011319293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6R5D2"/>
    <dbReference type="STRING" id="229533.V6R5D2"/>
    <dbReference type="EnsemblFungi" id="CEF73944">
        <property type="protein sequence ID" value="CEF73944"/>
        <property type="gene ID" value="FGRRES_01759"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01759"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04275"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_1_1"/>
    <dbReference type="InParanoid" id="V6R5D2"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF73944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="494" mass="53000" checksum="7BD6406E187B6EEC" modified="2014-02-19" version="1">MTSSVTLQGAQGRQITVQTGLFIDNEFVPASNNATLDVENPNTATIIAQVSAAQASDVDRAVRSSQKAFATWGRSDPGTRRTLLLKLADLVEAHGPELASLEAIEGGLLYRDSLGLHVTQSVDNLRYFAGWADKLDGVSLPIPSGVAYTRREPIGVCAAIVPWNSLMILFWKLAPAIAAGNTIVIKTAELTPLWAQKAAELIKEAGFPPGVINIICGLGREAGQALAEHPVVRKIAFTGSSVTGRQIMQSAARSNLKKVSLELGGKGPSIVFADADWENALLWTTMGITASNGQICAAGSRIYVQDTIYEKFIQEFSRRSRDAVHGDPLLDETTKGAVASKAQLDKILSYVGKAKQTKARLLHGGQPLPGKGHFMANTAFVDVDQDDTIMREEIFGPFASIAPFSTEDEVIRKANDSDLGLNSAVFTNDVSRAFRISEAIETGTVTVNCWAMLNANTPFGGVKESGFGRDSGQEALDNWTVTKTVKFNILPPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>V6RDP1</accession>
    <name>V6RDP1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG03247.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T12417</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322504.1">
        <property type="nucleotide sequence ID" value="XM_011324202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6RDP1"/>
    <dbReference type="FunCoup" id="V6RDP1">
        <property type="interactions" value="361"/>
    </dbReference>
    <dbReference type="STRING" id="229533.V6RDP1"/>
    <dbReference type="EnsemblFungi" id="CEF78011">
        <property type="protein sequence ID" value="CEF78011"/>
        <property type="gene ID" value="FGRRES_03247"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03247"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12417"/>
    <dbReference type="eggNOG" id="KOG2517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_2_2_1"/>
    <dbReference type="InParanoid" id="V6RDP1"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000086">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000085">
        <property type="entry name" value="Glycerol kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF75">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="11">
        <location>
            <begin position="13"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="12">
        <location>
            <begin position="277"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF78011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="516" mass="56310" checksum="A70BD60B30133910" modified="2014-02-19" version="1">MPLLNGKANTAFIGAIDQGTTSSRFLIFDPSGDVVATHQIEFKQYYPHPGWHEHDPEELISSVEQCIDGAVETFESQGHSREQIKAVGITNQRETTVVWDKTTGKALHNAIVWTDTRSKDLVRRLKRRLGSSELIGRCGIPLSTYPSVSKLLWLLDNIPEVKDAYERGVLAFGTVDTWLTYKLNGATDRDVYVSDPSNASRTMFMNLETLKYDEDILDWFRIDDSKITLPRIVRSSDNKAYGSLAGTSLKGVKITGCLGDQSAALVGQKAFTPGLAKNTYGTGCFLLYNVGTKPVISSHGLLTTVAFDFGEGNTMYALEGSIAVAGSSVKFLVDNFGFIESSAKLSALAETVEDNGGCTFVTAFSGLFAPYWIDDARGTIFGITSYTQRGHIARATLEATCFQTKAILDSMEKDSGHALTELAVDGGMCNSDLIMQTQSDLIGIPVNRPGMRETTALGAAIAAGFAVGIWKSFDDLKEVNTQGRTIFKPQIAEEEATKRFGRWTKAVEMSKGWANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D154</accession>
    <accession>A0A0E0RN23</accession>
    <name>A0A098D154_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG00673.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T01695</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D154"/>
    <dbReference type="EnsemblFungi" id="CEF72648">
        <property type="protein sequence ID" value="CEF72648"/>
        <property type="gene ID" value="FGRRES_15768_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01695"/>
    <dbReference type="eggNOG" id="ENOG502R6WE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098D154"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF72648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="614" mass="67818" checksum="FE70A7A8928001CF" modified="2015-01-07" version="1">MQTTDLPTWFWLPLKGDCEWDSPFNMGNCFDEQYHNVFFILIKALIYLTRFTTFPFVLFFAGMHGEFLATLPMAILSTTTIIPMVLLRLIWAEDYHTHGGLGNPMVEYSVKTWAILSMPNIVSWTPSAAFAVSHSVRIVRETFVSLRIQADSSFDAETLFPTPFAGRDWDLDLSTSGAEAWIRMLVQEDQEERHARREEEKRLAAEQKRLEQAPLLMQKLEDDTNIAIWKAISKRRPQPIIRRQSALTHRQETEMLAEERGLTKKQLLAQRYVVVPVDQSTQSDPSDFADDRAMKTPSDLAESPVLTQVEPSEPAPTGSSPSSSLSPPSHETTPKKPASSTNDAAAATATPGRETPPVREPAPSAVSPRQEVVEAITTLPSPPSPGVVGVVSSSHVVDEPIFPSEEELPPQAIVPFTEPVGLEPLRQLPSPEQATGSVASFAQEAPGIPKIPEELLFAAANGSEDGWEESLHQGLFQPAPCISPTWGPTELDAAIDNLLNSGDEVGEQVWDEMAIDDCQVEDVEMEEQGEGEIEVLTPSQAVDSEMEMVGMTEEEQERMVQEASWAALAALLDEDKDEFYDEPSQMVIDHAAPAQTLSVPQLPLPQFNRPPPPP</sequence>
</entry>
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        <submittedName>
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        <name evidence="5" type="ORF">FGRAMPH1_01T00579</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D2D6"/>
    <dbReference type="EnsemblFungi" id="CEF72091">
        <property type="protein sequence ID" value="CEF72091"/>
        <property type="gene ID" value="FGRRES_15708_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00579"/>
    <dbReference type="InParanoid" id="A0A098D2D6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cellular hyperosmotic response"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:phosphorelay signal transduction system"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CheY-like_superfamily"/>
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        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
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    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR45339:SF1">
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        <location>
            <begin position="107"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="160"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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        </source>
    </evidence>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="19">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="19">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <text evidence="13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the tubulin family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 14" id="KW-0342">GTP-binding</keyword>
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        <location>
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    <sequence length="450" mass="50383" checksum="4FCB2DD65BF82464" modified="2015-01-07" version="1">MNTDIGSQFWQQLCQEHGISQDGNLEDFATEGGDRKDVFYYQSDDTRYIPRAILIDLEPRVINGIQTGPYKNIYNPENFYVGKDGVGAANNWGDGYQSGEAVYEDIMEMIDREADGSDSLEGFMMLHSIAGGTGSGLGSFLLERLNDRFPKKIIQTYSVFPDTTNAGDVVVHPYNSILSMRRLVQNADSVVVLDNGALSHIAADRLHVQEPSFQQTNQLVATVMSASTTTLRYPGYMHNDLVSILASLIPTPRCHFLMTAYTPFTGDQVEQAKTVRKTTVLDVMRRLLQPKNRMVSTVPGKKSCYISILNVIQGEVDPTDVHKSLLRIRERRLATFIPWGPASIQVALTKRSPYIPMSHRVSGLMLANHTSIATLFKRILRQYDGMRKRNAFMEGYKKTAPFSENLNEFDEARQVVADLIGEYEAAEDADYLNPDAGEKPTSIETDRRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DBU7</accession>
    <accession>A0A0E0RYS3</accession>
    <name>A0A098DBU7_GIBZE</name>
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            <fullName evidence="4">Chromosome 2, complete genome</fullName>
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        <name evidence="5" type="primary">FG08132.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T09191</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DBU7"/>
    <dbReference type="EnsemblFungi" id="CEF76398">
        <property type="protein sequence ID" value="CEF76398"/>
        <property type="gene ID" value="FGRRES_13435_6_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09191"/>
    <dbReference type="InParanoid" id="A0A098DBU7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057230">
        <property type="entry name" value="DUF7908"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25485">
        <property type="entry name" value="DUF7908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010018636" evidence="2">
        <location>
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            <end position="683"/>
        </location>
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        <location>
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        </location>
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        </location>
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        <location>
            <begin position="361"/>
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    </feature>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF76398.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DDT9"/>
    <dbReference type="EnsemblFungi" id="CEF76617">
        <property type="protein sequence ID" value="CEF76617"/>
        <property type="gene ID" value="FGRRES_15475"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09629"/>
    <dbReference type="InParanoid" id="A0A098DDT9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF76617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="56" mass="6010" checksum="4F68688F815AFD95" modified="2015-01-07" version="1">MDGLKAIPTLWEIVNVVAALRLAPGQSQAVARMCLSSSQSVGPRVTLKAQWRISFG</sequence>
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<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DEK2</accession>
    <accession>A0A0E0S037</accession>
    <name>A0A098DEK2_GIBZE</name>
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        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DEK2"/>
    <dbReference type="EnsemblFungi" id="CEF76862">
        <property type="protein sequence ID" value="CEF76862"/>
        <property type="gene ID" value="FGRRES_15491"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10117"/>
    <dbReference type="InParanoid" id="A0A098DEK2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF76862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="65" mass="7122" checksum="8470DAB2EF23B135" modified="2015-01-07" version="1">MALASTVIHNPAAVLKEESVKNKMIYLAIPVCKRMDTDALVAILTGNEHWIDFSFVSCCLDVGVE</sequence>
</entry>
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    <accession>A0A098DJU2</accession>
    <accession>A0A0E0S5F0</accession>
    <name>A0A098DJU2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG03845.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T13845</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DJU2"/>
    <dbReference type="STRING" id="229533.A0A098DJU2"/>
    <dbReference type="EnsemblFungi" id="CEF78725">
        <property type="protein sequence ID" value="CEF78725"/>
        <property type="gene ID" value="FGRRES_16191"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13845"/>
    <dbReference type="eggNOG" id="ENOG502RYDN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DJU2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF78725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="285" mass="32747" checksum="F0EACBEB8753F794" modified="2015-01-07" version="1">MASEQQLKTTPSNDQDDGMKIIHAGLFRTATKSMTEAYRILGYKAHHALDDVWAVPWSGIEQAAEATFPHLAQLPDYTYKSTDGSAAPRPPFTRDDWQSLWGEYDVATDIASAFVPELIKAYPDAKVVVVQRQYESWWPSFKSECLDTLYRVTALQQFVVRYIIRFRAGYAMKKIHAGFFGADEYSLESVEVRARDVYEEYYRKVREAVPLESGRRLDYNIGDGWEPLCEFLGKDVPDVPFPRVNDRADHSARVKENHRKMTIDALKLISPIIAVLVGVTFYYWR</sequence>
</entry>
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    <accession>A0A098DKD1</accession>
    <accession>A0A0E0S5Y2</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
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        <name evidence="2" type="ORF">FGRAMPH1_01T14209</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DKD1"/>
    <dbReference type="EnsemblFungi" id="CEF78907">
        <property type="protein sequence ID" value="CEF78907"/>
        <property type="gene ID" value="FGRRES_20189"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14209"/>
    <dbReference type="InParanoid" id="A0A098DKD1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF78907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="72" mass="8170" checksum="02CD3935BD58FDE2" modified="2015-01-07" version="1">MKIAKSQRQDKANKHTTPDANAATAATQTEALSNTDWEYGTLQSNPAKNKGPPNWWFICVLQQQQQQQQQQQ</sequence>
</entry>
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    <accession>A0A098DML6</accession>
    <accession>A0A0E0S9I8</accession>
    <name>A0A098DML6_GIBZE</name>
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        <submittedName>
            <fullName evidence="9">Chromosome 4, complete genome</fullName>
        </submittedName>
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        <name evidence="10" type="primary">FG07740.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T25535</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DML6"/>
    <dbReference type="EnsemblFungi" id="CEF83101">
        <property type="protein sequence ID" value="CEF83101"/>
        <property type="gene ID" value="FGRRES_13210_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25535"/>
    <dbReference type="eggNOG" id="ENOG502QU6M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DML6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="191"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="331"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="425"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="450"/>
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    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="262"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF83101.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF83101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="462" mass="49774" checksum="0314D0969DBDA59E" modified="2015-01-07" version="1">MSSETAVVAHPRSAHISNHEFSNYSPPGDSQPGPEMQQQSNPMIPKFQIAAAGFSFFCAGVDGATLGPLLPYIIQSFTINEGEVAIIYACIFAGWVIAAVTNLFLATKLSFSSLLTLGATLQLVAQCLRPWASQPVFFISFAVQAVGMGYQDTHANAWASGLPNAHRCLGFIHAMFALGCLVGPLVATAIATATGSGHSTTNGIEAWRMGYFQLIGIHGLNLIGMLLAFGNPLRRWKTLEVAIPQASATGTADSDVIQQRNKDALRDIGQLLKMKNFWLIGGFYLFNCGAWSAAGGWVVEYLVAHRDGVLEKVGYVPTGFWAGLFLGRLLLAEPTHRFGEQRSIMCLSAVCLIFHLLFWLVPNLVASAVAFSFMGFFFGPFFATGMSVASRMFPRKIQSMALGLVFVLAQAGAAIFPSVTGLIATRAGVQVLQPVILGLIIGGAVCWWFIPRIPERMDEPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DP90</accession>
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        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
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        <name evidence="5" type="primary">FG11558.1</name>
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        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DP90"/>
    <dbReference type="STRING" id="229533.A0A098DP90"/>
    <dbReference type="EnsemblFungi" id="CEF79776">
        <property type="protein sequence ID" value="CEF79776"/>
        <property type="gene ID" value="FGRRES_11558_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15955"/>
    <dbReference type="eggNOG" id="ENOG502SVCF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DP90"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF79776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="399" mass="43605" checksum="34561006078DAD1C" modified="2015-01-07" version="1">MPPEPSSRSESRRTHKKSRTGCDTCKKRRIKCDEVHPRCAKCTFGNRTCSYAAAPGPGQGQAGLNTNVAGSSSNSPAGTPLSPALLAAAAEARSTVAAPGRYDAIHMSLFHYAIINMTTFMGVGGDSSRVVESALDSTHVAPYLLDQLLALSALYQSTTAQASQNLYLRYATELQTRALAQFLETRGNISGTNFIPAFLFTSFLGIHVLYNTFRDHQDNLGEFVSAFVDYARVHQGIRAVTANYWPQILASNLAPLLGIVEIGNRIDHLEPGTETIELRKLLESLSDSSRMPVTASINALQRMQWVLDLANHNAQSSSNKIQAALAWPVIIPEDYIDALYLRHPEALAVLAFFLAFVYENRSYWVFQPCAGSLIEAVANHLGPFWKEGLSWPLSKLAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2024-01-24" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DTM3</accession>
    <accession>A0A0E0SE39</accession>
    <name>A0A098DTM3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T28229</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DTM3"/>
    <dbReference type="EnsemblFungi" id="CEF84702">
        <property type="protein sequence ID" value="CEF84702"/>
        <property type="gene ID" value="FGRRES_20407"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G28229"/>
    <dbReference type="InParanoid" id="A0A098DTM3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010018731" evidence="1">
        <location>
            <begin position="23"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF84702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="316" mass="33353" checksum="01369F18903C2D94" modified="2015-01-07" version="1">MATQLLMLDILCLLDIFAVAHCSTCYVVALGFVTVEEKPLLSIPPHSSGKNLALNIGTLLRQILGAHGVVNTGNALLNNGTLIQISSNKVSGGTDNLDTTLVSLVVRLGSLERRQETVVDVDDASRHGLAQCRRENLHVTSQDNKFNAVLLAELKNLSLLLSLGILCHGEMVELNSVALGEGGVLGVVGNNNGNLHAKLASLHAEEKIVETVTNLGDHDEDSGLAGNGTNIVFHLVLGGELVKSFSEVLGRFGLGRTKVNSHKETLRDGIGELLEVENVVLVVGKDTSHGINNAGLVGARQSEDVIVGHVEGLLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DV49</accession>
    <accession>A0A0E0SE60</accession>
    <name>A0A098DV49_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG09091.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T27949</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DV49"/>
    <dbReference type="EnsemblFungi" id="CEF84723">
        <property type="protein sequence ID" value="CEF84723"/>
        <property type="gene ID" value="FGRRES_09091_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27949"/>
    <dbReference type="eggNOG" id="ENOG502SJVS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DV49"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42029">
        <property type="entry name" value="AN04G07800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42029:SF3">
        <property type="entry name" value="AN04G07800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF84723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="317" mass="36673" checksum="7A77273023A8E61A" modified="2015-01-07" version="1">MSEHGEWPSSPEKIALEAWSQGCMIGALIIMIGITVVNMRRGVVLHKLILIELLLAMPNGFFMFFKPPVWGWYLSSTVILLIISWNLHNVISWLKNKPFLSKRYNAIYIGTIVLVQPYWVLEIYANFTYFNPPYTRFFSSSRPLEALCRDPWWIFTALNLFWNIKYRYEFKYLELIRISPRFAVLLLSMTLSIIFIIIDLFAVTSVLHIGYINPFWKFAFIFKCFTDTIVLDDFKTALDKLSRYKMEQNYPLPFSRPGSQTNIEPQRSSIADFAVICPVESSALVTVEHLERAHTDSISSPPRAVRASQTGLGGRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2024-01-24" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DVU7</accession>
    <accession>A0A0E0SEX0</accession>
    <name>A0A098DVU7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG07732.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T25517</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DVU7"/>
    <dbReference type="EnsemblFungi" id="CEF84983">
        <property type="protein sequence ID" value="CEF84983"/>
        <property type="gene ID" value="FGRRES_16886"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25517"/>
    <dbReference type="eggNOG" id="KOG1802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DVU7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF84983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="745" mass="84173" checksum="A129165BFF615804" modified="2015-01-07" version="1">MSQQDMDEPPALGQKEPHTASYLQNCVVFMCNSDQVLTASKSFAGPTKLTSRLIVMISRDVNPVFLFEISFPLGEGQPDNENFGFGVKHKLNYGINKVEANDRQTIEVRFPREKTQAKCEVAPASIVDRRFRVKDKDKVCILTVSVTAPVTTVGYGSPFRSADTEVNSWVNDNEPIGQGGNLHTFLQQQSFTFLVAKGAVDFEKRLDLDRLPPPFRYPYESTLRGYQFPPRYSHPNDLIHVTAVVQGTSQDIMWLNERREEIAATKFSGYFVTQPDSTIDKATSLYLVIARTPEFKHKQAWGHLQKGQLVKVALFDSPSDEKEQETWSVFHNHAPVQQPLIPSRNAKIVSSSEDVPKLSNHPIEKHELVLIVQAKMKPDAPFDIKFFCSREAAQYKGFYQWMSKPAPRDIVEAIEAMMLQDAPATLRPLPVVNFREGVDKEYADEIVDEALSGDRKRFRAYLEHRPLGLGIATSASLGPTFCSAPTNVDVDNFASRIDNRSAMIAARYNYCKHAGGAPRFHRRFVVRAYDMTHESAAFRRLLQDPNQGDNAAPNSFFDPPSNWRLHLSRVYWLSVLLRSPIVRSLHQDDAPVLHQLQQGIDKNLDIADLRALVTGAIDWETFIGSKEYDIAMTTAGEYLDDIACRAEILCAKGFPIDEASNMKRPDLYCVWGNTLSPLFVFGDPKQLRPTVMMPTERWPNSKKRPGEFINRFAWDARISAPEYLQASGIPTYRYHGDLDTTKASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DWX9</accession>
    <accession>A0A0E0SIU3</accession>
    <name>A0A098DWX9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG04716.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T16149</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DWX9"/>
    <dbReference type="STRING" id="229533.A0A098DWX9"/>
    <dbReference type="EnsemblFungi" id="CEF86356">
        <property type="protein sequence ID" value="CEF86356"/>
        <property type="gene ID" value="FGRRES_16405"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16149"/>
    <dbReference type="eggNOG" id="ENOG502QTMD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DWX9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001716">
        <property type="term" value="F:L-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF342">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="106"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF86356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="785" mass="88722" checksum="C8315A4D1A184BAD" modified="2015-01-07" version="1">MASEQPFIEVHQKTQSYKHMWARDVARATMDYDLKGVVDLVNGSKANVTIPPKINIGQLREVTEELTGPGYIPKAKGQIDVGIVGAGVAGLFAALLFDWLNDHPNLKGKGLKINYDILEAAGAERLGGRLYTHHFSDEEHDYYDVGAMRFPNNSIMKRTFQLFQYIGLTQESKPGLIPYYLKDVLNKCPSYFNDVSHEGNVWADDKHPNDPYKVNGGLPPNGKIPEDLLKTDPNKLVSEALGVFMKEVKEKFKLAIAEKNGELDEGSKKDQEEVTKNDGPIRSRRAQELWELLMKADHMSVRQFLGSGQPHELRKKDTPPPQDKSQPFPLGPGYNFNTIEWLETMTYGTGWYNQSLTECVLEELDFHTDDMDNNPATEDIQYWWCVDGGAQEIAKRMAAKANKRIEYNTCVRSIDAQVPLRAAGKYTGMKLHTIRTDPKTNKVESKDREYFAVLNSTTLGALQRMELRDAGLSWGTKQAIRALGYGASAKVGMKFRTAWWQKEPFGIAQGGVSRTDLPLRVCVYPSYNILKNEGEDKWDPEKPAVLLCSYTWGQDAQRLGSLCSNNTTHDDKELKRLIIHDLARLHAREEFPFEELVKHLEEQYIDHHGYDWYRDEHMSGAFAYFGPGQFSNMWQEIIKPNAFGQLYLVGEAASSHHAWIVGALESVIRAVYVMFQGLQNGNPSFEPYNIVLELLKQAPTDRDEKYEFEDIGEPLKRGGGMPTGLPFHPLPEEMPTTQLRTKKGASLTDNPKEEANDRPVDMTYGAALAVLSLIESFFELVVDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RUL1</accession>
    <name>A0A0E0RUL1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component SEC15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG02609.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T06263</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the SEC15 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RUL1"/>
    <dbReference type="FunCoup" id="A0A0E0RUL1">
        <property type="interactions" value="551"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A0E0RUL1"/>
    <dbReference type="EnsemblFungi" id="CEF74936">
        <property type="protein sequence ID" value="CEF74936"/>
        <property type="gene ID" value="FGRRES_16023"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06263"/>
    <dbReference type="eggNOG" id="KOG2176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0RUL1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.30:FF:000004">
        <property type="entry name" value="Exocyst complex component SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.670:FF:000004">
        <property type="entry name" value="Exocyst complex component SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="7">
        <location>
            <begin position="51"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="6">
        <location>
            <begin position="407"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF74936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="775" mass="88015" checksum="512B0659D41EEB37" modified="2016-04-13" version="1">MPRRPPAVDDYASAVPHVILASSDAEFLDQLIPVLKDATHSNRTPLLTQCLSRYYEDREAEIERIGLTRHEEFLDSINHLQTVRAETVTLTQEILSLNESIATSTKKLATQKEALVNTSAVRQNIADATSALNDSLTILRAVNNAHDLVRRKKYYAALKSLDDLQNEHLVPIIQNRYSTQHRLADVIQKSIPASQKAISEAVMTDLNTWLFRIRETSQFLGEVAFYHTEMRRTRQKKRVEDDPFLANFKLNSAIELVSDENEDFDVLNNEELQVDFYPLLEALHIHEALGQLDKFRSEYGATRRQQKDLLLPSSIGLLAEDEQSLSSLLEGIAGFAIIEKATMQRVPHLRSASDVEELWDSMCTAVINLTSKGLGDIEDAEALIKIKTIIALFIQTMEGWGYSVTTLDNFLLKLFDKYAELLKKRFSEDFHEIVSTDDYMPMAINNPEEYEKVVNVSWFSQEKPTDQITYPCVLPFSQMYPLCCIDIRNFLNQFYFFSDDHFQHPTVIDETLRKSLDELLTEKVCKSLVERLSSQYLGQIVQILINLEHFEIACRELEQLLIRARSSTSAGGPVTLKATDSFRDNKKTAEKRIFELVNSKIDDLIDTAEYEWTASTVEKEPSNYMQTLTRYLSNIMNSTLLGLPREIKELIYFDALSHTAEKILALPLSNDVKHINPNGVAALAQDVDYLVQFVSSLENGQMLRENLDELSQTISLLQTDNQDEFFDISTRNKKYGRVNALNGPMLLEKLTPVAASPARSAPLAGFSSRFGIGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RWD7</accession>
    <name>A0A0E0RWD7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG10195.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T07517</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RWD7"/>
    <dbReference type="STRING" id="229533.A0A0E0RWD7"/>
    <dbReference type="EnsemblFungi" id="CEF75562">
        <property type="protein sequence ID" value="CEF75562"/>
        <property type="gene ID" value="FGRRES_15041"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07517"/>
    <dbReference type="InParanoid" id="A0A0E0RWD7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019034">
        <property type="entry name" value="UPF0390"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09495">
        <property type="entry name" value="DUF2462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF75562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="92" mass="10052" checksum="F27C4C37D2747749" modified="2016-04-13" version="1">MAQGTVKNLGRATPAKAVHSKRQASKVHKPKQTKKSIDKVHRKFTSGMTAQTEKLLGERAGHLELLGQKKKKGEKKSTDKRATTKGGSKKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RWE7</accession>
    <name>A0A0E0RWE7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG10204.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T07537</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblFungi" id="CEF75572">
        <property type="protein sequence ID" value="CEF75572"/>
        <property type="gene ID" value="FGRRES_17328"/>
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        <property type="entry name" value="ISOFLAVONE REDUCTASE"/>
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    </evidence>
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    </evidence>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
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    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="229533.A0A0E0S409"/>
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        <property type="gene ID" value="FGRRES_16270"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF78234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="425" mass="46420" checksum="EEFAA510C71B9A43" modified="2016-04-13" version="1">MSSSVKSTFVGAIQASASVLLTIFYGVFAGQTKLLSVETGRQISKICIKMFLPALLIVNLGTQIEASNASLYLTILVWALVYNLASIAVGYALTKCFSMPKWFTPAITFNNTTSYPLLLIQSLGSAGVLSALAKSEDDTSDDIIERAKSFFLVCSVVSNMLTFGLGGKLLGVSDEDPVESMDEDLRDRAGQNDHPPTDSQEPDERTSLLPGRLPRYVKKASRHTAQAQHAVWDKLHPRVQRALAYVTQFISPPTVGAIIGVVLGFVPPLKKAFFNDSEDGGVFNAWLTVSLKNIGELFVTLQVIVVGIKLAHSLRRMRQGSDSGNLHWLPLSMVVLIRFIIWPVLSILFIRMLFTQTDVLGEDRVLWFTMMLMPAGPPAMKLVAMAEVDDADENDKMSIARVLMTCYAISPLLSIAVVASLKACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YIP1</accession>
    <name>A0A1C3YIP1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FGRAMPH1_01T05897</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YIP1"/>
    <dbReference type="ESTHER" id="gibze-q4ik00">
        <property type="family name" value="AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05897"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YIP1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SCB64427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="530" mass="59906" checksum="9E551A4BCB68F872" modified="2016-11-02" version="1">MAIYFSFFFAWMMTLGSLLVSVFTRIICTLLVLVASIAIYRLYFHPLAHVPGPRFAAISSVWHAYNARNGRMAYLGKTLHRRYGPVVRVGPNEVWFNTKEAFHAIYSSGSGYEKSDFYLATALNKPYIDWHLNPEFPDTLDLLSERDVRRYRIQRRLIGPVYQTSSLIQYEAAVDEVLARTVAKLKSLKGAQVELNEWMHIIAVECLGAIVLSWSPSMLKNGTDNGSGTHAYHGWRRKSVFGLFPLAAKLEFLSKSTGRLFSTIWGVNFQPPKDFRPFFPDVGKRASRRINAATKSKHHKDDRQDLLKDLISLHKSKPEFTVNYLRKMVITNFGAGHETMASTLTSIIAMLGSNNDIQEQVSREILETHNPADYSTATRLPKTQCLIKETKRLYPVISMSLPRTVPAGGLHLHNNYFPPNTTVGCNPVALHRNPEIFGSDCNEFKPDRWLTADSDAARNMERVSLSWGGGARTCPGRHLAELVVFKVIPALIKEFSIEAIVPPEDENRSYFLSMLTSVKVRFVERTTADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YIZ9</accession>
    <name>A0A1C3YIZ9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T07061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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    <reference evidence="13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
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    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
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        <property type="protein sequence ID" value="SCB64518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06863"/>
    <dbReference type="eggNOG" id="KOG3126">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A1C3YJ05"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Voltage-dependent anion-selective channel"/>
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    </dbReference>
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        <property type="entry name" value="Porin"/>
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    </dbReference>
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        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
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    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
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    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SCB64518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="352" mass="37132" checksum="A70E3B2951EAD345" modified="2016-11-02" version="1">MSVPAFSDIAKPANDLLNKDFYHLSATTFEFKDTAPNGVAFKVTGKSSHEKATSAAIEGKYTDKPTGTTSPSSSSTSLSQSPSPSPPPVSNPRRKQNLPSLSVSRILGPKSGWPIGFATFVRPGFAQLLMFYSRTGLTLTQTWNTANALDTKIEVADSLAKGLKLEGLFNFLPATAAKGAKFNLHFKQPGFHGRAFFDLLKGPVANVDAVVGHEGFLAGASAGYDANKAALTAYSAAVGYAAPQYSAAITASDNLSVFAASYYHKVNSQVEAGAKATWNSKTGNAVGLEVASKYRIDPVSFTKVKINDRGIAALAYNVLLREGVTLGLGGSFDTQKLDQATHKLGASFTFEG</sequence>
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<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="4">uridine/cytidine kinase</fullName>
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        <name evidence="11" type="ORF">FGRAMPH1_01T05943</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Sordariomycetes</taxon>
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    <reference evidence="12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="4"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJ26"/>
    <dbReference type="FunCoup" id="A0A1C3YJ26">
        <property type="interactions" value="827"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YJ26"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05943"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJ26"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000339">
        <property type="entry name" value="Uridine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000010">
        <property type="entry name" value="Uridine-cytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="9">
        <location>
            <begin position="34"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="260"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SCB64431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="455" mass="51318" checksum="271300786BD86C2C" modified="2016-11-02" version="1">MSASAIPEMNGGLESHVTVQKRAYYSPPWADVSIIGVAGSSGSGKSTLSQAIVKKLNLPWDSFYKTLTPEQSKMAFANEHDFDSPDAIDFDVLVEKLRDLKAGRRAEIPVYSFAKHARLDHTTSIYSPHVLVLEGIFALYDPRVIELLDMGIYCEADADTCLSRRLVRDVRERGRDIEGIIKQWFGFVKPNFEKFVEPQRKVADLIVPRGIENRVALDMMVQFVEKKLFEKSRHHREALSRLEAASKDSALSDRVVVLNDTRQLKFMNTILQDIDTDPEDFIFYFDRLASLIIEQALNNAHFEAKKIITPQGYEYKGLVPTGEVCAVIVLRGGSAFEPALRKTIPDCRTGRLLIQSDYSTGEPELHYLRLPDDIASQQSVLLLDTQMATGGAALMAVQVLVDHGVQQDRIVLATYSAGKVGLHRLTSVFPEITVVVCNMLDYQQERWVEKRYFRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJ53</accession>
    <name>A0A1C3YJ53_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T05449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJ53"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05449"/>
    <dbReference type="eggNOG" id="ENOG502QRAQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJ53"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="1">
        <location>
            <begin position="178"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB64396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="295" mass="33212" checksum="BF06FFB54F857E9E" modified="2016-11-02" version="1">MNDSVALSTFNSLMEKNLVFFDERQQIVQHNDKGLKFQFILTSALARKPTFQVNPDEGEEQVDNVIDQVRDGSDINTTGYEMCDISKTHFLAANKFCFARPHLMLLTSDGNKRQYEPLDQNDWQALNNVLTDLGDDYVAFFNCGQDGGCSRLHKHMQLIPKPKDSFAAFLDTEDGVEPDVPFQWFYHRFESPPLDSNQLLDVYGRLLQKATEAGKGQSEHVDSLLAEAAIPHNMLVTNQWMIVLPRRRAAVNKKAGANSIGMMGVIAVATQEEIDNWIRIGPVEALKELGVPKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YK70</accession>
    <name>A0A1C3YK70_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T20375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YK70"/>
    <dbReference type="STRING" id="229533.A0A1C3YK70"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20375"/>
    <dbReference type="eggNOG" id="ENOG502TDM7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YK70"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="311" mass="36002" checksum="AB155DC426633998" modified="2016-11-02" version="1">MFRRRRRSDTPPPTPAEQFRRDAKFTLPAATQGQSRLLTLPAEIQRIIFTELLGDKFVHVHLRHKDDKYEREGAPSKVSRWIHCVCLRERNAIPHYHDEKNHKWCFLSINILRTCQLAYLQSLPVLYQTNTLAFRCAKDATLFESLFVHFSSLIQSVDLYCTDCGCFGENLCRRQCHSDRRWRMNTCKFDSYYQLFLNSTSSSAKIRTLRLYFENDDSSSFHHRIKALVFSSIQPDAQIQIFVPGEFDKRADETIKLEAPPTKRDRVTVITHAKDLISGCRREMSDEEAEQHADGNVGRAVDSNPGDEGLA</sequence>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKD2"/>
    <dbReference type="STRING" id="229533.A0A1C3YKD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20947"/>
    <dbReference type="InParanoid" id="A0A1C3YKD2"/>
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        <property type="component" value="Chromosome 3"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008687559" evidence="1">
        <location>
            <begin position="20"/>
            <end position="376"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="376" mass="40545" checksum="708C37210CF319A4" modified="2016-11-02" version="1">MVALKFCLLFLALGAQTLAGPDKPESTCSTILGSKTVKNVPTSTGTVKRNITIVKKVIRKVNVIVVPPAKTTTTVETSTVKSTTTNLGRTSTTTSTVDLSTFIDVRTSWKMETSTTSSITTKFITTTITRPPSWIAIKGDPDWRPRKRAEKNDGFVNVEALTNNQLPQSVRCVREIPKYSTKTVVTTVKGPRITLKAATKTKTSTVPTTITVTDYPNARITATEISYRSVTTIVRDVTSTSTIPETATVESLIPTATAYDMCSDDNILVTANGGIRPGYIRLPYSGDFNPIQIGVGYTGKPCCIACASNPLCVGSYIEDGVCKIFVPKDSDMCLNGGQDEIGGYMTYQELDSGFDIIFSNGPCGKFKNYGISANQD</sequence>
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S8 family.</text>
    </comment>
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        <property type="protein sequence ID" value="SCB65043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21981"/>
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        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
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        <property type="entry name" value="Subtilisin-like serine protease"/>
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        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
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        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
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        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
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        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
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        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
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        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008687569" evidence="7">
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            <begin position="21"/>
            <end position="414"/>
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    <feature type="domain" description="Inhibitor I9" evidence="9">
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            <begin position="38"/>
            <end position="117"/>
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    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
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            <begin position="168"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SCB65043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="414" mass="44554" checksum="9FDA23A6FB780E1F" modified="2016-11-02" version="1">MVNLKNIALAVTLFLGCGLAVPAPAAPAAEPGDIIPGSYIITLKPEIDAVMAKTHLKWVDGVHKRSLTKREELGVEKTYDSKSGFQGYAGTFDSTTIKLIKQSPEVLAIEPNRVWKISRVNKDHNLQKRAEVTQKKSTWNLGTISHRKKGFKEYIYDNYAGTDMYAYVIDGGVRVSHNEFGGRAKAAWTNWKGDNKDTDGHGTHVAGVIAGKTYGVAKKANILALKVFKGEESDTSIVLDAFNWAVNDIIKRDRTWRAVINMSLGGEKSVAFNRAVDNASKKGVVTVVASGNDAIDAAKESPGSAATTITVGAIDENWAVADFSNYGKTVDIMAPGVGILSSGWKSDTHTFTEDGTSMAAPHVAGLVLYAMSVVEVEGVADITAWLKEFATPKKISGNLRSAPNLIANNGNWVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLL6</accession>
    <name>A0A1C3YLL6_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T25805</name>
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    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YLL6"/>
    <dbReference type="STRING" id="229533.A0A1C3YLL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25805"/>
    <dbReference type="eggNOG" id="ENOG502REQ2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YLL6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB65324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="707" mass="78523" checksum="B4C8752114BA9BDB" modified="2016-11-02" version="1">MDGLSIATACFAFIEIADKTFTVISDFVRDCKDARNDLAALNQELLSLKRTLNLLKDLVTDGNESDLTNNTKRDIRDIIQNSLGIASTLENELRGQQGRLLAVHWATRGKRKVATYQVILETNRRALSLAVETITLATAKNIKQDTTEILDDTAHIRGGITSIISRIQTLEAIVTSQGTGDPHTFMLTRYLNELSSVAGSVCDPLSRSTSPAPSESSTPPHDSSTSAASYDSGVGEGSQPVNTPSGLPTDKDVPPVSESEASGKSPTDLANDPFVLPDSFPVSVTEACSLENLAFQLRQSHFLSKHLQIEQETYPTGLSSDGNRLVWLQPGKKHDVVYDTESKRINNVMSMGTVDRFRQSIHKTEMRILNTDASLILFKISKSCWKVYDRVTGKTIRQDFFNSLATWTQQIVPVSKDCGLLLLGHYRKGYTLNRIRRSSRGAKGLVWNYKVLPSSGDSILHHVTLSVDSQNVTGLLGDAQQLAAYTWDIPSEWFADEHIVVFPYIGSPVTVDLHQEDLKNHERTLGLTSTRGRVIVIKGGVDRRTSYHAGFRNTYLSATTFNIDSGAEISSYSFSVSRIHGDDNKDSFFKDAKISADGKLLRTRIARTPGIGKRSTPEFKRQAWIGVETVILRVEGLEVVHQFKEVWNANFTEPVTLSIFAPNFDVLARLAWKRRGEDKKQRVWLEVYDLKENLEEDEAVSKVESVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLT2</accession>
    <name>A0A1C3YLT2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T26363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YLT2"/>
    <dbReference type="eggNOG" id="ENOG502SN7S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YLT2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB65378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="457" mass="50987" checksum="D255A3533076E00E" modified="2016-11-02" version="1">MVTTNLFVTFDIFCILTSSPVESSLFAPARRYLTSIQSLEETSISSRSTSCLESSPSTFHSPLHLLWYYCLSTPPFLPLAHEPHNRPTTVRGHQPLPCTSSKPLGQPAYDPWSRIRATTVDVVRLSSFDLSPHRLLPHATSFISLALWLFSFSLGLHSQLEPRELLLLALQDTYGSSETGACSPSPSWCSTGKPDHFPTRCRYLLPPRSSVDFDTARAFKSQKYSYPGKAVIRMDPDCAICHAPANMACECEAKGLDVAVKQAEDRMMRSIYTEIRSWVRGHAQDYILEYFRLLTDQRKTAHAAHMDRITAHAYHYYHAPPHPTQVAEAQASLKRGIDEDWQASVQRYPEVLEYFFGLVELTLPAEDEPAVKEPPLGSLSNLRKVNRRNSNNPPGAAGAVVPPGYRGDPGPMHQEPPPMPMPRADRRTPGPGMRRPNFGAPPPMPGGYNYPPPPPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLZ4</accession>
    <name>A0A1C3YLZ4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T09061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YLZ4"/>
    <dbReference type="InParanoid" id="A0A1C3YLZ4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB65555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="152" mass="16975" checksum="2557BD794644DA0D" modified="2016-11-02" version="1">MRVSSSVDTAIKPHSHHLKGQQSKLLHYNISLQSQTFNPTIAIMRLAAIIAATGVIFTASVSGLACKDGIKYCSYNLNSGGHFWTEDEIWSQLQSEGLPDGYTKGHIQHTLFKCQDRWYWSKAHLYYVEWCANSCQNGGGGKDDLCRPHAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMA0</accession>
    <name>A0A1C3YMA0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T09027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YMA0"/>
    <dbReference type="eggNOG" id="ENOG502SB8S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YMA0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="65"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB65553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="158" mass="17766" checksum="6F320C0F80084856" modified="2016-11-02" version="1">MCNGRVDILKRGQVSRFQSRHHEKPLFLPSFCIFNRTTYSLPLLKMPIINADVPPTSTDDTHYVVYFASGEPSWCPDCRNALPALNAVFGDASAPNAHLVMAGSREEWRGNPDNKYRKAPYDIQCLPTVVKVKYGAEIGRLGDNESQNESDLRKLVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I1R9W9</accession>
    <accession>A0A098CZY4</accession>
    <name>I1R9W9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG00283.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T00763</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315929.1">
        <property type="nucleotide sequence ID" value="XM_011317627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1R9W9"/>
    <dbReference type="FunCoup" id="I1R9W9">
        <property type="interactions" value="526"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1R9W9"/>
    <dbReference type="EnsemblFungi" id="CEF72183">
        <property type="protein sequence ID" value="CEF72183"/>
        <property type="gene ID" value="FGRRES_00283"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00283"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00763"/>
    <dbReference type="eggNOG" id="KOG3662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011607_2_0_1"/>
    <dbReference type="InParanoid" id="I1R9W9"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="567"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF72183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="689" mass="78211" checksum="690B4333C62DEADA" modified="2012-06-13" version="1">MSRPYQYRTSSKIPRNLQSIGHVLSVNAQHGAHQLRMWAAGPGKRMALRTGERVMRRLQRNLTSRRLLSFPHLLVLFWLVILLYGERWVFNSKVASCDWDHWEKWPKDAKPHHLVFVADPQIIDPHSYPGRPWPLNPLTVLITDNYLRRGYRAMQSRLHPDSLFFLGDLFDGGREWKTREGKFVDPKWGRGRSKDEKKLVELWHNTYGEDFWLHEYERFGDIFFKHFNDGGEVPGSWQRGRKLVASLPGNHDLGFGAQVQTSVRDRFEAFFGDVNRVDVIGNHTIVSVDSVSLSADTSEYKNKHDLKPIFGPVNEFLDGVKTLKRKAVEEELRHYYDLKGGLRYPHNVEELDRSKPTWGKSAEADKGDGPEFPTILLTHVPLYRAPGTPCGPQREHWPPTTPPKGQKEPVFPDNRNALSVVGGYQYQNVLNELDSIKLVKSIGNIKHVFSGDDHDYCEVVHSDAKENVREITVKSMSMAMGVPTPGFLMVSMFNPVDSKGKPLPGSPEQTIQTHMCLLPNQIHTYMEYIVFGVATLVLLVVRAALVPALSLTPFALEPEKHSSSSVLPVYKDKMDPPEASTYRNTTSSGTSAHHFPSRAAPRHGRSASPVQTSGRWQARRGGRNDKRWGWGSAGGPRIHLDDNLYTTGVRDKRIGGKKALGVIGRELWTTAWRVVWTVLLFFAYLAWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RA48</accession>
    <accession>A0A098D055</accession>
    <name>I1RA48_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG00372.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T00983</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316034.1">
        <property type="nucleotide sequence ID" value="XM_011317732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RA48"/>
    <dbReference type="FunCoup" id="I1RA48">
        <property type="interactions" value="627"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RA48"/>
    <dbReference type="EnsemblFungi" id="CEF72294">
        <property type="protein sequence ID" value="CEF72294"/>
        <property type="gene ID" value="FGRRES_00372"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00372"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00983"/>
    <dbReference type="eggNOG" id="KOG2154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015945_1_0_1"/>
    <dbReference type="InParanoid" id="I1RA48"/>
    <dbReference type="OrthoDB" id="10263185at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="317"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF72294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="545" mass="62550" checksum="84A733351DA305FB" modified="2012-06-13" version="1">MSKIVSERSKRKRSSVQEEPTKRRRSSVSSDESEDPNAKILLMEQGILESRKNYNDITVLLTTANGFKDGDSESMLATVALCRIFLRLLAQGSLATKKSLSEKDQVIVGWLRKQFGEFKKTLVTILRDEELAPTALTLCMRTLKAEGASFNEKDDYIFPRSFLRDIVLSLIESENTEVMKAFVEEYVEQYDDIRYYTLDAVKHIVKEQESDPSPGLFDRCFALLSALDGVPESAEQLEDFYVPKPKKKTHNLRNVNQHKKQGQEAWLALMTLMDKKEQRQRKQILDIFTTVIAPWFTKPELLSDFLTDCYDAGGSTSLLALSGVFYLISERNLDYPSFYAKLYSLLDRDILHSKHRSRFFRLLDTFLGSTHLPAALVASFIKRLARLSLNAPPGAIVFVTPWIYNLLKRHPTCTFMIHREIQDPEVKKHIDEQGAKDPFLPNEADPMHTEAIDSCLWELVQLQSHYHPNVATISKIISEQFTKQSYNIEDFLDHSYATLLEAEIAKEIKKAPVTEFHIPKKVFFANEGADEPDNLFVKLWDFGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1RAX6</accession>
    <name>I1RAX6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG00670.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T01689</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316366.1">
        <property type="nucleotide sequence ID" value="XM_011318064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RAX6"/>
    <dbReference type="STRING" id="229533.I1RAX6"/>
    <dbReference type="EnsemblFungi" id="CEF72645">
        <property type="protein sequence ID" value="CEF72645"/>
        <property type="gene ID" value="FGRRES_00670"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00670"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01689"/>
    <dbReference type="eggNOG" id="ENOG502SDD8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059602_0_0_1"/>
    <dbReference type="InParanoid" id="I1RAX6"/>
    <dbReference type="OrthoDB" id="2103031at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF72645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="306" mass="34443" checksum="4AAB1443A04A4631" modified="2012-06-13" version="1">MGWISSILGTDKSADPLAKLDPSLRDFLEKESPLKYPANQPAHPAQAVQKPSNTNVTVAETQGQKPAAPSASLYKDGRYAHLWKSYRPLAEIEAETASDHEKLMSVLEAYKERKEAIGKAALENCAEYQEEWVNCMKHGSWEDQIQMCRNQVRSFERCYLMQSRFLRALGHGSVVGRSPEIEDDIQMHADALYQRMIKHEEAVEKAKAEGLPVPVFQSKLPKAKDDSVVPTEELQQQWKEQLDKLPAEERAVEEAALRADLQVKAEVAGNVQKIWDTQAEQRKQRQAEGNSTFGDYMASLFGKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>I1RBH2</accession>
    <name>I1RBH2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG00895.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T02255</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316629.1">
        <property type="nucleotide sequence ID" value="XM_011318327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RBH2"/>
    <dbReference type="STRING" id="229533.I1RBH2"/>
    <dbReference type="EnsemblFungi" id="CEF72929">
        <property type="protein sequence ID" value="CEF72929"/>
        <property type="gene ID" value="FGRRES_00895"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00895"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02255"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_10_0_1"/>
    <dbReference type="InParanoid" id="I1RBH2"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="36"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF72929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="480" mass="52165" checksum="69388EFE914486A1" modified="2012-06-13" version="1">MTRNKFSSLRDQLVQGKLLLPGDEGYDQSLERWSRTCVKPAAAVAQPRTAEEVSAVVKFATSNGIKFNVKGGGHSSSQTSSSPSPEGMVLDLSLMRDVSVDADAQTITYAGGCLWKDVDDALWAKGLATVGGTVSHTGVGGLTLHGGYGVLSGLHGLAIDNMIACQVVLADGSIVTASASENPDLFWALRGAGSSFGVVTQFTSKAHPQGDIWGGMVLFSPDKLPAIIDFTNTWGATNDGRQILLVAFGHAPPGPDPNAPRPPVVVVRMAQVGDNPSEEGPKYFAPILEMEALMQEIGPMPYPVINQVADGQVMHGSRYLFGGSNFTLPMKLSTAETIRNRFHEFTERTPDATESVVLIECIPNQKIREIPVESTAFNSRGKYFIIGFMYKYEDESLDTEIRQFNRTFQTEVRKLGYNDETLADGIGNYLNYANTGNISAEEAFGSHSKRLVTLKKKYDPENVFDKLWKLVGKVEDNWIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>I1RBX3</accession>
    <accession>A0A098D3V2</accession>
    <name>I1RBX3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG01066.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T02661</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
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                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_011318521.1"/>
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    <dbReference type="STRING" id="229533.I1RBX3"/>
    <dbReference type="EnsemblFungi" id="CEF73132">
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        <property type="gene ID" value="FGRRES_01066"/>
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    <dbReference type="KEGG" id="fgr:FGSG_01066"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02661"/>
    <dbReference type="eggNOG" id="KOG0236">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="entry name" value="SLC26A/SulP_dom"/>
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        <property type="entry name" value="STAS_dom_sf"/>
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        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SULFATE TRANSPORTER"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
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        <property type="entry name" value="SLC26A"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF73132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>I1RC74</accession>
    <name>I1RC74_GIBZE</name>
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        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG01177.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T02925</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblFungi" id="CEF73263">
        <property type="protein sequence ID" value="CEF73263"/>
        <property type="gene ID" value="FGRRES_01177"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01177"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02925"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_018986_2_3_1"/>
    <dbReference type="InParanoid" id="I1RC74"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:cystathionine gamma-lyase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:pyridoxal phosphate binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000043">
        <property type="entry name" value="Cystathionine gamma-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF73263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="423" mass="44792" checksum="82C81436A638B3DF" modified="2012-06-13" version="1">MSSAPLNSDPVATPPRPPSPVHNFGTLAVHAGAPHDPATGAVIESISLSTTFAQSAVGKPVGEYEYSRSSNPNRTNFETAVAALEHAKYALAFSSGSATTATILQSLAAGSHVISVSDVYGGTHRYFTQVAKAHGVKVTFTPEIEVDIAEHITPDTRLIWIETPSNPTLRLVDIRAVVTEAHKHGVLVVVDNTFLSPYVQNPLDFGADIVVHSVTKYINGHSDVVMGVAAFNSDELKARLSFLQNAIGAVPSAFDSWLAHRGLKTLHLRAREASRNADAVARALEASPLVIAVNYPGLDSHPHRHIAKKQHRDALGGGMLSFRIQGGHAAAERFCQVTKIFTLAESLGGVESLVEVPSSMTHAGIPRDQREAVGIFDDLVRISCGVEDAQDLTNDVLQALEKATSAAKANGLNGNGVNGSNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1RD97</accession>
    <accession>A0A098D732</accession>
    <name>I1RD97_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG01589.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T03881</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317406.1">
        <property type="nucleotide sequence ID" value="XM_011319104.1"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF73746">
        <property type="protein sequence ID" value="CEF73746"/>
        <property type="gene ID" value="FGRRES_01589"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01589"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03881"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001540_1_0_1"/>
    <dbReference type="InParanoid" id="I1RD97"/>
    <dbReference type="OrthoDB" id="21416at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="70"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
            <begin position="341"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="567"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="705"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="949"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1234"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1551"/>
            <end position="1587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF73746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="2087" mass="231734" checksum="9835BB4410A5A3D6" modified="2012-06-13" version="1">MSDKQTYRPASPEGSDTVVIGTEDTSNYNLGHVLPESDDIIASIREWLCPTEYDHEGSEYRKHLAFHLEGTGEWLHRSENYQQWYKTPENGLLWIKGVPGSGKSVVAASLIHKLSQEQVPVLYFFFRQIIDANHRPVNLLRDWLDQILLYSPPLQSSLKKYVDNSRSLDSVSINALWKHLKAALSSIPRVYCVADALDEMDDENNDFIAQLAEFGHMKPSSIKVILTSRPTANVEAAMRGIKSLSIRMEEKLVDVDIAAYVRYCLANSSIDEGDRQLVKEAVPGRANGLFLYAKLAMNAFLEPGANVRDTIHNLPLDLDTMYIGLLQEHARRSGISEKTQVMILQWVTHATRPLRLLELADMLGTAIVDREPHTLKEDKDLVRAACGPLLEILPDETVSVVHHSLTEFLIGTHRTERPGDYPILDSSATHCDLAVVCLDYICSGWLRDQDIRMHSLRSDHRRITLNFPFAAYAISNWNTHVRRSKWTVSHADILSQKIDRFMNDKKTRYNWAKICLNHGFYRRNGDSYVKSLSDLHMAALCGLAPTIKSHIDCQGLRDQALDMPDAQKRTPLWWAASGGHTDVVDILLQHGASHTIADISSGFRPVHAAVMKNKHQVVRLLMEKETVTTLQKPPVDASGEVPELGLTILEFASAQGHLRSLEAVLPFYDAIDKKRALFEAIDAEKLHVTKLLAHDTDVDVNERFEGKTALFLAASRCSFEIMETLIDAGADASIKCRRKRGADPDEKIVLSTVLIEFFRNRRLLTRRSAGRPLGLQLEPSNFTHMLNLLVNAGADLNERDSMGMSAIHSTESCDALKCLIDAGADPTARSRDGRTVLHYLPEDIDEGYLEFLIESQNGGINEREHYKGRTPLLLALQSHPALAMLILQHGSDCTMADFEGNGPLHYALSFCKGRCRPKPSYGPEDEGNLLKLLKALLEAGADPRLANSNGETPLHVLAANCLDGHILDTQDLECIKETMRLLLHHGADIDARDTKGRTPLFRLAGRNFRHTNEVKPLFESFVDESADLKVRDNEGRSLLYEAVYSITLGGNLNGTLALPYQYLIDVGVSPLVADFKGNTLCHELILAPNCPTLKGSEEFFFPIFQEAGVGIDKPNFSGTTPLHLACQMRTDGAYGINIKTQDCFKWLLKQSSDPNISDKQGLTAIHFAASTDTYAVDRLLRAGADPFAVTDQGMNVLHIASRCRRSNNLGILLQWMKDSSPEVLNTALNQKDICQYTPLHYACRSGVIESVRFLLEAGADANPTFEAAQETYLNEPWFPPILQCVFLKSENSLWERGPLDRDPSSDEMDGSRGHNLIAGGYTVENTTRNFDGIFSEPQIKDSDPEFEVSGYDDILNALLAAGADLSQTGHDSTPALYRAMMFAADESDDYVLSLLWDISEKAKMDELPATIDVAITLARARHRAEITVLSDAFLPRAKEITWEAVARLLSGHQFSLITDLYKAGANFTTPSVEGVSILHRFVQYGLNQLIDDCYYPQEAAMPEKGQQVPERNQDGLESLLMVACRRSTSNMEVIRILVEKKGVNIKAQGPNGITALHILAVGKYWWQHALAIPYLVSKGADLEARNTDGCTPLLYSSTQWGAFRAAAMNTLIDYGADVNVLCNRGLGCLNHAAQNEGLVRLLVSHGAEVLPMTIMDAIQQGNVDTLRILLSGNGQPGLAALWKLKLDDAEYMDLDANPLQAQLIRQGHPLFTASTEGAAFMPSVSDTLSKVRHSVKGEMMKALMAAGFSPYDTFAFRPVYKRCAPYRPSLPMAIANQAWQEKDEEFGIISGLGLGSSRLTNRVVMHEIFSSDSGYYEPILEFTDLDLEFRDKAGRTLLLASCRRRDYSENIPLKLLLRRGADPFAVDNQGRNVVHLMLGSSALDDDMLKAIKDLGDALPDLINQCDAKGYRPLHYGLAAVAASGSLHAEASWVDYITTQGADMLAVDAHGNNALHYLASIIFGHSGYSGDRTEILFKKFINMGLDINARNRAGQTPTFFVVGDLRNQPVVREKINWLDGLGVDWQARDEQRRTILHGIAGEPAELFKAVMHRGVDPLAEDIDGRTSLDLAAGLENYEVLKLFDRADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1RDC5</accession>
    <name>I1RDC5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG01619.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T03955</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317444.1">
        <property type="nucleotide sequence ID" value="XM_011319142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RDC5"/>
    <dbReference type="STRING" id="229533.I1RDC5"/>
    <dbReference type="EnsemblFungi" id="CEF73784">
        <property type="protein sequence ID" value="CEF73784"/>
        <property type="gene ID" value="FGRRES_01619"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01619"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03955"/>
    <dbReference type="eggNOG" id="KOG2427">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007080_1_1_1"/>
    <dbReference type="InParanoid" id="I1RDC5"/>
    <dbReference type="OrthoDB" id="10261212at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007518">
        <property type="entry name" value="MINDY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033979">
        <property type="entry name" value="MINDY_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063">
        <property type="entry name" value="NF-E2 INDUCIBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04424">
        <property type="entry name" value="MINDY_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MINDY deubiquitinase" evidence="2">
        <location>
            <begin position="274"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="773"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="805"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF73784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="831" mass="90429" checksum="13C2DAB15E7734CC" modified="2012-06-13" version="1">MSNNPWAEGGNDNGWEDVGPRRNGQPASTTNPQTIPTILRPGGAFDNQDEQQAWGETRTQPSDQRNPQEAPGALKPDRTGTNPFLRKQIPQRQEEPPTDTFARLGLDEPNTNPWQPAMDAQHTLLQPQAPAQPIPSLLDDNIPRDRWTPTPEPLPAGSPGMVSLLSDRGSSAWDEDPLGKNEKPPVPPMKLSEEITGDTSIWDDASGEKGKANATGEARSGSPDDWNLIESEPATSPINEPSTEKPPLPPRQPTLPTDGSSWRPSRDPVDGKTETYQIKNIHWHDSSSSKNPRISPILIQNANGPCPLVALVNALTLTTPADIEDTALVQTLRSREQVSLNLLLDAVFDELMSPRRTSSEDALPDVGDLYAFLQSLHTGMNVNPRFIPTESIQEAYKRTSLTHLHPAERGDLIPGTFENTAEMGLYATFSIPLIHGWLPPRNEHAHDALERQAASYEDVQNLLFREEELEQKLSDPEGGLSESEQQLYQDIIIIKEFLENSATQLTPWGIEVIGKAIRPGTFAILFRNDHFSTLYCHPQSMQLITLVTDAGFKSHDEIVWETLSDINGGNTEYLSGDFRVVGSGGAGPSTSAGNYSSNDGGEWTTVQNRRGKAPEAGEAPMSPSAEQEDRDLALALQLQEEEEERHRAEEARRRRESMLSEQFIEQQALQPPNATRGNRGGRGGRGGGQPGRGAPRGGGVTRGAGGLVPGRNSSVSAPTTNTINAQPGMPTQRVRSLIPNQPPRPAVSRPADEAADDAPPSYEQSAHDRTYQPPMGHPSHPGSSPTISRQTTAASVNPSMPMGQRPFVPVGRRPGVGVNGAPQKERDCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RDH9</accession>
    <accession>A0A098D7C2</accession>
    <name>I1RDH9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG01675.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T04077</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="9 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="gene ID" value="FGRRES_01675"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1RDR5</accession>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
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                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
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                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
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                <consortium name="EnsemblFungi"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF73969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="401" mass="45583" checksum="8077C7259CF91E17" modified="2012-06-13" version="1">MNWSLIAFPLIPILCLVALALWSKVDENLCPKIIKCKDPCVVEADPDIAGIGVRIATYTQTICNIILLGFASDGNRTSASYHALVLTSLATIITLGIFSIQTKLSLHHSVVASSLLTITILPTHILESWRVRSPGIFVAQQVRLAIYCAYAWWLILEMPCMGAEPQCNLCTRSSLFGHASRVATHGNRSLRLGVVLFTSYLWLRQVVWSYGPRHYFESVPATLSETRKQAWNSYIDENRDSLTTWRLRRLARERKYDQFSRFLIPGWLWYDDVTTARRGIEQRRWKRFLPLDKQKVNWFVRVWEDATVAIRVPRCQRAIVALLLSVLLISDTEHTVKLNLSADRDQWGYGQILALVATIPSVADVTRLLLRLGKRPYLVIPFKENIGNCGNRGVSDDGLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>I1REE1</accession>
    <name>I1REE1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG02029.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T04901</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317901.1">
        <property type="nucleotide sequence ID" value="XM_011319599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1REE1"/>
    <dbReference type="FunCoup" id="I1REE1">
        <property type="interactions" value="1189"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1REE1"/>
    <dbReference type="EnsemblFungi" id="CEF74257">
        <property type="protein sequence ID" value="CEF74257"/>
        <property type="gene ID" value="FGRRES_02029"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02029"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04901"/>
    <dbReference type="eggNOG" id="KOG0418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_13_1_1"/>
    <dbReference type="InParanoid" id="I1REE1"/>
    <dbReference type="OrthoDB" id="9993688at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14311">
        <property type="entry name" value="UBA_II_E2_UBC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015368">
        <property type="entry name" value="UBA_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09288">
        <property type="entry name" value="UBA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF74257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="234" mass="25978" checksum="B25D7055A81C1CC0" modified="2012-06-13" version="1">MSRDRRIMKELADIQHDHDSSGVNAILVSEGNMTHLKGSFPAPPDTPYSGGTYTIDIQIPDQYPFKAPSMRFDTKIWHPNVSSQTGAICLDTLSSNWSPVQTIKTALLSLRLLLECPNPKDPQDAEVAKMMMDSPERFAAKAHDWAVQHAGAPRRDVDLSQYKSEGAPAPPKVDAARYMGYNKDLVERFVNMGFPLDNVVEAFIAIGIERNGGRDYVLEEAYMGDIVARLLGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1REG2</accession>
    <name>I1REG2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG02050.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T04947</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317923.1">
        <property type="nucleotide sequence ID" value="XM_011319621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1REG2"/>
    <dbReference type="EnsemblFungi" id="CEF74280">
        <property type="protein sequence ID" value="CEF74280"/>
        <property type="gene ID" value="FGRRES_02050"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02050"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04947"/>
    <dbReference type="eggNOG" id="ENOG502SW30">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118191_0_0_1"/>
    <dbReference type="InParanoid" id="I1REG2"/>
    <dbReference type="OrthoDB" id="4158189at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF74280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="165" mass="17417" checksum="3E999D506ED4A050" modified="2012-06-13" version="1">MCGPENINRPRGGALVSLNPPTNSTSTRICGDLAFHTPGSPASSNATHARLTPNEECSIDKFSDLQVIIHSTGDLTRNASECGLFRQFSLPTSPPTSNNFVESQLQGPLSLEVGGDGIIGRRVSVYSRLSTGHVKIVAEGIVGFNFMSQEIPQDSSCPSSPSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I1RGN2</accession>
    <accession>A0A098DF64</accession>
    <name>I1RGN2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="primary">FG02904.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T11581</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322898.1">
        <property type="nucleotide sequence ID" value="XM_011324596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RGN2"/>
    <dbReference type="EnsemblFungi" id="CEF77594">
        <property type="protein sequence ID" value="CEF77594"/>
        <property type="gene ID" value="FGRRES_02904"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02904"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11581"/>
    <dbReference type="HOGENOM" id="CLU_1796640_0_0_1"/>
    <dbReference type="InParanoid" id="I1RGN2"/>
    <dbReference type="OrthoDB" id="5079939at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF77594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="172" mass="20350" checksum="8CFCAF32333B4F63" modified="2012-06-13" version="1">MAVHRHHHHSTPTSSKHHQRRHLFVYTSMDHQQLEPPLPVVYSNKIVFRHSFLKWVINEAFSGNPSSFNVIVQKPCEHWLAENFIDESVTGCQMICIDKPKLYDIAAEHWDNNILAPFDFRRKRLSHNCFAPSDTPDPVIILAYRWISNSDCPWLWGQYNEFNDCLLVYWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RGT6</accession>
    <accession>A0A098DFG7</accession>
    <name>I1RGT6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG02963.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T11719</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_011324530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RGT6"/>
    <dbReference type="EnsemblFungi" id="CEF77663">
        <property type="protein sequence ID" value="CEF77663"/>
        <property type="gene ID" value="FGRRES_02963"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02963"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11719"/>
    <dbReference type="eggNOG" id="ENOG502RN93">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_956557_0_0_1"/>
    <dbReference type="InParanoid" id="I1RGT6"/>
    <dbReference type="OrthoDB" id="5072283at2759"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="291" mass="32391" checksum="187F871920272569" modified="2012-06-13" version="1">MSANSAENNSPGLVEVASASASNPVQIILTPPTPIIPSGPAAIDRRSEDTNKEVHRLPDVSEEKEVVAKTDFSDEKQVYNEHDAHDEKQVYTSDIGKEVYDVGVEKKVQNLKLHDGHDEKQIFDPSLGVHDTEKEALYIQNLHDVDQRRHSNSTESTETSQSQAKTKPFCYKRHVGKFNEAIDKKKKAWTTFSNNSSTAMSEKIIQMDKGWKQRVDVFEESTMAKMSAFDKSINDGFDRAGKGYNSTISSWKTGVINKRNQSISSMKSLGSKCQVGGKGGKEDATDDKFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1RGZ3</accession>
    <accession>A0A098DFP5</accession>
    <name>I1RGZ3_GIBZE</name>
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        <submittedName>
            <fullName evidence="6">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="primary">FG03026.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T11881</name>
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    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322760.1">
        <property type="nucleotide sequence ID" value="XM_011324458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RGZ3"/>
    <dbReference type="STRING" id="229533.I1RGZ3"/>
    <dbReference type="EnsemblFungi" id="CEF77743">
        <property type="protein sequence ID" value="CEF77743"/>
        <property type="gene ID" value="FGRRES_03026"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03026"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11881"/>
    <dbReference type="eggNOG" id="ENOG502RQRR">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_002707_1_1_1"/>
    <dbReference type="InParanoid" id="I1RGZ3"/>
    <dbReference type="OrthoDB" id="2099582at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031250">
        <property type="term" value="C:anaerobic ribonucleoside-triphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Aldolase_TIM"/>
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        <property type="entry name" value="NrdD"/>
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        <property type="entry name" value="NrdG2"/>
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    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
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        <property type="entry name" value="rSAM_sf"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PRK08270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANAEROBIC RIBONUCLEOSIDE-TRIPHOSPHATE REDUCTASE"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="623"/>
            <end position="825"/>
        </location>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="825" mass="93006" checksum="05EC49E05BC9D31C" modified="2012-06-13" version="1">MSSNVALVDEYLAKGTWKTAENANSTYSHQGLMQYVSNQIISQYWLEKIYTPEIRQFDAENRFHIHDLGFLSAYCSGWSIEDILLQGFGGVENKIQCRPAKHLNTALNQIVNFLFTLQGELAGAQALSSFDTYLAPFIRSDNLSYTEVFKCVQSFVYSLNVPTRSGFQAPFTNLSLDLICPARLGDQCAIIGGELRTEWVYKDFQEEMDMLNKAFAEVMMQGDGNGNIFSFPIPTYNISDGIDWDSPRWQSIWEMTAKYGVPYFANFINSDLDPEDFRSMCCRLRLDLSKLHCRVGGQYGASPLTGSIGVVTLNLPNLAYRSKGSRETFMSELAVTLRVAKDSLEIKRKLVDANSTLYPYAAHYLSATKHRTGSFWTNHFSTIGVNGMNEALVDLLGEGIGERKDFALEVLEFIKDQLQVFQKETGNLYNLEASPAESTCFKFAKRDKELFPDRNIPTFYTNSTMLPVDTTEDLFEAMSHQEELQCSYTGGTVFHAFLGEQLPNWKLARDLIKTLTARYRIPYITLTPTFSICPVHGYRVGEQPECAACGELTLVYSRIVGYFRPIRDWNRGKSKEFVQRKVYKYETGLLPDTNSESVRLENQVAAIHDLPVAGFIKSTLSDYPGKAQASIMFTSRCNLACPWCHNGPLVQGDRDGVSLLNVFKHLNSSSHKCLVVSGGEPTIHKGLLPFLRILKNAGISVKLDSNGTSPDVLKQVFAEKLVDFVAMDIKCALENYRRVTGKKIKPKLLETSIELIKNSGVPHEFRTTVVPELVDVEDLFEAKRLSGEKLTVQRFRNGNTLLDESFRSQREHTDEEFDQLVSQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1RHE4</accession>
    <name>I1RHE4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG03193.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T12281</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322567.1">
        <property type="nucleotide sequence ID" value="XM_011324265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RHE4"/>
    <dbReference type="EnsemblFungi" id="CEF77944">
        <property type="protein sequence ID" value="CEF77944"/>
        <property type="gene ID" value="FGRRES_03193"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03193"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12281"/>
    <dbReference type="HOGENOM" id="CLU_2133727_0_0_1"/>
    <dbReference type="InParanoid" id="I1RHE4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF77944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="113" mass="13021" checksum="88ACFE29C5A31EE7" modified="2012-06-13" version="1">MSSKELQYGPLPEDEALYLWMQNRCSVSWPKVLPPELYQPPSPSPRPASPKQSTVVQNSYLLSLPLECLQQIILLLDIESVFQFRRTAIEYMEKGLSALCSCERPFWLPNTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1RHL5</accession>
    <accession>A0A098DHY7</accession>
    <name>I1RHL5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG03274.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T12479</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322474.1">
        <property type="nucleotide sequence ID" value="XM_011324172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RHL5"/>
    <dbReference type="EnsemblFungi" id="CEF78042">
        <property type="protein sequence ID" value="CEF78042"/>
        <property type="gene ID" value="FGRRES_03274"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03274"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12479"/>
    <dbReference type="eggNOG" id="ENOG502S1Y6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_330382_0_0_1"/>
    <dbReference type="InParanoid" id="I1RHL5"/>
    <dbReference type="OrthoDB" id="3886018at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029167">
        <property type="entry name" value="Mug117"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15474">
        <property type="entry name" value="MU117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124254" evidence="2">
        <location>
            <begin position="24"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="569"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="593"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="617"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF78042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="884" mass="92407" checksum="6554B9F12B3501E8" modified="2012-06-13" version="1">MQQPWKLRVLALCLATGLSGVSAQGFTTSTYDTMTGTETSTDAGLPVVDPTPSTELALPETSSGPFVEAPPSEATSEAHVEIGTSSVGDDETSIPVAPPTEQTTSPFGSATESVHQQPSTGTQTDAIVPPMETQSQQPDTATGISSPIDTVTGPVEVADTTTGPIEAPTQPAQTGPVLDTTTDQVLPVTEGTTNIQPPVISTESTEATEPTTQVNAEPVVSSGSTDAAQATVSVPAPENTIETTAQAAEPTSEVKPQEPSTEANDIPIKSTTQQQAPEHTSQEESPEQTSQSKDTAETTQGAPDPKPTEDKNEVPSTKNEPGQTSAPDEPEKTTANPDPTPTEDGIVTGTDGAVVTYVPEQDKDFSDFTGTTTTTDDGGAAIVIFPGGWFWKPSGNLPIGNLPGPPGSIPGPVGGGGGGGNGEGDGDDKDEDDKKSTKEEEEKSTAEPSKTTAQTTAKSTEATTTSTEGCSAVEIEDCTRTISYYTTDGTLTHTEFGDCPTIASCATGTQATATTTASAEYEEGVEVQIDEADVDIPDDFDGDVSDDTAQRFQEVMDEYWADYGVSTGTETTAEATSTSESAETTSEVKTEETTTTEATTDMTTSVPSTLITMTRNTESSQESSGTTSDGTSSDMITSIASSTEVPTTTTSSHRTYYPCVPHGGPRIATPYCQCETTSDGKQMVATAPLVSNACDAYTEFPASLYTTPPPAPTPTVFNEPYTMTNAGTVLVWESYSLREWKIMGHPVTNTIGLGEASTVSTPVPTATDTNGDGSDICTSIDKNVRNALSGACNSALDQFEDDTIYDKYTGRYAQMGSILKALTFGKASCIVQFSCDDYGIGMKGSDIKKIREDNRDSVGRCGNIYLSNSCKIHLDYCTECNKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>I1RHQ4</accession>
    <name>I1RHQ4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG03315.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T12585</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322424.1">
        <property type="nucleotide sequence ID" value="XM_011324122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RHQ4"/>
    <dbReference type="STRING" id="229533.I1RHQ4"/>
    <dbReference type="EnsemblFungi" id="CEF78095">
        <property type="protein sequence ID" value="CEF78095"/>
        <property type="gene ID" value="FGRRES_03315"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03315"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12585"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_4_1"/>
    <dbReference type="InParanoid" id="I1RHQ4"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="PHI-base" id="PHI:5898"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124223" evidence="7">
        <location>
            <begin position="21"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="9">
        <location>
            <begin position="35"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="161"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF78095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="411" mass="42713" checksum="A40A8199FE603E32" modified="2012-06-13" version="1">MTSFRRLALALGALLPAVLAAPTEKRQELTAAPDKYIITLKPEATENKIEAHLNWVSDVHRRSLNKRDTSGVEKKFNISSWNAYSGEFDKATIDEIKKSPEVAFVEPDYTVYLDFETELTDRALTTQSGAPWGLASISRRTSGGSTYTYDTTAGSGSYGYVVDSGINVNHRDFGGRASLGYNAAGGAHVDTLGHGTHVAGTIASSTYGVAKAANVISVKVFTGNSASTSTILAGFNWAVNDITSKGRAGRSVINMSLGGPSAQTWTTAINAAYNSGVLSVVAAGNGDDLGRPLPVSGQSPANVPNALTVAAIDSSWRTASFTNYGAGVDVFAPGVGILSTWYTSNTATNSISGTSMACPHVAGLALYLQVLEGLSTPAAVTNRIKALATTGRVTGTLNGSPNLIAFNGAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1RHW5</accession>
    <accession>A0A098DI97</accession>
    <name>I1RHW5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG03381.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T12745</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322345.1">
        <property type="nucleotide sequence ID" value="XM_011324043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RHW5"/>
    <dbReference type="EnsemblFungi" id="CEF78175">
        <property type="protein sequence ID" value="CEF78175"/>
        <property type="gene ID" value="FGRRES_03381"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03381"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12745"/>
    <dbReference type="eggNOG" id="ENOG502RSI9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1288969_0_0_1"/>
    <dbReference type="InParanoid" id="I1RHW5"/>
    <dbReference type="OrthoDB" id="5106821at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124237" evidence="2">
        <location>
            <begin position="18"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
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        </location>
    </feature>
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            <end position="106"/>
        </location>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF78175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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    </evidence>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF78389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="171" mass="19563" checksum="56895B224CD5B345" modified="2012-06-13" version="1">MEDITICIATPDEIPELVGSITKARAEMFPFLDQASSNRMAQKEHENFRKNHLDHPLGAFLTARFEGRLVATIGYVPYDGRFPFLNLEPDNVVEVVRLYVNPEWRRAGIASKLFAQLVDKAQHAGVKQLYLHTHPFLPNAIGFWEQNGFSIMSVDKDPVWQTTHMSRLLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJD3</accession>
    <accession>A0A098DLN1</accession>
    <name>I1RJD3_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG03946.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T14097</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321720.1">
        <property type="nucleotide sequence ID" value="XM_011323418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJD3"/>
    <dbReference type="FunCoup" id="I1RJD3">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RJD3"/>
    <dbReference type="EnsemblFungi" id="CEF78851">
        <property type="protein sequence ID" value="CEF78851"/>
        <property type="gene ID" value="FGRRES_03946"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03946"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14097"/>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_14_5_1"/>
    <dbReference type="InParanoid" id="I1RJD3"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="4">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="31"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF78851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="107" mass="12326" checksum="533ACD787F0AF3A6" modified="2012-06-13" version="1">MTVHVIKNLAEFRDHLEKHEVVIVDFWAPWCGPCRFISPVVERMSEQHGNDKVFFVKVDVDEAEDISQEYGIRAMPTFMVFKDGEKVGEIVGADPNKLEQMVRQFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1RK50</accession>
    <name>I1RK50_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG04238.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T14813</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
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        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        <citation type="submission" date="2017-01" db="UniProtKB">
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                <consortium name="EnsemblFungi"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1RKL4</accession>
    <name>I1RKL4_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
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        <name evidence="3" type="primary">FG04425.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T15259</name>
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    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
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    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_011322877.1"/>
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        <property type="protein sequence ID" value="CEF79430"/>
        <property type="gene ID" value="FGRRES_04425"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15259"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_001373_1_0_1"/>
    <dbReference type="InParanoid" id="I1RKL4"/>
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        <property type="component" value="Chromosome 2"/>
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        </source>
    </evidence>
    <sequence length="1367" mass="148095" checksum="19D6626AFD1769A0" modified="2012-06-13" version="1">MTLSKATISHDGQEIDEAPDASLLLSSPLSTPLTTSPELVSIQSLADQNPTPLSMMDDSCFLDIDKCISTGLEAGSVSAPASVDKTAATSNQSPSNSVELPATTKDPSTHSQHNADLPRPKETADDGNAEPTRAADDGNVPYSTGKDSNLQSILGGQSNDKSQETTQTGHSKNGASQAQPKVISPSALNTTGLSSQNSNAPSNAADPALGFRGLHSDQHEYRIDSSTRYYSQYETASAPIGPSSAGALPARGTATAPAQTSSHCTATQSATRVMSSTTSTSNNSVPPGHQRHRNDHSSHDNGFPPSHNTSLSSRSSGIKLDTSFIRPTPRTIVRTAPDSPSLNIKHPTPDITSQARSGAYVGNIAQLEATAERLSMTSSIDDAIRDLHTELKRSDSRRSSILAASLKASGSIDDYSNNPGSAVEQLRRHPSIASSIVSTNNAARHGGYSPAGYVLSPNHSFTGRLRSGSKNSAGRPDFDLDTVLSRHGPGKASVRSVRSTKVSLAEISESEPIALTQDVLDMADKAPAKNPEGDSLLPEELRDANMPATDVFQNMMGDDDFMDATKKRPANTGHQESRDPQRPGSSHSDTTFQQCQDAFGDFDGVHWVPDQDDPYAPPNDGEPQPQHQAAHRPAPRPDIRPQSYMDPESGQQMLYYPARVPAMLNLPPKLSNKPKANERNKRRSQVMSAMFDGGRKSQVMDAPAPERDTTRDSWLPDPLAGHRASFVALTSDELRELGQQPDPARSVHSEHDAAPAVQPEPTADSSVETLRRPQKLSKKNPDDRNTRMSNLPPQLRASAYFDLPDNTQPDIEVKDGSAMATLESILDASANAPVSAFTDHERAGRLGKEVYGKEKKRASVAPSAALQPEPDKKHARKRSSFLWLGKRHSHVSDDNKDQKAQSESGLGPVNADTNAAEHDGLARSVDGRGDGHSDDEQGAKDDDSDASVEEEGYHGPPTTLLAELQLRKQQQKERTQRTFPGGMHATLLEMDAVAETQKKARNTKRINLAWEEGQAQPVDENSDDEDIPLAVIAARNQGAKNVMDLNRPIGLMERREMEENEPLSHRRARLHGQDPRSMVITNRPSMNNLSANYLPTTPHSVAPHSVQNASPEPDDEFEGETLADRKKRLAAKEEAENLLPKARAVSGAFSIELLNQFEDPEKKKKEEEESKPKSGEEETLGQRRRRLQAEREAREREMSFNQLNASTEEPPVPVPGVNGHMHQMSSVLSAHPKRSVNEAMAERERLERERRLVREGDARMAAYRNQMPQALGQAGNASSGGYRGGTFNNGLGGQNSQAAMSSPALHTQIFNQPALSHRKSAVFNTYGTPMQPGMSVYGGNMMQPGMQMPGQAGPTNRIEQWRQGVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1RLL1</accession>
    <name>I1RLL1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG04816.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T16383</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323266.1">
        <property type="nucleotide sequence ID" value="XM_011324964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RLL1"/>
    <dbReference type="EnsemblFungi" id="CEF88565">
        <property type="protein sequence ID" value="CEF88565"/>
        <property type="gene ID" value="FGRRES_04816"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04816"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16383"/>
    <dbReference type="eggNOG" id="ENOG502RQIG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076930_0_0_1"/>
    <dbReference type="InParanoid" id="I1RLL1"/>
    <dbReference type="OrthoDB" id="5103882at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124381" evidence="1">
        <location>
            <begin position="21"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF88565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="358" mass="37023" checksum="6B83E628C97F839B" modified="2012-06-13" version="1">MRFVSFATVLGAALLPAVNARPACRPDTSATSGVSATSVATTTAAAVETSSTEAATTVDASTTYETTTALETTVVVSATDETTTALETTVAISETATSDSTALIPTTTAETPAETTTAETTVAEIVTNSAETTIAEIATTTAETTLAEITTTTAETTAVEIVTTAAETTPAEIATTTAETTPAEVVTTTTEAATTTTAEAAGPTNFVKNGGFEDNTSNAWTLLNSDIANNPGNAHTGGQYLEFYVNNDFANGQNQASQTISGLSTDRQYGFSFYASVFGTPEPVIIPSTLCHIQARQGGAVIAQFPLDLNSVDYYDIYKVNFTPLSSDIDLSLRLRCTNGRRVTLALGIDDVAIGDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1RMB0</accession>
    <name>I1RMB0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T17093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323591.1">
        <property type="nucleotide sequence ID" value="XM_011325289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RMB0"/>
    <dbReference type="KEGG" id="fgr:FGSG_05097"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17093"/>
    <dbReference type="eggNOG" id="ENOG502T64E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107684_1_0_1"/>
    <dbReference type="InParanoid" id="I1RMB0"/>
    <dbReference type="OrthoDB" id="4848529at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="152" mass="16706" checksum="4AF7FBE4BA4B17D2" modified="2012-06-13" version="1">MSDSSTPKTNAWTEEAKNELLLRIIAQLKPEGKSINWNEISMEGRTMKSLQNQWTAVNKKIDAIKQQTADAPPPPAKKTPVRKRATKPKTSKTVGSDEDDGDYGSPKKVTPRKRRAPKAGVDDESPESSAKAIKMELNETIKAEGGGLDYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>I1RME9</accession>
    <name>I1RME9_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor CWC2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pre-mRNA-splicing factor cwc2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">FG05138.1</name>
        <name evidence="20" type="ORF">FGRAMPH1_01T17191</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="21">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="22">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="21">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="20 22" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="20">PH-1</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323637.1">
        <property type="nucleotide sequence ID" value="XM_011325335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RME9"/>
    <dbReference type="FunCoup" id="I1RME9">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RME9"/>
    <dbReference type="EnsemblFungi" id="CEF88754">
        <property type="protein sequence ID" value="CEF88754"/>
        <property type="gene ID" value="FGRRES_05138"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05138"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17191"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043308_1_0_1"/>
    <dbReference type="InParanoid" id="I1RME9"/>
    <dbReference type="OrthoDB" id="10251848at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000249">
        <property type="entry name" value="Pre-mRNA-splicing factor CWC2, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="174"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CEF88754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="398" mass="44216" checksum="7C52DE0D86601376" modified="2012-06-13" version="1">MADTAEQVEMAPVAEQENQEMAVATTNNEVAAPTGKKVVKKIIRKKKRPARAQVDPDFFTTEPPPQTGTIFNIWYNKWSGGDREDKYLSKTKAKSRCNVSKDSGYTKADTIPGSFFCLRFARGICPKGQDCDFLHRLPGTYDHFNPNVDCFGRDKFSDYRDDMGGVGSFMRQNRTVYAGRIHVTDDIEEIVARHFAEWGPVERIRVLNTRGVAFVTYVNQANAEFAKEAMAHQSLDHDEVLNVRWATADPNPMAQAREARKIEEQAADAIRRALPAEFVAEIEGRDPEARKRRKIESSYGLEGYEAPDEIHFARGAQSVNPLGREGFEVEYQERPMIENGEAGQAQAEEQQPQQETGGIFSGSTLAALNKAKVAVASKPKAAASAGPLVAYDSDSDDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-06-20" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>I1RN14</accession>
    <accession>A0A098DYP3</accession>
    <accession>A0A1C3YK55</accession>
    <name>NPS2_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nonribosomal peptide synthetase 2</fullName>
            <shortName evidence="9">NPRS 2</shortName>
            <ecNumber evidence="12">6.3.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Ferricrocin synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Intracellular siderophore synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NPS2</name>
        <name type="ORF">FG05372</name>
        <name type="ORF">FGRAMPH1_01T17751</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="Plant Cell" volume="18" first="2836" last="2853">
            <title>NPS6, encoding a nonribosomal peptide synthetase involved in siderophore-mediated iron metabolism, is a conserved virulence determinant of plant pathogenic ascomycetes.</title>
            <authorList>
                <person name="Oide S."/>
                <person name="Moeder W."/>
                <person name="Krasnoff S."/>
                <person name="Gibson D."/>
                <person name="Haas H."/>
                <person name="Yoshioka K."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="17056706"/>
            <dbReference type="DOI" id="10.1105/tpc.106.045633"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>INDUCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="Curr. Genet." volume="51" first="43" last="58">
            <title>Nonribosomal peptide synthetase (NPS) genes in Fusarium graminearum, F. culmorum and F. pseudograminearium and identification of NPS2 as the producer of ferricrocin.</title>
            <authorList>
                <person name="Tobiasen C."/>
                <person name="Aahman J."/>
                <person name="Ravnholt K.S."/>
                <person name="Bjerrum M.J."/>
                <person name="Grell M.N."/>
                <person name="Giese H."/>
            </authorList>
            <dbReference type="PubMed" id="17043871"/>
            <dbReference type="DOI" id="10.1007/s00294-006-0103-0"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2007" name="Eukaryot. Cell" volume="6" first="1339" last="1353">
            <title>Intracellular siderophores are essential for ascomycete sexual development in heterothallic Cochliobolus heterostrophus and homothallic Gibberella zeae.</title>
            <authorList>
                <person name="Oide S."/>
                <person name="Krasnoff S.B."/>
                <person name="Gibson D.M."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="17601875"/>
            <dbReference type="DOI" id="10.1128/EC.00111-07"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2007" name="Mol. Plant Pathol." volume="8" first="411" last="421">
            <title>The siderophore biosynthetic gene SID1, but not the ferroxidase gene FET3, is required for full Fusarium graminearum virulence.</title>
            <authorList>
                <person name="Greenshields D.L."/>
                <person name="Liu G."/>
                <person name="Feng J."/>
                <person name="Selvaraj G."/>
                <person name="Wei Y."/>
            </authorList>
            <dbReference type="PubMed" id="20507510"/>
            <dbReference type="DOI" id="10.1111/j.1364-3703.2007.00401.x"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="5 6 7 8">Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of hydroxamate-containing siderophores that play a critical role in virulence (PubMed:17043871, PubMed:17601875). Gibberella zeae produces extracellular coprogen-type siderophores as well as the intracellular siderophore ferricrocin (PubMed:17056706). The role of extracellular siderophores is to supply iron to the fungus during plant infection, and the intracellular ferricrocin is required for intracellular iron distribution and storage with a crucial role in ascus and ascospore development (PubMed:17043871, PubMed:17056706, PubMed:17601875). SID1 catalyzes the conversion of L-ornithine to N(5)-hydroxyornithine, the first step in the biosynthesis of all hydroxamate-containing siderophores (PubMed:20507510). The assembly of extracellular coprogen-type siderophores is performed by the nonribosomal peptide synthetase (NRPS) NPS6 whereas the intracellular siderophore ferricrocin is assembled by NPS2 (PubMed:17043871, PubMed:17056706, PubMed:17601875).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 7">Siderophore biosynthesis.</text>
    </comment>
    <comment type="domain">
        <text evidence="1 12">NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module (By similarity). Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product (By similarity). Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme (By similarity). Occasionally, methyltransferase domains (responsible for amino acid methylation) are present within the NRP synthetase (By similarity). NPS2 has the following architecture: A-T-C-A-T-C-A-T-C-A-T-C-T-C-T-C (PubMed:17043871).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="7">Leads to defective intracellular siderophore (ferricrocin) biosynthesis and sexual development (PubMed:17601875).</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="sequence caution" evidence="11">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="SCB64745" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="6.3.2.-" evidence="12"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64745.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323896.1">
        <property type="nucleotide sequence ID" value="XM_011325594.1"/>
    </dbReference>
    <dbReference type="SMR" id="I1RN14"/>
    <dbReference type="STRING" id="229533.I1RN14"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T17751">
        <property type="protein sequence ID" value="FGRAMPH1_01T17751-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G17751"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05372"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000092_2_0_1"/>
    <dbReference type="InParanoid" id="I1RN14"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="PHI-base" id="PHI:3658"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031169">
        <property type="term" value="P:ferrichrome biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.980:FF:000001">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000033">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000024">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000444385" description="Nonribosomal peptide synthetase 2">
        <location>
            <begin position="1"/>
            <end position="4841"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier 1" evidence="4">
        <location>
            <begin position="531"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier 2" evidence="4">
        <location>
            <begin position="1587"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier 3" evidence="4">
        <location>
            <begin position="2139"/>
            <end position="2212"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier 4" evidence="4">
        <location>
            <begin position="3219"/>
            <end position="3293"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier 5" evidence="4">
        <location>
            <begin position="3759"/>
            <end position="3838"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier 6" evidence="4">
        <location>
            <begin position="4318"/>
            <end position="4394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylation 1" evidence="2 3">
        <location>
            <begin position="26"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Condensation 1" evidence="2 3">
        <location>
            <begin position="640"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylation 2" evidence="2 3">
        <location>
            <begin position="1072"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Condensation 2" evidence="2 3">
        <location>
            <begin position="1702"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Condensation 3" evidence="2 3">
        <location>
            <begin position="2248"/>
            <end position="2663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylation 3" evidence="2 3">
        <location>
            <begin position="2695"/>
            <end position="3090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Condensation 4" evidence="2 3">
        <location>
            <begin position="3333"/>
            <end position="3735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Condensation 5" evidence="2 3">
        <location>
            <begin position="3873"/>
            <end position="4242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Condensation 6" evidence="2 3">
        <location>
            <begin position="4430"/>
            <end position="4726"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="565"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1625"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2173"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="3253"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="3799"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="4355"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="A0A144KPJ6"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q5D6D7"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="17043871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="17056706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="17601875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="20507510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="9">
        <source>
            <dbReference type="PubMed" id="17043871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="10">
        <source>
            <dbReference type="PubMed" id="17601875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="11"/>
    <evidence type="ECO:0000305" key="12">
        <source>
            <dbReference type="PubMed" id="17043871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86467"/>
        </source>
    </evidence>
    <sequence length="4841" mass="536040" checksum="390CA4A642790FDB" modified="2012-06-13" version="1">[encoded data, 4841 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1RNI7</accession>
    <name>I1RNI7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG05568.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T18223</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324119.1">
        <property type="nucleotide sequence ID" value="XM_011325817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RNI7"/>
    <dbReference type="EnsemblFungi" id="CEF87245">
        <property type="protein sequence ID" value="CEF87245"/>
        <property type="gene ID" value="FGRRES_05568"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05568"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18223"/>
    <dbReference type="eggNOG" id="ENOG502S0ES">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021647_0_0_1"/>
    <dbReference type="InParanoid" id="I1RNI7"/>
    <dbReference type="OrthoDB" id="5338458at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF1">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="183"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF87245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="592" mass="66891" checksum="CF8EEFDFF8DAA34A" modified="2012-06-13" version="1">MVKEWSREPFSRYPHHSYLPERFVGDGIDDSRFPEAQDMHRRQPPIQIDEALRQSCGISARRYFLVVVMDDGSPQTFSGPGTSGVRSGYEKQFFDMEKYLKVVDRLDAGASPVINDDVSYDSYRQSMDFPRNRMIDRRRMSQFDEWETPSRQGRKRPRARHGIADDDDIPMTVATTIRKGIKIGNSLDVGLFYELRFKNCQQTACKLMAKAWVKAVEPKKQSTHPYTGSDEKAPDWWPKPWGPTKEDKVRHKEPDHLYKRERVHLLNHILRMIVEPNQRQHPDIQKLKLNVQKLEEITIEALSGFFADKDNPANAKKRPFLNEIFKVAKQEERFKKEEIDGSTEVFVMADDKIPESYVSSNDDHGPILKEEDDHDVTPNKLTAVHGLMPSSNSHSTGTSLHGTPFLGGDLPVRGNQYTPSTMPEMPQDQHAFVENTGMPVNGQPSAHATGGSLTMDMGVPPAHDASRRASIFSAHSEYGGQNNTAMYTQQWQPGSTAPNSSSMYTFTPQPPSQPTTTFVSPGVAMNQAQSYMNTSFDGLARGYDPNQTPMFRTGSVPQPTQLHPAQGYDYMSHDNRGLPGVKVDDVPRHAMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1RNS2</accession>
    <name>I1RNS2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FGRAMPH1_01T18443</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="protein sequence ID" value="CEF87191.1"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="553"/>
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            <dbReference type="PROSITE" id="PS50850"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RP85</accession>
    <accession>A0A098DYM5</accession>
    <name>I1RP85_GIBZE</name>
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        <submittedName>
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        <name evidence="2" type="primary">FG05842.1</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_011326140.1"/>
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        <property type="protein sequence ID" value="CEF86940"/>
        <property type="gene ID" value="FGRRES_05842"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05842"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18895"/>
    <dbReference type="eggNOG" id="ENOG502RPX4">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_037155_3_0_1"/>
    <dbReference type="InParanoid" id="I1RP85"/>
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        <property type="component" value="Chromosome 3"/>
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    <dbReference type="InterPro" id="IPR025533">
        <property type="entry name" value="DUF4419"/>
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        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252:SF11">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14388">
        <property type="entry name" value="DUF4419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF86940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="445" mass="49696" checksum="A7D2A15630A7803D" modified="2012-06-13" version="1">MLLWLAGLGLVTASITIPLSPVAPLPLSHQGAATSADDLFRKSCPEEVASSNPYTASLLASSFSNDVFSAGRVFPSSGGFIRGAVEAWAQHQHLVLRPEEVWFEVLVQMNVYMSVHSEKVRGLFVEHEGEKEKIVVEGNTWDDMVVGFGDEIDKRVKTTWLKDWIMPGFSTSTPKDDVTAAVLMMGLMKQFFDFEGWVVCGIPSVTLLGTREDWVKLEAKLDYLKEFGPDPELFAEMLKPIMKRFVNSWDDAHAEDIKLFWEQIVRVKKQWSCGEGANEWDVSGWITGFDFFDRNGRRRGYDAWQAYDEDDEEEDGEEKETVKEEPQMGIFATDWSIVMDGQKYISLSLSDISTGYAKTPVKLKDYPHPGVDTEVYILAGNVGVERIEDKGKVTAQPVSGWFAYGPVNTNHTVGPFIGSAIEMESIAVGIESCKATKGEEEVKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1RPS3</accession>
    <name>I1RPS3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG06052.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T19371</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324672.1">
        <property type="nucleotide sequence ID" value="XM_011326370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RPS3"/>
    <dbReference type="FunCoup" id="I1RPS3">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RPS3"/>
    <dbReference type="EnsemblFungi" id="CEF86542">
        <property type="protein sequence ID" value="CEF86542"/>
        <property type="gene ID" value="FGRRES_06052"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06052"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19371"/>
    <dbReference type="eggNOG" id="KOG2395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007002_0_0_1"/>
    <dbReference type="InParanoid" id="I1RPS3"/>
    <dbReference type="OrthoDB" id="10251113at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040979">
        <property type="entry name" value="Vid27_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040768">
        <property type="entry name" value="Vid27_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17748">
        <property type="entry name" value="VID27_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17747">
        <property type="entry name" value="VID27_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vid27 N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Vid27 PH-like" evidence="3">
        <location>
            <begin position="248"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="428"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF86542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="813" mass="91785" checksum="39209DBD22CD3B5B" modified="2012-06-13" version="1">MFALRGIGKLIFGSSAQETLIELPQGQLYLVRPLSPKGYSELIFRDSAIRIRRTNQEFQYQLVVQRVFEEGEAELLAEEEGEDAEIDALASEKDEKTFLLDEALCFRFEIRETGDKVLAWKDLSGDTGDLFQFVCDSTVTSAQVQQFVRVAQECQYERKYRKSNSTATEADLQQFEFEEEDPIPPASPLHSPTLARSIESVDDMLSKNAANSAAKRAPEVIPEVVPEQEIEPQVLTGPDANNPPEAIEIYAAVTAELHVFDPQPGHFALVDDSIIAQVSEVGKWEYWLQIESGDKAYLGTPVVADFNPVFDFEYLSFVFNHFSSDGTARSWLLRFKDQSTLEKFQEAIMQAIWERLNETKWQKMQDKEREYVLDAFGDLTMEDAPETEEEEEEEEEEEELEDDRARDEEYDSDEENDSTFPKNADGEVNSQLAVGYKHDRSFVVRGSKIGVFKHTPNNHLEFSTNISKVTTPSGKLMNPKKVMLHSEDRDLILQNEIDPNKLYRMDLEYGKVVDEWHVHDDIPVVTFAPENKFAQMTSEQTFLGVSNNALYRVDPRLSGNKLVDADMKQYASKNDFSALATTEKGYIAVASNKGDIRLFDRLGIRAKTQLPALGDPISGIDVSADGRWILGTTKNYILLVDAQQKSGKNEGKLGFEKAFAATDKPHPRRLALTPEHVAQFYHETGKPVDFTPAKFNTGEGAEETSIITATGPYIIEWNLKRILRGMKASYKIKRYEEEVKADDFKFGSDKNVIVALPNEVNMVAKQSLKKPTRESIVGNIRLGGGSRRDSGRIGNQESGRYKLGRDDIVNAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I1RRB6</accession>
    <name>I1RRB6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG06634.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T22789</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326257.1">
        <property type="nucleotide sequence ID" value="XM_011327955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RRB6"/>
    <dbReference type="EnsemblFungi" id="CEF84025">
        <property type="protein sequence ID" value="CEF84025"/>
        <property type="gene ID" value="FGRRES_06634"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06634"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22789"/>
    <dbReference type="eggNOG" id="ENOG502S020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059021_3_0_1"/>
    <dbReference type="InParanoid" id="I1RRB6"/>
    <dbReference type="OrthoDB" id="10250990at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="5">
        <location>
            <begin position="77"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF84025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="286" mass="31631" checksum="779137C477EF73CE" modified="2012-06-13" version="1">MGDNIKRNPHPDFKGVEASRPEFDTASQFRYTKTVDADWAFGEGANKLGKDADKKHVTIDPHEEGRPAGFNYKFLISSIVPRPIAFVSSQAPDGTHKNLAPFSYFNMMAHDPPMFVVGFSSSLEAAKDSLRNVVDSGECVINIISEHFVEAANSCSVNAPYGVSEWDISGLTPSYDCETVKCARVREAIVSIECKLDMIKEFDSKARPGNKSGVMAVFEGTRFWVREDALNEEKNLVDPGVLRPISRLGGITYGRVTEAFELVRTDYEKDVGGEAGVEKIQKEHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RRP2</accession>
    <accession>A0A098DNP3</accession>
    <name>I1RRP2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG06775.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T23157</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF82972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326425.1">
        <property type="nucleotide sequence ID" value="XM_011328123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RRP2"/>
    <dbReference type="EnsemblFungi" id="CEF82972">
        <property type="protein sequence ID" value="CEF82972"/>
        <property type="gene ID" value="FGRRES_06775"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06775"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23157"/>
    <dbReference type="eggNOG" id="ENOG502SI3Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014722_5_2_1"/>
    <dbReference type="InParanoid" id="I1RRP2"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF11">
        <property type="entry name" value="WSC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124477" evidence="2">
        <location>
            <begin position="19"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="41"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF82972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF82972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="525" mass="56989" checksum="AF9EC1991095B775" modified="2012-06-13" version="1">MKSTFVAAAALLAGAASAAKDEGTFAVLRFTNKQLTRGRMDPILFPGETSTHVHNIMGGSGFSTSATGKDLMESKCSNAMIKGDNSAYWFPSLYFQDPKSGKFEDVEFDYFNAYYFFEKTHDEIKPFPAGLQIVAGDAMTRTMPKAGAKPNLDPSKGPVNAARMTCPRANNDYTVPSWDAKSDGTTAGVGDPITKNEGVGFPDRTCDGTFSPLRADVHFPSCYNPEAGLTDFKNNMAYPEDNDGYLDCPKGWIHVPHLFYEAYWNTNKFQGRWTEGEGKQPFVFSNGDVTGYSSHADFMAGWDEKLLKHIIDTCNAGTLGMDNCPGLFYGLNKDDCTIESEIDEKTTGKLDKLPGNNPLSGFSYGDAPSMPNKGDDDEKPSKPSAEPSVKPSATNSAPEDKSTAVEAPQYTKPADKPEEPTVAIPKPTVPIVSGVVSDAAAEATSALTNAPKPTEIFGKPDQPKKCKSTRVHTVWNTVTVTQTASVPAQTEDAAAAPAYKRDHVRRHAHQHGSGYSHVRRRSHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>I1RRY3</accession>
    <name>I1RRY3_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG06886.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T23417</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326548.1">
        <property type="nucleotide sequence ID" value="XM_011328246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RRY3"/>
    <dbReference type="SMR" id="I1RRY3"/>
    <dbReference type="FunCoup" id="I1RRY3">
        <property type="interactions" value="616"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RRY3"/>
    <dbReference type="EnsemblFungi" id="CEF83010">
        <property type="protein sequence ID" value="CEF83010"/>
        <property type="gene ID" value="FGRRES_06886"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06886"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23417"/>
    <dbReference type="eggNOG" id="KOG0175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_7_1_1"/>
    <dbReference type="InParanoid" id="I1RRY3"/>
    <dbReference type="OrthoDB" id="37597at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080129">
        <property type="term" value="P:proteasome core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000013">
        <property type="entry name" value="Proteasome subunit beta type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF83010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="283" mass="31090" checksum="7157678CF570C586" modified="2012-06-13" version="1">MNSLVSQYSRSSYEQNEPLDEQDELLNSMGGDLSIKFAMPPVAQPSSWLRAATDDRSNPNCPIKIAHGTTTLAFRFQGGIIVATDSRATAGNWIASQTVKKVIEINSVLLGTMAGGAADCQYWLAWLGMQCRLHELRHKRRISVAAASKILANLVYSYKGMGLSMGTMCAGVTKEEGPALYYVDSDGTRLAGNLFCVGSGQTFAYGVLDAEYKYELSDEEALELGKRSILAATHRDAYSGGYINLYHVKEEGWVKHGFNDTNPIFWKTKLEKGEFTNVTSKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1RTN1</accession>
    <name>I1RTN1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG07542.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T25059</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Alpha-L-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose. Acts only on small linear 1,5-alpha-linked L-arabinofuranosyl oligosaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327320.1">
        <property type="nucleotide sequence ID" value="XM_011329018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RTN1"/>
    <dbReference type="STRING" id="229533.I1RTN1"/>
    <dbReference type="EnsemblFungi" id="CEF84726">
        <property type="protein sequence ID" value="CEF84726"/>
        <property type="gene ID" value="FGRRES_07542"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07542"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25059"/>
    <dbReference type="eggNOG" id="ENOG502QRW4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017810_1_0_1"/>
    <dbReference type="InParanoid" id="I1RTN1"/>
    <dbReference type="OrthoDB" id="3032304at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576:SF3">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="9">
        <location>
            <begin position="309"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF84726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="506" mass="56827" checksum="30DAD6045E0E22EC" modified="2012-06-13" version="1">MATFTRIADDERPTISVDPSAVISTIDDNIYGGFTEHMGRCIYGGIYEPGNPLSDENGFRKDVIEAMKELNCPVVRYPGGNFVATYHWQDGIGPREKRPVRPELAWIGTESNEFGTDEFMKWCEVVGTEPYLCLNFGTGTLDEALAWVEYCNSDRPSYYANLRRQNGREKPYNVKYWALGNEMWGAWQVGQMTKEDYAKKAYQWAKAIKLLDPSVTLILCGETGHSTWDSYVIKECIKFDVHGLGGSTTASLIDQHSIHIYTASSDHYKNATAPRSAERAIEIASGLIDLARIENGVPPTVPRQKICFDEWNVWDPERAPGEEGAEEKYNLSDALAVAIWLNVFIRQSKHVGMANIAQSVNVISPLMTTKDGLLKQPTWWPLLLYSKYMRGSTIAVNLRGGEYLGETHPQWIRGTIETPWLDVSAALDKDGTVNLAVVNIHEDKDFETELKGLGGKEVEVHSVSGTDVKVVNTAEKEEVGIKESKWNGEGLFKFPKHSFTLLRWKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1RU55</accession>
    <accession>A0A098DM45</accession>
    <name>I1RU55_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG07737.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T25527</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF82950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327546.1">
        <property type="nucleotide sequence ID" value="XM_011329244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RU55"/>
    <dbReference type="STRING" id="229533.I1RU55"/>
    <dbReference type="EnsemblFungi" id="CEF82950">
        <property type="protein sequence ID" value="CEF82950"/>
        <property type="gene ID" value="FGRRES_07737"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07737"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25527"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015777_0_0_1"/>
    <dbReference type="InParanoid" id="I1RU55"/>
    <dbReference type="OrthoDB" id="4588414at2759"/>
    <dbReference type="PHI-base" id="PHI:1391"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="322"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF82950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF82950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="739" mass="82990" checksum="E739D812FC5FE457" modified="2012-06-13" version="1">MSRLFGFLNLSRRLYVITYPIYNDACLTVVNIKVMKAQYLLDGTKIPFELSSPNTTLPENTEPFDTEASEDDSPWEISDDSNDSGCEADSPQDMHRNDHSQNYNRNSNERSTTEMGQVLKSTKLIIECLYKLPLRNPTPIDRIKRFRDPDTSPYEAFDVMHVREKFPNADAYLVDRLGKLISHRRQLLEHRVTQTEELRLPTFPKGTFQSPAEGARNLQELDHAPVTESKLATESEDTEEHELEVPTRPVNESGEPLVQFYCPYCGLAQCIPLEPSRDWESHVLRDLQPYVCTFQDCDMFDHMFESRQAWFTHELELHRANWSCNTCPSEPGMDSPHLTFGNKGAFMSHMSSVHQLSKPRLNNLTGAFRHPSSKVDRYCCLCGKHVQKLELHLGRHMEDVALFALQQLSLPDPSNLGNSTKAVIDQFHGSSRNLPSKSNPENRSGAGHATGNDTAGHANATSSPFIAVAAWRSGVVKPRNPDPSSDRGLTGIANARNSDTFPNTVWDMLPSDALSILVRNVESIMSVTRTEPAPSAPTSTILPLSLLALEKAETYRDFTIPESSTKGRTIPGRFIQGSSRGLKDEDYGESVSPSYPVTERVLGTEPTDSIALPKLQQQRAMLRKFYSKNIPPITIKIYLERLYQFCPMSTAVYLATSLRLRRLAVEQQVVTINAFTAYRLVLAGLLVQAKALEDVQYPHAKLAKVGGSHYDSFMNKTKTRVVEDLDKGKVTQRGIVEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1RUG7</accession>
    <name>I1RUG7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">FG07860.1</name>
        <name evidence="14" type="ORF">FGRAMPH1_01T25837</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327688.1">
        <property type="nucleotide sequence ID" value="XM_011329386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RUG7"/>
    <dbReference type="EnsemblFungi" id="CEF84622">
        <property type="protein sequence ID" value="CEF84622"/>
        <property type="gene ID" value="FGRRES_07860"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07860"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25837"/>
    <dbReference type="eggNOG" id="KOG4505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008635_5_1_1"/>
    <dbReference type="InParanoid" id="I1RUG7"/>
    <dbReference type="OrthoDB" id="5327978at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF1">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="267"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="32"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="506"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CEF84622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="535" mass="58948" checksum="F0107616EE4E5ECC" modified="2012-06-13" version="1">MAYSIWEIPLQTTNFNIVVAVLGGFISLFGLVSYLLKENYYLSEALISLLAGVAFGPNGANFIRPEDYASCNVLSREACETDLSAITLNFSRLVLGVQLVLAGVQLPSKYLVKEWKSISLLLGPGMTSMWLATSVLVWALAGQPPFLHALAIGSCVTPTDPVLSAVIVKGKFADHNIPQDLQYLITAESGANDGLGYPFLFLALYLIKFTGAGATSGGAGDAMGLWFGMTWGYTIILSVIYGAVVGWVGKEMLHFAEKRNYVDRESFLVFAIALALFVLGTCGMVGTDDVLACFIAGNVFTWDDWFRLETKDDSLQPTIDMLLNVTIFLWYGAYIPWSDFNTTTVISIERLVALGICVLLLRRLPWVFAMHKWIRQIEEVKQAVFVGFFGPIGVSAIFYLFITVEFIETHLSDEDGRPRSDVKDLAEQTRIIVWFLTVCSIIVHGLSIPVGKLGYFVPRTLSQAVSDSVINAPDDSLRRRIPFVGKYFGRNNDRRPSGPIVITGGRSLRAEPHAPAHAGDETPPVRREIRFGDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RUT8</accession>
    <accession>A0A098DE55</accession>
    <name>I1RUT8_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="11">3.2.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FGRAMPH1_01T08857</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="11"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320841.1">
        <property type="nucleotide sequence ID" value="XM_011322539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RUT8"/>
    <dbReference type="STRING" id="229533.I1RUT8"/>
    <dbReference type="EnsemblFungi" id="CEF76231">
        <property type="protein sequence ID" value="CEF76231"/>
        <property type="gene ID" value="FGRRES_07993"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07993"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08857"/>
    <dbReference type="eggNOG" id="ENOG502SHDC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_5_3_1"/>
    <dbReference type="InParanoid" id="I1RUT8"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124553" description="xylan 1,4-beta-xylosidase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="13">
        <location>
            <begin position="671"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CEF76231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="766" mass="84775" checksum="00FA735425ECFF05" modified="2012-06-13" version="1">MMLHKLQVAASALALLNGLALAAAPYQQPDCTKEPLRSNGICDTTASPAERAAALVSALTPREKVNNLVSNATGAPRIGLPRYNWWNEALHGVAGAPGNDYNDKPPYDSATSFPMPLLMGSTFDDDLIHDIGEVIGTEARAWNNGGWGGGVDYWTPNVNPFKDPRWGRGSETPGEDALHVSRYARAMVRGLEGDKKQRRIVATCKHYAGNDFENWGGQTRHNFNAKITPQDLAEYYVRPFQECTRDAKVGSIMCSYNAVNGIPACANSYLQETLLRKHWNWTHTNNWITSDCGAMQDIWQHHNYTKTGAEAAKAAFENGQDSSCEYTTTKDISDSYEQGLLTEKVMDRALKRLFEGLVHTGFFDGDKSEWSSLDFDDVNTRHAQDLALQSAVRGAVLLKNDNTLPLNIKKKESVALIGFWADDKTKLQGGYSGPAPHVRTPAYAAKMLGLNTNVAWGPTLQNSSVPDNWTTNALEAAKKSDYIVYLGGLDATAAGEERDRTDLDWPSTQLTLLKKLSNLGKPLVVVQLGDQVDDTPLLKNKGVNSILWVNYPGQEGGTAVMELITGRKGPAGRLPLTQYPSKYTEQVGMLEMELRPTKSSPGRTYRWYSDSVLPFGFGKHYTTFKAMFKSQKIEMNIQKILKGCDATYVDTCPLPPIHLSVKNTGRTTSDFVSLVFIQGKVGPKPYPLKTLAAYSRSHDIKPRATKDVELQWTMDNIARREKNGDLVVYPGTYTLLLDEPTQVKIKVKLTGDKVVLDRWPEFHGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1RV64</accession>
    <accession>A0A098DBU2</accession>
    <name>I1RV64_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG08127.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T09181</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320689.1">
        <property type="nucleotide sequence ID" value="XM_011322387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RV64"/>
    <dbReference type="STRING" id="229533.I1RV64"/>
    <dbReference type="EnsemblFungi" id="CEF76393">
        <property type="protein sequence ID" value="CEF76393"/>
        <property type="gene ID" value="FGRRES_08127"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08127"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09181"/>
    <dbReference type="eggNOG" id="ENOG502QZAU">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_040328_0_0_1"/>
    <dbReference type="InParanoid" id="I1RV64"/>
    <dbReference type="OrthoDB" id="4088536at2759"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="I/LWEQ domain"/>
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        <property type="entry name" value="GCIP-like"/>
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        <property type="entry name" value="GCIP-like_N"/>
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    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
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    </dbReference>
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    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="2">
        <location>
            <begin position="59"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="185"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF76393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="363" mass="39943" checksum="2FCA57B291E10860" modified="2012-06-13" version="1">MAPTEEEARKALETLITTASTLLEQLQSILTSIQRSPTTPSASSTETTDIDALALARDCSSLIRAHGTKISLLIINEPFTPSALTTVVRELVKGPIPGLASAAQACETKLYTSVVRKELAYRAQKVLAELLNLLNRVPKDGKVLAGVGRDSGSGSLALTGMLWSACDEVVALANMGVGGFFVKKAEEWRDTLKDVMEELKEWGEEEDDDEDEVDDLADKMNDASLSNQEMLDEIMNSSSAIPRSDPDKIRPRLDSTLKRLRMVVLLYQALSKRRFKKLPKDTTKGDMPAKLDTTANVLAALPDKFGDLAEAFYELDGEEIDNLMEECFESAVGVSEVLKIGWEGESDEFSEWMEKFKVEVKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I1RVL2</accession>
    <accession>A0A098DDR3</accession>
    <name>I1RVL2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG08293.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T09585</name>
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    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320500.1">
        <property type="nucleotide sequence ID" value="XM_011322198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RVL2"/>
    <dbReference type="EnsemblFungi" id="CEF76595">
        <property type="protein sequence ID" value="CEF76595"/>
        <property type="gene ID" value="FGRRES_08293"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08293"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09585"/>
    <dbReference type="HOGENOM" id="CLU_1602872_0_0_1"/>
    <dbReference type="InParanoid" id="I1RVL2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF76595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="166" mass="18937" checksum="6EBB1FB8480C04A7" modified="2012-06-13" version="1">MAPWKLQTRTHNLHSQPGLDFPGHSSFLVNGRLPLIEDEEDCVFYLENTGIALVMMAKNITPLYRVLQRVQHTIHTPGGLDKGLDKLPGPKTGTTTDYLVFEVMDDHKSHMLGLGFLNQATGDNIDRRGQMRHMDVFRRTTSLSAVPLYYKSREVLYGIWCEEAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1RVP8</accession>
    <accession>A0A098DCI4</accession>
    <name>I1RVP8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG08332.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T09681</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320457.1">
        <property type="nucleotide sequence ID" value="XM_011322155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RVP8"/>
    <dbReference type="EnsemblFungi" id="CEF76643">
        <property type="protein sequence ID" value="CEF76643"/>
        <property type="gene ID" value="FGRRES_08332"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08332"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09681"/>
    <dbReference type="HOGENOM" id="CLU_644121_0_0_1"/>
    <dbReference type="InParanoid" id="I1RVP8"/>
    <dbReference type="OrthoDB" id="5087858at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124533" evidence="7">
        <location>
            <begin position="18"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="358"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF76643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="431" mass="47111" checksum="DCE0C3E6B1EB1DED" modified="2012-06-13" version="1">MLGRSLVVVAMAALSSASYIVRPRPDPDTYRYLHSEEGPLPKPELDDSRIVRALTVPYVPVQDPTPVIVPDPTWNKEYTFSWYRPRQTVAPEWSTRLRHPAASATTTDEPALPLKMTEEIVSIPTTVIITKPTGPPVWRTLPDPEESIPVPWATTSTTLPEPTLTSSTVPESTAVLEPTASLDPTATLEPTETSVPKGKSSDAAGPIIAGIIGAMVFVGILILLAWLLYRRYKRNQANKRPTIVHPFRRNLPPVPAPRAPQTPTPAPQAMHRQSQSYFLPDTPSDRQSTFTREWTGALRAWMRVPGRSRQDDSTSVVSRPANVYTGRPVGIPHPATTASTRPGGNPDFPPMTALRPQHISDWSPRSPVARKPVPSVGTTPRSAASSYLALSPYTTQSGRNWRPSQYSESVYSQPGPGVRPDSGCPLGGSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RY41</accession>
    <accession>A0A098DNA9</accession>
    <name>I1RY41_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG09272.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T27507</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF82837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328496.1">
        <property type="nucleotide sequence ID" value="XM_011330194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RY41"/>
    <dbReference type="EnsemblFungi" id="CEF82837">
        <property type="protein sequence ID" value="CEF82837"/>
        <property type="gene ID" value="FGRRES_09272"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09272"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27507"/>
    <dbReference type="eggNOG" id="ENOG502QPZ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039534_1_1_1"/>
    <dbReference type="InParanoid" id="I1RY41"/>
    <dbReference type="OrthoDB" id="507128at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054539">
        <property type="entry name" value="Beta-prop_PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22807">
        <property type="entry name" value="TrAA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124619" evidence="2">
        <location>
            <begin position="24"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller" evidence="3">
        <location>
            <begin position="38"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF82837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF82837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="485" mass="52963" checksum="86FE2DC1E1C4DDE7" modified="2012-06-13" version="1">MAPILRVTATTLASTLLFSLSSAQDCSFKTLKTSYPSPVAAKNWSYGLIANELRRPRGILFDSEGALIVIDSGNGILHFELEDGGGTCLQVTKKTTLLKQDNLNHGLAISKDGRTLYASSSNDVFAWSYDPSKVTIDNSTVQTLVTNMANSGHTSRTLLISDKDPDMLLVSRGSAGNDDRGAEDQETGRSQIRAFNISSAIESYGEPYDYLDGLRLGWGLRNSVGLAEHPETGGIFSVENSADELHRNGVDIHKDNPAEEMNFHGYLNGSREDQGGNYGYPHCYTLWSTEDFPNRGDLKVGDQFPADRQSRQSKSDTNPTDKECNTDYVPPVLAFQAHTAPLDMKFDNDGKNAYVSFHGSWNREPPVGYQISEIPFEDGRPANSSRSRDAATPIIYNEKLSSCPDDCFRPVGLAWDTQGRLWFSSDKTGEIFVLNHNKDDSSQDGSSKGDSDDDDDNDNSAFSLRPGSAALIVTMAAVIMGGFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1RYD3</accession>
    <accession>A0A098DQM3</accession>
    <name>I1RYD3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG09378.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T27231</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_011328367.1">
        <property type="nucleotide sequence ID" value="XM_011330065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RYD3"/>
    <dbReference type="STRING" id="229533.I1RYD3"/>
    <dbReference type="EnsemblFungi" id="CEF84150">
        <property type="protein sequence ID" value="CEF84150"/>
        <property type="gene ID" value="FGRRES_09378"/>
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    <dbReference type="KEGG" id="fgr:FGSG_09378"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27231"/>
    <dbReference type="eggNOG" id="KOG0536">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_046313_0_1_1"/>
    <dbReference type="InParanoid" id="I1RYD3"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
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        <property type="term" value="F:heme binding"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
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        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
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        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
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    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
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    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
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        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
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    </dbReference>
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        <property type="entry name" value="CYTOCHROME_B5_2"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124590" evidence="5">
        <location>
            <begin position="26"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="296"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
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            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
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            <begin position="145"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF84150.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF84150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="388" mass="41050" checksum="621A98A35AD85C7D" modified="2012-06-13" version="1">MGYIGISLIVASVVWVIVRPPSWMPEPLQVLLRWRGSGPPAITAKDKAKAEAEHDSDPGPSIMVSDHEVEPGPRLRARPADNRTTQDVNQGKPTIPATSTSSSLKAAKGDVSSMLPPPLPKVAPSPPTIAEPEEEQTTPKAVASNPPSISVPSFSLDNAPIAPSSHPAPRRSPTAPGPASSLGLPTARQPSMMPPPPPPGRLPPPTSTANPPVSRMPTLSQFPAMNSPQRARGPVPNRGPPSSSLGGGLAPPPTHSAKPNKPSRKVLLTPGHSPLDWARISGPNADLRGVEPSTPYLRVTPSMLKRMTGRKGKDAWMALNGKVYNVTPYADFHPGGIPELMRGAGRDATKIYGEVHPWVNYETMLSACLVGLLVEESEGAENQMDQMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RYI1</accession>
    <name>I1RYI1_GIBZE</name>
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        <recommendedName>
            <fullName evidence="5">DASH complex subunit SPC19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Outer kinetochore protein SPC19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">FG09434.1</name>
        <name evidence="14" type="ORF">FGRAMPH1_01T27103</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC19 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328303.1">
        <property type="nucleotide sequence ID" value="XM_011330001.1"/>
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    <dbReference type="STRING" id="229533.I1RYI1"/>
    <dbReference type="EnsemblFungi" id="CEF85188">
        <property type="protein sequence ID" value="CEF85188"/>
        <property type="gene ID" value="FGRRES_09434"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27103"/>
    <dbReference type="eggNOG" id="ENOG502SDEQ">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112993_0_0_1"/>
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    <dbReference type="OrthoDB" id="3361333at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="C:spindle microtubule"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DASH_Spc19"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
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    <dbReference type="Pfam" id="PF08287">
        <property type="entry name" value="DASH_Spc19"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
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    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="8" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032583"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CEF85188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="171" mass="19675" checksum="25F6FB7E27DF5161" modified="2012-06-13" version="1">MAANLSTYSDCVSSLRTSLKFLESSVETLDNGVSDFPRLVNVLKTVRHYELIPQPTLTAAESSLRDEIGPYIALLLARADSQIERQERRIETLKARAELQQGRLSRPDDNYDEFGGKSKKQKTGSRKLTTEEKLRARAVRQRKEALRYGVERLELEVLQKERELRKRLEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1RYI3</accession>
    <name>I1RYI3_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="3" type="primary">FG09436.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T27099</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328301.1">
        <property type="nucleotide sequence ID" value="XM_011329999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RYI3"/>
    <dbReference type="STRING" id="229533.I1RYI3"/>
    <dbReference type="EnsemblFungi" id="CEF85177">
        <property type="protein sequence ID" value="CEF85177"/>
        <property type="gene ID" value="FGRRES_09436"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09436"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27099"/>
    <dbReference type="eggNOG" id="ENOG502S5XV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091042_0_0_1"/>
    <dbReference type="InParanoid" id="I1RYI3"/>
    <dbReference type="OrthoDB" id="5403729at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061640">
        <property type="term" value="P:cytoskeleton-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009991">
        <property type="entry name" value="DCTN3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07426">
        <property type="entry name" value="Dynactin_p22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF85177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="203" mass="22742" checksum="D3D6718CBE2B71A2" modified="2012-06-13" version="1">MATTMDETTLSTLDLLQSRLLRVEHLLYGQSQSPALAQDRSATDQIGQLERRFSKLLYDFRDYHELMKIYRANPDFFHAPEPSEPPSQLDIDALQSIVLSSASAFPATLSSLTAIKDSPIPDPADSAALVALQDRMRAIEATQTAQAAEIADLRQRSESAVRAWYETGVLSNSKAMADIESRVEFVERQVRRAEREQEAEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZL6</accession>
    <name>I1RZL6_GIBZE</name>
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        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">FG09865.1</name>
        <name evidence="16" type="ORF">FGRAMPH1_01T06711</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
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    <reference evidence="16 18" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
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        <property type="protein sequence ID" value="CEF75160.1"/>
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    <sequence length="314" mass="34515" checksum="3685A014C4AA7B7A" modified="2012-06-13" version="1">MSTFRESISQPVVAAFCAGGVAGAVSRTVVSPLERLKILMQVQSVGRDAYKLSVGKALVKMWKEEGWRGFMRGNGTNCIRIVPYSAVQFSSYNFYKRSIFESHPGADLSPLTRLVCGGLAGITSVFLTYPLDIVRTRLSIQSASFAELGAKPKKLPGMWTTLMQMYKTEGGMSALYRGIVPTVAGVAPYVGLNFMVYESVRKYLTPEGEQNPSATRKLLAGAISGAVAQTCTYPFDVLRRRFQINTMSGMGYRYKGITDAVRVIVMQEGIKGLYKGIVPNLLKVAPSMASSWLSFEMTRDFLVDLRPDPEPQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZU9</accession>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
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    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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    <dbReference type="EnsemblFungi" id="CEF75262">
        <property type="protein sequence ID" value="CEF75262"/>
        <property type="gene ID" value="FGRRES_09954"/>
    </dbReference>
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        <property type="component" value="Chromosome 1"/>
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        <property type="entry name" value="zf-C2H2_AHC1-like"/>
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            <begin position="35"/>
            <end position="44"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF75262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="626" mass="68087" checksum="2E6946547935E7E3" modified="2012-06-13" version="1">MFRFFTSESRGSEKTPQAPQQIAELIKPLQPRSLPKTTTIASPSTQPPKRRRLSIDGPDGPSDIYAPAKRIKTEAPVGIDTLATCDAMAHSSPAVSSLENARDEIRHQFGLEILLKHDELRLINQELAKCQVALEQLRRCHLIPYPLNCPTPEQMLNVSAGKGPAVQSRPGESVPRWAPPFGVVDGPYARHYAKWLIPDPSFDGQQPEWQFTPEASRARMSHAEGRTTRNSFAEPTGALKGRSARGATSQKLHSLSNGYPQPKDKAGPCVLKRADGQTVKLVCLDCHRDNFSSTQGFINHCRIAHKRDFKSHEEAAVHSGHPIEVVEGGGVEEKSAAPSVQTQTAAFVHPFARPDITEQQAYVALRSRISDSLRLYYEGKLPGITRIPSSSDKDQQRGAQTVVSADEAPGLPHLSRLLQSRKFDGNLRELVADATTRSPLEDMTSGEESELAETPSEVSDVKGSSAVRTPIVMRVPAKATNSPSVMDTARSASSKGRAPVAFKTPSGSAPHGTTIVLSDEDLDMEDADMSPNTMVSNNAPSLVSDDGEYDDTDDGSSVSGASDTLETESVSDVAEITLDDDQDPRSLRRESSGVSGAVRLRKDDPKHITLMTPVKNNARERRPRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1S0H8</accession>
    <name>I1S0H8_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="3" type="primary">FG10206.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T07541</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319153.1">
        <property type="nucleotide sequence ID" value="XM_011320851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S0H8"/>
    <dbReference type="EnsemblFungi" id="CEF75574">
        <property type="protein sequence ID" value="CEF75574"/>
        <property type="gene ID" value="FGRRES_10206"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10206"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07541"/>
    <dbReference type="eggNOG" id="ENOG502RK0U">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139292_0_0_1"/>
    <dbReference type="InParanoid" id="I1S0H8"/>
    <dbReference type="OrthoDB" id="4912193at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124675" evidence="1">
        <location>
            <begin position="17"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF75574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="162" mass="17359" checksum="D8CC5D720B4AF488" modified="2012-06-13" version="1">MKSFSLITLFCTLVTAAVIPRDTVFDGHCCFTLHDVANDAAVQENSNGNLLLNAGSTSGFFCIDLSNSQNILRDRSFNACFLNPSGEVKCVDPTPGFESWTLKKSGSNTLLHRDGATAFNSCSKTSTSSKGTVLFGDKHTGASTCKKTTLKVKNLKGTCKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1S1A1</accession>
    <name>I1S1A1_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG10501.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T08263</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319491.1">
        <property type="nucleotide sequence ID" value="XM_011321189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S1A1"/>
    <dbReference type="EnsemblFungi" id="CEF75935">
        <property type="protein sequence ID" value="CEF75935"/>
        <property type="gene ID" value="FGRRES_10501"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10501"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08263"/>
    <dbReference type="HOGENOM" id="CLU_1619172_0_0_1"/>
    <dbReference type="InParanoid" id="I1S1A1"/>
    <dbReference type="OrthoDB" id="10578909at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF75935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="164" mass="16723" checksum="9F89E560BE5C51A3" modified="2012-06-13" version="1">MVVEATPPETVPEDVLPTTDDAVTIEMETDDPVPVSADDDTVVTDPIEPAATADDDTVDAAPAGPSVAVAAPVELSISNAAPAEPMIVDATPTEKIEMNNTDITVTRDTAMEDPVPICTTDGNVPADDGVDAIDASVTRDVTMEDPEPVAITGAGGVVGTTVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1S1H8</accession>
    <accession>A0A098DDL2</accession>
    <name>I1S1H8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG10581.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T08457</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF76031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319580.1">
        <property type="nucleotide sequence ID" value="XM_011321278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S1H8"/>
    <dbReference type="EnsemblFungi" id="CEF76031">
        <property type="protein sequence ID" value="CEF76031"/>
        <property type="gene ID" value="FGRRES_10581"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10581"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08457"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019785_0_0_1"/>
    <dbReference type="InParanoid" id="I1S1H8"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="609"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="642"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="676"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="709"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="743"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF76031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="786" mass="88623" checksum="E09BED410C8C203E" modified="2012-06-13" version="1">MDATDENETTVLFDLIHQCLTSFDRVVKCNGAVLLTRSLEPHDSTKIGRTPVRTPFNFLGLRNRFSFWIDSIGAFSVKEPTLDQRLQGCGSVSANIANSLNTILKNLHRDPRVVRFLQTRHARQHKRPFYQDGTIIVSYSHEENLGEISPILRLDKTNSRGYDVSFPAARNKLCRQLGDDIAARRLILMQTKRQSRRRAVKRPLETMPLSNKDKADDPNPAQPAKRRDKDRSGSYPIVITGLTNDSLPDPRELSVGRLHTPPKKALPTLVSNMGTAKQDSFIYPPLPKVTPGATYVRCPFCLMALEIGGSEQDNMNNWKSHIDQDVEPYGCISPECSQSLLFFVHRRDWESHMESAHSKDWLRKVHALTWFCDFGHDPPVMFQTEVLWKEHMVDPKSHSSRWRMPTPFQLVALSSQRQRITPRDQFECPLCERVPDELSEMVANSEGDLTAMHNIVVSHVAGHIKSLSMMALPSLDVSAEGIRDNDNDSLLFARGSFQKLSNPDSIAQPPSGRDYMEDDTLPSLPWSFEDRDSIASVLHDHSMSWDDEFPDYTQPEAPPESAEEHWLEEWALWENEHDPALHEYPENDPILTHFRILQKPDFFVNAQDGTRTELSFAAQFGDIDAVNRLLTLGVDIDLADQDGQTPLLWAAYKGHEAIVQLLLKNAARVEKADRVYGRTPLSWAASKGHQDVVRLLLSNGANVNAVDNSQRTPLSWAASRGHLNTIRHLIEAGADKELADSGSGRTPLSWAVSNDQEAVVKLLLKQGVGFDTLDESHRAQLSWSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1S1Y0</accession>
    <name>I1S1Y0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG10758.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T20391</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF85889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325647.1">
        <property type="nucleotide sequence ID" value="XM_011327345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S1Y0"/>
    <dbReference type="EnsemblFungi" id="CEF85889">
        <property type="protein sequence ID" value="CEF85889"/>
        <property type="gene ID" value="FGRRES_10758"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10758"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20391"/>
    <dbReference type="eggNOG" id="ENOG502SH1Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122916_0_0_1"/>
    <dbReference type="InParanoid" id="I1S1Y0"/>
    <dbReference type="OrthoDB" id="6079484at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF85889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="113" mass="12462" checksum="AE684521D014F395" modified="2012-06-13" version="1">MSGAGGFYKYRCKYFYTHNCPNWVWVNNAPCASCLADGRDNEGSALPTWGLPRDIVVPQVLNGILQYTLMELVAPSEPGDDWTLRDKANRPPPSIPVTSAMPGIPGILAQHRF</sequence>
</entry>
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    <accession>I1S2L8</accession>
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        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325352.1">
        <property type="nucleotide sequence ID" value="XM_011327050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S2L8"/>
    <dbReference type="EnsemblFungi" id="CEF88245">
        <property type="protein sequence ID" value="CEF88245"/>
        <property type="gene ID" value="FGRRES_11016"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11016"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21023"/>
    <dbReference type="eggNOG" id="ENOG502RPJB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_461540_0_0_1"/>
    <dbReference type="InParanoid" id="I1S2L8"/>
    <dbReference type="OrthoDB" id="5097472at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF88245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="591" mass="68063" checksum="B3F82BA8802DC638" modified="2012-06-13" version="1">MACHGEDDNSKHNAENILITQTVHYGKISLPINLCFYSPFWNNPPREITIKFRTPTSAEISGESLQSLLNFRWGYIVNCGDVDIQEGNGRPKGRPVPEDTPLAPLRPPFKHNTHSMLFTTKINYGQFSISINTCFYDSFWNTNPHEITIQLQTPTKTVISEESFQSLCNRIWGYIIHCGDVDVRKSIGEKEGWKRNLDLIWKIMAIFVMISSIYWLFLETVGTVYVQPPFDTAVLPVLDEYAHILIQEITIGREYVPMQRLSLYITHQDMIVYEVCNEIRNKGGFWDEHHGLRLDPDEYLFYRREYGTPPGATDIVDLCQNTSESLHDAAISFSSTMYNIVYGLPYVSTGVFLDNAVYLARRFPKSDTCVGNGEGRSCDPLGTDWLVRFRRDILEYGIEAETRDIMKDMDDLVKCFKRVLENLDFLISIASHLQQTPSWFGLFRPKNPVVEQIQQIQQFQYNITQMSTKVSNFIDTQTNIIEQEASLAEWLSSLILWSQTHPSPYKIPSPSNANTIHTNPWAVWRPREENGNWCTVPRCPEPNADGDNVLVKLVPPSAEQAYGDMYEFMEFGKKVKHELAERVSNWEWGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1S2S3</accession>
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        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
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        <name evidence="4" type="primary">FG11076.1</name>
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    <organism evidence="3 5">
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        <name type="common">Wheat head blight fungus</name>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325281.1">
        <property type="nucleotide sequence ID" value="XM_011326979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S2S3"/>
    <dbReference type="EnsemblFungi" id="CEF87547">
        <property type="protein sequence ID" value="CEF87547"/>
        <property type="gene ID" value="FGRRES_11076"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11076"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21171"/>
    <dbReference type="eggNOG" id="ENOG502S4VJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042303_0_1_1"/>
    <dbReference type="InParanoid" id="I1S2S3"/>
    <dbReference type="OrthoDB" id="203796at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848:SF1">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF87547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="436" mass="49304" checksum="2F38903D89D21C1A" modified="2012-06-13" version="1">MGKPPSPSPPYRDDPDALSLHTTLGEPSYLDPVDEDIPDTGDPLLPSYDDAITEDTHTNTNTNTPPHFSDAVLLNFEGEFFTGVTKPEGHYAYTSKRIGKKRTTIGDEVVDLQDARSDADPDFLQEWVTMMAKHPPTPYIHITGTHQETRRDKDGKSKRDEVTDFRIMINMQNYLWPNFSPGNYTTTTLETAEPGQKTYRGTALKKRQEGSKGDIEVGQDKPSLKEWCHRYCAKATGTKVFRLTRTVSGMDTEVLRDSISASIRSTNYRGNITVEFPVANRAVDIYSTSFLNNWRLTRWICWIFYLTFLWIFSWPVLFFATKRYEVVQVDWAFSKSQPGGRKRYTTVSEAQWMDMYRPAIKQLCLDRYQGLAGDAFLNEVLAREPDPVNTNEDARAAMSVASAAFQGGRFNVTNGARSLMRLAGAATDQVGWGFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1S2W8</accession>
    <accession>A0A098E074</accession>
    <name>I1S2W8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG11124.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T21275</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325228.1">
        <property type="nucleotide sequence ID" value="XM_011326926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S2W8"/>
    <dbReference type="EnsemblFungi" id="CEF87009">
        <property type="protein sequence ID" value="CEF87009"/>
        <property type="gene ID" value="FGRRES_11124"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11124"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21275"/>
    <dbReference type="eggNOG" id="ENOG502SR18">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020807_0_0_1"/>
    <dbReference type="InParanoid" id="I1S2W8"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="PHI-base" id="PHI:1827"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14723">
        <property type="entry name" value="ZIP_Ppr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="236"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF87009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="553" mass="62065" checksum="AE27012736343BAA" modified="2012-06-13" version="1">MENTPSTARKRSSVRRANHVPRAHVQACPVYIKSLEDRVAELELALQGHGLDTESLAGSRISQDAAEATPEPRRSTDLNLLSLFIPEPSDVQDKGTSGYHALLGAITVPERTKFPPKSTTLQLAATYFEHSNFFSPILYQESFHEIITVLYHDLPNVDQGKPAQKFQLCMVLAIAIRLLNRIDSAVPTTASDSFFASAIGILTERPQATWKGNLQHLQNLLLIVQYTIFASNLSAAWHFVGLATRLAIDLDLLNETRLSSGNSEEVILDAETNKRRRVFWSTYILETNLCVVLNRPRSIPDEAVFTPLPSTSGPESCSPLANHCIEFRQLEYEIYHTLNYKPPANGAFFDYKVWKVGMKDRLVEWHATVPPVDTRSKLAPQNFFDGALYMTLVSLFSPSRHFPDLSEPELRDLARYASMSIELYREGFKEGKLRFYWRTTPNLFQSGAALVHCIKSLTLRGSVFDVDALKRSVSVCSTVLWGMAERYSPGTVYRDRFDELSASMSDVTTDLSFEISDDFPFGQFSIPPLDLNGTAGIWTSTPPTLDPWIFDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1S3A2</accession>
    <accession>A0A098DWM0</accession>
    <name>I1S3A2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG11277.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T21673</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325969.1">
        <property type="nucleotide sequence ID" value="XM_011327667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S3A2"/>
    <dbReference type="STRING" id="229533.I1S3A2"/>
    <dbReference type="EnsemblFungi" id="CEF86236">
        <property type="protein sequence ID" value="CEF86236"/>
        <property type="gene ID" value="FGRRES_11277"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11277"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21673"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028281_0_3_1"/>
    <dbReference type="InParanoid" id="I1S3A2"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF86236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="297" mass="33482" checksum="885B87277DE249BA" modified="2012-06-13" version="1">MEEARCLYQMRKIAGGHGLFAIEPIKAGTRIIHEKALLTISQAETRANAEYRCVIEQASRLSTDQKTKLFSLYHNPKKLTEFSFLKGQLCPGTDMDCSLVLAKFYTNAASITAGGLECGLFTEFCRMNHSCTPNICWVYDEPSAMMEVYAVRDISQDEEIYNSYIEVACSRQARIKELSNWGFHCSCFACEGPDAAQHDERRRRIGQIRGILDIYQDTKTDNDKPRFSEVPKTDLEALKLSQENASLLQQEGLTEQLGVSYGLCAKFAKGAALNNLANEYEEKEFDILVITTGEYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I1S4P9</accession>
    <name>I1S4P9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T01823</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316426.1">
        <property type="nucleotide sequence ID" value="XM_011318124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S4P9"/>
    <dbReference type="EnsemblFungi" id="CEF72712">
        <property type="protein sequence ID" value="CEF72712"/>
        <property type="gene ID" value="FGRRES_11817"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11817"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01823"/>
    <dbReference type="HOGENOM" id="CLU_179467_0_0_1"/>
    <dbReference type="InParanoid" id="I1S4P9"/>
    <dbReference type="OrthoDB" id="5078510at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF72712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="102" mass="11146" checksum="533032349BA2D6F1" modified="2012-06-13" version="1">MGCSHVRRESLLIPKKDGTSMLVAGVLKAEVRSPCDRLGSRRRGCPMPHEIGSGKEKGSLNDDRPIDDEIDHQETQKWIGGVALGLCVHPPEHIVEANQPSN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-03-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1S537</accession>
    <accession>A0A098D3S4</accession>
    <accession>A0A140TG13</accession>
    <accession>A0A1C3YIF7</accession>
    <name>VEA_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Developmental and secondary metabolism regulator ve1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Velvet complex subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ve1</name>
        <name evidence="10" type="synonym">veA</name>
        <name type="ORF">FGRAMPH1_01T03545</name>
        <name type="ORF">FGRRES_11955</name>
        <name type="ORF">FGSG_11955</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
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                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2011" name="PLoS ONE" volume="6" first="E28291" last="E28291">
            <title>Involvement of a velvet protein FgVeA in the regulation of asexual development, lipid and secondary metabolisms and virulence in Fusarium graminearum.</title>
            <authorList>
                <person name="Jiang J."/>
                <person name="Liu X."/>
                <person name="Yin Y."/>
                <person name="Ma Z."/>
            </authorList>
            <dbReference type="PubMed" id="22140571"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0028291"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2012" name="Mol. Plant Pathol." volume="13" first="363" last="374">
            <title>The velvet gene, FgVe1, affects fungal development and positively regulates trichothecene biosynthesis and pathogenicity in Fusarium graminearum.</title>
            <authorList>
                <person name="Merhej J."/>
                <person name="Urban M."/>
                <person name="Dufresne M."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Richard-Forget F."/>
                <person name="Barreau C."/>
            </authorList>
            <dbReference type="PubMed" id="22013911"/>
            <dbReference type="DOI" id="10.1111/j.1364-3703.2011.00755.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="653" last="662">
            <title>FgVELB is associated with vegetative differentiation, secondary metabolism and virulence in Fusarium graminearum.</title>
            <authorList>
                <person name="Jiang J."/>
                <person name="Yun Y."/>
                <person name="Liu Y."/>
                <person name="Ma Z."/>
            </authorList>
            <dbReference type="PubMed" id="22713714"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.06.005"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2013" name="PLoS ONE" volume="8" first="E68441" last="E68441">
            <title>Functional roles of FgLaeA in controlling secondary metabolism, sexual development, and virulence in Fusarium graminearum.</title>
            <authorList>
                <person name="Kim H.K."/>
                <person name="Lee S."/>
                <person name="Jo S.M."/>
                <person name="McCormick S.P."/>
                <person name="Butchko R.A."/>
                <person name="Proctor R.H."/>
                <person name="Yun S.H."/>
            </authorList>
            <dbReference type="PubMed" id="23874628"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0068441"/>
        </citation>
        <scope>INTERACTION WITH LAEA AND VELB</scope>
    </reference>
    <comment type="function">
        <text evidence="2 5 6">Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination (By similarity). The velvet complex hat acts as a global regulator for secondary metabolite gene expression (PubMed:22140571). Controls the expression of the aurofusarin and trichothecene gene clusters (PubMed:22013911). Also controls the expression of the deoxynivalenol (DON) gene cluster (PubMed:22140571). Regulates hyphal growth and pigment formation (PubMed:22140571). Acts as a positive regulator of virulence (PubMed:22013911, PubMed:22140571).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Component of the heterotrimeric velvet complex composed of laeA, ve1 and velB; Ve1 acting as a bridging protein between laeA and velB (By similarity). Interacts directly with laeA and velB (PubMed:23874628).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Enriched in the nucleus in the dark (By similarity).</text>
    </comment>
    <comment type="domain">
        <text evidence="2">The C-terminal PEST domain is a region rich in proline, glutamic acid, serine and threonine residues that is required for the light-dependent regulation of development and secondary metabolism.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5 6 7">Impairs aurofusarin and trichothecene biosynthesis (PubMed:22013911). Reduces deoxynivalenol (DON) biosynthesis (PubMed:22140571). Results in highly reduced sporulation (PubMed:22013911). Reduces the hydrophobicity of the cell surface (PubMed:22013911, PubMed:22140571). Shows increased resistance to osmotic stress and cell wall-damaging agents, but increased sensitivity to iprodione and fludioxonil fungicides (PubMed:22140571, PubMed:22713714).</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the velvet family. VeA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS231663">
        <property type="protein sequence ID" value="ESU06761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317246.1">
        <property type="nucleotide sequence ID" value="XM_011318944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S537"/>
    <dbReference type="SMR" id="I1S537"/>
    <dbReference type="STRING" id="229533.I1S537"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T03545">
        <property type="protein sequence ID" value="FGRAMPH1_01T03545-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G03545"/>
    </dbReference>
    <dbReference type="GeneID" id="23558774"/>
    <dbReference type="KEGG" id="fgr:FGSG_11955"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03545"/>
    <dbReference type="eggNOG" id="ENOG502S0HV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022491_2_0_1"/>
    <dbReference type="InParanoid" id="I1S537"/>
    <dbReference type="OrthoDB" id="5384689at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034250">
        <property type="term" value="P:positive regulation of amide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051176">
        <property type="term" value="P:positive regulation of sulfur metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043455">
        <property type="term" value="P:regulation of secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3960:FF:000001">
        <property type="entry name" value="Sexual development activator VeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF14">
        <property type="entry name" value="DEVELOPMENTAL AND SECONDARY METABOLISM REGULATOR VEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0749">Sporulation</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000435769" description="Developmental and secondary metabolism regulator ve1">
        <location>
            <begin position="1"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Velvet" evidence="3">
        <location>
            <begin position="26"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="217"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="PEST" evidence="2">
        <location>
            <begin position="435"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="458"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nuclear localization signal" evidence="12">
        <location>
            <begin position="40"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="C8VQG9"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="C8VTV4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="22013911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="22140571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="22713714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="23874628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="9">
        <source>
            <dbReference type="PubMed" id="22013911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="10">
        <source>
            <dbReference type="PubMed" id="22140571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="11"/>
    <evidence type="ECO:0000305" key="12">
        <source>
            <dbReference type="PubMed" id="22013911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ESU06761.1"/>
        </source>
    </evidence>
    <sequence length="532" mass="59052" checksum="D12D545C91770BD0" modified="2024-05-29" version="2">MATPSAIPTNSKRDTTAQFHRVTRGNRSLWYQLTVLQQPERARACGSGMKANSDRRPVDPPPVVELRIVEGPTLEEGKDVTFDYNANFFLYASLEHARPIASCRVSTPTTNNPPILTGVPASGMAYLDRPSEAGYFIFPDLSVRHEGLYRLTFSLFETTKEEQDFDIQPADGDLPPGVDFRMEIKTDPFSVFSAKKFPGLMESTQLSKTVADQGCRVRIRRDVRMRKRDTKSGGNNNNNNNAGNNAGNNGFERREEDFGRRRTVTPAAEDPHGIRNRSQSNSSEHRASYSDVSRRPSMVDSYPPPPPPPPSYDPTPSAPRHLAFGESSGPKYPAPRQYAHQPGLQITPVPANGPYPSAAQSPYAKTDAPYGYSRHLPPSCPSPAPSVNRDLYDRRQSTSTYVPPSPSVYSTEGHYRRDSQASYPPTPAAAPLPRMNTEPSRGSIKISALVEPMPVIEPQVDPLPELPPVNVGGKRKHESVFAQNTRPLFNGQRQMDPHYGRSHRGYSPDHDQGSYSRADGQISVIQFNKYEY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-01-07" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1S5P3</accession>
    <accession>A0A098DAF4</accession>
    <accession>A0A0E0RUJ1</accession>
    <name>WOR1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Global transcription regulator FGP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FGP1</name>
        <name type="ORF">FGRRES_12164</name>
        <name type="ORF">FGSG_12164</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002724" last="E1002724">
            <title>The Wor1-like protein Fgp1 regulates pathogenicity, toxin synthesis and reproduction in the phytopathogenic fungus Fusarium graminearum.</title>
            <authorList>
                <person name="Jonkers W."/>
                <person name="Dong Y."/>
                <person name="Broz K."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="22693448"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002724"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Global transcriptional regulator of pathogenicity. Regulates many genes during growth in putrescine medium and during infection. Involved in the developmental processes of conidium formation and sexual reproduction and modulates a morphological change that accompanies mycotoxin production.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Results in greatly reduced pathogenicity and loss of trichothecene toxin accumulation in infected wheat plants. Exhibits normal vegetative growth but shows defects in asexual and sexual spore development.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MIT1/WOR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS231663">
        <property type="protein sequence ID" value="ESU08050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318535.1">
        <property type="nucleotide sequence ID" value="XM_011320233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S5P3"/>
    <dbReference type="SMR" id="I1S5P3"/>
    <dbReference type="STRING" id="229533.I1S5P3"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T06223">
        <property type="protein sequence ID" value="FGRAMPH1_01T06223-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G06223"/>
    </dbReference>
    <dbReference type="GeneID" id="23558979"/>
    <dbReference type="KEGG" id="fgr:FGSG_12164"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06223"/>
    <dbReference type="eggNOG" id="KOG4476">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="5319641at2759"/>
    <dbReference type="PHI-base" id="PHI:2399"/>
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        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
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    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000431526" description="Global transcription regulator FGP1">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="J9N5P9"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="22693448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="22693448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="342" mass="37755" checksum="CF2ACBBE0A164020" modified="2012-06-13" version="1">MANSVLTATYEGYIRDTADALRIFEACLTGSLTHTARRPHDRERSTLITSGNVFVYEEGSSGIKRWTDGVNWSPSRILGNFLVYREMNQPFSPGEKKRASKKPKKQAGVAKAYDHRPQATRFSSMPNDPAGVCAGGDGGAGDEDRDLVGSLTDSYDFKPNSLIKKTISITHNGIPHHLVSYYTVDDVRSGRLVRPSDHEFFGRVQPRMELMSGQNFRVPLEDGGDEESRGVMSHGQQVMPYPCNDYQIFQHAYGNAAAPRTGQFTYGPPQNGTYAPVSVPATHAIQNGTYAPVSVPATPALQNGTYLPVPAPQNGSYYNLHQNVHQNVHQNPAYPWYHAQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1S6B5</accession>
    <accession>A0A098DJI6</accession>
    <name>I1S6B5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T13629</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321936.1">
        <property type="nucleotide sequence ID" value="XM_011323634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S6B5"/>
    <dbReference type="STRING" id="229533.I1S6B5"/>
    <dbReference type="EnsemblFungi" id="CEF78617">
        <property type="protein sequence ID" value="CEF78617"/>
        <property type="gene ID" value="FGRRES_12386"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12386"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13629"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_0_0_1"/>
    <dbReference type="InParanoid" id="I1S6B5"/>
    <dbReference type="OrthoDB" id="5407715at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05188">
        <property type="entry name" value="MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
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    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
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    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="2">
        <location>
            <begin position="36"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="1">
        <location>
            <begin position="199"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF78617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="379" mass="40965" checksum="BE839FC4E2F07CA1" modified="2012-06-13" version="1">MSNAAVPTTSTSLVLNSFNGRLDLENTPIPSPTPFGSVVVRVLSTPVRPHQRAGFHGKSSLSFKPPYNPGDGGVGRIISVGPDAVALKPGQLVYMNNFVTARDDPNTRVLLGIHDGGGPERDIKLFNLWQGFWRDVAIVPTENVLPLDEKILVHEMGYSYGDLNYIQRLSVAYGGIKAANLQAGDTVIVAPATGHFSGAVVELAAQIGCKVIAISRSASKLEPLTSRFPRVTALELTGDEKKDTEAIHVLAPHGVDAYIDVSPPAATAAPHHLTVSINSLSSFGRVIFLGMMFDIKINYASLMVRNITIKAKFMYTREELASLIKMIEAGVLKLGKEAGHRVVERGYRLDEWEEAVTVAETAVGWGEQVLLYPSPEVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I1S7F6</accession>
    <name>I1S7F6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T18465</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324236.1">
        <property type="nucleotide sequence ID" value="XM_011325934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S7F6"/>
    <dbReference type="EnsemblFungi" id="CEF88421">
        <property type="protein sequence ID" value="CEF88421"/>
        <property type="gene ID" value="FGRRES_12779"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12779"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18465"/>
    <dbReference type="HOGENOM" id="CLU_2320595_0_0_1"/>
    <dbReference type="InParanoid" id="I1S7F6"/>
    <dbReference type="OrthoDB" id="10274479at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF88421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="99" mass="11385" checksum="FAD3A16302381F7D" modified="2012-06-13" version="1">MSNQNIFDRFFVNPVGSFLVQHWRILLVIFLCLATVVVVASYTLCKKAEPQGRWRNDFQMVFYMSALSAFSKDHGGLWYQKKGATGSIRDETSRPAYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I1S7R7</accession>
    <accession>A0A098E3E5</accession>
    <name>I1S7R7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T19775</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324857.1">
        <property type="nucleotide sequence ID" value="XM_011326555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S7R7"/>
    <dbReference type="EnsemblFungi" id="CEF88127">
        <property type="protein sequence ID" value="CEF88127"/>
        <property type="gene ID" value="FGRRES_12892"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12892"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19775"/>
    <dbReference type="HOGENOM" id="CLU_1428117_0_0_1"/>
    <dbReference type="InParanoid" id="I1S7R7"/>
    <dbReference type="OrthoDB" id="10297182at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF88127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="190" mass="21269" checksum="9F9B07EA1BF0C69D" modified="2012-06-13" version="1">MSSIVPWGKAYYYPACHILISPRRMCLVDKVQCKWYRKMMAVVKPENSIRNIVVTFAYSKFFIRLMAKCPKANILGMPLDEEPLTNVPLNSSMKTAAKYVGTDAHKLTTLALVGGFKILRSLSSPNIVAGVYSFVLFPKGTKTQVQYSIQRHLVTTVSYSGISFLLSAEDAIVVYRETEHCEETKAGTQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I1S7T5</accession>
    <accession>A0A098E1G1</accession>
    <name>I1S7T5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T20117</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325017.1">
        <property type="nucleotide sequence ID" value="XM_011326715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S7T5"/>
    <dbReference type="EnsemblFungi" id="CEF87956">
        <property type="protein sequence ID" value="CEF87956"/>
        <property type="gene ID" value="FGRRES_12910"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12910"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20117"/>
    <dbReference type="HOGENOM" id="CLU_711836_0_0_1"/>
    <dbReference type="InParanoid" id="I1S7T5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF87956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="388" mass="42961" checksum="A50E17DB72E0447C" modified="2012-06-13" version="1">MARSRVPQLIGTVCLKLFWPKLEVSQLSSSYRASARSSHGALPSPGLPCQVPSGAISESILTPAKSHGMAPTIACSVAVLAEKLFSELQCSTPPISQLSQFFFLPGNLCLVSVQSPGKSAISALSYGNESRRVAGGDSRRSSNTMRVSWCELHANSGRLYLNRDILCWLRASISVSSSYKGSDITKCRFSKPYPTNDSWLAMTCRQSRRAAYDGCIRFNECYCVQYAAESAVRIMPTLFIDSRKLEPAIHTRAASRTLIETLLCRTEKTPNQSLHALHGPGPPPPPPSQEYGTCHIANDQAHDVILAFQIFPRQSTHEAETFQGPLVPIKVLEQFMEYGNGRDCAGHLEKKNRKHHKHGGHQKKSIRLVLSTWHPLDSVTRWLEVYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I1S7Y3</accession>
    <accession>A0A098DT27</accession>
    <name>I1S7Y3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T22833</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326278.1">
        <property type="nucleotide sequence ID" value="XM_011327976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S7Y3"/>
    <dbReference type="EnsemblFungi" id="CEF85016">
        <property type="protein sequence ID" value="CEF85016"/>
        <property type="gene ID" value="FGRRES_12958"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12958"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22833"/>
    <dbReference type="HOGENOM" id="CLU_2740231_0_0_1"/>
    <dbReference type="InParanoid" id="I1S7Y3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF85016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="71" mass="7625" checksum="03451D6C834CF3FC" modified="2012-06-13" version="1">MPCVRIRCNMYGSRGHGCTTISSMHRSRARSSAARLAQAQASYSTFMNDGSARISVVGAYGLRETRGGPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1S841</accession>
    <name>I1S841_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T23511</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326593.1">
        <property type="nucleotide sequence ID" value="XM_011328291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S841"/>
    <dbReference type="EnsemblFungi" id="CEF84635">
        <property type="protein sequence ID" value="CEF84635"/>
        <property type="gene ID" value="FGRRES_13017"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13017"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23511"/>
    <dbReference type="eggNOG" id="ENOG502S6FW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022947_0_0_1"/>
    <dbReference type="InParanoid" id="I1S841"/>
    <dbReference type="OrthoDB" id="5403181at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024500">
        <property type="entry name" value="DUF3074"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF14">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11274">
        <property type="entry name" value="DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="122"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
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        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
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        <location>
            <begin position="345"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF84635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="652" mass="71429" checksum="9534738774BE1527" modified="2012-06-13" version="1">MGGTHHEPLGSMGPVEWEQVPQDDLNEFIADIFSETQTVVESIPGPAPKESSTTGGRARSKTESAASAPEAKRALTLRQTAEAISHSQDLQKEWKEIKVNAKDNPLGINVYKLGAKDGRGAWFARRSVHEGLSFDDWKKGLSVEFSETMKVQGAPGSGNIRGIGADKRVEEKTIGDHGHLQVFQLSAQFPGPTAPRDFVTLLLTSETSVSPGQGSRPLRQYMIVSKPCEHPECPPRQGIIRGYYESVEVIREVPIDNFASRRSLSSADLLERDENKSSSQNPGTEPKPLNKPSTAVEWLMVTRSDPGGSVPRFLIEKGTPPGIVGDAGKFFKWVTSKAAHGFAEPEEPVAVPKTAGGTEAPVSEKRQPSTTPAPTTNIEANKVETVNLQNQDDPFPGSNGLYGVIAGAIGAASSYIPTSLLKTWGTGSDMASSDTNGSDIHAIAEEHHEVDSDTSSIRSFASALEKSVTAEGKANGSAVESHSETSHSNPQQSLADKELKKLEHKKKKLDEKLARIEERRQSKLVGDKEKDATMLAKLREKHEKEVAKQEEKYRREMRKLEEKRERDQRKAEERRRKAAEQEEKNKLSLELERVRAERDVAQRQIELLEGQVGELQAQNTMLVRKLGKNGLLDGIGSPASSVKSLQRANTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1S8P6</accession>
    <accession>A0A098DPK7</accession>
    <name>I1S8P6_GIBZE</name>
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        <submittedName>
            <fullName evidence="6">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG07806.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T25709</name>
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    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327626.1">
        <property type="nucleotide sequence ID" value="XM_011329324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S8P6"/>
    <dbReference type="STRING" id="229533.I1S8P6"/>
    <dbReference type="ESTHER" id="gibze-q4i4q2">
        <property type="family name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF83765">
        <property type="protein sequence ID" value="CEF83765"/>
        <property type="gene ID" value="FGRRES_13224"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13224"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25709"/>
    <dbReference type="eggNOG" id="KOG2565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019414_0_1_1"/>
    <dbReference type="InParanoid" id="I1S8P6"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
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            <begin position="9"/>
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        <location>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF83765.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF83765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="387" mass="44601" checksum="B6B7DE4FB17BBA28" modified="2012-06-13" version="1">MAQSNHDSIRPFKVSIPQSDLDGLQTRLRLTRWPDKEPVDDWSQGVPLAVIQDLCKYWQTEYDWRRCEALLNSYPQFTTTIDRVEIYFLHIQSKHQNATPLLLTHGWPGSVLEFRHVIEKLVDPESHGGSSKDAFHLIMPALPGYGFSGKPKETGWGHERTARAWAELMRRLGYMDSEWVAQGGDWGAFVVASLGYQAPKGLKGIHFNSIYFENKNEVQVPIKDTKAEEKAMRLDNFRDTGFKGYSLEQSTKPQTIGYGLADSPVGQAAWIYEKYRDWTHHDGDVEALFSKDEMLDTIMLYWLTNSGTSSARYYWECASATTAWEIHIPVGVSWFGGDNSFAPKEWCERYYKNIVHWNELPRGGHFAAWEQPDAFVAEIREWHKQVR</sequence>
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    <accession>I1S9Y8</accession>
    <name>I1S9Y8_GIBZE</name>
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            <fullName evidence="1">Chromosome 1, complete genome</fullName>
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        <name evidence="1" type="ORF">FGRAMPH1_01T06841</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318828.1">
        <property type="nucleotide sequence ID" value="XM_011320526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S9Y8"/>
    <dbReference type="EnsemblFungi" id="CEF75225">
        <property type="protein sequence ID" value="CEF75225"/>
        <property type="gene ID" value="FGRRES_13669"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13669"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06841"/>
    <dbReference type="HOGENOM" id="CLU_1927798_0_0_1"/>
    <dbReference type="InParanoid" id="I1S9Y8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF75225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="131" mass="14505" checksum="19AA980995D17CCD" modified="2012-06-13" version="1">MIFHLPRHARIILDGSCGSHLGTYEAAFILSLTFGDLVWSEFNDGTSLGETQWEPLPSSHCSFSGRIHRLSSAPVSEQVPIGSDKTLTMCSATLLSVMVHACPGLPRLPRPKDWYWDAKDTPPFPDCTCTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I1SAL4</accession>
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        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
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    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325491.1">
        <property type="nucleotide sequence ID" value="XM_011327189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1SAL4"/>
    <dbReference type="EnsemblFungi" id="CEF88258">
        <property type="protein sequence ID" value="CEF88258"/>
        <property type="gene ID" value="FGRRES_13895"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13895"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20735"/>
    <dbReference type="HOGENOM" id="CLU_1678054_0_0_1"/>
    <dbReference type="InParanoid" id="I1SAL4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF88258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="157" mass="17470" checksum="C7B7559E90791202" modified="2012-06-13" version="1">MKREPLSYKRANTSDSTDHPYLVKFMHNPSVLREPRLWNTTIAQILNASLICGALALGPVSAHISLRLTVRNRVSLGFPMGSFFPTLMTTDEDLTWLLLLWLLSSRCPSTVTTLLSTLAPVSVPRCFFMTYVTYEEILANAFLQDDTGLPAESSSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I1SAQ9</accession>
    <accession>A0A098E3J7</accession>
    <name>I1SAQ9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T22191</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325725.1">
        <property type="nucleotide sequence ID" value="XM_011327423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1SAQ9"/>
    <dbReference type="EnsemblFungi" id="CEF88177">
        <property type="protein sequence ID" value="CEF88177"/>
        <property type="gene ID" value="FGRRES_13940"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13940"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22191"/>
    <dbReference type="eggNOG" id="ENOG502T5TQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152679_0_0_1"/>
    <dbReference type="InParanoid" id="I1SAQ9"/>
    <dbReference type="OrthoDB" id="4860686at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF88177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="132" mass="14972" checksum="A1F91A53281B417C" modified="2012-06-13" version="1">MCFDITSISLAMATSVVANRLYVHMSCLVKRCDSSKGKFIADFASDDVNASTVRRGTDVPCMTEFYMDWLDRRAHPKFSESNNYCLGIGLGVEINCNGGWNCYMAIWKEVRCNWYEVPVSETDLRVVTCCYC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q4HX89</accession>
    <accession>A0A0E0RX59</accession>
    <accession>I1S125</accession>
    <accession>V6RRL4</accession>
    <name>BTN1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName>Protein BTN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">BTN1</name>
        <name type="ORF">FGRRES_10419</name>
        <name type="ORF">FGSG_10419</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in vacuolar transport and vacuole pH homeostasis. Also required for cytokinesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the battenin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS231669">
        <property type="protein sequence ID" value="ESU17131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319393.1">
        <property type="nucleotide sequence ID" value="XM_011321091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4HX89"/>
    <dbReference type="FunCoup" id="Q4HX89">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="229533.Q4HX89"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T08061">
        <property type="protein sequence ID" value="FGRAMPH1_01T08061-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G08061"/>
    </dbReference>
    <dbReference type="GeneID" id="23557327"/>
    <dbReference type="KEGG" id="fgr:FGSG_10419"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08061"/>
    <dbReference type="eggNOG" id="KOG3880">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029663_1_2_1"/>
    <dbReference type="InParanoid" id="Q4HX89"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903826">
        <property type="term" value="P:L-arginine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015819">
        <property type="term" value="P:lysine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018460">
        <property type="entry name" value="Battenin_disease_Cln3_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015974">
        <property type="entry name" value="CLN3_BTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0029">Amino-acid transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
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        <location>
            <begin position="1"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="455" mass="49409" checksum="80E427079B5E1E8B" modified="2012-10-31" version="2">MSGISPSSSGLLPMPGAPSSSWSAYKARVAALLGHHDTKVVVAFWLFGLINNVLYVIILSAAQDLVGSLPKGVVLLADVVPSFLTKLIAPYFIHRIPYRTRILIFIALSAAGMLMVALTPATQSVAIKLVGVILASISAGGGELSFLGLTHFYGPMSLAGWGSGTGAAGLVGAGLYVMFTDWWGLSVRSSLLISACFPAIMFLSFFVILPLGPLREGTRKDYDAIPDLEDEDVNHMDQGTASSALLAPGPSVASTAYSARNNQESLTVRDRMNKVKKLFVPYMMPLLLVYVAEYTINQGVAPTLLFPLEESPFDEFRAFYPFYGFLYQLGVFISRSSTPWIRIHHLYLPSMLQIANLVLLTLHAMYFFLPSVYVVFIIVFWEGLLGGGVYVNCFAEIMENVPAEDREFSLGATTVSDSGGISIAGLLSIVMETKLCNYQVAHGRDWCQRISAQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>V6QZF0</accession>
    <name>V6QZF0_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="3" type="primary">FG02231.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T05377</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318126.1">
        <property type="nucleotide sequence ID" value="XM_011319824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6QZF0"/>
    <dbReference type="FunCoup" id="V6QZF0">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="229533.V6QZF0"/>
    <dbReference type="ESTHER" id="gibze-q4ikm7">
        <property type="family name" value="Dienelactone_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF74493">
        <property type="protein sequence ID" value="CEF74493"/>
        <property type="gene ID" value="FGRRES_02231"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02231"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05377"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_2_1_1"/>
    <dbReference type="InParanoid" id="V6QZF0"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF74493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="250" mass="27265" checksum="83C0D249D75BC892" modified="2014-02-19" version="1">MASNQPAKCCTEGVRHEGEPTGKMIKLPSGIAAYLATAPEGKAHQGAGIVYVADIFGIWNNSKLMADQFAANGYTTIIPDLFNGDVMPYPPVDIDIMSWITKGANGDNPHTPAQVDPIVVEAIKYLQDQGLSKIGSVGYCFGAKYVIRNYKAGIKVGYVAHPSFVEEEELKAIEGPLSIAAAQTDSIFPANLRHRSEEILIETGKPFQINLYSHVEHGFAVRSDLSNKAKVFAKEQAFVQAVQWFDEHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2024-01-24" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D7I7</accession>
    <accession>A0A0E0RUK4</accession>
    <name>A0A098D7I7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T06249</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
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                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CEF74929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="229533.A0A098D7I7"/>
    <dbReference type="EnsemblFungi" id="CEF74929">
        <property type="protein sequence ID" value="CEF74929"/>
        <property type="gene ID" value="FGRRES_20079"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06249"/>
    <dbReference type="InParanoid" id="A0A098D7I7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF74929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="77" mass="8250" checksum="DB96ADE50E9EABB6" modified="2015-01-07" version="1">MYRTFNSRIALRALSRGIAPATCIGAFVATRPVIRCDAPTLATGPPRRNRSFDVSPDTVRQLSSGSIAGDLKRMVGS</sequence>
</entry>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DBV8"/>
    <dbReference type="EnsemblFungi" id="CEF76434">
        <property type="protein sequence ID" value="CEF76434"/>
        <property type="gene ID" value="FGRRES_08163_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09263"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DBV8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098717">
        <property type="term" value="P:pantothenate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF4">
        <property type="entry name" value="PANTOTHENATE TRANSPORTER FEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="85"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="110"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="140"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="422"/>
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    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="26"/>
            <end position="446"/>
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    <evidence type="ECO:0000256" key="1">
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        <source>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF76434"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="481" mass="53567" checksum="CF34A08E7F4E47BF" modified="2015-01-07" version="1">MAVVDYLWGDTSKEEKKLIRKLDFFILTFCCFSFFFNHLDRQAFANAYVAGLKEALDLHGNQYNVLLSMTSAGMLVGQIPSSIIIHKIRPRIWLSSMVVTWAGLTMASAACKTYSQLCAVRFLMGLAEASTYAGSIYIMGSWYKSDEIGKRTAMFTVGGQVGKMFAGAMMAAIHESMEGHGGLAGWQWVFLIDGIIILPIAVFGFFYFPDVPEYTDAPYLNEKERQLALDRLPPKREDGHSIQAWSLIKRVLGNPLVYIFCVFSILGTALQSYVVQGLMLLYLKFRKDIDGFTQTEVNTLPIPTHAVGIVAEFSISFFMDRYNQRMSLGFILCIIQIACSIVLLIPNMSVPGNLTALYLSASSYGIAPLMYGWASNILARTADDAARSVTLASMTAVDGLWWTFWGIVLFPADDAPYWKNGYIAMLCVSTAMAGWLFVVRWVDRYTAEKYPAGEHTSASSLVPTQVNYSTMSQPEKDNKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
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    <accession>A0A0E0S0F5</accession>
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        <submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DEX1"/>
    <dbReference type="EnsemblFungi" id="CEF76980">
        <property type="protein sequence ID" value="CEF76980"/>
        <property type="gene ID" value="FGRRES_20136"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10355"/>
    <dbReference type="InParanoid" id="A0A098DEX1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF76980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="194" mass="21208" checksum="BF114E310A7C53D4" modified="2015-01-07" version="1">MREQCYNCISPGIAMLPSTRPGQRLHCSEVFVNGSSVNSKASSLRIVSTVSLLLLSGDQLIGLAVVRLPASTVLGLVVQDEVLHDGHPSSGCRATQRGRKYHYPYQDRVKQPCDKVQGGLQDYTHTESPNSKEFNVRTGLTVLAVALVIPRTAPMVIKYEGKPGTRPLPGPKWVLGSIQLGSWTDDHDDTFVRD</sequence>
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            <fullName evidence="3">Chromosome 2, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DFE4"/>
    <dbReference type="EnsemblFungi" id="CEF76676">
        <property type="protein sequence ID" value="CEF76676"/>
        <property type="gene ID" value="FGRRES_17053"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09747"/>
    <dbReference type="eggNOG" id="ENOG502RAAD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DFE4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="204"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
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    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF76676.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <sequence length="335" mass="37285" checksum="87891B2C0429FECE" modified="2015-01-07" version="1">MELPPRDVSRTLGKKRSARASALTLSLSPERAQHQNHPQRSITSPAKPSSAMRSTHSSLFSPDLLPRSASAVPHHHQHHRNISVSRPSPSSIDYGSMHSEARAESALTVRPPTTLERGGSPPLTPFPPWVSEEEDEGDEECENRTWGENSTTKRHSYDGGHVPVTILRVEGKWVVSSVIHGLVLALQFAVTLGVFSALMWITVWKENDPGNDFDNWLWKFADPSLVVVLLLCATSLIIHEIKVLSSVALLYLESLILIATTVASFVLWTRCFQEESRSVKGVLMGSNVLMWGLAFFGFVRAVVIWKVEASEGDVDQERAVMYGTFVPWDERRESL</sequence>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DIL1"/>
    <dbReference type="EnsemblFungi" id="CEF78779">
        <property type="protein sequence ID" value="CEF78779"/>
        <property type="gene ID" value="FGRRES_15213"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13953"/>
    <dbReference type="InParanoid" id="A0A098DIL1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF78779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="61" mass="7198" checksum="6C4E6AFA19EA91D1" modified="2015-01-07" version="1">MTLDPVSQNDPTGKRLNGWYNVKQNMPSAPYIKSHGKIKYKLEREVRNIISVTARWIRRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2024-10-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DIV1</accession>
    <accession>A0A0E0S4C7</accession>
    <name>A0A098DIV1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG03530.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T13097</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DIV1"/>
    <dbReference type="STRING" id="229533.A0A098DIV1"/>
    <dbReference type="EnsemblFungi" id="CEF78352">
        <property type="protein sequence ID" value="CEF78352"/>
        <property type="gene ID" value="FGRRES_03530_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13097"/>
    <dbReference type="eggNOG" id="ENOG502S5SG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DIV1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01821">
        <property type="entry name" value="Rhamnogalacturan_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="168"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF78352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="381" mass="41505" checksum="AD5CBB2B38C63153" modified="2015-01-07" version="1">MDPKRLRDLPWLSIVHAMLSDYWLEVPDPPISILANFLDYPHETRTLTYPTALNIFINQAFKLTVPTGVETRAIQDRTRKPRYSPAASLPTVSSLIVIDSPHAEAAHGQMTWIMKMNAAPANLNIGAPKTRTFDSPRLIMKFSAIACAALSIFGGVQAAKSPFFILTGDSTVATGGGWGDALLNGTKKPGGGINLAKNGATTVSFRDLGLWDAALDNVKTQKAKHEAIVTIQFGHNDQKTLTLEQYSDNLSTMIGEVKAAGGTAIIITSLTRRTFKDGKVVENLSKERDAAIGVANKAGVKYLDLNTASTKYVNAIGQENADKYNEIEGDRTHLNMSGKIVFGRMVADMLVQKRPDLARYIKSNKKLSQLIRDGVFTTGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DM68</accession>
    <accession>A0A0E0S6A6</accession>
    <name>A0A098DM68_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T14455</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
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                <person name="Park J."/>
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                <person name="Regev A."/>
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                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
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                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        <citation type="submission" date="2017-01" db="UniProtKB">
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                <consortium name="EnsemblFungi"/>
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            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </evidence>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
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                <person name="Ma L.-J."/>
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                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
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                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
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                <person name="Muehlbauer G."/>
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                <person name="Nelson D."/>
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                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
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            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
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                <person name="Turgeon B.G."/>
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                <person name="Yoder O."/>
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                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
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            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A098DMZ8"/>
    <dbReference type="STRING" id="229533.A0A098DMZ8"/>
    <dbReference type="EnsemblFungi" id="CEF83241">
        <property type="protein sequence ID" value="CEF83241"/>
        <property type="gene ID" value="FGRRES_12973_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23015"/>
    <dbReference type="eggNOG" id="ENOG502S997">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A098DMZ8"/>
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        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
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                <person name="Trail F."/>
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                <person name="Chang Y.-L."/>
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                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
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    </reference>
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        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblFungi" id="CEF84030">
        <property type="protein sequence ID" value="CEF84030"/>
        <property type="gene ID" value="FGRRES_20352"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23879"/>
    <dbReference type="InParanoid" id="A0A098DQ95"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="CEF84030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="64" mass="7309" checksum="C7378FB70544118E" modified="2015-01-07" version="1">MGSNPLFDETLVQAEWLLAMAMDNWMGTPCATFLFGLQDPCSPYAVLRTSIPRVEIPWTQRDYL</sequence>
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            <fullName evidence="2">Chromosome 4, complete genome</fullName>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DQA9"/>
    <dbReference type="EnsemblFungi" id="CEF83549">
        <property type="protein sequence ID" value="CEF83549"/>
        <property type="gene ID" value="FGRRES_15441"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25623"/>
    <dbReference type="InParanoid" id="A0A098DQA9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF83549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="75" mass="8590" checksum="680D4D68D2741C8F" modified="2015-01-07" version="1">MLNNEESSTDATRLIARQPVMPAPNEIIGAERQEKPLCHGCERSEMVQLVKERPRNPKNTKTNNLKAWSKQHKPI</sequence>
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            <fullName evidence="2">Chromosome 4, complete genome</fullName>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
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                <person name="Borkovich K.A."/>
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                <person name="Freitag M."/>
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                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
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                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
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                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
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                <person name="Coulson R."/>
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                <person name="Danchin E.G."/>
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                <person name="Goff S."/>
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                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
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                <person name="Yoder O."/>
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                <person name="Zeng Q."/>
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        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
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                <person name="Urban M."/>
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                <consortium name="EnsemblFungi"/>
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            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
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                <person name="Borkovich K.A."/>
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    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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                <consortium name="EnsemblFungi"/>
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        <property type="gene ID" value="FGRRES_16659"/>
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        </location>
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            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF85114.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF85114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="632" mass="71113" checksum="D397901FEC3DF118" modified="2015-01-07" version="1">MSLRRSSRLTKVGDNQQEVADLAHQVISSEPKRGSKRKIELPDPNLSTKGAPKTAKTKHAASKTKKPCIQSSNALKIDRLSNLPPEILSMVLNNIKEKSTLSRLSRTCKKYDLLITPLLYKRISVAAMFHAHIGKLIRTLEPHLSIQQRKQLKKEGTYKGQKDIYPSNLRPDEKPICVNHVRQLVIGSVQAGRNHDYIVHRYIEETLKNTDNIEILESCFVTESMAKRIAKLEKLQALSLDLGYRDYQALYGIKNLKHLALQAYIQTDLLHSLLLNSRSTLRSLNLNTNSLDFFNHLNQIVSAAEQDTENQHYFTALKSLTIQVSDLDSTSIRSLMRATNFAGLQELHIELLPEISSVFFQQLTDLFSTTSTSDLEVRLRNLKIDMRTSGYNVTESQQKAVTETKSSFLNSFNTLKSLELFDYGQYPLEISENPGLPNSLVQAILQHKGLERLSISYNGIIGGYQLPYLTPSTIGSLIDNLPLLREIDIAPEEHDLDQLGSVLSRASNIERIVFSCTSSWASHIRTDDPTKPLLHSVLKGFLCRSHPGDVGQLKWEEICKLRLVTVNCQIYEIASKFGKGGKGIGKPEKFTVPGNPKREVMFRNITGTGPATLHVGFDPTFQWVEKVSKDLD</sequence>
</entry>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098E0M6"/>
    <dbReference type="EnsemblFungi" id="CEF87157">
        <property type="protein sequence ID" value="CEF87157"/>
        <property type="gene ID" value="FGRRES_05441_M"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RNM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098E0M6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010018765" evidence="1">
        <location>
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            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="92"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF87157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="317" mass="35427" checksum="173658B43C29D3F0" modified="2015-01-07" version="1">MICFYVLLCLIPEQTTLTLLLLRTQRHNLSTVTRELITINIYCSTGIGIAKLTKRFATTSIPISNSQIYNNSTSVMPAPSMSNPQSLDSAAFRNFCKLPTELRLKIWNYNLPPARLVPIQFGSSWPGCSESPSWTGCTSSATIPSNLHACSESRNEALKYYGLGFGFARGPGQIFLDPERDILYFGPRDGYMAADSQFQTIMSMCDPEELVLVRRLAINDALFWVDDSYRSMTAASLTVELLRRIQARMPGVEEIIFVPRPEEARGPESYIEPSMVYMRMAHQIQTALATLCEQTPGWTPPCWRILPLSAFQSVGAA</sequence>
</entry>
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    <accession>A0A098E2F3</accession>
    <accession>A0A0E0SPB3</accession>
    <name>A0A098E2F3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 3, complete genome</fullName>
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    <gene>
        <name evidence="10" type="primary">FG11416.1</name>
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    <organism evidence="9 11">
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <accession>A0A098E4V7</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
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    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="FGRRES_15624_M"/>
    </dbReference>
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        <property type="component" value="Chromosome 3"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF88742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="45" mass="5509" checksum="E90B519EC296C09C" modified="2015-01-07" version="1">MPEDGHQTRKPVQDRGARLYPPYRTIRVPMMWTKWVKLYTTLYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098E4W9</accession>
    <accession>A0A0E0SQN1</accession>
    <name>A0A098E4W9_GIBZE</name>
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        <submittedName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098E4W9"/>
    <dbReference type="EnsemblFungi" id="CEF88744">
        <property type="protein sequence ID" value="CEF88744"/>
        <property type="gene ID" value="FGRRES_04897_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16589"/>
    <dbReference type="eggNOG" id="ENOG502SPX2">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A098E4W9"/>
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        <property type="component" value="Chromosome 3"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF88744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="319" mass="35076" checksum="986B8EE2CBA8F432" modified="2015-01-07" version="1">MQDACRYGTSTPQRPPTREWWFSSPPSALSVKEKGNPPGRLSLPIPRSSVELGRLVLDPKYPNQDFCQPTIKKDPTQGDQKATGFEIETQQFKDFRSTVTRAKGTRLEASLLNILSLAPSSPKSTSTTVTGPLCVLHQLGDTNAFFKAACQQTHVRIWLEEQSWRLRSTVYLVCGFEALADANVSLAREDKTSLDMSVNVPSALLTAPTGVPVPGLDVGAGVSVSRESSENVEYTAVGEQVFSIQYRKISFSWFSPHKVDKAHLEKGNRWVSCMSTRSGQGDDECIECEVAEPIAPSDLVGKYESVEIDGETILYKAEI</sequence>
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    <accession>A0A0E0RRJ5</accession>
    <name>A0A0E0RRJ5_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Sordariomycetes</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RRJ5"/>
    <dbReference type="EnsemblFungi" id="CEF73870">
        <property type="protein sequence ID" value="CEF73870"/>
        <property type="gene ID" value="FGRRES_15874"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04125"/>
    <dbReference type="eggNOG" id="ENOG502S5CN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0RRJ5"/>
    <dbReference type="Proteomes" id="UP000070720">
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    <dbReference type="PANTHER" id="PTHR38049:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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    </evidence>
    <sequence length="200" mass="22577" checksum="0F7AC7F87A9C8F0F" modified="2016-04-13" version="1">MVIGLLAIAAIPTVTGVGNAVSAQKRQNESMSKEQEKFHLTFMLRQNGKIEEVGQGVLVDKKMYLNLSDAPVQGYRFLGWFFKYPSDEGHLGLVSMVSDDPPALNWIFVDKDTHAVTFGGKKDTIDHVIGPWGWTADEKFLTLKGDHDSFVAVRGDDGKWSVYWDPEGDIEDEIDDEERCQPVRLRRRPQLGMESSYVKK</sequence>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <property type="entry name" value="P-loop_NTPase"/>
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            <dbReference type="EnsemblFungi" id="CEF85797"/>
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    </evidence>
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    </evidence>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0E0SJC1"/>
    <dbReference type="STRING" id="229533.A0A0E0SJC1"/>
    <dbReference type="EnsemblFungi" id="CEF86534">
        <property type="protein sequence ID" value="CEF86534"/>
        <property type="gene ID" value="FGRRES_16515"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18431"/>
    <dbReference type="eggNOG" id="KOG4157">
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        <property type="component" value="Chromosome 3"/>
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    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF4">
        <property type="entry name" value="SH3 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G13610)"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF86534"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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    </evidence>
    <sequence length="334" mass="35607" checksum="3919280AA82E4013" modified="2016-04-13" version="1">MFPLCRNAQSAGLVFLLASTWAPLAHALDIEYCSDFNTGETSSNYSIYQTNGLCHDHCFDDYAYAITQGKLCWCSNYAPVKSVQDSKSKCNTPCPAWPKEVCGGDGVYGYVNLGNIEPSGSRGPSPSSTKTDQNESSTEASETKATSTDDEEPTASATDQQSSIVQTVTAGGTVRTVTVAPSQTGGTIANENTSGTTDKSGLGTGQVVGIVVGVIAAVILAAGVVLFLWFRRKKQQNEQEAYRDDPSIRDSSSGIAQRPDMSTTNGSPIASAAAGSRNSTLQVDPRMDPFKQGLYVRSASHESINTLRDDHDYSRRIQAPKVLRATNPDPTPEP</sequence>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May be involved in protein sorting and cell wall formation.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YHC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00517"/>
    <dbReference type="eggNOG" id="KOG1786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YHC8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23295">
        <property type="entry name" value="Arm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
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    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="8">
        <location>
            <begin position="1818"/>
            <end position="1949"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="7">
        <location>
            <begin position="1988"/>
            <end position="2280"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="2412"/>
            <end position="2453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1252"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1291"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1739"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1252"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1265"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1739"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1786"/>
            <end position="1806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00054699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SCB64004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="2597" mass="292662" checksum="AE2CF519773CEA33" modified="2016-11-02" version="1">MASIPRRYRSSTSASNPPQTKSFEILKGLLEALSIDTTLHQQDGFPQTPPLLRKLRHIIQHISATRSPVHQDDFRHADGFETILNLLRAFSGYYDPDKRTDADMLSLFKLIGDCLNLFSVALRGHAGNRRYFQYKVEGGGWEALEQVIASIGLGGAEPDAWISCHIFGKLLAFSLDDEALDLLCQSIGQSLRPDDENSPKEDESDSAEEQWDLVLAKSAENITPGVREVVNAKTIIRHPEILRAVVSFWTAIPRMKDGLANPASLLVLETIHCAISVSIYNRAAVHSTGALSQFLRVAFNADSALSPPEREKVLAICKILMYLGVNEPADTQFLLSTPGSEASEFCLQMTNKHTGPPFFQFDLSLHGHSSLELSSLGRSFPPQSSAGYTFTAWIRVDSFDPTAHTTIFGVFDSTQSCFVLMYLERDTHNFILQTSVTSNKPSVRFKSVSFKEKKWYHIAIVHRRPKTMVTSKASLYVDGEFSEQIRCNYPHLPPLATGAHDSFASFNSNQNKTNPVQAFVGTPKDLSNQIGPGLVFSRWSLASAHLFEDALSDDYLAVHFGLGPRYQGNFQDSLGGFQTYEASATLGLRNEIAHPGKGETSDIIRAVREKAGSLLPESKILLSILPTATFPENVQFYDTGLLRSLPRNCARNLFRASNQEGAPLAINCAVPSLPDSLFRVQGLLSFRGNPIVVVPSYLDENLWRLAGFTPLALKLFERASSIEETVRSAEMLFYCIRQSWRNSEAIEKDNGYGILAMLLRVKLGYDRGSSDSAVTRLQVSNDDRDRLAFQLLSLILGFVGYNHVEPMESFIINPLAYRILLIDLDIWRKSAPRIQELYYKQFVTFAVKSKYHEFNSRRLIRMRIVKRLLDAMKGEVVSEDTVSHFMGAFEILVTSNFSQEVMRSLSLFITYAFHSQPLPVNRSPRALSINSRTGTPLPRRRGTPTDPTAAGIASGLKFLTKKQLGVKVLSMYSRILCEKGNTTHIKKFARTVTNKWLLYLLAEDDPEVVVHGCKILARLLVTHGSNYTSKFAGKSGGFVIMSNRLKRFWDMPTLWPICFSILFGYDVAEINFDRNFDFFNILETFGKRKVVYPESLSVITAMLQHGLKDVMRHQDDPDSPATYVDPASHTLKKFASAKDLRPEMRPRASSMNLTTALATRSNFSRDSERVASYAGVLHTVIRFLLDLHERSTEFRDFALTSEWVRLLLSALYPVIVSADAVTPETELNSGDTALTFEGTDVIIRPISGSGSHATPIVRTTSVDPVPSPQSTPPKGTPLRRASSFVLLTQQKSPVGPSTARLSPALPSPRSTPSKRPSSDILDGLMELVVSVFMDQLLSRKDFSGFGLFTKVPPGFREHQAYFESYILKHVVAQLEKNIQLNQKAICEPRVLTNLSRLCQHMSEAIFEGWFLNGAEVMIDFIGMLLEFLQRPDIASLKSVRLCSQAVNSIRFCLLRIILLRLSDLDSSDTTLVEAKQFMGKMAYWQMSILGSFTGEDQFLKLFWYQLYTKLISDKMPLRTAAANFLRVILVQKPEESNELIHSCMSPDQKQLSKDFQQLTGVDDESFVEWVDKHRPSLDVLFFGGMSKTWEDFVSSENARTAETSKVRLAKRKDKLRVWHAENINTEKTLLSHDIGNSAWMKSIYNSEYFKYQRIMQDQQDDLVFLSDAYKKMERDLMRPGAVFSEAAPPKWKLDRTEGRNRMRLRVLPDFTISKDEYQPKRKASEVLQTLRLNTSASPAPSIVTSAVSPTKTATPALPESNNETPQFTEEPESTVPAEQPTSGVAPEDDFELVDDPNDPNEGDEGFEDKNRKVMRRLERGDQVQSAYNISRIIGLEACEGILIIGKDALYIMDNVFQCANGDIVNVWQAPPEERDPFSQIVTDAKTSEKRQNNKEQESRHWRWHDVISISKRRFLFRDVAIEVFFTDGRSYLLTTINPVVRDNLFIKMLSKAPHTTGANTLPNPEDAWRLESLKVFDESPQGFGSKFGTFFNASPWNPILKKWQKGEISNFHYLMMVNTMAGRTFNDLTQYPVFPWVLADYTSEDLDLDDPNTFRDLSKPMGAQTPHRVGGFVESYNALEEIGEVPFHYGTHYSSAMIVSSYLIRLPPFVQSYILLQGGSFDHADRLFQSIPEAWQSASCKNKTDVRELIPEFYCLPEFLTNVNGYNFGNRESNGVKVDHVELPPWAKGDPRIFIAKHREALESPYISENLHQWIDLVFGFKQRGEAAVENLNVFHHLSYRGATDLDSITDAKERAILAGVIHNFGQTPHQVFMKSHPAREHVRSPARRLDTSVFSLSCLPHPLLESHERVASLLYASKLDRLLCASPFRLNFPSYDKFLEWGYADNSIRFFFSDNRKPAGLFENLHTGQISCACFADSKTLITAGEDCVVSVYALQTAHGKPVELLPRSSLFGHKFPVTTIAVSKAFSTLLTVSTDGQAFLWDLNRLSFIRKLPLVRPVESARINDISGEILLCSGPNVILYTLNGTLLLEQNVCFDQDDYIHSCAFYEGAGNEWLDNYLIFTGHKRGIVNVWRRSIVGSRWTLELLRKLDHVDYKNEKGANTEAGMTCISPMPTCVYTGDDDGRVYEWNLLSRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YHY7</accession>
    <name>A0A1C3YHY7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FGRAMPH1_01T00001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB63976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00001"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YHY7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1234"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1267"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="257"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="326"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="617"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="794"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1331"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="813"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="829"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="872"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SCB63976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1378" mass="153499" checksum="60657AAFB180F30C" modified="2016-11-02" version="1">MTNNPPDRPVGPTNTDLKSRDSFAVRQTSVFLPDHVQNMGANDDSNDDEIEKLRDILNCMDKSQIDARDADGDTALHNATRRGFKRVALKLFSVGADVSVVNDSGNQPLHIACFKGLFWFAKELVNRGADIEAGDKHSQSPLFIASWEGHADIVELLLQHNAETKVLNVNGVTPMSMAFNWVTNNNGWSPLHEAISDDRMDVVDLLLEAGARVDHRDDDGWTPLMSAVCRDNVAATRKLLEHDKTLGVRQLETRDALGYTPLAVAARRGFVAGVRLLIDAGADCNALDEGSQRSVLTDACRFRQAEIVKVLLDTGKITDGNILDAQNFTAMRIASSYGHTRIVELLLRYETILNISDQEKVEAMVEASWQGCESVVELLLGPKGNVAVDALNSHGMTALHHACWGKIENMQSLDDLQWIGSDGLTQDERRDPKYQCCRHASVVRLLLERGAKPDFKSTSGTPPLNFAAETGDPERIRLIIEGIRGEQVMEYALNGETVLGVAFGEKNPEAAMRAILSSSKLTVADFGSETKERDALIWAAGSSKTHDVAKLLLSKSRSITDTRAVPSESAGWGAIEWAVFLDRPDILWLLLASTPSSQQMDITLNRAMFLAAEGSRITQSQTADQDTEPSENKAESGTGENGSQDKLGNKQVLIDILHDPPFGLLQRDSETYNHPVFDLGLTDVLDQFKSTVMQLYQDQNESSLIRRYRTVREVIYETGPRNIMKQTIQDLRGIIGTSGSTPSMVNIEARPSFTWIHLPAANMTWMNDIVQRILKDDDYSTRDYRNITSFLQGSWGEIPDKTSPSRMMRPRAITTNTNLSGLAQNSTRTGRDRGYHKDEEDMKANMERENETDGAEHDTRNNDGNAAAKGPGQKDPKMDGGEERGGTAPSGRTKTVIPASAIYMPYLAFSTQHRDDIDLGPTESPNSDKAKLEQVKKASEIHKNHMQCYGGSVVHGSPTLDEWYYHFAEDPESTQERLYRNQSQVVNKNLQVDANQLAHWPLLRVNQLWIWTIDNKWLITASSEQVVDGKDELLKGILHHLRKQVETQGSHSQPSSVSAMGNFIVNYCIGSYERQRETENRDPKAESQLSIRQIYSNEINTIGRNETAVFDEFNDKARKRRNELHPRPENQVSAYNDIKETMKKAEMLYCDIKDIRDELSIIKSVAQYQRTVQDQIASNHGTVSNLTANYISNDVREMDNVAIRIQGAQSEVANFQATLSVEQGQQAAKQGRTLMVFTVVTILFLPLSFLSSLFAMDVESFQRSPSWALATIFSVSFAFFIPLATYAIYSNEISNLIRSRKHKDSEDVDEQLVRRGTGLSVRRTFNSATLQPAGSPRYSVSDASGKNHTGRESYQLRARNTYNGKNEDGSASIGSKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YIU9</accession>
    <name>A0A1C3YIU9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T05653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YIU9"/>
    <dbReference type="STRING" id="229533.A0A1C3YIU9"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05653"/>
    <dbReference type="eggNOG" id="ENOG502QYJC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YIU9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="434" mass="48987" checksum="7827EBDC44E66CA3" modified="2016-11-02" version="1">MAPGSPPPAVLPQRRHDLDVAKQQLVCIVTIVATLFVLCPERYQLYRNLAVIPILAYVTSRIFDLVISLNEKWDRAPAVVKYFVPVQIPEIAPPSEQIVGLVKNQVATAGDKLHHFSLQLRSMVRALVDWILRQTGSGSFSKDTPGSDAKTPKKPKQDRWVAVLVTTPILEERNPFQIDADLDSEILELISWDSSELSPNLAIILSSTFKVQLTLCLIPRSIWYSRKTLLEKFTTGLYWSHQPGHSHCQGQQWDEDRIKAISRVQYIGTVNEHKDIVKVNEHFDSLRKGWNDVNTYWNDVDYAILLSFLLVGKSSTEICKKMFDHFANLRVEYAQRNTDLNRSRAGAALLTLLTGGLAAPVTIPMMMGAGDAAMTMSANDRYLWGERNNMCKELMARHKELEAIIELKDIEINVTKPVTLPPALESSWLADDAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJ90</accession>
    <name>A0A1C3YJ90_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FGRAMPH1_01T07749</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJ90"/>
    <dbReference type="FunCoup" id="A0A1C3YJ90">
        <property type="interactions" value="802"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YJ90"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07749"/>
    <dbReference type="eggNOG" id="KOG1871">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJ90"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="504"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="134"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="288"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="439"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="855"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="336"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SCB64598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="944" mass="102318" checksum="CEBB480624EF014F" modified="2016-11-02" version="1">MSNRHLPAGQNIQGGSGVLGADMVGPGGPRRRQPPPFVPQSQYQQQHHHHQAVNHMYNNNYMNYGQQQYYGYPPQYQTGHYQNAQYHNAQYQGGQYQAAQFQNGQYQNAQYHNAGMPSPGAYMGYQQHYGRSPPVHQFVPMSGVSVPPSFPTRPAQQQSPALPTQPPAPASLPPQTPTSTHSSQIIPTSTPPVTQETEPAPPAPPVAPAEPPRQPSPVPVPAAAAVPAPVHVHVHIPVPQEPFRAPLPWYSHPDEKFPVRTKRPGRWRKRLNADSANVSLPAIDQHNAAAEQASVPEASSTEPSVSALTPATSTAPSEAAATPRQSSETPASVQQRSRANTATSATSTSTNRPATRSSATPAPALPSLPKANTKDAKPARAEKPVNGDAATESAPEQEVTAEDSEKPAESESTAAGPAPAVKAPPSSWAKLFSKPASAAAGKTEESNGAAPVDTVANGRATESPAGTPNGAAPSFSKVNANSVAEAIHTFHVGLADQVSFLEPRGLINTGNMCYMNSVLQVLMFCLPFYDFLNQISKRAVHSFKSDTPLIDAMIMFMHEFKTIKSAAGVEPLRLALKNEELERYGEPFTPEFVYEAIRQLPRFASMRRGHQQDAEEFLGFLLQSLDDECTTVLKNFTPDEAEHQLSAGSDAGGADDWLEVGRKQKSAVSRSSGSNSSSPISRIFGGLLRSEFRVPGLKDSITTEPYQPLQLDIGSSDVRNVVDALRGLTRPERLQGDFNSPRGKEVTATKQVFIESLPPVLILHLKRFQFDAEGNGTVKIWKKIGYPLELEIPREALSRQKRQTLGEEGMPKYKLISVVYHHGKNASGGHYTVDVRRQEGREWIRIDDTSIRRVRSEDVAEGGEEEEVKNTRKDGSSLGNRFGAVLDEDAGDDDGWSKVTSPAGGAKKWSSVANGTNGTPKAAKPIKDNIKDNKVAYLLFYQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJI1</accession>
    <name>A0A1C3YJI1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T17217</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJI1"/>
    <dbReference type="STRING" id="229533.A0A1C3YJI1"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJI1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF189">
        <property type="entry name" value="CYTOCHROME C MITOCHONDRIAL IMPORT FACTOR CYC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SCB64707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="258" mass="28147" checksum="C084FE93B41F538F" modified="2016-11-02" version="1">MRFYIRAVGDGEMSNYLGRRRVGDDVFLRGPHVGFELAERLGEHSRLVFLAGGTGVVPGIQAAKAVLEANEKSSVDLLWAVRKREEVQNSAFPSSSSWKFWQGKRPTALGLEVESPSPVTKRLQDLKKTYGDRLRIQVVVDEEGTRFQDKDINSTITASPGTVASFNAGCRFHDQAMHVHASEFALSEGPGCVCEPPAGTTPGKNLFIVSGPDGFIEHYAGPKIWLGGHQTQGPIAGVAGHLQRQNPALARDWLVLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJV0</accession>
    <name>A0A1C3YJV0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T16447</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16447"/>
    <dbReference type="InParanoid" id="A0A1C3YJV0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SCB64660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="448" mass="49598" checksum="D7547420FC29CAB4" modified="2016-11-02" version="1">MKRQAPCEPSDESQQARKRGPSSRPPRASQACRSCAASKVRCDDLEICRRCLKRGVPCIRPTPVGQGYRSAMGEAPCVLSNLSHSQQCSDTQTMDNLGDILLTDTTEWFKNLSFHAEFDTSFLLPLPFIDLSGYPDEILIENPTDLTTMSSESMLPQEKTIFDEAVIAHSSTLGSWKPTHEDYLGAARASLYVPLDEQVLLEEGLGHLNSTVIGGCLSSARRDEIIVAMIDGTQTAQTLLAVRMFPSVEILDRFLKIFLTSQETSALAFVHIPTFDPSTCSLSLLMACIVAGATLSPIASARKFGLGLFDVLRLYLAASAEKQNTLTRDLSYVQSLMILSETGLWSGDKRISEISDFLSELTANMLRHAGRFVQHSYLNPILMLEGPLGELDAVWIRWAQQESLKRFSTPPTMYTAIRFKEYANTDVTIRGLDAHPRRLSFLVCQVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YK44</accession>
    <name>A0A1C3YK44_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T19951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YK44"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19951"/>
    <dbReference type="eggNOG" id="ENOG502SBFH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YK44"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056539">
        <property type="entry name" value="NuiA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42093">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42093:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23151">
        <property type="entry name" value="NuiA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SCB64903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="203" mass="22597" checksum="5CEED4EBD39FAAE7" modified="2016-11-02" version="1">MSSRTPLRRFNNLNLGSLLRKQDILPRTANFSRPSQRLISISRPLKMSNDDDYMAFLNKANQDTGAGASTQAKAVFKAKDQDAEVPKAIVDVCKKAVYTSDADEPFEEVSLKWQGKNGLPTETEFAKLIDHSSPESAEIQILDPLSWDSHGKYTDVIEAVREASHGNDVRVYQVTRDSTRIEYWVISHADGKLIGAKALSVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKG4</accession>
    <name>A0A1C3YKG4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T19531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKG4"/>
    <dbReference type="FunCoup" id="A0A1C3YKG4">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YKG4"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19531"/>
    <dbReference type="eggNOG" id="KOG2961">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YKG4"/>
    <dbReference type="PHI-base" id="PHI:5772"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000165">
        <property type="entry name" value="HAD superfamily phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027706">
        <property type="entry name" value="PGP_Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010021">
        <property type="entry name" value="PGPP1/Gep4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01668">
        <property type="entry name" value="YqeG_hyp_ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09419">
        <property type="entry name" value="PGP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SCB64871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="216" mass="24172" checksum="622E406BFA118590" modified="2016-11-02" version="1">MMNLNLSASLNITRLIFKPSLCLPHHTVSTFNDLPIPLEKGLQQDGRKVEIKAVVLDKDDCFAYPDSIEVYESYKTHFEKLRLAYPGRKLLVVSNTAGATSWDKNLKLAAEVEKNTGVMVLSHSVKKPGCGQEIMEYFKKHPETGVTNPGHVAFVGDRLTTDMMLANMTGGWGFWVKDGVIPLEKKSIFSRLERPLASFLIARGLHAPEPRSIFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKM9</accession>
    <name>A0A1C3YKM9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FGRAMPH1_01T20325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKM9"/>
    <dbReference type="FunCoup" id="A0A1C3YKM9">
        <property type="interactions" value="828"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YKM9"/>
    <dbReference type="eggNOG" id="KOG1749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YKM9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003254">
        <property type="entry name" value="PRK04211.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SCB64936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="169" mass="18608" checksum="31900F5D3374E26B" modified="2016-11-02" version="1">MFNFPQPSKLPSPTRRRYTDRSAKMAGGKPRGLNAARKLRTNRKDQKWADLAYKKRALGTAYKSSPFGGSSHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKVTAFVPNDGCLNFVDENDEVLLAGFGRKGKAKGDIPGVRFKVVKVSGVGLLALWKEKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKU3</accession>
    <name>A0A1C3YKU3_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T23645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKU3"/>
    <dbReference type="FunCoup" id="A0A1C3YKU3">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YKU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23645"/>
    <dbReference type="eggNOG" id="KOG2278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YKU3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SCB65159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="340" mass="37166" checksum="08041D1008E0AAC9" modified="2016-11-02" version="1">MSFIFTSKLKPTFHHFPCTSYRSSAIAAKASLPTSQPHHKVFFSQRINNTMADNAAREDALLDVEDKVHDKHSKPRGGKGRGKSGGGGGHGREVQVSKALSRLLRHQAANAGIQLDDEGFARLDTVLAWNPLRSLKVTFDDVQTAVSTDGKQRFTLKPNPDTNPSLDTKSTSPADYLIRANQGHSIKLESANLLTPVTVEAGNVPNRVLHGSFFYFWSAIVETGGLKPMNRNHVHCSAGTPEEGILSGMRRDAELIIEIDMEESLKDGIKWWLSDNGVLLTEGDEQGILSTKYFKLVTGRNIDVGVLWQDGQWVSDLPRGTKISPPFGKRGGRGGRQGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLI0</accession>
    <name>A0A1C3YLI0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FGRAMPH1_01T24969</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YLI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24969"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YLI0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF10">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="193"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SCB65274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="816" mass="91714" checksum="357A1A30A0DD96A1" modified="2016-11-02" version="1">MTQDMVGSTSSNKRQKVDHNGGANLRMCHHCGKSFKRTEHLERHVRTHTKEKPFLCHCGASFARRDLLTRHQRIAEHQGDAPSPGSVPVPGPGPGALTQSRQNSISSHNVDPCFCARPQQAMQVPVAVPAPLPLAVQEQTQRPPNIDAGQFVPNFFSPQMLDGGVDFDTHFREFTSFLDGVGLSAEWSPFFSDRDRYQDPVDPELRDEDNETTSPQQGAPTRAGTPFSSWLPSVTGNRINNYVSDTDNPRAVDPETRLFKVTEEQRSKVKASIQDFSHLLDPTFCVPSRHSLTRYITSFFGGFHSHMPFIHVPTWQITEHSPELIFGIAAIGAQYCFERKASERLFFAGKALVLERLRRNAELLDMSAIPRIHTVNSAKQSGRDSNAPDKESQVETIRALVTLMGFSTWEPKAAMVQESFVLQGILTQALRNAGLEDVDELVSSTPSSHPHDSNALWHDWRTWAKQESCRRSKLICFSFLHTHSIAYNVYPTLRSNEVGLRLPCSTKEWKAPNAASWRAAAREVQEPQLFFREALSLLLNNKSESAPLFPIPTPLGNYVLLHGLLQRIHIVRDLSLPITSSSASLPSEEVEKLERGLRSWTSCWQQAPESTLDPNNENGPIPFTSSSLLALAYVRIYLHLGPFRQLETRDPQLISEAIASSPDIERSDGIIAALLYATHMIGIPVRLGVDRVARSQAFFWSVRHSLSGLDCAVLLGKWLSKLAETVSESPLTDSEDRILHWVRCIVEEAYTVVDFEQSHDDQEITNLLDFTDPRNLSLAVLKIWAHFFKSNTQWLFINIIGVGLEKYREMLIQKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMJ5</accession>
    <name>A0A1C3YMJ5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T11887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YMJ5"/>
    <dbReference type="STRING" id="229533.A0A1C3YMJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11887"/>
    <dbReference type="eggNOG" id="ENOG502SRGF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YMJ5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF11">
        <property type="entry name" value="CONCANAVALIN A-LIKE LECTIN_GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SCB65736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="387" mass="42576" checksum="3D3B055BD9937C5C" modified="2016-11-02" version="1">MEPLSKTAHQTTVTVQSNMRLIALIGSALTVLPDLVSGQTDQKGTVCGNQRFGNLNDSLSYYPNAWNKKSPKSGFVCLKVDNSTPAFDATWNWDKNIQDVHSFPYVRFNHPDLPIRLKDLESIRLSTDWIYTPGNPSQPPQDFSSSKWAENKAQLNSKGMQANAAWDFFLDDDRNRTLYPQVAAVEIMVWLGSVGDPWWLGRANNSIISTVTLGKTDFSLFYGRNSGGTHVFTAVTKDNTDILSFDENFYPLFKFVLQQAYKHIDEPNDLPKDPWLGIIEFGTETWLSNGNATFTAANFAMDLKSNVTDNDHNSTGSGNGGNKTSDGDRDKGDDASKGNEGDKGSGNDNGDNSTSKGDEEDNARRLMNNSVLGYVVTAALVISAVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMK0</accession>
    <name>A0A1C3YMK0_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phytoene desaturase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Carotenoid biosynthesis cluster protein B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phytoene desaturase (3,4-didehydrolycopene-forming)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">FGRAMPH1_01T11971</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="21">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>15-cis-phytoene + A = all-trans-phytofluene + AH2</text>
            <dbReference type="Rhea" id="RHEA:30603"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:27787"/>
            <dbReference type="ChEBI" id="CHEBI:28129"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:30604"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>all-trans-neurosporene + A = all-trans-lycopene + AH2</text>
            <dbReference type="Rhea" id="RHEA:30623"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15948"/>
            <dbReference type="ChEBI" id="CHEBI:16833"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:30624"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>all-trans-phytofluene + A = all-trans-zeta-carotene + AH2</text>
            <dbReference type="Rhea" id="RHEA:30607"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:28068"/>
            <dbReference type="ChEBI" id="CHEBI:28129"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:30608"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>all-trans-zeta-carotene + A = all-trans-neurosporene + AH2</text>
            <dbReference type="Rhea" id="RHEA:30611"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16833"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:28068"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:30612"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YMK0"/>
    <dbReference type="STRING" id="229533.A0A1C3YMK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11971"/>
    <dbReference type="eggNOG" id="KOG4254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YMK0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016166">
        <property type="term" value="F:phytoene dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000171">
        <property type="entry name" value="zeta-carotene-forming phytoene desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008150">
        <property type="entry name" value="Phytoene_DH_bac_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF1">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00982">
        <property type="entry name" value="PHYTOENE_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
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            <end position="571"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="574" mass="63271" checksum="2184E4D29D537C5C" modified="2016-11-02" version="1">MSDIKQQQKSVIVIGAGVGGVSTAARLAKAGFKVTIVEKNDFTGGRCSLIHKDGYRFDQGPSLLLLPRFFHEIFQDLGTSLTAEGVELLKCEPNYNIWFGDGSSFEMSTDLTKMKKAIEAVEGIDGFERYLGFLQESHRHYEVSVESVLRRNFPSILSLARPEVLFNLFNIHPLESIWTRASKYFWTERLRRVFTFGSMYMGMSPFDAPGTYSLLQYTELAEGILYPRGGFHKVVEALVNVGQRLGVEYRLSTGVKSISIDQATGKANGVVLENGTHLPSDIVISNADLVYTYNNLLPKTSYADSLSKRETSCSSISFYWSASKIIPELNAHNIFLADEYQESFDSIFKEHLIPTQPSFYVNVPSRIDPSAAPEGKDAVVVLVPVGHLLSDSAGTHRGASKSGSSNITGGGGQDWEKMISLARDTVIKTMKARIGVDLAPLIENEIINTPYTWQEKFNLDKGAILGLSHSIMNVLAFRPGTQHSKYKNLYFAGASTHPGTGVPVCIAGSKIVAEQIMMDSGFKKHQIPWAQETSKSPKSGLDKLQDSSLTLFQGFLGALVALLLAYYYMFIAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YN13</accession>
    <name>A0A1C3YN13_GIBZE</name>
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        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
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        <name evidence="4" type="ORF">FGRAMPH1_01T14365</name>
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    <organism evidence="4 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="SCB65895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008687623" evidence="3">
        <location>
            <begin position="21"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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            <begin position="242"/>
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        </location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SCB65895.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1RAV3</accession>
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        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
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                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316334.1">
        <property type="nucleotide sequence ID" value="XM_011318032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RAV3"/>
    <dbReference type="STRING" id="229533.I1RAV3"/>
    <dbReference type="EnsemblFungi" id="CEF72610">
        <property type="protein sequence ID" value="CEF72610"/>
        <property type="gene ID" value="FGRRES_00642"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00642"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01619"/>
    <dbReference type="eggNOG" id="ENOG502RYN9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032571_1_1_1"/>
    <dbReference type="InParanoid" id="I1RAV3"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="PANTHER" id="PTHR36182">
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        </location>
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            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF72610.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF72610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="465" mass="45705" checksum="4D7CB28D8D1629D8" modified="2012-06-13" version="1">MHFNSFALCLGLAGLAQAHMEMISPAPFKSKDNPHAGSDVDYSMTAPLEASGGNFPCKGYHSLFGTAQGASVADWDAGSQQTMKITGGANHGGGSCQASLSFDKGKSWQVIHSYIGNCPAAGTSSFDFKVPSDAPSGEAIFAWSWFNQIGNREMYMNCAAVTIKGGSKRASAMSNRPAMFVANVGNGCTTEESSDLEFPDPGPDVSNDSQKTAGPKGTCAKAGSGGGSGSGSGSGAAPSAAPSAPADNGNNGGNNGAAPSAPAGGNDGSYNPGNDGGSGAAPSTPAAPPAPTKPASDTPDMYVPSSSSATDSGPNSQTSSPGGVFVTAPQPAESTAAPSAPSAPADDGAGSSTLLTMTKPAPAAPTSVVTPEPAPSAPTPPAAPSAPDTGAGAGAGGSGTEEKAGSACTEEGQWNCIGGSKYQRCASGAWSVVQSMAAGTTCSGSKTQAMAFGFGRKLAFRFRRA</sequence>
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    <accession>I1RD30</accession>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Sordariomycetes</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317326.1">
        <property type="nucleotide sequence ID" value="XM_011319024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RD30"/>
    <dbReference type="EnsemblFungi" id="CEF73661">
        <property type="protein sequence ID" value="CEF73661"/>
        <property type="gene ID" value="FGRRES_01517"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01517"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03711"/>
    <dbReference type="HOGENOM" id="CLU_1835347_0_0_1"/>
    <dbReference type="InParanoid" id="I1RD30"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        <location>
            <begin position="1"/>
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        </location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF73661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="140" mass="13757" checksum="BB38019CA92B8FD5" modified="2012-06-13" version="1">MGDTYNITVTGGSFNQYSGGGGGGGGGRGRGRGRGGFPTSRRQAKKQLRRAEWALRRIESRGGGDTNSGSGGGDDTNSGSGGGDTNSGGGDNDTNSGGGDGDGDTNSGGGGDNSGDGHVANPLGNPWVGDADDTNMELWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>I1RDG9</accession>
    <name>I1RDG9_GIBZE</name>
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        <submittedName>
            <fullName evidence="10">Chromosome 1, complete genome</fullName>
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        <name evidence="11" type="primary">FG01665.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T04053</name>
    </gene>
    <organism evidence="10 12">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
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            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat striatin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317490.1">
        <property type="nucleotide sequence ID" value="XM_011319188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RDG9"/>
    <dbReference type="SMR" id="I1RDG9"/>
    <dbReference type="STRING" id="229533.I1RDG9"/>
    <dbReference type="EnsemblFungi" id="CEF73834">
        <property type="protein sequence ID" value="CEF73834"/>
        <property type="gene ID" value="FGRRES_01665"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01665"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04053"/>
    <dbReference type="eggNOG" id="KOG0642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009046_0_0_1"/>
    <dbReference type="InParanoid" id="I1RDG9"/>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="PHI-base" id="PHI:1628"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="9">
        <location>
            <begin position="32"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="550"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="748"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="226"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="306"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="566"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="693"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="51"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="567"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="592"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF73834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="827" mass="89897" checksum="45764DFEE7DA6502" modified="2012-06-13" version="1">MGPNAGNGVGGMEMGPMMQGNGSNLPQATEYTLQGVMRFLQTEWHRHERDRNSWEIEKQEMKGRIANLEGQARRADATQRVLRKYVTMLERKVKEQTAQLQGQEAVDAETTAKNDRAAKIQEKLRSTLEDMPVPGVDGVNYEKLDRGDEEAQRQDLKTFLDQCQSEFMYLMITPANPQPPRESPPLPIMEDLREVEAFGMPAPQPMERQFQLPTRNAQNHVQEMNSRMPQQNHVPHQQNQQQHFTQKQQELQPQPMVRSSAEHPPVMYQNNNDWPAPVSVTSRPVEEQVTPANHAAEVLGGMEDSAELREKHSAPPETDGWDFPEGTFPEPGNSQSNQSQPNRPDTDAFPAADNLPKSPTRRDSSHRRKGSMSRRRSADHELALAAQKAESGNFKLRFGLRGHLDTVRTIIFSGGGSPGEPEICTGGDDGMIKRFHIPRLDGHAGSLAHTASDLDVTANFTHRGHSGAILCLTSWSPSPNFSTGGRATGDGWIFSGGQDATIRVWERGRVDPKATLEGHTDAVWAICVLPATLGQIFGSSSPYGNTDRILVVSGAADGSVRLWSVSAPPQLSSPQPGTNRAMTGRGGRVRGNSMSSGSAFPNTPQATIASNSPFNHTLVHNIARSDGSTASPTCITPLGTTGESFVVSYSDAAIIVYDTRTGEQIGTMDSSETYDQTIKTSVNAVVATTLGLDQTNQNHSGEEDAASGATGGGRSMAGSGVEGTIISGHEDRFIRFFDANSGQCTYNMVAHPDAIASLSLSPDGRELVSAGHDASLRFWSLEKRTCTQEVTSHRVMRGEGICACVWSQDGKWVVSAGGDGVVKVFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1RDN9</accession>
    <accession>A0A098D4Q4</accession>
    <name>I1RDN9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG01749.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T04255</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317584.1">
        <property type="nucleotide sequence ID" value="XM_011319282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RDN9"/>
    <dbReference type="EnsemblFungi" id="CEF73934">
        <property type="protein sequence ID" value="CEF73934"/>
        <property type="gene ID" value="FGRRES_01749"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01749"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04255"/>
    <dbReference type="eggNOG" id="ENOG502R0PF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_612553_0_0_1"/>
    <dbReference type="InParanoid" id="I1RDN9"/>
    <dbReference type="OrthoDB" id="2588793at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF73934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="449" mass="52167" checksum="27708741785F6EBD" modified="2012-06-13" version="1">MAAPPQRPTHDSRLAFRLWMVVSGTVVVLLLLSSYYTGILRTPLDYAESKAGDFCRKASDSTENAKPRNCQDPYRRPGYLIVPPEQKDYQQTQWMPFTNKFLDSHPPSAAYPPKQKELIFNDTQVPEEFLEGPEIPKQWMQIAVAEHKRRVKALNNPHATVDDYASMKNAGGLGWLWGRRIVEFGDSVDRYEAKYTCREFDNEMYFPKVHPIEKVPKGICEIPTFNLTFVVFHSAGGFTYRPDWFWYKEMRIIPFEERWKTVWKPHEEPIQGPNGRPDLLLWQNGLWDQRGFQVGGKKHHEPNTTVGIWSRKLVWEELNFFTSRLRTYVQMLVDEFPGTPMMFRTLTYHQHTGMSDAMMPEMDRVGRAMAAKYGHEVFEWARIIQLLGKHWADRTHPAEGAMSWLWGNMVLEYLARASGAGTNAGGEKRYPYFEGWDACHEERLSQGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>I1REC4</accession>
    <accession>A0A098D5L0</accession>
    <name>I1REC4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG02011.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T04855</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317879.1">
        <property type="nucleotide sequence ID" value="XM_011319577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1REC4"/>
    <dbReference type="FunCoup" id="I1REC4">
        <property type="interactions" value="783"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1REC4"/>
    <dbReference type="EnsemblFungi" id="CEF74234">
        <property type="protein sequence ID" value="CEF74234"/>
        <property type="gene ID" value="FGRRES_02011"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02011"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04855"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014571_2_0_1"/>
    <dbReference type="InParanoid" id="I1REC4"/>
    <dbReference type="OrthoDB" id="271164at2759"/>
    <dbReference type="PHI-base" id="PHI:6095"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07627">
        <property type="entry name" value="BAR_Vps5p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06861">
        <property type="entry name" value="PX_Vps5p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000013">
        <property type="entry name" value="Putative Sorting nexin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000022">
        <property type="entry name" value="Sorting nexin 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035803">
        <property type="entry name" value="BAR_Vps5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037868">
        <property type="entry name" value="PX_Vps5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="152"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="533"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="545"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF74234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="558" mass="62338" checksum="5E2BB2CA83797A2C" modified="2012-06-13" version="1">MDVEESPWADSSQASQQASQPEASASASQSSTPAPASSSAPRPSRGPRRLVAQPTRLEAVDDPLGPLGAVPEDNGSAQDAPPVPPQKEQMVIRTIMSQPQQQRRAADPNHIDDEENDGPKAPRAPPPVEAAQPSAVRSSNQPSVSIEQAAKPTFQIYVGDPHKVGDLTSSHIVYSVRTKTTSKGYKQPEFEVKRRYRDFLWLYNTLHGNNPGIVVPPPPDKQAVGRFDSNFVESRRAALEKMLNKTAIHPTLQHDPDLKLFLESETFNVDIKHKERRDPIPTESKGVLGSLGINVGGGNKFVEQDDWFHDRKVYLDALENQLKGLLKAMETMVGQRKMMAEAAGDFSASLHALSTVELSPSLSGPLDALSELQLTIRDVYDRQAQQDVLTFGIILEEYIRLIGSVKMAFGQRQKAFYSWHAAESELQKKKATQDKLLRQGKSQQDRLNQMSAEVGESERKVHQARLLFEDMGRLMRSELDRFEKEKVEDFKSGVETFLESAVEAQKELIEKWETFLMQLDAEDDESVFYRPPVYQQQQQKGGDTAVDRARARIDEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1REC9</accession>
    <accession>A0A098D5L5</accession>
    <name>I1REC9_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FGRAMPH1_01T04865</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317884.1">
        <property type="nucleotide sequence ID" value="XM_011319582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1REC9"/>
    <dbReference type="STRING" id="229533.I1REC9"/>
    <dbReference type="EnsemblFungi" id="CEF74239">
        <property type="protein sequence ID" value="CEF74239"/>
        <property type="gene ID" value="FGRRES_02016"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02016"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04865"/>
    <dbReference type="eggNOG" id="KOG0380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018190_2_0_1"/>
    <dbReference type="InParanoid" id="I1REC9"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034737">
        <property type="term" value="F:ergosterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008204">
        <property type="term" value="P:ergosterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF9">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="259"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CEF74239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="603" mass="68802" checksum="45BC882BB5386222" modified="2012-06-13" version="1">MSSSIETLANGNGHAGEHDHVLRPRPRKPKHSQVSDVVRMTSTSDGEHLMPDNASTGSASAVVLHPSQRMRLHPSSPFPPLENKFAPSNAAVYSPTIEFASRVSHFDPESDYRDFHGFFNLFWIGLAIMGITSMLRNLKDTGFPLRVQIWSLFTVKLWHLAIADFLMVATTAVSLPLNRAARNAKPGSFLDWNKGGIAIQSIYQVVWLTLWIIVPFYFEWTWTSQVFFLLHTMVLLMKMHSYAFYNGHLSQTEKRLHALDNPFSPHDRRPAYQYPSTDLPASVTKGESNSTNAKKRRRQRQKKQEAKQSANGHKSNDEEPINHDLLAPSPVASPSNSADEVDEIREDLARELTSPIGNVTYPNNLTWSNYTDYIFCPTLCYEIEYPRTTHINWINLISKIIATFGCIFLLTIISEDFILPVLLDASKRLDAVPTESSVSEKLLILAETISWLLFPFMLTFLLVFLVIFEYVLGAFAEITFFADRHFYSDWWNSTDWMEFSREWNIPVYSFLRRHVYSASRPRIGRGAATALTFLISAFGHEIVMACITKKFRGYGFVCQMLQLPIVMLQRTRWVRGKETLNNVCFWASMVLGLSMICALYVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1RED3</accession>
    <name>I1RED3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG02020.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T04879</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317892.1">
        <property type="nucleotide sequence ID" value="XM_011319590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RED3"/>
    <dbReference type="STRING" id="229533.I1RED3"/>
    <dbReference type="EnsemblFungi" id="CEF74246">
        <property type="protein sequence ID" value="CEF74246"/>
        <property type="gene ID" value="FGRRES_02020"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02020"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04879"/>
    <dbReference type="eggNOG" id="ENOG502S18W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014251_1_1_1"/>
    <dbReference type="InParanoid" id="I1RED3"/>
    <dbReference type="OrthoDB" id="27214at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056186">
        <property type="entry name" value="PDZ_CPAF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF4">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23658">
        <property type="entry name" value="PDZ_CPAF_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124137" evidence="1">
        <location>
            <begin position="17"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="CPAF-like PDZ" evidence="3">
        <location>
            <begin position="173"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Tail specific protease" evidence="2">
        <location>
            <begin position="389"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF74246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="737" mass="80030" checksum="9CA1D682A1E31FA4" modified="2012-06-13" version="1">MIIPTSLLAFAGVSFAALEPRQIMHQARHQPSFITSRDLSDAKSAPCKFISKTYEEANPEKGNPVILAIPPSVGIACLKSVPLDKKRDLELLDYLEPLIGFQSTLEILADPPEEYLFPGVDVLGGFDTIRSKLENNKYKTQYEVMTDLRSIFASAYDGHFDYPPALLNAFVYVRRGIDFESVSSNGIRLPYIFSRIDTSRGDHGLLDYTPSAIKSIDGIPIVEWLEEDASRLTAGAQDPDAQYNALFSSVPRSAAGSSASTLVTQYEIPDTYTIVFHNGTKKVVKNEIIVLPTADLSGIESGEDFHQYIEVTPTNMTSEEPANERRSTKTQESSKFIPGYPIPVVKHSANSVAGYFLQGKGYEDTAVLSILSFIPLGLDLTNPPPGFTLTKFILEGQAVVLEFIRKAKAAGRDKLIIDMSANGGGSVVLAQSIYRLLFPDGKFTGWDRYRANAALEAASEASYDSLVATLITVSEHYPVGVDGKAITTGKDFFGPYTVKGENVTAAFQIDKTVPWEPSIPAYFNGFDPETKPLVEEAPWKPEDILIVTDGICASACGILTGLLTRNYNIRTLALGGRPLDHAMQAMGGVKGTLLNFNQDIVSAMALVRDGAGTDKEALSILSDASASIPSASNPPLLPLPSAGRVNSLNGYTEDNLKGYPVQFRYEAANCRLFYTQLMAASPVAVWRRARGVAWNEEPCVPGSTTGKNGIIGDKTLKYNSRVRSRASGIKGPGMLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1REL7</accession>
    <accession>A0A098D5W9</accession>
    <name>I1REL7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG02109.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T05085</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317985.1">
        <property type="nucleotide sequence ID" value="XM_011319683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1REL7"/>
    <dbReference type="STRING" id="229533.I1REL7"/>
    <dbReference type="EnsemblFungi" id="CEF74348">
        <property type="protein sequence ID" value="CEF74348"/>
        <property type="gene ID" value="FGRRES_02109"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02109"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05085"/>
    <dbReference type="eggNOG" id="ENOG502SD7M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099924_0_0_1"/>
    <dbReference type="InParanoid" id="I1REL7"/>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124128" evidence="11">
        <location>
            <begin position="20"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="12">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="90"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF74348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="250" mass="25730" checksum="F14121ED54065F14" modified="2012-06-13" version="1">MRKPTAAQLALLMASVATAADTTCAIDCFQGLITNGPPADCKEATNYLCFCTMPTLQENFLKCADTSCGKDTSAALTWANELCAKLGKPIDLGPGDGAPKTDATTTIDATTAVETPASTTDETKQTTTAETTVPEAVQTTATETEKTYSKAEETSIETSVPSGTSQETSQDTPETCITETTMTKTETTFAKATTTEGASVTTDEDGFVGTVTGSGETATSSSDAEVNAGSITTPGLLAVAGVFAALWQFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I1REN3</accession>
    <name>I1REN3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG02126.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T05123</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318004.1">
        <property type="nucleotide sequence ID" value="XM_011319702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1REN3"/>
    <dbReference type="FunCoup" id="I1REN3">
        <property type="interactions" value="952"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1REN3"/>
    <dbReference type="EnsemblFungi" id="CEF74367">
        <property type="protein sequence ID" value="CEF74367"/>
        <property type="gene ID" value="FGRRES_02126"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02126"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05123"/>
    <dbReference type="eggNOG" id="KOG2496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022620_4_1_1"/>
    <dbReference type="InParanoid" id="I1REN3"/>
    <dbReference type="OrthoDB" id="340962at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin C-terminal" evidence="3">
        <location>
            <begin position="158"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF74367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="349" mass="39809" checksum="66D059ACC9B631C4" modified="2012-06-13" version="1">MATEDERYRQSSQFRLWSFSKANLQELRAKTNSLAREQIAPRLATNPPPDFLTPDEEIRLVKFFTVELIRAAQFCELPTEVRATAAIFLRRFYVTNSVMTYPATDLLKTSLFFGCKAEGFFYKLNAFSEKFPNTTGEQILAGEFLLCQGIRFAFDVRHPFRALEGAILEFRRRLPDEETRINKAHAQAREILKFSPLVTDAYFHYAPSQIMMAALSMVDHGLLDILIPSPGQGGNASQDAVFANMRDKILEAVASCRKMLEEEPPERMTDYWGTPEIVKAMKPLRKKLQKCRDPDRANLVNLQRARREQVMNKEKKAAEGGEDGTVFGDESRETKRVKLENADPFGPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1REU0</accession>
    <name>I1REU0_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
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        <name evidence="4" type="primary">FG02191.1</name>
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    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318078.1">
        <property type="nucleotide sequence ID" value="XM_011319776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1REU0"/>
    <dbReference type="FunCoup" id="I1REU0">
        <property type="interactions" value="571"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1REU0"/>
    <dbReference type="EnsemblFungi" id="CEF74444">
        <property type="protein sequence ID" value="CEF74444"/>
        <property type="gene ID" value="FGRRES_02191"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02191"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05279"/>
    <dbReference type="eggNOG" id="KOG2407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021459_2_1_1"/>
    <dbReference type="InParanoid" id="I1REU0"/>
    <dbReference type="OrthoDB" id="331263at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124134" evidence="2">
        <location>
            <begin position="22"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="526"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF74444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="582" mass="65104" checksum="26E3B21E139840B5" modified="2012-06-13" version="1">MRRFLAYLLLAITNGFALTSAAASGYHEQLTLRPLPLSQLLASFNFRANTSIADFEAHNFRLFPRSLAQILQYAGTRELHLRFTLGRWDAQSWGARPWDGTREGGTGVELWAWLDAETDAEADEKWLILTNALSGLFCASLNFIDETRTIRPVMSFQPDGHHSNSSLANTRLLHGVLPHEVVCTENLTPFLKLLPCKGKAGIATLLDGHKLFDASYQSMAIDVRPKCDTDGECFLEMEETVDMVLDINRSKRPQNNPIPRPPPSHELLCDTSKPYHSDNTCFPADSLDGQDWSLSQVFGRSIKGTCPLTDPDIPPVCVQIPQSRDIYTTEGAREIRSQDGNSRCYNLDANSELALMLVKPESQDEDKILNKPETPLLYADRSFNGHGQEHGGVQAILSNPSDTDVEFVYMESLPWFMRIYLHTLSARIADAPLSNSSDLIKEIYYRPALDRARGTQLELRMRIPPHCTVFLTYDFEKSILRYTEYPPDANRGFDIAAAVITTLEPKVLNIRTTTLLLYLPTPDFSMPYNVIIFTSTAIALAFGGLYNILVRRFVGADEAQGMALKAKIIGLIARLKGKVGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>I1RF24</accession>
    <accession>A0A098D6H4</accession>
    <name>I1RF24_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">FG02287.1</name>
        <name evidence="20" type="ORF">FGRAMPH1_01T05519</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="21">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="22">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="21">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="20 22" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="20">PH-1</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318195.1">
        <property type="nucleotide sequence ID" value="XM_011319893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RF24"/>
    <dbReference type="SMR" id="I1RF24"/>
    <dbReference type="FunCoup" id="I1RF24">
        <property type="interactions" value="406"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RF24"/>
    <dbReference type="EnsemblFungi" id="CEF74564">
        <property type="protein sequence ID" value="CEF74564"/>
        <property type="gene ID" value="FGRRES_02287"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02287"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05519"/>
    <dbReference type="eggNOG" id="KOG0136">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014629_3_1_1"/>
    <dbReference type="InParanoid" id="I1RF24"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="UniPathway" id="UPA00661"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000006">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000015">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 14" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="18">
        <location>
            <begin position="33"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="17">
        <location>
            <begin position="149"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="19">
        <location>
            <begin position="290"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="16">
        <location>
            <begin position="512"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CEF74564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="696" mass="78339" checksum="F3F8978675CDE2F2" modified="2012-06-13" version="1">MPPPNPDWVKALTPSGPQGSELIAKERAQSDINVDQLATFLFTKEVLERNAKILKILQEDPVFDKSQNYFRGRTDRLEAALARGKHLKRLRDKHNWTEEEHHVANDLISEPTPYGLHSTMFLKTLEEQGTPAQHELFLEKARNYEIIGCYAQTELGHGSNVRGLETTATWNPEDKTFTMHSPHLTASKWWIGSLGKAANHAVVVAQLILNGKSYGPHPFVVPIRDMKTHEPLENIHVGDIGPKFGYNTMDNGFLLFNHVKIPHVNMLNRFSGVDPETSKYIRPSNPALIYGTLTFIRSSIVFQSGSVLARGVTIATRYCAVRRQFQDRDADAGEVGENQVLNYTMVQHRLLPLLASAYALHFTGRSMINLYNANQKRMAQGRERDNSKRAPGPEELSPGSDHLADLHAISCSLKAFASTTAAEGLEVCRRACGGHGYSAFSGIGSWYADYLPTVTWEGDNYMLTQQVARYLLKSARAVLAGKAPDNGISRIFKEFIRRQDIGAAFDVLDSDQDLVDAFAWRVSFLTFEALKHRDEEKQSWNSLLIDFWRLSTAYAQYQVVKNFHEALKEESTKTSLDANTLTLLHKLFELFALHHLQSSASEFFTSAATTVRQIQLARTKRTLSLLDEVRPHAVRLVDAWSFPDWQLDSALGRADGKVYEDLFRRASEDNPVNDIVFDSNPASDILFRKNGPKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RFE4</accession>
    <name>I1RFE4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG02418.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T05807</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318337.1">
        <property type="nucleotide sequence ID" value="XM_011320035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RFE4"/>
    <dbReference type="EnsemblFungi" id="CEF74708">
        <property type="protein sequence ID" value="CEF74708"/>
        <property type="gene ID" value="FGRRES_02418"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02418"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05807"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_13_2_1"/>
    <dbReference type="InParanoid" id="I1RFE4"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF74708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="290" mass="32031" checksum="14EB4ADBBC9589DC" modified="2012-06-13" version="1">MSYSVKGHFAIVTGGGSDLRLRPEAATTIREYPHPTPDPSKPSAVFCETDISDWSQILVLWKTTLERFGRIDIVVNSAGVYEPPSSSFWHPPGISPLAKDVEDAQVGQYQTFAINTIGPIRLSQIAIDYWQQNPDVQGNMLFIASMGGYLHSMQTPLYFASKAALVSMVKSLSGLKRVLGIRNAAICPAAVFTPIFEQDYCRDRLGPDSVALEPEHVAELALQVLQEPQYGDGNIMEIMMIGSKEEPSVNVREVQLEALYPTMGSSVMGERAIAEELKFFDRVKEKGMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I1RFM6</accession>
    <name>I1RFM6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">FG02506.1</name>
        <name evidence="19" type="ORF">FGRAMPH1_01T06015</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="20">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="21">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="20">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="19 21" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="19">PH-1</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the C-terminal section; belongs to the AIR synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the GARS family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318439.1">
        <property type="nucleotide sequence ID" value="XM_011320137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RFM6"/>
    <dbReference type="FunCoup" id="I1RFM6">
        <property type="interactions" value="1177"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RFM6"/>
    <dbReference type="EnsemblFungi" id="CEF74812">
        <property type="protein sequence ID" value="CEF74812"/>
        <property type="gene ID" value="FGRRES_02506"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02506"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06015"/>
    <dbReference type="eggNOG" id="KOG0237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005361_2_2_1"/>
    <dbReference type="InParanoid" id="I1RFM6"/>
    <dbReference type="OrthoDB" id="2018833at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="PHI-base" id="PHI:744"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000006">
        <property type="entry name" value="Phosphoribosylamine--glycine ligase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000006">
        <property type="entry name" value="phosphoribosylamine--glycine ligase, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000001">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000018">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.600.10:FF:000001">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000007">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="18">
        <location>
            <begin position="113"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CEF74812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="797" mass="84580" checksum="6653C98A8C52880E" modified="2012-06-13" version="1">MADLRILLIGNGGREHALAWKLSQSSRVEQIFAVPGNGGTAGCPKTSNVTSVKAEDFAGLIKFSQENGVNLVVPGPEAPLVDGVEGWFRNAGIPCFGPSKEAARLEGSKTYSKDFMKKYNVPTAAYENFSDYTKACAYVESVDHDVVIKATGLAAGKGVILPETKEEAKAALKQIMVDKEFGDAGDEVVIEELLIGDELSVLTFCDGYAIRSLPLAQDHKRIFDGDQGPNTGGMGCYAPTNIATKELTELIDREILEPTISGMRREQQPFRGVLFTGLMITSKGPKVLEYNVRFGDPETQTVLPLLSADTDLAEIMLACANGYLDNCKLTIENKFSATVVLASGGYPGSYPKGKAMTVQTPPPGCNIFHAGTTLDSTGLKTSGGRVIAINAVGDSLRAAVDAAYAALDNKAIEFEGAFYRKDIAHRAFRSSAQASMTYAQAGVDIQAGNDFVEKIKKAVASTKRPGADAEIGGFGGEVDLSQAGYPQAPIIVGAIDGVGTKLMIAQAMKKHDTVGIDLVAMNVNDLVVQGATPVMFLDYYGCSKLDLSTAADFVQGVADGCRQAGCALVGGETAEMPGMYQKDDYDAAGCAVGTVTAEAKLPRKDDMAQDDVLLGLGSAGVHSNGFSLARRIVSHAGLSYTDAAPWDQSTTVGESLLTPTRIYVKALLPILSEIKGLAHITGGGLVENVPRMIPESLAAEIEFGSWEIPPVFKWLREAGNVEPLEMCRTFNSGVGMVIAVEPSKANAVAQTLTDGGEKVYRIGRLTRRDQGEACLIHNVDSWKAETTVPSKRKDIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1RFR0</accession>
    <accession>A0A098DA96</accession>
    <name>I1RFR0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG02547.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T06113</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318484.1">
        <property type="nucleotide sequence ID" value="XM_011320182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RFR0"/>
    <dbReference type="EnsemblFungi" id="CEF74861">
        <property type="protein sequence ID" value="CEF74861"/>
        <property type="gene ID" value="FGRRES_02547"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02547"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06113"/>
    <dbReference type="eggNOG" id="ENOG502QQIE">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_012066_2_0_1"/>
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    <dbReference type="OrthoDB" id="415532at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
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        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
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        <property type="entry name" value="DUF4246_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DUF4246_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
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            <end position="30"/>
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    <feature type="domain" description="DUF4246" evidence="1">
        <location>
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            <end position="504"/>
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    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322443.1">
        <property type="nucleotide sequence ID" value="XM_011324141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RHP0"/>
    <dbReference type="EnsemblFungi" id="CEF78075">
        <property type="protein sequence ID" value="CEF78075"/>
        <property type="gene ID" value="FGRRES_03301"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03301"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12545"/>
    <dbReference type="eggNOG" id="ENOG502SP41">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_015092_2_0_1"/>
    <dbReference type="InParanoid" id="I1RHP0"/>
    <dbReference type="OrthoDB" id="5376804at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="58"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="362"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF78075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78075"/>
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    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="414" mass="45983" checksum="D5679CF9DE4472C3" modified="2012-06-13" version="1">MAISNIDQRNDRHPFDSLFDEARRGPYGSMLFLLNVSCNMATIGALITILRLGFALMAQEVISLEPRPVNTTDKNATFGFAHSYNRSLNRGVNGGFKSACEDVTIPTLNTMFCVEDTGKPLPEGEFLHEYRLCNMTTPGGIMLSIQQQFPFFLTTFRSNTTVPTRDESSIGSRSTNLMKFAIYRTERDEDYMPLDADITECTLSLAAYEYTGPKTNGSVFSFDNIQMVELEWSRPASEQAIRRLVSSPTKTGTPDLYFDWIDEMALQDFLQSPTFLLEFVEGESGSLKHGLSAVLGAEANLSNAFDNMATSMTDYVRSGPNMQLATGVRIDTEIFVVMCWYWLVGPGLVDLASLLFAIATIVGDTRKQKVPLWKSSALVLLACQNDADEGVIRGTSESVTELEKRARASKVRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RHT5</accession>
    <name>I1RHT5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG03349.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T12667</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322383.1">
        <property type="nucleotide sequence ID" value="XM_011324081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RHT5"/>
    <dbReference type="STRING" id="229533.I1RHT5"/>
    <dbReference type="EnsemblFungi" id="CEF78136">
        <property type="protein sequence ID" value="CEF78136"/>
        <property type="gene ID" value="FGRRES_03349"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03349"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12667"/>
    <dbReference type="eggNOG" id="ENOG502SMA8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046727_1_1_1"/>
    <dbReference type="InParanoid" id="I1RHT5"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF5">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASE PRCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="8">
        <location>
            <begin position="35"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="118"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF78136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="317" mass="35830" checksum="7451E1FD82A27AB9" modified="2012-06-13" version="1">MSNGTNGTNGAEAQSKFDPNFTDHVIGLMSPETEPRQREILTSLIRHMHDFCREVELKQEEWIIGVNYINSLGQAYKKNRNETWRVCDILGIESLVDEINHKVVTEGGKAPTSSSILGPFWSPETPFRDLGGSVVQDMPKDGQLTFFHGVIRDVDTGKGIPNAVFDMWQASTNGKYDAHDPENQSRHNLRGKFRTDQDGKFWFYCLKPTEYAIDTSGPSAELLRIMGRHPYRPAHIHIMVTHDDYLGVTAQLYPSDDPYLETDTACAVKDDLVLDFKPAKDDPKGATLDVEYNINLASKKYKPDNTMLMQNANQDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RI02</accession>
    <accession>A0A098DJX4</accession>
    <name>I1RI02_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG03421.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T12847</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322298.1">
        <property type="nucleotide sequence ID" value="XM_011323996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RI02"/>
    <dbReference type="STRING" id="229533.I1RI02"/>
    <dbReference type="EnsemblFungi" id="CEF78226">
        <property type="protein sequence ID" value="CEF78226"/>
        <property type="gene ID" value="FGRRES_03421"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03421"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12847"/>
    <dbReference type="eggNOG" id="ENOG502QS9T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006921_1_1_1"/>
    <dbReference type="InParanoid" id="I1RI02"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB-like" evidence="5">
        <location>
            <begin position="45"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="4">
        <location>
            <begin position="226"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF78226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="472" mass="54602" checksum="EC5746FCB676AB3B" modified="2012-06-13" version="1">MAIDTKNPYAFLLQPEQYAPAPVPSLAEWKQLWHVWELVTTKMIRPEALMEQPIPLRNPLLFYLGHIPTFEDIHLTRATDDEPTQPAYYHRIFERGIDPDVDDPSKCHDHSELPDVFPNLEDILHYRERVKQRIASLYENGEAYSDRCIGRALWIGFEHEGLHAETFLFMTIQSHNILPPPDLPRPDFAKLAKGAASRRIQNPWFKIPTQEFTIGYHDPESDEGPDRFFAWDNEREPYKVRVPQLESQGRPVSNGEYAKHLLNVKQSQIPATWHKIRTAGEDEDFTTFIARHSVKTVWGPIPLAQALDWPVMASFDEVKRYAHWAGARLPTLHELRSIHEYVERGRKAPESQVNHQFHTDPRAIFVDLTETNSGFRNFNPTGITHKDYLCGLGDTGGAAEWTGSLFEPQPGFKPMDIYPGYSADFMDEKHMAVVGGSWALHPRLAGRKSFLNWWQTKYVWSWVTFRLVRDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RIG1</accession>
    <accession>A0A098DHL3</accession>
    <name>I1RIG1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG03593.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T13239</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322112.1">
        <property type="nucleotide sequence ID" value="XM_011323810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RIG1"/>
    <dbReference type="EnsemblFungi" id="CEF78423">
        <property type="protein sequence ID" value="CEF78423"/>
        <property type="gene ID" value="FGRRES_03593"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03593"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13239"/>
    <dbReference type="eggNOG" id="ENOG502QUMR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040056_0_0_1"/>
    <dbReference type="InParanoid" id="I1RIG1"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="40"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF78423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="572" mass="64657" checksum="DFD23F7AF2454555" modified="2012-06-13" version="1">MFKIKDFTGMQYSRDGPSIGKHDYEYFNQQYATSSHQVDHDMNPALIVQPKEDNDVVKVVQWAKDNKVSVAVKSGGHQYSGASSTGGKNIQIDLSNTYKDMMVIDAPGIPEDRALVYIGVSNRLQDFNAYLRHNDLFVPHGQCAYVCTGGHGQTGGYGQLGRSFGLFGDHIISIRMVDHNGSIQEVTKKSDSELFYAILGGSPGNFGIITHYTIEVYRGASYMGTVAGPNNFKGPHGLKGLWLYEPKVLSRLLGTIAKMSDEGTAPRGYDLCCSVLSTEFPITMLFPSMQDDTIWQKVQNKIKNALSQEVLNLLNGSFPAVIVLYAQWCPINKTDKYDATVDKWFQQFRDFQKDWKNHTLRIEEFDESMAKLTGKWIFPKAREFDLPYVKRTYATKSQTLQKDGWVDATVKRLDLIYNPQQKLGNDKSDKEGEVYDHCKLSVQIQCFGGQNSRFFANKDNGTSYSWRDSTVVQTLDCFHDPGDQYKQYAVNWQAKNDSIMIGPNSPFSKKDRRVLWGSWGDWDMSKPEIWQAYYEDADKYKRLGKTRARADPDGTFTANPFAVTAVKDGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I1RIJ2</accession>
    <accession>A0A098DHM4</accession>
    <name>I1RIJ2_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9 11">Alpha-glucuronidase</fullName>
            <ecNumber evidence="2 9 11">3.2.1.139</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">FG03629.1</name>
        <name evidence="11" type="synonym">aguA</name>
        <name evidence="15" type="ORF">FGRAMPH1_01T13331</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Alpha-glucuronidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Releases 4-O-methylglucuronic acid from xylan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9 11">
            <text>an alpha-D-glucuronoside + H2O = D-glucuronate + an alcohol</text>
            <dbReference type="Rhea" id="RHEA:20005"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:58899"/>
            <dbReference type="EC" id="3.2.1.139"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 11">Belongs to the glycosyl hydrolase 67 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.139" evidence="2 9 11"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322071.1">
        <property type="nucleotide sequence ID" value="XM_011323769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RIJ2"/>
    <dbReference type="STRING" id="229533.I1RIJ2"/>
    <dbReference type="EnsemblFungi" id="CEF78469">
        <property type="protein sequence ID" value="CEF78469"/>
        <property type="gene ID" value="FGRRES_03629"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03629"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13331"/>
    <dbReference type="eggNOG" id="ENOG502SMKQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007125_2_0_1"/>
    <dbReference type="InParanoid" id="I1RIJ2"/>
    <dbReference type="OrthoDB" id="6501611at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046559">
        <property type="term" value="F:alpha-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02795">
        <property type="entry name" value="CBM6-CBM35-CBM36_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1330.10">
        <property type="entry name" value="Alpha-glucuronidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037054">
        <property type="entry name" value="A-glucoronidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011395">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005154">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011099">
        <property type="entry name" value="Glyco_hydro_67_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011100">
        <property type="entry name" value="Glyco_hydro_67_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39207">
        <property type="entry name" value="ALPHA-GLUCURONIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39207:SF1">
        <property type="entry name" value="ALPHA-GLUCURONIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07477">
        <property type="entry name" value="Glyco_hydro_67C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07488">
        <property type="entry name" value="Glyco_hydro_67M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03648">
        <property type="entry name" value="Glyco_hydro_67N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029900">
        <property type="entry name" value="Alpha-glucuronds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9 11" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="9 11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009997673" description="Alpha-glucuronidase" evidence="9 11">
        <location>
            <begin position="17"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha glucuronidase N-terminal" evidence="12">
        <location>
            <begin position="22"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 67 catalytic" evidence="14">
        <location>
            <begin position="150"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 67 C-terminal" evidence="13">
        <location>
            <begin position="476"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR029900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR029900-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CEF78469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="843" mass="94467" checksum="2910537E9668E7E9" modified="2012-06-13" version="1">MRVSTLLLAFSTCVLAEDGLDGWLRYAPLPAHQVSSHAKSLPRNIRVIGGSKNSPLRSAASELQKGFSGILNIDLKTADSKQTCDFAKTIVVTTVDNLEKACHDKQKHPKLEEDGYWLSTSDNSVKIIGQNERGALYGAFEYLSMLGQGNFKHVEKASNPSAPIRWANQWDNLNASSTHGSIERGYGGASIFFDGIKNVRKDLSRVPLFGRLLASIGINAVVINNVNADVRLFNKENRDGLVEIADLLRPWGVQVGLSLNFASPSVTGDLDTFDPLDKKVIKWWHDLTDGLYERIPDMAGYLVKANSEGQPGPLTYNRTLADGANMFAKALEPHGGIVMFRAFVYDKLDWTDWKADRANAAVEFFSELDGKFDDNVVVQIKYGPIDFQVREPVSPLFSHLRNTNSAIELQISQEYLGQQCHLVYLPPLWRTILDFDMRIDGKKSNVRDIVSGKVFKRKLGGYAGVTNVGLDKTWLGSHLSMSNLYAFGRLAWNPQADPQAVLEDWTRLTFGLDNKVRNAITEMSMESWPAYENYSGNLGIQTLTDILYAHYGPNPASQDNNGWGQWTRATRDHIGMDRTVKNGTGNAGQYPAEVAERFENPDTTPDDLMLWFHHVPYDFKLHSGKTVIQHFYDAHYKGANTAQTFPKLWKSLQGKVDEDRFKHELFRLNYQAGHSIVWRDAISEFYRNLSGIADTQDRVRNHPYRIEAEKMDLDNYHPVNVTPTETASKYVAVYTNGTGTATTKLKFKKGTYNLAVNYYDVARGKATWAVYLNKRLVGKWIGDNEEKLGHWPSDFLDGHSATRMTFEGVKIKPGDELTIIGKADGAEKAALDYISLLPEGVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1RIY0</accession>
    <accession>A0A098DI65</accession>
    <name>I1RIY0_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Dihydroorotate dehydrogenase (fumarate)</fullName>
            <ecNumber evidence="11">1.3.98.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">FG03777.1</name>
        <name evidence="14" type="ORF">FGRAMPH1_01T13683</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(S)-dihydroorotate + fumarate = orotate + succinate</text>
            <dbReference type="Rhea" id="RHEA:30059"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="EC" id="1.3.98.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.98.1" evidence="11"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321910.1">
        <property type="nucleotide sequence ID" value="XM_011323608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RIY0"/>
    <dbReference type="FunCoup" id="I1RIY0">
        <property type="interactions" value="728"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RIY0"/>
    <dbReference type="EnsemblFungi" id="CEF78644">
        <property type="protein sequence ID" value="CEF78644"/>
        <property type="gene ID" value="FGRRES_03777"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03777"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13683"/>
    <dbReference type="eggNOG" id="KOG1436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036010_0_0_1"/>
    <dbReference type="InParanoid" id="I1RIY0"/>
    <dbReference type="OrthoDB" id="14784at2759"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990663">
        <property type="term" value="F:dihydroorotate dehydrogenase (fumarate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04741">
        <property type="entry name" value="DHOD_1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.26.10">
        <property type="entry name" value="Dihydroorotate Dehydrogenase A, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033886">
        <property type="entry name" value="DHOD_1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023359">
        <property type="entry name" value="Dihydro_DH_chainA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF1">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (FUMARATE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0288">FMN</keyword>
    <keyword evidence="10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="13">
        <location>
            <begin position="83"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CEF78644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="336" mass="35883" checksum="3056356BD56B4726" modified="2012-06-13" version="1">MRPPQLIISPPLLNSATPWATDLDDLLAIASSPSTGAITTRTSLINGFNHQHEQHQYLFFDPSSATPSQGTSSDQTRPKDHKAEATSSLNNLGYSPIPLDGYLNFLTEISGRLPHLKKTFVISVTGSPEDIQESYKRIESASKDLPFPLAMEVNLSCPNIPGAPPPAYDGPSLQKYLTLLPSHPSLPIGIKTPPYTHHGQFATLIETLQQAASSISFITATNTLGSCLILQDNENIHMSPQLPGTGVGGMAGPSLHPLALGNVSTLRKMLNQVPELSHVQIIGVGGVRDGDGYRRMRTVGACAVAVGTGLGKQGPAVFKRIEADLKGKWDVTTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJ74</accession>
    <name>I1RJ74_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG03881.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T13947</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321789.1">
        <property type="nucleotide sequence ID" value="XM_011323487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJ74"/>
    <dbReference type="STRING" id="229533.I1RJ74"/>
    <dbReference type="EnsemblFungi" id="CEF78776">
        <property type="protein sequence ID" value="CEF78776"/>
        <property type="gene ID" value="FGRRES_03881"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03881"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13947"/>
    <dbReference type="eggNOG" id="KOG2785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018787_2_1_1"/>
    <dbReference type="InParanoid" id="I1RJ74"/>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="PHI-base" id="PHI:1363"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF78776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="323" mass="36459" checksum="1D17BBD8BBA2EBEA" modified="2012-06-13" version="1">MTSTKPTCSLCDLSFDNSQEHRVHAKSESHVAALRQRAVASGLIDETVDDDHTYSSHTQVTGASHGQPSGSDTETADEVSDEALPEFEPAKCIICTQNNESFDDNVQHMKTAHSLRIPYENHLSVDLETLVWYLHFVINTYRECIYCGTRSRTVQGIQQHMVDKGHCRIEMSEEMLEFYDLEGLKKYKTDNGVAIDSETLRLSSGKLLSHRTAPAPKQPHRQTAQDDTENREYPASLPGTVSPDALTKKDAALASQLARLSVRDQQSLIHMSSSEQRSFLLQRKKELETAQRSERKMRLKTERVNNKTFMKHFQNDVPGPKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJD2</accession>
    <name>I1RJD2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG03944.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T14089</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321723.1">
        <property type="nucleotide sequence ID" value="XM_011323421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJD2"/>
    <dbReference type="EnsemblFungi" id="CEF78847">
        <property type="protein sequence ID" value="CEF78847"/>
        <property type="gene ID" value="FGRRES_03944"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03944"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14089"/>
    <dbReference type="eggNOG" id="ENOG502QUCT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033924_0_0_1"/>
    <dbReference type="InParanoid" id="I1RJD2"/>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF12">
        <property type="entry name" value="PARAOXONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF78847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="432" mass="46691" checksum="903072C7723770E3" modified="2012-06-13" version="1">MPSSKSSIAGPKTLALSALAIGLGVLVARPINRFTTVLGVFRQPANTIVKDGDFVTIADTILCEDLHLHKSSGLLYTACEDSYESRFSWFPGLGVLHDPLTASKSRGSIHVIDPKTFKSKRLEFQGFAGPFTTHGIDVISDPEDDSSVYIFAINHLPHPEYLQHVVDGQSYDKYPGNKAASQIEIFHHKIGSPSVRYVRSVSHPLIQTPNDIVARSPDSLYVTNDHHYREGILRQIEDVYYGGKWSTTIFVKITDATSQDATASLNASVALTGLHNNNGLGHGRTPNEIAIGSAASGDIHLATVHSNNSLQVLETIDFDTAVDNPSWYSDPFSSVNGDSSGYISAGLSKAGDLAKSVGVATGTEPVMVWLAQPKNGKWEKKLLFEDDGKRLRSAATAVLIGIDPKLEGGKKKGWLFVTGFYSQSAIAVKVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJP3</accession>
    <name>I1RJP3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T14399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321574.1">
        <property type="nucleotide sequence ID" value="XM_011323272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJP3"/>
    <dbReference type="STRING" id="229533.I1RJP3"/>
    <dbReference type="KEGG" id="fgr:FGSG_04071"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14399"/>
    <dbReference type="eggNOG" id="ENOG502SBMP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162852_1_1_1"/>
    <dbReference type="InParanoid" id="I1RJP3"/>
    <dbReference type="OrthoDB" id="10013825at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.10">
        <property type="entry name" value="Trypsin Inhibitor V, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021719">
        <property type="entry name" value="Prot_inh_I78"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600:SF1">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11720">
        <property type="entry name" value="Inhibitor_I78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SCB65897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="82" mass="9108" checksum="A8E1E3152E1B2AAB" modified="2012-06-13" version="1">MPLVVPGVNSTSGDKAEEWQNKLIGKKLSDDEASTETVFAKRDLPQETRIIEPGMMVTKDFKEDRLNVHLKDDGTVSHVVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RK03</accession>
    <name>I1RK03_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="3">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pantoate-activating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pantothenate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG04187.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T14691</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321441.1">
        <property type="nucleotide sequence ID" value="XM_011323139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RK03"/>
    <dbReference type="FunCoup" id="I1RK03">
        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RK03"/>
    <dbReference type="EnsemblFungi" id="CEF79149">
        <property type="protein sequence ID" value="CEF79149"/>
        <property type="gene ID" value="FGRRES_04187"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04187"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14691"/>
    <dbReference type="eggNOG" id="KOG3042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047148_1_2_1"/>
    <dbReference type="InParanoid" id="I1RK03"/>
    <dbReference type="OrthoDB" id="2020436at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1300.10:FF:000002">
        <property type="entry name" value="Pantoate--beta-alanine ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000013">
        <property type="entry name" value="Pantothenate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="entry name" value="Pantoate-beta-alanine ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299">
        <property type="entry name" value="CYTIDYLATE KINASE/PANTOATE-BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PANTOATE--BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF79149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="376" mass="41224" checksum="88C969EA78B54A29" modified="2012-06-13" version="1">MLPLRFIRHRSPFTTSVRTMASACSTSSRLETLPKSPIRVLRSVESVRRWRKPHVVEHRSVGLVPTMGALHEGHLALIRAAAKENHHVVVSIYVNPAQFGIKEDLSSYPVTWEEDAKKLAALDRELADDGGNLGRISAVFAPTTPEIYPSGFPGQEIDSKGSFVTITPVGEVLEGASRPTFFRGVATVCLKLFNIVQPERVYFGQKDVQQTVVIRRMVKDFILPLQVVVQPTEREKDGLALSSRNVYLGPRRRAAAIVLPNALHAAAAAYTKDGFYTREDVLGAAHKVIDAFASEQSNLPSTERVVFEVDYVSLADPDTLVEVDEIDPSRGAVLSGAIKMLPVEEAKKGEDLGFSGGPPVRLIDNIILKPLDSKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1RKV4</accession>
    <accession>A0A098DKT3</accession>
    <name>I1RKV4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG04525.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T15513</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321062.1">
        <property type="nucleotide sequence ID" value="XM_011322760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RKV4"/>
    <dbReference type="EnsemblFungi" id="CEF79558">
        <property type="protein sequence ID" value="CEF79558"/>
        <property type="gene ID" value="FGRRES_04525"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04525"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15513"/>
    <dbReference type="eggNOG" id="KOG0742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004471_2_3_1"/>
    <dbReference type="InParanoid" id="I1RKV4"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="671"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="951"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="977"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF79558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1030" mass="117112" checksum="66F73604E4A1EF92" modified="2012-06-13" version="1">MTPPLNSHHVSSSESLSDSASLVHNPNEDERGSPAHNEGSMSLDKEAEASTGASGTISSTKLLIAAQVLEQEAKKLQSLVPNSPTENLNHRLNLAIGLLEEAQRELKQMNTTSQQDKTNSVIEDKTDNPTEGQQDKIACKVKQSSMEKWSLDSVDHTHAIVAYYPSTSLIEIDHDGKKVAERVLDHQERPHRVGLVSESLIQEIDEITGINQDTEPPILLAPPYKLLIRYHEAIGERLAQLEAHLRLDDERSDGTLGPDPQTAKRKEGRPETTAELPLQDASMRNYDGSMSSEMRKRWVERFHHLKLLQEFSDTHLASHHRTYAKIKSGDLEKIAFEDLCFLFTPGDIIYIKERGYEQLAKVYSLTGGQQRKGTWKKEYQRFSDSKEVKKPEGYVESWVRGSWSPLIVDYYTMESDGYYVGPKDHCKQIKHFSGERNITDLAIFPLRFHGKKDEIVERLTERGRKYCSSYGHKSYRGITCPEDDKASPENVFGDVFVDIQDYYRVPERSSLFYDPDPVVKKPALGKLCAVEPDTGETEESTGGTTFHLFDAEVDRKASDDFMLSHQHEVECAQLDSNEVPQGILQLLPHWVPAYFFRSRKHHRVYVSGIQSIDKTDEARDSSFESLVIPDSHRNLLLGLVRNLVLDQESHSESEDDVNRSTQIDLVRGKGQGLIILLHGPPGSGKTSTAETLAAYTRRPLYPITCGDLGTIPDYVERSLSQHTTRAQRWGCILLLDEADVFLSRRDWRDTSRNGLVSVFLRQLEYYSGILFLTTNRVGVLDEAFKSRIHMSLAYPTIRLQQTLDIWKGILDRLEIDNHTKKIKVRFDRSALLAWAERHYKTHETMNTTWNGRQIRNAFQLAISLGHYDRDRQLLATNLTNTQAIASGEKRWTSVRLTTAIFNNIAKKARDFEDYLQATRGDDIEIAKTLSLRHDDEKDDLAESLMAQKDYKRQSGGLLIPRQTNRDKGSSRNISSYESRRPRTSRKEESPAGRRRQKGSQSMREEHSNDESGDEEGGEDDIIDEISSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1RKW4</accession>
    <name>I1RKW4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG04535.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T15533</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
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        <citation type="submission" date="2017-01" db="UniProtKB">
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                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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    <dbReference type="AlphaFoldDB" id="I1RKW4"/>
    <dbReference type="EnsemblFungi" id="CEF79568">
        <property type="protein sequence ID" value="CEF79568"/>
        <property type="gene ID" value="FGRRES_04535"/>
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    <dbReference type="KEGG" id="fgr:FGSG_04535"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15533"/>
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    <dbReference type="InParanoid" id="I1RKW4"/>
    <dbReference type="OrthoDB" id="5152093at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
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            <end position="134"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF79568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="134" mass="13919" checksum="05FB1504059F18AC" modified="2012-06-13" version="1">MKYLLLLLFTLTTFANATFPVLARRQDSCNGNTKVCGVDCILKSYTCCPSPFYGGCAPGTVCGTDHNGTPGCCPIGKVCLGEVPTGTDNQPAIVTDKVSDNSADSGTANNNAGASDRIDGTAYYFMVGALALLF</sequence>
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            <taxon>Sordariomycetes</taxon>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321048.1">
        <property type="nucleotide sequence ID" value="XM_011322746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RKW8"/>
    <dbReference type="EnsemblFungi" id="CEF79572">
        <property type="protein sequence ID" value="CEF79572"/>
        <property type="gene ID" value="FGRRES_04539"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04539"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15541"/>
    <dbReference type="eggNOG" id="ENOG502SS7G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048145_0_0_1"/>
    <dbReference type="InParanoid" id="I1RKW8"/>
    <dbReference type="OrthoDB" id="4121058at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="74"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF79572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="429" mass="47291" checksum="5AC1616810AF85E6" modified="2012-06-13" version="1">MPKVPAASTWAGAPLVAEDGFAFAEGVFFAQASGQNRHRRATATELKEHFSSSNDKDHPAHWFEAQLIHYGLQPSKTKSTKLKKEWTKNDREAKKGATNSKPAAKPPVAKAETKATAGTKRKATDNDNAPAVKKTKTTTPKATAPARKIANPKAKAKAPPKMPAKVTAKTTTKAPSKAVTESTTPAKPRLKQTARRGGSSQGPGRNASASEPARPPRTKQTARQAGAFAGRGRIPVPPSGNFDAPPPYSEFPDQAYFSDGHSPSNSYRSYDSDPDDGGSLEPLGLLNGDYEITWSDVTEQWDHYDPDNFELCLTLEGNRLWGQFNLGVYEGVLRFNERPMRSSHDRLEFTWRGREDMGPVIYGNSNKGWMEFLGDGRIIGCVDGGQTLSFRAQRIEDQGTRSRTDADSMQDEWSSYTYHLYEQENRARW</sequence>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="22">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="23">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="22">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="21 23" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="21">PH-1</strain>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323380.1">
        <property type="nucleotide sequence ID" value="XM_011325078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RLU2"/>
    <dbReference type="FunCoup" id="I1RLU2">
        <property type="interactions" value="759"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RLU2"/>
    <dbReference type="EnsemblFungi" id="CEF88134">
        <property type="protein sequence ID" value="CEF88134"/>
        <property type="gene ID" value="FGRRES_04911"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04911"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16617"/>
    <dbReference type="eggNOG" id="KOG2608">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023061_1_0_1"/>
    <dbReference type="InParanoid" id="I1RLU2"/>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124342" evidence="20">
        <location>
            <begin position="23"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="90"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="413"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CEF88134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="600" mass="68325" checksum="562F17646AA4DEFD" modified="2012-06-13" version="1">MKSASRLFYLSVFALWAAPGSCESSNDECHISPKSIVGDACASYSTLDKLNLHTKPAIDDLTQNTDFFSHYRVNLFHKKCPFWDDENGMCGNIGCAVETLDNEEDIPEIWRAHALGKLEGPRAKHPGKKAQRQHPQRPLGGLLGENVGESCVFEYDDECDERDYCVPEDESASSKGDYVSLVRNPERFTGYAGDGAKQVWDAVYRENCFQKSSFPKSADLGQSGWQHGPAAQDFKQILDAAGRQAQLEERRQENPNTPFVANTGFEVEDECLEKRVFYRVMSGMHASISTHLCWDFLNQTTGQWSPNLSCYEHRLHKFPDRIGNVYFNYALMTRAIAKLSPYLQKEEYKFCLGDPSEDAATRAKVLEVTEKAASVPQIFDESLMFVNGEGPSLKEDFRNRFRNVSRLMDCVGCDKCRLWGKLQTAGYGTALKILFELDNNNEDVPHLQRTEIVALFNTYARISSSLHNIGEFRKMMEAKVENEKVAKEFDEATEKGRLRAKLEAEAAENDQIDDAMREFIELRAKGPEEESMMGHLEHEFAQFKAVLRIILNGWMRTPKTLWAIFKYETWRLFRLWVGLPVGPRVWTFGLPNVDLGKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1RLW0</accession>
    <accession>A0A098E0B0</accession>
    <name>I1RLW0_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="8">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG04930.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T16663</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323401.1">
        <property type="nucleotide sequence ID" value="XM_011325099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RLW0"/>
    <dbReference type="STRING" id="229533.I1RLW0"/>
    <dbReference type="EnsemblFungi" id="CEF87541">
        <property type="protein sequence ID" value="CEF87541"/>
        <property type="gene ID" value="FGRRES_04930"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04930"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16663"/>
    <dbReference type="eggNOG" id="KOG2431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_0_0_1"/>
    <dbReference type="InParanoid" id="I1RLW0"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF89">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="386"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF87541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="590" mass="66791" checksum="BC9644700DA3BF37" modified="2012-06-13" version="1">MGVALPFTASRALLSLFIAVVVFYCFFHQIPTYRTPKINFIPSSYDWSRHKLQHPVELSSMVKPPRGSPVNLPRIQHDFSNPELRKRELATADVRRKEILQAFKKTWKSYEKHAWGHDELKPLSLQGSDPFGGWAATICDNLDTLWLMGLKREFYKAVDYVSRMDWDLPTSNGFNVFETTIRHLGGLLAAYELSGESALLAKAIEVGDLLYATFDNEEHMPPHTIHFSDLKDGKGRPEPRQSTASLGSMSMEFTRLSQQTGNPKYYDAIDFITKAFERTQNETSIPGLWPIQINAQDGFKVTDNTFGLGANGDSLYEYLIKEYVLLQGLEPKYEKMYLKAADAAIEHLIFRPMLPEKEDVLMLGEATASPRTKEVRLRTDVEHLTCFAGGMYALGGRALGRDDHVTIGEKLARGCAKAYSAYPTGLMPEIVHVERCPTLEPCEFNPSSQKEPLGFRARDTTYLLRPETIESIFYMYRITGKEEFRDIAWDMWLAVRAAAETDEAFAAVMDVNADGEIKHKDSMESFWMAETLKYFYLIFADEELVSLDEHRAGNVSGPGLAAAMGVEGLTRPCPINKQQLKPQRFHFNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I1RMP3</accession>
    <accession>A0A098E3E0</accession>
    <name>I1RMP3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG05237.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T17435</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323748.1">
        <property type="nucleotide sequence ID" value="XM_011325446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RMP3"/>
    <dbReference type="EnsemblFungi" id="CEF88621">
        <property type="protein sequence ID" value="CEF88621"/>
        <property type="gene ID" value="FGRRES_05237"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05237"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17435"/>
    <dbReference type="HOGENOM" id="CLU_1482109_0_0_1"/>
    <dbReference type="InParanoid" id="I1RMP3"/>
    <dbReference type="OrthoDB" id="10412915at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF88621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="182" mass="19970" checksum="D0F39D8C794F4C58" modified="2012-06-13" version="1">MASSQLGENQPVPCSRFTGDFAGRYGDLRALASAPPSCITSDHSNFSSLEVVPVFAPHASDLPPGLDRACHEKEAGRRNSAKGFEMETNSQKRAPEDLFKDMFASVYPLRLFFSTAAHTSHLSNMSQHSQSAISRGRPSDAQRKPYSATLACHSWRYMAHLPGSIKMLFFLKSLATLQDCTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RMQ1</accession>
    <name>I1RMQ1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptide hydrolase</fullName>
            <ecNumber evidence="14">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">FG05245.1</name>
        <name evidence="16" type="ORF">FGRAMPH1_01T17449</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Extracellular aminopeptidase that allows assimilation of proteinaceous substrates.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="14"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323756.1">
        <property type="nucleotide sequence ID" value="XM_011325454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RMQ1"/>
    <dbReference type="FunCoup" id="I1RMQ1">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF87318">
        <property type="protein sequence ID" value="CEF87318"/>
        <property type="gene ID" value="FGRRES_05245"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05245"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17449"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025866_0_0_1"/>
    <dbReference type="InParanoid" id="I1RMQ1"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009997665" description="Peptide hydrolase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="15">
        <location>
            <begin position="166"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CEF87318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="394" mass="43660" checksum="3931392DAC8DBD29" modified="2012-06-13" version="1">MKFSQASLLAACLPAVSARFIEIAEVDNVVLQPDELFLIETAPGKTQWITEEEKWEMRRNGQNFMDITETTTLGSKGINAESTVTFPKKCVKQDEVAKLSKKLEKKNMQANLEKLTSFHTRYFKSDYGLQSSDWVLEKVNQIIKDAGAEDTVFAESFPHTWKQHSVIATIPGQSNSTVVIGAHQDSINLFLPSILAAPGADDDGSGSVTIMEVFRALLNSKDVVKGKAPNTIEFHWYSAEEGGLLGSQAIFKSYEETGRDVKAMLQQDMTGYVQKTLDAGQPESVGVITDFVDSGLTTFIKTVVEEYCDIPWVETKCGYACSDHASASKAGYPSAFVIESAFEYSDPHIHGTDDSIKYLSFDHMLQHARMTLGLVYELGFYGFDGKSEDKWSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1RNP8</accession>
    <name>I1RNP8_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG05632.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T18375</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324195.1">
        <property type="nucleotide sequence ID" value="XM_011325893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RNP8"/>
    <dbReference type="FunCoup" id="I1RNP8">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RNP8"/>
    <dbReference type="EnsemblFungi" id="CEF86092">
        <property type="protein sequence ID" value="CEF86092"/>
        <property type="gene ID" value="FGRRES_05632"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05632"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18375"/>
    <dbReference type="eggNOG" id="KOG3355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070631_2_0_1"/>
    <dbReference type="InParanoid" id="I1RNP8"/>
    <dbReference type="OrthoDB" id="59470at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060904">
        <property type="term" value="P:regulation of protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000002">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF1">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ERV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="7">
        <location>
            <begin position="76"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF86092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="204" mass="22867" checksum="08BE30943EBC15AA" modified="2012-06-13" version="1">MARRQHLTLTFILVLGVFFTLSYFFSGPTRSVLLPKLQNDVELPLKDASRSEFVADLNAMPAGLLQGESIAPKLENATLKAELGHATWKFLHTMMSRFPDKPTKDDRMALETFMHLFARLYPCGQCAEHFRKLLAQYPPQTSSRNAAAGWLCFAHNIVNERVHKPLFDCENIGDFYDCGCGDKDKKGGVEGVAGEGPDQELHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RP91</accession>
    <accession>A0A098DYZ6</accession>
    <name>I1RP91_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG05848.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T18909</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324449.1">
        <property type="nucleotide sequence ID" value="XM_011326147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RP91"/>
    <dbReference type="SMR" id="I1RP91"/>
    <dbReference type="FunCoup" id="I1RP91">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF87085">
        <property type="protein sequence ID" value="CEF87085"/>
        <property type="gene ID" value="FGRRES_05848"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05848"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18909"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012970_2_1_1"/>
    <dbReference type="InParanoid" id="I1RP91"/>
    <dbReference type="OrthoDB" id="4088837at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF92">
        <property type="entry name" value="GLUTATHIONE EXCHANGER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="48"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF87085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="584" mass="63754" checksum="A3C7BB257349BAE3" modified="2012-06-13" version="1">MSLKETNEANHEAKASTPAEAVRDITSPGVQRIKAMSEVITMTDRIFIFLGVFLISYAYGLDGTVRYAYQPSALNEFKEHSLQSSVNTLRAVIAAAAQPTAGKIADVFGRVELICISVFFYTIGTVIEAASQNLDTYSAGAVIYQIGYTMILLLVEVIIGDITSVRSRLFFSYIPALPFIINTWVSGDVTAAVLGATTWRWGIGMWCIIYPVCALPLIVSLLVVGRRAKKQGHLVGYRSSFQQLGLKSFTVELFWLLDIIGVILLIAVFALLLVPLTIAGGFESKWSSPQVVAPLVIGFVCIPVFVVWELRAPHPLVPFHHMKDRSVWAPMGIACMLNFAWTMQGDYLYTVLQVSFNFSIKAATRVQSLYSFASVVTGTILGLIVYKVRRFKVFIVSGTCLFLVAFGLLIRYRGDPSDSNQSGVIGAQILLGIAGGMFPYPAQASLQAYVTHERLAVMTGLYLALYQVGSAMGNAVSGAIWTQVLPARLASSFSGFGNETLAVYTYSQPLSAILDFPVGSVERDAMIDAYKHVQRLLTITGICLCIPLIAFSLCLRNPKLTDQQNLVEDDKPSEATERTTSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1RPY2</accession>
    <name>I1RPY2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T19515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324738.1">
        <property type="nucleotide sequence ID" value="XM_011326436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RPY2"/>
    <dbReference type="STRING" id="229533.I1RPY2"/>
    <dbReference type="KEGG" id="fgr:FGSG_06114"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19515"/>
    <dbReference type="eggNOG" id="ENOG502QPM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013967_0_0_1"/>
    <dbReference type="InParanoid" id="I1RPY2"/>
    <dbReference type="OrthoDB" id="2100241at2759"/>
    <dbReference type="PHI-base" id="PHI:5738"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF2">
        <property type="entry name" value="ALKALINE PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G03860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="2">
        <location>
            <begin position="297"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB64870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="625" mass="70040" checksum="9D81B22E2669DD3B" modified="2012-06-13" version="1">MAVQTKAAKLSSFALRISALVFFRLFPAHFGFAAFTLFAIYVPSYIASYYTKPKVGVLKDEIDVTVKESVTAETPLLTEDGVAVVPEPKIITDVVDVKEKVVIGEKVPGIISILLSGAPSAARPIASFLTFLINALLIGLTADALYRARWYYPSDDLSFVRLGYVSPSEAKFVIREPDQVQMPVIFEYHVKDAESTYDPKMWLTAGFVTSTDNTTDFTTTMTVPLDPAKQMTYEWRTSNNHTGEFRSAPKAGEMPDTKDGLFTFLSTSCILPRFPYSPLDHALAIPGLKNLANLLPTLDAQFMLFLGDFIYVDVPERFGKTAEEYRMQYRQIYASPDWAPVAQNLSWIHVLDDHEISNDWSSNTTGIYSAAVDPWHLYQANVNPPISEAAGPLNLRRNATWYEFTQGPASFFMMDTRSYRSSNNAPFNATDKTMLGKEQLADLLAWLARPVPKGVRWKFIASSVPFTKNWPINVKDTWGGFLTERKQILEAMWDSGARGTSVVILSGDRHEFAATRFPPPVDSQWPQSAAAHEFSTSPLNQFASPFPTYKQTDDEDVMMSYIPGGKSKFGSFSIGKLEDNRSSLYYTLYIDGKETWKATVQAPDSPEDVIQEVVPPSFWDKIKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQF9</accession>
    <name>I1RQF9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG06301.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T19983</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324953.1">
        <property type="nucleotide sequence ID" value="XM_011326651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQF9"/>
    <dbReference type="STRING" id="229533.I1RQF9"/>
    <dbReference type="EnsemblFungi" id="CEF87583">
        <property type="protein sequence ID" value="CEF87583"/>
        <property type="gene ID" value="FGRRES_06301"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06301"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19983"/>
    <dbReference type="eggNOG" id="KOG2218">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015529_1_0_1"/>
    <dbReference type="InParanoid" id="I1RQF9"/>
    <dbReference type="OrthoDB" id="2189254at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060628">
        <property type="term" value="P:regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520:SF0">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1 RINT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51386">
        <property type="entry name" value="RINT1_TIP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF87583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="787" mass="89548" checksum="676D8D6D611C6D62" modified="2012-06-13" version="1">MATTAAHPQGTSLDIRVEDFLDDKLQSTADLENLDTLLENVELQRNQLQSQLDTAVKELEETRRTADDRQASLTARIQEFQKLQESIDLRAQIYAASDAPDQAIERLKSPMNKIKAVERAQSYLVLLQDAEKLRAEAKSFLPQDPKAALEPYIKLKQHVLKLQGLPGQEGLHLVAYVENLTRSLWDDIKSTMSGELEEVLKQRKWPRVEADLQMDEEWINCIEKLIDLQKPEIAHTDKLVTLLPFEIMASIFVSEFRFHFLSDKPTSSPQAFGTHCLSWFIALVEKWEDFFRDNLGYLLAEKFRDTDVATNLAYIDPVSALITSLLPMLKEKTSLVALEAVKSPSFLSSFMSQLMAFDDNVRYKFSYDSGDAENGWSGLTAYVLDDHFDTWFKAEKEFALERYNTIIDSQDARNIDYDYALQGKMKPTYAAVRVTDLLRSVTSQYERVRTFKHKIRFLIGIQLEILDAYHDRLRDSLQAYQSMSTTFGRTLAANKEDLAVLEGTGGFEVLCKVIGSADHVVNTLKDWSNEEFFVSLWDELQTRALHRASQGNNITSTMSYDDVKDRTSAAVGEKREDGALFDETATAYSMRRTAAQELLVGALVESHNKAFRAYTTRVQWTTVGETTISDELAITPELDEPLRILQRNFDFLVKALSTAVFRRVWREALTQLQEHLWQTVLMRQSFTTYGATQFCRDGVALVSIVERYIPNGSSILDSLTEGIQLLSLPVEAGEAGGLTLKEASDRVFTDNEEARKVLEELHLEELSPQSARNILQRRVENNENVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQG1</accession>
    <accession>A0A098E4Y8</accession>
    <name>I1RQG1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG06303.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T19991</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324956.1">
        <property type="nucleotide sequence ID" value="XM_011326654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQG1"/>
    <dbReference type="STRING" id="229533.I1RQG1"/>
    <dbReference type="EnsemblFungi" id="CEF88774">
        <property type="protein sequence ID" value="CEF88774"/>
        <property type="gene ID" value="FGRRES_06303"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06303"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19991"/>
    <dbReference type="eggNOG" id="ENOG502SVX1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039749_2_0_1"/>
    <dbReference type="InParanoid" id="I1RQG1"/>
    <dbReference type="OrthoDB" id="5421765at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF88774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="448" mass="47896" checksum="CDE4655138E0392D" modified="2012-06-13" version="1">MPIHAEPGWSREYTLVNGKTQQFTTTIATSEVIGGTPIELTNVLNAGATVPTITSSNAGGDEQSSLSTNTYITLPSDSSLAVTEIATTSTEDASTGSTPSNELTGTSEVSETGTRGLPSKGLSDGAVAGVAIACIIAGVAIGLVAAFILFRRRLKSTNSSPGFITLESRHVEPKNEPQVNVVASTHDAELEQFLLEATPDKEIQAELRSLSELIYQHVETYYHGPQVLASSAEVAQCIVHIGYSAELSGLQAEAVAAVCLAPRTSRVGMRHVLSHTIFRRLDFNSGGDLSMLPPVIAAMAQEESTPEHADSPAISLARSKWRSLSALLLHPNPAERTPLPLSTDEAPAKAQSLANELNTFLQLFVAQDSARRQDQTNHLQDVILECTRLGYVLLSQPGDWGFVFEAKTTPKERTRRIVVCPGLERLSHNNGTRYGSPKEVAAAETMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>I1RR22</accession>
    <name>I1RR22_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG06527.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T22507</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF82980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326138.1">
        <property type="nucleotide sequence ID" value="XM_011327836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RR22"/>
    <dbReference type="FunCoup" id="I1RR22">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RR22"/>
    <dbReference type="EnsemblFungi" id="CEF82980">
        <property type="protein sequence ID" value="CEF82980"/>
        <property type="gene ID" value="FGRRES_06527"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06527"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22507"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024336_0_1_1"/>
    <dbReference type="InParanoid" id="I1RR22"/>
    <dbReference type="OrthoDB" id="10013407at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02130">
        <property type="entry name" value="PA_ScAPY_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000093">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF17">
        <property type="entry name" value="AMINOPEPTIDASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009997692" description="Peptide hydrolase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="10">
        <location>
            <begin position="151"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="11">
        <location>
            <begin position="262"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF82980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF82980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="510" mass="55087" checksum="7A05DF0E66C0C785" modified="2012-06-13" version="1">MTTKSFCLVAATAALSGVSALQIPLNLQVPKLSWSPFSDDLPLVDTKELQKSIKPENLEARAKDLYEIAKNGEEEYGHPTRVIGSEGHLGTLSYIHAELAKLGGYYTVSNQQFPAVSGNVFESRLVLGNDVPKEAAPMGLTPPTKNKEPVYGKLVLVDNEGCNESDYPEAVKGNIALVLRGTCPFGTKSGNAGKAGAVAAVVYNYEKGDVHGTLGTPSPDHIATFGLGGDEGKAVVKKIKDGEEVDAIAYIDAEVKTISTTNIIAQTRGGDPDNCVMLGGHSDSVAEGPGINDDGSGSISVLEVAVQLTKYRVNNCVRFAWWAAEEEGLLGSDHYVSVLSDEENQKIRLFMDYDMMASPNFAYQIYNATNAANPKGSEELRNLYVDWYEEQGLNYTFIPFDGRSDYDGFIRGGIPAGGIATGAEGVKTEEEVAMFGGEAGVWYDKNYHQIGDDLTNVNYTAWEVNTKLIAHSVATYAKSFKGFPERSSEAVVQSETYSDKTKYHGSKLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1RRD1</accession>
    <name>I1RRD1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG06650.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T22831</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326277.1">
        <property type="nucleotide sequence ID" value="XM_011327975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RRD1"/>
    <dbReference type="EnsemblFungi" id="CEF83701">
        <property type="protein sequence ID" value="CEF83701"/>
        <property type="gene ID" value="FGRRES_06650"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06650"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22831"/>
    <dbReference type="HOGENOM" id="CLU_1825390_0_0_1"/>
    <dbReference type="InParanoid" id="I1RRD1"/>
    <dbReference type="OrthoDB" id="10272269at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124456" evidence="1">
        <location>
            <begin position="22"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF83701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="141" mass="15380" checksum="8D83B3C6D709AE96" modified="2012-06-13" version="1">MLLGSCSFAFLFTLLFQLEIAVNYAKLDGVVLAFAVASRHLHQWHYNPTLERGLAYLLGVKVTCVDKGVHKDDQRAVALWPTKFGSASTVGPRLVVMIMGLDGSRDHERSGKALKGLSQVKHGRPPNQRASVTMACIASCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I1RRZ0</accession>
    <name>I1RRZ0_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome maturation protein SDO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG06894.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T23441</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326559.1">
        <property type="nucleotide sequence ID" value="XM_011328257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RRZ0"/>
    <dbReference type="FunCoup" id="I1RRZ0">
        <property type="interactions" value="1040"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RRZ0"/>
    <dbReference type="EnsemblFungi" id="CEF84937">
        <property type="protein sequence ID" value="CEF84937"/>
        <property type="gene ID" value="FGRRES_06894"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06894"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23441"/>
    <dbReference type="eggNOG" id="KOG2917">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043216_1_0_1"/>
    <dbReference type="InParanoid" id="I1RRZ0"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990932">
        <property type="term" value="F:5.8S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1250.10:FF:000001">
        <property type="entry name" value="SBDS, ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="10">
        <location>
            <begin position="16"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="11">
        <location>
            <begin position="112"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="12">
        <location>
            <begin position="242"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="146"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF84937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="308" mass="33682" checksum="3AC8214618380734" modified="2012-06-13" version="1">MSRQIQQPSNQIKLTNVSLVRLKKGKKRFELACYKNKVLEWRSGIETDLDNVLQIPNVFLNVSKGQTAPREDLDKAFGKGKSTDDIILEILKKGEMQVGEKERAAQTERVHNEVVSIVASKLVDPRTKRVYTSGMIEKALDMLSSQAHNATPDKSAAGSATGTPATGEAGEAKPRPQHNWTGVSTTKSAKSQALEAMKALIAHQPIPVARARMRLRIACTTNVLKQAIKAPKGANKEEEGEQKAVGTVKDKILSYVEQVESQDVVGSEWEVVGFVEPGAFKPLSDFIGNETKGQGRVEVLDMAVTHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I1RSG2</accession>
    <name>I1RSG2_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T23913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326781.1">
        <property type="nucleotide sequence ID" value="XM_011328479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RSG2"/>
    <dbReference type="STRING" id="229533.I1RSG2"/>
    <dbReference type="ESTHER" id="gibze-i1rsg2">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07080"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23913"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_7_1"/>
    <dbReference type="InParanoid" id="I1RSG2"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="129"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="69"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SCB65185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="636" mass="70569" checksum="3C9487FB049713B6" modified="2012-06-13" version="1">MTAAPKRQDPISEEDSVHIPNETTAPTKKPSRKKWFIIGGIVILVVLVLSLTLGLYYGLKKKEHDVVNDSAAKSNADPPQPSNVPDKDSNDSDDNNNDNDNNNDKGNDNGNSKGESSDESTKKKEGPFVDLGYSQYEGNVLSSDIYEYLGIRYAKSTSSDMRWKAPVAPDSTTEVLKAQKYAPFCPGVNDRLGSTIDEDCLFVNVWAPANVTSDSKLPVMVFFQSGGYIRNASPYINGSGLVTASNNSIIYVNFNYRVGMFGFLAGKEIKEDGDLNAGLLDQRFLLKWVQEHIQEFGGDSERVILHGQSAGAGSVALQLAAYGGKDEGLFAGAIAESVFMPGLPEPNDIQYQFDRVVNATNCSEEDDTLACLRGMDSSALQAQNIKAPFDGRDYRSYFYWAPTTDGDMFPDFPSELYKKGNFAKVPLLTGSCTNEGSNYAVNAGSSAQFIRYMQNEYPYLTTKDTETILELYPKEPALPKHDIWFPSASRAYAEVTFVCPTNNMLDAYAEHADPETLWSYRYNVQITEFIEDGLGVPHVANAPAVFGPDYTAAKAGPSYRTYNAPMIPVVQSYWISFVHNLDPNKDRYEGTPKWENWGDDQRRLVFELNNNTMETVDQGQKDRCQAWLDMSDSTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1RTL8</accession>
    <accession>A0A098DP72</accession>
    <name>I1RTL8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG07529.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T25025</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327305.1">
        <property type="nucleotide sequence ID" value="XM_011329003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RTL8"/>
    <dbReference type="EnsemblFungi" id="CEF83169">
        <property type="protein sequence ID" value="CEF83169"/>
        <property type="gene ID" value="FGRRES_07529"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07529"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25025"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_1_2_1"/>
    <dbReference type="InParanoid" id="I1RTL8"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="235"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF83169"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="570" mass="62574" checksum="47B6FD2B141ED14E" modified="2012-06-13" version="1">MSKEDDQTQESHPHHHPLTREPTREEKTREAIAEGHDADIPSNIGFIPTEADEQRRRSSVARSRRASHASKRAASPDPNKESGDVRDEEEGASQTQSESDIVWWDGDKDRQNPYNFATWKKVLNCFLVSALTFVTPLASSMFAPGVPQLMVEFGSRSPELASFCVSVYVLGFAAGPMIFAPLSEIYGRQIVYHCCNVGFIVFIIASAKAPTLSSFIAFRFLSGTFGSAPITNGGGTIADMIVQEKRGAAMAIFSIGPLLGPIIGPVVGGVVTDALGWRWVFWIIAIISGVLSTVFFFASEETYAPVILARKTKRLQKETGNDRLRSKLDAGLSPADYFKRGILRPFKMLAFSPICIICGVYVGLAYAYLYLLFTSLTPLFMRIYHFNTVNAGLTFLGLGVGSLIGVGYFSVSSDKYMKKKAALAKEQGIVELSEIMKPEYRLPPLRFGAILLPVGFFIYGWTAEYETHWIAPILGTCVIGVGNLVIFMSLQMYLIDTFTIYAASALAANAVMRSIAGAVLPLAGLPMYNKLGMGWGNSLLGFIAAALIPAPWLFIKYGEHLRKKFEIKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RUS7</accession>
    <accession>A0A098DE35</accession>
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        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320859.1">
        <property type="nucleotide sequence ID" value="XM_011322557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RUS7"/>
    <dbReference type="EnsemblFungi" id="CEF76211">
        <property type="protein sequence ID" value="CEF76211"/>
        <property type="gene ID" value="FGRRES_07981"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07981"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08817"/>
    <dbReference type="eggNOG" id="ENOG502SP8C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053555_0_0_1"/>
    <dbReference type="InParanoid" id="I1RUS7"/>
    <dbReference type="OrthoDB" id="3538998at2759"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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        <location>
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        <location>
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            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF76211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="306" mass="33796" checksum="61B4B34E19D24261" modified="2012-06-13" version="1">MPRYLTILRLVSLLTITNPISATKYGYIESKECVDPSGYELCYKSRDDERNVCINKNCEGQNIDCLNACDCVFNVDVIDCALTHCWNKVYSCEYQNTVLELGGPCIDEKFKDIPFFPAPDDVPDACSCNLGKIATSLNRAVDELDTCIERNQEIWDSLSIDEQGNLLISQDEDYPQCGDYNDAYNCANDLKFTPPGKDNSAKFYAPGEFPKNGTKTMSNMDGSITSPLSGATFTWTNGNIVHPITGASVDAKPTDNSKNNENKTDDTEEIGKEDEEETGEEDEEGAGSAITPHLWVLVCLVLVLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I1RV87</accession>
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        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
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        <name evidence="2" type="primary">FG08152.1</name>
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    <organism evidence="1 3">
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        <lineage>
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            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320661.1">
        <property type="nucleotide sequence ID" value="XM_011322359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RV87"/>
    <dbReference type="STRING" id="229533.I1RV87"/>
    <dbReference type="EnsemblFungi" id="CEF76422">
        <property type="protein sequence ID" value="CEF76422"/>
        <property type="gene ID" value="FGRRES_08152"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08152"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09239"/>
    <dbReference type="HOGENOM" id="CLU_1865296_0_0_1"/>
    <dbReference type="InParanoid" id="I1RV87"/>
    <dbReference type="OrthoDB" id="2520703at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF76422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="137" mass="15216" checksum="68D0C067176CD660" modified="2012-06-13" version="1">MAAKNVAPAAFNDQDSSTYWSSVGTSLLLSICSNITRLVLVDGVAHGLCKYSPSLWGTFKCDRLKYLEYRFIDMHEWTPEVLSLLVNASPIVDVLALRGMLNWRCTNSDSADIAKLLPALNNPTEIRVLNRSEPTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1RWB3</accession>
    <name>I1RWB3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG08576.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T10299</name>
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    <organism evidence="6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320174.1">
        <property type="nucleotide sequence ID" value="XM_011321872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RWB3"/>
    <dbReference type="STRING" id="229533.I1RWB3"/>
    <dbReference type="EnsemblFungi" id="CEF76953">
        <property type="protein sequence ID" value="CEF76953"/>
        <property type="gene ID" value="FGRRES_08576"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08576"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10299"/>
    <dbReference type="eggNOG" id="KOG1213">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025342_0_0_1"/>
    <dbReference type="InParanoid" id="I1RWB3"/>
    <dbReference type="OrthoDB" id="5427633at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21789">
        <property type="entry name" value="Rad21_Rec8_M_SpRec8p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF70">
        <property type="entry name" value="RAD21_REC8 N TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G02900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="285"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="413"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="487"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF76953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="687" mass="75333" checksum="3E1C3E1376968125" modified="2012-06-13" version="1">MFYSHEILSNTRYGVATIWLVATVGNSSQKRLTRKAIQGVDVPKACETIIDPGAPLALRLQGNLLYGVSRVYSQQCHYVLSDAEKTQSNMMTFFRAMNTNETDPNAGKSKRHQITLQDDPSFDPLSAVPKLDLLASVDDLVFLSTQLSTQNNVSQMTPLTQGTSSSGRGNSLLNFGIPQSSQSGRSYRLPTDLDLDLPNPFHAQDPFEEFNPFGEDIANIPDLDLNFDIDGNLVDFGNPEPELPPLPGTTAYEEQLHIQAANTANLDTNKGHDAGDNVIIMGEDPLPDAEPFPKRPTTTKLTSNAEPTTTSTTETLKVKAPLRRGRPRRKHQMIDKKDYVPSATIRGWHWAYSDNMKAVLKLRPVTTTAQARRNAKTFLFDNGLAGVAKSPLGKTHPLAGKFSGMALLAQLQGRDPEPEPELQSRGRRRTSAEAFPDEQDEQRNIRQRTENENDGDEFGRGHAKDTGAIMFGEDLAPEIGLDAAKGLEDRHSSSMAPWSRPPSIAPGSSLRGHGSVQKRHLAPSPLHGRGSVVRSIERFSDLPDLPDNSDDVAMLHSQDSSMGNEGLMGDFDFTDGKDTQNSGVIDSSALDFLGYATARAQERGYTRPRDQADRRWIDFNTLTEELDDPTSTKKFVSEAFMHVLVLATKSIVAVEQEGIADNQPFGTIRIGLTAPGKDVDDTADELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1RWI5</accession>
    <name>I1RWI5_GIBZE</name>
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        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 1A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG08655.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T10493</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320087.1">
        <property type="nucleotide sequence ID" value="XM_011321785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RWI5"/>
    <dbReference type="FunCoup" id="I1RWI5">
        <property type="interactions" value="800"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RWI5"/>
    <dbReference type="EnsemblFungi" id="CEF77049">
        <property type="protein sequence ID" value="CEF77049"/>
        <property type="gene ID" value="FGRRES_08655"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08655"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10493"/>
    <dbReference type="eggNOG" id="KOG3403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109098_0_0_1"/>
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    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="PHI-base" id="PHI:1590"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000071">
        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="10">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="115"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF77049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="157" mass="17659" checksum="5DCA2133C7397A49" modified="2012-06-13" version="1">MPKNKGKGGKNRRRGTKENDDQRRELTFKEDGQEYAQVIKMLGNGRLEALCFDGSKRLANIRGKMRKKVWINQGDIILLSLRDFQDNKGDVILKYTADEARTLKSYGELPENAKINETDSFGQGEDGEAYFEFGDADSDEDSDDGAAGKKEVDIDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I1RWL3</accession>
    <name>I1RWL3_GIBZE</name>
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        <submittedName>
            <fullName evidence="14">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FGRAMPH1_01T10573</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320050.1">
        <property type="nucleotide sequence ID" value="XM_011321748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RWL3"/>
    <dbReference type="STRING" id="229533.I1RWL3"/>
    <dbReference type="KEGG" id="fgr:FGSG_08688"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10573"/>
    <dbReference type="eggNOG" id="KOG0238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_3_1_1"/>
    <dbReference type="InParanoid" id="I1RWL3"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="13">
        <location>
            <begin position="44"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="12">
        <location>
            <begin position="160"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="11">
        <location>
            <begin position="650"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SCB65647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="734" mass="80632" checksum="EBA3FC5E8A2DECA5" modified="2012-06-13" version="1">MRSTLRANRRLPLKSLPRFLSTTAPSSASTPSVASSSPTPKQTPISSVLIANRGEIAIRINRTAERLGIRATTVYTDIDAGSWHASSGFQSLGLGPANAYLDGEKIISLAKQNGIQALHPGYGFLSENSKFAERCEEEGIVFVGPPATAMADMGHKARSKEIMTAANVPCVPGYHGADQGEQELLEHAKKITFPVLLKSVRGGGGKGMRIVLTEEEFLTQLRSARAEAKASFGEGGEVMLVEKYIIRPRHVEVQVFADKWGNTVALGERDCSIQRRHQKILEESPAPDLDLATRHDLWDKARKAASAVGYVGAGTVEFILDKDTNKFYFMEMNTRLQVEHPVTEMVTGLDLVEWQFRVAAGEKLPLSQEEVETQMNERGAAIEARIYAENPEKGFIPDSGKLVRAYLPAELQNEDVRLDWGFRSGNTISEAYDGMIAKLIVRGDTRERAIAKMESVLRSYEIVGVATNIEFLKRLCETDAFVEGDVETGFIDKWREQLFKPRPIKNEVVAQAALGMVNSELQNSGPHGLTLGFGEANSIGERKLSFKIQDGYSQEEGEVVEASVTQVAHNLYNVSISRKGNETPQVFTNIACKPEPEGEVMKLESYFPFERIQSSVVPQHTDNDTKVTVFQHGVKTDLVLLPPKWYEKALGLKESSASVAAPMPCKILKNEVEEGQTVQKGAPLVVIESMKMETIIRSPQDGVIKKLAHKAGDICKAGTVLVMFEEAEGKDGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1RWQ1</accession>
    <name>I1RWQ1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T10679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320001.1">
        <property type="nucleotide sequence ID" value="XM_011321699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RWQ1"/>
    <dbReference type="FunCoup" id="I1RWQ1">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RWQ1"/>
    <dbReference type="KEGG" id="fgr:FGSG_08730"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10679"/>
    <dbReference type="eggNOG" id="KOG0566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025224_1_1_1"/>
    <dbReference type="InParanoid" id="I1RWQ1"/>
    <dbReference type="OrthoDB" id="62798at2759"/>
    <dbReference type="PHI-base" id="PHI:5756"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF286">
        <property type="entry name" value="5-PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB65653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="483" mass="54204" checksum="76689EC9F5C3E965" modified="2012-06-13" version="1">MTSPTVPSVDLLYLTFNCAKSLLDIPVFSAHLQTAFHQNATDLPQVVVLSLQEVAPLAYSFIGGYFLNSYISRYEQAINIAAQHVLDNITSRESDTITITPTTRPAKPYTLVRGNNVGYTAILLFARDPSKLKDIQEAEVGFGAAEMGNKGAVGLRMLYEGDDGSSELTFVATHLAAMEWNLPRRNANWAAIMRGMAFGNPEVVVNSYKTSITPSPASTPPAEDQPEHVRLLDDELNEQHSRFQQELHNISVFKPTSHLFVAGDLNYRISTTSPPPSAAFPSLDPESENYYPDFFRLDQLTRERNAGRTLHGLSEHEVRFPPTYKYDVLPQRPGTQELELDVPWKFAAHRYPGWTDRVLFLEVPSWLKKGDDKDPRINVRAYDCLPVLRMSDHRPVFLRADVPLIAPGEMAPPSSVDPDVSKDPRARLPVEIDPEAWERRAAARRKEVMAGWSMYLWSTKEGACILATILAFGAGVYWLYHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RX04</accession>
    <accession>A0A098DFR4</accession>
    <name>I1RX04_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">FG08845.1</name>
        <name evidence="14" type="ORF">FGRAMPH1_01T10979</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The VLRF1 domain mediates binding to the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ANKZF1/VMS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319867.1">
        <property type="nucleotide sequence ID" value="XM_011321565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RX04"/>
    <dbReference type="FunCoup" id="I1RX04">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RX04"/>
    <dbReference type="EnsemblFungi" id="CEF77292">
        <property type="protein sequence ID" value="CEF77292"/>
        <property type="gene ID" value="FGRRES_08845"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08845"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10979"/>
    <dbReference type="eggNOG" id="KOG2505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014293_1_1_1"/>
    <dbReference type="InParanoid" id="I1RX04"/>
    <dbReference type="OrthoDB" id="429841at2759"/>
    <dbReference type="PHI-base" id="PHI:1406"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047139">
        <property type="entry name" value="ANKZ1/VMS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041175">
        <property type="entry name" value="VLRF1/Vms1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036">
        <property type="entry name" value="ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036:SF2">
        <property type="entry name" value="TRNA ENDONUCLEASE ANKZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18826">
        <property type="entry name" value="bVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52044">
        <property type="entry name" value="VLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VLRF1" evidence="13">
        <location>
            <begin position="226"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="462"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="109"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="531"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="539"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="608"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CEF77292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="632" mass="70502" checksum="F4CA4BDC03238B38" modified="2012-06-13" version="1">MAKTNEDLLRRPLYLYDLPVNVLDTLVLKDDADAEDIAAAESAASSLTESSSDSNLVGTQACSLCGLTFTTVIDQRGHLKSDLHHYNLKQKLRGQKPVSEAEFEKLVGNLDESLSGSDSEESDEEEDGRQESTLTTLLKKQARLTENAGDDDEGETAGRAGRGKPPLIWFSSPLLPEKNYFGMYRAILTGDEQRNQDLVEVLKKKQVEPIAMPKIKEGALPEVAYKGPHIFLCMIGGGHFAAMVVSLAPRPNKNGTTMNREATVLAHKTFHRYTTRRKQGGSQSANDNAKGAAHSAGSSLRRYNEQALVEDVRNLLQEWKALIDTSELLFIRATGMTNRRTLFGPYEGQVLKHNDTRLRGFPFSTRRATQNELMRSFIELTRLKVREIVPVEETKKEADVVPKTSTKPSKPKLSEEEETALLHTSQLQAFVRRSKVPALLSYLKNNSITADFEFQPVEQNHHAPRPLHLAAAQNAAPLVLGLLVRGGADPTIKNNEGKTPFELAGERSTRDAFRVARSELGEAKWAWDDAKVPPAMTKAEADKRDEREKKEACDKEAERRKAEEERLQSEGPKVPEGRKQKGNILAAGLKQTPQEKREAEARGLTPEMRMRLERERRARAAEERLRKMQSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1RYA8</accession>
    <name>I1RYA8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG09350.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T27293</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328396.1">
        <property type="nucleotide sequence ID" value="XM_011330094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RYA8"/>
    <dbReference type="STRING" id="229533.I1RYA8"/>
    <dbReference type="EnsemblFungi" id="CEF85730">
        <property type="protein sequence ID" value="CEF85730"/>
        <property type="gene ID" value="FGRRES_09350"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09350"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27293"/>
    <dbReference type="eggNOG" id="ENOG502QTW7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_7_2_1"/>
    <dbReference type="InParanoid" id="I1RYA8"/>
    <dbReference type="OrthoDB" id="3548654at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="215"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF85730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="763" mass="85377" checksum="EB116455B8694897" modified="2012-06-13" version="1">MTEREPTTKKSQARLSSLFRRKTVIEDRHEPTPLSSPVQAPVSHYPAYIAEYQLKSQSQSPVSPLRHSQSSNTGRGNYRPYPKPALAPFPIPGSLVSKIEEREAMAATNMQNPTMAQSPQSPVSNPEETYRVSLLSGRDVTDFPPTSSNTYDITPISSAISRPSVVSTLDYSDQQPYEYTPLETGFIRLVRIAPGHKTMIECEIIQALITNVPQYVAVSYTWGDVGDTKKIDIEGSCVPITVSLYGALEALRQRQSSVLVWVDALCIDQKSTEERNQHVQLVSQIYANAAFVAIWLGPEDNDSTKAVELLSRLAPPNSQFIPDQDVSRILAEGAENGDLLATVSLFGREYWKRLWVSQEIFHAKRVAVHCGETFLPWQSYKSASTCFRRNHAELVFRTKGPDMRRPDKFTCVQTLIHGGPASLPALSHHVLNGQNALLQVLRASRSQVSSDPRDKLYGILSVLPAHIRQGFRVDYTLSVKDVYTEIVEFLIQSTEKLDVICESVHFPVNTGPAKLPSFVPDWSHVPLTLAMGHQYGFQASGHTKAICRFHDERLNKLEVSGIEIDVVQTKGMVVGTLCNLGDFLMAFLHWRALLLAAVEGRTPFQVKLAEEAFVATICLGQITTGYDRSRWQQVSYHVIANLFRERLLHIPLDDILRSHLDIASSIPPEARRQFLQTNFGDRMMGRTFCLTQNRRLGVGSGAMLPGDVVVVPLGCSTPVLLRPEGTQGEYRFIGDIYIENYMFGKAVDQWQVGERELKKYVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZP7</accession>
    <name>I1RZP7_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG09898.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T06789</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318804.1">
        <property type="nucleotide sequence ID" value="XM_011320502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZP7"/>
    <dbReference type="STRING" id="229533.I1RZP7"/>
    <dbReference type="EnsemblFungi" id="CEF75199">
        <property type="protein sequence ID" value="CEF75199"/>
        <property type="gene ID" value="FGRRES_09898"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09898"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06789"/>
    <dbReference type="eggNOG" id="ENOG502S8MB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080764_1_0_1"/>
    <dbReference type="InParanoid" id="I1RZP7"/>
    <dbReference type="OrthoDB" id="5397701at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331:SF1">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF75199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="231" mass="24538" checksum="18A0ADA62591D7F4" modified="2012-06-13" version="1">MLGAKYLFVARQRAVSSRAISSLSSNPSIKVVKSPKAPFTNYLSYLDKEPPNEHLVIGTTTQLPPTPQSFSENREFVKILDEVVSEYGHQDEDLINQARAFASPGGFNLGSGGVFFPQKRPDRSGSRKQGARGAAGGDGAGGASAQGGAGGGGRGGYVHLSDRRNPPDFGRIAWPEDILGSVEVDDAGTIIGKVQPSGTYRILTNEGILGLSPFLQGKLVERLKQEAAKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1S0L4</accession>
    <name>I1S0L4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG10246.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T07635</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319196.1">
        <property type="nucleotide sequence ID" value="XM_011320894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S0L4"/>
    <dbReference type="FunCoup" id="I1S0L4">
        <property type="interactions" value="995"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1S0L4"/>
    <dbReference type="EnsemblFungi" id="CEF75621">
        <property type="protein sequence ID" value="CEF75621"/>
        <property type="gene ID" value="FGRRES_10246"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10246"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07635"/>
    <dbReference type="eggNOG" id="KOG0857">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084051_0_0_1"/>
    <dbReference type="InParanoid" id="I1S0L4"/>
    <dbReference type="OrthoDB" id="10258869at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.300:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF75621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="221" mass="25348" checksum="9A20BD4D0A67841B" modified="2012-06-13" version="1">MARRPARCYRYCKNKPYPKSRFNRGVPDPKIRIFDLGRKRANVDDFPLCIHLVSNEYEQLSSEALEAARICANKYLVKNTGKEGFHLRVRAHPFHVVRINKMLSCAGADRLQTGMRGAWGKPNGTVARVNIGQILMSVRTRDANRAIALEALRRSQYKFPGRQKIIVSKNWGFTPLRREEYLDKKAAGRVKVDGAYVQFLSNHGSLERNIRRFPDAFKSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1S1U5</accession>
    <accession>A0A098DB93</accession>
    <name>I1S1U5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG10715.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T08771</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF76188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319731.1">
        <property type="nucleotide sequence ID" value="XM_011321429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S1U5"/>
    <dbReference type="STRING" id="229533.I1S1U5"/>
    <dbReference type="EnsemblFungi" id="CEF76188">
        <property type="protein sequence ID" value="CEF76188"/>
        <property type="gene ID" value="FGRRES_10715"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10715"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08771"/>
    <dbReference type="eggNOG" id="ENOG502S50Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1256120_0_0_1"/>
    <dbReference type="InParanoid" id="I1S1U5"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
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        <property type="entry name" value="DOMON DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
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            <end position="220"/>
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            <end position="76"/>
        </location>
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        </location>
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            <end position="172"/>
        </location>
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            <end position="47"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00665"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF76188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="220" mass="23761" checksum="80CA8A24BE92089A" modified="2012-06-13" version="1">MKYISRTPIASALALAILVWPVLSSTQPSSGLSDGATAERGNGDNKTGTTGTIHGVIMSIVFLLGFPIGSFLMPLIRKWLIHASWQIIVFIGMCAGFGVGKIAADRSGDWISDPHVVLGTFVCILMVVQPILGWIHHRNYVKYERRTKVSYGHIWFGRALMFIGIINGGTGLQLSGASSGPIIAYSVIGAIVFSIYTGGVVLKEVRLRGREVDDQSVMEL</sequence>
</entry>
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    <accession>I1S2K0</accession>
    <accession>A0A098E0B4</accession>
    <name>I1S2K0_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG10996.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T20971</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325374.1">
        <property type="nucleotide sequence ID" value="XM_011327072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S2K0"/>
    <dbReference type="STRING" id="229533.I1S2K0"/>
    <dbReference type="EnsemblFungi" id="CEF87546">
        <property type="protein sequence ID" value="CEF87546"/>
        <property type="gene ID" value="FGRRES_10996"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10996"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20971"/>
    <dbReference type="eggNOG" id="ENOG502S44G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020416_1_0_1"/>
    <dbReference type="InParanoid" id="I1S2K0"/>
    <dbReference type="OrthoDB" id="3437405at2759"/>
    <dbReference type="PHI-base" id="PHI:9044"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
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            <begin position="31"/>
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        </location>
    </feature>
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        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF87546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="648" mass="75399" checksum="E5FC615F2273C34C" modified="2012-06-13" version="1">MSSRAERLLRLEMALTASGRRNYTDTDEDGERSGNVRHSDNPTDISHLVPPQSGGKHRLWITDRILEPQTIPHFIEFLMHGCLPGDRKTSRPLLTVEEARNMDKPFPEWAPAPFNVEQRSTTEWIGVRIGSHEDSSRLWLIAKELHAMKSRLWEGIPPLSERRWNELQLDDPKNFAAACQYFVAVIDVFAYLNHPRTKNALRTTYNLIWDHLRVFEQAVNAKRRDENEVYEEVSVTGLWYQYIRAHYDCICDSAHQWVIEHINRIQEPLVLEIGNHKSTNPSDVDARQKEITDKIDDLGQNTMDADYMIFMPTDGYKGDSLPAKERAQVTAAHRHPFRKDPITWSANINWRERDYSGRLRYLQTKEMYNHYEREGLLFEPTINDPRVLLIGCISGIDAQTTARYEMRGPSEPTMDRWIEYAQRPVFRVNGFAAFRLCHKHDDKKWNEFKTKFEVDIADWGLGKKDINDVRKGCKIHWIDGKVDSIKDAKMKFNSVVSDLPVHHRMFLAIDEATIQSYLKPNASKFVLAIDAQYRSVEEREEENEPPNEQEHETPGYDGTMRILGSLLWDELGAMQTTQGVLLKHLWPYAMSDVEKVYRGYKPGIVLKFSSYEETMAWEVLNALLPFVLKLAERRDRSRRTNPRTSAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1S3C2</accession>
    <accession>A0A098DWT6</accession>
    <name>I1S3C2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 3, complete genome</fullName>
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    <gene>
        <name evidence="7" type="primary">FG11299.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T21727</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF85812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325945.1">
        <property type="nucleotide sequence ID" value="XM_011327643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S3C2"/>
    <dbReference type="SMR" id="I1S3C2"/>
    <dbReference type="ESTHER" id="gibze-q4huq9">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF85812">
        <property type="protein sequence ID" value="CEF85812"/>
        <property type="gene ID" value="FGRRES_11299"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11299"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21727"/>
    <dbReference type="eggNOG" id="ENOG502S05E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019364_0_0_1"/>
    <dbReference type="InParanoid" id="I1S3C2"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="131"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF85812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="386" mass="43043" checksum="0C61D05E21F31B60" modified="2012-06-13" version="1">MALMDSVKLCFGYVHAALITPWLLSHFLFDITLCLIPYLRPSRKWSLNQAVRVRLIRLVLLYWSLTKYGDRLRLDPKREKNRFEVVSPRSPKLYRGILSDYVVRPAQLGMTWTPARPPPAGLVNSNMVVALHFHGGGYVIGNGRDEDTGFLAKTLVRRMGCSHVCTPQYRLSSSNNGQFPAPLQDALTAYLDLIKSKGIPASQIILSGDSAGANLALALVRYIHEHGKDDHIPFPRAMALWSPWVDIAGALEQDVKQSPNYKTDYLNMYFARWGAATVSGYGITDPAGPYLSPLRNPFKLEESLPVYVNAGGGEVLCEDIKNFCQRYEKYGWNIHLDVSEGCPHDILLLGDTMGFGAEAKKAAENARGFLNVNAGLRLQSYSPREL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-06-17" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1S3K6</accession>
    <name>CHRY6_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamine amidotransferase-like protein chry6</fullName>
            <ecNumber evidence="5">3.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Chrysogine biosynthesis cluster protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">chry6</name>
        <name type="ORF">FG11394</name>
        <name type="ORF">FGRAMPH1_01T21957</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2017" name="J. Nat. Prod." volume="80" first="2131" last="2135">
            <title>Chrysogine biosynthesis is mediated by a two-module nonribosomal peptide synthetase.</title>
            <authorList>
                <person name="Wollenberg R.D."/>
                <person name="Saei W."/>
                <person name="Westphal K.R."/>
                <person name="Klitgaard C.S."/>
                <person name="Nielsen K.L."/>
                <person name="Lysoee E."/>
                <person name="Gardiner D.M."/>
                <person name="Wimmer R."/>
                <person name="Sondergaard T.E."/>
                <person name="Soerensen J.L."/>
            </authorList>
            <dbReference type="PubMed" id="28708398"/>
            <dbReference type="DOI" id="10.1021/acs.jnatprod.6b00822"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="2 5">Glutamine amidotransferase-like protein; part of the gene cluster that mediates the biosynthesis of the yellow pigment chrysogine (PubMed:28708398). Pyruvic acid and anthranilic acid are likely substrates for the nonribosomal peptide synthetase chry1/NRPS14, with pyruvic acid adenylated by the first A domain and anthranilic acid by the second (Probable). If pyruvic acid and anthranilic acid are merged and released from chry1/NRPS14 by hydrolysis, a subsequent amidation would lead to 2-pyruvoylaminobenzamide (Probable). This process is probably catalyzed by the amidotransferase chry2 using glutamine as amino donor (Probable). The dehydrogenase chry5 that has a terminal berberine bridge domain for C-N cyclization could catalyze the cyclization of 2-pyruvoylaminobenzamide to yield acetyl-4(3H)-quinazolidinone (Probable). A final reduction of acetyl-4(3H)-quinazolidinone catalyzed by the oxidoreductase chry4 would result in chrysogine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pigment biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C26 family.</text>
    </comment>
    <dbReference type="EC" id="3.-.-.-" evidence="5"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325839.1">
        <property type="nucleotide sequence ID" value="XM_011327537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S3K6"/>
    <dbReference type="SMR" id="I1S3K6"/>
    <dbReference type="STRING" id="229533.I1S3K6"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T21957">
        <property type="protein sequence ID" value="FGRAMPH1_01T21957-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G21957"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11394"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21957"/>
    <dbReference type="eggNOG" id="KOG3179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054974_0_0_1"/>
    <dbReference type="InParanoid" id="I1S3K6"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000450176" description="Glutamine amidotransferase-like protein chry6">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-1" evidence="1">
        <location>
            <begin position="13"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="28708398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="28708398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="28708398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF87652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="240" mass="25874" checksum="CAC782F0ED892B1A" modified="2012-06-13" version="1">MSSPSFRVAILANFILDDTGGRPMIDKITQLIRQSKPDAEINVYAAIEGDTLPDPETKDLIILTGGPFNLLKDERPKWVVDTLEYLKTVTAGPSKPKILGICWGQQAIALALGGALGKSDKGQIVGIADIPLTPEGTKFFESPSLTIHKNHEILVTDIGPHLLPLALNNEVLMSKDGQVLTFQGHPEMDSVLSRLFVASDNPVLVGAGSDSGLKPIDSPHDGEIIFERIVRWASPETAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I1S553</accession>
    <accession>A0A098D486</accession>
    <name>I1S553_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T03875</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317404.1">
        <property type="nucleotide sequence ID" value="XM_011319102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S553"/>
    <dbReference type="EnsemblFungi" id="CEF73743">
        <property type="protein sequence ID" value="CEF73743"/>
        <property type="gene ID" value="FGRRES_11971"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11971"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03875"/>
    <dbReference type="HOGENOM" id="CLU_2413439_0_0_1"/>
    <dbReference type="InParanoid" id="I1S553"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF73743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="92" mass="10421" checksum="E7AD14766C27C8AC" modified="2012-06-13" version="1">MSSCILFHNVSHSPSAMYVIRSYMRRLISETAAPKNIYGVIRRQANGHDCQLSPIFNAPGRWKFEAINGNTLVLVIVKNNKPVTKKAIDKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I1S5K7</accession>
    <accession>A0A098D8A6</accession>
    <name>I1S5K7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T05761</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318316.1">
        <property type="nucleotide sequence ID" value="XM_011320014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S5K7"/>
    <dbReference type="EnsemblFungi" id="CEF74685">
        <property type="protein sequence ID" value="CEF74685"/>
        <property type="gene ID" value="FGRRES_12128"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12128"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05761"/>
    <dbReference type="HOGENOM" id="CLU_2277763_0_0_1"/>
    <dbReference type="InParanoid" id="I1S5K7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF74685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="102" mass="11587" checksum="E93C1243B675D838" modified="2012-06-13" version="1">MGPVGEHHHRSQLQSTTTHATDIGLLSKIYHSIPFITKIIASTENKKQNNYLHAAVIEMWGQPDLSLPRILTSIDHNSRYRHLKTLKSIAIESSRLRDHNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I1S5Q0</accession>
    <name>I1S5Q0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T06315</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318579.1">
        <property type="nucleotide sequence ID" value="XM_011320277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S5Q0"/>
    <dbReference type="EnsemblFungi" id="CEF74962">
        <property type="protein sequence ID" value="CEF74962"/>
        <property type="gene ID" value="FGRRES_12171"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12171"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06315"/>
    <dbReference type="HOGENOM" id="CLU_1896406_0_0_1"/>
    <dbReference type="InParanoid" id="I1S5Q0"/>
    <dbReference type="OrthoDB" id="10293671at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF74962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="134" mass="14856" checksum="24E71C35BD4BC398" modified="2012-06-13" version="1">MYPLSTRPGCEDSVEGFEGRDSGDHDASRASLKKWGRMNPYAYQDHRDVLCLFPSPTQARGAVESFEGKKGGPFRAQVSQVLGTLVPKIFRAAILSTFCDSNSQTRRAKFDVWCFSSGKPCGRDTRARQGWSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I1S5Z1</accession>
    <accession>A0A098DLP3</accession>
    <name>I1S5Z1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T15199</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321204.1">
        <property type="nucleotide sequence ID" value="XM_011322902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S5Z1"/>
    <dbReference type="EnsemblFungi" id="CEF79400">
        <property type="protein sequence ID" value="CEF79400"/>
        <property type="gene ID" value="FGRRES_12262"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12262"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15199"/>
    <dbReference type="HOGENOM" id="CLU_2264018_0_0_1"/>
    <dbReference type="InParanoid" id="I1S5Z1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF79400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="103" mass="11573" checksum="CF5CA174F3543751" modified="2012-06-13" version="1">MILLQSAGNLKRSPQDQVKINDLILQNIESGTTGSSAINCFWWVGGRCSSTKESLLDGRDVVDLHTKHYTARLGSKMVSFSQLWRIRKRLLLTASDRSPRPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1S6G5</accession>
    <name>I1S6G5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T12843</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322300.1">
        <property type="nucleotide sequence ID" value="XM_011323998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S6G5"/>
    <dbReference type="EnsemblFungi" id="CEF78224">
        <property type="protein sequence ID" value="CEF78224"/>
        <property type="gene ID" value="FGRRES_12436"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12436"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12843"/>
    <dbReference type="eggNOG" id="ENOG502SCX2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162806_0_0_1"/>
    <dbReference type="InParanoid" id="I1S6G5"/>
    <dbReference type="OrthoDB" id="2559882at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF78224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="102" mass="10892" checksum="58C52BD6F4552698" modified="2012-06-13" version="1">MNMSGIYENERGQGMSHSTGPSKVPEGIARHAPKGLEEALPDSIHPTGTFPGKSTNKSHAKDSGNASKIPQKLQEKLPESIERAVPNAIHDTGDTSGVHRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1S724</accession>
    <name>I1S724_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG04880.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T16549</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323346.1">
        <property type="nucleotide sequence ID" value="XM_011325044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S724"/>
    <dbReference type="STRING" id="229533.I1S724"/>
    <dbReference type="EnsemblFungi" id="CEF86545">
        <property type="protein sequence ID" value="CEF86545"/>
        <property type="gene ID" value="FGRRES_12647"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12647"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16549"/>
    <dbReference type="eggNOG" id="KOG0029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_9_0_1"/>
    <dbReference type="InParanoid" id="I1S724"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF1">
        <property type="entry name" value="AMINE OXIDASE [FLAVIN-CONTAINING] B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="7">
        <location>
            <begin position="48"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="67"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF86545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="486" mass="54045" checksum="7D7535653EB57B6B" modified="2012-06-13" version="1">MSSKDGYSWTESQGLKSGVPCIGAISPPTNLKNNNTKYDVIVVGAGYCGLTAARDAAIAGLKVLLIEARDRIGGRSWSSNIEGYPYEMGGTWVFWGQAHVWREIQRYNMQNELELSYDFSRGINKYLLVTPEGTQKFTHEEEDQLMQSGLQKLVNVDGQDGRETIVFPHISKLDAIAEKYDRMSIADRIAEIKTDLTYNERICLEAFVLLCSGGTLETTSFYEFLHWWAMSGYSYQGCIEYLVKYKFKGGQSSFAINFFKEALATGNLTYSFNTPVASIKNSPAGVEVTSRSGQTFRARKMISAIPLNVLNDVKFDPPLATGKKAAADIGHVNQCIKVHAEVSDKDLRSMTSISYPHNKLAYGFGDGTTPAGNTHIVAFGGQNNHFHPEENIQTTLDAFQGFTPMKIERLVFHNWSKDEFAKGAWFFSRPGLLADHLGDMRASQGNIIFACSDWALGWRSFIDGAIEEGTRAAMVLRSTLSERSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1S7W2</accession>
    <name>I1S7W2_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Twinfilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG06567.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T22601</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326179.1">
        <property type="nucleotide sequence ID" value="XM_011327877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S7W2"/>
    <dbReference type="FunCoup" id="I1S7W2">
        <property type="interactions" value="405"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1S7W2"/>
    <dbReference type="EnsemblFungi" id="CEF83940">
        <property type="protein sequence ID" value="CEF83940"/>
        <property type="gene ID" value="FGRRES_12937"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12937"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22601"/>
    <dbReference type="eggNOG" id="KOG1747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031995_0_1_1"/>
    <dbReference type="InParanoid" id="I1S7W2"/>
    <dbReference type="OrthoDB" id="10006997at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11284">
        <property type="entry name" value="ADF_Twf-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11285">
        <property type="entry name" value="ADF_Twf-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000042">
        <property type="entry name" value="Actin depolymerizing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000007">
        <property type="entry name" value="Twinfilin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="12">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="12">
        <location>
            <begin position="174"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="299"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF83940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="332" mass="36766" checksum="299199794985B812" modified="2012-06-13" version="1">MQSGISASQELQNEFNSLLSSTGTFGLLATIEKESMVPITTIPSKSSSFSDNLSGLEPHLKPDVALYIILRRHEDAPRFIAITYVPDSAKVRQKMLFASTRLTFVRELGTEHFRETIFVTTPEELSVKGFEKHDAHNKLAAPLTEEEQQLGEVKRAEQEAGQGTGHKAIHLSKNFAMPISDEAIAALKEVGEDGGRPVTMLKINPSTEKVELVPEAPTPSGISELTKAISSTEPRFTFYRFTHTHDGAESSPVLFFYTCPSTPGNKSIKFRMMYPLMKRSVLDAAESQAGLTLEKKFEVEDPSEITEESVLEDLHPKTASRQGFSRPKRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1S9M0</accession>
    <accession>A0A098DPU0</accession>
    <name>I1S9M0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG09314.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T27397</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328446.1">
        <property type="nucleotide sequence ID" value="XM_011330144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S9M0"/>
    <dbReference type="STRING" id="229533.I1S9M0"/>
    <dbReference type="EnsemblFungi" id="CEF83379">
        <property type="protein sequence ID" value="CEF83379"/>
        <property type="gene ID" value="FGRRES_13551"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13551"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27397"/>
    <dbReference type="eggNOG" id="KOG2990">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050402_0_0_1"/>
    <dbReference type="InParanoid" id="I1S9M0"/>
    <dbReference type="OrthoDB" id="360327at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF83379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="349" mass="38824" checksum="84306196F1E784E6" modified="2012-06-13" version="1">MQGFNMGRYVPPDVEGTISANALHKKHPLGARASKPGSLTVRFELPYAVWCSTCPKPTIIGQGVRFNAQKRRVGSYFSTPIWSFRFKHVECGGEIEIRTDPKNTAYVVVAGGAKRDTGEDVPREGDNVIMTDQEREALRNNAFASLEKTIEDREQLVNATLRIDELLEASAKHWDDPYTQNQKLRKAFRVGRKERERDAKATGDLQDRMSLGIDIMPGTEEDARRAALVDFGPVDDGQDRALLKPLFKTEEGKRKPVDSKSGSRLKADKEVSKRKEAFVSELMGNTRAAKDPFLNDGRSEMKGPARLPGVKRKRPVQEAESHTSEPPTKAQAKATETIAPTGLVDYDSD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q4IMZ7</accession>
    <accession>A0A098D3I0</accession>
    <accession>A0A0E0RQL4</accession>
    <accession>V6QXQ9</accession>
    <name>PFA4_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Palmitoyltransferase PFA4</fullName>
            <ecNumber evidence="1">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Protein S-acyltransferase</fullName>
            <shortName evidence="1">PAT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Protein fatty acyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">PFA4</name>
        <name type="ORF">FGRRES_01411</name>
        <name type="ORF">FGSG_01411</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="1"/>
    <dbReference type="EMBL" id="DS231663">
        <property type="protein sequence ID" value="ESU06724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317209.1">
        <property type="nucleotide sequence ID" value="XM_011318907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4IMZ7"/>
    <dbReference type="FunCoup" id="Q4IMZ7">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="229533.Q4IMZ7"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T03467">
        <property type="protein sequence ID" value="FGRAMPH1_01T03467-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G03467"/>
    </dbReference>
    <dbReference type="GeneID" id="23548852"/>
    <dbReference type="KEGG" id="fgr:FGSG_01411"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03467"/>
    <dbReference type="eggNOG" id="KOG1314">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027721_8_1_1"/>
    <dbReference type="InParanoid" id="Q4IMZ7"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="PHI-base" id="PHI:1673"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03199">
        <property type="entry name" value="DHHC_PAT_PFA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033682">
        <property type="entry name" value="PFA4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000212967" description="Palmitoyltransferase PFA4">
        <location>
            <begin position="1"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="195"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="DHHC" evidence="2">
        <location>
            <begin position="87"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="377"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="active site" description="S-palmitoyl cysteine intermediate" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="437" mass="50754" checksum="A7486063B0138437" modified="2005-08-16" version="1">MAGLNDVPFIKGLAVPSVCALIIFLGYASQFLFNYSTTLEPGPPTRRETIIFNGLLLVLWITYYRTVATDPGRYIFKDRVIEAEGQRWCNKCAAPKPPRAHHCRHCARCVPRMDHHCPWTRNCVSMTTFPHFLRFLIYTNMSLWMLGYFLWQRFSKIWEHRRLPAYLGPSFYGLICLSLISIVNFVTTVALGIMLINTVKSWVFNQTMIEGWEQERHEALMDKGPKEWWDIMGPDGEKVRFERLEFPYDIGFFSNMAQAMGTHNVLLWFFPFAGNPTVAKDGNGQGWTWEENGFNRIEGLWPPPDPDKLRRAARGWPAGNRNYAEELRQANMSSSEYKAGFLKRQADDEKRKRHLMAELEEVDDFDMYDDEEYDRELDQGLGWVNSDGDRLRDYGVDEEASEPEGVNDDDDDDDDDDVPLAELIRRRKILKKDGLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>V6R3D6</accession>
    <name>V6R3D6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG04636.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T15763</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320936.1">
        <property type="nucleotide sequence ID" value="XM_011322634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6R3D6"/>
    <dbReference type="EnsemblFungi" id="CEF79681">
        <property type="protein sequence ID" value="CEF79681"/>
        <property type="gene ID" value="FGRRES_04636"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04636"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15763"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="InParanoid" id="V6R3D6"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF42">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="24"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF79681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="535" mass="58796" checksum="7BE434391D97F03E" modified="2014-02-19" version="1">MGWNTHASGTNDPPEVRNWRIHLIATVASMSALAIGYDTSVIGGTMALTSFMRDFGLDLVEKTQRDTIQGNIVSTFQAGCFFGALCTFPIAEKWGRRKTIMAAACIFLLGGALMTAANGNLNMIYAGRAVAGLGLGASSLTVPVYISETAPPSIRGRLIGIFEIASQGGGMLGFWINYATDRTIDVNTKTQWIVPLGLQLLPGAGLALGMLWCPESPRWLARGDRFEEAEKILSQIRGMTPDHEYIRREMGDIRAQVEERSTNKMSKKQMFMKLFQKGVRNRMGIGMALMFLQSFTGVNIITYYAPRIFESLGIPGTSLKLFSTGFYGISKTLGMVLFTFWVVEKVGRRKGLIWGAALGCIPMLYIGGYVMKADPAAAAAAGVVNRDGWGYLAIVCVYINAIIICATWQGITWTYASEIFPLDIRMLCVAITTADTWLGSFIIARSTPYMISDLGYGAYFFFGSILVLMGIWSLFFVPETKGITLEDMDALFAKPVYKTVWAQMRGKPVLEGNAANRSDSPFDEDDEKARELRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>V6RFX5</accession>
    <name>V6RFX5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG06967.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T23631</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="229533.V6RFX5"/>
    <dbReference type="EnsemblFungi" id="CEF83600">
        <property type="protein sequence ID" value="CEF83600"/>
        <property type="gene ID" value="FGRRES_06967"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06967"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23631"/>
    <dbReference type="eggNOG" id="ENOG502RYP8">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042838_1_1_1"/>
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    <dbReference type="OrthoDB" id="414418at2759"/>
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    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF83600.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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    </evidence>
    <sequence length="294" mass="32107" checksum="DF6D9C25BD65AB45" modified="2014-02-19" version="1">MSLEVIYVTRHGFRSGWSVDPLTGVYTATIRSPTGIPADPALTSYGVSQAKEMGKHLMTLEPPIDVVYSSPYYRCLQTITPFIELKQQQLEEEPGTTHGSATATIRPEHGLGEFFGAAPFDHPIPASHKRLKELFPAYDDSYVSAIKPSRKGETIENLYGRVAVAMRGIVERCDAEGKRAVVLCTHAAVVIALGRVLTGRVPEAVEEEDFHAFTCGLSTYRRRRQGTGTQVPSTDESQPFISKAIPVGLGEWQCELDSDCSFLSSGEERGWRFSGDESFPGTGSMSQGGVESKL</sequence>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A098D0T0"/>
    <dbReference type="EnsemblFungi" id="CEF72047">
        <property type="protein sequence ID" value="CEF72047"/>
        <property type="gene ID" value="FGRRES_15055"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00493"/>
    <dbReference type="InParanoid" id="A0A098D0T0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="20"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF72047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="86" mass="10196" checksum="C366AD9401E22116" modified="2015-01-07" version="1">MEKEKREEEDDDDDDDDDGIINLQNLDGMVKLQQRNKVEEAKMLLSLVDKAKNASKYFDSRHLRKLRLDMPVELNKLHLISLYKLH</sequence>
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        <recommendedName>
            <fullName evidence="3 13">Cutinase</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cutinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3 13"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D6N4"/>
    <dbReference type="EnsemblFungi" id="CEF74619">
        <property type="protein sequence ID" value="CEF74619"/>
        <property type="gene ID" value="FGRRES_02342_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05629"/>
    <dbReference type="InParanoid" id="A0A098D6N4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000235">
        <property type="entry name" value="Cutinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043579">
        <property type="entry name" value="CUTINASE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF3">
        <property type="entry name" value="CUTINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00931">
        <property type="entry name" value="CUTINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 13" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="70"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="211"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CEF74619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="248" mass="24742" checksum="24CEB193712F698F" modified="2015-01-07" version="1">MASARPAGDVEARQFGSGLGSGLGSGLGSDLGSDLGSGFGGLSGGGLGGGLGGLGGSTRNDLEQGAAGSCPKAIFIFARATTEQGNMGMSTGPAVASKLEAKYGKGGVWVQGVGGPYTADVPGNLMPDGSSPAGINEAVRLYNMAHEKCPDTPVVTGGYSQGTALVAAAISKLDPKVMDQVKGCVLFGYTKNAQNNEAIPNYPKDRTAIYCNVGDAVCTGTLIITAAHFMYQADAAGPAPEFLISKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D6W9</accession>
    <accession>A0A0E0RSH2</accession>
    <name>A0A098D6W9_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11 12">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 11 12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FGRAMPH1_01T04781</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11 12">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 11 12"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D6W9"/>
    <dbReference type="SMR" id="A0A098D6W9"/>
    <dbReference type="EnsemblFungi" id="CEF74197">
        <property type="protein sequence ID" value="CEF74197"/>
        <property type="gene ID" value="FGRRES_15917_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04781"/>
    <dbReference type="eggNOG" id="ENOG502RXA7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098D6W9"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Endo-1,4-beta-xylanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF3">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <keyword evidence="5 11 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010018616" description="Endo-1,4-beta-xylanase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="15">
        <location>
            <begin position="34"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="214"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CEF74197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="276" mass="29116" checksum="EFB20CE5BAEF5792" modified="2015-01-07" version="1">MVRITSIFAGLSLVAGSIAAPSPEGMFSTLAKRGGTPNSSGMNNGFFYSWWSDGGAEATYENGAGGSYSMSWQTGGNVVGGKGWSPGKARTISYEGEYKPNGNSYLSVYGWTRNPLIEYYIVEDFGTYDPSSGAQSKGTVEVDGSTYEIFTRTRTNAPSIDGTQTFEQYWSVRKNHRSTGSIDVGAHFKAWEQHGMKLGTHDYQILATEGYLSSGSSHMTVSEGASSAGGAATNGDSAAKPDAGNGQGQNQGNGQQQPGSQPQPQQQAAEESCKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D873</accession>
    <accession>A0A0E0RSD6</accession>
    <name>A0A098D873_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG01950.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T04709</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D873"/>
    <dbReference type="FunCoup" id="A0A098D873">
        <property type="interactions" value="1476"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A098D873"/>
    <dbReference type="EnsemblFungi" id="CEF74161">
        <property type="protein sequence ID" value="CEF74161"/>
        <property type="gene ID" value="FGRRES_01950_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04709"/>
    <dbReference type="eggNOG" id="KOG0103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098D873"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24094">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000011">
        <property type="entry name" value="Heat shock protein hsp88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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    </evidence>
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        <source>
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    <accession>A0A0E0RUQ0</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblFungi" id="CEF74975">
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        <property type="gene ID" value="FGRRES_02642_M"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A098D945"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF74975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74975"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="311" mass="35679" checksum="662B46734BA356C8" modified="2015-01-07" version="1">MERIPKDCAPSCDHTLTAESFSSHWGQGWASRELVLSEAEKILPPYEQAKACMSRQGVHELYRFLKTFRWVSTASRPSNHQAYRYFRGTAPSRPNQPVRYYPYYFLLQSPFPGSEAVKKMCLDMEHHWGVRLDYRQPFYPRLDDPEQERKLIMGDVEPGLSTDQSIADPSESNQEPNDTLPPTDDQLGSNSNNGVFQNYEEQLSAIRSDFKKRISDLQSNLELDRDVAEIGVDSQRHREKDREKVEEIHHHAVQAQKCTEQALEYAEKAQEHANASVELVQLLMESMSSSNLSVGRSSGSDRPSSKRLREN</sequence>
</entry>
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            <fullName evidence="2">Chromosome 1, complete genome</fullName>
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        <name evidence="2" type="ORF">FGRAMPH1_01T07639</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
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                <person name="Chang Y.-L."/>
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                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CEF75623"/>
        <property type="gene ID" value="FGRRES_15587"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF75623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="63" mass="6994" checksum="8217B03F23914878" modified="2015-01-07" version="1">MVTVTVTAGIKISITITPIPMGEQIPYQDLPQLQNMRRQLSLPPRAMAGSAKRENPSSYRPEN</sequence>
</entry>
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    <accession>A0A098DC99</accession>
    <accession>A0A0E0RXV0</accession>
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            <fullName evidence="2">Chromosome 1, complete genome</fullName>
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        <name evidence="2" type="ORF">FGRAMPH1_01T08545</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF76075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DC99"/>
    <dbReference type="EnsemblFungi" id="CEF76075">
        <property type="protein sequence ID" value="CEF76075"/>
        <property type="gene ID" value="FGRRES_15616"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08545"/>
    <dbReference type="InParanoid" id="A0A098DC99"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="86" mass="9399" checksum="5F0590D4650F9714" modified="2015-01-07" version="1">MHPVNLTHENPQGQGQGFLGALRVQIRHPGGCFEMAHLSAMSDSAKTRSKVRRAMSDSIPWMVGGKANSTQETTDPADRNNLQLAR</sequence>
</entry>
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    <accession>A0A098DE19</accession>
    <accession>A0A0E0RZL7</accession>
    <name>A0A098DE19_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
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        <name evidence="3" type="ORF">FGRAMPH1_01T09779</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DE19"/>
    <dbReference type="EnsemblFungi" id="CEF76692">
        <property type="protein sequence ID" value="CEF76692"/>
        <property type="gene ID" value="FGRRES_20124"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09779"/>
    <dbReference type="InParanoid" id="A0A098DE19"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF76692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="87" mass="9707" checksum="02D88CA71CFAD757" modified="2015-01-07" version="1">MPLVPSSAPLPGSMTTFAYLREQKILNIVYVGLLVVEVLMVLGVISVALVKRVKAHRRPKAIRPVTPLTNYPPHQYMHFGNEKPTKS</sequence>
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        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
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    </protein>
    <gene>
        <name evidence="3" type="primary">FG02842.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T11439</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DGE0"/>
    <dbReference type="EnsemblFungi" id="CEF77522">
        <property type="protein sequence ID" value="CEF77522"/>
        <property type="gene ID" value="FGRRES_02842_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11439"/>
    <dbReference type="InParanoid" id="A0A098DGE0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="131" mass="15420" checksum="0AA5000667DDA18D" modified="2015-01-07" version="1">MTSTRMSFETEAQQADRPYTPWDDMVLPTVYSWSDLEEVKDDNGLEVEPSHQYSSGQNGAECTIEEEMNERQMIDAPVRHLRDCRIDPDDDWSDYEADDESDNECDDGYESDDTEMWAEKHHLDWLSYHQD</sequence>
</entry>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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            <taxon>Fusarium</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CEF78063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A098DGJ4"/>
    <dbReference type="STRING" id="229533.A0A098DGJ4"/>
    <dbReference type="EnsemblFungi" id="CEF78063">
        <property type="protein sequence ID" value="CEF78063"/>
        <property type="gene ID" value="FGRRES_03294_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12521"/>
    <dbReference type="eggNOG" id="ENOG502SK98">
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF78063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="659" mass="73876" checksum="815AB4AF0CA922EF" modified="2015-01-07" version="1">MSDSQYDSDGTENRRKRIPQACLNCRRKKVRCTGEKPTCGFCARLSQRCLYVEDRRNLKRPSSALSTGDEEVIGASMHTITERFAILENQISTLQSTIEKLLPLVENRSAESTRRSLDQVNTPATAILQTPSTIQSQASDRPQLQALIYAADIYFCFCHSQPYSLFHEPTFRQRLADNSLPSYLLWAFLSAARRYSTFPVAPLNCADDASAYAAKAWECIELPWSGSDSPEKILTVIQTIILIVSTEVPAGHCTQAHMKLGFAVRLAQNNKLNLEPDASKTVFEREELRRTFWSLFLIDKLISLSRGRFCAIRDEECKLSLPCSEKAFREGIAEHTPTLEELTRDCVDQEAVDGCCPLGLIVVMVSILGRVSHYVLHDTQTPQVAWSSTSPYATLSSTLLQAEHYFAMDEDTMDSLKKRCTIDGNLDQHLAGSFIFAKAMFHLSQCLLYHPFLIQQHLQSGKQKAPSIFMKEAWEKCRTHAESITKLMEMKTQNVLVLTSMYGYCIMVAGTIHALSMNDERENVRNESKEHYSASIESLQDLSRYWPHAALMVKRLERFHNQCETRGQELSPCNSNVERPAGHVKALWQSVDYTSLSTPTRPGSPTPAAQTTSQDDWALSGDMFDFTGFGGFAEGVDIFSISLVDGDMTLDGEMPAIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DH12</accession>
    <accession>A0A0E0S434</accession>
    <name>A0A098DH12_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T12913</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DH12"/>
    <dbReference type="EnsemblFungi" id="CEF78259">
        <property type="protein sequence ID" value="CEF78259"/>
        <property type="gene ID" value="FGRRES_16265_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12913"/>
    <dbReference type="InParanoid" id="A0A098DH12"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="3">
        <location>
            <begin position="35"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="315"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF78259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="434" mass="48158" checksum="E82129508959FF12" modified="2015-01-07" version="1">MGTPSLGADSLIDQAESFKAFLGLNQPEPGDRFFLVMGLTGAGKSTFISNCTGHNVVVGHGLYSCTNSIGVYQYTSHGQRIFLIDTPGFNDTTRSDIDTLEILATYLGASYANGVRISGIITLYPISNNRMAGSNLRSLAILNAVSGFASNDNLAIVTTMWPESSSSIEKTILEERELELLTKYEFFGDLVNRGAATFRHYDRGYSKVGSARRIVDSLARKLNGHSPGVLQLQREVVDEKKNLGETTAGIAAAEYLYKARLEHDNHLKQLNTELERTSTGSDEEYYLQLLELKAEVDKEIQQTEQGRQALVKTMVDLHQTETKSLKQRISNLQSQFEAEVQNNEMMLRDVQESYDALQKEVARLTNHPQQQQLVARRTKPHQKALRKAQKDAEKSRRDHQRVQEYTKEIVGGVMNGIAASAVAGVMGGLMCTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DN14</accession>
    <accession>A0A0E0S9Z8</accession>
    <name>A0A098DN14_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T24815</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DN14"/>
    <dbReference type="EnsemblFungi" id="CEF83261">
        <property type="protein sequence ID" value="CEF83261"/>
        <property type="gene ID" value="FGRRES_20369"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24815"/>
    <dbReference type="InParanoid" id="A0A098DN14"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF83261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="144" mass="16657" checksum="1E1E235D384DA9CD" modified="2015-01-07" version="1">MLGGRNWNWLWPNLCIPTHVSPDTEVKMERLEAFIMCFKSLNSIMSLYHEGGVLIDVAGDYLRSLMRDPQGLEGLYLINCLMNRGIDSQFLEKIITLNVWRLKCMKKDNHLGGHVFVRQVCRVFEEILSTFVIAVDRLTRLNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DNV7</accession>
    <accession>A0A0E0SAP2</accession>
    <name>A0A098DNV7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T24799</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DNV7"/>
    <dbReference type="EnsemblFungi" id="CEF83505">
        <property type="protein sequence ID" value="CEF83505"/>
        <property type="gene ID" value="FGRRES_20368"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24799"/>
    <dbReference type="InParanoid" id="A0A098DNV7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF83505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="88" mass="9564" checksum="17561083D8A5681F" modified="2015-01-07" version="1">MSLYGATCCMPSNAQLSVAASTWPGRAAIAHAVHALPLQSSQASDLSTVGNELIAHLIRWEKYSWQACVLIFTLRTLFWGHSIYNAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-06-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DP18</accession>
    <accession>A0A0E0SAZ3</accession>
    <name>A0A098DP18_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T24567</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DP18"/>
    <dbReference type="EnsemblFungi" id="CEF83606">
        <property type="protein sequence ID" value="CEF83606"/>
        <property type="gene ID" value="FGRRES_13125"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DP18"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF83606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="128" mass="14201" checksum="DA78302196DE153F" modified="2015-01-07" version="1">MIKFEGNNNRWYSLGNHLTPTGPAPRPARHFEDEAPQAATSIFQSRQSTRGDYAAHLHRVQRLRDGIRSRAKRQFAAQRPSKGVLGIHAKIADPIDSGTRHDVVHLSSVVISRSREAGSTSTHDRGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DPC2</accession>
    <accession>A0A0E0S9V6</accession>
    <name>A0A098DPC2_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG09004.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T28143</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DPC2"/>
    <dbReference type="FunCoup" id="A0A098DPC2">
        <property type="interactions" value="411"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A098DPC2"/>
    <dbReference type="EnsemblFungi" id="CEF83219">
        <property type="protein sequence ID" value="CEF83219"/>
        <property type="gene ID" value="FGRRES_09004_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G28143"/>
    <dbReference type="eggNOG" id="KOG3964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DPC2"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
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    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF83219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="522" mass="58222" checksum="89ED7648F3B888B9" modified="2015-01-07" version="1">MFARSCVRCTTTLRAARIRPRIPSGRVQTRQYAMPAGGASASNSNGAGALAPFVTELDRLAPSFDIRGEQIRIIQTPAQFYETLKERIRNAKRRIFLSTLYIGKSEKELIETLQESLRKNPDVKLSILTDALRGTREAPNPSSASLLAPLVEEFGANRVEIRMYHTPNLTGLRKKYIPTRINEGWGLQHMKLYGVDDEIIMSGANLSTDYFTNRQDRYHLFSSKEVTDHFWSIHSGVTSFSFLVQPSKEPAGFTLAWPENNSAPSPLEKPESFVKSTTSTLQTLLHPKSKPENDISDTRVYMLGQMSQVMKPDTSTELPIITHILKTLALPAYRDSSWTFTAGYFNPAPSLTKLLLGTASSSNTVITASPEANGFYKSKGVSGLLPDAYTLLARRFVHRVHHEGRDNDITLKEWRYGVVGQPGGWTYHAKGLWVTMPGDSNPAMSIIGSSNYTKRSYSHDLEAGALIVTRDEGLKTRLGEEQLWLQEHATKATRDDFARTERRVGLKVRVAMWIVSLVGGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DPF9</accession>
    <accession>A0A0E0SBC8</accession>
    <name>A0A098DPF9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG07786.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T25663</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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    <dbReference type="STRING" id="229533.A0A098DPF9"/>
    <dbReference type="EnsemblFungi" id="CEF83741">
        <property type="protein sequence ID" value="CEF83741"/>
        <property type="gene ID" value="FGRRES_16896"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25663"/>
    <dbReference type="eggNOG" id="ENOG502QTAT">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A098DPF9"/>
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        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
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</entry>
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    <accession>A0A098DPY8</accession>
    <accession>A0A0E0SAG1</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DPY8"/>
    <dbReference type="EnsemblFungi" id="CEF83424">
        <property type="protein sequence ID" value="CEF83424"/>
        <property type="gene ID" value="FGRRES_20408"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G28257"/>
    <dbReference type="InParanoid" id="A0A098DPY8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF83424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="73" mass="8804" checksum="E734102B86E8F976" modified="2015-01-07" version="1">MQYCVWHGSKVRSETQKQQYQLARDLTLDKGLDLELLYSDQDAQFYIDHGIMEGVARRWVRDVKLFLDQYDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2024-01-24" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DQ24</accession>
    <accession>A0A0E0S965</accession>
    <name>A0A098DQ24_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
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    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T24611</name>
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    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF82978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DQ24"/>
    <dbReference type="STRING" id="229533.A0A098DQ24"/>
    <dbReference type="EnsemblFungi" id="CEF82978">
        <property type="protein sequence ID" value="CEF82978"/>
        <property type="gene ID" value="FGRRES_07353_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24611"/>
    <dbReference type="InParanoid" id="A0A098DQ24"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF82978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF82978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="409" mass="44871" checksum="AFD097F5C84BDA53" modified="2015-01-07" version="1">MSDSTGPPKGKPYVAKKPLLPRHVHGVVVVEIATASAILARSDCSNQNAVVVSKQSQATTGVAEDGKHSAVKRKNTMNYYPGAGGLAAVASATVTGLDKVIVQRTHVPTTKSQLGQKVMEATKTPAHGADAKHSAVNTTRKPLPVPGIGLKLRGALRNEAERVVDEESSAGSLRWARIITLPMNDAKASCFATKLEVVSRNDLTKKQIEASVDTDHNPDLQYATALLETAMTGILPNGTHMVTEAIDYKDIYDYWSKDVLPKLPSAGSSRVVKSPNDYFMDRWGSKGNRSPFLLLDLQDPSLFAKLLKATIQGGNGHDGILDPIKWISGAVPRLRRLHEIHQEFDYNWYRARTDNARKWVIEQLDLIENAFQKASPVPANYKTVMDTVAEFKTEARLIRPPPEDPKKYH</sequence>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DQZ7"/>
    <dbReference type="EnsemblFungi" id="CEF83777">
        <property type="protein sequence ID" value="CEF83777"/>
        <property type="gene ID" value="FGRRES_15378"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22951"/>
    <dbReference type="InParanoid" id="A0A098DQZ7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF83777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="53" mass="6023" checksum="F39FA1722853FE08" modified="2015-01-07" version="1">MAAGQRITAARERKTMLIDVDVMEKMRGNRADVLKGKRLAEIASNLSFRLCRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DVN3</accession>
    <accession>A0A0E0SHP8</accession>
    <name>A0A098DVN3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG11267.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T21649</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF85961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A098DVN3"/>
    <dbReference type="STRING" id="229533.A0A098DVN3"/>
    <dbReference type="EnsemblFungi" id="CEF85961">
        <property type="protein sequence ID" value="CEF85961"/>
        <property type="gene ID" value="FGRRES_17581"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21649"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DVN3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET_dom"/>
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        <property type="entry name" value="SET_dom_sf"/>
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        <property type="entry name" value="Znf_MYND"/>
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    <dbReference type="PANTHER" id="PTHR47332">
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        <property type="entry name" value="SET-6"/>
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        <property type="entry name" value="SET"/>
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        <property type="entry name" value="zf-MYND"/>
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        <location>
            <begin position="7"/>
            <end position="150"/>
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        <location>
            <begin position="475"/>
            <end position="515"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF85961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="547" mass="61685" checksum="0AF8028FDDEC431E" modified="2015-01-07" version="1">MSGLVEEPMTELQEVPGKGQGLIATRKIPKGTRILSEKAIIRVPEIFANIAAVSASIGRQVDSLPPDQREAFLSMCNIYPSDDDTSPYLGIVRSNGLPMDFGSGVFLQASRINHACDNNAQKDYNEGIKRHTVHALRDIEEGEEITITYLGILKNRRTRQQALRTKFMFTCTCNLCSLPDDLSAESDRRLDEILALEDRIARAGITGMLSNPKRMLGHVYQQVQLYKEHSLDDIGLPRAFFDAAQIVVTHGDLARARVFTERAAAAWRLIRGDDDPHVIKTQKLALDPSTHTTYGHTAQWKTAFDQVPQGLNRDDFEAWLWKREKLPEVGAFRNQDMFPSFLGLPSDNVMERDFFKIKDGRNFRPRRHWCFLAEIVEHSDSSRLQMTVKDVTGKTLPIIFYTGTHESEVVASQIREGYTVAVLYAEQHAFVYEEVGIRFEKPTLLKIFPVALDDLLSLSDRVHKYSTVTNGMRTCHGCGKQGASLKKCAKCSMFWYCNGACQKAGWAEKDHKEDCTLLQDGDLKGLLSLNEDKFESRVKFPMNTGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DXI2</accession>
    <accession>A0A0E0SHX4</accession>
    <name>A0A098DXI2_GIBZE</name>
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        <submittedName>
            <fullName evidence="10">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FGRAMPH1_01T20833</name>
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    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DXI2"/>
    <dbReference type="STRING" id="229533.A0A098DXI2"/>
    <dbReference type="EnsemblFungi" id="CEF86037">
        <property type="protein sequence ID" value="CEF86037"/>
        <property type="gene ID" value="FGRRES_17496_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20833"/>
    <dbReference type="eggNOG" id="ENOG502RXKD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DXI2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021013">
        <property type="entry name" value="ATPase_Vma12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11712">
        <property type="entry name" value="Vma12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011844221" evidence="8">
        <location>
            <begin position="16"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase ESCO zinc-finger" evidence="9">
        <location>
            <begin position="491"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="298"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF86037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="542" mass="60108" checksum="4407D54BAA131687" modified="2015-01-07" version="1">MVLLTMTSSIVEALANVQPPETPDSEDHDIENETQESPQPTNEPSLDDPQIGKPISHGQIVDLWKRSKAQDDANYTLEQLLRGASVYIPPPPPKPEPSPEYKALMARLRRQEEARSYERMMNPAPKHETFKDRYPFSAAAFAEANRPTSASDIGEEDIAMEEVHKQVTLIINFLVSIAGVAGTLWVTARWWSLPARLFLTMGGSILVAIAEVVVYNAYLWKMDEGRKKLGKVKEVREVVESWTVGKLDDEDEKTILLKEKDDTGVSKSASEGLNKRPWRMLQSQLSQVDYGEICCSLRSRSENPTPSTSRPRAKPLRTYGKRSTRDDSPRETSLKKRRISTATTPAETSASKDTDKEAQSLPTIAPEETESAVESTSKPAKKGSILSFFKPVPSSSTAASSPKSDEPQPESPPSSPPARIEIRKKPRLLRFRGTSLPLLKGENTEDDDQTGEAKEESTTPASRESSLNRESNNGNDVKVGKKGKAKSSAVQMTLNLSSQAAFSECKVCNTVWNPLCPDDVKFHIKQHAAILRAKRKEKENEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DZF1</accession>
    <accession>A0A0E0SLB3</accession>
    <name>A0A098DZF1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG11356.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T21861</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DZF1"/>
    <dbReference type="EnsemblFungi" id="CEF87226">
        <property type="protein sequence ID" value="CEF87226"/>
        <property type="gene ID" value="FGRRES_11356"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SN6I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DZF1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF87226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="535" mass="61135" checksum="BB6BE6C463D2AE7C" modified="2015-01-07" version="1">MGQCKRMRVKCDETKPTCTKCLKANRSCQYWQSSTKLHLTASQQKILLPKDDALSHTESNLLLIQPRATSLTAHEAPYFDLFRHQMAHDFAYTPCTLFWNRVIPREAMSDECVRSSVLSIGALMQSLYRLGPKPYTSLIPSSGRSRASHDETYRIALRYHSKAISALQARMRNNFATVSRRNILINMFLLFLFELMHGNTAAADRMLTSSNELLKQKGDHLLSEVSAGFQQQPQPMYTAPSNDEGLDQAERILPRLQVFLSLNSRFYPLQKDCWSRFSAKATRSQVPSLMADFVQFGAAWNSFITRAVIFVVKTMQEAPSLEPAQLTTLANYRNTFLRELKQWERAIVQRSDREANFVVKRTLKIFHVGQKVVHILLSCCFDSTETEYDNHDSTFSDIMVMMHSMADESQPATRIETVLDIYVLPVLNFVSQKCRNSSTRLDALDLFEKMVSQMGGWETRASLLARRRLMDLEELGRTESGDIPAEGRYIWTDACWDEARTCLNVSFQNAGLRKLGQTDPRGLIKIKISLKEFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098E420</accession>
    <accession>A0A0E0SN20</accession>
    <name>A0A098E420_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T16155</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF87833">
        <property type="protein sequence ID" value="CEF87833"/>
        <property type="gene ID" value="FGRRES_12595_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16155"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098E420"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="3">
        <location>
            <begin position="38"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="564"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="597"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="630"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="850"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="713"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="889"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF87833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1713" mass="190842" checksum="43EBD42BFE98785F" modified="2015-01-07" version="1">MASQGLPTGRKITGKAREPCYYIPFTKNIHFTGHATILNALEDAFFGQEQIQRMALAGLGGVGKTQIALHFAYQVKDKWPEYSIFWVPVLSNEGAEHAHAEIAKKLGLQKESEDDDVKRLVCQHLSSAKAGKWLLIVDNADDHELFLGSADKPGLEEYLPQSENGMILLTTRSTQVAGEFAQYDVIEVKQMNNEEAMSLLETSLVQKQPFYDDAVATELLTYLTFLPLAITQAAAYLNQTRAPLQTYLSLLKNAENDTRVLEIEFRDNNRYRDSQNAVGTTWIVSFRQIQKSDELAVKLLSFMSCIEPKAIPQSILPNEIRPIDLQSAIGTLCSYAFLVRRGQSNVFDMHSLVHVAMRGWLKKQGLENQVTHDAICHLAARFPTSSDAHHDVRREYLPHAIRLLSRNSRQNVDETYRLIEKVGASFKTDRKFKEAVKCFEEVYLWKQGLLPKKDHSRLASEHMLASAYLNTRQIKDAIKIFEHVVEVQRETLDEKNHSRLTSEHGLASAYLADRRIEDAIEILKHVVEVRKETLDKEDHSRLISEHSLAVAYLAARLIKDAGFDELTALQTASEGGHLEVVEKLLAAGADADSKDTDGRTAFQVACEAGHLEVVEKLLAAGADADSKDTDGRTAFQVACEAGHLEVVEKLLAAGADADSKDTDGRTSLSWAAEKGFQAVVELLSAQNSDNLRSLSGDLSTDTGSDVSNDSSVFSISSSVPSTTPSSLPGSENVDNAAAEHLAYLLSEDLFLRPLYSQALKAMDKDRFFRNHDRLLKKFMIELRCRAEDDMVIQVVRVLRNQRQRERVTTQIYHTFQPDTANTNRKGMRDFLDQKEDRKYRLKVFFEQRDHERGTAGRDNVPEANSSGPAAADVKVEEEIHENEESGSAPDEEVEDEDEGEETEDESEDAPNASQRLDLVVDFITSSPPFEAFKSNLHYFVNPPTTIKEAIGSNSIKALKQLLRNRFDLLATGEYSWLQELNDMGLDHDEMADLLFQQATDSPWIYFEPGAISPTEIKIGHHLHGCVHQLNLSNKPKPGSTASHQGSFQTGDWSDYVRTIQELCGLGGIAPKTRCLEKWNGSVTFEEDHSTACVSYAHQDEQVVFSRVANALHQFCIAIGHAQSAGLCCDSFTILKNPGRHPNDRSSLIEVCRIDFHLAVTMLDELEQLFSAKDTPDFGKPRSLEVLDILLEGASIGPSPETLTEALHLYSLAVQILCLGFLSYSQAHVGPLRPFFLDTLVTKVRLLGIETSSAPYQYIDAGLKELTCFGNMVEGPVLAFSVVTPKPSTPSPIDLRSGFDLLTSAQDLVDTWGPGQFVVPDGKKHPSAIRIGGGFVYLCTSGQDSGKFHWSRTVTSGLFCYGEFDLRRKIVIGARVTVNDACGLDESSCRASLSGHLQPLGTSLPGWELKEVQVGGQIGNYGLVQANASYHMFPGQTLKKKRLDVDDGELILFLEELWGVQMSLCTAVARRVLLHEMIADLLPVFARRLTSGDECRLWKDLESHRFIIENFRSGKLLGWVQELPPPAHNLVLKLVRGILNTLQDTGLDRNGKALMVAWPYGNDSCHGCRIACEGESSWARALADSHDSATFAYISAACLETEEIKCSGKSWQWKNTIPLLETAVTVEMTSTSMLTETLQNERIYSFRMLQNPLLVKARKPNTSGMIMLVEKKSKIPAQVRQRWNEIMRTHKVLREKRGAHDRAELVVVLSIQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098E4D0</accession>
    <accession>A0A0E0SNF5</accession>
    <name>A0A098E4D0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG05246.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T17453</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098E4D0"/>
    <dbReference type="STRING" id="229533.A0A098E4D0"/>
    <dbReference type="EnsemblFungi" id="CEF87968">
        <property type="protein sequence ID" value="CEF87968"/>
        <property type="gene ID" value="FGRRES_16465"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17453"/>
    <dbReference type="InParanoid" id="A0A098E4D0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF87968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="415" mass="44894" checksum="8CF74C8F1BF69036" modified="2015-01-07" version="1">MPRDSSPQADPALDTPVRQTRARSKLTNASPLMRGLDHRGRPQGPLIEKPKPKPKPKPKPKPKPKAKPEPKVAPKSKGSLKPAIKKASNKLRRKQKVAFRAQASHVSDNESENSPVEEEEDDDAQDAADNDDDNSNDAPPAQNNDDQVPDEEDSEMSDALDSPDSDDSEPPSPTQNPEDGTNDDSPESSTSPENNNNSGLPDAPDAPAPTPTANQGDDSGNAPVDGDNADPVEHVSDPEESDFSDNSLSASEPAAHAKVLTPISVPSSGNLSPLIMPHLDPEIPGLYSSGVRARPHYGWYEQYHLTGLDCAKVHGCTHNPGRVCHSCHADWHKAWSVYFKAHEILDEAVANSEQYLTDTGVDVRKDYLGHLLEGSGWEVLALELQPPTGNSIRLHPTRIAKHRLALAQVATDMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RQT8</accession>
    <name>A0A0E0RQT8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG01473.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T03615</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
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    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1</strain>
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    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
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    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
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        <property type="protein sequence ID" value="CEF74810"/>
        <property type="gene ID" value="FGRRES_02504_M"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06011"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
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        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
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        <property type="entry name" value="L-lactate/malate_DH"/>
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        <property type="entry name" value="Malate_DH_AS"/>
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        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
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        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MDH"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
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            <end position="146"/>
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    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
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            <begin position="148"/>
            <end position="323"/>
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    <feature type="active site" description="Proton acceptor" evidence="8">
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            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="8"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
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    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
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            <dbReference type="ARBA" id="ARBA00048313"/>
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    </evidence>
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            <dbReference type="PIRSR" id="PIRSR000102-1"/>
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    </evidence>
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            <dbReference type="PIRSR" id="PIRSR000102-2"/>
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            <dbReference type="PIRSR" id="PIRSR000102-3"/>
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            <dbReference type="RuleBase" id="RU003369"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
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            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CEF74810.1"/>
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    <evidence type="ECO:0000313" key="16">
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            <dbReference type="EnsemblFungi" id="CEF74810"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="330" mass="34423" checksum="CC3BA9EE287FA93C" modified="2016-04-13" version="1">MVKAVVAGASGGIGQPLSLLLKTSPHIDELALYDVVNTPGVATDLSHISSRAKTTGYLPANDGAKAAFKDADIIVIPAGIPRKPGMTRDDLFNINAGIVKGLIEVAAEVAPKAFILVISNPVNSTVPISAEVLKAKGVFNPQRLFGVTTLDIVRAETFVAEITGKANPQELTIPVIGGHSGETIVPLFSKASPSVQIPDDKYDALVNRIQFGGDEVVKAKDGAGSATLSMAYAGFRFAEKVLRAVKGEKGLVEPSYVYLPGVPGGEAIAKETGCDFFSVPIELGPNGAEKATNPFEGITEKEKALLAKATEGLKGNITKGVSFVHNPPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0S3U3</accession>
    <name>A0A0E0S3U3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T12731</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0S3U3"/>
    <dbReference type="STRING" id="229533.A0A0E0S3U3"/>
    <dbReference type="EnsemblFungi" id="CEF78168">
        <property type="protein sequence ID" value="CEF78168"/>
        <property type="gene ID" value="FGRRES_16283"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12731"/>
    <dbReference type="eggNOG" id="ENOG502SQ1J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0S3U3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="201"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF78168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="655" mass="75137" checksum="4941B6E825E56CB9" modified="2016-04-13" version="1">MGKLCEHCAIILSLQVEPEAWSQDFTLHSIDDYAPLKHFRTVKELIESAENCRLCDFIEASWSLPALHKRYPDIKEQDYGSLKLEFKITKAVSDPSGVSCNFIGGDIIVPWHGFADSFKVTITTCRVGTDVSHLPIWDYKELTNEDRIKTIKGWYTECSSQHAGCKPSSLGHPRRLIQLGPEKHDLRLIDTLSQPCGDLEYATLSYCWGTSRPFVTTKDNIGTLLQSIPATSLPQTFHDAIDIIWELGLRYIWIDSLCIVQDDLQDWQREATSMKDVYAGSSITISASDAQDSAQGCFVDNSLDLWDGRDIGLHQMGARFPNNREFSIRFHQGDIRRRTKFSNLNTRGWTLQEQLLSRRVIHCMQPEIHWSCHCSYRTESQVSFEGDRFKGFSWRFMPEVATEEEMKKLWLEWMTDYSSRKLTVTRDRLGALAGMVQYFGNKVGFTHLLGCWHETLVDDLLWIRRGDTVHPSMALSQVPSWSWLTRVGTIDFRFWTRSMGKYPSIIRDHVKIVEAGITWAGEPMVSDIVSSTMIVEGPVREMRLRLDHRTKNFNPPFMNVGDEEPDFSETPLPWRCPGRFDLEDEREDDMFTCLLVRSVSPESRDSLAYPYQETFLLLVPVSTSEGTAYNRVGLAMIRGDQSEFASAETKKIRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SEV9</accession>
    <name>A0A0E0SEV9_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Aprataxin-like protein</fullName>
            <ecNumber evidence="4">3.6.1.71</ecNumber>
            <ecNumber evidence="3">3.6.1.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Hit family protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">FG07145.1</name>
        <name evidence="22" type="ORF">FGRAMPH1_01T24069</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="23">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="24">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="23">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="22 24" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="22">PH-1</strain>
        </source>
    </reference>
    <reference evidence="23" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O = a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:52140"/>
            <dbReference type="Rhea" id="RHEA-COMP:13186"/>
            <dbReference type="Rhea" id="RHEA-COMP:13187"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:136419"/>
            <dbReference type="ChEBI" id="CHEBI:136420"/>
            <dbReference type="EC" id="3.6.1.72"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end adenosine-5'-diphospho-5'-2'-deoxyribonucleoside-DNA + H2O = a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:52128"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:13181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:136413"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA + H2O = a 5'-end 5'-phospho-ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:52132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13182"/>
            <dbReference type="Rhea" id="RHEA-COMP:13183"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136414"/>
            <dbReference type="ChEBI" id="CHEBI:136415"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.71"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.1.71" evidence="4"/>
    <dbReference type="EC" id="3.6.1.72" evidence="3"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SEV9"/>
    <dbReference type="FunCoup" id="A0A0E0SEV9">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A0E0SEV9"/>
    <dbReference type="EnsemblFungi" id="CEF84972">
        <property type="protein sequence ID" value="CEF84972"/>
        <property type="gene ID" value="FGRRES_15029"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24069"/>
    <dbReference type="InParanoid" id="A0A0E0SEV9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033699">
        <property type="term" value="F:DNA 5'-adenosine monophosphate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120108">
        <property type="term" value="F:DNA-3'-diphospho-5'-guanosine diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990165">
        <property type="term" value="F:single-strand break-containing DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000017">
        <property type="entry name" value="Aprataxin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032566">
        <property type="entry name" value="Znf-C2HE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF4">
        <property type="entry name" value="APRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16278">
        <property type="entry name" value="zf-C2HE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HIT" evidence="21">
        <location>
            <begin position="65"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="19">
        <location>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
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                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <property type="gene ID" value="FGRRES_20348"/>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF85386"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
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                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
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                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="CEF87987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="71" mass="7566" checksum="877AA72E5AECDC43" modified="2016-04-13" version="1">MAIAARHKTALRDYADAIGALSLGTHAAASIFISQHGGTSRVLAESQVCISNSHILNYASLLRMSIAYKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJI6</accession>
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        <submittedName>
            <fullName evidence="6">Chromosome 1, complete genome</fullName>
        </submittedName>
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        <name evidence="6" type="ORF">FGRAMPH1_01T07227</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1C3YJI6">
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07227"/>
    <dbReference type="eggNOG" id="KOG3280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJI6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_bL17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
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        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SCB64550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="222" mass="25152" checksum="3FE41465090F1036" modified="2016-11-02" version="1">MAGGTVKYRHLSRNSAARMALLRGLVTQLVHHEQIHTTYAKAKEAQRMAEKLITLAKRDNEPSRRSAQGILYRPDIHLPKLLGELKSRYLTREGGYTRVVRTESKNTYDQGESAILELVDGPKDSRFMMTAKTVARDRMLGKDHTPVTRTNIKKVTQFRGEEPFEEMVRRFMVLKASDATIPQKDESSLAEVEAEQTADQNAERAREMAAGIVPESVKRKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YK04</accession>
    <name>A0A1C3YK04_GIBZE</name>
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            <fullName evidence="3">Chromosome 3, complete genome</fullName>
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    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YK04"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19603"/>
    <dbReference type="eggNOG" id="ENOG502R8KF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YK04"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008687565" evidence="2">
        <location>
            <begin position="19"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB64875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="271" mass="31557" checksum="991F3FD82D1200F8" modified="2016-11-02" version="1">MPCFIGIIQFLRCRHCLLFKLGCTNNCEELCPTEKQVPLVATNYLWLCEDCHERKANVNLDDRCNEWADLMMDIPKGDAQLHSMMENAIRSREKADDVACEKSRVQCNEEIQWVAEWTLEYGLMIYDVLFKQMWEPQRAAERIQQLRGLRVWDLLVVKDALRGPKVLFEEQWNETYWFISDQFAEQHLLRKQQQKPPARKRPPVPLFPWKENEDKRQSRESSMSSQGLDSDGDVTLTDVQDEPVHTKHDSATSSSPIKGDGHLVTDDTAMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YK11</accession>
    <name>A0A1C3YK11_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FGRAMPH1_01T19763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YK11"/>
    <dbReference type="FunCoup" id="A0A1C3YK11">
        <property type="interactions" value="799"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YK11"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19763"/>
    <dbReference type="eggNOG" id="KOG1641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YK11"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SCB64888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="113" mass="12040" checksum="4F5073C730743575" modified="2016-11-02" version="1">MTGANIVALQATSIKSIRALAPLLDRVLVQRIKAETKTASGIFLPESSVEKLNEAKVLAVGPGALDKKGNRLPMGVTVGDRVLIPQFGGSPVKAGEEEFQLFRDSEILAKINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKS0</accession>
    <name>A0A1C3YKS0_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FGRAMPH1_01T23479</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1C3YKS0">
        <property type="interactions" value="861"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YKS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23479"/>
    <dbReference type="eggNOG" id="KOG1870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YKS0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUSP" evidence="10">
        <location>
            <begin position="246"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="594"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="135"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="552"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1072"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1419"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1461"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1521"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1093"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1142"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1423"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1475"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1597"/>
            <end position="1618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SCB65139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1618" mass="178368" checksum="AB897D8EC0E1AD58" modified="2016-11-02" version="1">MAIKDMVVTRTLATNGRYFPRLLSPSVTVKGRDQDKDEDEDAPSFPSAPLAPTPRAARAARLQDVVLKEEKALAKGRALDDDPAFSFSASVADTQPASSLPPRLQNQNSYFASADYASSAASSPCASAYADLSIESDRGGDETGSARTLARSQSPLRLSHRAIMNGDADLPQRSSSPLKRRASSMDPENEADRTRDVDMGSSQVNESVEGPSQPSSAATLPRAMSVDVPEPAAPSADDTSLSQPVPSLQEQIKIIETLLKAFRDSQPKEGDKAYLVSNAWVEKALALRGDLKDTHENDSASNPLGPVDNSDIIEEIVTEPTGNEFIRLKQGTNENEFTLFPEDAWKMVVEWYGVKDGQNAIVRTAINTAEHGDVPVIQFEFHPPVFTVHRLWSTLSPLPIEQSLKARNPPPYKFARSRKYHAQTFIKELKTATGVPMDQKIRLFTVPEVQQIAGPSEPSRALTPPDSPGRGESSGESADSWSKLLLDIASFERVRDTKTQCTLDDKTIQPNFNGGSSLSLFNLVTDQTLVIDEAIEKVSWVSTYTGKSPPNGLAIPTRSGMASSNVSGRSSPAPGGVLTRGRMGKKSGRSIGVVGLQNLGNTCYMNSALQCVRSVEELTKYFLTDEFVDEVNKTNPLGYNGKVATTYGHLLKEIYSENRGSVTPRDFKNTIGRCRSTFSGYGQQDSQEFLGFLLDALQEDLSRVKKKPYIEKPDSTDDMINNPEAIKEMADKVWDITRCRDDSVIADLFTGLYKSTLKCPECGKISITFDPFNNLTLPIPVEDVWTAKIKFLPLNDAPVMIEVELPKHSAIEQLKQFISIRTGIPPERLIGGEEYKDRFFKIYENTNDVSEEINKSDVATFHELDATPTNWPHKTKKPRSMLDVDTPLETENWDDSRYEQMVVPVFHRISSTYGRGREGVAPPSFICFTKEEASDIDLIRRKVLEKVATFSTWSKLRDVTEETSDNADGEVVISVSDADSSGDSKVIATSVESEDDIVDVHMKDDSDPLPHQPQILKRFNTTRPKFAKPDSFLDPELENLFELCYFTDKSCTGHVPTGWSHVDHHQLLPKLADRIPQSTPEGEDTGSRDDESSTPSINEDASSTDESMKAEVTQTRMAEESSEEDAQKAPRKFNGRPSKMGPHGRRGKMKGQKYGKKANNKRRERIQNKKNKAASVKPQPQPPAVADGGPLIRLGEGLVVDWNDEAWEKAFGGSSKTSEEQGAPTYLTLETLNDTALKIVQRRRKHRRTQGITLDECLDEFERAEVLSEQDMWYCPRCKEHRRASKKFDLWKSPDILVAHLKRFSSSGYRRDKLDVMVDFPIEGLDLTSRVIQKEDGKDEIYDLIAVDDHYGGLGGGHYTAYAKNFVDGRWYNYNDSSASPVSDPASCITSAAYLLFYRRRSSTPLGGSRFGVISEKYRNSEENSEVEDAEAGEGQRLGEGSSLVGLSSVGIAAAATRLPTGGSDRVTVTSYPGPDDDEDELPPYGGAEDEGVDVKEGYQQLDNRQSMNLTQTWDFTGLVDSGAEDSTGADIGSDDVQLDSSADERGFSQSDEPDMAMTGHDLMDVDRVTPASHTLPDIDNATGDHKAVIDVPTAGSDRDSSEVAEIHLENEKGTKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKY6</accession>
    <name>A0A1C3YKY6_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FGRAMPH1_01T22823</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKY6"/>
    <dbReference type="FunCoup" id="A0A1C3YKY6">
        <property type="interactions" value="741"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YKY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22823"/>
    <dbReference type="eggNOG" id="KOG1758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YKY6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048938">
        <property type="entry name" value="ATPD_C_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21334">
        <property type="entry name" value="ATPD_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="32"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase subunit delta C-terminal" evidence="15">
        <location>
            <begin position="118"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SCB65088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="161" mass="17287" checksum="61F067A02D6877A1" modified="2016-11-02" version="1">MNSFRIARAALRARPAAVRVPLQRRTYAEAIKLSLALPHQSIYKSHDVVQVNIPAESGEMGVLANHVPSIEQLKPGLVEVVEESAGSKQFFLSGGFATVQPNSVLSINAVEGYPLEDFSAEAIRAQIAEAQKVANGSGSEQDIAEAKIELEVLETLSAHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLE5</accession>
    <name>A0A1C3YLE5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FGRAMPH1_01T26155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YLE5"/>
    <dbReference type="FunCoup" id="A0A1C3YLE5">
        <property type="interactions" value="654"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YLE5"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26155"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YLE5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000145">
        <property type="entry name" value="Putative RNP domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000232">
        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000280">
        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="103"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="226"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="389"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SCB65357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="489" mass="52098" checksum="DE320F2DCE4CB480" modified="2016-11-02" version="1">MAPALALRPANNLQRERSRSPRRRSRSPERPHRRRSYSPRSRSGSRDDYRRNRDRSPMTSTGAPGGGPSAGYGGQAPHRSYEERAVAREQMMNNIRESSQQDRRVYVGNLSYDVKWHHLKDFMRQAGEVLFADVLLLPNGMSKGCGIVEYATREQAQAAVAQLSNQNLMGRLVYVREDREAEPRFIGATGGNRGGFGGGGGGMPGHFNPAYGGGAPGGGAPGGGGRQIYVANLPFNVGWQDLKDLFRQAARTGAVIRADVHIGPDGRPKGSGIVVFESPDDARNAIGQFNGYDWQGRVIEVREDRYAGSGPGMGFGGRGGFGGGMRGGFGGGFAGRGGFGGGRGGFGGGFGRGGFGGGAPGGPGFEPPASSVPPNPFTDYATAGSDRGEIIYVRNLPWSTSNDDLVELFTTIGKVEQAEIQYEPSGRSRGTGVVRFDSAETAETAITKFQGYQYGGRPLNLSFVKYLNQGGNDVMDTDPHGGLTQDQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMI2</accession>
    <name>A0A1C3YMI2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T11557</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YMI2"/>
    <dbReference type="STRING" id="229533.A0A1C3YMI2"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11557"/>
    <dbReference type="InParanoid" id="A0A1C3YMI2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF7">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="8"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SCB65720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="448" mass="49487" checksum="D3CADDFE42DCF69C" modified="2016-11-02" version="1">MTDTKIYDVVVVGGGPVGLAAGYEVAKAGASVVILEQNNFFNQAGSSGDLARMFRTMYTEEFMAELATKAMKHWDALEKDAGVSLRWMGGLLNFGDKDMGGTLLGPIDNLKKFDMHYKELSADDIEDQYPFKNLKKDWMGLFAPDNGVINVQLLLRTLYSLARDYGADAKQHTEVKQIRPSDKNKSIWEVHGTVHGKSVTYLTKKIIITSGSYVNHVLKPSFGISLGLEIWEMVATYFNTNAGPNGTIFPSMWFQFAPSVNNRSRLFYGFPTLPWGPPNVVRIAVDAATRTIKDPSERQTHILSAEDVKDTQDFVRDHVVGVDHTVPASTVSCLQTNVFDNMFVLDFLPKKYLNGGAENSIAIFTAGWAMKFVPTLGKALSEMVLKGDSDYKLKEFSITRPAPTGKEIIQENCESAGEVKMASMSIQQPGFEQAQASSYGKRDLARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMP7</accession>
    <name>A0A1C3YMP7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T12075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YMP7"/>
    <dbReference type="STRING" id="229533.A0A1C3YMP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12075"/>
    <dbReference type="eggNOG" id="ENOG502RZ2M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YMP7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3110.10">
        <property type="entry name" value="protoporphyrinogen ix oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.20">
        <property type="entry name" value="Protoporphyrinogen oxidase, mitochondrial, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF42">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB65749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="491" mass="54580" checksum="CD6DFDC5BB0ECAE2" modified="2016-11-02" version="1">MEASNSTPHRHDDYAKSRCAIIGSGLAGLVTSYLLQGDDRYNVTVFEQADRLSFDSASVTVKNDTTNDAERIDLPMRASAGGYYHHLMRMYQHLKIPLHPIKFLFVFAKATTTADGTVSHKGSDNESYFIHASNLHQTPPPWPGNRGLIAHITEILYLIVCQFWFTIACFLVAPLNATTSPTGYGESLSEYFDRIRLPRRYISHYLLPLLSGVATCTHEEMLQFPASDVVNYKKLSHGQQHYTVCGGVSQVQSRLTKGLHDIRLNCRVVEAVPQPDGTVVVRWQSTTDPSGHILEQVFDRVVLSVSPDVAGRIFKPLRSTLERFPTRQVESSVLKPEATGIHVVKNDEVRQAFACMHHSRDPSAAQTMTLRTQFPDTGSPRTEALHTMPSGVVVSTCPLREAAQPDAIKKARFTRTLRSVESQALVQKLMGGTSVDKKQADYDDHKAGWVNGQDNVWVTGAWCWDGMVLLEGCVIASMRVALDFGVAIPWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMW3</accession>
    <name>A0A1C3YMW3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FGRAMPH1_01T13593</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YMW3"/>
    <dbReference type="STRING" id="229533.A0A1C3YMW3"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13593"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YMW3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008687605" evidence="5">
        <location>
            <begin position="24"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SCB65846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="297" mass="33864" checksum="1F1CCCD33A7B5045" modified="2016-11-02" version="1">MSDQILYVTVLVGLLLLYRLANSTDKPKIKGIPEIPGVPLFGNLFQLGTDHARVARKWVAKYGPVFQTRLGNKRVVYVNSYDAVKHFWITHQSALISRPMFHTFHSVVSTSQGFTIGTSPWDESCKARRKAAATALNRPATQSYMPILDLESFVSIKELFDDCEKGTKDLDPSPYFARFALNTSLTLNYGYRINGDVNSELLHEITHVEREISNFRSTSNNWQDYVPLLRLWGAQNSSAGEFRARRDKYLTDMLNHLKSRIAEGTDKPCITGNILKDPEAKLNEGKKTLFFLFRFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMW5</accession>
    <name>A0A1C3YMW5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T13461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YMW5"/>
    <dbReference type="STRING" id="229533.A0A1C3YMW5"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13461"/>
    <dbReference type="eggNOG" id="ENOG502T2R8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YMW5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB65842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="392" mass="43443" checksum="9BD480A3F0674E25" modified="2016-11-02" version="1">MAISTPVSASFDPFDSYPTTRLPRVHVQRLIQHFLSNISFQYYPLDLNMASNPFIVSWWPLALADPALFHVSIQTASLDEERRAQRGFPVSELLMADSVSLIRNKIGSGLLAIQDETLNSVVTLAAIEHGKGNIDASRAHIDGAKRIVGIRGGLDQVKQASPLTARMIAWVSLLVTGSPQYPTQNENGMGDGVSPTLQWLLSSSFLDTPDPVVQALDLQPEIAEVFTRLRGILHQPDAPSLLGTELHDLTCFIVHKLLLMPSYTASPHSECLRCAMALYMLIIHGTTYYTHTELANNIVQLLKDHLQPLAGKTGSISFNSLQIWVLSVAIVSATDPTEIQWLTYAARIASNALGLQTWDHVVIHLKNILWLETERAEVFRHQWTSIFDVNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YN74</accession>
    <name>A0A1C3YN74_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FGRAMPH1_01T14345</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YN74"/>
    <dbReference type="STRING" id="229533.A0A1C3YN74"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14345"/>
    <dbReference type="eggNOG" id="KOG0670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YN74"/>
    <dbReference type="PHI-base" id="PHI:1206"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14135">
        <property type="entry name" value="STKc_PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044092">
        <property type="entry name" value="STKc_PRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="477"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="282"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="67"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="157"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
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            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
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        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
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            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SCB65893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="807" mass="91099" checksum="0B2D3FD1E90E5FCA" modified="2016-11-02" version="1">MTASSDEGEIVENCAEDLKATSLQHTGGSSVDRQNRQKDRLSTPDHDTASRYSNGSRRSISPRGYKRPHDDRGRDRDYHNPRSRDQDHRNSRHNYEDHRRDDPRKSRGQYDDVDRPAPRTSNYGYAGRDRDNHRDGDRDRYSNKRPRNRSRSPQRSRRADRGRFDRFVKEGQYDHRDDEPRGLKYDDSSRDGDSMSKRTTVGEASRARGHDAKPEQGLTNGHGPSKTSQRQPERKPEPEPEPDYEEPEPIDEEAEIERRRKRREEILAKSSSATPLLLHAVGAAARAASPASTLPDTPAKTRSEVESPRTPRSDIASPRSPASHVEMSPGGINLFDDNQLMNSHGKVQENEEDGPSAADYDPTGDMKEDERRDELRHGHVVLHGEQHPIATEPQPQGKDQEKPAENADGEDDDDDFDMFADDFDEEKYATKPVEPVAPIDGDGKAPDMPTIKGGILEGDDKDGYYKIRIGEVLNGRYQIQAALGRGMFSGVARAVDITTKQIVAIKMMRNNDALRKGGYTEIAILEKLNEADPEGRKHIIKFEHSFDYKGHLCMVFENLSMNLREVLKKFGNNVGINLGATRAYAYQIFVALAHMRKCSIIHADLKPDNILVNESRNVLKICDLGTAIDKTDAATAHMDVTPYLVSRFYRAPEIILGIPYDYAVDMWSIGCTLYEMYTGKILFAGDSNNQMLKAIMEIRGRFTPKLFKRGQLAPIHFDDKGQFVSVERDKVLDKTTIKTLAVVKPTRDLRTRLMAASAGMNDAETKDLNHFIDLLEHCLALNPDKRITPADALRHPFFALKAGPIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>I1R9N1</accession>
    <accession>A0A098D0W6</accession>
    <name>I1R9N1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG00182.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T00499</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315798.1">
        <property type="nucleotide sequence ID" value="XM_011317496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1R9N1"/>
    <dbReference type="STRING" id="229533.I1R9N1"/>
    <dbReference type="EnsemblFungi" id="CEF72050">
        <property type="protein sequence ID" value="CEF72050"/>
        <property type="gene ID" value="FGRRES_00182"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00182"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00499"/>
    <dbReference type="eggNOG" id="KOG1464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028981_0_1_1"/>
    <dbReference type="InParanoid" id="I1R9N1"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000006">
        <property type="entry name" value="COP9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="10">
        <location>
            <begin position="252"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF72050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="491" mass="56032" checksum="B5FD8E8F0C8FFEF4" modified="2012-06-13" version="1">MSDDEDFMQESDEEQYDFEYEEDDDEETGDVDIENKYYNAKQLKLSDPEDAISEFLGIPPLEDEKGEWGFKGIKQAIKLEFKLGQYDKAAEHYAELLTYVKSAVTRNYSEKSINNMLDYIEKGADGPEAVKCMEQFYSLTLQSFQSTNNERLWLKTNIKLAKLLLDRKEYTAVSKKLRELHKTCQREDGSDDPSKGTYSLEIYALEIQMFAETKNNKQLKALYQRALKVKSAVPHPRIMGIIRECGGKMHMSEENWKEAQSDFFESFRNYDEAGSLQRIQVLKYLLLTTMLMKSDINPFDSQETKPYKTDPRISAMTDLVDAYQRDDVHMYEKVLQRNQDILDDSFIAENIDEVTRNMRTKGVVKLIAPYTRMKLSWIAKQLKISEPEVQDILGFLIIDGKINGRINQQEGLLEITSDADAERIAALQGLTSSISELFGAVFRDGDGFRNIEHSAADEQNIEGGLLLGKVGRPGGQHRGKKGKIAAAAAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1R9X2</accession>
    <name>I1R9X2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG00286.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T00771</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315933.1">
        <property type="nucleotide sequence ID" value="XM_011317631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1R9X2"/>
    <dbReference type="FunCoup" id="I1R9X2">
        <property type="interactions" value="1277"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1R9X2"/>
    <dbReference type="EnsemblFungi" id="CEF72188">
        <property type="protein sequence ID" value="CEF72188"/>
        <property type="gene ID" value="FGRRES_00286"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00286"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00771"/>
    <dbReference type="eggNOG" id="KOG1670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043552_2_2_1"/>
    <dbReference type="InParanoid" id="I1R9X2"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000004">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
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    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
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        </location>
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        <location>
            <begin position="235"/>
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        </location>
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        </location>
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        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF72188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="255" mass="28567" checksum="7D8D157303DAA8E4" modified="2012-06-13" version="1">MAAVATEAPKMDEQVDLTTIPVDPAGKEDSSDVKDDKPVTVFHDKDNFNVKHPLQNKWTLWFTKPPSGKGDNWNDLLKEVITFDSVEEFWGVYNNVAPVSELSLKSDYHLFKEGVRPEWEDPQNKHGGKWSYQYKDKRNIDIDRLWLQVMMGAIGETLENEDDGEVMGVVVNVRKAFFRIGVWTRTIGKSIPGRGEGDVAGGKGRSGEKGKEILLSIGRRFKEVLELPASEQVEFSGHTDSAHSGSTRAKAKHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1RA96</accession>
    <name>I1RA96_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="3" type="primary">FG00423.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T01101</name>
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    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316089.1">
        <property type="nucleotide sequence ID" value="XM_011317787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RA96"/>
    <dbReference type="STRING" id="229533.I1RA96"/>
    <dbReference type="EnsemblFungi" id="CEF72352">
        <property type="protein sequence ID" value="CEF72352"/>
        <property type="gene ID" value="FGRRES_00423"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00423"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01101"/>
    <dbReference type="eggNOG" id="KOG4306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024117_2_0_1"/>
    <dbReference type="InParanoid" id="I1RA96"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08586">
        <property type="entry name" value="PI-PLCc_BcPLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="144"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF72352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="464" mass="52280" checksum="720F2DD0CA72752E" modified="2012-06-13" version="1">MANLTIRNLTINPIELIDVQRFESQRVKTGGVLSNITGFIYSSNKTHAKGDAIIKEEASVSIDPFKTEDTGIRAADSNKEAVRLTFKYENHKYEVDIPSSSNKSSVMKNLDGGNHDLTVVYTPNGAFLAIFSSAQLHRWMEELHDDWPLPLLSIPGTHNSPTCFTALPSVRCQAVDIPEQLRNGVRFLDIRVSVSSSSDDLALVHSVFPIALTGTRYFRDMVEEIYKFLDENPSETIIMSVKREGTGRGTDEQLGKYLKHSYVDKRRSRWWTEPKVPTLGSARGRIVIVRRFYLDDEMKESCWDGRGWGIDAGDWPDNCEDGQVGEGAHIRVQDFYTVTESQNIQKKIEFCRRQLERAAEQTFALAGMADHKEDADLPPFIVNFLTASNFFNATCWPERIAAKVNPSVIEYLCMCHGEEGKGPNKLKIGSAATGIVVTDWVGHRDDWDLIRCIVGMNARLQLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RAQ8</accession>
    <accession>A0A098D282</accession>
    <name>I1RAQ8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG00593.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T01509</name>
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    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
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                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
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                <person name="Rep M."/>
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            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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            <dbReference type="PROSITE" id="PS50850"/>
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            <dbReference type="EnsemblFungi" id="CEF72555"/>
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        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I1RAW9</accession>
    <name>I1RAW9_GIBZE</name>
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        <submittedName>
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        <name evidence="8" type="primary">FG00663.1</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
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    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="FGRRES_00663"/>
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    <dbReference type="eggNOG" id="ENOG502QT50">
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="6">
        <location>
            <begin position="88"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF72637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="232" mass="26224" checksum="68392881A8DC50DB" modified="2012-06-13" version="1">MKILTKEEEEAHYSAVLKGGFIGGSLGLTVGLGGVFLASRRYPAFRGLTLPFRTFLVTSAGTFGAIINADRWSMDFQKKQNPMNFYEDQTQRAQQIVRENQTAMERFMEYGKENRYSIVFVSWLASMGVAFAMVSRSPMNTANKVVQARVYAQGLTLAVLIISAIFEVNDAKKGEGRWQTVMVVDPNDPEHKRLIEKKIHKEEYEGQDLWKDMVAAEERRLAEKKQAQGSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I1RBE7</accession>
    <name>I1RBE7_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Histidine biosynthesis trifunctional protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-AMP cyclohydrolase</fullName>
                <ecNumber evidence="19">3.5.4.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-ATP pyrophosphohydrolase</fullName>
                <ecNumber evidence="19">3.6.1.31</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Histidinol dehydrogenase</fullName>
                <shortName evidence="19">HDH</shortName>
                <ecNumber evidence="19">1.1.1.23</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="23" type="primary">FG00865.1</name>
        <name evidence="22" type="ORF">FGRAMPH1_01T02171</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="23">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="24">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="23">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="22 24" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="22">PH-1</strain>
        </source>
    </reference>
    <reference evidence="23" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 19">In the C-terminal section; belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="19"/>
    <dbReference type="EC" id="3.6.1.31" evidence="19"/>
    <dbReference type="EC" id="1.1.1.23" evidence="19"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316592.1">
        <property type="nucleotide sequence ID" value="XM_011318290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RBE7"/>
    <dbReference type="FunCoup" id="I1RBE7">
        <property type="interactions" value="356"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RBE7"/>
    <dbReference type="EnsemblFungi" id="CEF72885">
        <property type="protein sequence ID" value="CEF72885"/>
        <property type="gene ID" value="FGRRES_00865"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00865"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02171"/>
    <dbReference type="eggNOG" id="KOG2697">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006732_0_0_1"/>
    <dbReference type="InParanoid" id="I1RBE7"/>
    <dbReference type="OrthoDB" id="1703565at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11546">
        <property type="entry name" value="NTP-PPase_His4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1080:FF:000002">
        <property type="entry name" value="Histidine biosynthesis bifunctional protein HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1300:FF:000001">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.810:FF:000002">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000050">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000001">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1080">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="entry name" value="Phosphoribosyl-AMP cyclohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016298">
        <property type="entry name" value="Histidine_synth_trifunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256:SF2">
        <property type="entry name" value="HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE HDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001257">
        <property type="entry name" value="His_trifunctional"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="HisI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16 19" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 19" id="KW-0520">NAD</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphoribosyl-AMP cyclohydrolase" evidence="21">
        <location>
            <begin position="213"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="379"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CEF72885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="854" mass="92316" checksum="91DF0A857D04E4AA" modified="2012-06-13" version="1">METTLPLPFLVSVASANDQPTNDGLNRQEIALLGAPFYETSSKDWGRPSAGTNVHMDATGLSDPDDVVALLDSGVRTVFVISESYSEYEQYGARVIPAVSSLILSSATEHGLLVKDFDVSSSDVDKFIEVAQSKQIKSLYVKPTPETDIEKFIEVAKKANAIPIIPSTRLTTDKNDSSRLLLSKLIASYWKSDRTDGLIPTVVTDDAGIALGLAYTSEESILEALRTQTGVYQSRKRGLWVKGLTSGDTQELLRIGLDCDNDTIKFVVNQKGRFCHLQQFGCFGDLNGISALEQTLKSRKESAPEGSYTARLFSDEKLLRAKIMEEAEELCDGKTKENIAFEAADLIYFALTKAVGAGVSLADIEANLDAKSLKVKRRTGNAKGKWAEKEGIKTEETPAKAPQPEAEKPADGRIAMERVDSTKISQADLVEKLKRPSQKSPDAILKIIKPIIEEVRTGGDKAVLSYTHKFEKATSLTSPVLKAPFPKELMDISPETIEAIDISFENIKKFHSAQQEEKSLQVETMPGIVCSRFSRPIERVGLYIPGGTAVLPSTALMLGVPAMVAGCQKIVFASPPRSDGRITPEIVYVAHKVGAESIVLAGGAQAVAALAYGTESVTKVDKILGPGNQFVTAAKMHVSNDTNAGVGIDMPAGPSEVLVVADKDANPAFVASDLLSQAEHGVDSQVILIAVDLSEQELQAIEDEVHNQAVALPRVDIVRGSIAHSVTVQVKDITDAMRISNDYAPEHLILQIKDAEKAVDQVMNAGSVFIGHWTPESVGDYSAGVNHSLPTYGFAKQYSGVNLGSFQKHITSSNLTADGLKNVGTAVMQLAKVEELEAHRRAVEIRLNYLKQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I1RDM7</accession>
    <accession>A0A098D7J5</accession>
    <name>I1RDM7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG01737.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T04229</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317572.1">
        <property type="nucleotide sequence ID" value="XM_011319270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RDM7"/>
    <dbReference type="STRING" id="229533.I1RDM7"/>
    <dbReference type="ESTHER" id="gibze-q4im21">
        <property type="family name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF73921">
        <property type="protein sequence ID" value="CEF73921"/>
        <property type="gene ID" value="FGRRES_01737"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01737"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04229"/>
    <dbReference type="eggNOG" id="KOG2565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019414_0_2_1"/>
    <dbReference type="InParanoid" id="I1RDM7"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF73921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="403" mass="45881" checksum="345648D5837B2359" modified="2012-06-13" version="1">MTVDIKPYTINVSDSEIELLKTKLEHARFPFEGEVSDDWTYGASLSDVKRLAVYWKDGFDWRAQEAKLNQYPQFTTSVSVDGFGDLDIHFLHQKSSKPDSIPLLFVHGWPGSFVEVLKILPLLTEPKDRPSFHIVAPSLPNHVFSDGVSKSGFGIPRYAETLHKLMIKLGYDKYVTQGGDWGYIITRLIGSQYPEHCLASHMSMIPAVSPPNPLKTPWQFLRFWLSPFTPLEKQGIEQMKHFYNEGLAYNLIMSSKPSTIGFGLADSPVALLSWTYEKLHDWTDGYKWTDDEILTWVSLYQFSKAGPAASCRIYYESRHADQGLTKKINDWVPNVPLGLSYFPKDIVFVPRTWGRTLGPIAFERIHTSGGHFASIERPEELVEDLRVMFSESGLGKQVVEKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I1RG89</accession>
    <name>I1RG89_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG02745.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T06593</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318710.1">
        <property type="nucleotide sequence ID" value="XM_011320408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RG89"/>
    <dbReference type="EnsemblFungi" id="CEF75102">
        <property type="protein sequence ID" value="CEF75102"/>
        <property type="gene ID" value="FGRRES_02745"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02745"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06593"/>
    <dbReference type="HOGENOM" id="CLU_847437_0_0_1"/>
    <dbReference type="InParanoid" id="I1RG89"/>
    <dbReference type="OrthoDB" id="10296386at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF75102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="328" mass="38108" checksum="72C265D1A279652D" modified="2012-06-13" version="1">MEYPAQLVHVPMPGLYETFLERYIMSMLRNPYPTASRFFSRHELYELNTKHLTVLNIEVYNDHTYHLHALVPFWPLFSHLTALQLFILRFHAVCDAMPPILHPGRLFYEDAYEIPIGLFKDLAKEDIRLQEGELTGFPYEIDEDPWECLKSKIDIVPTDSDGEYLSPTSVRRLELLFINPGIKNRPKNLYQYKLREFNQSRSPLEIYRCRKELLERFGLIKPKEQAFAAGKVAIERFEPSFSRFSQPILETPDTSTLRLTPGAQHALVTSDVDAPSVSTSMESQGARRSCWNLVLELLLFWYHDFKADFMPNELEPTADDENESAGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1RI24</accession>
    <accession>A0A098DH07</accession>
    <name>I1RI24_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG03445.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T12903</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322271.1">
        <property type="nucleotide sequence ID" value="XM_011323969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RI24"/>
    <dbReference type="EnsemblFungi" id="CEF78254">
        <property type="protein sequence ID" value="CEF78254"/>
        <property type="gene ID" value="FGRRES_03445"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03445"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12903"/>
    <dbReference type="eggNOG" id="ENOG502SPD0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117282_0_0_1"/>
    <dbReference type="InParanoid" id="I1RI24"/>
    <dbReference type="OrthoDB" id="5352317at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124264" evidence="2">
        <location>
            <begin position="19"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF78254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="147" mass="15358" checksum="94BB22C041EC96E6" modified="2012-06-13" version="1">MKFTTSLFALAAATGAVAAPSAPLEAVSMMVATPMWTIESMQRTCDKPDTTCTWNFKINTGSGAATACKYVVKASKNASQANGGPVKCGTFTVTSGWSGQFGPDNGFTTLSVVSNKKQIVYPSYTDKQVSGGKVVKPDQKYAPASLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJF0</accession>
    <accession>A0A098DIW3</accession>
    <name>I1RJF0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG03966.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T14143</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_011321696.1">
        <property type="nucleotide sequence ID" value="XM_011323394.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14143"/>
    <dbReference type="eggNOG" id="KOG2513">
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        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
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        <property type="entry name" value="Anoctamin_N_fung"/>
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    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
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    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MEMBRANE STRESS RESPONSE PROTEIN (IST2), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03330)-RELATED"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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        <location>
            <begin position="586"/>
            <end position="603"/>
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    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="7">
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            <begin position="14"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="6">
        <location>
            <begin position="164"/>
            <end position="623"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="6">
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            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF20877"/>
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        <source>
            <dbReference type="EMBL" id="CEF78874.1"/>
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    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF78874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1RK21</accession>
    <name>I1RK21_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG04209.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T14741</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321417.1">
        <property type="nucleotide sequence ID" value="XM_011323115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RK21"/>
    <dbReference type="FunCoup" id="I1RK21">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF79172">
        <property type="protein sequence ID" value="CEF79172"/>
        <property type="gene ID" value="FGRRES_04209"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04209"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14741"/>
    <dbReference type="eggNOG" id="ENOG502RCZR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065853_1_0_1"/>
    <dbReference type="InParanoid" id="I1RK21"/>
    <dbReference type="OrthoDB" id="2101473at2759"/>
    <dbReference type="PHI-base" id="PHI:1559"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802:SF1">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010372">
        <property type="entry name" value="PaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF79172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="256" mass="28611" checksum="ED967527CD94E84B" modified="2012-06-13" version="1">MYIKGPHAEPELPVLRKLIQDNPLGLITTAIPSPNYPFLQSSHIPFVLDIDDEEDETKLGKLRGHLARVNPQSKAMIENLTENPHLNNIIEQDVIVIFNSPIQHYVTPKFYTETKPTTGKVVPTWNYAAAQVYGRARIFYDTKTDEAGQFLSKQISDLSRHAETSVMGFTGGDNPVDWKVSDAPDRFVELLKKSIIGIEIEITSMGGKFKMSQEMGMGDRQGVINGFSKLESETAKEMSKMVQVRSDLKEAKKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1RK56</accession>
    <name>I1RK56_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG04244.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T14827</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321378.1">
        <property type="nucleotide sequence ID" value="XM_011323076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RK56"/>
    <dbReference type="STRING" id="229533.I1RK56"/>
    <dbReference type="EnsemblFungi" id="CEF79215">
        <property type="protein sequence ID" value="CEF79215"/>
        <property type="gene ID" value="FGRRES_04244"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04244"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14827"/>
    <dbReference type="eggNOG" id="ENOG502S2W1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040908_3_2_1"/>
    <dbReference type="InParanoid" id="I1RK56"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000207">
        <property type="entry name" value="Glycoside hydrolase family 128 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124319" evidence="1">
        <location>
            <begin position="19"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="2">
        <location>
            <begin position="25"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF79215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="316" mass="34993" checksum="A6F3516D4183F3AA" modified="2012-06-13" version="1">MAFSKHLLPLLLVSLATATSDDKRGLCYVHNKQEPQDDKIWVQNGGDITWYYNYEDQPSPVYKDIPQEKFEFVPMMWGVGSDNSDTTFLQNVKGLINDGINITHVLGFNEPDAGNDVGGSNIKPKDAAEAWVANFEPLGEMGIKLGLPACTGGWGGMPWLRQFLGNCTEIKSRGGPKRNCTWDYLPVHWYDNFEGLASHIGERLAEWPNASIWVTEYAYAHQDPKPTDSFFKQTLKWFDESEFIGRYTYFGAFRSDVSNVGPNAVFLSSSGSLTTIGAQYLGLNTTGENSASHSKVSLPSVGCLALILAVFVKLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1RKE6</accession>
    <accession>A0A098DK61</accession>
    <name>I1RKE6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG04348.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T15075</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321262.1">
        <property type="nucleotide sequence ID" value="XM_011322960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RKE6"/>
    <dbReference type="EnsemblFungi" id="CEF79338">
        <property type="protein sequence ID" value="CEF79338"/>
        <property type="gene ID" value="FGRRES_04348"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04348"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15075"/>
    <dbReference type="HOGENOM" id="CLU_1230009_0_0_1"/>
    <dbReference type="InParanoid" id="I1RKE6"/>
    <dbReference type="OrthoDB" id="5065447at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF79338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="232" mass="27361" checksum="49DD6A20DA4B800F" modified="2012-06-13" version="1">MPNRAGRQRRPAGRQRRSAGRQRRPALRPLRPAPERAETPFEVESRYVEDPGPSPYYFVDRRMARLIRAGQREAADEQYLRDMESNPDLEEQIFDDSEVESDADPTAAQRPRGHWRIHRCDLCNSILERRYIIGSDHGDIFVSSSRCYNCLFTFSWLRATLDDESLQREYTRIILEYNENLRRRTSIANVQARWRARARGVRINSHLVRNIPLGHWAREALRREQEEDSDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>I1RKF0</accession>
    <name>I1RKF0_GIBZE</name>
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        <submittedName>
            <fullName evidence="12">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG04352.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T15085</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321258.1">
        <property type="nucleotide sequence ID" value="XM_011322956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RKF0"/>
    <dbReference type="FunCoup" id="I1RKF0">
        <property type="interactions" value="760"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RKF0"/>
    <dbReference type="EnsemblFungi" id="CEF79343">
        <property type="protein sequence ID" value="CEF79343"/>
        <property type="gene ID" value="FGRRES_04352"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04352"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15085"/>
    <dbReference type="eggNOG" id="KOG0768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_3_0_1"/>
    <dbReference type="InParanoid" id="I1RKF0"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000018">
        <property type="entry name" value="S-adenosylmethionine mitochondrial carrier protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="91"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="192"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF79343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="280" mass="29716" checksum="45FB0B96AF7999EF" modified="2012-06-13" version="1">MSADPPSFQSALLAGALAGTTVDLSLFPLDTLKTRLQSSAGFFPSGGFSGIYRGIGSALVGSAPGAAFFFCTYESVKGLLADKDNTSAPGWKAPVTHMAAASAGEIAACAVRVPTEVVKQRAQAGHHGGSSAAALRAILSKYSSHGFVPMWRELYRGWGITVFREVPFTVIQFPLWEAMKSWGRRRRDGREVTAAESALYGSMAGGFSAALTTPLDVLKTRVMLSKESVSVSRIFSQIMREEGSKAFFAGLAPRVTWISIGGAIFLGSYQWAINTMNGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1RL22</accession>
    <name>I1RL22_GIBZE</name>
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        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG04600.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T15673</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320979.1">
        <property type="nucleotide sequence ID" value="XM_011322677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RL22"/>
    <dbReference type="EnsemblFungi" id="CEF79636">
        <property type="protein sequence ID" value="CEF79636"/>
        <property type="gene ID" value="FGRRES_04600"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04600"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15673"/>
    <dbReference type="eggNOG" id="ENOG502S1RP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150802_0_0_1"/>
    <dbReference type="InParanoid" id="I1RL22"/>
    <dbReference type="OrthoDB" id="5366606at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF79636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="143" mass="15406" checksum="270840C287AC47B3" modified="2012-06-13" version="1">MAPSEFHVRLQRGITGGFAPPTPDLIINIDASNNDLRISIAKREDGSPDLAPSASNTVAIADHEAVIDELHGILKEVPTEQPPGGEDIYGLNTSIAWQSDDLEWWNGGPQGCGGGQSFVQAQDKDKEMFKRAVEIVKEIAGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RLA8</accession>
    <name>I1RLA8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="4" type="primary">FG04695.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T16087</name>
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    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323127.1">
        <property type="nucleotide sequence ID" value="XM_011324825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RLA8"/>
    <dbReference type="EnsemblFungi" id="CEF88847">
        <property type="protein sequence ID" value="CEF88847"/>
        <property type="gene ID" value="FGRRES_04695"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04695"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16087"/>
    <dbReference type="HOGENOM" id="CLU_1120256_0_0_1"/>
    <dbReference type="InParanoid" id="I1RLA8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF88847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="248" mass="28162" checksum="E46A5ABD6040F29B" modified="2012-06-13" version="1">MEDSTALITRHHVEHAQPKDRYLYSENNALPPTHDGYMDIDEAWRRFEVARRSAEFYMDQYFQNLEAGTAQPRAGPNSRSSLAPLALIGVRLGTSSPSNQLPETSDTVETRGGQLRDGRYWNRKAARDSLIRDLNEMGFWIAQLSSSQQFQVKIPICVACFSGIVMSGLQHVRSQLLQWAVYVGKIAALLAMASSLGYMIHGRRRVVEYSRHKESISQCLDAVYGWALTNGHQKVVTKKQYWLLKRLS</sequence>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1RMK0</accession>
    <accession>A0A098E4P4</accession>
    <name>I1RMK0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 3, complete genome</fullName>
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    <gene>
        <name evidence="9" type="primary">FG05190.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T17325</name>
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    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="protein sequence ID" value="CEF88148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="CEF88148"/>
        <property type="gene ID" value="FGRRES_05190"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17325"/>
    <dbReference type="eggNOG" id="ENOG502QTNB">
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="PA-PHOSPHATASE RELATED-FAMILY PROTEIN DDB_G0268928"/>
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        <property type="entry name" value="PAP2_3"/>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1RMU6</accession>
    <name>I1RMU6_GIBZE</name>
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        <name evidence="4" type="primary">FG05296.1</name>
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    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
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                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
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    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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            <end position="82"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF88478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="114" mass="14213" checksum="67749D432B1A6413" modified="2012-06-13" version="1">MGRRDTYSEPPRGRRQSRRQHPEARREHKQFQKERGFDWTPGLVLALIGAVTFFSKDFDRYKHKHEWRDEDSQDNRSRDDGRGRRRYRSSSRRPDYYEDDDDYYYDRRDRGYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I1RND7</accession>
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            <fullName evidence="5">Chromosome 3, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreales</taxon>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_011324057.1">
        <property type="nucleotide sequence ID" value="XM_011325755.1"/>
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    <dbReference type="FunCoup" id="I1RND7">
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        <property type="gene ID" value="FGRRES_05510"/>
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    <dbReference type="eggNOG" id="KOG0076">
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    <dbReference type="OrthoDB" id="414781at2759"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
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    </dbReference>
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        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RASTRNSFRMNG"/>
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    </dbReference>
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        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
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    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
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    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
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        </ligand>
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    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
            <position position="55"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
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        <ligand>
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        <location>
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        <ligand>
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        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF88780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="213" mass="24180" checksum="ED45F5D869E96A3A" modified="2012-06-13" version="1">MYHLAKGLYLYATSKEEYSVILLGLDNAGKTTFHEQVKSMFLPNRPDPKLKTVPTVGQNVSTIPLQDMYLKLWDVGGQHSLRKLWESYYTSCHAIVFIIDSTDIGDGNIEHDENLGRLEECRLVLEDVLQHTETEGVPLLILANKQDREDCVETIRIKEGLVKKVMEGDKGSAVRDSRVLALSALTGDGVREAIEWVRTRVQWNKESRPPVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RNH1</accession>
    <name>I1RNH1_GIBZE</name>
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        <submittedName>
            <fullName evidence="7">Chromosome 3, complete genome</fullName>
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    <gene>
        <name evidence="8" type="primary">FG05550.1</name>
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    <organism evidence="8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324100.1">
        <property type="nucleotide sequence ID" value="XM_011325798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RNH1"/>
    <dbReference type="FunCoup" id="I1RNH1">
        <property type="interactions" value="694"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RNH1"/>
    <dbReference type="EnsemblFungi" id="CEF87620">
        <property type="protein sequence ID" value="CEF87620"/>
        <property type="gene ID" value="FGRRES_05550"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05550"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18187"/>
    <dbReference type="eggNOG" id="KOG4183">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034953_1_0_1"/>
    <dbReference type="InParanoid" id="I1RNH1"/>
    <dbReference type="OrthoDB" id="532500at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF87620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="439" mass="48705" checksum="FF41BFD803C9DF83" modified="2012-06-13" version="1">MGSEKRKRGGDTTSKPKKKVAIDASPSTTVSSVLRPKHCPPVIATAVGFDVPKNIPFHSYAPKDAAKSKAKQAKSAGEKDFLLHSNAHRTMDYTVKADGARGVKPALNHFLGIYDPKTGKLEVVEAKKMTMRAAVRAKQSAAAAAGERDASQTMMQLKTDLGQTFGTKKAKKAIQENVLNAIAPQKKTGEAPTKIDAAARAMLSSVGEVTSTMASREELQAVVDEARPVPIPNLEATEIQDVYDPKRIIGADILKLVPVREWQEKVQHKESIQVPSRFVAARVTRVAGNEDATDRLRVLRYFFFVLLFYLHSKPGKARGTRSIPPRDKLREFLAPAPEAVVESIRRKFSERGEMRKFHIDLLITHCCVFASIIDNFEVDTQNLRDDLKIDQKTMNSYFHEIGGRVKPVTNKETKTTVSLARLALPLNFPKQRHIAPKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQA8</accession>
    <name>I1RQA8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG06249.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T19863</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324897.1">
        <property type="nucleotide sequence ID" value="XM_011326595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQA8"/>
    <dbReference type="STRING" id="229533.I1RQA8"/>
    <dbReference type="EnsemblFungi" id="CEF88483">
        <property type="protein sequence ID" value="CEF88483"/>
        <property type="gene ID" value="FGRRES_06249"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06249"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19863"/>
    <dbReference type="eggNOG" id="ENOG502RES8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142375_2_0_1"/>
    <dbReference type="InParanoid" id="I1RQA8"/>
    <dbReference type="OrthoDB" id="5239281at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF88483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="143" mass="15727" checksum="BC851D77A969A489" modified="2012-06-13" version="1">MPAKKSSGEDGSPTGLTDGELRFIKAIFDNMTQKPDADWDAVAQTLSLKDAKCAKERFRQMSVRHGWRGDSATASPRKGPAAAAGDKVTKKPRAPRTPRKPAAKKVAKKTEPEDDDEDDEDVKDEVKPESKNVKSENEDEDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQD1</accession>
    <name>I1RQD1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG06272.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T19915</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
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                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
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        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Nectriaceae</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326041.1">
        <property type="nucleotide sequence ID" value="XM_011327739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQU3"/>
    <dbReference type="ESTHER" id="gibze-q4i8l5">
        <property type="family name" value="PAF-Acetylhydrolase"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF84480">
        <property type="protein sequence ID" value="CEF84480"/>
        <property type="gene ID" value="FGRRES_06443"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06443"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22289"/>
    <dbReference type="eggNOG" id="KOG3847">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026278_0_0_1"/>
    <dbReference type="InParanoid" id="I1RQU3"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
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        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF14">
        <property type="entry name" value="PAF ACETYLHYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124442" description="1-alkyl-2-acetylglycerophosphocholine esterase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF84480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="359" mass="39047" checksum="773B60EC51703BED" modified="2012-06-13" version="1">MHLSILFLSLLGIGTAINLPDPTGPYGVALRPQGMTDTKRIDPYDPKKGHRQVLASIFWPIHSTVCSKEIVPYMPPAVAQFYGQQAQSMGLSNDTFAAFEYAVCKTPASAKGCDSQRSFPLAVFSPGAGNSRLLYSNMARSLASYGNIVVLIDHPYDADIVEFPDGQIIRSGNIPETTKSLIDLTKVRAMDISFVISKVLQPSFQRKVFKGLPGSVDSKKVFALGHSLGGASAAVASLSDVRLRGGMDLDGQIFEPALSKGLDKPFFLVGRPNHSKEDTTWKTFYAKLRGPKKEIAIKGTVHGSFTDYPQLIQALHLPASTQKAVQQLVGDIDADYLQKFLSETTVRFMNISFGSEAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQX4</accession>
    <accession>A0A098DWY9</accession>
    <name>I1RQX4_GIBZE</name>
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        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
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        <name evidence="2" type="primary">FG06475.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T22369</name>
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    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326076.1">
        <property type="nucleotide sequence ID" value="XM_011327774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQX4"/>
    <dbReference type="EnsemblFungi" id="CEF85403">
        <property type="protein sequence ID" value="CEF85403"/>
        <property type="gene ID" value="FGRRES_06475_M"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06475"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22369"/>
    <dbReference type="HOGENOM" id="CLU_1695641_0_0_1"/>
    <dbReference type="InParanoid" id="I1RQX4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF85403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="155" mass="17478" checksum="D2BE38E100C4A3AE" modified="2012-06-13" version="1">MCRENLAAIFHAQDRDDDTAHEHETVINACKQRLIYKRFGRSKLQRVCIENCLSTQGASKDLGEITIDIILSNTIEVMQLDYFPLSRRWALPCFEPHDLRIFGSGYPISLCTSDSNHSAGSLSIVSVKGNQFQITTVTGRPGDESNRHHEQRASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1RR27</accession>
    <accession>A0A098DQA2</accession>
    <name>I1RR27_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
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    <gene>
        <name evidence="4" type="primary">FG06534.1</name>
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    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326145.1">
        <property type="nucleotide sequence ID" value="XM_011327843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RR27"/>
    <dbReference type="EnsemblFungi" id="CEF84041">
        <property type="protein sequence ID" value="CEF84041"/>
        <property type="gene ID" value="FGRRES_06534"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06534"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22525"/>
    <dbReference type="eggNOG" id="ENOG502SQZ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027731_0_0_1"/>
    <dbReference type="InParanoid" id="I1RR27"/>
    <dbReference type="OrthoDB" id="5314201at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF84041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="536" mass="59930" checksum="0542640E1545A1CC" modified="2012-06-13" version="1">MHLAPRDRAEALLLKAARAHGIPATKDDIRSALSDTTFVEWANLHLATDNLLTGDELALYTALDKSGQVDRLADLHDLGEVQAVNEDDIRAAIEELNRSTETITKQTETLRQQQDALARLVKKRDEAEIERKELEDERLRKTRYTLNKLVFEVDGEAQSLEYRVQDLEQIAKTSRSNVKRTVESVFQSDDKLLLSLQKLGWELDQQDPEEEKTIEKLREICMRLIKTTVETLRTRLDRIYLEAILAAERSGDVKAATQDDVKALEEELESLYSEILPVAQMSTEQQHLEPALKSTDAQSGQSLRRSAVAVTYVNECLDHLVDKVTLLTERVKTLQSHNAAASSIIATAKAESSASLSPEKKKSIRAAMPASPIRNPSPIRMRANTVGSHRGTNNKSSRRSSGILDEPAIEALLRDLALSLPDAEEASIQDQVSALNKAFRERSDKTTDVMRGAQEGFEMGVTSRLDDARLAIQLLRDSMLAESPFGKVKMLDPEFEESVVALERDLEGVKEKLDGVVDKKALAKSVKKDEFVQRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>I1RRQ3</accession>
    <accession>A0A098DQV2</accession>
    <name>I1RRQ3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG06788.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T23191</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326439.1">
        <property type="nucleotide sequence ID" value="XM_011328137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RRQ3"/>
    <dbReference type="FunCoup" id="I1RRQ3">
        <property type="interactions" value="1067"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RRQ3"/>
    <dbReference type="EnsemblFungi" id="CEF84231">
        <property type="protein sequence ID" value="CEF84231"/>
        <property type="gene ID" value="FGRRES_06788"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06788"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23191"/>
    <dbReference type="eggNOG" id="KOG0319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009276_0_0_1"/>
    <dbReference type="InParanoid" id="I1RRQ3"/>
    <dbReference type="OrthoDB" id="5414888at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001009">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001144">
        <property type="entry name" value="WD40 repeat-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
        <property type="entry name" value="Utp13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="222"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="270"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="418"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="531"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="680"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="8">
        <location>
            <begin position="733"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF84231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="907" mass="99374" checksum="E8E6059E8582D754" modified="2012-06-13" version="1">MANKQPLKTTFDIKHVIRPIFTGGSVSIDNDARILATVLGEDVVLTDPTNGKHLAQIEGDGELISTLTLTPSGSHLIICSRSLSMRIYSLKRSEDDETIEATATRSVKAHSTPVNVLTVDRTSTLLATGGTDGAVKVWDIVGGYVTHTFRGSSVLVSSLRFFEAASRSNETQSRKGKKSKRQEESDDEEESSTTINFRLACGQQDGKVRVWDLHKRNCVANLDSHVSDVQGLDYSPEQHALVTAGRDKTITWWDAKSWKIRKVVPCLELVEAAGFIDDGNLTYSAGANGSLRIWDTDTGKEVTPQQSAKSEEEGIVSVIYRPGLPFILLVQVDHTLALYRPPQKADAASLSAPEPFRRISGTHDDIIDLGYLLPDRSMVALATNSEDVRIVSVVETQDQDDGGNSGSSPYFGQDVALLKGHDEIVISLDIDWSGHWIATGAKDNTARLWRIDPANNSYTCWAVFSGHAESLGAVALPKSVPPESSAARTDPLSHPPAFLITGSQDQTVKKWEIPRTAQQGHKNSARAIFTRKAHEKDINAINVHHSNQLFASASQDKTVKIWSAEEGEVQGILRGHKRGVWSVQFSPAQLPAIQGEDGPVTGKGVILTGSGDKTIKLWNLASYTCVRTFEGHSNSILKVAWLNMPTSQEQSKKRVHFASAGGDGLVKVWDANSGETECTLDNHEDRVWVVAVHPENNTIVSGSGDSTVTFWKDTSSETQAAASQAALKVIEQEQELENHIHAGSFREAITLALQLNHPGRLLSLFNSVMTTEKPDKGSLSGLRAVDEVLGSLSDEQIFLLLLRLRDWNTNARTAPVAQRILWTLIRSYPASKFSNLSVKGAKGQKSLKDVLHAIRVYTERHYKRTEELVDESYLVEYTLQEMDDLAPMLEDENALLQDGSEDVVMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1RSY8</accession>
    <name>I1RSY8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG07275.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T24401</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327016.1">
        <property type="nucleotide sequence ID" value="XM_011328714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RSY8"/>
    <dbReference type="STRING" id="229533.I1RSY8"/>
    <dbReference type="EnsemblFungi" id="CEF84294">
        <property type="protein sequence ID" value="CEF84294"/>
        <property type="gene ID" value="FGRRES_07275"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07275"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24401"/>
    <dbReference type="eggNOG" id="ENOG502SPQT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098340_0_0_1"/>
    <dbReference type="InParanoid" id="I1RSY8"/>
    <dbReference type="OrthoDB" id="3907216at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF84294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="241" mass="27140" checksum="AC70C9A25C6F7956" modified="2012-06-13" version="1">MNTLRPLRGGCQCGRNRYIIAVPQDGINEAQVLFNTDSAHQTSLATPLAAYIRVPLSWYHSTTYSFFPDETHALIRRVYTHPSQEHSKRHFCGYCGTPLSYWSENPQTEADFINLTLGSLLREDLRDLEDMGLIPEEEDSRNLTTQASDVVGRNTALRQSYGVPWFDGMVEGTRLGNMRRSQGVKQSQDGRVKVEWEIVEYSGNGDEPKGSPRHDIDVEMSVTGKRKMKDRDDPDAATGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I1RSY9</accession>
    <accession>A0A098DQH4</accession>
    <name>I1RSY9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG07276.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T24403</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327017.1">
        <property type="nucleotide sequence ID" value="XM_011328715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RSY9"/>
    <dbReference type="EnsemblFungi" id="CEF83123">
        <property type="protein sequence ID" value="CEF83123"/>
        <property type="gene ID" value="FGRRES_07276"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07276"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24403"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_1"/>
    <dbReference type="InParanoid" id="I1RSY9"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF83123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="284" mass="32060" checksum="0AA924CEB9F24B2D" modified="2012-06-13" version="1">MDTALTAASRLSLRNSTSIIPCIGFGSYKIRGETCAAAVLAALPAGYRHIDSAALYRNEVRVREAIEQSGVFREDLFLTTKVGSPRRKTEKTEAYEDVIEAVERIAGKDGYVDLLLMHVPGPSREHRHSLWEAMERAKREARARNIGVSNFRVRHLDEMKEYATEWPPSVNQIELHPWCQQKEVVKYCQDNEIIIEAYSPLATGARLEDPLVEGISTKHDKSHAQVLIRYSLQKGWVPLPKSSRPDRISENFNVFDFVLDEDDMETLDDLDKGSAGAIFKMNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1RT17</accession>
    <name>I1RT17_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG07307.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T24479</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327053.1">
        <property type="nucleotide sequence ID" value="XM_011328751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RT17"/>
    <dbReference type="STRING" id="229533.I1RT17"/>
    <dbReference type="EnsemblFungi" id="CEF85762">
        <property type="protein sequence ID" value="CEF85762"/>
        <property type="gene ID" value="FGRRES_07307"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07307"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24479"/>
    <dbReference type="eggNOG" id="KOG0772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014033_2_0_1"/>
    <dbReference type="InParanoid" id="I1RT17"/>
    <dbReference type="OrthoDB" id="10264376at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="95"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="207"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="476"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="552"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF85762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="578" mass="62740" checksum="E268EC983B9C8B2B" modified="2012-06-13" version="1">MSSDDDFEIEVPDLAADDPMRAFLPTSFGKKSKEADIAAQFDRSRRTVTSTAPEASGGQAQGPKKKGNSSDDSDSDDSDDSDDEDEFPVSHELVLKTHERAVTTVSLDPAGGRLATASTDCTVKLHDFASMTPTTLRAFRSVDPYEQKASSASSEAHPVHRIEFNPHAGGVFLCVSAHPQAKIMSRDGDIVTEFVKGDMYLRDMHNTKGHISEITTGTWHPTDKNLCITAGTDSTLRIWDVNNKRSQKDVIVFKSKAAGSAGRTKMTAVAWGSSAQGGSNVLVASALDGSLVMYSGNSPFSRPAGEIRDAHKPQTWTSGIDISSDGRMVVTRGGDDLIKLWDTRKFTKPLVTVSHTSTSDHYSTSNIKYAPNSTSIITGSITGHLHILNPGNLRAEHVTPITPGSPLITVDWHPKINQIITGSANAETHVLYNPQMSNKGAVDVMSRAPKKRHIDDNPELTMDQSVGVSGDAIMVPGATGGSRKAGVTVSGRSKDPRRPYMPQQTPLQKNAPDEKSIAENIPLARMLHEDPREALLKYADKAQKDPMFIKAWSKTQPETQYAELSDEEDGPDKKRLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RTF1</accession>
    <name>I1RTF1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG07454.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T24861</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a zinc transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327226.1">
        <property type="nucleotide sequence ID" value="XM_011328924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RTF1"/>
    <dbReference type="FunCoup" id="I1RTF1">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RTF1"/>
    <dbReference type="EnsemblFungi" id="CEF84132">
        <property type="protein sequence ID" value="CEF84132"/>
        <property type="gene ID" value="FGRRES_07454"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07454"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24861"/>
    <dbReference type="eggNOG" id="ENOG502QV77">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024994_1_1_1"/>
    <dbReference type="InParanoid" id="I1RTF1"/>
    <dbReference type="OrthoDB" id="5382797at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF5">
        <property type="entry name" value="ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="194"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF84132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="484" mass="52951" checksum="7D53BD14CC77D009" modified="2012-06-13" version="1">MSDYPGACPPQKLRPPSLVFQGDNGDDFDITNFETFPDGSADRDNDPFAINRQLNRHAVAQNSAAANLLIPSTTTTSSSLALPTMNAEDETADSPLSPGFKNPFNFQTQVISAGPVKSNIGQRRGHRYKHSSISSQHQIFKEPPQRPPPVLPASLPIPTVREAWKSMTKDQRIHCYWSMCHLTVATYIFFRSEGSLATTALSHLVFFDAGSAAVCVMVDVLGNFEVWRRSSIRHPFGLERAEVLAGFAMSVFLLFGGFDLVSHTLKHFLESLGNHEAHHEHGHDSPDGSIDLVSAAAMVSTLVSAYGLRNHARIAKLLRVSYLAALPSVLSNPFHFLTLSFSAVIALLPLLSISLYTWLDRLICAVIAFAMFALGMRLAVAQGLMLLMSYGGSDGNNGVSAVLREIETEPSVVTIDDAQFWQVHYGLCMANIKLSVVKGYDEMSISKLRQRISGLIQNRLGEGYGHGGSIRWEVTLQMSTDGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1RU47</accession>
    <accession>A0A098DWR5</accession>
    <name>I1RU47_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG07726.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T25497</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327530.1">
        <property type="nucleotide sequence ID" value="XM_011329228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RU47"/>
    <dbReference type="EnsemblFungi" id="CEF85792">
        <property type="protein sequence ID" value="CEF85792"/>
        <property type="gene ID" value="FGRRES_07726"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07726"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25497"/>
    <dbReference type="eggNOG" id="ENOG502QQIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012066_2_0_1"/>
    <dbReference type="InParanoid" id="I1RU47"/>
    <dbReference type="OrthoDB" id="415532at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049207">
        <property type="entry name" value="DUF4246_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21666">
        <property type="entry name" value="DUF4246_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="3">
        <location>
            <begin position="8"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="109"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF85792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="662" mass="75691" checksum="B6013FF94C2AC4A0" modified="2012-06-13" version="1">MSASPIVYPGLGLDIRHYDQDTNGEIYPMGIHSSCIGSESEILLVREVAMMIVMNELTDKPDWHVKVFDETIAEKWIEEALALPTEPLYHDIVPSEVRGKVLKVILDRKCLEFCIQELRAKAKFFEKTGLVPTLDASASVVKADGYIDDSLRQSLQAAFTKLKLEQKDDPDWHPNTNEMVQNLVHPSLYPLVYGRSRVFREEVVGVEDAIDRWSGKGEVIPKPDTSYTSQTPFLASMGGVQVDNSNWSDTYQWLPSNVSFQDDGSVKFTSYINGLHPTKHREIYATIEKLVEKALPAWDFSVPCYRDWKMVGACRTKPRFNKPETPDDEEEANWNISLDDVPKRDKMTEKDEDGDDSDDEVYSDEEEQQHHDWKKIREPIQPEAPEFKAWNYGTKPGESLRERFQDRGLQVIVKMASIELTPDKPVFPAGGWHVEGQMNEHIVGTALYYLDSENVTSSSLAFRMQTTYDQWDLQEKVGQDSYSWLEQVFGTDLSGGSCLQQYGKVETKEGRLLAFPNVFHHRVSSFKLQDEAKPGHRRFIALWLIDPHTRIINTGNVPPQQHSWWMERAFGNTENVPIPHPIATIVSEAAPDHLGIQAAVEKGRPLPNELMEMVKREAGDCVMPMSLQEAKEHRLKLMEERSRSQTKVDSNWRSETYSFCEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1RUB1</accession>
    <name>I1RUB1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG07797.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T25689</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. FUS2 hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327616.1">
        <property type="nucleotide sequence ID" value="XM_011329314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RUB1"/>
    <dbReference type="STRING" id="229533.I1RUB1"/>
    <dbReference type="EnsemblFungi" id="CEF85030">
        <property type="protein sequence ID" value="CEF85030"/>
        <property type="gene ID" value="FGRRES_07797"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07797"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25689"/>
    <dbReference type="eggNOG" id="ENOG502SIEE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034451_1_0_1"/>
    <dbReference type="InParanoid" id="I1RUB1"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.110">
        <property type="entry name" value="acylaminoacyl peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF12">
        <property type="entry name" value="CONIDIAL PIGMENT BIOSYNTHESIS PROTEIN AYG1 (AFU_ORTHOLOGUE AFUA_2G17550)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124516" evidence="2">
        <location>
            <begin position="19"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="201"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF85030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="436" mass="48392" checksum="38D3C2388D1C2F33" modified="2012-06-13" version="1">MKTILFFTFYAASGIAQAKVADNSSTKSPILHLSEDDNFNFDILTGLGQAHNDGADINPVLSVAKDIIPGDFESYSKEWFKLANLTKARALDPEIAYDPINVRATWFSIANYFRRADVYNRADWDDPRINDYWDEQTSAFNKAIAALPVPGERVDLPSTSGSFNISGIWYSQPHTNNSTKKHPTLILTQGFDAAQEDLYSSVVAPGLARGYNIFSFEGPGQPTPRREQGVGFIPDWEQAVTPAVDYVLTEKAAFVDPKKLTLYGHSFGGYLAARAAAFEPRLSALMLNGGVLDGYEAYTNFLPPKLLKILESGEKEAFDKSMDALLDDPDASTDLKWGMLQAKWAFKTKSIYEFFQMTKEYTLKGGLLDRIKIPVWLADGEYETLMAGQSKLVKDQLGDNAELHFFNGTAGFHCQTGATQELARVMFAWLDKVLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RVL4</accession>
    <accession>A0A098DDR9</accession>
    <name>I1RVL4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG08295.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T09589</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320498.1">
        <property type="nucleotide sequence ID" value="XM_011322196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RVL4"/>
    <dbReference type="EnsemblFungi" id="CEF76597">
        <property type="protein sequence ID" value="CEF76597"/>
        <property type="gene ID" value="FGRRES_08295"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08295"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09589"/>
    <dbReference type="eggNOG" id="ENOG502S6M4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053560_0_0_1"/>
    <dbReference type="InParanoid" id="I1RVL4"/>
    <dbReference type="OrthoDB" id="5217806at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="315" mass="35631" checksum="4E1D080A035C6EEA" modified="2012-06-13" version="1">MMNILDKVALAHVVMVAVGSYIPSLYLFFSSLCTVRSQKDPVRTAFTYAKYALFIFSVHAFFDIGNYSTYLIFSATYNYRDPEDEDFDWGRYASMMEALGICTPVFRMVAKLSDVVTDILIAIILLRLSTAIFTLYSGSAAGKKLRHVSYGMAFVLFALALTFFGLQIRSIFDLRYGDIDIGADCHEKGLKVELATRVLIFVISLAVFVKAVMVKKQAKADKNLTWASTMLVVASVVWLLHTSFAMASMAAWENFGSYWSAPRVEYKLYFYILEVIFRIWPQFVTLVIVYVLGRAKANGIWSKQQNSSKQDEEGK</sequence>
</entry>
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    <accession>I1RWZ7</accession>
    <accession>A0A098DH58</accession>
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        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319876.1">
        <property type="nucleotide sequence ID" value="XM_011321574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RWZ7"/>
    <dbReference type="EnsemblFungi" id="CEF77281">
        <property type="protein sequence ID" value="CEF77281"/>
        <property type="gene ID" value="FGRRES_08837"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08837"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10957"/>
    <dbReference type="HOGENOM" id="CLU_1578664_0_0_1"/>
    <dbReference type="InParanoid" id="I1RWZ7"/>
    <dbReference type="OrthoDB" id="5074008at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="169" mass="19361" checksum="41D02FEC2CB73959" modified="2012-06-13" version="1">MPPRAAGEGDGDGPSSAQTNDSLRWPGLYPEQAQIVINYLMYNEYRSERVLSGSHWDRQRLALHDAIYIHFNALERHLPGLMELCAIEIVHIALSLPILSFLCCITGYREWVHLNSRWFSPVMFHYREYAMPDAAIGDIETFRALNFIDDYSRAVELLGPLLIALQQLI</sequence>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1S0F9</accession>
    <name>I1S0F9_GIBZE</name>
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        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
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        <name evidence="5" type="primary">FG10185.1</name>
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    </gene>
    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75545.1"/>
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    <dbReference type="EnsemblFungi" id="CEF75545">
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        <property type="gene ID" value="FGRRES_10185"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10185"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07481"/>
    <dbReference type="eggNOG" id="ENOG502S3QV">
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    <dbReference type="HOGENOM" id="CLU_043818_0_0_1"/>
    <dbReference type="InParanoid" id="I1S0F9"/>
    <dbReference type="OrthoDB" id="436519at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
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        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
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        <property type="entry name" value="JDOMAIN"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1S190</accession>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="protein sequence ID" value="CEF75920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_011319477.1">
        <property type="nucleotide sequence ID" value="XM_011321175.1"/>
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    <dbReference type="AlphaFoldDB" id="I1S190"/>
    <dbReference type="STRING" id="229533.I1S190"/>
    <dbReference type="EnsemblFungi" id="CEF75920">
        <property type="protein sequence ID" value="CEF75920"/>
        <property type="gene ID" value="FGRRES_10490"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10490"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08233"/>
    <dbReference type="eggNOG" id="ENOG502SMU6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041307_1_1_1"/>
    <dbReference type="InParanoid" id="I1S190"/>
    <dbReference type="OrthoDB" id="5207033at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF75920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="437" mass="51003" checksum="F3833C1E52B6DEA0" modified="2012-06-13" version="1">MPQPSKRVHQNCKEFYVLSWDKEGLMGVGKKEWRGLKQIRPSEFYSDGLHPSLTTDSHVTVIFADADMVRECPSCRKCFTDEFLMPELWWSGYSRRSNGYFGSETFRDDEGELLALNTWSRFLVKQLVDQNTHVWHKFNIFTRWIASTQQTYLIVFESPKQTRLRGLFPEPLLTNSHSDALNDPFWVYPRLLEQLSNLQDNSVWAVRDQVRGIEKEKWSKRPSPRYRHMHDTARHAIHVSETLEVAEKTVASILQQHNVFRDEVGWGDRQRNAGFRRVDERLLWYDHILRSLRHRASANKERLLNEVQLAFNSVAQYDSRVAVKIGRATQSDSAAMKTIAFVTLAFLPGTFISALFSMSFFNVDDDTGQWTVSNKIWMYWAIAIPVTLITSGLWLLWQRCFPPAWVGEEEESANSLRDLRRKIKRGDSARVDIYQMA</sequence>
</entry>
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    <accession>I1S250</accession>
    <accession>A0A098DXW5</accession>
    <name>I1S250_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG10834.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T20587</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325559.1">
        <property type="nucleotide sequence ID" value="XM_011327257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S250"/>
    <dbReference type="STRING" id="229533.I1S250"/>
    <dbReference type="EnsemblFungi" id="CEF86172">
        <property type="protein sequence ID" value="CEF86172"/>
        <property type="gene ID" value="FGRRES_10834"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10834"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20587"/>
    <dbReference type="eggNOG" id="KOG1018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025810_5_1_1"/>
    <dbReference type="InParanoid" id="I1S250"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF179">
        <property type="entry name" value="TRNA(ADENINE(34)) DEAMINASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF86172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="173" mass="18875" checksum="A6EC4C509939B514" modified="2012-06-13" version="1">MVNEQDREHLRLAVSLAHEALKAGDAPFGSVLVSSDNKVLQTDRNRTVTGSDGDSRPDATLHPEFTLARWAQLNLSAEERKNSTVYTSGEHCAMCSAAHAWCGLGRIVYVSSTEQLEAWKKEFGVEAPVAPLSINQVAPGLQVEGPVEDLAKEVYQLHVENWTGKGFESKSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1S346</accession>
    <accession>A0A098E537</accession>
    <name>I1S346_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T21491</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325128.1">
        <property type="nucleotide sequence ID" value="XM_011326826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S346"/>
    <dbReference type="EnsemblFungi" id="CEF88892">
        <property type="protein sequence ID" value="CEF88892"/>
        <property type="gene ID" value="FGRRES_11211"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11211"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21491"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_1"/>
    <dbReference type="InParanoid" id="I1S346"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF88892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="274" mass="29953" checksum="5052B2AF1BC24947" modified="2012-06-13" version="1">MPKTIVVSGGARGIGRTIARYFLEKDYHVFILDIDEEELTYTTRTHLKTYYDAKAVSSALCDLRNTDEIHDKIQQAAEFFGGRIDVLVNNGGIAAPHWKDGKTMLDRETLNEWRAYVDTNLTAPFAVSQACLPFMTNEKDTGPVTDDSHSTAGPCIINVGSFRAKQSDPNQEGYASAKAGLLGLTHSMAVSLQPYGIRVNLVAPGRIKAAHECKEGDENGVEWAHLNEEKDVEDHLSNRAGRPLDIAQAIEYLVNAGFVSGQDLTVDGGAVMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1S3G4</accession>
    <accession>A0A098E0R4</accession>
    <name>I1S3G4_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Tryptophan synthase</fullName>
            <ecNumber evidence="3 10">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG11345.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T21835</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="3 10"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325895.1">
        <property type="nucleotide sequence ID" value="XM_011327593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S3G4"/>
    <dbReference type="STRING" id="229533.I1S3G4"/>
    <dbReference type="EnsemblFungi" id="CEF87690">
        <property type="protein sequence ID" value="CEF87690"/>
        <property type="gene ID" value="FGRRES_11345"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11345"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21835"/>
    <dbReference type="eggNOG" id="KOG1395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_3_1_1"/>
    <dbReference type="InParanoid" id="I1S3G4"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="64"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF87690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="405" mass="43501" checksum="B1A7497D8CAF6659" modified="2012-06-13" version="1">MAISEQSHSSVWPDSNGYFGQFGGNYYPSEAHQALKELAEKYEELRHQSDFLRQLEKVRTGLQGRPTPIHYLENISQQVGGAQIYVKREDLNHTGAHKINHCVGFALLAKAMGKTKLIAETGAGQHGVALATAAAYFGLECEIHMGAVDMEKQKSNVGRMQILGARVVSATAGQSALKDASDSAFNAYIEQREHALYAIGSAIGPHPFPLIVRDFQSVIGQEAREQFLAMTDGKLPEHVVACVAGGSNAMGMYSAFIEDKDVKLHAAEPLGRSSQLGEHAATLSYGKPGTLHGAKTLVIQKEEGLPASVSSVASGLVYPGIGPEMAMLHEAGRISVGAIRDEEVISTFFQMAKTEGIIIALESAHAVAYAIRLAGERPKSERIIVNLSGRGDKDVDYVLQNYGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1S3L7</accession>
    <accession>A0A098E3T6</accession>
    <name>I1S3L7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG11406.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T21983</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325823.1">
        <property type="nucleotide sequence ID" value="XM_011327521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S3L7"/>
    <dbReference type="EnsemblFungi" id="CEF88790">
        <property type="protein sequence ID" value="CEF88790"/>
        <property type="gene ID" value="FGRRES_11406"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11406"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21983"/>
    <dbReference type="eggNOG" id="ENOG502T4UY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059041_0_0_1"/>
    <dbReference type="InParanoid" id="I1S3L7"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF88790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="440" mass="45428" checksum="5C88F66FD5C5F76D" modified="2012-06-13" version="1">MGAQISVVLFNDVIQLANAVFNWPGVSVVGASVTSYYKVDAKTYNKGSAGTFTNGPFGIGSGGILSTGWISDAKDPSGTIDHDTGTDGSIYCGSGSTTNGAVLEVEIVVGQGYNGLAVEFVIGTAENLQENADTIGIYLDGVQYAVDTSNNRITVNSEYLQQPLGVTDTEFVRSTMYDHSSPPLLMGLPASPGRHSMVFAICDANNGQKDSAIMFKAGACVDCAGDIKLNYKTTTTTVGSTSFVSTIKPFITNSGTVVYGVPVEATTTSEEVYSTTTADVTSYSEEATSTAEVMSTSVESTVAETTTTADALPTSTEASTVTEKPTATDLPTTTVVSSEEPTTTDASSTETDYTTTTAITNSDQSTETSSTVESNTTTTAVTSEATAISTDVSVSQASTSIDSTTSDNSASTTVAPTMTSSQVSIPTASTLTTIRKPCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1S422</accession>
    <accession>A0A098DP65</accession>
    <name>I1S422_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG11576.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T15905</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323045.1">
        <property type="nucleotide sequence ID" value="XM_011324743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S422"/>
    <dbReference type="STRING" id="229533.I1S422"/>
    <dbReference type="EnsemblFungi" id="CEF79751">
        <property type="protein sequence ID" value="CEF79751"/>
        <property type="gene ID" value="FGRRES_11576"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11576"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15905"/>
    <dbReference type="eggNOG" id="ENOG502T1M9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037438_1_0_1"/>
    <dbReference type="InParanoid" id="I1S422"/>
    <dbReference type="OrthoDB" id="4358152at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF79751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="448" mass="50463" checksum="4DEFB7EFCB6BA751" modified="2012-06-13" version="1">MRYTTRDTAACFELLPHEILLPIVTSLPGLDTLWNLMRASPHIWRLFSSHALTITEGILSGPNSILPPKVRELIRGVILVRSKALPFRNLDEFQTQFLRGVVPIREPEDAKFITLGPESLSTSIVPLPILQSVIATAYQISVLSQACLSSYLARLKNVRPLHAFNPKPYYTHGYGPNDDWVAAWDREFVGIPAKVVDAGQPSWVEEMRALRAIWIIQLVGEIKAVVGDKIGKSWAKEDIDILSQMNAADLVERPDSSISKAEEIRTAMDYLTSLGRAQNDNYYRLPRPPPFSESPGWITASPESSKVLRAVWGYRRNGQIHRLEKGTAIPEDSTPLRRPLLSENARWEQTEEFLSRESSGVSSWAVLTIGPGNSSPIPGVKFDSFRRLGFAFWDKRRMCLLGLTWDLDGRGYSNEFYLFALESILPPDEVANLKVELRKKGQIFYSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I1S4T1</accession>
    <name>I1S4T1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T02211</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316612.1">
        <property type="nucleotide sequence ID" value="XM_011318310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S4T1"/>
    <dbReference type="EnsemblFungi" id="CEF72906">
        <property type="protein sequence ID" value="CEF72906"/>
        <property type="gene ID" value="FGRRES_11849"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11849"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02211"/>
    <dbReference type="HOGENOM" id="CLU_2574071_0_0_1"/>
    <dbReference type="InParanoid" id="I1S4T1"/>
    <dbReference type="OrthoDB" id="10286736at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF72906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="81" mass="8961" checksum="4992B75E8F74115C" modified="2012-06-13" version="1">MGIAGFSYCETERPADSDLLEAQTPLSFPGKLAYLSNPIATAKTIASEPRPTTEDGVQHRYRPSLPLKMRHKSTLMSRVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I1S5F9</accession>
    <accession>A0A098D7J6</accession>
    <name>I1S5F9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T05209</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318045.1">
        <property type="nucleotide sequence ID" value="XM_011319743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S5F9"/>
    <dbReference type="EnsemblFungi" id="CEF74410">
        <property type="protein sequence ID" value="CEF74410"/>
        <property type="gene ID" value="FGRRES_12077"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12077"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05209"/>
    <dbReference type="HOGENOM" id="CLU_2133734_0_0_1"/>
    <dbReference type="InParanoid" id="I1S5F9"/>
    <dbReference type="OrthoDB" id="10294569at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF74410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="113" mass="12759" checksum="CD691D5C8C3125B4" modified="2012-06-13" version="1">MATPSQCVHDQAYRDRRTPTFERLRVHSTCPRQAALNWSDRGEGAEAWGKVAYWCVGAPLEPLRADQDLSMSLSLSQSSSAQFSTNIRVVSMRMKILYCGVYMDSTEWDSFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I1S5S7</accession>
    <name>I1S5S7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T06639</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318733.1">
        <property type="nucleotide sequence ID" value="XM_011320431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S5S7"/>
    <dbReference type="EnsemblFungi" id="CEF75125">
        <property type="protein sequence ID" value="CEF75125"/>
        <property type="gene ID" value="FGRRES_12198"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12198"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06639"/>
    <dbReference type="eggNOG" id="ENOG502RNXK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138664_0_0_1"/>
    <dbReference type="InParanoid" id="I1S5S7"/>
    <dbReference type="OrthoDB" id="4967419at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF75125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="108" mass="12223" checksum="6EEABE4BDFAFD308" modified="2012-06-13" version="1">MNAIVDKRISWPRDPEYRIEVVMINIPFQYCPSHIANAMPPDCSGRHPYAVAIAEARFQRTPENSGGEISEIAMVEWKEMAVTFSPIPREFVTVVPLNNAIHKNQGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1S645</accession>
    <accession>A0A098DJ94</accession>
    <name>I1S645_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T14403</name>
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    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321572.1">
        <property type="nucleotide sequence ID" value="XM_011323270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S645"/>
    <dbReference type="STRING" id="229533.I1S645"/>
    <dbReference type="EnsemblFungi" id="CEF79004">
        <property type="protein sequence ID" value="CEF79004"/>
        <property type="gene ID" value="FGRRES_12316"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12316"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14403"/>
    <dbReference type="eggNOG" id="ENOG502STIN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158122_0_0_1"/>
    <dbReference type="InParanoid" id="I1S645"/>
    <dbReference type="OrthoDB" id="5070419at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025363">
        <property type="entry name" value="DUF4267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14087">
        <property type="entry name" value="DUF4267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF79004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="109" mass="11997" checksum="44BA7B0E9CEA6B33" modified="2012-06-13" version="1">MALFSPRAEYGHVGLLLEPSKTPSEAGSVSSLMYFKGIREISYGMTLVALQWQANESAVTTFSAILSIVRIGDGLVVWLNGGDELRYKAAGHWITGLGFAGWVIWRWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1S6N3</accession>
    <accession>A0A098DHC8</accession>
    <name>I1S6N3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
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    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T12077</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Nectriaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322665.1">
        <property type="nucleotide sequence ID" value="XM_011324363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S6N3"/>
    <dbReference type="EnsemblFungi" id="CEF77842">
        <property type="protein sequence ID" value="CEF77842"/>
        <property type="gene ID" value="FGRRES_12506"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12506"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12077"/>
    <dbReference type="eggNOG" id="ENOG502SQ49">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121053_0_0_1"/>
    <dbReference type="InParanoid" id="I1S6N3"/>
    <dbReference type="OrthoDB" id="4849929at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="194" mass="21408" checksum="48C71906A77609F9" modified="2012-06-13" version="1">MSRQTKTTSKQYLQPMRLWCAKILGVRAFLVFQRVQRFYSTFIVLSALVSGLALAALTFPEFHPSTGGIHIAEGFLCSSAITSLLAAVIATMLVFVFEGVEQATRTDLAVAWLPLVLLDVSIIEFLVGIVCWYCGNNIHWRGALMATQLVGLLGVCIALSLWIWFHLLKKGALGKEEREATVKPQATAPRDIAR</sequence>
</entry>
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    <accession>I1S6U7</accession>
    <accession>A0A098DGD0</accession>
    <name>I1S6U7_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
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        <name evidence="2" type="ORF">FGRAMPH1_01T11419</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322976.1">
        <property type="nucleotide sequence ID" value="XM_011324674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S6U7"/>
    <dbReference type="EnsemblFungi" id="CEF77512">
        <property type="protein sequence ID" value="CEF77512"/>
        <property type="gene ID" value="FGRRES_12570"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12570"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11419"/>
    <dbReference type="eggNOG" id="ENOG502RY5I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_2_1"/>
    <dbReference type="InParanoid" id="I1S6U7"/>
    <dbReference type="OrthoDB" id="64477at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43415:SF3">
        <property type="entry name" value="GNAT-FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43415">
        <property type="entry name" value="SPERMIDINE N(1)-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="205" mass="23314" checksum="27A6F3ECD0C94EB1" modified="2012-06-13" version="1">MDLNNIPKTYSSERLIYRALENNEQDTAYIFKFHENDPFNTALSDHSLLRPRNKKSSEDLITAIQKASLSVMVCLSPSEAQAQDIESSDPVPIAFAILGWGGIPAGREHHRSTSLGITLSDPYQGKGYGSEVINWLLDWAFRYGGYHRVGLSTVAFNTRAQHVYSKLGFKEEGREREAVYFDRAWHDMINYSMLEHEWAALRGVK</sequence>
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    <accession>I1S6X1</accession>
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        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
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    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T16153</name>
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    <organism evidence="2 4">
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323156.1">
        <property type="nucleotide sequence ID" value="XM_011324854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S6X1"/>
    <dbReference type="EnsemblFungi" id="CEF87121">
        <property type="protein sequence ID" value="CEF87121"/>
        <property type="gene ID" value="FGRRES_12594"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12594"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16153"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_1_1_1"/>
    <dbReference type="InParanoid" id="I1S6X1"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF4">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF87121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="269" mass="30203" checksum="40B279E1A7AA0DB6" modified="2012-06-13" version="1">MQKQAFIANRKLMRERLENNEEICSKLIPDFEVGCRRVSPGNGYLESLIKPNTKAVFGGIKCMNESGSMDNNNIQHDFNIIICATGFDVSHRPAFPVLGCGGQNLRDVWSQGPTHYLSVAAPGFPNYWIAGGPNAPISNVSLIMGLELAVDYAFSCVRKMQAEGIASLEVEEDAAKEFMEQRDKIMKDLVCTDSCASWYKNSKNDNSVTGPWCGSIWHYKEALENPRWKDYKMKYLGKNRFAYFGNGRTVPELRGESMATKYLNEIGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1S6X5</accession>
    <name>I1S6X5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T16169</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323164.1">
        <property type="nucleotide sequence ID" value="XM_011324862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S6X5"/>
    <dbReference type="EnsemblFungi" id="CEF86741">
        <property type="protein sequence ID" value="CEF86741"/>
        <property type="gene ID" value="FGRRES_12598"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12598"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16169"/>
    <dbReference type="eggNOG" id="ENOG502ST09">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054614_3_0_1"/>
    <dbReference type="InParanoid" id="I1S6X5"/>
    <dbReference type="OrthoDB" id="5343383at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF86741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="270" mass="31760" checksum="26F67FE68B241FC2" modified="2012-06-13" version="1">MAPLSENSYSPAEIAAILLDFYLFLTIIYYDAQYLKLPSAEGWTDMEPLLESLGSSDMVGQVIKRIPYFDNDCKAFIHYKSRLVDYPTLPQSCFKRVMWGRVSSSDEIYSERRQIIIDMRDVFPLATGREAWGKYIWLNVRDGEITVEERLMHDLLQVDLKVFFDGVKQDYIALKLIPCRRRITIEADKIEERLGEEVITEEEVIAQDGAWGTALDIHYTRQLYRAFGWPLAFRKYEAFDAVDRLMDKLGEHRNEWEPTEEDWDDDDHWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I1S793</accession>
    <accession>A0A098DX29</accession>
    <name>I1S793_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T17663</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF85902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323858.1">
        <property type="nucleotide sequence ID" value="XM_011325556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S793"/>
    <dbReference type="EnsemblFungi" id="CEF85902">
        <property type="protein sequence ID" value="CEF85902"/>
        <property type="gene ID" value="FGRRES_12716"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12716"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17663"/>
    <dbReference type="HOGENOM" id="CLU_1468275_0_0_1"/>
    <dbReference type="InParanoid" id="I1S793"/>
    <dbReference type="OrthoDB" id="10335197at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF85902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="184" mass="20487" checksum="A1C05E734B123669" modified="2012-06-13" version="1">MNDESHYVLFGNTAWQIPSLPDMTASLGLMASQICLELEASSAISAPSIVPGSRVPSMSRSGGWNVAATFDFERSEKRWSSAHPQNRKQNRLLMQESVYGLPSAELISFWTFHGGTAIQGKIRQRQQVNVEASIEERPMAKMEVRSSFIRGPRGNIGFYDYGDKENSLFALHMDGCELRANKNA</sequence>
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    <accession>I1S827</accession>
    <accession>A0A098DUX2</accession>
    <name>I1S827_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
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    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T23381</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326530.1">
        <property type="nucleotide sequence ID" value="XM_011328228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S827"/>
    <dbReference type="EnsemblFungi" id="CEF85650">
        <property type="protein sequence ID" value="CEF85650"/>
        <property type="gene ID" value="FGRRES_13003"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13003"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23381"/>
    <dbReference type="HOGENOM" id="CLU_2085055_0_0_1"/>
    <dbReference type="InParanoid" id="I1S827"/>
    <dbReference type="OrthoDB" id="10294038at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF85650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="117" mass="12793" checksum="3DB95E3F3385092A" modified="2012-06-13" version="1">MQVRKDKRRRVSKEEKLHCSATPRKSIQGLIDDQFQVLVRLEDIVNADADADADADAGPKSDSRRVGQTLPLTMHPIGIPKSAAKPLENSIVDPSHAVPCSDPSTSKERRQTVGLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I1S8I7</accession>
    <accession>A0A098DSY6</accession>
    <name>I1S8I7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
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    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T25139</name>
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    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
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        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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    </evidence>
    <sequence length="146" mass="16424" checksum="22A627D1DCF0AA07" modified="2012-06-13" version="1">MCNQRTEKWVCKHCEKPVKKVTYLTSKCKSQSETGVCKEAGKTCYETIDIYIPTCTPKQLSKLQTPSTAHSNTLPRSSDSNHSVCVKQSKLHGYAPHAPRRFWKKKSKKNVCESVKKGGICTQASPTLLDYVYVTDADCDICKQMN</sequence>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_011320680.1">
        <property type="nucleotide sequence ID" value="XM_011322378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S9A4"/>
    <dbReference type="EnsemblFungi" id="CEF76401">
        <property type="protein sequence ID" value="CEF76401"/>
        <property type="gene ID" value="FGRRES_13434"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13434"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09197"/>
    <dbReference type="HOGENOM" id="CLU_2133737_0_0_1"/>
    <dbReference type="InParanoid" id="I1S9A4"/>
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        <property type="component" value="Chromosome 2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="113" mass="12825" checksum="0FD4D28BC66EB4B2" modified="2012-06-13" version="1">MTDPSTPTQYTSLAAFRDEGLGGFLTDCTVYVLFSVFLCCANRPGSKDWGACQHRGDASHTHSWKELFHCYCSGLDYGLLFASWLGYAIGYWIDWSYVKAIVNEAWKMLRGCW</sequence>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
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    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_011328824.1">
        <property type="nucleotide sequence ID" value="XM_011330522.1"/>
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    <dbReference type="AlphaFoldDB" id="I1S9F9"/>
    <dbReference type="STRING" id="229533.I1S9F9"/>
    <dbReference type="EnsemblFungi" id="CEF84919">
        <property type="protein sequence ID" value="CEF84919"/>
        <property type="gene ID" value="FGRRES_13490"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G28195"/>
    <dbReference type="eggNOG" id="ENOG502QTMI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017168_1_0_1"/>
    <dbReference type="InParanoid" id="I1S9F9"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:deoxyribonuclease (pyrimidine dimer) activity"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:heteroduplex DNA loop binding"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:nucleotide-excision repair"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004601">
        <property type="entry name" value="UvdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00629">
        <property type="entry name" value="uvde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290:SF5">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03851">
        <property type="entry name" value="UvdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0228">DNA excision</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="527"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="602"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF84919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="620" mass="70316" checksum="DE71A449DF91B249" modified="2012-06-13" version="1">MTQKRKRTGAHPPPPIPDMPDTVPRRSSRRLKESTDERTPKIDITKMASNPMKLTNTKKVKAVWDTGEGVEEAMRELSEMEHKLQDAVRTQRLAVESSDLHVKKEIAQEPSIRPKVNAPNNNNTVAARGKLNGKPKAVETAPQDEHDAELATDDMAEAKEENGVNRGANRPPPVNSDTLPLPWKGRLGYACLNTYLRNATPAVFSSRTCRISSIIEHRHPLANPDEPEHATKNRPDKSQPADNERGLKYVQELGLANARDIVKMIRWNAKYGIKFMRLSSEMFPFASHQEYGYKLAPFASEVLAEAGKVAGELNHRLTTHPGQFTQIGSPRKEVVTAAIRDLEYHDEMLSLLKLPEQLNRDAVMILHMGGTYGDKAATLDRFRENYARLSDSVKRRLVLENDDVAWSVHDLLPICEELNIPLVLDFHHHNIIFDSSIREGSKDIINLYDRIRATWTKKGITQKMHYSEQTSAAVTPRDRRKHSARVKTLPPCAPDMDLMIEAKDKEQAVFELMRTFKLPGWDTFNDMVPHERPDESRKAIKKKPKKGKKKTAEVNGEAEDDIEVPEKIVSAEDFGMGGPQGRVYWPEGMEEWLRPKKREIKKAKEGKDESPKMKEEGDED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-05-01" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q4HZ47</accession>
    <accession>A0A0E0SFZ4</accession>
    <accession>A0A1I9FQ50</accession>
    <accession>V6RQU8</accession>
    <name>ESF2_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName>Pre-rRNA-processing protein ESF2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>18S rRNA factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ESF2</name>
        <name type="ORF">FGRRES_09761</name>
        <name type="ORF">FGSG_09761</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS231668">
        <property type="protein sequence ID" value="ESU16357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970335">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327959.1">
        <property type="nucleotide sequence ID" value="XM_011329657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4HZ47"/>
    <dbReference type="FunCoup" id="Q4HZ47">
        <property type="interactions" value="937"/>
    </dbReference>
    <dbReference type="STRING" id="229533.Q4HZ47"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01G30187.R37">
        <property type="protein sequence ID" value="FGRAMPH1_01G30187.P37"/>
        <property type="gene ID" value="FGRAMPH1_01G30187"/>
    </dbReference>
    <dbReference type="GeneID" id="23556697"/>
    <dbReference type="KEGG" id="fgr:FGSG_09761"/>
    <dbReference type="eggNOG" id="KOG3152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054086_0_1_1"/>
    <dbReference type="InParanoid" id="Q4HZ47"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001147">
        <property type="entry name" value="Pre-rRNA-processing protein esf-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000285373" description="Pre-rRNA-processing protein ESF2">
        <location>
            <begin position="1"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="118"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="321" mass="36276" checksum="2AE27FB7B448E6DF" modified="2005-08-16" version="1">MAPETKNDFLEIADSDADSDIGYNSEEDDMQKGGRGAKRRKVESDDEDDPGSDIGSDDEDEATEKDSKKTQEEDKKEDQPEKPKRKSKDTTSTELPDVTRTLTKKNLVASEAAIKKSGVVYLSRIPPFMKPAKLRSLLEPYGTINRIFLAPEDPASHARRVRAGGNKKRSYTEGWVEFTKKKDAKAVCDLLNARTIGGKKGSYYHDDLWNLLYLKGFKWHNLTEQIAAENAERSSRMRAEISKSTKENKEFVRNVEKAKMLDGMAVKAKAKKRKAETHTEGQEDESVRQVKRSFKQVPLAKKKMDGEDQPAEVTRVLSKIF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q4I7X1</accession>
    <accession>A0A0E0SF71</accession>
    <accession>V6RDX2</accession>
    <name>PFS2_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName>Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PFS2</name>
        <name type="ORF">FGRRES_06687</name>
        <name type="ORF">FGSG_06687</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS231666">
        <property type="protein sequence ID" value="ESU12813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326320.1">
        <property type="nucleotide sequence ID" value="XM_011328018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4I7X1"/>
    <dbReference type="SMR" id="Q4I7X1"/>
    <dbReference type="FunCoup" id="Q4I7X1">
        <property type="interactions" value="233"/>
    </dbReference>
    <dbReference type="STRING" id="229533.Q4I7X1"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T22917">
        <property type="protein sequence ID" value="FGRAMPH1_01T22917-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G22917"/>
    </dbReference>
    <dbReference type="GeneID" id="23553809"/>
    <dbReference type="KEGG" id="fgr:FGSG_06687"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22917"/>
    <dbReference type="eggNOG" id="KOG0284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_77_1_1"/>
    <dbReference type="InParanoid" id="Q4I7X1"/>
    <dbReference type="OrthoDB" id="16717at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001039">
        <property type="entry name" value="Polyadenylation factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002008">
        <property type="entry name" value="Polyadenylation factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000238503" description="Polyadenylation factor subunit 2">
        <location>
            <begin position="1"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="135"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="177"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="218"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="260"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6">
        <location>
            <begin position="303"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 7">
        <location>
            <begin position="373"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="424"/>
            <end position="450"/>
        </location>
    </feature>
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            <begin position="486"/>
            <end position="514"/>
        </location>
    </feature>
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            <begin position="544"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="612" mass="66452" checksum="AEACB25BA6DE72CE" modified="2005-08-16" version="1">MAYEPRGDHGGGGGGQGQDGAFVKVRGRRPVTDYGATITHWQHDRAPGYKGGYTGEAERPSASYIVDMLPPAARVTKAADSIPIKHLHSSLNKIKHPINVVRWTPEGRRLLTASTSGEFTLWNGTGFNFETIMQAHDSAIRALEYSHSDDWLISADHDGAVKYWQPNFNNVQSINAHTDPIRDLAFSPSDSKFVTASDDSTLKIFDFALGQMESKLEGHGWDAKSVDWHPTKGLLVSGSKDHLVKLWDPRTSRCLTTLHGHKSTITKVLFEKVRGACLATSARDQTARVFDLRMMRDICLLKGHEKDISTLTWHPVHPNLLSTGGMDGSLFHYLLDSPNPPPGQSFTVAPYDSPDPTTVPAQSVWPTHKVPYAHDYAIWSLDWHPLGHILASGSNDRITRFWSRARPGDAEVFQDRYHIGEAAAEAQGTWDRRGGRRQRQEEEQQEMEDEMDALVDQDAPKAGVPGLPGIPGLPLGGLPGLGSAVPPPPIPGVGAGGPPPPLPFPLPGLNGSLPPPPLPGLDPNNPPDPAQLLELMKKAGVPLPPPGALPPGLLPPGGIPPPPGGFGMPIPPPPMSALEAEKAENVRRRAPLPSQEDSLRHEQRQGKYTRAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-04-25" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>V6QX21</accession>
    <name>ATG22_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ATG22</name>
        <name type="ORF">FG012251</name>
        <name type="ORF">FGRAMPH1_01T03029</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2017" name="Sci. Rep." volume="7" first="11062" last="11062">
            <title>Genome-wide functional analysis reveals that autophagy is necessary for growth, sporulation, deoxynivalenol production and virulence in Fusarium graminearum.</title>
            <authorList>
                <person name="Lv W."/>
                <person name="Wang C."/>
                <person name="Yang N."/>
                <person name="Que Y."/>
                <person name="Talbot N.J."/>
                <person name="Wang Z."/>
            </authorList>
            <dbReference type="PubMed" id="28894236"/>
            <dbReference type="DOI" id="10.1038/s41598-017-11640-z"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="1 5">Vacuolar effluxer which mediate the efflux of leucine and other amino acids resulting from autophagic degradation (By similarity). The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Vacuole and punctate structures (By similarity).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Significantly decreases the radial growth of colonies under nutrient-rich conditions (PubMed:28894236).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATG22 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316999.1">
        <property type="nucleotide sequence ID" value="XM_011318697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6QX21"/>
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        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="229533.V6QX21"/>
    <dbReference type="GlyCosmos" id="V6QX21">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T03029">
        <property type="protein sequence ID" value="FGRAMPH1_01T03029-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G03029"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01225"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03029"/>
    <dbReference type="eggNOG" id="ENOG502QR9I">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="V6QX21"/>
    <dbReference type="OrthoDB" id="192733at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17483">
        <property type="entry name" value="MFS_Atg22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044738">
        <property type="entry name" value="Atg22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0029">Amino-acid transport</keyword>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000443921" description="Autophagy-related protein 22">
        <location>
            <begin position="1"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="7">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="topological domain" description="Vacuolar" evidence="7">
        <location>
            <begin position="113"/>
            <end position="155"/>
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            <end position="208"/>
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    </feature>
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    </feature>
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    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="7">
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            <begin position="431"/>
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            <begin position="447"/>
            <end position="467"/>
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    </feature>
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        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
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        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="7">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="516"/>
            <end position="536"/>
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    </feature>
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        <location>
            <begin position="537"/>
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        <location>
            <begin position="555"/>
            <end position="575"/>
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        <location>
            <begin position="576"/>
            <end position="583"/>
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            <begin position="584"/>
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            <begin position="605"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="78"/>
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    </feature>
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            <begin position="615"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="632"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P25568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="28894236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="28894236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF73316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="657" mass="72241" checksum="800F835FB87CCD09" modified="2014-02-19" version="1">MAPNLQPQPQSQLQRPRLKDHRPWSGLSNISKRSFRSCATSAFEADDERSSSDGDMSPRNSEADLRRPVVPRHFGHDARPTSRRELLGWYAYAFAAETYVICGIASFIPILLETLARENGVLVSDRKTPCGSSDSKNDGDGQCIVWVFGMEINTASFAMYTFSVSVLVQALLVVSISCAADHGNYRKKLLLTFAWIGSFAVMSYIFITKDNYILGALLTVISNTSFGASFVLLNSFLPLLVRYHPDVIEANVATTPDLGSSEFESRPLDQSVGQLESSPVTATSPLLHPEDGGRLKPTASHAEITSKELELSTRISAIGIGTGYIAALFLQCICIGVLISLHNTTWGQRVVLFMVGVWWTVFTIPAAMWLRPRPGPPLADNGRKGIMAGLAYILYAWKSLFKTIQQARRLLDIVLFLAGWFLLSDAIATTSSTAILFAKTQLHMKPWALGMINVISTTAGVFGAFGWSWVSRLFNLKAHQTILVCIALFELIPLYGLLGYLPFVKNWGVFGLQQPWEMYPLAAVYGVVLGGLSGYCRSLYGELIPPGSEAAFYALYAITDKGSSVFGPTIVGAIIDRTGTIRPAFWFLAVLVGFPAPLIWFIDVERGRREGAKLAKSITDSIVQEEDESDDGAERRGMLSDYEREHGQSIDDERAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>V6RBG5</accession>
    <name>V6RBG5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG05953.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T19151</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324564.1">
        <property type="nucleotide sequence ID" value="XM_011326262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6RBG5"/>
    <dbReference type="FunCoup" id="V6RBG5">
        <property type="interactions" value="678"/>
    </dbReference>
    <dbReference type="STRING" id="229533.V6RBG5"/>
    <dbReference type="EnsemblFungi" id="CEF86719">
        <property type="protein sequence ID" value="CEF86719"/>
        <property type="gene ID" value="FGRRES_05953"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05953"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19151"/>
    <dbReference type="eggNOG" id="KOG3888">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021859_0_0_1"/>
    <dbReference type="InParanoid" id="V6RBG5"/>
    <dbReference type="OrthoDB" id="406634at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF25">
        <property type="entry name" value="OXIDOREDUCTASE AIM17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="8">
        <location>
            <begin position="62"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="179"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF86719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="494" mass="56749" checksum="D499BB0CB6327AFB" modified="2014-02-19" version="1">MFSRRLATQSCRAIPRGFSLTRIHAQNATTYRRIISKPPPQFKVRDSFKTYNDSLTISSSGRSIFMVDSEKGWTKLDAMLLRDSCTCAACVDTASGQKTFATTDIPSNIAIDKIRKTEEGVGITFKNDMYPDHEMVFPWLSVSQAMGHQKVPKMPFPRQELVFPKTGRTFWDKAIIQERVRKIDYHEFMKGSDAFWHTILDLSNLGLVFLKNVPQDENSIVDITTRIANIKETFYGRTFDVRAKPDAENVAYTSGYLGLHQDLLYLESPPAIQLLHCMENSCEGGESLFSDGLFAGKLLFLQSSPTIRNLWKVMVPYHYEKHGYFYHQRRPILELGPNENLAGVNWSPPFQDQFSSAAVDAREWLEPAKLFDRMINNPDVMYEMKMEPGECVLFDNTRIMHGRNKFDVGGGSRWLRGAYISREDFVSRALHVPEELATEYRAGKKWSRDIEDQEVRGSEWFGKTSEQVDEVIEGLKKDKSIDTMKSRDFELLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>V6RGQ1</accession>
    <accession>A0A098DV44</accession>
    <name>V6RGQ1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG07209.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T24235</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326936.1">
        <property type="nucleotide sequence ID" value="XM_011328634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6RGQ1"/>
    <dbReference type="EnsemblFungi" id="CEF85214">
        <property type="protein sequence ID" value="CEF85214"/>
        <property type="gene ID" value="FGRRES_07209"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07209"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24235"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004790_4_1_1"/>
    <dbReference type="InParanoid" id="V6RGQ1"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF85214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="614" mass="67880" checksum="14359BC0EC4EC793" modified="2014-02-19" version="1">MAPTGDAMGETVAAAGLHAEMVDEKRASVAAERRSSVVTDPQAPAAAVSSGGVTADGQFPTPEEMQSLRRIANKIPMKLFSIAFIELCERFSYYGCTVVFTNFIQQPLPPGSTTGADDEQPGALGMGQRASTGITTFNQFWQYLMPLLGAYLADQYWGRYKTISYALVVDIIGHLILIVSAVPGVIQSDGALGAMIVGIIVIGFGTGGFKPNVNPLIVEQLGEQYMHVKTLKSGERVIIDPAVTIERVYMWFYWAINIGALVGQVTMVFAEKYVGFWLSYTLPTFMLCICPIILFFNRKNYERRPPGGSVLGPAMKTFFLAQKGRWSINPFQTWKNMHTGDFWENVKPSRFSHENRPKWMTFDDAWVDELRRGFNACAVFCWYPIFWLCYNQINNNLISQAALMQRHGVPNDILSNLNPFALLIFIPLNDRLIYPALRKAGIRFTPIKKITAGFFTGAAAMIWAAVVQHYIYQKSECGMRASGEDCPVVEINVWAQTGAYVLIALSEVFASITSLEYAFSKAPKNMRSMVQAVALFMTAFSAALGQALVGLAADPLLVWNYGVVAILAVIAGTCFWFQFKDLDIIEDELNALPEGQAGAKFDEESPLGEKRVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D091</accession>
    <accession>A0A0E0RKT2</accession>
    <name>A0A098D091_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG00031.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T00115</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF71857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A098D091"/>
    <dbReference type="EnsemblFungi" id="CEF71857">
        <property type="protein sequence ID" value="CEF71857"/>
        <property type="gene ID" value="FGRRES_15679"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00115"/>
    <dbReference type="InParanoid" id="A0A098D091"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010018594" evidence="2">
        <location>
            <begin position="17"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1273"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF71857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF71857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1406" mass="144076" checksum="494D1A52F1109C4F" modified="2015-01-07" version="1">MKRSLLLALWSTGVLGGPCKPSKPSETSIADGTPTQSNHISLGLSSTYGDSTKTGQDSAHDTSTGTSPHESGQISVSIPFSESDLNTNTQDAVSNTIGLPEGSVTGTGSFPEPTSEGGSVPGTVTDGDSEETSGGAGNSGSPSSPQTDGSFPTGTADFPGEHSGTVTNPDASGTATGPEDSGNPSGTASGFPEQSSGTLVNTEVSGQPTGTADVPGGPGATDANTATDLPTTIPSDVPGGASDTATNPEGSGPSGTATGPGEAGTTASGGVPGEASGTSPQDSGASDTATIPEGSGPSGTATVPGEPGTTDSPTGISEGVSDSSSGTATVPGEADNTASGGVPGDASGTSPPGSDANPTEVATDGTSNGGPTVSHDPTNTPGSPEETVSNPATGTEQGQDTATQTDAAPSTEVAPTGIDTSIAGPATTAPGNTLPNDQGTLTQSNGDEFTSAAPGDATEDHSGAVTTDANGAPTTLPGNQDQTTGSPEQSTSASSDQNSDGNSNETSLGQEDSSAASTTDGNAAQPTTEGDGVTTKPVADNTDASSTGSSEVNNGATTTGSGPVETTDFDGVPSTTVPAPSATANPVTSAATTDTDMPVVTEAPPGFNPSTVIGHPEWTTNTWITTTTSEGSDPTVVPVLVGCNDCGGGGSGIILWGFPPVINTWFQLPNLPKFSFPCIPPASGCTSTPVTEETGEDDDDDDDDDKSSTTCTDKATVTDCFVACTTYTGPAGVSVTPECQTTCTKTHTGCSVTGTTTTSSAAACGPSGDSECTTCNVDLTANDDSESLKRRSLERRGGIDIKKNIAGCDWSNTPVGAPRFPAYPGGNLVLNNEAAIVSQNSPLNQIKRWWRTTRDTNCVPSLNNIGEASYPKTGLTDVEGPSIDHVYEKSMLLDFWRFIIDPAAAAVVGMKTGTPNKINCDDIKSYGGINSGSNLIQKVFDTYPGSAEVLMPNNAQFMDDFIGMDQWTNGNAKAQITDPQGTKTQADKKASNGKAVRANTNIANAKRWIEDKMLFLEALAIGVEMFNVDEAKNALIRQNLRIYQTLVDMDENAKNCMKDDAVINGVWSFADKYQTFMADRFTGNQDYSMNQGVVYAKNKLITALTTDVANAANIANIPAGDLTSWQKRLANMQDASRVWEVSVTFVWAGPTTSKRDTDGLSCDRPNPSFTTESTVEPTTDFTTFATSMRPSSDIVTSDEVPSTTEQVTSSKNPPLLTDLPSLTQQVPDTTISTPDGSSCAETATVTNCNVGIGGGHGGPACVERETCNSWINTKTTSTTPSPTPTLAKPDPGLNEKHCYNSGQQSNYEAITYAAESFCRDVVNDQVQGPVWSNYKLEGKKTPSTGYHFKLAFQVNEGCVWTANYDECMRYMKVPIDSCNCSAKGNKQGGWVENNCIMARIDPNSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-06-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DAK1</accession>
    <accession>A0A0E0RXI4</accession>
    <name>A0A098DAK1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T08311</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DAK1"/>
    <dbReference type="EnsemblFungi" id="CEF75959">
        <property type="protein sequence ID" value="CEF75959"/>
        <property type="gene ID" value="FGRRES_15612"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08311"/>
    <dbReference type="InParanoid" id="A0A098DAK1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF75959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="77" mass="8249" checksum="73F95E5988C4D1FC" modified="2015-01-07" version="1">MAEQNDDDNDEEALCHGMAMGWAVMDGVEDAMEAQKKQVLNCRMPVRAQASLRESKSAPPGVAQTGNVGSLVLSMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DBJ2</accession>
    <accession>A0A0E0RYG8</accession>
    <name>A0A098DBJ2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG08041.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T08981</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DBJ2"/>
    <dbReference type="EnsemblFungi" id="CEF76293">
        <property type="protein sequence ID" value="CEF76293"/>
        <property type="gene ID" value="FGRRES_08041_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08981"/>
    <dbReference type="eggNOG" id="ENOG502SMMT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DBJ2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925">
        <property type="entry name" value="GLYCOSYL HYDROLASE 43 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010018632" evidence="5">
        <location>
            <begin position="23"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF76293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="557" mass="61416" checksum="3E189F5E468A090A" modified="2015-01-07" version="1">MLFLLLPVVLLALLRSSAQTQAKPLEPDSSVAYATYINFAEHDILDNDDGLPTHPLLTDYGKVTYPITTDGNGREQVEAHLSYWEGKYWMYAATWGCGGSIFVYGRLTGMNWPASPTYPKGDYGEDGNCGIKSYMSSDLVNWQLTDFYQPAAEVANVTKPLVRYSKATGNYVLFMGGNAHSNFYYATSKSPGGPWSNPPSLMTGEYLTHDFDIAVGPDGAHYILTDTWTSVSEIQATGHSVPVWDIYVQKLAPNLTSTVGTNSTSKLIRTAKELLKQGLNLEACGFFYHDSYWYQTYSYTCQNCAEYIYYLYAKDPLGPYTDGGYLSLDGCGGQNKGANVLPSAKGPIVVAGNLAYRTSPTDHVVNGEIWHADNHQAASSTSFFPLEFNDDHTIKNFTCPATVKIPLVKNITSSPEPPLPYQLDCRIRNWQTTVQHFSPAKQVSTLEFPVWQRTDNLGPTTNAGPVLDGILNVTVSFLDKTTETFSWVPSNISWAPAKISLDLHDKKLSSIELSTNATNGCYGTLAQPLVDSGVQYGVIVNKKLKVSEKAQMYIYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DBP8</accession>
    <accession>A0A0E0RX97</accession>
    <name>A0A098DBP8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 1, complete genome</fullName>
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    <gene>
        <name evidence="7" type="primary">FG10450.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T08137</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DBP8"/>
    <dbReference type="EnsemblFungi" id="CEF75872">
        <property type="protein sequence ID" value="CEF75872"/>
        <property type="gene ID" value="FGRRES_10450_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08137"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A098DBP8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04733">
        <property type="entry name" value="OYE_like_2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051799">
        <property type="entry name" value="NADH_flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
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        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="8"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF75872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="423" mass="45712" checksum="106C8BA384CE22D6" modified="2015-01-07" version="1">MSELLLSKPLQLQCGLTLPNRLIKAALAEEMADRQNLPTTAQMERTYGAWAEGGWGMVMTGNVQVDNKYLGGFGDCSISTDLPEEKVLEAYKHFVGICRKNGVPTLMQINHPGRQSPLGAGTKSYMAKNLAPSAVPLNIGDDIISKIISTVVFGTPKEMSVAEIEDVVQRFAKTACIASESGFDGVEIHAAHGYLLSQFLSEKSNKRTDQYGGSPAARAKIIVDVCKAIRAATPATFCVGLKFNSADHQSPKELEECLEQMTLIAEVGLDFLEVSGGSWENPTMFTGTGEKKSASTAARESFFLEFAREMRAKLPNTPLMVTGGFRTRAGMEEALSEGACDLIGLGRPAIVNPFLPANLILNKEVKDDDARVFAKRIQTPWLLKKFGPKSIGSGAEIEAAAVNWEVNVDLGGVCVLIDLYTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DEG3</accession>
    <accession>A0A0E0S1G9</accession>
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        <name evidence="5" type="primary">FG08883.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T11083</name>
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    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DEG3"/>
    <dbReference type="STRING" id="229533.A0A098DEG3"/>
    <dbReference type="EnsemblFungi" id="CEF77344">
        <property type="protein sequence ID" value="CEF77344"/>
        <property type="gene ID" value="FGRRES_16949_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11083"/>
    <dbReference type="eggNOG" id="ENOG502QUGB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DEG3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
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    <dbReference type="PANTHER" id="PTHR15241:SF304">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241">
        <property type="entry name" value="TRANSFORMER-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="104"/>
            <end position="182"/>
        </location>
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    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="286"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="57"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="529"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="691"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="770"/>
            <end position="791"/>
        </location>
    </feature>
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        <location>
            <begin position="913"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="694"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="940"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF77344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="952" mass="106621" checksum="C4BC77F74494087B" modified="2015-01-07" version="1">MYYTSRIPSGSPSHHLSNAKSLPALAKPAYDSPELDEDYDDGVQPFWGYPPSQVDHNQEAETTPFQGAQHGESQIQSAATDVTSRPFTKSRRTFDAQAVYPAEACLFVANLPQNVDDVTIERDLTVFFSRYGTVFIKVKRDRRLMPYAFAQFTERTHADFALQHASGLEILGRYPRLEKCGGNLSYIIFRKDKLPVQYDDAYNIFSPYGKIAKIETLDYKVQIKLHVPPSMMVQYERFDPKRDVIKSFGHSDVFIIMLYDPKIGQDPSERTSGDRTFMEIYDKNRRSIFMGNMPAHTDERLVNKLASQCGDVASVDLRSIPDANGGAPNVYAFVEFERPNAPDEAVRQFNGTHVEGSILRVERRRTRPPRDTRSFSVSQSMRPLPLVPHLRPGRASSMAFEAVDQQNEHCSTDSTSSTLVEHETNHSRTGSVDTTAPVDHHGHHSRLGSTVATPIAQPSRLDSMVATPQPRHLGPMAATQLSQHNRSVSMAATCFGHHNRSVSMAAAPIAAPSRSVSMAVDAPINQQRNHNRMKSSDRIPTIPQNARPLPVQPEHPRRAFLSPNKMLAFGAGELDEYTPINSPDKVSGPNVTGNNVHWGQSQFIEASPEYFSPAGSSPIHHEPHDTQIGSFAERLATQGSRSVSYAFSSAAQHAIDRCETAVEDKKNDDIKGHRRGPSALFPTAPALHLEVTDSDGSSSWRTIGSSEEEEGFKEKKAESRTKLRRGCLSEQNLKRNELAYKEVNKDHKSEENLKVKKRVSFKSETSIIYHSPESSNQTSIHQASSPSSYVGPQLQAQMMTPALPPPPGGLVYVAVPESVATQLSNAHFYGYPSHQHEAQYQAPHRVYQNHPQAHYQVHNQVHNQTFYGESAGAMYRAQPQVPFGESVQTPYYGYTRPAYDDRTVRYQNPRVQYRRSQLGDPQGNPYASYAPAESPHQRRQRVEAERYRRYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DFH7</accession>
    <accession>A0A0E0S2E8</accession>
    <name>A0A098DFH7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T11739</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DFH7"/>
    <dbReference type="EnsemblFungi" id="CEF77673">
        <property type="protein sequence ID" value="CEF77673"/>
        <property type="gene ID" value="FGRRES_12542"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11739"/>
    <dbReference type="eggNOG" id="ENOG502RWZE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DFH7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="348" mass="38828" checksum="8DB540556F01E8AA" modified="2015-01-07" version="1">MKQVIKRIRTDGYTITQQDLEFVDREQDEWLQQWTPDPIFDKKVKDAREAYKGLRPRGTNGPVDDDDVNDDGCFDQLRRLNPQEYIAAEKASQCHSGPVGSQRPPTDLGPFTHDPIAGTELNVGLDNDSQDDDRLIAASYESGLIEDQDDDVINILTEGDYCLQVWGRKELIQLDGTIVRVRKPLVPMRCVKVLARCTQPDLQETTDEVEAVEEDEEDEEVDGPNRIADNTAPEAVIAGYSGITGCPVFATPPSMGTIRSTIDMSDNSQGISFRTEHMNHLTDGNVIWHEMSTVPGNISAIKRLVMSNDRNFIDDDDVASTIALQHKRLNLGLSFEPPAHHRAAEDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DH49</accession>
    <accession>A0A0E0S423</accession>
    <name>A0A098DH49_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FGRAMPH1_01T12891</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DH49"/>
    <dbReference type="STRING" id="229533.A0A098DH49"/>
    <dbReference type="EnsemblFungi" id="CEF78248">
        <property type="protein sequence ID" value="CEF78248"/>
        <property type="gene ID" value="FGRRES_16267"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12891"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DH49"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Type VII secretion ATPase EccA"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050773">
        <property type="entry name" value="CbxX/CfxQ_RuBisCO_ESX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN / ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392:SF2">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN _ ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="518"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="798"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="61"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF78248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1070" mass="120390" checksum="44F4314E711B8CD1" modified="2015-01-07" version="1">MVNCPRCLELHSQLIFNGSSGTEARTIQQVLVATNPTNIMTMGETDHSSASSEQDDPSNQCPDAKSSPYRTPETGSVSTGDLPKTPLSAHPSTHIHSDSTTLENIKPGEAQAVADSIANLFVEAVASRLSKLKSLEEDANQTVKHDQDESSKDSHSSEEKDNHENNDDSDKEDNSEKDEEKELKWTEDDSLLLKEEDFESIADKSLSQIEWSRRKREESQQNEPLDRVMCMIGHEESWNNNLNDWSFDIVLKGVYEPGISATLSTNSWAILEGLTEGTSVSFTAVNSPSSQDSMATVVFFSNADKIDQESEIEEIMRVAKKPEFRTVTILSYEVLGNSSKEALDVNEEPKRRFSNRLIVDDYGEKETIKFMKILCRSKPEYRFESDDVLEILAQQIHKRQCGDQFKNPNTLPREIEKVWKKSQARVQDAWYSWAKTHSPGDGHEFPAEGDNRDEIILVDILERPPAPEVEDSRVDSPAWKSLQQLVGLKSVKEKLELIFDMAVYNKHQEKHGRQPLATTYNRCFLGSPGVGKTTVAELYAKMLSELGIISWGHIITKRASDLISVYIGGSEARTTRALDEAKGGVLIIDDAHLLYQDPSRNESPDSFRNGIIDTLVANISGTANEDRCVILCGYAEMMEAMFLRTNPGLQRRFPIENSLHFENYDEEQLHQILKQKMERDNLIATDEADVVARETLSRMSRRPNFGNGGDVENLLSRAKVHRITRLKGSNIDFADFHKQALQPQDFDPDFDRPRRADEHRNSLFQDFVGFDSIIGQFRGYQKMADGMRRCGVDPKSFIPWTFIFSGPPGTGKTKIYIFANKEDRTTARKVGRLFYDMGFISSSTVVTCSVTNLIGRYIGHTGPKVIDQFERGLGKVLFIDEAYRLVGDSFHQDAVGEIVDAMTNPRYAHNMIIILAGYSTEIETLLEANPGLRSRFRTIINFPHMSPEHCLHLLSKLLAKVNISIPKLAIQPNTQENTMLIRALTQLTATKGWASGRDIETLSEKIAGHVFTKVGESDNVYEPGTLQVSFEELMDSLGAMVKERGAIWTTEGKNYLEQTKRQQRSSTIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DIZ1</accession>
    <accession>A0A0E0S608</accession>
    <name>A0A098DIZ1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG04015.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T14261</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DIZ1"/>
    <dbReference type="STRING" id="229533.A0A098DIZ1"/>
    <dbReference type="EnsemblFungi" id="CEF78933">
        <property type="protein sequence ID" value="CEF78933"/>
        <property type="gene ID" value="FGRRES_04015"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14261"/>
    <dbReference type="eggNOG" id="ENOG502SQEJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DIZ1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF78933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="521" mass="55184" checksum="A4571EA0D6DF47BA" modified="2015-01-07" version="1">MVQSLRDEHNKDKEKRSKWKLFSSSKDKEKRKSQDIQLPPAVTSSSAAAAAAAAEAAETSGDSTYGSSEPNHSLTTDGGDLNNTRSNVNSTGLSPGKTPDATTPTPNPNTNNNSYPNNSGPESWTSPTIKRETVTNPNTGQTITTTTTTTTTTTTITNSNGTTSTIEEPRPVMELPTVANDDVTPVSPHPPPQQQPPVLQPQSESLQPQYQPPVQAPPQAPPPAPPAPVFVSVPKTTPAPVEPSPITPTARRKSLETPGRRIIPPRDPIPSQASVSSSIPPSVPQSVPPSIPPSLAPSAADNRTSPAIPERNARRSAEFVPAPLQIGQGAFPPPPPPQDSSKPVNYSRPASKSTFANLKTAAAGIHGAGETLRGTLNSTVDKHFGGTPAAIEKNQAAIEAGRYEIEKGKFYNPNQYRLSRPHEDNGPSSDAPPIPDAQYDDPPFNMGNTTGSPAVTENDRERRRSRLGSFFGKSTGRASSQPGADPMTPRAERQKLKKRSSSGPGTPKLSVVGERLKYASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DJI2</accession>
    <accession>A0A0E0S537</accession>
    <name>A0A098DJI2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T13619</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DJI2"/>
    <dbReference type="EnsemblFungi" id="CEF78612">
        <property type="protein sequence ID" value="CEF78612"/>
        <property type="gene ID" value="FGRRES_16210"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13619"/>
    <dbReference type="InParanoid" id="A0A098DJI2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010018685" evidence="1">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF78612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="86" mass="10199" checksum="78D979F28BE70055" modified="2015-01-07" version="1">MNGIKCCDILLLILLSYAHWNTGRDTMTKIGNLDAFFFTNYTYNNTRASYYFIYLILPISQGYIHQHVINIFKRNNAFYHLSHIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DM63</accession>
    <accession>A0A0E0S957</accession>
    <name>A0A098DM63_GIBZE</name>
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        <submittedName>
            <fullName evidence="9">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FGRAMPH1_01T23459</name>
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    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF82970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DM63"/>
    <dbReference type="STRING" id="229533.A0A098DM63"/>
    <dbReference type="EnsemblFungi" id="CEF82970">
        <property type="protein sequence ID" value="CEF82970"/>
        <property type="gene ID" value="FGRRES_06902_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23459"/>
    <dbReference type="eggNOG" id="ENOG502QPW5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DM63"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="RBD_domain_sf"/>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF62">
        <property type="entry name" value="SERINE_ARGININE (SR)-TYPE SHUTTLING MRNA BINDING PROTEIN NPL3"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="249"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="358"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="362"/>
            <end position="397"/>
        </location>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG09613.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T26669</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DR13"/>
    <dbReference type="FunCoup" id="A0A098DR13">
        <property type="interactions" value="818"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A098DR13"/>
    <dbReference type="EnsemblFungi" id="CEF84286">
        <property type="protein sequence ID" value="CEF84286"/>
        <property type="gene ID" value="FGRRES_09613_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26669"/>
    <dbReference type="eggNOG" id="KOG2099">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DR13"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000002">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000003">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF84286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="885" mass="100674" checksum="BB87426D62C10204" modified="2015-01-07" version="1">MATEQQRLPTRERRPSTSAPIVDIQGAVGPTGISRPKHTRTATGFGPSEIKNFEASIPEPQREAWKRNQSRGFTGKDGFEQEVVRHVETTLARSVLNCDENAAYAATSLAFRDRLILDWNRTQQRQTYRDSKRVYYFSLEFLMGRALDNAMLNVGQKDIAKAGLSELGFRIEDIITQENDAALGNGGLGRLAACFLDSLASLNYPAWGYGLRYRYGIFKQEIVDGYQVEVPDYWLDFNPWEFPRHDVVVDIQFFGHVRKTTDSNGKSVAIWEGGEIVQAVAYDVPIPGYDTPTTNNLRLWSSKASGGEFDFQKFNNGDYESSVADQQRAETISAVLYPNDNLDRGKELRLKQQYFWVAASLYDIVRRFKKSSRPWREFPDQVAIQLNDTHPTLAIVELQRILIDIEHLEWDLAWDIVVKTFSYTNHTVLPEALEKWPVGLIQHLLPRHLQIIYDINLFFLQKVEKAFPNDRDILSRVSIIEESQTKMVRMAFLAIVGSHKVNGVAELHSDLIKTTIFKDFVEIYGPDKFINVTNGITPRRWLHQANPRLSELIASKVGGNGFLKDLTNLNQLEKYAEDKEFRKEWSEIKYANKVRLAKLIKSLVGVTVNPSALFDVQVKRIHEYKRQQLNIFGVIHRYLYLKSLTPEERKKVVPRVSIFGGKAAPGYWMAKQIIHLVNAVGSVVNNDEDIGDLLKVIFLPDYNVSKAEIITPASDLSEHISTAGTEASGTSNMKFVLNGGLIIGTCDGANIEITREIGENNIFLFGNLAEDVEDLRHNHQYGSHEIDPDLQKVFAEIEKGTFGSVHDFSALVAAVRDHGDYYLVSDDFHSYNETHKLVDEAYQNQEEWIKKTITSVSRMGFFSSDRCIDEYAESIWNTEPLVIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DTR2</accession>
    <accession>A0A0E0SE84</accession>
    <name>A0A098DTR2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T25117</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
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                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
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                <person name="Park J."/>
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                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="229533.A0A098DTR2"/>
    <dbReference type="EnsemblFungi" id="CEF84747">
        <property type="protein sequence ID" value="CEF84747"/>
        <property type="gene ID" value="FGRRES_20373"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25117"/>
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    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:oxidoreductase activity"/>
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        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
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        <property type="entry name" value="Clavaminate synthase-like"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="228" mass="26499" checksum="47B6A97605A7B433" modified="2015-01-07" version="1">MEELQIKPSGIFMQQGFVTPEHEQKLVHIFENELEWPTRPGRLSLHYGYTFSYKTFGIDEETPFKPFPDWLVPLLPTTEGRPPDQVCLQQYAPGTGIPPHVDTHGPFDQLYSLSLGSALMMQFANKEKGEKIEVDLLPRSMMQMSGDSRLHWTHGIKSRKTDTLPDGTVRLRQLRWSLTYRWLRPGAECECGNEKLCDTAQRRNGVEREYRWKQYEEDAKKDEKVKAV</sequence>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
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                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DX66"/>
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        <property type="protein sequence ID" value="CEF86445"/>
        <property type="gene ID" value="FGRRES_15319"/>
    </dbReference>
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        <property type="component" value="Chromosome 3"/>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF86445.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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    <sequence length="40" mass="4466" checksum="E0699A15703AA2C3" modified="2015-01-07" version="1">MRRIRSAGLQTVVLIFGLQAILMLLILGPKTWKANFSATH</sequence>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
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                <person name="Trail F."/>
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                <person name="Baker S.E."/>
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                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
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                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
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                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
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                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
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                <person name="Mauceli E.W."/>
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                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
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                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
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                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
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                <person name="Wapinski I."/>
                <person name="Yoder O."/>
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    </reference>
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        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        <citation type="submission" date="2017-01" db="UniProtKB">
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                <consortium name="EnsemblFungi"/>
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        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
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                <person name="Ma L.-J."/>
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                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
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                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
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                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
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            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
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    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Goswami R.S."/>
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                <person name="Harris L.J."/>
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                <person name="Kennell J.C."/>
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                <person name="Magnuson J.K."/>
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                <person name="Mauceli E.W."/>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
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                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0S868"/>
    <dbReference type="EnsemblFungi" id="CEF79693">
        <property type="protein sequence ID" value="CEF79693"/>
        <property type="gene ID" value="FGRRES_12209_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15789"/>
    <dbReference type="InParanoid" id="A0A0E0S868"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF79693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="52" mass="5485" checksum="B43D42FDA04270C7" modified="2016-04-13" version="1">MAVAQDSQLVNQGYGACKSCGCNVFGNSNGGTDKNVACVCTHKYGKRISDFH</sequence>
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            <fullName evidence="8">Chromosome 4, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SC15"/>
    <dbReference type="STRING" id="229533.A0A0E0SC15"/>
    <dbReference type="EnsemblFungi" id="CEF83978">
        <property type="protein sequence ID" value="CEF83978"/>
        <property type="gene ID" value="FGRRES_17256"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26501"/>
    <dbReference type="eggNOG" id="ENOG502QTGV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0SC15"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF05462">
        <property type="entry name" value="Dicty_CAR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="26"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="397"/>
            <end position="421"/>
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    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
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            <begin position="20"/>
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            <begin position="225"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF83978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="487" mass="54645" checksum="2610CBEC466FD22A" modified="2016-04-13" version="1">MESMGHPQGQTLTPDQINVLIAIERFGAGCSMVAIIFLLLSFALFKKLRTTPNLFLVFASIANAGASVASMIGYDGLEAGESSHLCQAQAFIFEWFMQSDPWWSLAMAINVFLVFFCNADPRMFRSYAWLYCIICFGGPLIPAIVLISIRNSPRGLMFGDATLWCWIGTDWSLVRLYAYYIPIWIFSFLSIMIYIAVGYHVFHARNMLRDLVVDGMKVGRSDSIPYSSSEHRGSSEAVAPPHDISESGDTDSYPQNLTGRQEFYGTAVTEVQIIREEPRQATHHGLAQPATAHAGSNPPRIQSWVLPGSFEQLERTTSGRAQRFETVCTSDSTPQPSSTLITRLRAIKSNASLKLKRLDPVKMAYLRTSFIFGFAVLITWIPSSINRLYSLTHGDRISFSLSVASGCVLPLQGFWNTLIYFTTSWKVFREEVRTAKAEWFKRPEECTDGIRLNSRLGTFKGDYRDTLERTRPVRAGSTEDAEKSVTE</sequence>
</entry>
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            <fullName evidence="2">Chromosome 4, complete genome</fullName>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
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        <property type="gene ID" value="FGRRES_20404"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27845"/>
    <dbReference type="InParanoid" id="A0A0E0SCP1"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF84204.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
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            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
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    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
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    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0E0SDY2"/>
    <dbReference type="STRING" id="229533.A0A0E0SDY2"/>
    <dbReference type="EnsemblFungi" id="CEF84645">
        <property type="protein sequence ID" value="CEF84645"/>
        <property type="gene ID" value="FGRRES_17232"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26843"/>
    <dbReference type="InParanoid" id="A0A0E0SDY2"/>
    <dbReference type="Proteomes" id="UP000070720">
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        <property type="entry name" value="Meiosis_regulatory"/>
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    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
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    <dbReference type="PANTHER" id="PTHR28094">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094:SF1">
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SI55"/>
    <dbReference type="EnsemblFungi" id="CEF86118">
        <property type="protein sequence ID" value="CEF86118"/>
        <property type="gene ID" value="FGRRES_16418"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16365"/>
    <dbReference type="eggNOG" id="ENOG502SKRZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0SI55"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF14">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="20"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="388"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF86118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="535" mass="59966" checksum="2AE993FE5548A53B" modified="2016-04-13" version="1">MSLDLTIEAVQSRIHAVTETLDRIQDNTGTASISIGVLHQGEVIYTRSRGVRDVDSGQAADPDTNYLLCSVSKAFTASCCGLLVHEGKLKWNEPMQSYIPFKNTIDPVIGQRATVQDALSHNTGLAHLDLTWLGVECEYLLKRDDLLDVVSYLPPVHDLRCGFHYNNYMFAVAGAVITQQSGQPWYEYLKERILEPLDLSRTTTNRTKLPDDNYAAPHVVLDDYSLHKQKPVDMASDDSLMGPAGAVWSCVTDMMKWAKALLTAMHSETETPLKQVSTIVSHKANITTSSIGENTYGLGFARATIPSTELGMISLNGPQREHVIGRSSQPRLVLYHNGGQSGYLTSFYLFPETNSAIVALGNSYGLGDGPDWTAQALAQAMFDLQPRVDFAEASLAKAKSEYERYDRLVAEFTQQRDQERAKSEGPHEVPLEDYVGRYHNTGLKMTLAINKDTDGTLKLIFNDVPSQQHKLTHFAWDKLGFMPASREELILREFIDWFKWDQFVLVFHRENKSQEVVAVNWAMQVGIEPLRFDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SKJ2</accession>
    <name>A0A0E0SKJ2_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG05601.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T18307</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SKJ2"/>
    <dbReference type="FunCoup" id="A0A0E0SKJ2">
        <property type="interactions" value="438"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A0E0SKJ2"/>
    <dbReference type="EnsemblFungi" id="CEF86955">
        <property type="protein sequence ID" value="CEF86955"/>
        <property type="gene ID" value="FGRRES_16508"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18307"/>
    <dbReference type="eggNOG" id="KOG3188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0SKJ2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045050">
        <property type="term" value="P:protein insertion into ER membrane by stop-transfer membrane-anchor sequence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
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    <dbReference type="InterPro" id="IPR002809">
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    <accession>A0A0E0SMB1</accession>
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            <fullName evidence="1">Chromosome 3, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SMB1"/>
    <dbReference type="EnsemblFungi" id="CEF87574">
        <property type="protein sequence ID" value="CEF87574"/>
        <property type="gene ID" value="FGRRES_20311"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21191"/>
    <dbReference type="InParanoid" id="A0A0E0SMB1"/>
    <dbReference type="Proteomes" id="UP000070720">
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        <source>
            <dbReference type="EMBL" id="CEF87574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
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    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="New Phytol." volume="198" first="821" last="835">
            <title>Characterization of the sterol 14alpha-demethylases of Fusarium graminearum identifies a novel genus-specific CYP51 function.</title>
            <authorList>
                <person name="Fan J."/>
                <person name="Urban M."/>
                <person name="Parker J.E."/>
                <person name="Brewer H.C."/>
                <person name="Kelly S.L."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Fraaije B.A."/>
                <person name="Liu X."/>
                <person name="Cools H.J."/>
            </authorList>
            <dbReference type="PubMed" id="23442154"/>
            <dbReference type="DOI" id="10.1111/nph.12193"/>
        </citation>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2014" name="Fungal Genet. Biol." volume="68" first="60" last="70">
            <title>Functional characterization of FgERG3 and FgERG5 associated with ergosterol biosynthesis, vegetative differentiation and virulence of Fusarium graminearum.</title>
            <authorList>
                <person name="Yun Y."/>
                <person name="Yin D."/>
                <person name="Dawood D.H."/>
                <person name="Liu X."/>
                <person name="Chen Y."/>
                <person name="Ma Z."/>
            </authorList>
            <dbReference type="PubMed" id="24785759"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2014.04.010"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="2 5 8">C-5 sterol desaturase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:24785759). ERG3A and ERG3BB catalyze the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methylfecosterol. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum. The C-8 sterol isomerase ERG2 then catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturases ERG3A and ERG3BB then catalyze the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturases ERG5A and ERG5B further convert 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>episterol + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = 5-dehydroepisterol + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:46560"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:23929"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:52972"/>
            <dbReference type="EC" id="1.14.19.20"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:46561"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The histidine box domains may contain the active site and/or be involved in metal ion binding.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4 5">Leads to a severe decrease in ergosterol production and virulence when ERG3A is also deleted (PubMed:23442154). Results in increased production of deoxynivalenol (DON) (PubMed:24785759).</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="4">In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sterol desaturase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.20" evidence="8"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SNE8"/>
    <dbReference type="STRING" id="229533.A0A0E0SNE8"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T16829">
        <property type="protein sequence ID" value="FGRAMPH1_01T16829-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G16829"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16829"/>
    <dbReference type="eggNOG" id="KOG0872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0SNE8"/>
    <dbReference type="UniPathway" id="UPA00768"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050046">
        <property type="term" value="F:delta7-sterol 5(6)-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0752">Steroid biosynthesis</keyword>
    <keyword id="KW-0753">Steroid metabolism</keyword>
    <keyword id="KW-0756">Sterol biosynthesis</keyword>
    <keyword id="KW-1207">Sterol metabolism</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000454362" description="Delta(7)-sterol 5(6)-desaturase ERG3B">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="3">
        <location>
            <begin position="157"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine box-1" evidence="1">
        <location>
            <begin position="171"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine box-2" evidence="1">
        <location>
            <begin position="184"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine box-3" evidence="1">
        <location>
            <begin position="262"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P53045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q4WIX5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="23442154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="24785759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="24785759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="23442154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87961"/>
        </source>
    </evidence>
    <sequence length="323" mass="37742" checksum="A2FC2ECF5C5FD27A" modified="2016-04-13" version="1">MDAILEILDPYVFDYGYAYLFPQQTTQPSYGNSTGFAPSSASKNFDDEYSLNFGSSLPRDDIYRQSASILMIAGFGAAFIYVISAALSYYFVFDRRLEHHPRFLKNQIKQEIQSSFFAIPIIDLLTLPFFLGEVRGHSLLYTNIDEYGWSWLAISTILYMVFNDLGIYWIHRLEHHPSIYKYVHKPHHKWIVPTPWAAIAFHPVDGYVQSVPYHVFVYLCPMQKHLYMFLFVCVQIWTILIHDGDMITGHWLERFINSPAHHTLHHMYFTCNYGQYFTWADNYWGSHRAPMPELDPIHEAIRVMQEKGLADKDGNPIEKSKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SP20</accession>
    <name>A0A0E0SP20_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG05755.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T18691</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SP20"/>
    <dbReference type="STRING" id="229533.A0A0E0SP20"/>
    <dbReference type="EnsemblFungi" id="CEF88183">
        <property type="protein sequence ID" value="CEF88183"/>
        <property type="gene ID" value="FGRRES_16537"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18691"/>
    <dbReference type="InParanoid" id="A0A0E0SP20"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF9">
        <property type="entry name" value="EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF88183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="247" mass="27868" checksum="2C9B485EB9D55BE4" modified="2016-04-13" version="1">MKVVIAGSTGFVGQEVVRQALYHPLITKVVTLSRRDHELAEDLKRPEFEEKFTSVSCSDFKSYPQYVKDEISGADACIWLIGVTPAKLKQYTWEQVRMICYEYALYAADTFAKLPREGKPEPLRFIYVSGSNAERDPAKKPWILGDYCLLRGQVEKQILERAHLSDGRMQVLVTKSGMITDPDMGFVKQAFRFFSHAIVSVPSIGLVEMTAALLNQAVNGLNKETLLNAEMAEIGKKELVRMEKNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YHS3</accession>
    <name>A0A1C3YHS3_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="2">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FGRAMPH1_01T02317</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="2"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YHS3"/>
    <dbReference type="FunCoup" id="A0A1C3YHS3">
        <property type="interactions" value="1501"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YHS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02317"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YHS3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000014">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000004">
        <property type="entry name" value="Heat shock protein SSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SCB64144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="614" mass="66792" checksum="ECDC96F6E5A8659D" modified="2016-11-02" version="1">MADEVYDGAIGIDLGTTYSCVATYEGTNVEIIANEQGSFTTPSFVSFTEKERLIGEAAKNNAAMNPRNTVFDAKRLIGRRFDDPTVKKDIESWPFKIVDDNGSPKIEVEYLGENKQFSAQEISSMVLTKMKEIAETKLGKKVEKAVITVPAYFNDNQRQATKDAGSIAGLNVLRIINEPTAAAIAYGLGAGKSEKERNVLIYDLGGGTFDVSLLNIQGGVFTVKATAGDTHLGGQDFDTNLLDHCKKEFGRKTKKDLSGDARALRRLRTACERAKRTLSSGAQATIEIDSLFDGEDFTMSITRARFEDLNAKAFSGTIEPVAQVLKDAAIEKKAVDEIVLVGGSTRIPKIQKLLSEFFDGKKLEKSINPDEAVAYGAAVQAGILSGKATSAETADLLLLDVVPLSLGVAMEGNIFASVVPRGTTCPTLKKRTFTTVADNQQTVQFPVYQGERTNCEDNTSLGEFTLAPIPPMRAGEAVLECVFEVDVNGILKVTATEKTSGRSANITISNSVGKLTTDEIEKMVNEAEQFKSNDDAFQKKFEAKQQLESYIGRVEEIVSDPTLSLKLKRNQKEKIESTISDAMATLEISESTAEDLKKQELALKRLVTKAMSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YIM8</accession>
    <name>A0A1C3YIM8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FGRAMPH1_01T03265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YIM8"/>
    <dbReference type="STRING" id="229533.A0A1C3YIM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03265"/>
    <dbReference type="eggNOG" id="KOG1703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YIM8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000077">
        <property type="entry name" value="LIM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF8">
        <property type="entry name" value="PAXILLIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="576"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="672"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="735"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="139"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="403"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="498"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="498"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SCB64216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="798" mass="87991" checksum="B394D03550458105" modified="2016-11-02" version="1">MPTTARANEPKQRKVTPPSPSYMTDDQFATYLAGLRSNRVARPGGARPQPAGARPVPSRSSLHRNSTGRFTPDLASPPDSAPHTLDRKDSMSPSIAGGSVASRLSMISKKSPDYYSTSPAIPLKPSDVVPSATYMERGQRWMEKEEASSLRDAMEEMDIRKGSKSPVQETPDDDTRLYNAALDEAAELVWQHQHGTPPPRPDGPYRYKSHLRKNSYAHARTASIGPSESNFSEGEGEAGGSVRDSSVRDSRCDPEQREPVERSASKSKTYGNIGRRTPDQRRHSLKRNISGEVGRPFSEDQIWEEPENTTSKDMSFSGRASPEKLSNRFQTSTNRVRFQAPQEAEKPKPLERVEIYRNPPTRSRNPLYTSNNSSEAIVPVVEDKVERKNGMEVRSNDIRAATSMRLKDRSPNLPEPTAVSDSPGRPIVSFDANWQAPDLSTDTTPDRALPAAPSRSSSSFAQPPEKPIAIPSIVVAAESAPLPRAPTTAQIPTICVDETQSNPRGSTPSVNVPSIAVDGPPSNGGGIPAIVTPGNKSTSRPRPLPDPRTAAAGPRTAQKPRGHWSPAPGSTRRAVTICHECGFPIDGRFVALAGGNERFHPQCFSCYTCGTNLQAMEISHEPDHLRQERLDRIKRREAGEVLDEEPGKTMAEDGDERLRFFCHLDWHELFAPRCKHCQTPILGEHIVALGAHWHYGHFFCAECGDPFDHGMTHIEKDGYAWCINCQTKRTERRAPKCKKCRIAVIGQYIQALGGEWHEHCFRCAECQGSFDDGQIFTKHVPEGTIVLCTGCRAMELKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YIP3</accession>
    <name>A0A1C3YIP3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T06305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YIP3"/>
    <dbReference type="STRING" id="229533.A0A1C3YIP3"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06305"/>
    <dbReference type="eggNOG" id="ENOG502S411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YIP3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000104">
        <property type="entry name" value="Thioesterase family protein (AFU_orthologue AFUA_2G16350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050563">
        <property type="entry name" value="4-hydroxybenzoyl-CoA_TE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793">
        <property type="entry name" value="4-HYDROXYBENZOYL-COA THIOESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793:SF27">
        <property type="entry name" value="NOVEL THIOESTERASE SUPERFAMILY DOMAIN AND SAPOSIN A-TYPE DOMAIN CONTAINING PROTEIN (0610012H03RIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB64464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="157" mass="18107" checksum="9648D8D7140FBA7E" modified="2016-11-02" version="1">MSTKSSPAELKTRKRHDYRFFLEYRTRWNDNDMYDHMNNSVYNFLFDSIINAYLIDNCGLHPPSASQFGMCVHTHTDFFSSIAYPAVAELALRVNKLGRSSVTYETALFEKGVDEVKAVGEFVQVYVDRETNRPLKDGMAQTLRVELEKLVVVKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YIS5</accession>
    <name>A0A1C3YIS5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T05857</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YIS5"/>
    <dbReference type="STRING" id="229533.A0A1C3YIS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05857"/>
    <dbReference type="eggNOG" id="KOG2024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YIS5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF4">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="6">
        <location>
            <begin position="108"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="4">
        <location>
            <begin position="311"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="5">
        <location>
            <begin position="407"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SCB64422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="686" mass="77560" checksum="7BE4DE08F0584877" modified="2016-11-02" version="1">MTYPRPDFERNPLRWESLNGQWDFLFDDGDAGLSENWQRSGLPEEVKVTTSTTSRKEGGQDSVVQKIMGEAHSLIQNNVFTSSTQTSNSKTKINVPYVFQSPASGINDRGVHEVLWYERAISDLRSAQEKEKNHRLVLRFGAVDYEATVWINGEYVGGHRGGHVPFEIDITDAVNAAKDATTHRVTIRVYDSAYDLTQLRGKQYWAAKPETIFYTPSGGIWQSVWLEVVPSARIADSSFGTVIKSNDIHSGQLRNTIVTKGRRIGKDYSVEIEARFAGIRVSKSEKKALPRESNSVGVELNVRLSEEQRSKLPKSFLESAPLENDFAWRDGVALWSPEHPQLYDLVIRLYDDKETIIDEVQTTTGMRSINWTTGDGTWRLNDKPYFQALCLDQGYWPETFMTPPSSESLKLDIELAKKMGLNGCRKHQKVEDPLFYYWADKLGFLVWGEIANAYAFSAEYIDRFNAEWTEAVKLVINRPSVVTWTPVNESWAYPSLEDNADQRNHIRQLYYLTKNLDDTRSINDNCGWQHVLTDLTTFHDYSDGPEIEKTCSTLEGIISPKADGRGVFLEPIPGVDEGSAHKPGAPVMNTEFGGVNIAPAKKEEGKDLDWGYTTATNPDDLVKRIERLVNGIVLGGHCCAFVYTQLADIEQEVNGLYTFNREEKLDASKVKAVLDKAIGQYYNRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJK0</accession>
    <name>A0A1C3YJK0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T07499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07499"/>
    <dbReference type="InParanoid" id="A0A1C3YJK0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990879">
        <property type="term" value="C:CST complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024222">
        <property type="entry name" value="Ten1_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12658">
        <property type="entry name" value="Ten1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SCB64570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="130" mass="14274" checksum="4313902E4E6EE80C" modified="2016-11-02" version="1">MSRGPVPSQLHLLSDLPAVPVGNKVRFLGCVTSYSTSSARLTLGHLYPKDSTVTASVDVSLLLQSLTNEKTRVGEYVNVIGYVTEQKTIRHKKPPYQESKQVGVQAIVLWSTGPMDLQKYEKLLSPHNGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJR1</accession>
    <name>A0A1C3YJR1_GIBZE</name>
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        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T08267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJR1"/>
    <dbReference type="STRING" id="229533.A0A1C3YJR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08267"/>
    <dbReference type="eggNOG" id="KOG0281">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJR1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="85"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="326"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="367"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="491"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="618"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="720"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="818"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="825"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="856"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SCB64620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="948" mass="104392" checksum="06932699E1AAD694" modified="2016-11-02" version="1">MDPFSPAHQPDEGYSEDPLTPTVNQELSTALATLRSPSDLSSWLVTNSSLLPLQVRTELTMALLDNLPTSVIAEIVHRLNPRLYIDFIQYLPAEICLKILGFLDPVSLVGVTQTCRAWYELALDRKLWERLYYMEGWKTILSEIEACETKVNNGLDYSIRQLSRMQSTQDAHPNKIRAVVNPDEDLEMTDRDRTPGPSEALSGGSMFGSPSSSFSSSRPAIVPMGEMDLDGLNSRTASLDRTLSSSSDSRGKRKEPSGEPESSVAPMSLADAANTLPPSPLYIWDVGRSRYRINWRYLYSMRRKLEANWELGKYSTFQFPHPSFPEEGHQECVYALQFDKDYLVSGSRDQTMRIWNVHTRRLVRPPLTGHMGSVLCLQFDADPEEDLLVSGSSDSNVFIWKFSTGELVQRLTRAHHESVLNVRFDKRILVTSSKDKTIKIFNRRPLKHGDLGYGGSDIVGPVPTNLRRYGYEPDLAQELPVKPPFTMIGRLDGHSAAVNAIQVRDRTIVSVSGDRHIKVWKWPEQVCTQTIPAHDKGIACVEFDGRRIVSGSSDWEVCIFDAPTGLKVAQLRGHAHLVRTVQAGFGDLPYSTAEDEAEAKAVDAEYFRALEAGEIDHSLDRRRRRDRRANAGSSRPEDVQAFGAKVPPGGGGGRKYGRIVSGSYDQSIIIWRRDKEGVWKPAHHLRQEEAAAAAQREAAAALSSATSNVAVAASLASRSSHASTIVPRSPPTNGTPLGPLMLRDHHGDTHRTASSYEVLIDQTVPLGPTALQQVLATYPIVLAHHTYLQSIIERETSPLVRAQLRGVVTDALANLHTRQAPLRHQSSSSSSQQTSTDSVRTNPRSSIGVPPISTMPVPTNVPAVQPPAAANANGQGAPPGQPGQAQNAAVGHHPHIAAAENTSARVFKLQFDAHKIICCSQTPTIVGWDFCNKDPALEQAVRFFATVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YL60</accession>
    <name>A0A1C3YL60_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T25209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YL60"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25209"/>
    <dbReference type="eggNOG" id="ENOG502S69E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YL60"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF44">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SCB65292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="498" mass="56295" checksum="C94351ED41B2D059" modified="2016-11-02" version="1">MARSRGGCLNCKARKRKCDQGRPECQACSQRGMRCQGYSTPLRWVNGVASRGRFAGASIPDASFVPPSTLPYPQQQQQQQQQLPQYAPSTADSNPDMSMDSENSLSTVSNHNPSSTESSSAFSPRSATGVPDPSDRIFKRFMRNGLNFLYTTEASSWIKPFFEEMALQSPALVMIAGAIQGYMDDGMSVKSMEYVDLALQTFRQELTTRYEKFHVATVCAGLLVCSLCLLQAKEWTMYLELMVNVYDLRNKLKTPGQIPIDNLYHQHILEVLGVMDMPSMVIGRAGPPIGVWKLLRRLQEDTQDGRADGIEVVSGVPRSLLDIFAGIVDHDPEYTESRFWSWPGDIGESLQIHYWDSWKLAGILEVRRRQRMNRKARGIPERDDDTPKNYPSTEIVMCRLIASIDALLKAYEEPRNQHLLVHNGLTYPVLNAGLEVPLLKLHPKWKRTMDDVKESFVTDTVDLLKVMFELIDAAWEDGTSTFDIEKVARERNIELAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLD6</accession>
    <name>A0A1C3YLD6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FGRAMPH1_01T26137</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YLD6"/>
    <dbReference type="FunCoup" id="A0A1C3YLD6">
        <property type="interactions" value="739"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YLD6"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26137"/>
    <dbReference type="eggNOG" id="KOG0760">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YLD6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF4">
        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="22"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="137"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="230"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SCB65355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="329" mass="35864" checksum="F49DA6D555CCBE8C" modified="2016-11-02" version="1">MAQPSAEPVEEEYDYESLPPNFSLLQNMAAGAFAGIAEHTAMYPIDAIKVRPPLQSHKFINSLTRFKTRMQILNSSNTPAYSGVIRNTVQIARTEGFFSLWRGMSSVIVGAGPAHAVYFATYEAVKHAMGGNQAGVHHPLAAATSGAAATIASDAFMNPFDVIKQRMQIQNSSKMYRSMFDCAKYVYRSEGLGAFYISYPTTLSMTVPFTALQFLAYESISTAMNPAKTYDPMTHCLAGAVAGGFAAGLTTPMDVIKTMLQTRGTSTDPQVRNVNSFIGGCRLLYQRAGVSGFFKGVRPRIVTTMPSTAICWSAYEFSKSYFIKRNDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLF2</accession>
    <name>A0A1C3YLF2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T26231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YLF2"/>
    <dbReference type="FunCoup" id="A0A1C3YLF2">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YLF2"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26231"/>
    <dbReference type="eggNOG" id="KOG2816">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YLF2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF40">
        <property type="entry name" value="TETRACYCLINE-EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="550"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="557"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SCB65366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="581" mass="63443" checksum="F06A390100BF44C2" modified="2016-11-02" version="1">MAKNDNIHEEETAIANEATHLLPSSSASQDEISETSSITPAWDGLKDFEGLPWWRQPSVYWLLGPYVIFTLAFGGVVVPKLDLILDLVCRQYFADQHSHNPDKVFMPVLLGTDNPQCQIPEVSANSAKFLLVMGLFTGVLSAFVTPKIGHLSDRYGRTRLMALASVGGVLNEFITILVARYPDVIDYRWLLLGSIFDGMTGSFTTGSIMSQSYASDCTPPSKRAVSMGYIHACLFAGLAFGPLLGGYFVKWTGSLLSIFYVVMGCHFAFMLFVWLVVPESLSGRRQLIAREKHEKEKEMRSQTSSSWVATLQNANPFAPLKILRPTGPGTSPALRRNLIALAIDDTIILGASMSAGAVIVLYCGLVWHWDTLEKSKFVSLISFVRVVILMGIFPIVNYFGRTRPAARRRRESGAAAVEKNNGADELDIIVLRVALVSDVVGSLGYVFAHSSGVFVASGMVTALGGLGSATGQAIITKHVPSERVGQLLGAIGMLHALARVFGPVLFNGVYALTAGRFDQAIFVLLASFFGIALTMSFTIKPHVVWEDQPEEERQPLYPTNGTLTLSSDQVPIDEEDQLRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YM54</accession>
    <name>A0A1C3YM54_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T28153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YM54"/>
    <dbReference type="STRING" id="229533.A0A1C3YM54"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G28153"/>
    <dbReference type="eggNOG" id="ENOG502SAYM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YM54"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="156"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="576"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="770"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB65534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="815" mass="90567" checksum="EF36B9A25967B1A6" modified="2016-11-02" version="1">MDNFYHPASLGHYSAPVNIPQHRLAPSRSNLSLQATIRHTADQGPVHTSKTWTNSSGDHNILNDTDELDDRANFVQEYNRLAKKNGVRILVIDDFDFRGKGFNSPRKQGWLYRILRSSSNQNGPDTLPPTQGPRHKRSVSDLAHNLVHRRETPKMIDLQSMIRISGKSMFYLPVEHAPSALILPTCLRATAHHIAQHVTTRGIFRIPGSIRVVNMLFDYYCSTEYGQVDVTSTTVRCANLPMHVQASVHDVASTFKRLLSVIPGGILGSLSLFDAFVAIHSQLQGDPEFPRTKHTKVRARLIALAIATVESQFRRELICAVFGLLSLIGRVAEITPREDEEGRPLPTGDLMGYNALGIVFGPLLLGDLLGLYSMKLATPKAGLLVLPLRSPRSRQDRRIRKTLDELQGPPTMDKILVANSITEMLIVNWRDVVRQMKSLGMNQHHEPRTVSPRGDTQENNFIIKKPQGWDREWRDQVGDEITRETSPEPPTPTLGISKHRSRNRGSSASRKLGIRPSVGCLSPTVEESILDEEGPQDAQNYKRHSVAFGSYSQQTTPRDELQDFQNEMRYSRDSHSPSVGPGKGSKSCIAPTPTSAMKSRRGIHCNSPRLSEEDVPPRTSSKQSTPLHRASANAQDVLGVTATGDPTSIERKGAIRKKHPEKGNRRHSIAVDWPESAVRSSDISTDKPEQAIQFEFLSEKEALEAAIKAHFDELRELDSSEQNRHASLDAGGNQNLPKSNLGLKTDIQQNPLDRPDGNNEYTISWGGQKTTHNNSSANSASTTPRQFYAPMQVPSTLARENLLIKSQSPDSHLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YM86</accession>
    <name>A0A1C3YM86_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <ecNumber evidence="3">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FGRAMPH1_01T10353</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>oxaloacetate + ATP = phosphoenolpyruvate + ADP + CO2</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="3"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YM86"/>
    <dbReference type="FunCoup" id="A0A1C3YM86">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YM86"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10353"/>
    <dbReference type="eggNOG" id="ENOG502QQI5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YM86"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.8.10:FF:000001">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000002">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [ATP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006820">
        <property type="entry name" value="PRK09344.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006821">
        <property type="entry name" value="PRK09344.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SCB65630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="590" mass="65261" checksum="9B46BAC3B5CB4FE2" modified="2016-11-02" version="1">MNDPVFKTASLYSNPTFIKGPGSNIQASGTDFFKMLPNNVNKTSLHPTGVTPHQEHTELEQELHDKAHIDYDRVAIIPNPSVAALYEDALVYETGTAITSSGALTAYSGAKTGRSPLDKRIVEEASSKDNIWWGPVNKPMTPEVWKINRERAVDYLNTRSRIYVIDGFAGWDEKYRIKVRVICARAYHALFMRNMLIRPTREELNDFHPDYTIYNAGKFPANRYTEGMTSGTSVAINFEQKEMVILGTEYAGEMKKGVFTVLFYEMPIKHNVLTLHSSANEGKNGDVTLFFGLSGTGKTTLSADPNRALIGDDEHCWSDNGVFNIEGGCYAKTIGLSAEKEPDIYGAIRYGSVLENVVFDPLTREVDYDDATLTENTRCAYPIEYISNAKIPCLSPNSPSNIILLTCDARGVLPPISKLDSAQTMFHFISGYTSKMAGTEDGVTEPQATFSSCFAQPFLALHPMKYAKMLADKIETHKANAWLLNTGWVGAGFAQGGKRCPLKYTRAILDAIHSGDLANVEYENYGVFNLQVPKSCPNVPSELLNPSKAWTAGEDSFNTEVVKLGKLFRENFAKYESEATEDVVKAGPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMC7</accession>
    <name>A0A1C3YMC7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T10099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YMC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10099"/>
    <dbReference type="eggNOG" id="ENOG502QU23">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YMC7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053216">
        <property type="entry name" value="Appressorial_penetr-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008687590" evidence="2">
        <location>
            <begin position="20"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB65609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="487" mass="47179" checksum="F574F6B118410A63" modified="2016-11-02" version="1">MQLKGVMVALLSMSVIADAAVVQRRHPLARALQRRQFGGGGGGNNGGNNGGNNGGNNGGNNGGNGGNNGGNNGGNNGGGGGNTLQGNAVQTGSQQDGNQPGSDEQAASATDDNNFINFCAGQTLTNGEQNRDGSCNGIPMGKIPAANKMVSSVFTSPQNGDNIQANQNFDISVQFINFAPGSFTNATNTYYSAPQDLDGGGNIIGHTHVTVQDTGNDLNPKQPLDPSVFAFFKGINDAGNGQGLLTASVEGGLPDGNYRICSMSAASNHQPVLMPVAQRGAQDDCIRITVGGNGGGGGGNNGGNNNGGQDGGQGGQGGQGGDQNNGQGGDQNGGQGGQGGQGGDQNNGQGGDQNGGQGGDQGGQGGDQNAGQGGDQNGGQGGDQNADQNAGDQGGDQNAGQGGDQNAGDQGGDQNAGQGGDQNAGDQGGDQNAGQGGDQNGGQGGQGGQGGQGGQGGGRFGRGGRGRFGGFNAASTDGAANSTTTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMN8</accession>
    <name>A0A1C3YMN8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T12383</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YMN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12383"/>
    <dbReference type="eggNOG" id="ENOG502S9TN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YMN8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039970">
        <property type="entry name" value="TF_Grauzone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225:SF2">
        <property type="entry name" value="AT09679P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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        <location>
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            <end position="205"/>
        </location>
    </feature>
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            <begin position="247"/>
            <end position="277"/>
        </location>
    </feature>
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            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
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            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <end position="259"/>
        </location>
    </feature>
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        <location>
            <begin position="260"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SCB65772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1R9C8</accession>
    <name>I1R9C8_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF71900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315657.1">
        <property type="nucleotide sequence ID" value="XM_011317355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1R9C8"/>
    <dbReference type="SMR" id="I1R9C8"/>
    <dbReference type="EnsemblFungi" id="CEF71900">
        <property type="protein sequence ID" value="CEF71900"/>
        <property type="gene ID" value="FGRRES_00062"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00062"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00201"/>
    <dbReference type="eggNOG" id="ENOG502TE02">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123452_0_0_1"/>
    <dbReference type="InParanoid" id="I1R9C8"/>
    <dbReference type="OrthoDB" id="4177994at2759"/>
    <dbReference type="PHI-base" id="PHI:8668"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.430.10">
        <property type="entry name" value="Killer Toxin P4, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015131">
        <property type="entry name" value="Killer_tox_Kp4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011329">
        <property type="entry name" value="Killer_tox_Kp4/SMK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09044">
        <property type="entry name" value="Kp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55221">
        <property type="entry name" value="Yeast killer toxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124004" evidence="1">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Killer toxin Kp4" evidence="2">
        <location>
            <begin position="10"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF71900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF71900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="133" mass="13786" checksum="85B80333AE70EDF4" modified="2012-06-13" version="1">MHFSTSILIFTSTVAGLGINCRGSGFCDLTFGSSIGDIQDQIGILVADGQGDRHFDTGAQIACTQGNQGSICAFYQSGASGSARDAFGHIQQIIDHGCSLCGSVPTQEGNNVDDGQLTVNYVSDPCCEGNCHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1R9Z9</accession>
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        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">FG00316.1</name>
        <name evidence="17" type="ORF">FGRAMPH1_01T00839</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315965.1">
        <property type="nucleotide sequence ID" value="XM_011317663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1R9Z9"/>
    <dbReference type="SMR" id="I1R9Z9"/>
    <dbReference type="STRING" id="229533.I1R9Z9"/>
    <dbReference type="EnsemblFungi" id="CEF72222">
        <property type="protein sequence ID" value="CEF72222"/>
        <property type="gene ID" value="FGRRES_00316"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00316"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00839"/>
    <dbReference type="eggNOG" id="KOG4628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008264_1_1_1"/>
    <dbReference type="InParanoid" id="I1R9Z9"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977">
        <property type="entry name" value="TARGET OF ERK KINASE MPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124033" description="RING-type E3 ubiquitin transferase" evidence="15">
        <location>
            <begin position="30"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="353"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="297"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="403"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CEF72222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="520" mass="56309" checksum="E8F328488D7AECD1" modified="2012-06-13" version="1">MKSSTIPRVGRIALLLSILACTFTTTVYADDNDISTWAETEVPDWATANAMQLSLSASGLQFAVIPLTPNLGLNDTTGRVIKIVDFDGDMIATDSSNYNKINKQDDIAYLSCDEPKDNSFLSPNKMLNTLMQTKPHIKAIVLYSRSSTWCALSQAVDLPFTSILSMADGGEATQALNLLNGTSTGKIVKANIFGNNTDNTLPKDETKGGHNTAAMSILYAITGLITLLFLAIITTGAVRAHRYPERYGPRGALGGRPRQSRAKGLARAVLDTIPIVKFGNQTPPKPDPELELENAEAHDAATQRTTSHVDDTQRSDAATAATVAARDTDAVSAAARTSSSPEGAGEETSGQQCSICTEDFKVGEDVRVLPCKHQFHPACIDPWLINVSGTCPLCRYDLRPGKGAAPEEGDAGDSSSLPPPLVLEEGAENDAPQSSHRNRLSRLFDINRLREGTVEEQMDALRRMRTVANENEHQERASVGEAIDGESRGQSARFAARLRDKFRIRTRAQAMENEDDQRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>I1RA36</accession>
    <name>I1RA36_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FGRAMPH1_01T00945</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in splicing regulation. Facilitates post-transcriptional gene silencing (PTGS) by limiting the degradation of transgene aberrant RNAs by the RNA quality control (RQC) machinery, thus favoring their entry into cytoplasmic siRNA bodies where they can trigger PTGS. Does not participate in the production of small RNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316016.1">
        <property type="nucleotide sequence ID" value="XM_011317714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RA36"/>
    <dbReference type="FunCoup" id="I1RA36">
        <property type="interactions" value="1093"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RA36"/>
    <dbReference type="KEGG" id="fgr:FGSG_00358"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00945"/>
    <dbReference type="eggNOG" id="KOG3428">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123956_3_0_1"/>
    <dbReference type="InParanoid" id="I1RA36"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000008">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="80"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SCB64041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="126" mass="13538" checksum="FBC4CBEA15AB8215" modified="2012-06-13" version="1">MKLVRFLMKCANETVTIELKNGTIIHGTISSVSPQMNTALRNVKMTIKGQEPISLETMNIRGSTIRYFILPDSLPLDTLLIDDAPKPKNKARKEAADRGARGGRGRGGPRGRGRGGGGGRGRGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>I1RA72</accession>
    <name>I1RA72_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">FGRAMPH1_01T01037</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316059.1">
        <property type="nucleotide sequence ID" value="XM_011317757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RA72"/>
    <dbReference type="STRING" id="229533.I1RA72"/>
    <dbReference type="KEGG" id="fgr:FGSG_00397"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01037"/>
    <dbReference type="eggNOG" id="KOG1376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015718_0_2_1"/>
    <dbReference type="InParanoid" id="I1RA72"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000006">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000011">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="50"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="249"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SCB64047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="453" mass="50483" checksum="D53CD7EF9F4AC67F" modified="2012-06-13" version="1">MKGEILHLHLGQAGTQLGNSAWELYLLEHGLGPDGRPDPNAPDIGDPGSFETFFTETNSGKYVPRSLFVDLDPSPIDEIRTGEYRNLFHPELLVSGKEDAANNYARGHYTIGKEMVDNVMDRIRRVADNCQSLQGFLIFHSFGGGTGSGFGALLLERLSTEYGKKSKLEFAVYPAPRTSTAVVEPYNAVLSTHSTIENSDCTFLVDNEAVYDICRRNLDIPRPSYEHLNRLIAQVVSSITSSLRFDGALNVDLNEFQTNLVPYPRIHYPLISYAPVISANKSEHESFKVQELTFQCFEPNNQMVVCDPRNGKYMAVALLYRGDCVPRDCNAAIASLKAKASFNLVEWCPTGFKLGINYQKPMAVPAPAEAGGLAPVKRSVSMLSNTTAIAEAWSRLDYKFDLMHSKRAFVHWYVGEGMEEGEFTEAREDLAALEKDYEEVAADSFEPEEELEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1RAM1</accession>
    <name>I1RAM1_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
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        <name evidence="3" type="primary">FG00553.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T01411</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316234.1">
        <property type="nucleotide sequence ID" value="XM_011317932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RAM1"/>
    <dbReference type="STRING" id="229533.I1RAM1"/>
    <dbReference type="EnsemblFungi" id="CEF72506">
        <property type="protein sequence ID" value="CEF72506"/>
        <property type="gene ID" value="FGRRES_00553"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00553"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01411"/>
    <dbReference type="eggNOG" id="ENOG502QWQI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023476_1_0_1"/>
    <dbReference type="InParanoid" id="I1RAM1"/>
    <dbReference type="OrthoDB" id="2534759at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702:SF1">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF72506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="533" mass="60354" checksum="E53BEEF4FC46AD5B" modified="2012-06-13" version="1">MMATTNNQTPLLRCESPPPDALPTPALGACPELSRCVSTTSSWSHGSNDANSRDSLGIENYNNRHSTGNLDVTSMKQRRDVSTSRHSSYNLDGRSRRRGYMRPQGTDFAESARSRESVMSLGSIAHLQYYFARTGLLDGKGGQLARKKQQRATLDLSSLDTNTGSLPNIAGSDVDSYASTSSSPDFSSQGFGNDIVESPTEEMEEFFDDTFSDVGGNMLPPTVSTYHHRENVVPKPPTIEELKFELEQALGDAKDALDEVEARRAGTFKPPADAPEYPNMPKEHTQGWYELQGMHILDVATLAIRAAKMYYTAHELPDRLDSIKPEKQVRADLLGVMETLRQMATRNFKEGMKEEEIKTMTNWIDSVFDILKQEQEIEDAEIAERDGWIWLKGDWTDRELERERQFLLSMDTTSEPLPEWKPMSATDEKPTPFLEAMQDGVRLVKLHNAVVHKSRRRFGAIGSYHTDTQKPYRCADNLRYWVKAAELRFEVMLKVDVLAVQYNTSPQAWVDFEAAILKWSRHVRDEVTRELEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RAN3</accession>
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        <recommendedName>
            <fullName evidence="9 10">M-phase inducer phosphatase</fullName>
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    </protein>
    <gene>
        <name evidence="14" type="primary">FG00565.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T01439</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 16">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the MPI phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2 10"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316248.1">
        <property type="nucleotide sequence ID" value="XM_011317946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RAN3"/>
    <dbReference type="STRING" id="229533.I1RAN3"/>
    <dbReference type="EnsemblFungi" id="CEF72520">
        <property type="protein sequence ID" value="CEF72520"/>
        <property type="gene ID" value="FGRRES_00565"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00565"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01439"/>
    <dbReference type="eggNOG" id="KOG3772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017900_0_0_1"/>
    <dbReference type="InParanoid" id="I1RAN3"/>
    <dbReference type="OrthoDB" id="26523at2759"/>
    <dbReference type="PHI-base" id="PHI:5697"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01530">
        <property type="entry name" value="Cdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="12">
        <location>
            <begin position="379"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="518"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF72520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="563" mass="62982" checksum="A69FB84EEF14A1F2" modified="2012-06-13" version="1">MEASSPLAALHRPSMLPSWGSRDIFRGHPHYATSSVTSASMSLREQMHKHSTGDYFNVKDVRGASPATSLAADISQNFRLDSDSSPKFHTPRRALFTAGMVRSFQDRDSLKTPPLPTSSPAPLTELKELMEISPLPHKAPFFTQFEVTSPTPGSTPAADDEMMLDSPAPISRQSSLEPPRPIMAENRRIAMPRRPSLTRMKGFSTTAVPNRQADAVDTTPFRFSAGGSRLNHTSSNLSLSECFESASPPQERRPASANSPCPGMPAGRARPQFLNFNACARNNASPSMNAHSRRQSNPFLRNRKQFRRSLSMFEHPADVMKSNSDGEETPSPALQSVMDVEEAQEPVLPHFLLEDPTDTIPRISRETLVDVLDGKYSSHFDQKIVVDCRFEYEYEGGHIDGAVNYNDKDLLTNQLFQTPMDGRTLLIFHCEYSAHRAPLMARHVRSEDRTVNAEHYPKLTYPEVYILDGGYSGFFTEHRGRCYPQEYVEMSDEAHQRTCEREMGRLKSRKGLSRAATFAFGQRERSVEESPTAPSRPSSRHPHLHASISRLGASPITRRMASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RB84</accession>
    <accession>A0A098D4C3</accession>
    <name>I1RB84_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG00792.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T01989</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316504.1">
        <property type="nucleotide sequence ID" value="XM_011318202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RB84"/>
    <dbReference type="STRING" id="229533.I1RB84"/>
    <dbReference type="EnsemblFungi" id="CEF72796">
        <property type="protein sequence ID" value="CEF72796"/>
        <property type="gene ID" value="FGRRES_00792"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00792"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01989"/>
    <dbReference type="eggNOG" id="KOG0201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021323_1_0_1"/>
    <dbReference type="InParanoid" id="I1RB84"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="PHI-base" id="PHI:1263"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF1">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE EPSILON SUBUNIT HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="319"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF72796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="623" mass="69557" checksum="044DA56F9E587F10" modified="2012-06-13" version="1">MAEPRLGLSEFISEERTEPFSQSEIDARFKGIRVEEPVPTTTSSAVSLDELHVEDHHHKQGIRILFRPLASFPNSRAVSPGSESCQWLALRAEVASPEQPEHKVLAVTQTSKDIKFSVRIPGETQDASPRPPLWCELYYDPASDKVIFLNKSDVPISLSSVVPTPLSSPPVSAAHIINPGSAKALKPGTWRITVRDIEVIDFRVLEKRPVTVFQPRQPTIPEDVPPTSSTPTINSSGKRALTPEYDEKRVKRRISEPDTPGDDGVIMFLRPSADPLVFSLPNGRESKELSTVNGHALLDAEKGDTVAIPSVCELNEYQLTKREPIASTSLSAVYTATHSHVPDNIVTVKVLKTRVANSNDKSLLHERNVIRQADMWLRECRSQEDLQHKSIVRYYGGDARFLSLYMEHIDAKDLTAAPRWRNKANDEFLGDRNDATRILCDIAGALNYIHGRKLVHNDIKPANILYSPERGAVLCDFGLSTLAANSPTTGGTPYYIPPEFIGRKQRGPASDTWALGVTMLYVLRKISFPDSRARRQHPRPLYWLIAGVNSPNTPHKQHGNGQPAIIQMRDWLTEIFDAREKLNPKDRLERIVKEMLYPNPNHRITMAKVLQELATDQVAVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RBT0</accession>
    <accession>A0A098D576</accession>
    <name>I1RBT0_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi SNAP receptor complex member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG01020.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T02559</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of several multiprotein Golgi SNARE complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GOSR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316774.1">
        <property type="nucleotide sequence ID" value="XM_011318472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RBT0"/>
    <dbReference type="FunCoup" id="I1RBT0">
        <property type="interactions" value="888"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RBT0"/>
    <dbReference type="EnsemblFungi" id="CEF73081">
        <property type="protein sequence ID" value="CEF73081"/>
        <property type="gene ID" value="FGRRES_01020"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01020"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02559"/>
    <dbReference type="eggNOG" id="KOG3208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078034_1_0_1"/>
    <dbReference type="InParanoid" id="I1RBT0"/>
    <dbReference type="OrthoDB" id="422156at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094:SF2">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027109">
        <property type="entry name" value="Golgi_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="48"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR027109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF73081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="228" mass="25901" checksum="CEE27C574A04ED8D" modified="2012-06-13" version="1">MSTPSGTGSWTSLIQQARQLEKQTDNLFHTYSQFAAAPNIPPKPTEKERETEKKLEELLEKREDVISKLVRLLDSEAALTSSAMKQNNLALFQKKLASHRKDLIRLRSNLQEARNRANLLTNVRSDIDQYRQNNPEAAEADYMLQERNRIDNSNSMADNVLSQAYAVNDNFNLQRETLASINRRITHAASQVPGINTLIGRISAKKRRDGIIMGGFVAFCFIVFFLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I1RBV5</accession>
    <accession>A0A098D3S8</accession>
    <name>I1RBV5_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG01046.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T02617</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316802.1">
        <property type="nucleotide sequence ID" value="XM_011318500.1"/>
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    <dbReference type="AlphaFoldDB" id="I1RBV5"/>
    <dbReference type="FunCoup" id="I1RBV5">
        <property type="interactions" value="617"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RBV5"/>
    <dbReference type="EnsemblFungi" id="CEF73110">
        <property type="protein sequence ID" value="CEF73110"/>
        <property type="gene ID" value="FGRRES_01046"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01046"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02617"/>
    <dbReference type="eggNOG" id="KOG2165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007149_0_0_1"/>
    <dbReference type="InParanoid" id="I1RBV5"/>
    <dbReference type="OrthoDB" id="5581181at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
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        <property type="entry name" value="ANAPC2_C"/>
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    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
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        <property type="entry name" value="Cullin_homology"/>
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    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057975">
        <property type="entry name" value="TPR_ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08672">
        <property type="entry name" value="ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25773">
        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01013">
        <property type="entry name" value="APC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="8">
        <location>
            <begin position="540"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="766"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF73110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="866" mass="97296" checksum="47852EDEE6677A06" modified="2012-06-13" version="1">MAMTASRYRARKQKVFRSVFQTDVSSPTPRSTPIATFTDQGAAFGGPHASSSQHAPPPPPPLFHETLDHADDQVRWDRAWHTVTSKIQLPTSVAVEDSFGTLPPESQEVDFSVRDSIVLLLDSARLLPEATHTEDILLWHTHQVRQHFVHHVMPLLAACASQDDQTQVLLSSISTLEAAHRQYHWGLTLIMQGCEDDASSNAAFSKFCRDLHAIIGNSLNQGLTDALTSVLRRLIHLNLGIGKRYDVSTSGLESQGDDSAARKELLGLLESLKNVGLVGEKFQVLFAEIMDASMKDFIRISYSGVWEVPEHSMTPSASISSGCLGHLSEWVENQYGRLAVEVFSRLETHIAWSDVECWKNIAIGRLATLRIQELFDIALEWPESRGGLEDLRLAVTTPQRRLQLTDAFSTALQKRLLHPGRSTSDILQTYISMIRTFHVLDHSKVLLDRVVHALQLYLCQRDDAIRIVVGGLLSNPSDADTEEGKANLAELAVLLNVASQQQRRQVEDGDLDWNDMTWVPDPVDAGVNYKRPRNEDVIGTLINALGSQDIFIKEFQLIIAERLLSDQATFLQETKVLSLLKKRFGESALQNCDVMMKDIQDSKKVDAILGRNIRQPSNDPGAPVYHSKILSRLFWPSLPKEPFTVPAPVTEMQKRYEQGFERLKTSRKLNWLDQLGSATVKLEFEDRSVELECKTYEAAVIYAFQDENNEGESGPTQRTFDGIWQQLMIDEDLLALALKFWASKRVIRDIGNRTYVVLEKLDDVNEAGDADTPDDSHDVGGGQPSPRKPKIDSKDQERRTVYWQFIVGMLTNSAPTMPLAQMLMMMKMLIPDGCPWTNEELQEFLAEKVAENKLELAGGKYRLPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RBY4</accession>
    <name>I1RBY4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG01081.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T02697</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316841.1">
        <property type="nucleotide sequence ID" value="XM_011318539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RBY4"/>
    <dbReference type="FunCoup" id="I1RBY4">
        <property type="interactions" value="1010"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RBY4"/>
    <dbReference type="EnsemblFungi" id="CEF73150">
        <property type="protein sequence ID" value="CEF73150"/>
        <property type="gene ID" value="FGRRES_01081"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01081"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02697"/>
    <dbReference type="eggNOG" id="KOG0397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061015_3_0_1"/>
    <dbReference type="InParanoid" id="I1RBY4"/>
    <dbReference type="OrthoDB" id="1734943at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="7">
        <location>
            <begin position="65"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF73150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="173" mass="19939" checksum="E8F9C0A8B1AE4432" modified="2012-06-13" version="1">MASEKANNPMRELKIQKLVLNISVGESGDRLTRAAKVLEQLSGQTPVYSKARYTVRTFGIRRNEKIAVHVTVRGPKAEEILERGLKVKEYELRKRNFSETGNFGFGISEHIDLGIKYDPSIGIYGMDFYCCMTRPGERVTRRRRTKSKIGASHRIKREETVKWFKSRFDGIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I1RC15</accession>
    <name>I1RC15_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG01116.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T02783</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316883.1">
        <property type="nucleotide sequence ID" value="XM_011318581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RC15"/>
    <dbReference type="FunCoup" id="I1RC15">
        <property type="interactions" value="499"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RC15"/>
    <dbReference type="EnsemblFungi" id="CEF73193">
        <property type="protein sequence ID" value="CEF73193"/>
        <property type="gene ID" value="FGRRES_01116"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01116"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02783"/>
    <dbReference type="eggNOG" id="KOG2905">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047858_0_2_1"/>
    <dbReference type="InParanoid" id="I1RC15"/>
    <dbReference type="OrthoDB" id="26094at2759"/>
    <dbReference type="PHI-base" id="PHI:1633"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="44"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="268"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="337"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF73193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="363" mass="41319" checksum="400DBCC21C7A9122" modified="2012-06-13" version="1">MAEPYIKQDPHIKADPDAPAAEEDLYEDAGDLEFYDKNAGAFETLYLARVPRYMWEAWYKLTERLGDDDEIQIGTLRTWTNQKPDGTSDTKLRMLLSANCPEHQTLPREYDLEVLEPNVNNHFIFSEEDLPGFKARSKARQDAAAAGIPASLLRQRQANNGSDRPTYDRKSRYQPYYRKAVPKRTKIFGKVHYDVRVEPRDIREEERLLQQKLLEADGNKSKLQIISQSAASSIVAPGSAGAVSWGGSFIKNTASTAKPKKGEVFKAARIPENQLLDLIFECFRQYQYWSMKALRQKLQQPDQYLRQVLEKIAVLNKSGRFANHYCLSDAYRDKGGAEAQEAAAEPMDDDDDDEEMEDVLPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RC36</accession>
    <name>I1RC36_GIBZE</name>
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        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
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        <name evidence="8" type="ORF">FGRAMPH1_01T02827</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_011318603.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="I1RC36">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RC36"/>
    <dbReference type="EnsemblFungi" id="CEF73215">
        <property type="protein sequence ID" value="CEF73215"/>
        <property type="gene ID" value="FGRRES_01138"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01138"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02827"/>
    <dbReference type="eggNOG" id="KOG2970">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032917_1_1_1"/>
    <dbReference type="InParanoid" id="I1RC36"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124036" description="Post-GPI attachment to proteins factor 3" evidence="7">
        <location>
            <begin position="29"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF73215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="331" mass="38752" checksum="5818491490D5EEFA" modified="2012-06-13" version="1">MATQRGRPWARIISLTVLVLTFAITVDASTGDRLPEFKDCLKVCNAENCAPNKPQTPIPVLHRLLLWNCASECDYACQHIVTGQRMATGLSVEQFYGKWPFYRFLGMQEPFSVLFSLGNLWAHWYGLKTMDQARIPKSYSMRIFYDWLAYIGIASWTFSSIFHTRDFHVTEELDYFAAGASVLYGLYYTVVRVFRLDKRTPRRRTTLRLWSLLCASLFLSHVSYLKFVRWDYTYNMAANVAAGIVQHVLWSWFSFNRYRESRRIWAAWPGFVVAWIIFAMSMELFDFPPWLGCIDAHSLWHLMTIGPTILWYNFLVKDAQDDMARSQRLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1RE00</accession>
    <accession>A0A098D7Y7</accession>
    <name>I1RE00_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">FG01870.1</name>
        <name evidence="14" type="ORF">FGRAMPH1_01T04529</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317719.1">
        <property type="nucleotide sequence ID" value="XM_011319417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RE00"/>
    <dbReference type="FunCoup" id="I1RE00">
        <property type="interactions" value="1037"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RE00"/>
    <dbReference type="EnsemblFungi" id="CEF74071">
        <property type="protein sequence ID" value="CEF74071"/>
        <property type="gene ID" value="FGRRES_01870"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01870"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04529"/>
    <dbReference type="eggNOG" id="KOG1596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059055_1_0_1"/>
    <dbReference type="InParanoid" id="I1RE00"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CEF74071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="324" mass="33811" checksum="458C7B83EC657CF3" modified="2012-06-13" version="1">MAPFTPRGGARGGRGGARGGGRGGFGGDRGGFGGGRGGARGGRGGGRGGFGDRGGRGGRGGRGGAPRGGRGGATGAKGGAKVIVEPHRHPGVFVVRGGKEDGLATRNTTPGESVYGEKRISVDEVVKNDDGTTTTTKIEYRMWNPFRSKLCAAIAGGADEIYIKPGSRVLYLGGASGTSVSHVADIVGPTGYVYAVEFSSRSGRDLITMASKRPNVVPIVEDARQPARYRMIVPMVDVIFADVAQPDQARIVAMNANWFLKVNGGVLISIKANCIDSTAPAAEVFAAEVQKMRAESIKPKFQLTLEPFERDHCLVAGEYLRYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1REE3</accession>
    <name>I1REE3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG02031.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T04905</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317903.1">
        <property type="nucleotide sequence ID" value="XM_011319601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1REE3"/>
    <dbReference type="FunCoup" id="I1REE3">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF74259">
        <property type="protein sequence ID" value="CEF74259"/>
        <property type="gene ID" value="FGRRES_02031"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02031"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04905"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_0_1"/>
    <dbReference type="InParanoid" id="I1REE3"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="82"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF74259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="479" mass="51457" checksum="5F720BB71964B449" modified="2012-06-13" version="1">MPYNEHNAEDSCLKNQHRACPAQDESINFSPSSTSPPPLVIQRGDPEKSPSAPATAPGLEYAETTSTENHEPNLDFPEGGLQAWLVVFGSFCGMFSVYGLINTAAVFESYFSENQLKDYSSSQIGWIFSLYLFMVFIVGIQVGPVFDKYGPRLIVLAGGLLIATSLFILSVCQEFYQILLSYSVVGGLGGALLNSPSYASIAHWFDVRRGLATGCAMTAGSIGGIIFPIVLQKLLPTIGFAWTTRILGFIILGLTVPATLFMRSRLPRHNKVTSVWPDLGIFRDLKFTFAAFGIFFTEWGLFVPLTYIVSYAGRYSGNPTSSYTLLSILNAGSLLGRFLPGFLADKIGRFNVMLLTLGLCIVSAFALWLPAGGSQAMIIAFAVVFGFGSGSNLGLTPVCVGQLCDPRDYGRYISTAFMVASFGTLSSLPIAGALLEAGGNGDAGWTALIVFDGLSYVLALACFLAARVLAVGWNVKSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1REN5</accession>
    <accession>A0A098D5Z6</accession>
    <name>I1REN5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG02128.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T05127</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318006.1">
        <property type="nucleotide sequence ID" value="XM_011319704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1REN5"/>
    <dbReference type="EnsemblFungi" id="CEF74369">
        <property type="protein sequence ID" value="CEF74369"/>
        <property type="gene ID" value="FGRRES_02128"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02128"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05127"/>
    <dbReference type="eggNOG" id="ENOG502SM97">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023464_1_0_1"/>
    <dbReference type="InParanoid" id="I1REN5"/>
    <dbReference type="OrthoDB" id="3728558at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046676">
        <property type="entry name" value="DUF6546"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20183">
        <property type="entry name" value="DUF6546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6546" evidence="1">
        <location>
            <begin position="197"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF74369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="410" mass="46603" checksum="CA4E312DE585314E" modified="2012-06-13" version="1">MRLRSSGFLKWSSLPPEIRHMILNTIVDLKNPRWADLASVSKEWQSVIGVRNMAKLKLQSPSCFDGFEKIVQQRHLVKHIYLCVELPKYDCTLCKARTRTPSFSRDSSIISHAIGKILSILSTWKTQGPLTLELNAVSCKSTWHDPSHGWVNGTQLCTCHCGHQPVDSSPIPPLSSTFQSGQTVVAAEREEAIGMVLPKTLKSLILFQHSVEHLTQSAYQDPSYERLRDIRNRLDIQNKSSRYLAQTSLRLEQFFVSFLINAGDFLAACRKEWTWEHLQSLALSFQGSGKHHQEGINSPLLSTAKVALRMPKLETLVLWSGDRGTTCAFIYTRNEYCAQVVWRGTWDLDISQEALKAWEAVAALYSLELRVEHERIQEVIRSCGDAIHHLNLPCQIIQPTSLWQMRVEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1RF44</accession>
    <name>I1RF44_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG02310.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T05565</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318219.1">
        <property type="nucleotide sequence ID" value="XM_011319917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RF44"/>
    <dbReference type="EnsemblFungi" id="CEF74587">
        <property type="protein sequence ID" value="CEF74587"/>
        <property type="gene ID" value="FGRRES_02310"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02310"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05565"/>
    <dbReference type="eggNOG" id="ENOG502RKGN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066482_0_0_1"/>
    <dbReference type="InParanoid" id="I1RF44"/>
    <dbReference type="OrthoDB" id="3596450at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="17"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF74587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="358" mass="41842" checksum="3291B8E01DC06017" modified="2012-06-13" version="1">MTEHLDDLSAADTPTTFQSFPKLPTEVRLRIWKHACFPRSQIDHGIHYVTVNIVHEDFEGEDIVTSDNNLEGYDEESTVESDDDGYVTLTAPKLPFDDPAGRSSNASACLWDAGLSTACHESRLAFAEYHNLKGWRELREKPINTTQTNLWYHQAYPSTLVPHKRDKNWCPMTVPLFDIFCIDMSSIKKLPKSLYSMKLLTPFLSTRTFTIRESWNIAIKYDKSWNKKLVPQEYRLKRENTPRGRLANWLDRFNDEVIPKPNVWIIDDNVEWVARGEQTYTPVYRDCDGEYVQIDWEDARRDGAKGDVTRFFERLSDVLDDEIDYVPFRTKQIVKLLVRKDNEIPRDPNKELELRSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1RG85</accession>
    <name>I1RG85_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG02741.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T06583</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318705.1">
        <property type="nucleotide sequence ID" value="XM_011320403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RG85"/>
    <dbReference type="EnsemblFungi" id="CEF75097">
        <property type="protein sequence ID" value="CEF75097"/>
        <property type="gene ID" value="FGRRES_02741"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02741"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06583"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_0_1"/>
    <dbReference type="InParanoid" id="I1RG85"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF230">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="264"/>
            <end position="289"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="309"/>
            <end position="327"/>
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    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="61"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF75097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="464" mass="49656" checksum="AC0C408DEB30BB21" modified="2012-06-13" version="1">MINSIPQDENVQRNSVQENANWAAFGLDPITATMSSINPDAEAQAQTEQETRGQDVEKSLAAWTCVLGAFLTLIPTFGFMNSLGTVQTYLSMNQLHDYSEGEVGWISGMFLFLSLILNVQVGPMVDVHGPNVIGPVGAVLYVAMFLLMAECRNYWHFMLCLGVFGSFGAAMTMVVAIAIVGKLFVRSRGLAMGITLAGSSTGAVIFPIILRSTYPNLGWQWSMRIMAFISAGLLVPSMICFIPFNNIYKKSTGGGQASPKSSTLNFTAFQSPAFCFVTGGIFMFEFVIFSISGLLPSIATRIGFTPENGYTLLAIVGAASTFGRIIPGVIGDKYGHFNILLVTVVFTIIFMGALLVPFGTRSATALYAWSALWGLGSGSFLSITPVCMGKTCEAKDYGRYYGMMNFVTAFALLIALPSSGAMLENMGPQALAGLFTALTAVGGACNFAARALLIGEWLSPKTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJM4</accession>
    <name>I1RJM4_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG04049.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T14337</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321604.1">
        <property type="nucleotide sequence ID" value="XM_011323302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJM4"/>
    <dbReference type="STRING" id="229533.I1RJM4"/>
    <dbReference type="EnsemblFungi" id="CEF78971">
        <property type="protein sequence ID" value="CEF78971"/>
        <property type="gene ID" value="FGRRES_04049"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04049"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14337"/>
    <dbReference type="eggNOG" id="ENOG502SMAU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054243_2_0_1"/>
    <dbReference type="InParanoid" id="I1RJM4"/>
    <dbReference type="OrthoDB" id="5275938at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
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        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="57"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF78971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="273" mass="31063" checksum="A2E1B27BC91CD4AB" modified="2012-06-13" version="1">MCPLNGPSDQGIPFCQLARYAWSNLNLGLIQPLKQDADHPLTKNSDQQVVEDLIPGGDLVLAVGPGRRLFGVSSNFLCEISPVFAVMFGPNFEEGHRLRSTQPEDSEMVLELPDDNAQAFSDTIRVLYGADPVTVDFEPAEIQKITIVVDKYDMIPRFTFASAYWFAKYPWTDDPEETWQLTTAAYWMQNPDAFFNYSKKLIRHMQSSHLSFVDDMPDKVLGLRLCLAIEEQRVHRLTHGTKAKGGLCLHCFSRSKVSFTLRIKGCKHRKYHY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-12-02" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>I1RL11</accession>
    <accession>A0A098DKZ3</accession>
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        <recommendedName>
            <fullName evidence="10">Non-reducing polyketide synthase dpfgA</fullName>
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        <alternativeName>
            <fullName evidence="10">Diterpenoid pyrone biosynthesis cluster protein A</fullName>
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    </protein>
    <gene>
        <name evidence="10" type="primary">dpfgA</name>
        <name evidence="11" type="synonym">PKS15</name>
        <name type="ORF">FG04588</name>
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    <organism evidence="14 15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2020" name="Nat. Commun." volume="11" first="1830" last="1830">
            <title>Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones.</title>
            <authorList>
                <person name="Tsukada K."/>
                <person name="Shinki S."/>
                <person name="Kaneko A."/>
                <person name="Murakami K."/>
                <person name="Irie K."/>
                <person name="Murai M."/>
                <person name="Miyoshi H."/>
                <person name="Dan S."/>
                <person name="Kawaji K."/>
                <person name="Hayashi H."/>
                <person name="Kodama E.N."/>
                <person name="Hori A."/>
                <person name="Salim E."/>
                <person name="Kuraishi T."/>
                <person name="Hirata N."/>
                <person name="Kanda Y."/>
                <person name="Asai T."/>
            </authorList>
            <dbReference type="PubMed" id="32286350"/>
            <dbReference type="DOI" id="10.1038/s41467-020-15664-4"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PATHWAY</scope>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2022" name="J. Fungi" volume="8" first="0" last="0">
            <title>Gramiketides, Novel Polyketide Derivatives of Fusarium graminearum, Are Produced during the Infection of Wheat.</title>
            <authorList>
                <person name="Seidl B."/>
                <person name="Rehak K."/>
                <person name="Bueschl C."/>
                <person name="Parich A."/>
                <person name="Buathong R."/>
                <person name="Wolf B."/>
                <person name="Doppler M."/>
                <person name="Mitterbauer R."/>
                <person name="Adam G."/>
                <person name="Khewkhom N."/>
                <person name="Wiesenberger G."/>
                <person name="Schuhmacher R."/>
            </authorList>
            <dbReference type="PubMed" id="36294594"/>
            <dbReference type="DOI" id="10.3390/jof8101030"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2023" name="J. Fungi" volume="9" first="0" last="0">
            <title>CRISPR-Cas9 Gene Editing and Secondary Metabolite Screening Confirm Fusarium graminearum C16 Biosynthetic Gene Cluster Products as Decalin-Containing Diterpenoid Pyrones.</title>
            <authorList>
                <person name="Hicks C."/>
                <person name="Witte T.E."/>
                <person name="Sproule A."/>
                <person name="Hermans A."/>
                <person name="Shields S.W."/>
                <person name="Colquhoun R."/>
                <person name="Blackman C."/>
                <person name="Boddy C.N."/>
                <person name="Subramaniam R."/>
                <person name="Overy D.P."/>
            </authorList>
            <dbReference type="PubMed" id="37504684"/>
            <dbReference type="DOI" id="10.3390/jof9070695"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="7 9 13">Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of diterpenoid pyrones (PubMed:32286350, PubMed:36294594, PubMed:37504684). The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpfgA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable). The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpfgD through the action of the prenyltransferase dpfgC to yield a linear alpha-pyrone diterpenoid (Probable). Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpfgE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpfgB (Probable). The short chain dehydrogenase/reductase dpfgG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpfgH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350). Higginsianin B is further methylated by the methyltransferase dpfgI to produce the intermediate named FDDP B (PubMed:32286350). The cytochrome P450 monooxygenase dfgpJ then catalyzes a three-step oxidation at C-27 to generate a carboxylic acid as well as C-26 hydroxylation (PubMed:32286350). Finally, methyltransferase dpfgK methylates the carboxylic acid generated by dpfgJ, yielding the final diterpenoid pyrones from the pathway which were named FDDP D and FDDP E (PubMed:32286350).</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Multidomain protein; including a starter unit:ACP transacylase (SAT) that selects the starter unit; a ketosynthase (KS) that catalyzes repeated decarboxylative condensation to elongate the polyketide backbone; a malonyl-CoA:ACP transacylase (MAT) that selects and transfers the extender unit malonyl-CoA; a product template (PT) domain that controls the immediate cyclization regioselectivity of the reactive polyketide backbone; a methyltransferase (CMeT) domain responsible for methylations; and an acyl-carrier protein (ACP) that serves as the tether of the growing and completed polyketide via its phosphopantetheinyl arm.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="8 9">Abolishes the production of both diterpenoid pyrones FDDP D and FDDP E.</text>
    </comment>
    <comment type="biotechnology">
        <text evidence="7">Diterpenoid pyrones display various biological activities and FDDP E shows anti-HIV activity (PubMed:32286350). FDDP D and FDDP E show also inhibitory activity of 42-mer-amyloid beta aggregation that is involved in the pathogenesis of Alzheimer's disease (PubMed:32286350).</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="13"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320993.1">
        <property type="nucleotide sequence ID" value="XM_011322691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RL11"/>
    <dbReference type="SMR" id="I1RL11"/>
    <dbReference type="STRING" id="229533.I1RL11"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T15647">
        <property type="protein sequence ID" value="FGRAMPH1_01T15647-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G15647"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04588"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15647"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_6_3_1"/>
    <dbReference type="InParanoid" id="I1RL11"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041068">
        <property type="entry name" value="HTH_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF21">
        <property type="entry name" value="NON-REDUCING POLYKETIDE SYNTHASE AUSA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18558">
        <property type="entry name" value="HTH_51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000451524" description="Non-reducing polyketide synthase dpfgA">
        <location>
            <begin position="1"/>
            <end position="2172"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="3">
        <location>
            <begin position="389"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="4">
        <location>
            <begin position="1270"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1671"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal acylcarrier protein transacylase domain (SAT)" evidence="1">
        <location>
            <begin position="74"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Malonyl-CoA:ACP transacylase (MAT) domain" evidence="1">
        <location>
            <begin position="895"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="4">
        <location>
            <begin position="1270"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Product template (PT) domain" evidence="1">
        <location>
            <begin position="1277"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="4">
        <location>
            <begin position="1428"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1608"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1650"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1751"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Methyltransferase (CMeT) domain" evidence="1">
        <location>
            <begin position="1975"/>
            <end position="2155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1650"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="3">
        <location>
            <position position="529"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="3">
        <location>
            <position position="665"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="3">
        <location>
            <position position="706"/>
        </location>
    </feature>
    <feature type="active site" description="For acyl/malonyl transferase activity" evidence="5">
        <location>
            <position position="981"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="1707"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="32286350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="36294594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="37504684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="10">
        <source>
            <dbReference type="PubMed" id="32286350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="11">
        <source>
            <dbReference type="PubMed" id="36294594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="12"/>
    <evidence type="ECO:0000305" key="13">
        <source>
            <dbReference type="PubMed" id="32286350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CEF79623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="2172" mass="238750" checksum="0A86C4496B80D70B" modified="2012-06-13" version="1">MATDSPSLLICGSVISDPDHAYLSRIRSSIIHNPHLAELQDAVIELPELWSLLVEREKSLQRVDAARVLRNLVEWIKCGNSSLPLEGRTSRNTQLAVLTVLAHFSEYMIYLNSHDMSEEDGRGNLDAHTSVLEGVRDGGIQGLCVGLLSAIALACSPTITDVAKYGTVAVRLALCVGALVDLDETELSEPTACIFARWPQSEDDDREELLKAVLENYPSSYVGVRLDVCSVNITAPKGVAMSLMRSLEETGAVAKQINLQGRYHHPGHEAMFQKLTDLCASLQMLQFPHHSHPLVPLRWNDSGEVVTDQTPLHEVALQCILVKRADWYTTITKSVTDMAQRTVASSADSKARVLALGPVDCIPRSILFITPLQVVRPMANAAFYHGYPDDSIAIIGVSCRFPGSETLPQFWEEIRAKRVNSCLEAAGSLDCAFFRKPPREAEHMDPQHRLGLHLAYEALQSGGYFSPSSSVTDNVGCYIGMSSCDYEENVNSHPPTAYSFTGTARAFSSGRISHFFGFTGPSMVIDTACSSSGVAIHTACKAIQSGECSMALAGGINLMVPEARSHQNLAAASFLSPTGQCRPFDARADGYRRSEGGGFVLLKRLSAAVADNDCILGVLAASAVNNSKGSRSITLPSIESQSHLYRRVLQAAGLHPHQVSYVEAHGTGTQKGDPIEWQSIQNVFGGRDRSGLPPLRLGSVKGNIGHCEAASGVAALVKVILMLQNRQIPPQANFSVLNPALPSLEEANMDIPVCLEPWEAPFRAAMVNNYGASGTNAAMLVCQPPLASPERLMSTGQPHQCPILIASHSESSIRQYCRTLMSFVETQRCVLGDSLLPSIAFHLGQRQNESCRHRVAFSATSADELKVRLHSQARNNHDESKASKPQGRPKPVVLVFAGQTGRQALLSREAYLSSSLLQHHLDRCDRILQTMGLHSLFPRIFETEPVDDLVDLHCMHFSLQYSVAASWIDTGLEIKAMVGHSLGQLTALCVSGVLSLRDALKMISGRASLIQNKWGSERGCMLSVEADAPTVETIAQSMPGAGKIEIACYNAALHQVIVGTEAAIAAFEEVARSRNVSVKRLLVSRGFHSEMMDCIVPEYQQLIQQLTLHPSVIPFEPCCKLGDNWDNITPELIARQSREPVYFSDAIRRVEKRLGPCIWLEAGSGSAGVTMARRALTNPGTPSFPSHSFHSILLQGQNPIKSLADTTINLWNEGIRVQFWLYHASERRRFMPLELPPSPFEKSEHWLPVLQKHKDSELANQNQDQKQEAPELVSLAGPTDGETVEFFINQHSNDYSTFVRGRTVFGQVLAPSSVYIEAVTRAFTLLPMYLSTPSSSPPSVEVKQVRMHAPFGLDLQKRLRLTLRKETMSSWRFVVESHPIDDGDNKARKIQASGTINWQGQGCAYLEPSRPLLRRLYDRCDELRDDRSASTVQGLFVKNILARVATYDNRYLGIQSITSKGLEAVADVAMPTIMSQACAGTVLSPPIFDNFLLIAELHASSLEDLAEDVYICNGFDAVIPHAHPGDMVSKCEGPWMVLSYLNRENDKTVSCDIFVTSADRDILLLEIIGASLKRIPIRSLQKALESINGIQQIQGSTARGTASTVVIDSDSDLPDSEANSPRVGSDLHADFPDLHPTYVPRISRVTSSDYPMDSSSFSSAQPPSSASSVLSDHDQESTALLSLLSEHLNCSQGIPPDTRLGEIGLDSLVAIQLKSDVEKAFGKRLSLDTIDENLTFSDLYRMVLNHDLPNDRGSTVLSDKAPKSKSDSSLHGQSYHVTPIRETTVSFQDSTLFTTQARLEFAQIKQETSSFAQMTGFAGFYTDVHQKQTSLVLAYILEAFSTLGCDLSALQAGDPLPPLRYTSKYQKLVSRFHKILEGAGLISVCEGQSVRFRTAEPLPQFGSSADTYRELLNECPKYRPDHQLLNVTGSRLSDCLSGRADPLQLLFRDAAAVKLLEDVYVSSPMFATGNKMLGEFLHRVLSRLGSTKRLRVLEVGAGTGATTRNAMDQLLASNVDFTYTFTDVSIALVTSAKKKFGALYNSQRRQSNMEFTVLDIEKSPPANMLESYDLIISSNCIHATRNLGQACANIEKLLRRDGGMLCLLELTRPLSWLDCVFGLLDGWWRFDDDRTYALADEHKWKSTLLDAGFIHVDWTDDGYRESEQFRLITAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I1RLK1</accession>
    <accession>A0A098E2Y7</accession>
    <name>I1RLK1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FGRAMPH1_01T16351</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323251.1">
        <property type="nucleotide sequence ID" value="XM_011324949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RLK1"/>
    <dbReference type="EnsemblFungi" id="CEF87458">
        <property type="protein sequence ID" value="CEF87458"/>
        <property type="gene ID" value="FGRRES_04804"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04804"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16351"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_3_1"/>
    <dbReference type="InParanoid" id="I1RLK1"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF30">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04702)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="56"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF87458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="551" mass="61054" checksum="750B722B2F35CC42" modified="2012-06-13" version="1">MDNSSSHHDDVPGTVRLIDINGMNSSGPHDSQHKDIVLVPRPSSDPEDPLNWTYHRKLLAVSMAYLYVLGTGIATSLQYSVLADITKDTGISTANLVQGTGVMFLFFGWACLIWQPIALTYGRRGVYLLTMLLTIPIMTWTAYSSSAGVWFAHRVLIGIIVSPIESLCEVTVFDLFFAHNRGTYMGLYVAILFGSNFLAPLVAGWFNDAYGWRWTMHFGAIICAVCFVIMFFFMEETMYFRGASIESQVVEDTTHTEPMKTKMNGDEESRDVGTDSQNGSQPSTTPPTTKHSINSGWGKYTWFKVLPGRPSNTDMLRMVYRPVLMIFHFPTVAWAGFLYGINLAWYNVLNGTASPVLSSKPYNWSAALVGCVYAGPIIGAAIACLWVGKAADWIALWLARRNGGIREPEQRLWVLLVSGIISSAGLVVWGVGAYYQVHWIGLVFGLGMLTVGCVAGGAIAVSYNVDCFKEIAGETTVSIMLIRNTIGFGFSYAITPWWTSQGLKNCFITAAMISLACTFTFLIMIVYGKRLRRWSIPAYRKYMTTMAVSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I1RND6</accession>
    <name>I1RND6_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exosome complex component RRP45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Ribosomal RNA-processing protein 45</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG05509.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T18095</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324056.1">
        <property type="nucleotide sequence ID" value="XM_011325754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RND6"/>
    <dbReference type="FunCoup" id="I1RND6">
        <property type="interactions" value="926"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RND6"/>
    <dbReference type="EnsemblFungi" id="CEF87868">
        <property type="protein sequence ID" value="CEF87868"/>
        <property type="gene ID" value="FGRRES_05509"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05509"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18095"/>
    <dbReference type="eggNOG" id="KOG1614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038194_0_0_1"/>
    <dbReference type="InParanoid" id="I1RND6"/>
    <dbReference type="OrthoDB" id="10264038at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11368">
        <property type="entry name" value="RNase_PH_RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000005">
        <property type="entry name" value="Exosome complex component RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033100">
        <property type="entry name" value="Rrp45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="32"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="12">
        <location>
            <begin position="191"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF87868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="293" mass="32565" checksum="204600A8D3AD357F" modified="2012-06-13" version="1">MPREAEPSLSEKTFLAQALNEGLRLDGRKFDEFRPLEITFGDEYGVAEVKYGKTRVLAKVSAEVTVPYTDRPFDGVFTITSELSPMVAPSYEVNRPSLEEVLLSRLLEKTIRRSGALDTESLCLIAGKKCWSIRVDLHVLAHDGNLTDAACVAVIAALRHFRKPDSSIEGETLTIYTPAEREPVPLSWLHSPFCVTYSFYGEDGSQVLVDTNWLEEKMRVSHCTYSLNKHGEISQISKLGGKALDAPLFIQCAQGALNRSKDLSNIVDNKLAEDAKRRDKGGLMAELTAENDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RNP1</accession>
    <name>I1RNP1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG05625.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T18359</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324187.1">
        <property type="nucleotide sequence ID" value="XM_011325885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RNP1"/>
    <dbReference type="STRING" id="229533.I1RNP1"/>
    <dbReference type="EnsemblFungi" id="CEF87896">
        <property type="protein sequence ID" value="CEF87896"/>
        <property type="gene ID" value="FGRRES_05625"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05625"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18359"/>
    <dbReference type="eggNOG" id="KOG0075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_10_3_1"/>
    <dbReference type="InParanoid" id="I1RNP1"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001015">
        <property type="entry name" value="ADP-ribosylation factor-like protein 8B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF7">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF87896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="184" mass="20917" checksum="1E6260E4EDE49044" modified="2012-06-13" version="1">MAGIFQRVYNWLMRMFWAMEMEVTMVGLQNAGKTSLLRVLAGGEFTLDSIPTVGFNMKKVQRGHVTLKCWDIGGQPRFRTMWERYCRGVSAIVFIVDIADTPLIPQAKEELHDLMSRKSLEGIPLLILGNKSDLPDKLSVDELIDELDLKNIRGREVCCYGISAKEETNLDAVVEFLMKYATRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RNW4</accession>
    <accession>A0A098E0T6</accession>
    <name>I1RNW4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG05706.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T18559</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324282.1">
        <property type="nucleotide sequence ID" value="XM_011325980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RNW4"/>
    <dbReference type="STRING" id="229533.I1RNW4"/>
    <dbReference type="EnsemblFungi" id="CEF87710">
        <property type="protein sequence ID" value="CEF87710"/>
        <property type="gene ID" value="FGRRES_05706"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05706"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18559"/>
    <dbReference type="eggNOG" id="ENOG502S4UR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_11_1_1"/>
    <dbReference type="InParanoid" id="I1RNW4"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="6"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF87710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="407" mass="44553" checksum="777A08C4602C4D95" modified="2012-06-13" version="1">MSRTIEQSIQAAIDSGKINGAVICATNSRGDFSYNTALGQRTLLSGEKHPQKLDDILCFASASKLPTSIAALQCVEEGLLTLKEDLSTVAPELAEKKVLTGWSENDEPLLDDAAQKITLEMLLTHSAGTTYDFLNPSIGKWSAKYKPKDEGKKNVEDTFIYPLCHQPGAGWMYGSSLDWAGRIVERLTGDTLEKRFHERILKPLGCSNDFQFHPVTREDLRERYVDLNPDDPQGLGLAVMGQGASINIRSSGCFGGHGLAMSATDYIKILQSLLSNDGKLLKPETVDDMFQNHLNPESAAGHQAMLATPMGPFFRVGIDENTKLGHGLGGALTLEDIDGWYGAHTMSWGGGLTLLWFIDRKNDICAVGAICAALPLDDEITKTATDLKDVIRKDIYRKYAGWKESNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1RPE3</accession>
    <name>I1RPE3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG05910.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T19059</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324519.1">
        <property type="nucleotide sequence ID" value="XM_011326217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RPE3"/>
    <dbReference type="STRING" id="229533.I1RPE3"/>
    <dbReference type="EnsemblFungi" id="CEF88142">
        <property type="protein sequence ID" value="CEF88142"/>
        <property type="gene ID" value="FGRRES_05910"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05910"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19059"/>
    <dbReference type="eggNOG" id="ENOG502ST13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112120_0_0_1"/>
    <dbReference type="InParanoid" id="I1RPE3"/>
    <dbReference type="OrthoDB" id="25408at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTF2" evidence="1">
        <location>
            <begin position="16"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF88142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="169" mass="19065" checksum="A2FBC1133BD6C952" modified="2012-06-13" version="1">MPLPNTTNEVQASSDAAEIFTTHYYQAVNRHQDLLPFYVNSSSRYPVSADISINGAVIPTPADYSKLLEVQGKDVHYDVESLDAHVLNPSFTMGAPENIYDNAKREKNGEKMSVLVTVMGRVQYGKGREAPQKMFNETFVLVPNWEAMTKLPPRGIRKWLIMSQNFRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I1RPG2</accession>
    <accession>A0A098E1G7</accession>
    <name>I1RPG2_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG05931.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T19105</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324541.1">
        <property type="nucleotide sequence ID" value="XM_011326239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RPG2"/>
    <dbReference type="STRING" id="229533.I1RPG2"/>
    <dbReference type="EnsemblFungi" id="CEF87447">
        <property type="protein sequence ID" value="CEF87447"/>
        <property type="gene ID" value="FGRRES_05931"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05931"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19105"/>
    <dbReference type="eggNOG" id="KOG2307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056777_0_0_1"/>
    <dbReference type="InParanoid" id="I1RPG2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="46"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF87447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="289" mass="31627" checksum="05B20C4A68190F47" modified="2012-06-13" version="1">MAAAPDSLASSMAGLGVSKQFTLSSSDSSSSVGDDAPLPFPEALPRADFLAEDFQPAAYLSALPHRHQTLEDLRSDLRDRSAAISSELLELVNSNYTAFLSLGSELRGGDDKVENAKVSLLGFRRAVEEVKTKVTERREETNTLNGELRGVRSAIEKGRKMIELSERLASLEERLSLDSLPADEDWDEDSEDEGEDDNYGSSTAKLLTSAQECSRITKLLESMDPDTPYVIKMEERLTRCRNTLLLDLGNALKEAKKAGVKGQDRVLKCLAIYRVLDAQSEAVKALRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RPG3</accession>
    <name>I1RPG3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG05932.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T19103</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324542.1">
        <property type="nucleotide sequence ID" value="XM_011326240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RPG3"/>
    <dbReference type="FunCoup" id="I1RPG3">
        <property type="interactions" value="258"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF86784">
        <property type="protein sequence ID" value="CEF86784"/>
        <property type="gene ID" value="FGRRES_05932"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05932"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19103"/>
    <dbReference type="eggNOG" id="KOG1569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_1_0_1"/>
    <dbReference type="InParanoid" id="I1RPG3"/>
    <dbReference type="OrthoDB" id="1747252at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF86784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="301" mass="33034" checksum="4990C3C7C5CE731C" modified="2012-06-13" version="1">MAPIDRCLASMARLSLLQTSRPAIPSIPKFLAPAAAQQVRQASVVRIRKTAKKKKPLPKDFKRHNLNKREFPQYSLCEAMRILRAVEVGEPPASIKYELHINLKTARNGPVIKNSVRLPHPVQSDWQIAVVCPEGSEIARDATAAGAVAVGQETLFEAIRQEKINFDRLICHEASEAALNKAGLGKILGPKGLMPSKRMRTIVPDVVKSMRDSAGAADYRERQGVIRLAIGQLGYSPDQLKNNIKVLLAKIKAECTEISEEVHKEVHEVILSTTHGPGISLNGNLKDAEEKITPEALSSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>I1RPM6</accession>
    <name>I1RPM6_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">FG06001.1</name>
        <name evidence="14" type="ORF">FGRAMPH1_01T19265</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the 4HPPD family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324620.1">
        <property type="nucleotide sequence ID" value="XM_011326318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RPM6"/>
    <dbReference type="SMR" id="I1RPM6"/>
    <dbReference type="STRING" id="229533.I1RPM6"/>
    <dbReference type="EnsemblFungi" id="CEF88760">
        <property type="protein sequence ID" value="CEF88760"/>
        <property type="gene ID" value="FGRRES_06001"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06001"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19265"/>
    <dbReference type="eggNOG" id="KOG0638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034004_3_1_1"/>
    <dbReference type="InParanoid" id="I1RPM6"/>
    <dbReference type="OrthoDB" id="414569at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000001">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000020">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF1">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="VOC" evidence="13">
        <location>
            <begin position="43"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="13">
        <location>
            <begin position="221"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CEF88760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="424" mass="47812" checksum="45B635E368A529BE" modified="2012-06-13" version="1">MSPSAITNSPPQQAVQPTTVPIASSLDKVDNTFAVQPPPNFTGYDHITWWVGNAKQAASYYTNLFGFKPIAYKGLETGSRYFASYVIENNGVRFVFTSPLRSEAHFPDDEPISKSDRKLLKEMYAHLERHGDAVKDVAFEVENVEGVYHKAVQEGAVAVQDPKVSKDKEHGGVSTAVICTYGDTTHTLISRQNYTGPFLPGYRAWKKHSATVTLPEVPLVRIDHCVGNQSWNEMDSACAFYEQCLSFHRFWSVDDSQICTEFSALSSVVMASPNNVVKMPINEPAMGKKKSQIEEYVIFNSGPGVQHIALLTHDIIASVTALRARGVDFIDVPSTYYTNMRHRLKTERRNWELKEEFETLERLNILIDYDEGGYLLQLFTKPLMDRPTVFIEIIQREEFDGFGAGNFKSLFEAIEREQAERGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>I1RPN6</accession>
    <accession>A0A098E4Y6</accession>
    <name>I1RPN6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG06012.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T19287</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324631.1">
        <property type="nucleotide sequence ID" value="XM_011326329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RPN6"/>
    <dbReference type="FunCoup" id="I1RPN6">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RPN6"/>
    <dbReference type="EnsemblFungi" id="CEF88797">
        <property type="protein sequence ID" value="CEF88797"/>
        <property type="gene ID" value="FGRRES_06012"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06012"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19287"/>
    <dbReference type="eggNOG" id="KOG0064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007587_5_0_1"/>
    <dbReference type="InParanoid" id="I1RPN6"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000636">
        <property type="entry name" value="ATP-binding cassette sub-family D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF69">
        <property type="entry name" value="PEROXISOMAL LONG-CHAIN FATTY ACID IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="463"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF88797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="709" mass="80321" checksum="4BFF1761B0799FDC" modified="2012-06-13" version="1">MGSQSKLALPGDRTLKGIISQLTGLYVSNRTRISRAVWITLFAALVNRIRLAISEQKAASVREAAQRAARRGTTSSGSEETPRKKVELNREFFRSLLKLLKIVVPGWRSKESRLLMSHSFFLVLRTLISVRVAEMDGAIVKALVKGNGKEFLKRIVWWMLIAVPATFTNSMLSYHQAELSLKYRSRLTQHIHDKYLSNLTFYGISALDDRIKNPDQLIAVDVSKFSNSLAELYSNLAKPLLDMTIYTWSLSKSVGGEGVVFMSLLVQLSANVMRALTPPFGKYVADEARLEGEFRFQHSRLIDYSEEIALYGGHNAEKDTLDKGYFTLIKHVNYILRRRFYHGFMEDFVIKYFWGALGLMLCSVPVFIKMPGHIAMNMGDRTEAFVTNRRMLLSASDAFGRIMFSYREVMELAGYTSRVATLLDVMTDVQAGHFEKKLVSSSGIEGNEAVLKGRGTVHESNDITFIDVPIISPNGDVLIKALSFTLKHGDHLLVVGPNGCGKSSLFRILGGLWPVYGGTVYKPPFHAIFYIPQRPYLSRGSLRQQIIYPDSLRQMRARGITDADLVEYLKILGLEHLPGLYDEGWDAEAEWRDVLSGGLQQRIAMARLFYHRPKYAILDECTSSVTLEIEKAMYDTAKSLGVTLMTVSHRRSLWKYHSHILQFDGQGNYVFTKLDADRRLKLEDEKEDLEVRLRQVPELERRIAELTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQ21</accession>
    <name>I1RQ21_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG06154.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T19623</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324787.1">
        <property type="nucleotide sequence ID" value="XM_011326485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQ21"/>
    <dbReference type="FunCoup" id="I1RQ21">
        <property type="interactions" value="1525"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RQ21"/>
    <dbReference type="EnsemblFungi" id="CEF87737">
        <property type="protein sequence ID" value="CEF87737"/>
        <property type="gene ID" value="FGRRES_06154"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06154"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19623"/>
    <dbReference type="eggNOG" id="KOG0102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_1"/>
    <dbReference type="InParanoid" id="I1RQ21"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
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        <property type="term" value="F:unfolded protein binding"/>
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    <dbReference type="CDD" id="cd11734">
        <property type="entry name" value="ASKHA_NBD_HSP70_Ssc1_3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Molecular chaperone DnaK"/>
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        <property type="entry name" value="Molecular chaperone DnaK"/>
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        <property type="entry name" value="Actin, Chain A, domain 4"/>
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        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
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        <property type="entry name" value="ATPase_NBD"/>
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        <property type="entry name" value="Heat_shock_70_CS"/>
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        <property type="entry name" value="HSP70_C_sf"/>
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        <property type="entry name" value="Hsp_70_fam"/>
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        <property type="entry name" value="PRK00290.1"/>
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    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="644"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="575"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CEF87737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="676" mass="73071" checksum="8E499DEA742DF102" modified="2012-06-13" version="1">MLASRLSRALPRASPLAARSAAFTRSPLASRFARYESTESDGKVQGAVIGIDLGTTNSAVAIMEGKVPRIIENAEGARTTPSVVAFAEDGERLVGVAAKRQAVVNPENTLFATKRLIGRKFKDAEVQRDIKEVPYKIVQHTNGDAWVAARGQNYSPSQIGGFVLNKMKETAEAYLSKPIKNAVVTVPAYFNDSQRQSTKDAGQIAGLNVLRVVNEPTAAALAYGLEKEADSIVAVYDLGGGTFDISILEIQNGVFEVKSTNGDTHLGGEDFDIHLVRHLVQDFKKTSGIDLSGDRMAIQRIREAAEKAKIELSSSLSTDINLPFITADSSGPKHINMKLSRAQLEKMVDPLISRTIEPVRKALKDAGLSAKEIQEVILVGGMTRMPKVAESVKGIFGRDPAKSVNPDEAVAIGAAIQGAVLSGEVKDLLLLDVTPLSLGIETLGGVFTRLINRNTTIPTKKSQVFSTAADFQTAVEIKVYQGERELVKDNKMLGNFQLVGIPPAHRGVPQVEVTFDIDADSIVHVHAKDKSTNKDQSITIASGSGLSESEIEQMVEDSEKYAEADKERKGAIEAANRADSVLNDTERALNEYADKLDKTEADSIKEKLTTLREFVAKNLSGEGTATAAEIKEKTDELQVASLNLFDKMHKARNDNSGEQSSSEQSQEGEKKDETKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQ44</accession>
    <name>I1RQ44_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG06180.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T19689</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324818.1">
        <property type="nucleotide sequence ID" value="XM_011326516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQ44"/>
    <dbReference type="STRING" id="229533.I1RQ44"/>
    <dbReference type="EnsemblFungi" id="CEF88301">
        <property type="protein sequence ID" value="CEF88301"/>
        <property type="gene ID" value="FGRRES_06180"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06180"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19689"/>
    <dbReference type="eggNOG" id="ENOG502SJ1Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013199_0_0_1"/>
    <dbReference type="InParanoid" id="I1RQ44"/>
    <dbReference type="OrthoDB" id="5333304at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF88301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="834" mass="93059" checksum="223E52126D902B99" modified="2012-06-13" version="1">MAQEVTARGTLISKNELSGLADNQRYQIEQYEKIVRLRDAILSGQHPTIKPSNLNASTKSSSARPIDISSSHGASNNQSDKRQQVGVSASASSSSAKNTKPYGTGSTKIDPIFLEKSDDLVKAELRLQRQKLERVLKDEVEQKKATTKSAVQGEPVVEFDLSQVLSEALTRVQSTTVPDTTVSAAADATNPDNASDSFDDNTFYSSQHNTPSSVLTSRVRNESEEAQVPASEPRPPMNYHSNAILQNRPTDAEQIHPEARNRPQPQPYSNPAAFAGSFGADSTTRPGQVPGLTAYIEDKTGPRQDASAGQSPSNLDIDRHRGNYGSAQQPPREQYIDSRPPSPLRRINARSSHDAHTSPLANARRRPLAPEVTSASSTGTPAQIAALRNEPIAVTSPESSPQGGPASEKEKRKTKKKKRKADRQAPEAEPTPYIKPEPRSPSPLNAPSYIRPNKRQRYTQQQPDEPGYEEIRYEPHPAQYLPEFPHIRQERDDRMPISYERVGFPSQRAASTAVPGGTVYRREYADDRYVQGGSYAVEQSPLVPAHHQRQSVGGTAGPQVHPHDTYQQRPSWPYSGGHEASPSTLRGDGDVFMTPHRPPPTRIIVDAFGREYIEPPRPTIIRQSAAPHARSGEPEVIYERAAPRRPQGAETYDEGGAVYRRRSPSYMPRRVVTQPEYIPQDYRDQRPHEQPSRPLGHPGDFVEVMAPPERRRLENGTMEYITRPPSVRPAEPVRYEVARDYGRLQSVRPEVPVRQYAPSVHPENRREAAQPYGREYGALPVEQGVVRQEYSTRPVERYYNQQMRGGEEIAFIEQPRGATQEIVYADDARREVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQB0</accession>
    <name>I1RQB0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG06251.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T19867</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324899.1">
        <property type="nucleotide sequence ID" value="XM_011326597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQB0"/>
    <dbReference type="EnsemblFungi" id="CEF88045">
        <property type="protein sequence ID" value="CEF88045"/>
        <property type="gene ID" value="FGRRES_06251"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06251"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19867"/>
    <dbReference type="eggNOG" id="ENOG502QU1R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087046_0_0_1"/>
    <dbReference type="InParanoid" id="I1RQB0"/>
    <dbReference type="OrthoDB" id="3944408at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF88045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="246" mass="27290" checksum="6E1BE661DF096E90" modified="2012-06-13" version="1">MTPNSENGMARFLMAILNQKNLKDIDWNAVASDPVLLQPITNGHAARMRYTRFRDTVRGHQPQKRARAEDKSRVAKSKKTQKPKNQSLAKPNSAESIASYAQAHQSPLIKQEKNQGYLAQFSPASTLSPYPTDRRDDFDHRFLTPCSDDMQGLAINPASLEDLRISNGFGPSMDSAPDFMAQPLHDPIVVGQSPFHTFDPPYDLTSFKPTISGDPHGSPDVVDFNGTSSLADCSPGWMDHFNDQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RR17</accession>
    <accession>A0A098DR18</accession>
    <name>I1RR17_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG06521.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T22493</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326131.1">
        <property type="nucleotide sequence ID" value="XM_011327829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RR17"/>
    <dbReference type="EnsemblFungi" id="CEF84291">
        <property type="protein sequence ID" value="CEF84291"/>
        <property type="gene ID" value="FGRRES_06521"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06521"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22493"/>
    <dbReference type="eggNOG" id="ENOG502S4CM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058475_0_1_1"/>
    <dbReference type="InParanoid" id="I1RR17"/>
    <dbReference type="OrthoDB" id="408973at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025870">
        <property type="entry name" value="Glyoxalase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40265">
        <property type="entry name" value="BLL2707 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40265:SF1">
        <property type="entry name" value="GLYOXALASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13468">
        <property type="entry name" value="Glyoxalase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF84291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="276" mass="30031" checksum="B3833411297D2253" modified="2012-06-13" version="1">MSLPILDHFAILVSYRTLQTVTDTLKDSLLVIDGGAHADGLTVNKLIHLADGTYLEFIAFVEGVDPEKRRAHRWGNLEEGKIADWAHTLNSEADYAALQKRVADAGNGVTYGDLTSLQRHRPDGVLMKCLVSVALDPEGGRIFPGTIPFWCVDETERHLRSPFKTDGGDGLHEYTKHPSHAQGVSKVTVLLPEKDIATYKPVYDAIHNQKAAEGKEHSWPYDLPAGPNAGSNKVVLSTLEGGNGKAEIKLALLGTKDSPRSIELLPGLTVDFEHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I1RRE6</accession>
    <name>I1RRE6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG06665.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T22865</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326294.1">
        <property type="nucleotide sequence ID" value="XM_011327992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RRE6"/>
    <dbReference type="EnsemblFungi" id="CEF84604">
        <property type="protein sequence ID" value="CEF84604"/>
        <property type="gene ID" value="FGRRES_06665"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06665"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22865"/>
    <dbReference type="HOGENOM" id="CLU_1635550_0_0_1"/>
    <dbReference type="InParanoid" id="I1RRE6"/>
    <dbReference type="OrthoDB" id="10316846at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF84604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="162" mass="17830" checksum="D59942866F8EA6B5" modified="2012-06-13" version="1">MVDQFYAGAQCENIAIFRHSLTEEAVMFYQIEKQLLGYLIDINGKSSRLSDRKCLLGCCILDSKLFGHMSFKVDEIKPMDNPPGPEVSEDCENKDQDILNPTSAKQKACTIGHSHVLTAPLHLVFGGLVSPASTKRLDNQRGRGEVGLDDGPLSLALVWVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>I1RRS3</accession>
    <name>I1RRS3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG06810.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T23239</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326463.1">
        <property type="nucleotide sequence ID" value="XM_011328161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RRS3"/>
    <dbReference type="STRING" id="229533.I1RRS3"/>
    <dbReference type="EnsemblFungi" id="CEF84091">
        <property type="protein sequence ID" value="CEF84091"/>
        <property type="gene ID" value="FGRRES_06810"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06810"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23239"/>
    <dbReference type="eggNOG" id="ENOG502QZJZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011099_0_0_1"/>
    <dbReference type="InParanoid" id="I1RRS3"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="PHI-base" id="PHI:12191"/>
    <dbReference type="PHI-base" id="PHI:1816"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="146"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="736"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="771"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF84091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="893" mass="98974" checksum="B1C248118175E0CF" modified="2012-06-13" version="1">MDHMAFQVPGMAPPIMNHPPPQVFGSYDGIPQLHPEIAAQMFNDSAMMLEDANDPKRRRIARACDMCRKKKIKCDGKMPSCTHCINYKTECVFTQVEKKRAPPKGAKYIEGLENRLNRMEHLLRLSGLLDEDDDDLGALEKRLMERQHKSRQASMAVGSGPNSPTHSTSAPSAIDASAMTPQSSLTSPNPIVKEDKRKSATPAPSTAPSTAPAPNANGEEVKTEEPEEVEALSEMMCSLVTNNYGETRYIGSSSGFSIFSPKGVSWVNSKTGDDSFQRTISDISVDDHKWTNWKPEVFSDLFQRPVFRPLPPKTEALSLLQDYFDNFNCIFPLFHQPTFMHLVQMQYSSEPYQGSGWWASLNCALAIAHRLRVMSNLVPQDEDEKAWGYLKNAIGVFPELTMRNTDLLSVQALLGMALFLQGTPNPQPTFLLVSAAMRLAQSIGLHKRGTGFNLNPIEIEQRKRVFWIAYMLDKDLCLRAGRPPAQDDDDMNVELPDADPADNIGNIPLADGKGKMNLFRVMCEFATIESEVYKRLYSVQATKQSDGELLNTIGELDQKLEEWKDSIPIDYRPEHDINASHTPLILHVVMLHLTYYNCLTTIHRMSVHHGYWTSRLANYAIQGLNARPLNPRVFSSAALCTAAARASVSLLKYVPQGDFACVWMILYFPVSALVTLFGNILQNPLDPRAKSDTRLMNIVVTFLSMLGQEAEQGGVHRMLGICAEFERIAKAVIDKAEKEQSSRRKRKNQDSANKSSANVPAARNAAKESVRSASVSSTAHRRSSQAQLSPPSNGDSMGAFSVGTPMNDLSPSAMSAGWPQEFPVPQPHQNGDYDSAMSYGEGSMHSPGMPVSAFQQPLLPQDLFSLPMTLDWSWAEMTTGAYPTVENGNFGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RRT1</accession>
    <name>I1RRT1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG06820.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T23263</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326474.1">
        <property type="nucleotide sequence ID" value="XM_011328172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RRT1"/>
    <dbReference type="STRING" id="229533.I1RRT1"/>
    <dbReference type="EnsemblFungi" id="CEF83065">
        <property type="protein sequence ID" value="CEF83065"/>
        <property type="gene ID" value="FGRRES_06820"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06820"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23263"/>
    <dbReference type="eggNOG" id="KOG4373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016103_0_0_1"/>
    <dbReference type="InParanoid" id="I1RRT1"/>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="4">
        <location>
            <begin position="165"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF83065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="547" mass="62620" checksum="77A9984B588800D1" modified="2012-06-13" version="1">MSPTIKNRLWNPAFGIRFSPEADHQPPYPFLDINRFVHTPASSSEVVRNEEVEINEFSEDEEFERDAAEWFDQQDRLEFPMVESISEGTQVATDTDGNLVDASKQDVITTETITVAPPLTSLDYALDVDQWEAARKCKQGSQESFWSYRMYRRIQEDGEEQRVKVHYCTSKQTMESVCRRYFADEKVIGFDLEWLIRHRNTDPRVNVSLIQIASPSRVALFHVALYPKDDFVAPTFKKIMEDESVTKVGVCIKGDCTRLKNNLGIESRGVLELSHLFKLVKYSKSGELKRINKIMVNLAAQTQEVLGLPLFKGNDVRSSNWMLPLSEQQISYSASDAYVGLQLYHVLEQERLKLQPTPPRPEFVEKGLPIKFLAADDVDESDDTSESGDSEVISDVEAELEELEVELAQTPTKSTKRKTTKATKATPEETKEVHTRDHRVIVAEDHAIQYRNQEHVVRVTMSSLRAYFLWHDNEGLTPESIAVLLRTPPLKTNTVVTYILDVITSEKLPYEKTRLREEVLVHLSPQTQYSNKFRALVEAAQESEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1RS71</accession>
    <name>I1RS71_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG06984.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T23671</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326663.1">
        <property type="nucleotide sequence ID" value="XM_011328361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RS71"/>
    <dbReference type="STRING" id="229533.I1RS71"/>
    <dbReference type="EnsemblFungi" id="CEF83410">
        <property type="protein sequence ID" value="CEF83410"/>
        <property type="gene ID" value="FGRRES_06984"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06984"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23671"/>
    <dbReference type="eggNOG" id="ENOG502SE0J">
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    <dbReference type="HOGENOM" id="CLU_051207_0_0_1"/>
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    <dbReference type="OrthoDB" id="5385189at2759"/>
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        <property type="component" value="Chromosome 4"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="16"/>
            <end position="39"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF83410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="332" mass="38478" checksum="F056517417F4FE79" modified="2012-06-13" version="1">MGWADSLLKFARDERVVLLTLGLATFGVVSTVFTALTIIRDDNEIPPLQPKTQYITQDTEDSLQLETLEKLLDHPNYSIREVAVKILCDRAVNDPETTHSLLFGITRPDYDERMRCLRAMALLTGQTIGLDGLSKLNNPKAYSALVRSLELSLDDVERPSLTDSHWDEYYLRDMAERFCLMFILELVNKYGASMLIKARFVEKWLAKQDWGATPEERRRSFKDYMALKVNRIVEIVDRIKETRRGLRALEKAGLLDKENSRRRIRELPDLIMEIEEEAGNMPLVEQQPTRTREHSAEEQRLRRQHREAMVLNDGTRPLAREDIIEREHTSPA</sequence>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_011327136.1">
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        <property type="gene ID" value="FGRRES_07373"/>
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    <dbReference type="eggNOG" id="ENOG502QUEX">
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    <dbReference type="HOGENOM" id="CLU_011125_1_0_1"/>
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        <property type="entry name" value="LCCL"/>
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        <property type="entry name" value="LCCL_sf"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="3">
        <location>
            <begin position="234"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF84229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="671" mass="74754" checksum="ABE7CE0CFB689F84" modified="2012-06-13" version="1">MVSHEEEESQPLMAGPDPIDVSVVPVSGSNSNSDNEHDRSNANHPDAPLESNSRLEVDDSDPPTPRFIQDESSWKRWKWVPYPVRRSVNWVAKWSHGPTNPQPYRIKPFFPTIQEYPLFLLERFIPRRKHRLWLVFFYLSIWIVTFALVKRRDSVASEIEGWGMPQTIGCGVSYWGRGNTCGLDGTDCRPFNGSGFPFRCRANCESYHVLNPRAVGNQEVIYAPMVVGGPGTNGSDEPVYRGDSFVCAAAIHAGVISNENGGCGVVELIGRDQEYTASKHHGISSVGFDSYFPLSFRFAPDVTCSSSDSRWELLAVSTVFTGVLSLFTNSPALFFFSVFTGIFWTVGMALDPPPHVSVAALFSNLIGKFLPAMFCAWVMYDKMGVRRTLHGLTAQIEKTILWLGGCWVGGMENYTLSFIPIQRLNKHDLDQQPGARGALAVIIILLAAIITSQVWFFRQEGRLIKYLKLYALLVGAILISLTIPGLSLRIHHYIIALLLLSGTSMQTRPALLYQGILVGLFISGIARWGFDPVLQTSAALQGDAQKGSRLPTIPTPVINLGVGTDAVSNITFNWNEPPAQLYDGISILVNDVERFRTYFGDIDAKRDFVWTRNSSLNLPEYFRFAYMDGSDSGDYTKAGIWTPDGEWTKMKPGPSRVKARSLDKDDLVQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1RTY9</accession>
    <accession>A0A098DQT2</accession>
    <name>I1RTY9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG07659.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T25319</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327450.1">
        <property type="nucleotide sequence ID" value="XM_011329148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RTY9"/>
    <dbReference type="STRING" id="229533.I1RTY9"/>
    <dbReference type="EnsemblFungi" id="CEF83714">
        <property type="protein sequence ID" value="CEF83714"/>
        <property type="gene ID" value="FGRRES_07659"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07659"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25319"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_11_1"/>
    <dbReference type="InParanoid" id="I1RTY9"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05941">
        <property type="entry name" value="MCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF28">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="480"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF83714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="585" mass="63555" checksum="C4086A99728A5266" modified="2012-06-13" version="1">MPFLSSPDSATTLQRSSFLEAIQKHEPASLAVLENDSGATFSYGTLLKSIAHAKDQLLSKTGRTDVSGERIAFMVESGYEYVVTLLAILASNAIALPLAPAFPAPELRYILENSQALVLISSSKYASKAEEVISQDLASPPLFYQLDGTGHATAEEKEIELGELSNSQQGGMMLFTSGTTARPKGVVLTQANLTAQASSLLEAWRYSPSDRLLHVLPLHHIHGTVNALLTPLLAGSSVEFMFPFVVDKVWKRLTAPFQTAAGEKAQVPISFFTAVPTIWARMLKSYDSLSPEMQKAGKEAISPRNLRLNFSGSAALPKPIRDGWIQLSEGNILLERYGMTEVGMALSCGLADVDRVDGSVGWPLPSVEARLMETDDETGVQTVVQPGDEIDSATGKERIGEIQLRGPTIFTGYWRNPEATAKEFTEDGWFKTGDIAIRRSVPGSGKGESGSWAQGPAYFIQGRRSADIIKTGGEKVSALEVEREILSLDQIDECAVVGLPSESWGQKVAAVVVLSQKGDEKMTLPQLRAALKPRITAYKIPQDLEIVETLPRNAMGKINKKELINSVFGPVEKIRRRSIDLGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1RUB5</accession>
    <name>I1RUB5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG07802.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T25701</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327622.1">
        <property type="nucleotide sequence ID" value="XM_011329320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RUB5"/>
    <dbReference type="SMR" id="I1RUB5"/>
    <dbReference type="FunCoup" id="I1RUB5">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RUB5"/>
    <dbReference type="EnsemblFungi" id="CEF84171">
        <property type="protein sequence ID" value="CEF84171"/>
        <property type="gene ID" value="FGRRES_07802"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07802"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25701"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="InParanoid" id="I1RUB5"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000484">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="39"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF84171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="561" mass="59892" checksum="08C1A06860D29E1A" modified="2012-06-13" version="1">MAAMDSSSPVPENPTPGQPPSPLPPGAASSKKGARFWLIFVAIALTTFLAALDTSIISTALPTIAADLGSDSLYVWIIDSYLLASTATIPIFAQAANIYGRRSLTLIAVCIFTLGSGLCGGAHNTAMMVGGRAVQGIGGGGVLTMSEIVVCDMVSIRERGMYAGIIGGVWAIAAVVAPVMGGAFAQNISWRWIFYINLPIAGVALVALGLFLKLTRPPSGTFKEQMARIDWGGSVLLIGSVTSIVLALSWGGSEHAWSDWETVVPLVIGLVALLAFFAYQGVPWLKEPTMPLRLFSNRTSSTLLAISFIHSLLLYWICYFLPVYFQAVKEASPTRSAVMLFPIACTSAPGGVAAGITITKTGKYRIWHFAGFVLMSIACGLFTLLDENSSTGRWVGFQILFGFGTGVVFTSTLPPILASLPDSDVATATGAWTFIRNFGSIWGVAIPAAVFNNHVNHAASDISDQGVRSLLVNGGAYEHATQYFLKTLESSPQLKDEVVQVYLNGLKVVWQVSIAFCLLGFLLCFFVRSLTLRDELNTEFGLQEEKGSGQIKSSEEGVVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I1RW35</accession>
    <name>I1RW35_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG08489.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T10089</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
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    <proteinExistence type="inferred from homology"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="RuleBase" id="RU000488"/>
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    </evidence>
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            <dbReference type="EMBL" id="CEF76847.1"/>
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    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF76847"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="305" mass="33491" checksum="93BA5060EB51EE25" modified="2012-06-13" version="1">MSADQPLPFIYQFAAGAIAGVSEILVMYPLDVVKTRVQLQTGSGATAEYNGMLDCFRKIIKQEGFSRLYRGISAPILMEAPKRATKFAANDEWGKVYRKMFGMDKMNQPLSVLTGATAGATESFVVVPFELVKIRLQDKASAGKYNGMVDCVVKTVKNEGPLTLYQGLESTLWRHILWNAGYFGCIFQVRQMLPKAENKKAQITNDLISGAIGGTFGTVLNTPLDVVKSRIQNTPKVAGQVPKYNWAFPAVGTVLKEEGFSALYKGFLPKVLRLGPGGGILLVVFTTVMDTFRSWHYPVTSALKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>I1RWM0</accession>
    <name>I1RWM0_GIBZE</name>
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        <submittedName>
            <fullName evidence="8">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG08696.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T10593</name>
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    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_011321738.1"/>
    </dbReference>
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    <dbReference type="STRING" id="229533.I1RWM0"/>
    <dbReference type="EnsemblFungi" id="CEF77099">
        <property type="protein sequence ID" value="CEF77099"/>
        <property type="gene ID" value="FGRRES_08696"/>
    </dbReference>
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    <dbReference type="PHI-base" id="PHI:1534"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="MADS_BOX_2"/>
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    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
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            <end position="222"/>
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        <location>
            <begin position="10"/>
            <end position="28"/>
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            <end position="204"/>
        </location>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF77099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="222" mass="24463" checksum="BB1543FA6C8FCC3D" modified="2012-06-13" version="1">MADITDQHDQTSPTELDEQNVGNGNATESRGIKRQRPSAGDDDDDDDEKGSRERRKIEIKFISDKSRRHITFSKRKAGIMKKAYELSVLTGTQVLLLVVSETGLVYTFTTPKLQPLVTKSEGKNLIQACLNAPEPTPGNENGVDGGDQVESPEEPPNQHLPPQGNRPGMPQNPHMPPNNYMPNMPMDPQQALAYQSYVQRNQAYGSGIPPQPGMPANSHHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>I1RYQ7</accession>
    <name>I1RYQ7_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="17">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">FG09515.1</name>
        <name evidence="22" type="ORF">FGRAMPH1_01T26901</name>
    </gene>
    <organism evidence="22 24">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="23">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="24">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="23">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="22 24" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="22">PH-1</strain>
        </source>
    </reference>
    <reference evidence="23" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="16">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="17"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328203.1">
        <property type="nucleotide sequence ID" value="XM_011329901.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I1RYQ7">
        <property type="interactions" value="456"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RYQ7"/>
    <dbReference type="EnsemblFungi" id="CEF85578">
        <property type="protein sequence ID" value="CEF85578"/>
        <property type="gene ID" value="FGRRES_09515"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09515"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26901"/>
    <dbReference type="eggNOG" id="KOG0204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_9_3_1"/>
    <dbReference type="InParanoid" id="I1RYQ7"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="533"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1128"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1162"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="254"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="19">
        <location>
            <begin position="357"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="20">
        <location>
            <begin position="1007"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1253"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1258"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1269"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1290"/>
            <end position="1303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CEF85578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1340" mass="145914" checksum="BADFBE51D7F0EE33" modified="2012-06-13" version="1">MADHDDNPLMRRRAPTITIDTTAVNPNTSTDPPQESHPSHLQDDAVSPTSTADPAATAGMSQRPSRPEVNTSLSFENRDSRPTSPHNVSSPVLSRSGDKGVEFLSVPINHRSRQNSVDSDDMSRSVSSQGDTTVVASNSTQHETLKGSEYDHNKIINDETALKPDTGTEQDFEVENNPFAFAPGQLNKMFNPKSLSAFYKLGGIDGIEKGLRSDRKAGLSIEEKSLGGQVSFEDATSKKQTPHNDVSNTQPGDSFADRLRIYKDNRLPEKKGKSLLQLMWITYNDKVLILLSIAAVVSLAVGLYQTFGGEHKDGEPKVEWVEGVAIIVAIAIVVIVGSLNDYQKERQFTKLNKKKQDRLVKVIRSGKTIELSVFDILAGDVVHLEPGDLVPVDGILIEGFNVKCDESQATGESDIIRKQAAEVVYNAIENRDNLKKMDPFIQSGARIMEGVGTYMATSVGVYSSYGKTLMSLNEDPEMTPLQAKLNVIATYIAKLGSAAGLLLFIVLFIKFLVGLPKMGPGVSPAQKGQQFLNIFIVVVTIIVVAVPEGLPLAVTLALAFATTRMLRDANLVRHLKACEVMGNASTICSDKTGTLTQNKMQVVSGTIGTSLRFGGSQRGDDSNASTPVDTSGDISIGEFAKMLSKPVKDILLKSIALNSTAFEGEVDGEKTFIGSKTETALLILAKSHLGMGPVSEERENAKVLQLIPFDSGRKCMGIICQGPNGSARLYIKGASEIILSKCTQVFRDPANDDSLAPMSDDNTETVKQLIESYARRSLRTIGICYKDFPSWPPKNVSHIDGGKEVVFEDIFMDMAFIGVVGIQDPLREGVPEAVKLCQKAGVTVRMVTGDNKITAEAIAKECGIIQPNSIVMEGPEFRNLSKLQQEEIIPRLHVLARSSPEDKRILVKRLKDKNETVAVTGDGTNDAPALKMADVGFSMGIAGTEVAKEASAIILMDDNFNSIVKALKWGRAVNDAVKRFLQFQLTVNITAVILTFVTAVSNDEESSVLTAVQLLWVNLIMDTLAALALATDPPHDSVLDRKPEPKGSSIISVTMWKMILGQSVYQLVITFLLYYGGKDLVPTKNTPSDDEIKTLVFNTFVWMQIFNQWNNRRLDNKFNIFEGLTKNWFFISISAIMCGGQVLIIFVGGAAFQIAKEKQSGALWAIALVLGFLSIPVGILIRLIPDHFLLVLVPEFLKQRANKVPGLTVSDEEMSMYPEPLADVRDELNFMRRMKGGRLNNLKFAIQHPKEAVEMVRSRSPSRSRSGSVNAPQTPTQENPFEGSPIGTPNSVRTRSTRSRSNSALGAPTVMAGIVAAGVAAGWQPKMRPADDGDNTNAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RYR0</accession>
    <name>I1RYR0_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit DUO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein DUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">FG09518.1</name>
        <name evidence="20" type="ORF">FGRAMPH1_01T26893</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="21">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="22">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="21">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="20 22" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="20">PH-1</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DUO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328200.1">
        <property type="nucleotide sequence ID" value="XM_011329898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RYR0"/>
    <dbReference type="STRING" id="229533.I1RYR0"/>
    <dbReference type="EnsemblFungi" id="CEF83166">
        <property type="protein sequence ID" value="CEF83166"/>
        <property type="gene ID" value="FGRRES_09518"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09518"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26893"/>
    <dbReference type="eggNOG" id="ENOG502SCC0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074400_1_0_1"/>
    <dbReference type="InParanoid" id="I1RYR0"/>
    <dbReference type="OrthoDB" id="5599235at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013960">
        <property type="entry name" value="DASH_Duo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08651">
        <property type="entry name" value="DASH_Duo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="124"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CEF83166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="227" mass="25093" checksum="DB8C6F4D0AF189C9" modified="2012-06-13" version="1">MADDTTEYTESNIWQSPSQEDGPPTSRPRTPKTPKTPKTPTQERPEPLDREAALRKELEGVRNINESLEGVISTLERAGGNMNTVLSTVNNASVLLNTWTRILSQTEHNQRLLLDPGWKGATEDMAEQEAEAIQKQQAAERKAAEEEERREQLRQRREEEEERRRLAASAPARGTRGTRGVRGTTRARGTTRAGSSTASSTSRTSSIPSRGTSNIGRGFGARRARGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZ38</accession>
    <name>I1RZ38_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="16">1.3.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">2-methyl branched chain acyl-CoA dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">2-methylbutyryl-coenzyme A dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="primary">FG09661.1</name>
        <name evidence="31" type="ORF">FGRAMPH1_01T26571</name>
    </gene>
    <organism evidence="31 33">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="32">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="32 33" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="33">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="32">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="31 33" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="31">PH-1</strain>
        </source>
    </reference>
    <reference evidence="32" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="32">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(2R)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156439"/>
            <dbReference type="ChEBI" id="CHEBI:156440"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:65297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57336"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:43781"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62500"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:44181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>valproyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65344"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156457"/>
            <dbReference type="ChEBI" id="CHEBI:156458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:65345"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 27">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid degradation; L-isoleucine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 27">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.5" evidence="16"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328047.1">
        <property type="nucleotide sequence ID" value="XM_011329745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZ38"/>
    <dbReference type="STRING" id="229533.I1RZ38"/>
    <dbReference type="EnsemblFungi" id="CEF85108">
        <property type="protein sequence ID" value="CEF85108"/>
        <property type="gene ID" value="FGRRES_09661"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09661"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26571"/>
    <dbReference type="eggNOG" id="KOG0139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_0_1"/>
    <dbReference type="InParanoid" id="I1RZ38"/>
    <dbReference type="OrthoDB" id="10262177at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003853">
        <property type="term" value="F:short-chain 2-methyl fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046395">
        <property type="term" value="P:carboxylic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01158">
        <property type="entry name" value="SCAD_SBCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
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        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF1">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 27" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 27" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 27" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="30">
        <location>
            <begin position="69"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="29">
        <location>
            <begin position="183"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="28">
        <location>
            <begin position="290"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039036"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00039850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00041537"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048307"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048592"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="CEF85108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="445" mass="48479" checksum="2B0298A0C08F6C1C" modified="2012-06-13" version="1">MSSFTRVVRPALRGGRSLTQRIAPPATTPRSMTRTNLNTARLLSTTQCRRNEHIDISEIPPTPITHLSELETAMVDTVSKFATDVILPRARDMDEAEEMDPAVVEQLFEQGLMGIEIPEEYGGAGMNFTAAIIGIEELARADPSVSVLVDVHNTLCNTAIIKHGSTAIKKKWLPRLATNTVASFCLSEPVSGSDAFAMATRATETADGFKINGSKMWITNSKEADLFIVFANLDPSKGYKGISAFLVEKGMKGFSIAKKEKKLGIRASSTCVINFDDVEIPKENLLGERGQGYKYAISILNEGRIGIAAQMTGLALGAFDNAARYVWNDRKQFGSLVGEFQGMQHQLAQAYTEITAARALVYTAARKKEAGEDFVKDAAMAKLYASQVAGRVSGSAIEWMGGMGFVREGLAEKYFRDSKIGAIYEGTSNIQLNTIAKLLQKEYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZL3</accession>
    <name>I1RZL3_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fimbrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG09862.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T06705</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318764.1">
        <property type="nucleotide sequence ID" value="XM_011320462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZL3"/>
    <dbReference type="SMR" id="I1RZL3"/>
    <dbReference type="FunCoup" id="I1RZL3">
        <property type="interactions" value="617"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RZL3"/>
    <dbReference type="EnsemblFungi" id="CEF75157">
        <property type="protein sequence ID" value="CEF75157"/>
        <property type="gene ID" value="FGRRES_09862"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09862"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06705"/>
    <dbReference type="eggNOG" id="KOG0046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015284_3_0_1"/>
    <dbReference type="InParanoid" id="I1RZL3"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="PHI-base" id="PHI:3996"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099079">
        <property type="term" value="C:actin body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120106">
        <property type="term" value="C:mitotic actomyosin contractile ring, distal actin filament layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044837">
        <property type="term" value="P:actomyosin contractile ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070649">
        <property type="term" value="P:formin-nucleated actin cable assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21294">
        <property type="entry name" value="CH_FIMB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21300">
        <property type="entry name" value="CH_FIMB_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21303">
        <property type="entry name" value="CH_FIMB_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000016">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000027">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="140"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="289"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="414"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="539"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF75157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="649" mass="72252" checksum="394C79F74EFEC0C8" modified="2012-06-13" version="1">MNVLKLQRKFPQFQQNEIFTLSDAFQRLDVDDKGYLDEATAIKATQQSENQPYDVVRQALKEVELDSSRRVELEDYVSLVAKLRDSSPAQKRMSTGPTSSPGGGGGVVAQRTGGHASKGSLSGKIQVQGSNANITHTINEDERTEFTRHINAVLAGDSDIDSRLPFPTDTFEMFDECKDGLVLAKLINDSVPDTIDERVLNIPGRKIKNLNAFHMSENNNIVIESAKGIGCSVVNIGAGDIIEVREHLILGLIWQIIRRGLLGKIDIKLHPELYRLLDEDETLEQFLRLPPEQILLRWFNYHLKAAKWSRTVNNFSSDVKDGENYAVLLAQIGPEYGVTRAPLQKQDLHDRAEAVLQEADKLGCRKFLTPKSLVAGNPKLNLAFVANLFNNHPALDPITEEEKLEVEDFDAEGEREARVFTLWLNSLDVQPAVVSFFDDLRDGSILLQAYEKVIPNSVNPRHVNKRPAHGGEMSRFKAVENTNYAIELGKQNGFSLVGIQGADITDGQRTLTLGLVWQLMRKNITVTLSSLAQKLGKREITDSEMVRWANDMSQKGGRNSAIRSLKDPSIGSGIFLLDVLNGMKSSYVDYDLVTAGQTDEDAYLNAKLSISIARKLGATIWLVPEDICQVRSRLITTFIGSLMATHEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I1S024</accession>
    <name>I1S024_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GCS light chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Gamma-ECS regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Gamma-glutamylcysteine synthetase regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamate--cysteine ligase modifier subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG10036.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T07131</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a catalytic heavy chain and a regulatory light chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318963.1">
        <property type="nucleotide sequence ID" value="XM_011320661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S024"/>
    <dbReference type="STRING" id="229533.I1S024"/>
    <dbReference type="EnsemblFungi" id="CEF75370">
        <property type="protein sequence ID" value="CEF75370"/>
        <property type="gene ID" value="FGRRES_10036"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10036"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07131"/>
    <dbReference type="eggNOG" id="KOG3023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055657_0_0_1"/>
    <dbReference type="InParanoid" id="I1S024"/>
    <dbReference type="OrthoDB" id="5596051at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035226">
        <property type="term" value="F:glutamate-cysteine ligase catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032963">
        <property type="entry name" value="Gclm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295:SF4">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="10">
        <location>
            <begin position="93"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF75370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="312" mass="34462" checksum="D8EE269150647BF8" modified="2012-06-13" version="1">MTRLILSTANVMLAGPSIIRKPGNARSNLELVNSLRDNIAEAQRDYATDTEGTNGFTNDNALNGNHTAVELWTEQQDDALYVPRINWNAAGLREEPSQYEITVKFFVLSGMSDKAREQHVKEALDLVRRELGITTIDLLIVSFPGISFEGSCEWEADKTNAHQGNLEEELATWKVFESLHKQGLVKRLAVAEFGSEKLSAFIKHTTVRPVIDQINLRNCCDVPPPLKKLAEDEGVELHVHNDCTDILPHGTLRELLSHGSKGAGLLADSSNNGSGLTGELVPEWVVRYTAFVQDRGVIENKGYFAGAELVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>I1S1C5</accession>
    <name>I1S1C5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG10525.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T08331</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319519.1">
        <property type="nucleotide sequence ID" value="XM_011321217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S1C5"/>
    <dbReference type="EnsemblFungi" id="CEF75969">
        <property type="protein sequence ID" value="CEF75969"/>
        <property type="gene ID" value="FGRRES_10525"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10525"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08331"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_4_1"/>
    <dbReference type="InParanoid" id="I1S1C5"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="PHI-base" id="PHI:5893"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000014">
        <property type="entry name" value="Proteinase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124647" evidence="8">
        <location>
            <begin position="17"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="10">
        <location>
            <begin position="27"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="142"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF75969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="400" mass="42769" checksum="A57FEA081709834C" modified="2012-06-13" version="1">MLSVKILLALLPSALAQFTIGEVVEDNYIITLKPKVNETEIEQHIEWVDDIHTASLLRRGEDGVDKVWNSTFKGYCGEFDKSTIRRINQSEDVLAVEPVKKVTLATVQRNAEWGLASISHRTTGSTDYLYDASAGNGMYAYLVDTGINYGHRDFQGRASPGYNAYPGVPFVDVNGHGTHCAGTIAGKVYGVAKRANLIAVKVFHSGSSTTAIVLDGYNWAVNNITNTPGRNQQSVISMSLGGGKSDAFNLAVEMAYRQNIHTVVAAGNSNVNANDTSPASAQNATTVGAIDKNNNRASFSNFGPFVDIFAPGVSIKSTWIGSDSATETLSGTSMACPHVAGLSLYLRAKEGLKTVKSVQDRIKQLATKNVIANAGAGSPNLLAYNGGVPTRTTFRKGDWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I1S296</accession>
    <accession>A0A098E1V6</accession>
    <name>I1S296_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG10882.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T20705</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325504.1">
        <property type="nucleotide sequence ID" value="XM_011327202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S296"/>
    <dbReference type="STRING" id="229533.I1S296"/>
    <dbReference type="EnsemblFungi" id="CEF87599">
        <property type="protein sequence ID" value="CEF87599"/>
        <property type="gene ID" value="FGRRES_10882"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10882"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20705"/>
    <dbReference type="eggNOG" id="KOG0733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_8_3_1"/>
    <dbReference type="InParanoid" id="I1S296"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="246"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="545"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="131"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF87599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="781" mass="87712" checksum="423ED635AD4BE2E4" modified="2012-06-13" version="1">MDGKKVESLNLSTTESETENMTIGAKRPRPNLQKGLDRDVYLVLKKLEETNDGKPFKSTTAVYEAIKRSNSSLSRQKKRPLEDSIDRALQYRKEELGGDEDSSDSEAAFEEPPKPDDDRFLLNRQMTKHWHTPAQAPQDTAPQSTAPQIPSEAARVVKKRRVQEDGEERSGAVTPKGALTDTDAALAEKQEKTPFKKTPKSSRHKVEHPTDAVQIGGVADVYTELFKQTHGLLKWPELYASKNWRKVPGILLSGPAGTGKRSLIKFLASKIEVPIVSLTGCFEDPERLERSLNDAIEEAMRLAPCILFIEQLEWHMSNPGSKSHSDSQRRNVIQFMRQMRRIEAEQDKDRHILAMATTSRITDVDPAVLKTGLFERTVQMRIPDPEGREDILRLVTKNISLSEEVNFKELAKITHGFVGADIVNVLTIAEQEAAERHMDLSLCQQHLDQRFFTDQDQTLPDLMELENVLPSGLFPEPPVIPLTQEDFKKAIKNYVPSLRKDGFTVVPNITWDQVGALQAARKQLELSIIGPIRDPDRYRRHGLRRPAGCLLWGPPGCGKTLVAQAVANEAQASFILINGPELLNKYVGESERAVRELFNRARSSTPCILFFDEMDSLVPNRDKTSNEASTRVVNALLTELDGVQDRTGVYVIGTTNRPDMIDPAMLRPGRLSISLFLDLPSPNERVDILRAIYRTCHPDAAAAELERLEAVAHDPRCTDFSGADLGGLHEKAAESSLQREEEKADMGIDEVDWEYALSRSYKSVTNPETYRKMEAKMKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1S3S5</accession>
    <accession>A0A098E2X3</accession>
    <name>I1S3S5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG11471.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T22147</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325745.1">
        <property type="nucleotide sequence ID" value="XM_011327443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S3S5"/>
    <dbReference type="STRING" id="229533.I1S3S5"/>
    <dbReference type="EnsemblFungi" id="CEF87977">
        <property type="protein sequence ID" value="CEF87977"/>
        <property type="gene ID" value="FGRRES_11471"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11471"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22147"/>
    <dbReference type="eggNOG" id="ENOG502SQ6R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042941_0_2_1"/>
    <dbReference type="InParanoid" id="I1S3S5"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF87977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="264" mass="30386" checksum="2BEE7E084309DFDD" modified="2012-06-13" version="1">MESLYHPLTEHDELNAGEKRVLDSPFDRHIRIPSHYRRYLQHPYLVWVCHGILLSLSLVFFVSSLVLRANIHSSVGSTLPTFPYSPAAEVADFHTVRYNITPETKKTEFIGFGPDVDKAWDHVTYDVGDQMITRDELDNLGLDPSSLTIKDPKTGKTGYRVGIQVFHQLHCLNLLRQATHSDYYSHTGGDIDVEPEDLRGHLDHCIEFLRTNIMCQSDTGVFPFRYYDGYEGHWPDFSTLHTCRNFSAIREWAFEHAVVFGDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I1S4B7</accession>
    <accession>A0A098CZH2</accession>
    <name>I1S4B7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T00397</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF71998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315751.1">
        <property type="nucleotide sequence ID" value="XM_011317449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S4B7"/>
    <dbReference type="STRING" id="229533.I1S4B7"/>
    <dbReference type="EnsemblFungi" id="CEF71998">
        <property type="protein sequence ID" value="CEF71998"/>
        <property type="gene ID" value="FGRRES_11684"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11684"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00397"/>
    <dbReference type="eggNOG" id="KOG0068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_1"/>
    <dbReference type="InParanoid" id="I1S4B7"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050418">
        <property type="entry name" value="D-iso_2-hydroxyacid_DH_PdxB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="12"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="109"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF71998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF71998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="321" mass="35308" checksum="30F075D1CE6F93F5" modified="2012-06-13" version="1">MADSATKPELYILSDFHPEAVKYAQRSFDCILYGDPRTKNWHPHATAILIKDYYITEDDLASAPQLRVIGKQGVGLDKIDVEACKRHNVKVCNTPGVNASAVAEMTLCLALTVAREVPDVVIRQKIQGEAIRKETVAGMLLSRKIIGVVGMGHIGQAIAQMFVGGLQAEIIAFDPYFHDNQGPWDTIPYKRVETLTELLEVADVVTLHVPLTHSTKNMIAAPQLKQMKKTAILINTARGGIVNEEDLADALDKGEIWGAGFDCHCEEPPTLAKYERLWNCPRFVGTPHIAAATDETQIATINGATDGILQFLRDNKKSVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I1S4C6</accession>
    <accession>A0A098D261</accession>
    <name>I1S4C6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FGRAMPH1_01T00451</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315774.1">
        <property type="nucleotide sequence ID" value="XM_011317472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S4C6"/>
    <dbReference type="EnsemblFungi" id="CEF72026">
        <property type="protein sequence ID" value="CEF72026"/>
        <property type="gene ID" value="FGRRES_11693"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11693"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00451"/>
    <dbReference type="HOGENOM" id="CLU_180198_1_0_1"/>
    <dbReference type="InParanoid" id="I1S4C6"/>
    <dbReference type="OrthoDB" id="5095902at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_011316940.1">
        <property type="nucleotide sequence ID" value="XM_011318638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S4Z0"/>
    <dbReference type="EnsemblFungi" id="CEF73254">
        <property type="protein sequence ID" value="CEF73254"/>
        <property type="gene ID" value="FGRRES_11908"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11908"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02905"/>
    <dbReference type="HOGENOM" id="CLU_144934_0_0_1"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF73254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73254"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="111" mass="12812" checksum="18CD074E29AC66E8" modified="2012-06-13" version="1">MGQLYDMVHSTICGREDYSAWYRVSWGKPRDSYQIEDHKEVLQLLRETNVVVAFSRERQYYPDFDCGPWDIVSVRGAFRRVVGMAMIDGHIKHEAIGDGRVTSGWQGSQGR</sequence>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_011317216.1">
        <property type="nucleotide sequence ID" value="XM_011318914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S529"/>
    <dbReference type="EnsemblFungi" id="CEF73546">
        <property type="protein sequence ID" value="CEF73546"/>
        <property type="gene ID" value="FGRRES_11947"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11947"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03481"/>
    <dbReference type="eggNOG" id="ENOG502RZXZ">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_022899_0_0_1"/>
    <dbReference type="InParanoid" id="I1S529"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
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        <property type="component" value="Chromosome 1"/>
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    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
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        <property type="entry name" value="BLL5714 PROTEIN"/>
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        <property type="entry name" value="BLL5714 PROTEIN"/>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_011319118.1"/>
    </dbReference>
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        <property type="gene ID" value="FGRRES_11975"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03909"/>
    <dbReference type="HOGENOM" id="CLU_076400_0_0_1"/>
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        <source>
            <dbReference type="EMBL" id="CEF73761.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    <sequence length="316" mass="36618" checksum="DF02461197DBA61A" modified="2012-06-13" version="1">MSINIVGTTYLTRPTRVISDNTALPKWSQRQVGRFNAGSTQEVFQDLAFPSSIIHLPSSIFHLPYSIIHLSSFIITSIHITFQQAHSVSKVSYQNPHKMATPTKIVHEWWGSLNEEVESRDVQPSAEIRKQMKHIKNFFFAKLIDWPDHDLRTKHVFSHGSCIYVRAPDNGRIPIAEAKKDYLVTKDAHRNSTPDADHAVQWAIFIFDSPLSLLMFAKTMRVRFSPTTTLTLQLHLFHLKHLPRVACSLGAVREALRDQLEEWKVALKALRPKLNLKLRLVLGQENETLFDLDIETEEFRKERMEYLKEMKVLWLE</sequence>
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    <accession>I1S6Y1</accession>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323201.1">
        <property type="nucleotide sequence ID" value="XM_011324899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S6Y1"/>
    <dbReference type="STRING" id="229533.I1S6Y1"/>
    <dbReference type="EnsemblFungi" id="CEF87557">
        <property type="protein sequence ID" value="CEF87557"/>
        <property type="gene ID" value="FGRRES_12604"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12604"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16249"/>
    <dbReference type="HOGENOM" id="CLU_109903_0_0_1"/>
    <dbReference type="InParanoid" id="I1S6Y1"/>
    <dbReference type="OrthoDB" id="3932329at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF87557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="267" mass="31009" checksum="25727E6607FC00CE" modified="2012-06-13" version="1">MANRFMKTSSNAKIHSLGDLWLVLERRCICHIWAESSNDWADGESRFIPEIPHAETGVRSLDGYYVPRSCLLRTGDEWEGWWDEDPFDILDLTADLMTNLERLEPTPNSMFRNLFELLPNEIKNHVCSYLQDEELSLDCTYLMPQFMWAGMFFRIAFLWDLDVKVVYKKTGSSKVDLEKWNWEKLTRQVMSRAESSLNAKSGVKESAWDYSKVELHVPGGLANRRRIWQVLEEMLPSTAVWEGPNEPYTDAMLELAHNEVGGPINPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I1S798</accession>
    <accession>A0A098E2M2</accession>
    <name>I1S798_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
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    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T17717</name>
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    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323881.1">
        <property type="nucleotide sequence ID" value="XM_011325579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S798"/>
    <dbReference type="EnsemblFungi" id="CEF88360">
        <property type="protein sequence ID" value="CEF88360"/>
        <property type="gene ID" value="FGRRES_12721"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12721"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17717"/>
    <dbReference type="HOGENOM" id="CLU_2264021_0_0_1"/>
    <dbReference type="InParanoid" id="I1S798"/>
    <dbReference type="OrthoDB" id="10271761at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF88360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="103" mass="11569" checksum="C0F7DF525C429457" modified="2012-06-13" version="1">MCSKIAAWGLPATEERAVLRNIAAWSMPFLALNVLYSDHLYSSIVWMDGWLAFDRKHMLKGDVDRILVLQPCGETWQARGELRGQRLENGSSVVDAFPLSPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I1S7M7</accession>
    <accession>A0A098E0Z1</accession>
    <name>I1S7M7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T19239</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324607.1">
        <property type="nucleotide sequence ID" value="XM_011326305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S7M7"/>
    <dbReference type="EnsemblFungi" id="CEF87267">
        <property type="protein sequence ID" value="CEF87267"/>
        <property type="gene ID" value="FGRRES_12850"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12850"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19239"/>
    <dbReference type="HOGENOM" id="CLU_1482106_0_0_1"/>
    <dbReference type="InParanoid" id="I1S7M7"/>
    <dbReference type="OrthoDB" id="10306932at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF87267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="182" mass="19911" checksum="C8FB2EC09CCEF2C4" modified="2012-06-13" version="1">MSILIFPINPGSVSSCQPREPTPWPCSCQTGLCLGCFEFGDSLYLLFPEGWVDSQGYILSHGIPALHASTRGGFGQDVTFSHSSGNVTEARIYNEERSFIRSSIDVAFDITRCLTASPVIENWLKAMSGRRVDGVGADVYLWVLWHGLSRVSMISKTRGFARDRFLPNYLPAGGMLGSTGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1S7U7</accession>
    <name>I1S7U7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG06458.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T22325</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326058.1">
        <property type="nucleotide sequence ID" value="XM_011327756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S7U7"/>
    <dbReference type="STRING" id="229533.I1S7U7"/>
    <dbReference type="EnsemblFungi" id="CEF83836">
        <property type="protein sequence ID" value="CEF83836"/>
        <property type="gene ID" value="FGRRES_12922"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12922"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22325"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_11_1"/>
    <dbReference type="InParanoid" id="I1S7U7"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="78"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="447"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF83836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="562" mass="60931" checksum="A24FFA20E00CE8EF" modified="2012-06-13" version="1">MAIDASTANLDRTQIVPLHGGPHVLPNNPLFTRLLRHAHRNYLAIRDRELGVSKTYGELLDAVLGLRDVVRAALPSEVIEQLNNGNEVYVGVLAAGGYEFTVAVLAVLALGAAVVPMFPTAPVDEIVYYATKSQQVAILSSSATTQLAQESAQCCGIAQLNILPNLPRTPRFEPPDISLSSNPPQDPSAPGVVIFTSGTTGKPKGVVLRRTYTHEGAITVGDSYGITHTDVLLHTLPVHHQTGLGTSFFPFLNAGACIEFHGKFDAATVMQRWLQGGLTVFSAVPTIYMRLKWFIEQLPAQEQAPYKQSATQFRAFLCGSSALQEHVQEFWAAEMGRPILARYGATEIPGCIRVSVELRDIPKGSVGQPLPGVEAKISPEGELLVKTPNMFAKYLMEPETTKNAHDADGWYKTGDIARREGNFYFIVGRASVDIIKSGGYKISALDIERACLALPYVNEAMVVGVEDDEFGQRVGAVLALKNAKASDVTLAKVRSDLRGQLAGYKLPTLLRVVEGELPKGATGKVQKKILGPKLIPSPGYEKIPQVQVWKNPRQAGRVQARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I1S7W4</accession>
    <accession>A0A098DRQ2</accession>
    <name>I1S7W4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FGRAMPH1_01T22605</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326181.1">
        <property type="nucleotide sequence ID" value="XM_011327879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S7W4"/>
    <dbReference type="EnsemblFungi" id="CEF84541">
        <property type="protein sequence ID" value="CEF84541"/>
        <property type="gene ID" value="FGRRES_12939"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12939"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22605"/>
    <dbReference type="eggNOG" id="KOG3824">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_053737_0_0_1"/>
    <dbReference type="InParanoid" id="I1S7W4"/>
    <dbReference type="OrthoDB" id="439046at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Fido-like domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
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    <dbReference type="PANTHER" id="PTHR13504:SF38">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN DDB_G0283145"/>
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    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
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            <begin position="238"/>
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        <location>
            <begin position="1"/>
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            <begin position="1"/>
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        </location>
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        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="54"/>
            <end position="68"/>
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    <feature type="active site" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="336"/>
            <end position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF84541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="412" mass="47038" checksum="7E3866335CAFB066" modified="2012-06-13" version="1">MEHPSDRKRKRKPLGNIFGNDPQPTSDTSSATPSSPFKRNRKRKPLGNLFGNDPQSTSGTSSATPSSPVKRTKLLEDFQKSVRQNWPAMQAVPITIRADSIYRTYATGQDPKTLFDKATRYLQTVKDSRTPKQQAILVERLHESIIHAIFGSNKIERAGLGLDVTVHLCRKILRGEPVPEIEECDPHYELELAELYDLDHTLHHENRQHVLRGRREIVQHVRAFQHIIHHFVVLREDMTEDLIKKTHAILCKGVSIIDPELPEVPSEEYAGKYRDVWVSAGDTTFVAPELVPAKMTEMCADMKKEIDDCEAQGSIDPFSIASKYSLEFVQIHPFEDGNGRMCRMILNAILFRYAGIVVPIGEREEERDEYLDIKVRASEKMEGHGEYATFVLEKGMTSIRWLKRKLRGKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1S9T6</accession>
    <accession>A0A098DSQ4</accession>
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        <submittedName>
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        <name evidence="9" type="primary">FG09652.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T26585</name>
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    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
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        <property type="protein sequence ID" value="CEF83858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328054.1">
        <property type="nucleotide sequence ID" value="XM_011329752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S9T6"/>
    <dbReference type="STRING" id="229533.I1S9T6"/>
    <dbReference type="EnsemblFungi" id="CEF83858">
        <property type="protein sequence ID" value="CEF83858"/>
        <property type="gene ID" value="FGRRES_13617"/>
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    <dbReference type="KEGG" id="fgr:FGSG_13617"/>
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        <property type="component" value="Chromosome 4"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
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    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
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        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF16">
        <property type="entry name" value="D-AMINO ACID OXIDASE (AFU_ORTHOLOGUE AFUA_5G11290)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
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    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="5"/>
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        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF83858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="361" mass="39575" checksum="BA1A5E34305603AB" modified="2012-06-13" version="1">MANTIIVVGAGVSGLTSAYLLSKNKGNKITVVAKHMPGDYDIEYASPFAGANVCPMATQENSRWERRTWVEFKRLCEQVPEAGIHFQKCHIARRKKDVEEAKSSTFPDALFQEEPWYKELFEDFREQNPNEVTRGYDSGCEFTSVCINTAIYLPWLAGQCLKNGVVLKRTSLTDISEAKKLSHTGKVPNIIVNATGLGSLKLGGVKDETMAPARGQIVVVRNESTPMLITSGVEDGGSDVMYLMQRAAGGGTILGGTYDVGNWESQPDPNIAQRIMQRIVEARPEVADGKGVKGLSIIRHAVGLRPWRKGGLRLEEEKLDDETWIVHNYGHSGWGYQGSYGCAEGVVELVDKVGKGAKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I1SA11</accession>
    <accession>A0A098DAA8</accession>
    <name>I1SA11_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
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        <name evidence="3" type="ORF">FGRAMPH1_01T07125</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318960.1">
        <property type="nucleotide sequence ID" value="XM_011320658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1SA11"/>
    <dbReference type="EnsemblFungi" id="CEF75367">
        <property type="protein sequence ID" value="CEF75367"/>
        <property type="gene ID" value="FGRRES_13692"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13692"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07125"/>
    <dbReference type="eggNOG" id="ENOG502RKPM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047274_0_0_1"/>
    <dbReference type="InParanoid" id="I1SA11"/>
    <dbReference type="OrthoDB" id="5102015at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124874" evidence="2">
        <location>
            <begin position="22"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="117"/>
            <end position="143"/>
        </location>
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            <end position="99"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF75367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="499" mass="53891" checksum="9846AD3C5117D01E" modified="2012-06-13" version="1">MVSVKLFTVLVTASGLWAVHAGKCKPHTSFLTLTSGASTTTSFSSSYFKSTDDEVDVASSTEHPTSTDSVETISSGMSASSATTLDQPTAPGSSLSDPTATIDSTVSSDDIVIDVSTFSSSPTTDTGDINASTGSDAPHEASVSTGLTTFIEKTTTDTATSAQSTSAEIIDTTETIVTTETTTSMDATTTEFTTISALDSASTTENLWTSTTVVSCPVYSNLLDDPSFEGENNAPNRWELKLQFDGTAVTYQKQSSNSQDVPRAHSGDQFVLLGTNVGTDMRRVVSLDKKKYQLWITYAAISDPDEDWGFNFIVVTRNGHAFRQLTNVPKGEPFVYREESTVFQGWKDDFIQPFVRLNSGSKPRLVAIDDIYVAEYVPSCVMTTEKSELCGGIQGFVGNSAKSYRMVTFDQGDVEICAQLWNSISNPVVFSKKPKTNWELLLEREEEWCSTNGHVGNVPVLTACRLDIAKAQSQSDINNSAVACFMITRNGSVREKALL</sequence>
</entry>
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    <accession>Q4HVU7</accession>
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    <accession>V6RV02</accession>
    <name>ATM1_GIBZE</name>
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        <recommendedName>
            <fullName evidence="8">Iron-sulfur clusters transporter ATM1, mitochondrial</fullName>
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    <gene>
        <name evidence="8" type="primary">ATM1</name>
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        <name type="ORF">FGRRES_10911_M</name>
        <name type="ORF">FGSG_10911</name>
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    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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        </lineage>
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    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins (By similarity). Hydrolyzes ATP (By similarity). Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="8">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="SCB64970" version="1"/>
        </conflict>
        <text>Truncated N-terminus.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="DS231670">
        <property type="protein sequence ID" value="ESU17847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64970.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325469.1">
        <property type="nucleotide sequence ID" value="XM_011327167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4HVU7"/>
    <dbReference type="SMR" id="Q4HVU7"/>
    <dbReference type="FunCoup" id="Q4HVU7">
        <property type="interactions" value="688"/>
    </dbReference>
    <dbReference type="STRING" id="229533.Q4HVU7"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T20779">
        <property type="protein sequence ID" value="FGRAMPH1_01T20779-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G20779"/>
    </dbReference>
    <dbReference type="GeneID" id="23557791"/>
    <dbReference type="KEGG" id="fgr:FGSG_10911"/>
    <dbReference type="eggNOG" id="KOG0057">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_1_1"/>
    <dbReference type="InParanoid" id="Q4HVU7"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140466">
        <property type="term" value="P:iron-sulfur cluster export from the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000004">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000255446" description="Iron-sulfur clusters transporter ATM1, mitochondrial">
        <location>
            <begin position="24"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="1">
        <location>
            <begin position="24"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="1">
        <location>
            <begin position="183"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="1">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="1">
        <location>
            <begin position="278"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="1">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="1">
        <location>
            <begin position="400"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="114"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="439"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="682"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="283"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="346"/>
            <end position="349"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P40416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q2G506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q9NP58"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <sequence length="698" mass="77443" checksum="ED5E64D85A12EDC5" modified="2005-08-16" version="1" precursor="true">MIPQLLQRSSRACPRYNPALYRLSTTSQQRPGLTQTFWTSAPRREQPRTPTDSKPTTTKPSAVFPANKKATKQNDPLVTVEKSAPEQRKADWAIMKEMTRYLWPKDDWGTKLRVSLAVSLLIGAKVLNVQVPFYFKSIVDSMNIDVAAVGGTATTVAGAMILAYGASRIGATVFQELRNAVFASVAQNAIRKVACNVFDHLLRLDLTFHLSKQTGGLTRALDRGTKGISFILSSMVFHVLPTALEISMVCGILTYNYGAKFAALTVLTMVSYTAFTIWTTAWRTKFRRQANAADNKASTVAVDSLINYEAVKYFNNEKFEVARYDKALGQYEKNSIKVATSLALLNSGQNIIFSSALTGMMYLAANGVAEGTLTVGDLVMVNQLVFQLSVPLNFLGSVYRELRQSLLDMETLFNLQKVNANIKEKAGAKPLVLSKGGEIKFENVNFAYHPNRPILRDLSLTIPAGKKVAVVGPSGCGKSTLLRLLFRSYDVQGGRVLIDDQDIRDVDLESLRRSIGVVPQDTPLFNDTVEHNIRYGSINATHEEVVAVAKRAHVHNTIQSFPDGYETKVGERGLMISGGEKQRLAVSRILLKDPPLLFFDEATSALDTHTEQALMMNINSILRERGRTSVFVAHRLRTIFDSDLIIVLKEGHVAEMGTHRELIDRDGVYAELWSAQETMFGEDGKEKSEEENDEQKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>V6RK96</accession>
    <name>V6RK96_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="13">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">FG08350.1</name>
        <name evidence="15" type="ORF">FGRAMPH1_01T09731</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 13">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="13"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320433.1">
        <property type="nucleotide sequence ID" value="XM_011322131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6RK96"/>
    <dbReference type="FunCoup" id="V6RK96">
        <property type="interactions" value="455"/>
    </dbReference>
    <dbReference type="STRING" id="229533.V6RK96"/>
    <dbReference type="EnsemblFungi" id="CEF76668">
        <property type="protein sequence ID" value="CEF76668"/>
        <property type="gene ID" value="FGRRES_08350"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08350"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09731"/>
    <dbReference type="eggNOG" id="KOG2467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_0_0_1"/>
    <dbReference type="InParanoid" id="V6RK96"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF57">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 12 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="14">
        <location>
            <begin position="38"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CEF76668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="502" mass="55088" checksum="B80BB59CD560251F" modified="2014-02-19" version="1">MMNMRLLRQQCLRTKPSLATRISTRGFASQKDLLGSSLEQGDPEIHAILKREEKRQNHFINLIPSENFTSRSVLDALGSVMQNKYSEGYPGARYYGGNEHIDEAERLCQSRALETFRLDPEKWGVNVQPLSGSPANLYAYSAILNTHDRIMGLDLPHGGHLSHGYQIPGKKISMISKYYETFPYRLNEETGLIDYEKLRENALLYRPKVIVAGTSAYSRLIDYERMRAIANEAGAYLLSDMAHVSGLVAAGVIGTPFDDSDIVTTTTHKSLRGPRGAMIFYRKGVRSTDKKGKQIMYDLEGPINASVFPGHQGGPHNHTITALAVALKQAQTPEFKDYQEKVLANSQAMANQLTDLGYSLVSGGTDNHLVLVDLKPKGIDGARVERVLELVGVASNKNTVPGDRSALKPGGLRLGTPAMTTRGFNGEDFKRVADIVDRGVKITLAVDKDARAAAEAKGAKNPGTVKNFLEFLGDGSSVKEIAALRDEVAEWVGGFPQPWLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D057</accession>
    <accession>A0A0E0RKP7</accession>
    <name>A0A098D057_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T00045</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF71822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D057"/>
    <dbReference type="EnsemblFungi" id="CEF71822">
        <property type="protein sequence ID" value="CEF71822"/>
        <property type="gene ID" value="FGRRES_15677_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00045"/>
    <dbReference type="InParanoid" id="A0A098D057"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF71822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF71822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="95" mass="10086" checksum="87F4CEE55170D922" modified="2015-01-07" version="1">MPDRLKDGLANEVLDILDKAASSFNGFEVEHLANKNHEGLIGCLVGVQLGHVGTGNLEFEEAHVVAGGVDENGTMEVSDCESQGWSEQGYLSLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D2S6</accession>
    <accession>A0A0E0RNC7</accession>
    <name>A0A098D2S6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FGRAMPH1_01T01903</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A098D2S6"/>
    <dbReference type="STRING" id="229533.A0A098D2S6"/>
    <dbReference type="EnsemblFungi" id="CEF72752">
        <property type="protein sequence ID" value="CEF72752"/>
        <property type="gene ID" value="FGRRES_15777"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01903"/>
    <dbReference type="eggNOG" id="ENOG502SR2B">
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    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
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        </source>
    </evidence>
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    <accession>A0A098D3G3</accession>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="FGRRES_15800"/>
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    </evidence>
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        <source>
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        <source>
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    <accession>A0A098D679</accession>
    <accession>A0A0E0RRT5</accession>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D679"/>
    <dbReference type="EnsemblFungi" id="CEF73960">
        <property type="protein sequence ID" value="CEF73960"/>
        <property type="gene ID" value="FGRRES_01772_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04307"/>
    <dbReference type="eggNOG" id="ENOG502RPP3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098D679"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF73960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="333" mass="37096" checksum="C8933738B4035265" modified="2015-01-07" version="1">MVAAEIKDDLTRRRERGRRSQAAFRKRQAKSTQALTDQNCRLRNGVQLLLDEARGDERPEMLDILRDLADAADLNIPATLSSKASTTTTKLTNTTPEDFDTFKTSLVPSQIIDVPLNLKTFPAASTTQYRLDCSVWLDPLHYLRVSIPPQDLLPYIGPGAETFAGLLFWSVMEHSQSGCLRHDVVSNVKACLGHSSVTRDIKPTFIQTMARARIEYKKTGSISQEHAVAGEDDLGLVLCKLVEDDYRSNGKDPNQWLSCVSIEKRIKRAIGDYRLGFLTLAADGQANSTLHSLLEVVLCKLYDSSVCFGDGPRWDVKVVDQLFAPLIMQTLLV</sequence>
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<entry dataset="TrEMBL" created="2015-01-07" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D6B9</accession>
    <accession>A0A0E0RTB3</accession>
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        <submittedName>
            <fullName evidence="8">Chromosome 1, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
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            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
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        <property type="entry name" value="Zn_clus"/>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF74488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="682" mass="75708" checksum="6AFE8230BF0CA4E1" modified="2015-01-07" version="1">MEAPVEKTQQHQVACFSCRASRQKCDRQDPCSRCISHDRVCKYPARSNRGRKHGSTNKPDSVEKLLSRIEESGAKDEIIAALLGTGLPSPNRTVSVRGTPWTQAQSSTDSRATSQPAQPDSPTEDDEYNHPEDLISPLSIVTTAIATNTSIQCERLRSQMPMQPGVREAIMAPIKERLGAYFSSHRAQQKDWDVLAAQAVDCPFKLEKGTCDPLASRLIDDSDATVYFQLFFSTRNPLVGLLDATLHTVDYVYANSFTLFSVVCALGCAMSARPRDRAIYPVLMNLASGNVKWSIAAAVKSLATIQAIVNMQYWTPVSPTQVDDSSSISLSYAMQLAREMGISRSEVIREYVNAECENSPSENKGRCIRNFERTWLRTLIADKGFGIMNGKLHSVNWKEIPSSAAQWWKAPLAEPTDRMLSGIIEIRRLLLSQVDKRKQANSITSSIVEWHKESYDALTQLRNERCIKDDSPSAQLLPVLAFYMDHSILVLNAQALRDLAAAEDSTSPSSSEALLGIERKSIEVASRVLDLLSLDKTIIELALGFQNNQYLMICHVMTEVLRAIKRGALTPEENSAAAGKVIGVIPLLDQIVQLLPATSAAHLYFDLARFFACQIDSLMGAPDLQEMRETIDTGMFTDDWFKAMDTGMPDVYTLLDMGYLGMDQPMMDTDDFMALNDFNSIT</sequence>
</entry>
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    <accession>A0A098D7C9</accession>
    <accession>A0A0E0RSX2</accession>
    <name>A0A098D7C9_GIBZE</name>
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        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
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        <name evidence="1" type="ORF">FGRAMPH1_01T05083</name>
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    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D7C9"/>
    <dbReference type="STRING" id="229533.A0A098D7C9"/>
    <dbReference type="EnsemblFungi" id="CEF74347">
        <property type="protein sequence ID" value="CEF74347"/>
        <property type="gene ID" value="FGRRES_02108_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05083"/>
    <dbReference type="InParanoid" id="A0A098D7C9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009783">
        <property type="entry name" value="DUF1348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757">
        <property type="entry name" value="SLL0781 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757:SF0">
        <property type="entry name" value="SLL0781 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07080">
        <property type="entry name" value="DUF1348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF74347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="157" mass="18845" checksum="DF70E5C9F7FA1FBF" modified="2015-01-07" version="1">MSEQRPPFPPFSRESAHVKVKAAQDGWNTQNPSKVKMAYTPDSIWRNRGTFVKGRDEIEAFLTDKWNREHDYKLRKELFAFDNDKAMIQIAVQFWYEFRDDEGQWWRCYGLEDWTFDNDGLMKKRQMSGNNVKISEEERWFKEGVDVNTVEIGPEHW</sequence>
</entry>
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    <accession>A0A098D8H8</accession>
    <accession>A0A0E0RVH3</accession>
    <name>A0A098D8H8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T06887</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D8H8"/>
    <dbReference type="EnsemblFungi" id="CEF75248">
        <property type="protein sequence ID" value="CEF75248"/>
        <property type="gene ID" value="FGRRES_20087"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06887"/>
    <dbReference type="InParanoid" id="A0A098D8H8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF75248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="63" mass="7000" checksum="E4043231BC172ABD" modified="2015-01-07" version="1">MGTDGTDDDRSSASTMRFQSWSAAVLAAFRLFVPALEICQPVLYPASPPLRLWDEDKGRVTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DAC3</accession>
    <accession>A0A0E0RVV7</accession>
    <name>A0A098DAC3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG10047.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T07155</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DAC3"/>
    <dbReference type="EnsemblFungi" id="CEF75382">
        <property type="protein sequence ID" value="CEF75382"/>
        <property type="gene ID" value="FGRRES_17306"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07155"/>
    <dbReference type="eggNOG" id="ENOG502RYII">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DAC3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF75382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="613" mass="70024" checksum="21D6323DFA90C126" modified="2015-01-07" version="1">MSLLKLPIEIVSLLVELLDVEDVFNMALSCRFLSCILYDKRMCRLALMKAPYSAEAQQVQSSDDCPKAFRKLAKRRISVRGAEPWMVAIVAMADHFIYTNGHLCYTIENKHLRVLNTLQQISTAEMTVDVPLLLKLAVRDYDHLKPHTIEPLYFAEGVLSCLATQVLEDSTTCSWLIIFELKENPSWVVVQRPCSTHPIFVRNDKNYLFWGSRSHSTLEGSYRWGLHCLNLQTRKWSDSQLILWDFHEASIGSDICFEIIDGQFYCVSNMLKTRTERSVCNNFYQVVRFPVHDAAQERCEKPPMRNLWRRHDSEGLVDERWTSLQISKSEQTGKVSIVEIRKEWCPGNAGSQRTCYRRELEFGQQEANHSPESLLPTPPDSTEGSLAEEEWDSKAYMEERACDDFHVGDGPKDTKAYTLQECFVRSYNPSCNSFIDLVSEAYNPDSSLQLRVQPKEQGSSVRLWPRDQHSYHHDGVLSQLHSVVNPIQPIRGVEWSMDERILVYSPTHMASGQLRPLVLISFDPSFILPGFPNYGCCSGEMEYQLNDPPHMQDTNAIGAPNEMLSQSTQGDDEYSSASEEDQNTGSNFVKVRPSLYRTMNMGSGNAHGFNMSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DAL1</accession>
    <accession>A0A0E0RUP6</accession>
    <name>A0A098DAL1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
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    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T06333</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
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        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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                <consortium name="EnsemblFungi"/>
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            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
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            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="DOI" id="10.1038/nature08850"/>
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    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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        </source>
    </evidence>
    <sequence length="573" mass="63541" checksum="2731D056D046F79E" modified="2015-01-07" version="1">MKSESEQEKRREDKKEVDNGDEKTSLGPDEESQRPPTSGSTSSKSEHHVQQDTIEPVMLGEPLGHIDTRPSVKRAQSRASSAQSKTRSVVPRSQRRGLLARFTLVPEIEYPPDYKNSTKWCLTAIVALATAAAPLGSTVVYPALPILVDEFNTTETITNLSVALYMISMAIFPLWWSSFSEEFGRRTIYLISFSLFVIFSILSAISKNITMLIIFRMCAGGASASAHSTGAGSIADMFEVFERGRAMSIFYLGPLLGPMIAPVVGGALTQEIGWQATMWFLAIYGLVVLLMILFFLPETLQRKPEAVLPTADTQELSRMRTMDSAKIKTRNFAKSARRFLIDPLGVLLYLRFPPVLITVLLAAIAFGSLYVVNIAIQQKFSREPYNFGQLSIGLMYIPGGLGYIVGSLSGGRWIDKIMAREARKAGRYDEDGKLIYLPEDRMRENAWVMTTMYPLALLMFGWVLRYGLHPAVPCVALFLFGISSMLVFSVATTMLTELIRKRSSSGVAVNNFVRNTLSCTGAIVAAPWINAIGTGWVFTTLCICCLIISYICIFLLRKNATKWRKAMDKALGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DCG9</accession>
    <accession>A0A0E0RY22</accession>
    <name>A0A098DCG9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T08689</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF76147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DCG9"/>
    <dbReference type="EnsemblFungi" id="CEF76147">
        <property type="protein sequence ID" value="CEF76147"/>
        <property type="gene ID" value="FGRRES_17433"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08689"/>
    <dbReference type="InParanoid" id="A0A098DCG9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF76147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="387" mass="41314" checksum="188E1A3B8F668931" modified="2015-01-07" version="1">MSNVQVEEAMALMSKLTMEQIQGVMLANNEALNVAAMLNQPSPPLGSKTVKAIVEGWEGEQKVQFGQLAIRGCFKLSVDQVIHDGLKRNNVPQVYELHKTFPDGTQAWKGVSQMDILEKSTKYHEAVLKSSQKVGIPKTRADIQTHNLAKTALLRNAANAATLNMAATAMFDIKTLFNGDFQKYFVKLGISGMHGGAVAGIQARIHHSFFGNGAVVGVVVSSAFGVVGLVNTGDWARFGKNTGLGIVGSAGGWGGSQLGTMAGTFFVGPLGTIPGGIVGGFCGSLAGRWTADKTTNLAELTDLEVEHIYDNVKEGNAKMGLRVDPSLTKREVVARILDQRGDSVAVQMTDTMATDIATLQENLSDWQQGDPKDFEAFVEGLRKATSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DDU7</accession>
    <accession>A0A0E0S0V8</accession>
    <name>A0A098DDU7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T10661</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DDU7"/>
    <dbReference type="EnsemblFungi" id="CEF77133">
        <property type="protein sequence ID" value="CEF77133"/>
        <property type="gene ID" value="FGRRES_15504"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10661"/>
    <dbReference type="InParanoid" id="A0A098DDU7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF77133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="60" mass="6482" checksum="470A92EAF0BE19D1" modified="2015-01-07" version="1">MSVTATICVLKPAGKKKRLNINHLITPKLSILLFIHGILCPGANDIIEGLGGHSEVWPDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DG53</accession>
    <accession>A0A0E0S333</accession>
    <name>A0A098DG53_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG03164.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T12209</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DG53"/>
    <dbReference type="EnsemblFungi" id="CEF77908">
        <property type="protein sequence ID" value="CEF77908"/>
        <property type="gene ID" value="FGRRES_16316"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12209"/>
    <dbReference type="eggNOG" id="ENOG502RY2N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DG53"/>
    <dbReference type="PHI-base" id="PHI:5847"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF163">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_8G05510)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="41"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF77908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="363" mass="39850" checksum="6FF4D622026108E4" modified="2015-01-07" version="1">MSASGDWGPAPAGIDLTEDQDGEILRPVIALMTLGIIAVAIRLVARCKSGTGIAIDDFLIFLALIFALGTAALCITSIPFGGGKHLWVVTFSEFTVLWKLAYSFVLIYATTVTLTKASILLFYRRVFGINLAHRICMGLVLGYWVAITIAWVSGCRPASYFWEQFTDPDAEGTCINTSLFYFVNGICAMLIDIAILCVPIPTILKLRMPNSQKIAVAGILLVGAFVCIASIVRIFYMDKLVKAQDFTWAMAQVFIWSCCEPLVGIVCACLPTFGPLLRRWFRTVASTAEVNSNSNSWNPNKPRSQWKPYHGGFRIRQDDELELTVDVSHGNAQFEGQGGTGIHVQNEFTWADADGSVGSRKHS</sequence>
</entry>
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    <accession>A0A098DHX4</accession>
    <accession>A0A0E0S246</accession>
    <name>A0A098DHX4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
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    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T11535</name>
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    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DHX4"/>
    <dbReference type="EnsemblFungi" id="CEF77571">
        <property type="protein sequence ID" value="CEF77571"/>
        <property type="gene ID" value="FGRRES_20162"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11535"/>
    <dbReference type="InParanoid" id="A0A098DHX4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF77571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="64" mass="7095" checksum="63F0B993FA535088" modified="2015-01-07" version="1">MLVELIDSVDTAHNRIESFPAGHDLKLPGVQFIKTEIDPGQSVLSHGFELSVQSYSIRVYAKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DIY6</accession>
    <accession>A0A0E0S4G7</accession>
    <name>A0A098DIY6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FGRAMPH1_01T13177</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DIY6"/>
    <dbReference type="EnsemblFungi" id="CEF78392">
        <property type="protein sequence ID" value="CEF78392"/>
        <property type="gene ID" value="FGRRES_12415_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13177"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DIY6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF49">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="215"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="325"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="349"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="375"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="408"/>
            <end position="431"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="50"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF78392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="482" mass="52730" checksum="98355E96010D9265" modified="2015-01-07" version="1">MAARNDFDANPEMAGSQTDEKQNSDSRLENTIAVDPALEKALIRKQDARIIPLAAGIYLLCYLDRSNIGNAKVLNHTTGHDLLSETNMSNYDFTIALMIFLIAYALFEVPSNYFLKKMKPSRWIAFLMFSWGTITICLGAAHSFAVVTVLRFLLGVFEAGLFPGLVYYLTFWYKPEERSVRVATILASATLAGAFGGAIAYGVGHMNQVHGLSGWRWLFILEGIPSVLSSFLVWFCLPDFPESASWLSAEEKDVAAYRLAEQGSHGDSKSMTWEDAKSTILEWRLWCHYLIYFGISAPFSSLSLFTPSITAGLGFADLRAQLMTVPPYAAAYVVTLLVSWSADKYNARALHSAVFSLIGAVGFIASASLPADSYSPRYGCLIVAACGSFACIPPLLGWLSSNLHSTAAIGLAIALNISMGAPGQIVGVWIYKADEAAKGYPTGHWVNAGLLLFVTVGCLGMHAYYVWRNKRAAGTDQPRFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DJ27</accession>
    <accession>A0A0E0S4Q5</accession>
    <name>A0A098DJ27_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T13353</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DJ27"/>
    <dbReference type="EnsemblFungi" id="CEF78480">
        <property type="protein sequence ID" value="CEF78480"/>
        <property type="gene ID" value="FGRRES_20177"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13353"/>
    <dbReference type="InParanoid" id="A0A098DJ27"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF78480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="64" mass="6758" checksum="82CE07BDE5DD8CCE" modified="2015-01-07" version="1">MAPKPDSFRSILVSGTIYAVLITGVQMVYFPNGINPPKDTKESKESKESKESGPPSSSAPDGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DLE3</accession>
    <accession>A0A0E0S5J1</accession>
    <name>A0A098DLE3_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="6">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FGRAMPH1_01T13927</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="6"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DLE3"/>
    <dbReference type="FunCoup" id="A0A098DLE3">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A098DLE3"/>
    <dbReference type="EnsemblFungi" id="CEF78766">
        <property type="protein sequence ID" value="CEF78766"/>
        <property type="gene ID" value="FGRRES_16187_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13927"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DLE3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF116">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE (CYTOCHROME) (AFU_ORTHOLOGUE AFUA_7G02560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="8">
        <location>
            <begin position="133"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF78766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="560" mass="60893" checksum="6910CF04FEA61FB6" modified="2015-01-07" version="1">MSVLFKVLRSTRTGRSTSAIRLSSQQFRSSVSTSTASYKNGSVYRTGAYMLGLAVVGAGCAATTIDWSKRPSLSSTQPLTSTPTIQHNITAANIRAATKEFAALLGAENVSTDQADLITHSGSDYQSYAWTKEHAICSNVILYPETTEQVSELMKICSRRRLPVTPYSGGTSIEGQYIPHFRGICIDFGRMSSIVELNKDDLDCVVQPGIGWMDLNEELATHGLFFPPDPGPGAMIGGMVGTGCSGTNAAAYGTMKDWVLSLTVVLADGTVIKTRQRARKSSAGYDLTRTFIGSEGTLGLITEATLKLAVKPPCEAVAVCTFPSLRDAAFAVRDVLSAGIQVAAVEILDDVQMKSINESALTSIKWKEEPTLFFKFTGSDDFIVEHVAKKVGVITKQNRSTAYTFASDETERNELWSARKNALWSMLAMRKSPTDKVWTTDVAVPMSRLPDIIDFAKDDIEKSGLVGSIVGHVGDGNFHTLLLFPEDKRQVAEDIVHRMVGKAIEMKGTATGEHGVGLVKRDYLEKELGKDTVDMMRSMKNAFDPMCILNCDKVIRMQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DP96</accession>
    <accession>A0A0E0S9T1</accession>
    <name>A0A098DP96_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FG09611.1</name>
        <name evidence="13" type="ORF">FGRAMPH1_01T26673</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="gene ID" value="FGRRES_17244"/>
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</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DQH0</accession>
    <accession>A0A0E0SB01</accession>
    <name>A0A098DQH0_GIBZE</name>
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        <submittedName>
            <fullName evidence="5">Chromosome 4, complete genome</fullName>
        </submittedName>
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        <name evidence="6" type="primary">FG09120.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T27879</name>
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    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DQH0"/>
    <dbReference type="EnsemblFungi" id="CEF83614">
        <property type="protein sequence ID" value="CEF83614"/>
        <property type="gene ID" value="FGRRES_09120_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27879"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DQH0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
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    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="364"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="442"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF83614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="547" mass="61038" checksum="BA44954605BE7D81" modified="2015-01-07" version="1">MACSLPKDVSLYRKFTQRPINRYNSYGPPFDIPITITDRDGSLIHEQEGEALLTAIIAQDDVEFLERYFSIDPRAIPNPFGLPDDDEAICYHADRFNYAAKCGSLRILQMLFKYATKGLDKTKPVRLERANFQLLNVAAQYGQIEIVQWLLDTKPLYAGIHDRDLRGFTALAAAADLFPFRCAPAWHEICFNNNEAIMNLLLDHGACAADVVHPTGCMDQKRPTVLTLAAQWASSDLLGRLIDGGADVHYKVLSNSWELKFRDQRDFPVQIEVNALFLASFRANRDGVKTLVDRRGDEVDITDMVCSPDCVGSLPLHWASRNQLPDKIRLMPTSMLQERAGKITRTIEQLLHFAPATTNVQDNDGNTALHYATRYLGKNGKMYTPVFELLCSRGTDASLRNYKYQTPLHTLFEVQSDDGPIDPAAISLLLAHGAKVTDVDDAGNTPLHLATRSWHFVDAVSFLLEHGADPSQRNLKRENALHTAARGVCPGNGEETTEMSGNMIARLLKAGGVELMDVPNTDGKTARQICQEQDHEEIEDKEVTDVN</sequence>
</entry>
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    <accession>A0A098DSW4</accession>
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        <submittedName>
            <fullName evidence="1">Chromosome 4, complete genome</fullName>
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        <name evidence="1" type="ORF">FGRAMPH1_01T27491</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DSW4"/>
    <dbReference type="EnsemblFungi" id="CEF84970">
        <property type="protein sequence ID" value="CEF84970"/>
        <property type="gene ID" value="FGRRES_15541"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27491"/>
    <dbReference type="InParanoid" id="A0A098DSW4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF84970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="92" mass="9998" checksum="DF21F7EC969E9D04" modified="2015-01-07" version="1">MCNLTLNPVSLGPEHGSRIWRGGGETRRSESFDDNIDINGYHRGTVGITVDADGVGHLELPPTWTDSALVEIVAPQTLLASFLRVSTTHEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DV37</accession>
    <accession>A0A0E0SE50</accession>
    <name>A0A098DV37_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromosome 4, complete genome</fullName>
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    <gene>
        <name evidence="12" type="primary">FG09219.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T27637</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DV37"/>
    <dbReference type="STRING" id="229533.A0A098DV37"/>
    <dbReference type="EnsemblFungi" id="CEF84713">
        <property type="protein sequence ID" value="CEF84713"/>
        <property type="gene ID" value="FGRRES_17179"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27637"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DV37"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CuRO_3_MaLCC_like"/>
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        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
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        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF145">
        <property type="entry name" value="LCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="77"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="203"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="434"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF84713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="585" mass="65130" checksum="92CF6B1C3ED1D977" modified="2015-01-07" version="1">MGNTNSNQFNLGALGQLSQLQTNGESTYGTLDAPDLPTFLTDNPTPNGYPWSTMNTRTNYYQDHPNTGVIRKYDFTVNRAKIAPDGYELSTILVNGQFPAPLIEANWGDTIQVTVHNELEDEGLSLHWHGILQKNMPWEDGVPGVTQCPIAPGQSYTYSFIADLYGTSWYHSHYSAQYLAGLFGPLVIYGPQERKDYDIDVGPILLSDWYHKEYFDLVEEIMTPGAPGIVFSDSNLINGKMNFNCSSVQPGDKTPCKNNAGISKFRFRRGKVHRLRLINPSAEAIQRFSIDGHTMTVIANDFVPVEPYNTKVVTLGIGQRTDVLVKGNGKLESYWMRSNISANCSLARAHDALAAIYYDNANPKKEPKSKPWNIPDPATCANDDLSMTRPLMKLPLPPADKTIELDIASFKNASNITLWSLGGVAARTNYNSPTLLLSKLGNHTFDKEWNVINTGKAKSVRVVVNNKTPVAHPMHLHGFNMYVLHEGLGDWDGTIINEHNPQRRDVVQIRGRGHLVIQFDAGSNPGVWPFHCHIAWHVSAGLLAQFLTNPDQVEKLRIPNVVAETCRQWGHWTLSNIPAQIDSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DYF7</accession>
    <accession>A0A0E0SIU4</accession>
    <name>A0A098DYF7_GIBZE</name>
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        <submittedName>
            <fullName evidence="8">Chromosome 3, complete genome</fullName>
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    </protein>
    <gene>
        <name evidence="9" type="primary">FG11144.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T21321</name>
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    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DYF7"/>
    <dbReference type="EnsemblFungi" id="CEF86357">
        <property type="protein sequence ID" value="CEF86357"/>
        <property type="gene ID" value="FGRRES_13848_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21321"/>
    <dbReference type="eggNOG" id="ENOG502SFXF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DYF7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
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            <dbReference type="PROSITE" id="PS50103"/>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF86357"/>
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    <accession>A0A098E144</accession>
    <accession>A0A0E0SLK4</accession>
    <name>A0A098E144_GIBZE</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098E144"/>
    <dbReference type="EnsemblFungi" id="CEF87317">
        <property type="protein sequence ID" value="CEF87317"/>
        <property type="gene ID" value="FGRRES_15657_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22247"/>
    <dbReference type="InParanoid" id="A0A098E144"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF87317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="147" mass="15052" checksum="4373AF5CE57F5CED" modified="2015-01-07" version="1">MTSLAQSSKQSGFPPSAPLSPSLVTATKILSIVRIATGGACLFAPQLTCSLHGYYVPAPYALLVRMMGAREAINGALLFTASDGKESDGGNRNIRRALWVGILADSMDICSVLYGFAMGEVGTSTAGILGTAAAGAITIAALMLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098E337</accession>
    <accession>A0A0E0SNL4</accession>
    <name>A0A098E337_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
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        <name evidence="1" type="ORF">FGRAMPH1_01T20245</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
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                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
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                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098E337"/>
    <dbReference type="EnsemblFungi" id="CEF88027">
        <property type="protein sequence ID" value="CEF88027"/>
        <property type="gene ID" value="FGRRES_15349"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20245"/>
    <dbReference type="InParanoid" id="A0A098E337"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF88027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="85" mass="8888" checksum="1BC3E953EA0E7734" modified="2015-01-07" version="1">MASEMSHLVLESLGSHVDISLSPALAGITGGRGVPGSISHSCSCSYDDDDLLVRDYLNLAVTLTLDDAVQFAARPLNVDVLSSVQ</sequence>
</entry>
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    <accession>A0A0E0RRW8</accession>
    <name>A0A0E0RRW8_GIBZE</name>
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        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
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        <name evidence="2" type="primary">FG01804.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T04373</name>
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    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RRW8"/>
    <dbReference type="STRING" id="229533.A0A0E0RRW8"/>
    <dbReference type="EnsemblFungi" id="CEF73993">
        <property type="protein sequence ID" value="CEF73993"/>
        <property type="gene ID" value="FGRRES_15001"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04373"/>
    <dbReference type="InParanoid" id="A0A0E0RRW8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016814">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052349">
        <property type="entry name" value="Metallo-hydrolase_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32027">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32027:SF0">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF73993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="456" mass="51471" checksum="9DDD383407B1DDF4" modified="2016-04-13" version="1">MSLKSVILPLQDPKSQWDIEIEDSIVVSMKPSSHPSPNPGLLLPSLCHPHIHLDKPYLLNCNNSCSKNYPDYSDLLPKSGSFDEALANTAEAKKRYTADDLYLRGSQLLATSYAQGVTCVRGFVEIDHVTQLEPLKTAIQLKREFKGFLELQICAFAQDPIFSTEHGDENRAILTNALEEFGEYIDVLGTTPYVEDDFDWSKMNVEWAILMAQRCNLSLDFHTEFNLDRGDIMELFDYTVDQLVDKGWPTHSGAPTVVLGHATRITQASHEQLRGFSDRLRDTRLPVHFVGLPTSDLFMMSRPVTDDVSEQNKPLRRQCGTLNVPKMIQEYGFKACLSVNNVGNSFTPFGTGDPLGIASWGVGLFHAGKVDDAKLLYEAVSTRAMDAIKPAVVTHESKNHMDEEKRMMPMLLFKNRESMEIQSPQGRVIQLPARHRLSIKDIVWDPPEIRLRRVIR</sequence>
</entry>
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        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
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        <name evidence="5" type="primary">FG10266.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T07685</name>
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    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RWM1"/>
    <dbReference type="STRING" id="229533.A0A0E0RWM1"/>
    <dbReference type="EnsemblFungi" id="CEF75646">
        <property type="protein sequence ID" value="CEF75646"/>
        <property type="gene ID" value="FGRRES_17335"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07685"/>
    <dbReference type="eggNOG" id="ENOG502QVBS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0RWM1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="662"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="686"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF75646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="795" mass="88151" checksum="5D0E859289DB17FD" modified="2016-04-13" version="1">MTSKHPLRRSCAFCRARKIKCSNETICEACRKQGVDCIYDFESPRAKGRNLSFDGSKSNNLLQVRSDHDLPESKRRRSCSANSASSMSPRRAHEDLVPLGDGVESLAASLEQVFQDRFSQMVFGEASRVDLQATRNKSRCIGLLPLVACDLVGSVGQGYSILGACQPDDSNSQLIRSGLSNDKTSSMFDNNASYCSSPISTFSHRQRNQLIDVWYSAHPLTFLISKTLLLREMREDTCDEILIAVMLADASFVIGEAPMVTRGHELLQWAKAQLQMRPNHALEENDAVYSGVPTRVYKGVTTAQTLVLLAWNALSTNEFRRAVCYIQVASKMVTQIKDCMSKDVSPPSSSRINGVDVLDVEKEVVSNLWWTTFSLNLWMSIQAGVSPDASLSNFTHDSLPATENSSVSIQLDLVSENFNTLQKQKRNIREMRPLAHIVNTVAYLFSQSDQIASKHGLNACREAMREVESSNTKRSNQGDQPDESRHLIVAFHQTMIIQLLFPKNGPFYDQVIIPTDTLHQFCSSLEHIIRSLSPTSGQLDHHATPASSIQEPLSKSLCNLLDACSRAFSLVSENLGLGLDPSYFRPDWDSRLCSLASSLYSISKTSSFYQTTSLRNVRKQLKACIRAFSGQDSSNALGLLDPRMNNIRSLSHSPRNEAPNTFIVTDDSSTDIPSPFRYAEGDPRLSSSMPSSSASSTSVSTQSFTPFEEMTEWNVGENYSPGVMNTGNLSSPTVVHSGLQNGTPMQNVWYSQPTHMLNFQAAGPASMQNNQWVWPSTRAEDTTYMSFQALDMEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0S502</accession>
    <name>A0A0E0S502_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG03721.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T13547</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0S502"/>
    <dbReference type="STRING" id="229533.A0A0E0S502"/>
    <dbReference type="EnsemblFungi" id="CEF78577">
        <property type="protein sequence ID" value="CEF78577"/>
        <property type="gene ID" value="FGRRES_16217"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13547"/>
    <dbReference type="eggNOG" id="ENOG502SKH5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0S502"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF78577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="305" mass="34481" checksum="F013923159270026" modified="2016-04-13" version="1">MASIVFVTGATGRQGSAVARQLLDIGWTVRATARNMESPKAKELQNIGVELTPGDWDNEETLKKVIEGCTHVFLNVVPNLATFTSEVPHAKRILDMAKLTGVKHVVYSSGMAIKDLEKGPYHNPEHPVCRGHCWKRDIENLVQESGFDAWTILRPGFFMCNMLDPKVNMMYPDLVPQGILKTAYTPETRLPQVDVEDIAKFAVAAFREPERFNHQFVPIASEKLTLAEITKQLGEATGRSFRTTFITDEEIEEKMATDFFIAIQVMARELEDKVDIEDVQGWGIPLTSFEEFLEREESWVKSTYL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-10-02" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0S977</accession>
    <name>CHS8_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitin synthase 8</fullName>
            <ecNumber evidence="7">2.4.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Chitin-UDP acetyl-glucosaminyl transferase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Class-VIII chitin synthase 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CHS8</name>
        <name type="ORF">FG06550</name>
        <name type="ORF">FGRAMPH1_01T22563</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2016" name="Fungal Biol." volume="120" first="764" last="774">
            <title>Chitin synthase gene FgCHS8 affects virulence and fungal cell wall sensitivity to environmental stress in Fusarium graminearum.</title>
            <authorList>
                <person name="Zhang Y.Z."/>
                <person name="Chen Q."/>
                <person name="Liu C.H."/>
                <person name="Liu Y.B."/>
                <person name="Yi P."/>
                <person name="Niu K.X."/>
                <person name="Wang Y.Q."/>
                <person name="Wang A.Q."/>
                <person name="Yu H.Y."/>
                <person name="Pu Z.E."/>
                <person name="Jiang Q.T."/>
                <person name="Wei Y.M."/>
                <person name="Qi P.F."/>
                <person name="Zheng Y.L."/>
            </authorList>
            <dbReference type="PubMed" id="27109372"/>
            <dbReference type="DOI" id="10.1016/j.funbio.2016.02.002"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 7">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer (Probable). Participated in the development of cell wall and plays a critical role in fungal response to environmental stresses (PubMed:27109372). Necessary for pathogenicity and deoxinivalenol (DON) production (PubMed:27109372).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Reduces the chitin synthase activity and subsequent chitin content (PubMed:27109372). Leads to enhanced sensitivity to stress agents including acid, salt, and oxidant environments (PubMed:27109372). Reduces the production of deoxinivalenol (DON) and causes much less disease on flowering wheat heads (PubMed:27109372).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the chitin synthase family. Class VIII subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="7"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF82990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0S977"/>
    <dbReference type="STRING" id="229533.A0A0E0S977"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T22563">
        <property type="protein sequence ID" value="FGRAMPH1_01T22563-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G22563"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22563"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0S977"/>
    <dbReference type="PHI-base" id="PHI:6119"/>
    <dbReference type="PHI-base" id="PHI:6186"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF13">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000460799" description="Chitin synthase 8">
        <location>
            <begin position="1"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="583"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="27109372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="27109372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="27109372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF82990"/>
        </source>
    </evidence>
    <sequence length="668" mass="76289" checksum="FD93747C8495ECEA" modified="2016-04-13" version="1">MTSRMPTSGHRTSSSSSERGNMSVQQGKKPVVPGMSSGEDSSRPSTSYPQVPPAPLRPGWTLSRDSSVVRGINGDFHPGAQTPMSGMTHASWLTNNGNESNLSFTSSIMQEEAKLRWDSDEELKKMSKSMLRLQKWSLIIGLAGINGALIYIGWKYYQVYYFFLVLLSSNTVLQSFMCICIILHWFCTRVLCFWWRPKENIPAEPEKMVLLLPCYNETYEELTRSLDSLIAQKHIDNHPRVIFIVVDGNVRGPGMEKTTQEYLLQDILEPGPSRTFENGYRARDGLFMPVKTQTGFYKGIPYVFVGKRYNQGKRDSLCFARSLLYHFKQRSENVVTMFNNDLFEYIGNNFINAGLDDVTYLCGMDADTVFDEDCIYEMIVEIRKNPKVVGVCGHVCVDFDGSNWGYWSLYQSVEYSQTQGLRRMFQSRITGKVNCLPGCCQLIRVDEATFGDAVLRERFGYCPKPNDIMTQHIMGNYSEDSIHASIIFSLFPGCQTAQALRAKAMTIVPQDWKVFLSQRKRWALGSISNEFVMIFRPGIILIERLQSLIAVITWAITPFIIAAFVELLMVFAKRGKEVMSDPVFLGLICVLFFRYLYSFCIGFWLPRNNLERLQYFAGYVMHLFTSPFMNIIILVYSLFHSDDFKWGKTREVIRGEKDTDDAGGRGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SA95</accession>
    <name>A0A0E0SA95_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG09516.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T26899</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SA95"/>
    <dbReference type="FunCoup" id="A0A0E0SA95">
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    </dbReference>
    <dbReference type="STRING" id="229533.A0A0E0SA95"/>
    <dbReference type="EnsemblFungi" id="CEF83358">
        <property type="protein sequence ID" value="CEF83358"/>
        <property type="gene ID" value="FGRRES_17228"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26899"/>
    <dbReference type="eggNOG" id="KOG2157">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A0E0SA95"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="ATP-grasp fold, B domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
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        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
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    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
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        <property type="entry name" value="TTL"/>
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        <property type="entry name" value="TTL/TTLL_fam"/>
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        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
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            <begin position="3"/>
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    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF83358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="758" mass="84876" checksum="8B1D9225EEA66002" modified="2016-04-13" version="1">MHILVTNDDGPPSPHSSPYVHCLIQQLQQAGHTVSVCLPHTQRSWIGKAHMIGQTLKPLYYRPSSVVHGDESPGTTHHRPSPSGDVEEWVLVDGTPASCVQIGLHHFFQDKGPIDLVVSGPNYGRNTTAVFALSSGTLGAALEAAVCQKKSIALSFAFFTRNHDPVIIEAACRRSVKVIENLYKQWPTDGSADLYSVNVPLIEGLENNKAIWTNVLQNYWREGGCFQEIEGEAGDENEEEERIREGVGGEVDDAARPSSRKGHTHKHFKWAPKFTDVYKSVEESEPGNDGWAVKEGLTSITPLKANFMLGAGELFNQKEFELDSGSVANQSTQEMALRPKGPSIQAVISYEDAYVQPLILSALNSIFPEGVFNVITEVPESDEPALAKIVPSEENILQITAYESIDFEYAGSHERTTLINSYMIRKALIRKHFLSTTVDHWVAKHPESVLKTHIKRSEAFEVDFAEFLDDALVEAFDLRESMDRNEEQSDPSSKEWWILKPGMSDRGQGIKLFSSMDELQNIFDIWEEDQPDTDDEDEVADNDNDGDGITTSHLRHFVAQPYIHPPLLVDGEKRKFHIRTYVMCSGSLDVWVYKHMLALFAGKPYTAPADAPEDIESFLTNTCLQDSPNENTVRRFWDLPLSNDMRDDIFRQICDVTGEIFEAAAKAMPIHFQTMPNAFEVYGLDFMVDAQGTAWLLEVNAFPDFKQTGGDLKEIVSGFWKGVMRHGVAPFFGIESKIRDQEGAEDMVPVRKVDLGRR</sequence>
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    <accession>A0A0E0SE32</accession>
    <name>A0A0E0SE32_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
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    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T24171</name>
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    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SE32"/>
    <dbReference type="EnsemblFungi" id="CEF84695">
        <property type="protein sequence ID" value="CEF84695"/>
        <property type="gene ID" value="FGRRES_15416"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24171"/>
    <dbReference type="InParanoid" id="A0A0E0SE32"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF84695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="81" mass="8943" checksum="B0CD7FDA21AF6939" modified="2016-04-13" version="1">MSTKTIETPRTLSNVPKKEGVKCPDCDKDFARHSNLSDIKIPSTRDEITTAPTQITGTSSRADQMPKHISKESTNGKDRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0E0SHT5_GIBZE</name>
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            <fullName evidence="1">Chromosome 3, complete genome</fullName>
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        <name evidence="1" type="ORF">FGRAMPH1_01T17145</name>
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    <organism evidence="2">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF85998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SHT5"/>
    <dbReference type="EnsemblFungi" id="CEF85998">
        <property type="protein sequence ID" value="CEF85998"/>
        <property type="gene ID" value="FGRRES_15280"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17145"/>
    <dbReference type="InParanoid" id="A0A0E0SHT5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF85998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="87" mass="10010" checksum="7709C3A186B419ED" modified="2016-04-13" version="1">MEWPGLVWSVTSAKIWYSDDPMIWNSPARECQIISISEIDFHVGTEKGNDVRGNSCRTKTMYNISIFSIPTKFTSSRYGEKVNAFPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SPA8</accession>
    <name>A0A0E0SPA8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
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    <gene>
        <name evidence="4" type="primary">FG11090.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T21201</name>
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    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhzF family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SPA8"/>
    <dbReference type="STRING" id="229533.A0A0E0SPA8"/>
    <dbReference type="EnsemblFungi" id="CEF88271">
        <property type="protein sequence ID" value="CEF88271"/>
        <property type="gene ID" value="FGRRES_17480"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21201"/>
    <dbReference type="eggNOG" id="KOG3033">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0SPA8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF17">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00008270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF88271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="325" mass="35761" checksum="F3263C3197253FD6" modified="2016-04-13" version="1">MASSTVTTYKAFASERAIGNPAGVIILPNPSDDAGYDQDADFPYDIFPPASKLQEIATKLNYPMTAFAVPLSQSIDSPNAPHFAVRWLNPSNEAPLCGHATLALSQHLFSTLTNPPQTLKYLTRLHGIVSASLYQSPFQDAKLVGIEFPELLDLPALSQSDKRWGQLRKLFEQSTGSQWEGHSEPVGVFEADQYLLLEYSPELDLRGLVIDPTKLASLNKFIYIFQISTSVSEHIHTRVINAIGDHVAEDVATGSAHRAIIPHALSNAETTARLKQYHPDFSGNILKCLQQSREGGELTVEWLRDVKAVRIMGEAVLVGEDNIEI</sequence>
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<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
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    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T01127</name>
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    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YHQ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01127"/>
    <dbReference type="eggNOG" id="ENOG502QPV9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YHQ0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000203">
        <property type="entry name" value="PH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058155">
        <property type="entry name" value="Skg3/CAF120-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PH domain-like"/>
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    </dbReference>
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        <property type="entry name" value="PH_DOMAIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="130"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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    </feature>
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            <begin position="667"/>
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        <location>
            <begin position="735"/>
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    </feature>
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        <location>
            <begin position="756"/>
            <end position="765"/>
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        <location>
            <begin position="783"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="828"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        <location>
            <begin position="1369"/>
            <end position="1393"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB64058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1393" mass="150790" checksum="F890747B7DDB613F" modified="2016-11-02" version="1">MGRNRVLSFMSQFSAGTKTPPPSTSPPSDSPHKQGHHRRTVSGTEPFPDHRVSTDISRPNTPPSRPDYGTPLNGGSPIEPSTRRRRSSSAASSRPPSMVLAHQPPIMDITEDTIPELQPIYSFLNSHSNKLYQEGYFLKLDDQNTQGKPNPDRTWSECFAQLVGTVLSLWDASELDAAGEDGEVLPKFVNLTDASIKMIESLPTRSADEQPLQNILSISTAGRNRYLLHFNSRHSLLQWTAGIRLAIFEHSSLQEAYTGALIAGKGKSLNNIGVIMERAKFPTEEWVRVRFGAGVPWRRCWCVITPPDEKQYAKLQKELKKRSPYDRSPVPTLKGNIKFYDERKDGKKQKKAQPIATITDAYSAYAIYPQAKSLIEASTLLKVEGSISIHTDPPSSTEGFVFIMPETRPAVTGFEMLLRFLFPTWDTFGLYGRPGRLVASTLDSRSLMFAMPKSRRYGYLENLDVSNLILEDGSSNWGERDWRKKLKESTGTRMNAVDDAPATRSRSNSRKSVRLSFGDGPPTLKTNSDQQVPTRSSRSFSLGERARTDSAPADPARVALGSHGRNSSDPNQLGGPPFRPDANGNSPYSASPQRGQTPVGNQASRDQSPAYQNERGPNGSPPLKDLDGMRQMHTPEPVSRPPAFSHGSQGRPVSRAYHSPELRRANSRLSVTTLAQLSSAGGMGGPNDSRPSPGEDEVDAARSGPSVLPPHANSVGISANDNRSREVLSPTNQDPSSNNLPPPANLSQQRSRSPLGQPPLGPPSPYGRGPNSRPGTSVGRRSPMPPGMPPQQRPLHPQNGNRRPDMGPDGRRPSDTRRPGPDGRRPSDPRGPGFDGHRPSEPRGRGNGPPPGHGHPPPGPYGNYRPGPGHPPGPPGPPGSYGPPGSRPNGPPNGPPNGPPNGAQGQMAHRKPVPGHMPGPPPPGPAQFENTKGNTMSGSSAITTNEIIDHYAYDQGRQTPRQGTPNSERRPQLPGRLESNQSSQYDDHSPATSLRNFVDSYEYQEPKPRAGVLKTVGGAEETDKEFDIPDINFGPTINYGATKNRPHTPGGHGPTPPHKSSASQGSVGQKESPDSKRTMAWSPGGTAPPASTHGLSAEEFVQHRAAHARTASSNSIGGNLPGTPGPGIKRNSSSDILQAIQNGRHSRNTSADLLQRPGSRGANSTLNFASSGETSSHLSAREQEQMARLTGQPLLSMQGHQRQGSQGFSPGHQRQASSGSGLVGAIEAREREKQQMKQGMNSQAVQQAISQRQQQQAAMAYQQQMAQQQMAQQQMIQQQLAQQQQMAYQQQAQQQQQNYQQAYQQPMMGAGNMPAYSPMGQAPGQYTPGGSQYGPASQQMGGHGQPNSFSRPMRAAQQVDPRFVPPQGQYGSTPPGTQQASRSVHPQFQGQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YI22</accession>
    <name>A0A1C3YI22_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FGRAMPH1_01T00551</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YI22"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00551"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YI22"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="139"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="1172"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SCB64006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1485" mass="168292" checksum="36C28DC2A1D7CC35" modified="2016-11-02" version="1">MSPMTPIPSRQTTSHNELDTMDEHLTNLPMGVILKALNIFTAKFPELRILQASSFIKEYQTVRTKEGKALLATTLAITRKQCSIVTGDWLRGLRGSESYATYAWSTLSDAILQPPKVQVVQALLILTLYEWGVREYHKAWMHCGMAIRIMQSLHSSRITPHPLDVSQNSDTDAMAIAVESRTYWACFIMDCTINSGTYNPRMLPMSEMHKLKVPRPLNYTDFAFGFDATSLNYSAGDLSGLAQGFESIALGFDIYAQAMSFVFNNGRCAPGMCAAENCPWVPSSSWYQCRSRLEEWRKSQHKRLWYPQHSVVVHMTLGHGESFIYLNMLYYLTTIMLHREYFPFLPIGDMTPRGPVDPPLLEAEAPPGWWDQSARELFSASEQIACLLQEASECGIPLMTPFSGFCAFTACFLNLYVFRYPRMNLGRSTKAEQLMNWGLEYLEEFQNAWELAGGWIKTIQNSSLLYKRATEDEGRYRGRSRADFEALHQSIHEYRIVDRSDQHLQQISHADRNSSRREDGNDVPVPTQNQSMSAAVSASVSVPDPFPNWWSMLQEVEFTDVGNLWNGLREIALLDQRTIKLSTYGIIFMGTPHQGGNGVQLGRILVNAASVFVPADDGLLKHLERDSEWLLQQLGQYGPISGDFATKFAYEKYKTPIALGKKIMVMPRASAVVLGQADAEPIAIHANHKNMVKFTSKQDVGYITILETLQIMMKDTEVSIRARWEAERRVENARANATQFSLGFSLSEVNNVHHFVARDEELAQLQQILTTSHERRTVVIHALGGIGKTQLAIAFAKQNYKSFSAVFWMNATDKETLKQSFTRAADRILRERSPLAYLEGAIANDDTDEIVKDVGRWLSESGNNQWLVIFDNYNHPSFGDNVGRQHSQHDNSIISKDYDIRPFFPKTHQGAIIITTRSATVKLGKTMQLSKLRRIKDSLKISESTSNRLQLVKDPAAIHLTQELDGLPLALATAGAYLDQVAISCAEYLELYKDSWGRLQESSPQLLSYEDRAMYSTWNISFQNVEKQNKSSAMLLKLWAYFDRDDLWYGLLCSAEGLAPPWLDVLRDKLTFMESIRLLCDHGLVEVNTVIGENEAEYPGYSVHACVHAWMIDVLHTKTDTNMVQLAATCVASLIPNKDDHEYWRLQRRLLQHADRCSEIMADSTGIPDLVQWIYDSFGYLYMEQDRFEVAEVMFERALKQQDKTLGPEDISTLDTAHRLGLTYFHQSRLREAEAIYKRVLQRYEKLLGPDHAKTLDMVNNLGVVYLDQDRFREAEQMFERASKGYQVAFGYDNRFTLNVVTNMGSVYLCQGRLDEAEKICKRALRGWETTLGSNHISTLNAVNFLGKVYASQGRLGEAEILCERALQGLENALGLSHTLTLDTIHGLAHVYDIQGRVNKAETMYKRALGGREVSEPATGGANLLALKILEKLGNLYERTDKPELAEKVYLQVYDGYVAVFGDDSERARSVQNRLEDMALCQTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YI47</accession>
    <name>A0A1C3YI47_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T03779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YI47"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03779"/>
    <dbReference type="eggNOG" id="ENOG502SPY3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YI47"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="677" mass="75496" checksum="EDECCF9E5681454A" modified="2016-11-02" version="1">MLVHEPQVHCAANEAPVSSGCTTCRDLHNHEPNSTSYHSSSSPDRETLKELSSSQVQNQSLARRSPQQPQNQKLFLRSGPIRTPLPFRRTQHSSTDTEFENFEPLEVVEEEESMLSSTSLFTNSSHSAHRLLSEACTFKSHLLADTAPLSEKPYLPHRAGQFEWLVSFPMSPCEASDHGTLNKGENDHRNDETQVYGCTLLHRGPRYDAFGTRDKTDNYYFLATSLAAEEYLALGFEPSPIPCSTANMALAPPPAYQDDQAVPLKVPEVPEVVEQAVSPSLTLISDRSSSYGGSSRHGSFSVPRIEDSFEELDKLEDELEAIDAVTQARRIALPENATPSSKHLEPPSSARRPAISKRASVIGMSSTVRIKPTEKAQPPLRRSTSLVFRDKKQDDSDKTPKTKPSFARGKLANSPPVSKTPVKSAKPPTVPKFELPGEAVARRLREQREARKAQQAEAQKAYAPPPRPKSSKPLTKPAFELPGEAISRRKREEREARLKAQEEEEQRKREFKARPVRNSIMSTSIPRETIASLARQGKLPQEDTTKQPTSVKAKRMSSLGPRPAPEIQISQSRSRLSTATSHENLNKGTSASSGGSIGKRATLSAEEAHQLKMRGKEIFHRDNNGYVQDRERERREREAATRLAREQAAERSRIASREWAERKRLKELALLQSIRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YI59</accession>
    <name>A0A1C3YI59_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T03279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
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                <person name="Antoniw J."/>
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                <person name="Bluhm B.H."/>
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                <person name="Butchko R.A."/>
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                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
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                <person name="Kazan K."/>
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                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
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                <person name="Sakthikumar S."/>
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                <person name="Wapinski I."/>
                <person name="Yoder O."/>
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                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
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                <person name="Rep M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
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                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SCB64447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="271" mass="29822" checksum="062E20AB716A967D" modified="2016-11-02" version="1">MASGVEVAGSIVSLIDAALRIVNEARKARHRVLGIPTTLDNVSKQLNSIEESLTLVREERNLQSFAIEQQLQTIAQVAEELRQFYDRLSLVQQRSSTSKFVRSLRMGDREEKELEGILKRLDTAKGDLTVRILVAHVGVVGNFHDGFRVAYDVLAETNLNVQRVLGVNMALLELVENRDRKLDGTIPVVAAELEALEAPRFDASSEVVQNSIYSNKGVGFVMTGNVGVETNYQAAPRTNAITNNDFGKDGKVMTGDMGGAAAESFNQNFWK</sequence>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
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                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJ39"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05197"/>
    <dbReference type="eggNOG" id="ENOG502QQIR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJ39"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="804" mass="91819" checksum="14305560A4E047CE" modified="2016-11-02" version="1">MQLLRGDRGDTSSTSSRSYGGFGPSEPRLFEFNERGRSVAPKCIEMSKQHPEDFLNYLQQAWKRDKIYIKENPESMFDIKAIRVLCQDGKFRPLGNSYIPLPKLHYLRNRYMLEGEPFPFLRLDPPIRSEGGFGQWRCLRAFAKYHDDLDFFLEMLIRVRRSKATTVEFPRRILELYLRIQAECEDSKDPEASAHKVRYAFEKEQLVYIHPIWRPLSECLLDDSCEISSTLSKSPVFPVPEDWDASKSELASLREFYTQTLKLENASYRTILGVLEKRDFDAVLDPADLWLTDELYRALDKMRMDLSPNDAADLKLAFIEKPIIAVAPGETVTWLNATEVSWCPKLESPEVNDLSKHYPELHEFFIDFLDIKQNDAGLIFDTLMQVSSLSPDCSRDHTARGLLVAVSQRIPEYGHVFDKERFMQSNVFPVSTSDGVLLCAPSMEFVIADRQNLKEAFEGRLNLLDFDPKTVWMLDNLLVWAGLDQRYLSRHVVDQGPEDENFKSIELPDELSAKADHILRIAVHFKSPRTTTPKGTSWLRETLDHCEVRLASGFRSQLVYRSGSAEIIAVNPMGGLDIKDTVGLTVYADDENWEIFKQTLLPRRLLEWIMTDPETNVVQDIPEQAVSLMRSVVNVSNAREHVISRILDAEGIVDLELLQASPYWRVNSERQPDATISTSKADQFAASKIIDDSDSTPAPAYSQAGPSYSRDERPAYSKGEPSYTTRTERTYSNGEPPYSKEDPVKRRSPPPPPPAKPDSLRDRLPVSKRGLQRRVSEKQDWEGDFVANEATLVDFTGEDAYGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKN4</accession>
    <name>A0A1C3YKN4_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FGRAMPH1_01T20743</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="3"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKN4"/>
    <dbReference type="FunCoup" id="A0A1C3YKN4">
        <property type="interactions" value="1361"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YKN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20743"/>
    <dbReference type="eggNOG" id="KOG2862">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YKN4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000049">
        <property type="entry name" value="Alanine-glyoxylate aminotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000027">
        <property type="entry name" value="Serine--pyruvate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="9">
        <location>
            <begin position="62"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SCB64968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="385" mass="41117" checksum="D9FBDC7BCF747D7E" modified="2016-11-02" version="1">MSSQPEHATLLIPGPIEFDDDVLKSMGHYSESHVGPGFVNTFGETLSMTRKLFQSTDPSAQPYIISGSGTLGWDIVAANLVEAGEDALVLSTGYFGDGFADCLRAYGANVTKLDGEVGGRPQLPEIEKALSEKKYKILTVTHVDTSTGVLSELKNLAATVKRVSPETLVIVDGVCSVACEEIAFDEWGLDGVVTASQKAIGVPAGLSISFFSGRAVAAALENRKTPIPAYFASMKNWTPIMKNYEAKKPSYFATPSPQLVHALHTSLTQILSKPLSERFQGHIEVSNKVKKAITDLGLKIVATKPEDQAHAMTAIYLPEGVGAPDVLPKLAGKGVVFAGGIHKAIASKYIRFGHMGVSALDPSRNHMEKAINALKESLFEAGYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLN1</accession>
    <name>A0A1C3YLN1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FGRAMPH1_01T27125</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YLN1"/>
    <dbReference type="FunCoup" id="A0A1C3YLN1">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YLN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27125"/>
    <dbReference type="eggNOG" id="ENOG502QW2I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YLN1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000002">
        <property type="entry name" value="Initiation-specific alpha-1,6-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008687584" evidence="12">
        <location>
            <begin position="27"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="38"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="362"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="377"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SCB65447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="464" mass="52421" checksum="8403D5D9978D052F" modified="2016-11-02" version="1">MLNSRRAIVAAVFVLTVFFLLTRSHSSTPVVPAAQNAAAAADTSKNDAPASNEAVPPPPEKKEPEMEVKERRTRPRIDMSGMTTYEKLEYAYPYDVTSKFPAYIWQTWKQSPDQGDFQFKDHHGSWREEHPGFVHEVVTDDVAVNLIRLLYATVPEVVEAYRSLPMPVLKADFFRYLILFARGGIYSDIDTYAIQSSVKWLPEQISRDTIGLVIGIEADPDRPDWAQWYSRRIQFCQWTIQAKPGHPALRDIINRITKKTLDEKRKGTLETFVDRNVVEFTGPAVWTDAIIDYFNDGRFFDMSQSKGTIDYKNFTGMETSKRVGDVVVLPITSFSPGVGQMGSKEPDDPMAYVKHDFEGTWKPESERHMGEQKQEEGQQAPLQQEGQPQQGQPQQGQPQQGQPQQGQPQQGQPQQGQPQQGQPQQGQPQQGQPQQGQPQQGQPQQGQPQQGQPQQQQQPPPAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YM48</accession>
    <name>A0A1C3YM48_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein-sorting-associated protein 25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ESCRT-II complex subunit VPS25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T09863</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YM48"/>
    <dbReference type="FunCoup" id="A0A1C3YM48">
        <property type="interactions" value="830"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YM48"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09863"/>
    <dbReference type="eggNOG" id="KOG4068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YM48"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000141">
        <property type="entry name" value="vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.570:FF:000003">
        <property type="entry name" value="Vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SCB65596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="217" mass="24742" checksum="2B6C51B9CE364273" modified="2016-11-02" version="1">MLQSLEPLPRHRLQPPSLNTNLNITNHILTMAATTTTSAPADTFKFPREYHFPAFFTRQTNLTTLHAQHNKWADLILAYARHNRIFRLSLSEAADSDLFVNRKLDRRLQFDDIRDVVSFMHTDGRVEYVGGGTSGDVVFLYWRKPEEWAELVENYVEESGQKGSVLTVYELVEGDGTKGNDIHGMDTDVLLKALNVLVKRNKAQIFGQDDSLGVKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMT7</accession>
    <name>A0A1C3YMT7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FGRAMPH1_01T12157</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YMT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12157"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YMT7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="26"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SCB65753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="498" mass="55277" checksum="C60D0C5E79FED22E" modified="2016-11-02" version="1">MAENAGHIAVNDIVDLDQRIQDLVAVAPPFYKNKSLFRLYLLIIPTCLCAAITLGFDANFGHPRGALLGIMSAILPLGCVVATPFISLVGDRYGRRMGIFVGAVIMIIGAVIQGASVHFAMFLVSRFIIGFGLVFANAYAPMLIGELAHPKERQVITSLYQTSWYIGAILAAWVTFGTFSIPSEWSWRIPSLLQAAPAVLPISFVFCLPESPRWLIANGRSEEAKAMLVKWHANGNEDDELVKLEFIQMRNVIEAEVSNETGWKELFKSPGNRKRVFILVCLGCFSQWSGNGLVSYYLVRVLETVGVTDARERNILNGCLMIFNWLTSVASAFLTAYMKRRTQFLISVGGMFGIFAAQTLCAGLFNEDHNTAAGKAVIAMLFLFYFFYNLAFNALLYSYPVEILPYPIRAKGFSLLMFFGKASNFINTMVNPIGLQALAWKFYFVYVAWLAVELAIVWKFFIETKGPSLEAIAAVFDGHDASVLSEDSDLKKGESEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YN83</accession>
    <name>A0A1C3YN83_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FGRAMPH1_01T14479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YN83"/>
    <dbReference type="FunCoup" id="A0A1C3YN83">
        <property type="interactions" value="558"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YN83"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14479"/>
    <dbReference type="eggNOG" id="KOG3332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YN83"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008687678" description="N-acetylglucosaminylphosphatidylinositol deacetylase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SCB65903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="285" mass="31770" checksum="EDC7114859BA44A9" modified="2016-11-02" version="1">MNVLHIFAGLAVVVPSIYMLTANQAQSTIKNKRVCLLIAHPDDEAMFFSPTVLALTRPENGNHVKILCLSTGDADGLGDVRKQELVKSGLALGLQNEDDVFVVDNPTDFPDSMNRMWDKNLIARLLGSTFAPKFGHERKNNLKPTAAIDILVTFDSNGVSSHPNHISLYLGARSFIQALTTTESEWPSPVDLYTLKSVGIVRKYSAFMDFVPTLLSHLGVNNENKDRPEGLVFMNQLVGRGAYGTAWSAMTQAHRSQMVWFRYGWITLSRYMVINDLRLEKVKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I1R9Z2</accession>
    <accession>A0A098D000</accession>
    <name>I1R9Z2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG00309.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T00819</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315957.1">
        <property type="nucleotide sequence ID" value="XM_011317655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1R9Z2"/>
    <dbReference type="FunCoup" id="I1R9Z2">
        <property type="interactions" value="624"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1R9Z2"/>
    <dbReference type="EnsemblFungi" id="CEF72213">
        <property type="protein sequence ID" value="CEF72213"/>
        <property type="gene ID" value="FGRRES_00309"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00309"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00819"/>
    <dbReference type="eggNOG" id="KOG2343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011757_0_0_1"/>
    <dbReference type="InParanoid" id="I1R9Z2"/>
    <dbReference type="OrthoDB" id="269405at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="4">
        <location>
            <begin position="54"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="5">
        <location>
            <begin position="336"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF72213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="757" mass="86504" checksum="C52AA581A6370039" modified="2012-06-13" version="1">MDGSAAIPDDDIARLSLNYQYEPPPPPPPDIMTAGIVAVDITDKFTQAVNTLAPGDLVKDDSFTLFDSVAALEIMDPKMDSGCVKSPDELEELYDVSRPLLPEEVLGIIDQLLCHEMAWHQGYPLSQTLFTSIYAEALLTPTPQTVKDARFVRNATSESSGSSNMLEILRAYCLGLLKACGYVNERIRSEHYYEEEDFVTNTYHRTLLAEIQPEHIQHAIQEARSLLITLGDEISHELRQALDQRLQLRSYFLKATECPKYMREPDVARKPWLDCLNLLPGIKASHDLGQPVDDAFSAKLQRKLASTMPPRPIVQLKFEDAFGHLTRLFSDGAELIDVLNYTDSQCLQNFVYYFQAKKPQPLVFVRTLLQTFLFNEMEVLGSMSIRQILDDDFSIVTLPASFQLDRNNDEIEVPQDPRFIVAEQMELFRKRAAQPFLDIFRTYCQNRCRVRRTLCHVIRDWENLQVDAEELDQRIQVRLSEEPMRRLTGTNSAPVETWSLPLSSWTYLYKIHQMETIVQLGFELEVYQPDELAGMYWYLNYLAKWRLQHAERIKSFIVRKVEESRASPNPHDPTVDRQLERSLAFTRLTLLDAAVTWELSDALSCVYTILLRLKLIKLPPRPYSNDELRFDLRMRPFAVIGLPPLPNFQEFTEGTAQPESPTADILNYAERALKGAKRGLEALSKLSARDAFSVGSHDKWVTSKKNALKACIATGLAITTLQKALERGADDLKIKAEVPTPDKCYHDWWIVPRVVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1RAC9</accession>
    <name>I1RAC9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG00456.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T01177</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316125.1">
        <property type="nucleotide sequence ID" value="XM_011317823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RAC9"/>
    <dbReference type="STRING" id="229533.I1RAC9"/>
    <dbReference type="EnsemblFungi" id="CEF72390">
        <property type="protein sequence ID" value="CEF72390"/>
        <property type="gene ID" value="FGRRES_00456"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00456"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01177"/>
    <dbReference type="eggNOG" id="ENOG502S92A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087661_0_0_1"/>
    <dbReference type="InParanoid" id="I1RAC9"/>
    <dbReference type="OrthoDB" id="5426165at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40623">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40623:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF72390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="184" mass="20687" checksum="E4B460CCA9888770" modified="2012-06-13" version="1">MGAFFISWELWQEMTFVLGCCIVLVFVAGLIKLWWSNRAMRRHEIIDEEKRARLSLMSYCGIQNMRTPDIPFGIRAIQSGIEVEGIWISRPESPESCQATPSATLVGRRIRISKGKGKMIDLVSSECLPSTNLETMPPRQVGLGGSQQDDITPINEYNRPGPPAKQSRITASKDQSLDLTYTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1RAD6</accession>
    <name>I1RAD6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG00463.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T01191</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316132.1">
        <property type="nucleotide sequence ID" value="XM_011317830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RAD6"/>
    <dbReference type="EnsemblFungi" id="CEF72397">
        <property type="protein sequence ID" value="CEF72397"/>
        <property type="gene ID" value="FGRRES_00463"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00463"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01191"/>
    <dbReference type="eggNOG" id="ENOG502SM8K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036638_1_0_1"/>
    <dbReference type="InParanoid" id="I1RAD6"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124016" evidence="2">
        <location>
            <begin position="17"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF72397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="403" mass="44892" checksum="A6AF91C51BA3FA19" modified="2012-06-13" version="1">MSLPVALQSVVFYVLACTPCAQVRHRQKAREQHKREREEKAKVMGEQPAAYQHPSPFNTNPYWQEEISMGPTLPKKTASKNSSQRGFAREGAGSSAFSVSEQTNNGGSRMNFGASNSVIAEDDNLSDDWNRRHGYQREDEELWGQWGGQRFKDAISKARDSAGRLIESTLGLEKEVTEQQRHDFYFPKNPPVNEYHPPVVSSKAPSRNAHQWMLQPPPSAKVMEGKVPVSRAASSGSKSSGRTLVGDDTQLSRLVHEKLVMEKLRKEYGNPTETELIESLFLNRTNQSLSIHRTRSLSFDTSDDSLDSGFAKRKTRLRPVAAPPGYDSSDDDSDSDVPAPFTHSSPRRKHSAAQRPKLETIQSTRSATATRMSSKRSKGSKRQRSTRSKRFSGAASPVGDDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>I1RAP1</accession>
    <name>I1RAP1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG00573.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T01459</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316258.1">
        <property type="nucleotide sequence ID" value="XM_011317956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RAP1"/>
    <dbReference type="STRING" id="229533.I1RAP1"/>
    <dbReference type="EnsemblFungi" id="CEF72530">
        <property type="protein sequence ID" value="CEF72530"/>
        <property type="gene ID" value="FGRRES_00573"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00573"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01459"/>
    <dbReference type="eggNOG" id="ENOG502RSRA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019529_0_0_1"/>
    <dbReference type="InParanoid" id="I1RAP1"/>
    <dbReference type="OrthoDB" id="5319458at2759"/>
    <dbReference type="PHI-base" id="PHI:1988"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G12570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="606"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="617"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF72530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="665" mass="75095" checksum="3BCD08BBDA948618" modified="2012-06-13" version="1">MPRPSFSHNPLLRVSRPVSACSRCRAAKVKCDGKLPACTACEKAGRTNECSAANDQFARGKERSYVAALELRIEKLEKRLQFAKSRKASVALHDTDASAFNVQQMDRRDSLALIRAAIHRKAAHKRETLDVNSLVSDFGFLSVNATTRDFEPISTNMTFARLVLAATINDALPEAPEACLPPRPTAHALVQHYMDNIYSLFPCISETALLTALDDMYDKNNSRHIQHSEYWMVYMVLAIGSISQSRRSNDTHYQDGLKYAARAVNHADEALAPGYVTQIQSLLLLTQYAMLDPAHFDSWHSIGFTARAIVDLGFHQDPPLSSVSDKSALDMRRKIFYCVYALDRTISMVYARTFSFTDDTVNVAFPQASGNAGRGSASGALSGPQSADPALLLFQLRRAQSHWYQDLYQSGSVPLQDPISYVWRMCLDMREWQDTLPNNLAPEIRQLFDQELRYSYVYCIAPSTRAPNITDYNRILIFEHSMAYLDTAYDIAQSGQNWGFFTYHDVMRIFFMASQFLAVLRDAEDMLLSGMPVPIPIARPGTAPAPPLPRRLQPQGMNGEDNLDRSLRCLDKVSQTLNIFGERWVDASHLRENFGLISQEVVERLSERRQRRDTAREQYQSQYQSRGMPPQSQGGYQVQNSHQQEEMQWAGVDVAHMMRGGYPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I1RBM5</accession>
    <name>I1RBM5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T02403</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316697.1">
        <property type="nucleotide sequence ID" value="XM_011318395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RBM5"/>
    <dbReference type="STRING" id="229533.I1RBM5"/>
    <dbReference type="EnsemblFungi" id="CEF73004">
        <property type="protein sequence ID" value="CEF73004"/>
        <property type="gene ID" value="FGRRES_00955"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00955"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02403"/>
    <dbReference type="eggNOG" id="ENOG502QWSS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022136_0_0_1"/>
    <dbReference type="InParanoid" id="I1RBM5"/>
    <dbReference type="OrthoDB" id="5308060at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013952">
        <property type="entry name" value="DUF1776_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF1">
        <property type="entry name" value="3BETA-HYDROXYSTEROID DEHYDROGENASE DHS-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08643">
        <property type="entry name" value="DUF1776"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF73004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="496" mass="54294" checksum="8A52E63A16FBF95A" modified="2012-06-13" version="1">MSIDPQQLLDQLSTQARRYSDIAAEFIDKNVDRAAVVVRETLSTSEWVPESVRPSPPVKEVVAVVSLSRFERLQTWIAEHKILTGVIVLTCGTVVYKGYYEGRSMRKTRRARRARNGGRTDVVVIAGSPTLPLTRSLSLDMERRGFIVFIVCNAAEDESMVQAMKRADIRPLSIDTTDPPHAGSAIERFAHFLQSPQAPGPGMKSNQLTLKSVILIPSLHYQTSPIATIPPSNFADLFNTHLLQPILTIQAFLPLLTSRLNPIGEKWIPPKVLVFTPSIISSINPPFHAPEATVCSALSAFTEVLTAELRPLDIPVTHMQLGTFDFSSFVPTRGGPNQGLVMPAGNPESPLVWPEGARHVYARNFVAQTSSAISGGRIRGLKGSSLRRLHNSVFDVIDGDIVADTVRVGLGASVYGFVGRWAPRSLVSWMMGIRRVDELSTWKTSAFEGSESSDDEDDESEKGEDGTSSEFIAVSDDNVWHADTGAVWSHKAPEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1RDQ7</accession>
    <accession>A0A098D4T2</accession>
    <name>I1RDQ7_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG01771.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T04305</name>
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    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317610.1">
        <property type="nucleotide sequence ID" value="XM_011319308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RDQ7"/>
    <dbReference type="EnsemblFungi" id="CEF73959">
        <property type="protein sequence ID" value="CEF73959"/>
        <property type="gene ID" value="FGRRES_01771"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_01771"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04305"/>
    <dbReference type="eggNOG" id="ENOG502SRM6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093550_0_0_1"/>
    <dbReference type="InParanoid" id="I1RDQ7"/>
    <dbReference type="OrthoDB" id="4160690at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124105" evidence="2">
        <location>
            <begin position="19"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF73959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="202" mass="21364" checksum="2D0852325933BB8E" modified="2012-06-13" version="1">MRSFVAYTLLASATLAVAVDPRFEYPDTVPLVKRQQPGTPQYACHEDCGLLITLARENKDFCDSQEWNDHYDQCMECAETYGIWKYYGSGVSKVAGQCDLSPTPSPSGAATKETATSSSDGSGTTAPGKITTEAPTEVPSTTIAIESTVIATPSAMTTTDVSSGNTATSTPEPSSVAVNGAAKHFEFTTAIVFAAFAIFNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RF10</accession>
    <name>I1RF10_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG02272.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T05483</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318178.1">
        <property type="nucleotide sequence ID" value="XM_011319876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RF10"/>
    <dbReference type="EnsemblFungi" id="CEF74546">
        <property type="protein sequence ID" value="CEF74546"/>
        <property type="gene ID" value="FGRRES_02272"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02272"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05483"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_2_3_1"/>
    <dbReference type="InParanoid" id="I1RF10"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF22">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF74546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="553" mass="60315" checksum="1D15314AC7811E8D" modified="2012-06-13" version="1">MTNDVETNSALKRQPSTPQAIRDAEDLANFGHDQSLTRKFNMWSMLALAFSVLGTWSTFAQGIDSGLTAGGPIAILWGLVLVFACNICVAVSLGEMCSSMPTAMGQAYWISRLWPTPAGRFTSYLCAWINMTGWITLSASQIAFMSEFLLKMKILFTPDWTGADKGWVLFLVYVGVTGVMTLFNVVACRKDVVLPWFNNFVGISFASLFVIISMAMLISVGVKEDLHFQSAGFVFGKWINQTGWPDGVTWFIGLVQAAYGLTAFDAAIHLVEEIPSPRTNIPKIIWLSITMGAITGFIFMVVCLFCMVNSDIYLNPTTGLAFMDLLKDTVGLQGGTVLLTLFIINGFGQGIGIVTTSSRLTWGFARDGGLPFSGYFARVDDFWKVPVRALWLQGGIMALIGILYTFASTVLEAILSVSTIALTVSYGMPILTLLLVGRDKLPPGEFSLGRFGSVINWVGVVYCAVTTVFFFFPSAPNPAVADMNYAIAVFGIMLVVTLVFWVIKGRVTYLETEEAQGNIIYAQRAERANYVDIVGKSDTAAPQPQRVGEASGH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RGC4</accession>
    <name>ERG6A_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol 24-C-methyltransferase ERG6A</fullName>
            <shortName evidence="6">SCMT</shortName>
            <shortName evidence="6">SMT</shortName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Delta(24)-sterol C-methyltransferase ERG6A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Ergosterol biosynthesis protein 6A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">FG02783.1</name>
        <name type="ORF">FGRAMPH1_01T11303</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Mol. Plant Pathol." volume="14" first="71" last="83">
            <title>Involvement of FgERG4 in ergosterol biosynthesis, vegetative differentiation and virulence in Fusarium graminearum.</title>
            <authorList>
                <person name="Liu X."/>
                <person name="Jiang J."/>
                <person name="Yin Y."/>
                <person name="Ma Z."/>
            </authorList>
            <dbReference type="PubMed" id="22947191"/>
            <dbReference type="DOI" id="10.1111/j.1364-3703.2012.00829.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="1228" last="1228">
            <title>A phosphorylated transcription factor regulates sterol biosynthesis in Fusarium graminearum.</title>
            <authorList>
                <person name="Liu Z."/>
                <person name="Jian Y."/>
                <person name="Chen Y."/>
                <person name="Kistler H.C."/>
                <person name="He P."/>
                <person name="Ma Z."/>
                <person name="Yin Y."/>
            </authorList>
            <dbReference type="PubMed" id="30874562"/>
            <dbReference type="DOI" id="10.1038/s41467-019-09145-6"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2013" name="New Phytol." volume="198" first="821" last="835">
            <title>Characterization of the sterol 14alpha-demethylases of Fusarium graminearum identifies a novel genus-specific CYP51 function.</title>
            <authorList>
                <person name="Fan J."/>
                <person name="Urban M."/>
                <person name="Parker J.E."/>
                <person name="Brewer H.C."/>
                <person name="Kelly S.L."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Fraaije B.A."/>
                <person name="Liu X."/>
                <person name="Cools H.J."/>
            </authorList>
            <dbReference type="PubMed" id="23442154"/>
            <dbReference type="DOI" id="10.1111/nph.12193"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="1 7">Sterol 24-C-methyltransferase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (By similarity). ERG6A and ERG6B methylate lanosterol at C-24 to produce eburicol (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methylfecosterol. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum. The C-8 sterol isomerase ERG2 then catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturases ERG3A and ERG3BB then catalyze the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturases ERG5A and ERG5B further convert 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>lanosterol + S-adenosyl-L-methionine = eburicol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52652"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:70315"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:52653"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="induction">
        <text evidence="2 4">Expression is increased in the absence of the C-24(28) sterol reductase ERG4 (PubMed:22947191). Expression is positively regulated by the FgSR transcription factor that targets gene promoters containing 2 conserved CGAA repeat sequences (PubMed:30874562).</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323031.1">
        <property type="nucleotide sequence ID" value="XM_011324729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RGC4"/>
    <dbReference type="SMR" id="I1RGC4"/>
    <dbReference type="FunCoup" id="I1RGC4">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RGC4"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T11303">
        <property type="protein sequence ID" value="FGRAMPH1_01T11303-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G11303"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02783"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11303"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039068_5_3_1"/>
    <dbReference type="InParanoid" id="I1RGC4"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="UniPathway" id="UPA00768"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000121">
        <property type="entry name" value="Sterol 24-C-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0752">Steroid biosynthesis</keyword>
    <keyword id="KW-0753">Steroid metabolism</keyword>
    <keyword id="KW-0756">Sterol biosynthesis</keyword>
    <keyword id="KW-1207">Sterol metabolism</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000454367" description="Sterol 24-C-methyltransferase ERG6A">
        <location>
            <begin position="1"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q4W9V1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="22947191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="23442154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="30874562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="22947191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="23442154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77454"/>
        </source>
    </evidence>
    <sequence length="381" mass="42479" checksum="E6A99865294EED44" modified="2012-06-13" version="1">MVASSNTGLEREDHQRDADFNKAMHGSSAQARGGVAAMFRKGGAAKQAAVDEYFKHWDNKPAENETPEERAARQAEYATLTRHYYNLATDLYEYGWGQSFHFCRFSQGEPFYQAIARHEHYLAHQIGIKDGMKVLDVGCGVGGPAREIAKFTGAHITGLNNNNYQIERATHYAFKEGLSNQLEFVKGDFMQMSFPDNSFDAVYAIEATVHAPTLKGIYSEIFRVLKPGGVFGVYEWLMTDEYDNDNLRHREIRLGIEQGDGISNMCKVSEGIAAIHDSGFEMLHHEDLADRPDALPWYWPLAGELRYVQTVGDFFTIVRMTTWGRTIAHGLAGLLETFKLAPAGTKKTADSLALAADCLVAGGRDKLFTPMYLMVARKPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1RGV6</accession>
    <accession>A0A098DGW4</accession>
    <name>I1RGV6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG02986.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T11785</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322805.1">
        <property type="nucleotide sequence ID" value="XM_011324503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RGV6"/>
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    <dbReference type="EnsemblFungi" id="CEF77695">
        <property type="protein sequence ID" value="CEF77695"/>
        <property type="gene ID" value="FGRRES_02986"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_02986"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11785"/>
    <dbReference type="eggNOG" id="ENOG502SHFU">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_479824_0_0_1"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Reticulon"/>
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    <dbReference type="Pfam" id="PF02453">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
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    <feature type="domain" description="Reticulon" evidence="8">
        <location>
            <begin position="91"/>
            <end position="231"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="312"/>
            <end position="548"/>
        </location>
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            <begin position="314"/>
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        </location>
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        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02453"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF77695.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF77695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="548" mass="59109" checksum="1A3874A3B436EE00" modified="2012-06-13" version="1">MTQLMSRQEPENHHERIDQHVMTHWKFSPKLSSSTTPDKGLTQLADMSGIQNNFQPVVAEDTTGPQINGQRRRSGPLKDIVAQQDSLYKYISWEDPARTIGSYFAALGFLLAVHHLRLTQLALKTSAIGLGVMSVAEFAGRSFGPNNFVSRMRPKQYKTFPESTLNATLKDIHDLIQYAAVKAQKVMFAEDLEKTFSAFLIATSLYFLTQFMTPFGITILALTTVYIIPLVRSPQGRGIARDGIARAQEIGNVAVDQASTMAQDSKAAVSNMASRAQDTASNLTSSAQDTAGTLRQRAVNMVPVNMVPGVMKGNTASDITSSVPHSSSDPTQARDVSSKYPKDDMSFNDSKEMASKVAHDMSHSFEKSPKSSFNTSDKSYSSSDKPNYNTTSGKPSFSSFDTSAHAPGVSQSAVQGFPEPSKDSFPSHGPSDDFGAVTSNKSQAPSSLTSNISNIPSFTATESNLSSNQAPAGKRPSIDDGDYSIQNKMDQGSDYQRFVPREAPNRGNLGIGADTSMGKMPLGDLIDQKNEAGDKAPPLSGGGINAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1RGY4</accession>
    <accession>A0A098DGZ7</accession>
    <name>I1RGY4_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG03016.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T11855</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322772.1">
        <property type="nucleotide sequence ID" value="XM_011324470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RGY4"/>
    <dbReference type="STRING" id="229533.I1RGY4"/>
    <dbReference type="ESTHER" id="gibze-q4iie2">
        <property type="family name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF77730">
        <property type="protein sequence ID" value="CEF77730"/>
        <property type="gene ID" value="FGRRES_03016"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_03016"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11855"/>
    <dbReference type="eggNOG" id="ENOG502SJ7S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_3_1"/>
    <dbReference type="InParanoid" id="I1RGY4"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43689:SF8">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43689">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="38"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="309" mass="34924" checksum="0F51E56D105A774A" modified="2012-06-13" version="1">MTSLQDPSVLTQTFHYETSTHVYDVKWVTLGDEGLPPLVFIHGTPWSSRVWTDFAIALSRRFCVYLFDRPGFGESPPELLKQGLLPSIHPVEQFDSNLARQAEVFAALYQEWEASWSYPTAHVVAHDNGGLVSLRGYLLHELSYESLCLIDVVAIGPFGQPLFKSMAENPHIFEQLPDTVFEGILESYIRDAAFHELPSETMQMLKEPWTREGGKQGFIRELCQANWRSTEEVEGRYGEAGSKLRVKVIWGAEDKWLPVEMAYRLGNALKAVEIVVIDKAGHLSMIDQSAQMGIELAIWLNEASHEQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RJS3</accession>
    <name>I1RJS3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG04105.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T14501</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321531.1">
        <property type="nucleotide sequence ID" value="XM_011323229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RJS3"/>
    <dbReference type="STRING" id="229533.I1RJS3"/>
    <dbReference type="EnsemblFungi" id="CEF79054">
        <property type="protein sequence ID" value="CEF79054"/>
        <property type="gene ID" value="FGRRES_04105"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04105"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14501"/>
    <dbReference type="eggNOG" id="KOG3171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053880_1_0_1"/>
    <dbReference type="InParanoid" id="I1RJS3"/>
    <dbReference type="OrthoDB" id="70588at2759"/>
    <dbReference type="PHI-base" id="PHI:1162"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02987">
        <property type="entry name" value="Phd_like_Phd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001200">
        <property type="entry name" value="Phosducin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="81"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF79054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="289" mass="32644" checksum="0DF4FE0E07DE1E45" modified="2012-06-13" version="1">MSTAAQEEFNDLVAKNTHRETLHPEDRDDPDFKDIQDLSEEDLFRNAQIDNAMRMPTVDRLTGAGASEIKLPPVSFDNGRATGVKGVIADARNYEAARKNKWRHRVRTARNSIFGIESAPPAKSDTESSEDDAKSDADEEAFLAEWRESRRRELESEASRSVRNNRRTSPSVRIYGRLDEVDALGYLDAIEKVSRETTVVVFVYDHECEVSATIEQALMPIVKANPEVHFVKVHYEEIEFDNAAVPAILGYRNQGDLFANLTGLIEMIPDDETFGTSSLRELFQKHTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I1RK73</accession>
    <name>I1RK73_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG04266.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T14875</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321354.1">
        <property type="nucleotide sequence ID" value="XM_011323052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RK73"/>
    <dbReference type="FunCoup" id="I1RK73">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RK73"/>
    <dbReference type="EnsemblFungi" id="CEF79239">
        <property type="protein sequence ID" value="CEF79239"/>
        <property type="gene ID" value="FGRRES_04266"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04266"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14875"/>
    <dbReference type="eggNOG" id="KOG1938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014185_0_0_1"/>
    <dbReference type="InParanoid" id="I1RK73"/>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF79239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="757" mass="84330" checksum="6C503DCDE99F38C3" modified="2012-06-13" version="1">MPQPLENEATPTEPLQALPAAASGMKFTKSRHSTPVLASLPLSQSETNLAYRRSNPSAASLYASTLSPPGSRSISPAGRGSPARVLSHTVFDARPNRLPETGGDASEPLNLMLRAFVPHVSIYTSEDTDSLMGEKGFRGGLWELLRPFGEDVQGKITIRDSNGMSRVADGFSIRFTRLGDNIEHPDPTVSGFRSPASAHGQNGSQASTSRDKQFLADVESVVDRHLSYAEQSFAVLPHYGMFADQNAASGETSPYYALYLRRLLSGLPISPHETFSHPVACVIAVSSRNPDPITEMRKLYTETNEGSKRLPPWVDSEFIRYYVLVHDEERDDIIQSMAVFEQMKRHLGIHCHLLRLRSSQSAETDDDSIPLPRSDWMSAHEELEDIRHSEDDEDFEDPTRHIFESDATAIRTFVREMVTMSIIPQMERNVSIWNDQVASRRRGITGRFMNLSRKWAFGGSSRNSTGGTSNSRDNYNAAGFYGSEAPEAIMRKLADYSFMLRDWKLAHSTYDLLRSDFSDSKAWKHHAAANEMAAFSLLIFPQQMSSKNRAETIDQMLEAAFYSYNTRCSAPYGALRSLLLGFELLRLRNGTNIDDAGRWGVRLLESKISGNVGDALIKERLAVCYSSKEGVGSWHWGSRRRKSATWSILSADAWLQQSRHIQARRCLDEAHRTYSTLPHKEGITKFGAAGHFMASLQHSLAESPDASDNDSEDGGDDDIDEESEALNDMRPRRASTVTADMFRDTTKEEGSTTDDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RKC9</accession>
    <name>I1RKC9_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG04329.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T15019</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxin-14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321285.1">
        <property type="nucleotide sequence ID" value="XM_011322983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RKC9"/>
    <dbReference type="EnsemblFungi" id="CEF79311">
        <property type="protein sequence ID" value="CEF79311"/>
        <property type="gene ID" value="FGRRES_04329"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04329"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15019"/>
    <dbReference type="eggNOG" id="ENOG502S3Q3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044743_0_0_1"/>
    <dbReference type="InParanoid" id="I1RKC9"/>
    <dbReference type="OrthoDB" id="441517at2759"/>
    <dbReference type="PHI-base" id="PHI:8213"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0811">Translocation</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="9">
        <location>
            <begin position="66"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF79311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="379" mass="41504" checksum="1597C670E76215E0" modified="2012-06-13" version="1">MGDSDSNPTIPSWQKAQSDETDSQTTEPVSTPSTSASTSEVDAPAAGATAEETAQPENTPDDQPDDQEKLEVARRFLESDAVRDAPYEKKVEFLKSKGIDEAEIQALLGPDDTTTQNESSTSSEATSSNAPTPTETLPPSPASQPTPDRPPIVTYPEFLAKSPRPPPLVTKERLFNALYAVTGLSTLVYGTSRYVIRPMVDSQAEARTEFHDLTSKKLDALVAKLEKTVSEVPPKKPIATAEEESDAEDPTEMFHRDMGTQTTFPISSVTALKGSAGRESPARHNTNQIASLNKTLSGLKDEYRFQSEGMDKIKSAVDVLRDDLDTLTYTSYPEQSNGYDLYGRSRKPEPDDEIRKVRDSIRRVKGVLLSTRNFPTSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1RKQ3</accession>
    <accession>A0A098DKJ2</accession>
    <name>I1RKQ3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG04468.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T15375</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321129.1">
        <property type="nucleotide sequence ID" value="XM_011322827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RKQ3"/>
    <dbReference type="EnsemblFungi" id="CEF79489">
        <property type="protein sequence ID" value="CEF79489"/>
        <property type="gene ID" value="FGRRES_04468"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04468"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15375"/>
    <dbReference type="eggNOG" id="ENOG502SK2W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027816_3_0_1"/>
    <dbReference type="InParanoid" id="I1RKQ3"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="66"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF79489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="488" mass="52970" checksum="AE626352D55DE78D" modified="2012-06-13" version="1">MSSYPQDAHNDIYPSDQGNDSSKTNSKEKMPLDNEKGHIDDLQSAHNVPVVENGFGGGEGAKNFRNMTKWDTTFALLTNQVGLGVLSLPSVLKTMGIIPGLIAIIGIGLLSWYTAYVLKQFFGRHQHVMNVVDMTKVVGGRPLSIISGLGLLVQVIMTAASASVTLSIAFNTISSHSLCTVGYIGIACLCCWVLCAPRTSKFVSQSGIPCMVSVIAASILVMVSLGVKNPTAAPADWHKEIKVVANPDFRSGLNACLKICYAYSGNINFVTYMAEMIDPVKDFGFALAWLECVSIAFYVIVAIAIYCLAGEYTVSPALGSAPELIAKIAYGIVLPAIFSTGLAFGHTGIKYVYVQVMKHFKLQSEMTTNNVRSWSIWMTIVTVFWVLCFILSNAIPVFDSILSIASATTISWFTFGFSGIFWFHMNWNQLFSSPKNIMLFCLNSFLIGISLFMNAAGLWSSITELLDLFANSSSSIQGVFSCGSNSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1RL34</accession>
    <accession>A0A098DL24</accession>
    <name>I1RL34_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG04614.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T15707</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320963.1">
        <property type="nucleotide sequence ID" value="XM_011322661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RL34"/>
    <dbReference type="EnsemblFungi" id="CEF79653">
        <property type="protein sequence ID" value="CEF79653"/>
        <property type="gene ID" value="FGRRES_04614"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04614"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15707"/>
    <dbReference type="eggNOG" id="ENOG502RKS3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091066_0_0_1"/>
    <dbReference type="InParanoid" id="I1RL34"/>
    <dbReference type="OrthoDB" id="5428787at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124369" evidence="1">
        <location>
            <begin position="22"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF79653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="208" mass="22391" checksum="502234042577EFC6" modified="2012-06-13" version="1">MVAVKSISLLFALVTESLVASQNLIFTRKVNVVVIPRPTTTTFTDVKTITETTQADPDVETAIETKADVTTTIEVRLHTTTSISTSSRTITAYTTTSTIQAPAGSTPAKGSDWRPKIKARDSLNTLKERAAVELFPAGLQSNPEYVQRVDCTKKVPSTSIKVTTITVKGTRVTASPKTKTKVITSSTTTELHVKLGPTVVTVCRVALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I1RM12</accession>
    <name>I1RM12_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG04986.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T16809</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323464.1">
        <property type="nucleotide sequence ID" value="XM_011325162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RM12"/>
    <dbReference type="FunCoup" id="I1RM12">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RM12"/>
    <dbReference type="EnsemblFungi" id="CEF88849">
        <property type="protein sequence ID" value="CEF88849"/>
        <property type="gene ID" value="FGRRES_04986"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_04986"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16809"/>
    <dbReference type="eggNOG" id="KOG4549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071162_0_0_1"/>
    <dbReference type="InParanoid" id="I1RM12"/>
    <dbReference type="OrthoDB" id="2865258at2759"/>
    <dbReference type="PHI-base" id="PHI:5725"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Putative magnesium dependent phosphatase"/>
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        <property type="entry name" value="HAD superfamily/HAD-like"/>
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        <property type="entry name" value="HAD-like_sf"/>
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        <property type="entry name" value="HAD_sf"/>
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        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
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        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1"/>
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    </dbReference>
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        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C1.5.2:_MDP_Like"/>
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        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
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    </dbReference>
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        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF88849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="225" mass="25104" checksum="41528A97DCC7FC25" modified="2012-06-13" version="1">MPRKLSKNPLPPSSSTLSSMSSASGASSLLPSSLADPSLPLPKLIVFDLDYTLWPFWIDTHVTPPLKPNSSHTSATDRYGEDYGFFSDVPAILYALPRAGIKIGVASRTSAPSLARDLLKMLHITAPEGNTKEKPKKALDMFDGLLEIYPGCKIKHFESLQKRTGIKYEDMLFFDDEARNRDTESLGVTMCLVKDGVTWDELERGVTQWRNKRGYIKRPDAIELE</sequence>
</entry>
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    <accession>I1RM40</accession>
    <accession>A0A098E2Z1</accession>
    <name>I1RM40_GIBZE</name>
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        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
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        <name evidence="1" type="ORF">FGRAMPH1_01T16895</name>
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    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323501.1">
        <property type="nucleotide sequence ID" value="XM_011325199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RM40"/>
    <dbReference type="EnsemblFungi" id="CEF88471">
        <property type="protein sequence ID" value="CEF88471"/>
        <property type="gene ID" value="FGRRES_05019"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05019"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16895"/>
    <dbReference type="HOGENOM" id="CLU_1619182_0_0_1"/>
    <dbReference type="InParanoid" id="I1RM40"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF88471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="164" mass="19226" checksum="F464ADB1A05CEB3B" modified="2012-06-13" version="1">MCIKQQFNENVDNGDNGENDERTKENKCPICQKQPRFARCGHRWFGSHNMPAEHAAINLVPQVLDEGVEIPDSCHKCWLRMTAAQFKEVYFALWSHRVLLGEFELMIYSETRMECTRPYAVYYLSTNYEVLDNINFCRVRPTILDCLNGGQTEWKWLSWLGNPN</sequence>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1RM72</accession>
    <accession>A0A098E0J1</accession>
    <name>I1RM72_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG05055.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T16979</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323539.1">
        <property type="nucleotide sequence ID" value="XM_011325237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RM72"/>
    <dbReference type="SMR" id="I1RM72"/>
    <dbReference type="EnsemblFungi" id="CEF86618">
        <property type="protein sequence ID" value="CEF86618"/>
        <property type="gene ID" value="FGRRES_05055"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05055"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16979"/>
    <dbReference type="eggNOG" id="ENOG502STTV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146491_2_0_1"/>
    <dbReference type="InParanoid" id="I1RM72"/>
    <dbReference type="OrthoDB" id="9970537at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025979">
        <property type="entry name" value="ChrR-like_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12973">
        <property type="entry name" value="Cupin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChrR-like cupin" evidence="1">
        <location>
            <begin position="11"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF86618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="123" mass="14246" checksum="251CB7190E5442E3" modified="2012-06-13" version="1">MEQFEFHPATTSHNRTWSPIEPGVDELVLNEDKQTGRRTTLQRWQPGARNQQDVFIHDYVEEIYMAEGDLYDENLQQGWSTGAYAYRKPGMRYGPFRSEGGCLMFIVCIPVDKQGEKEVGEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1RMF5</accession>
    <accession>A0A098E4J2</accession>
    <name>I1RMF5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG05144.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T17205</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323644.1">
        <property type="nucleotide sequence ID" value="XM_011325342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RMF5"/>
    <dbReference type="STRING" id="229533.I1RMF5"/>
    <dbReference type="EnsemblFungi" id="CEF88053">
        <property type="protein sequence ID" value="CEF88053"/>
        <property type="gene ID" value="FGRRES_05144"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05144"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17205"/>
    <dbReference type="eggNOG" id="KOG0324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033441_0_0_1"/>
    <dbReference type="InParanoid" id="I1RMF5"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="6">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="156"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="5">
        <location>
            <begin position="294"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF88053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="575" mass="62891" checksum="6838837D00A21ABC" modified="2012-06-13" version="1">MDVQLFVYDLSRGLARQMSMGILGFQLDAIYHTSIELNGKEYVYDGGIIAIRPGSSHLGQPLQRIPLGKTNLPIDVIEEFLDSLRPIFTLEAYDLFHHNCNNFSDSFVNFLLGKGIPEHIVKMPQAVLDSPMGRMLLPQLTQGINAGRQGGSILGLQESSQAPAAAPKHVIKNIANASEFDRLMGEAKNSCAVVFFTSATCPPCKTLYPIYDELAEEVGDKATLMKVDISQPQQHEIGSRYSIRATPTIVTFLHGKEENRWSGADPAALRGNVQLLVQMAHPVHPHERLRLPTFSNPNAKPVLYTKVPPLDKLMVKMGSEVASKPEVKALKQYLEDRTKNGPSNAVIPDMGHLSSLVKDSVASLPIDIFFTIVDLFRCALSDPRISGFFAEEKSHETVLAVLESVAQKTDCPYALRLVTLQMACNFFSTPLFHDEIMRDSSLRAAIILLVSSSFLDESHNNVRVAASSLLFNLSLANRKARSSSKPTLSGDDELELAASVVEAISLEEKSAEALHGMLLALGHLVYGTSLDGELPDLLQAVGAQDSILAKKSKFPDEKLVTEVGTELLGKGLRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RPI5</accession>
    <name>I1RPI5_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG05956.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T19157</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011324567.1">
        <property type="nucleotide sequence ID" value="XM_011326265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RPI5"/>
    <dbReference type="FunCoup" id="I1RPI5">
        <property type="interactions" value="570"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RPI5"/>
    <dbReference type="EnsemblFungi" id="CEF87870">
        <property type="protein sequence ID" value="CEF87870"/>
        <property type="gene ID" value="FGRRES_05956"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_05956"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19157"/>
    <dbReference type="eggNOG" id="KOG0707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001715_0_3_1"/>
    <dbReference type="InParanoid" id="I1RPI5"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000776">
        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="9">
        <location>
            <begin position="37"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF87870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="223" mass="25260" checksum="9CEBAF014448F829" modified="2012-06-13" version="1">MRWFLGIAKRNSTLPFKHIPTFQVSKRSFTMASPSDRRPIVISGPSGVGKGTLINMLFTRHPDQFTLSVSHTTRNPREGESDGVHYHFVTKDAFRDLIAKDGFVEHAQFGSNLYGTSKATIEEQTAKGKVVVLDIEMEGVKQVKASTIDARYVFVSPPDTEELEKRLRGRGTETEESIQQRLTRAQDELAWARSAEFDKILVNDDLEKTYQELDAFVYTEKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQB5</accession>
    <name>I1RQB5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG06256.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T19877</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
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    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>PH-1</strain>
        </source>
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    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
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                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
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                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>PH-1</strain>
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    <reference evidence="1 3" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="2" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19967"/>
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    <dbReference type="InParanoid" id="I1RQF1"/>
    <dbReference type="OrthoDB" id="5066731at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF86944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="203" mass="22722" checksum="6BAE7EA24E2EEED6" modified="2012-06-13" version="1">MRVHVQQQSPSASQVAEGIYLQQYDNKSAREWEEVFEQFPGHLHWLVKDVTRPLMFGLIPNYPIHCSKAQQYTWVRVLKTALAFGPTKYVRCYHSYGAIGDGRPTSSSSSPEGETPLSPPTLTYRELMANSVPDLVEGKPSVLLSFPGLEELFSAPPNIPGDGGELYSYCMDGRYLASSDFIKQVAYLRQCLIQVLLAEGILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQK8</accession>
    <name>I1RQK8_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG06353.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T20103</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325011.1">
        <property type="nucleotide sequence ID" value="XM_011326709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQK8"/>
    <dbReference type="FunCoup" id="I1RQK8">
        <property type="interactions" value="1210"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RQK8"/>
    <dbReference type="EnsemblFungi" id="CEF87538">
        <property type="protein sequence ID" value="CEF87538"/>
        <property type="gene ID" value="FGRRES_06353"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06353"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20103"/>
    <dbReference type="eggNOG" id="KOG2315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013809_0_1_1"/>
    <dbReference type="InParanoid" id="I1RQK8"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000596">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="217"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="476"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="476"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="560"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="599"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF87538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="676" mass="73843" checksum="0A40319596D4CC17" modified="2012-06-13" version="1">MASPLQFAYRTQKTIGVFDAAPVYEPLAGFNKPEGNLRYCIYSPCGRYFGWASPEVVTVVDASTGQQVLSLPILNVYELGFSPCGTFVITWERPGKDENGDATKNLKVWRVVEEGVAGQDKQPLGRFVQKQQQGWNLQYTADEKYCARLVTNEVQFYESHDLVTVWNKLRVEGATNFALAPGSQNHAVAVFVPERKGQPAAVKVFNVPLFTNPISQKTFFKGDKVQLKWNKLGSSILVLAQTDVDRSGKSYYGETTLYLLSTTGAFDARVSLDKEGPIHDVSWSPNSREFGVVYGYMPAKATIFNHRAVATHSFPIGPRNTITFSPTGRFVLVAGFGNLAGQIDIYDLEKDFRKVTTIESGNPSVCEWSPDSRYIMTATTSPRLRVDNGIKLWHVNGGIMYNEDMIELYNVIWRPQSPESIAPGDPLSPVPTPHSSATALLATAKTPSKPAGAYRPPGARGLATPLHFKREDEGGAAHVVGNGVPNVGPNGFGRPRRGVPGAEFAEQTPTVRTVPGAEPMGDENSSKSKNKKKRNKKNAQGEGGRPQGEPNGGASLAPPSHDRGHEGRSPERRNHRNRSQSRNNQPRSRSNTHRNGHGNQQQAQSSGATAAAAAAAADASQNPNAKKIRSLQKKVRAIEDLEMRLAGGEKLEDTQLKKINTKSSVLKELDGLEKEN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-07-09" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1RQU5</accession>
    <accession>A0A098DQN2</accession>
    <accession>A0A0E0SB56</accession>
    <name>XYN1_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName>Endo-1,4-beta-xylanase 1</fullName>
            <shortName>Xylanase 1</shortName>
            <ecNumber>3.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>1,4-beta-D-xylan xylanohydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">XYL1</name>
        <name type="ORF">FGRRES_06445</name>
        <name type="ORF">FGSG_06445</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2007" name="Curr. Genet." volume="52" first="213" last="220">
            <title>Xyr1 regulates xylanase but not cellulase formation in the head blight fungus Fusarium graminearum.</title>
            <authorList>
                <person name="Brunner K."/>
                <person name="Lichtenauer A.M."/>
                <person name="Kratochwill K."/>
                <person name="Delic M."/>
                <person name="Mach R.L."/>
            </authorList>
            <dbReference type="PubMed" id="17924109"/>
            <dbReference type="DOI" id="10.1007/s00294-007-0154-x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="Biochem. Biophys. Res. Commun." volume="345" first="959" last="966">
            <title>Fusarium graminearum on plant cell wall: no fewer than 30 xylanase genes transcribed.</title>
            <authorList>
                <person name="Hatsch D."/>
                <person name="Phalip V."/>
                <person name="Petkovski E."/>
                <person name="Jeltsch J.M."/>
            </authorList>
            <dbReference type="PubMed" id="16707104"/>
            <dbReference type="DOI" id="10.1016/j.bbrc.2006.04.171"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2012" name="J. Agric. Food Chem." volume="60" first="2538" last="2545">
            <title>Isolation and characterization of two endoxylanases from Fusarium graminearum.</title>
            <authorList>
                <person name="Dong X."/>
                <person name="Meinhardt S.W."/>
                <person name="Schwarz P.B."/>
            </authorList>
            <dbReference type="PubMed" id="22313372"/>
            <dbReference type="DOI" id="10.1021/jf203407p"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2013" name="Plant Physiol. Biochem." volume="64" first="1" last="10">
            <title>A Fusarium graminearum xylanase expressed during wheat infection is a necrotizing factor but is not essential for virulence.</title>
            <authorList>
                <person name="Sella L."/>
                <person name="Gazzetti K."/>
                <person name="Faoro F."/>
                <person name="Odorizzi S."/>
                <person name="D'Ovidio R."/>
                <person name="Schafer W."/>
                <person name="Favaron F."/>
            </authorList>
            <dbReference type="PubMed" id="23337356"/>
            <dbReference type="DOI" id="10.1016/j.plaphy.2012.12.008"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Plays an important role in causing fusarium head blight (FHB) on cereal crops.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="6">0.86 mg/ml for xylan</KM>
            <KM evidence="6">1.7 mg/ml for arabinoxylan</KM>
            <Vmax evidence="6">15.9 umol/min/mg enzyme toward xylan</Vmax>
            <Vmax evidence="6">12.4 umol/min/mg enzyme toward arabinoxylan</Vmax>
        </kinetics>
        <phDependence>
            <text evidence="6">Optimum pH is 6.0.</text>
        </phDependence>
        <temperatureDependence>
            <text evidence="6">Optimum temperature is 40 degrees Celsius.</text>
        </temperatureDependence>
    </comment>
    <comment type="pathway">
        <text>Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4 5 7">Expression is under the control of transcription factor XYR1 and highly induced by xylan.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8"/>
    <dbReference type="EMBL" id="AY730561">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DS231666">
        <property type="protein sequence ID" value="ESU12536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326043.1">
        <property type="nucleotide sequence ID" value="XM_011327741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RQU5"/>
    <dbReference type="SMR" id="I1RQU5"/>
    <dbReference type="STRING" id="229533.I1RQU5"/>
    <dbReference type="GlyCosmos" id="I1RQU5">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T22295">
        <property type="protein sequence ID" value="FGRAMPH1_01T22295-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G22295"/>
    </dbReference>
    <dbReference type="GeneID" id="23553577"/>
    <dbReference type="KEGG" id="fgr:FGSG_06445"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22295"/>
    <dbReference type="eggNOG" id="ENOG502SHCI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020161_1_0_1"/>
    <dbReference type="InParanoid" id="I1RQU5"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <keyword id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end status="unknown"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000429613" description="Endo-1,4-beta-xylanase 1">
        <location>
            <begin status="unknown"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="3">
        <location>
            <begin position="19"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="289"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16707104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="17924109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="22313372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="23337356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <sequence length="354" mass="39336" checksum="A593D4861805182C" modified="2012-06-13" version="1" precursor="true">MAWLQPTLCRKELESRQTSGLDAAMKAAGKKYFGTALTVRNDAGETNVLNTKGEFGSITPENAMKWEAIQPNRGQFNWGPADQHANAATQRGMELRCHTLVWHSQLPSWVANGNWNNQTLQQVMKDHINAVMGRYKGKCTHWDVVNEALNEDGTYRDSVFYRVIGEAFIPIAFRMVLAADPTTKLYYNDYNLEYGGAKTAGAIRITKLIQSYGLRIDGVGLQAHMTSESTPTQSTVTPSRANLASVLNSFTKLNVDVAYTELDIRMNTPANQQKLQANAAAYARMVGSCMDVKRCVGVTVWGISDKYSWVPGTFPGEGSALLWDDNFNKKPSYTSSLNTIRACWKCHRLLVSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>I1RRN8</accession>
    <name>I1RRN8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">FG06771.1</name>
        <name evidence="15" type="ORF">FGRAMPH1_01T23145</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326420.1">
        <property type="nucleotide sequence ID" value="XM_011328118.1"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RRN8"/>
    <dbReference type="EnsemblFungi" id="CEF83547">
        <property type="protein sequence ID" value="CEF83547"/>
        <property type="gene ID" value="FGRRES_06771"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06771"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23145"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="InParanoid" id="I1RRN8"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000102">
        <property type="entry name" value="ABC multidrug transporter Mdr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000009">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000302">
        <property type="entry name" value="ATP-binding cassette subfamily B member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="821"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="892"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="924"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1006"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1038"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="111"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="437"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="776"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1102"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CEF83547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1347" mass="147504" checksum="D6E7A6254B5EA627" modified="2012-06-13" version="1">MADLSEKTAAATSSSNPSRPSSSSRSGSTEQDAVRQDKPNLSDPENEKLDLKKADSAIVVPPKADFIQDQYKHLPSDEAEVLRRQVVSPEVKQGVAVLYRYASRNDIIIIIISSICAIAGGAALPLMTVVFGNLQGVFQDYFVNRSLSSGAFNDKLVQFVLYFVYLGIGEFIVVYISTCGFIYTGEHISAKIREHYLESCLRQNIGFFDKLGAGEVTTRITSDTNLIQDGISEKVSLTLAAVATFVSAFVIGFIKYWKLTLILFSTVIALLLNMGGGSTFILKYNKQSLEAYAHGGSLADEVISSIRNAVAFGTQERLARQYDAHLKNAEYFGFRVKSAIACMIAGMMLVLYLNYGLAFWQGSKMLVEGETSLSNILTILMATMIGAFNLGNVAPNVQAFTNAVAAAAKIFNTIDRVSPLDSSSDAGQKLEQIEGSIRLSNIKHIYPSRPEVTVMQDVSLDIPAGKVTALVGASGSGKSTIVGLVERFYDPVQGTVYLDGHDISKLNLRWLRQQMALVSQEPTLFGTTIFNNIRHGLIGTAHEAANEEKQRELVIEAAKKANAHDFVSALPEGYETNVGERGFLLSGGQKQRIAIARAVVSDPKILLLDEATSALDTKSEGVVQAALENAAEGRTTITIAHRLSTIRDAHNIVVMSEGRIVEQGTHNELLEKKTAYYKLVSAQNIAAAEEMTAEEQAAIDEEEVELMRKMTSEKATATLADPNDDIAAKLNRSTTSKSASSLALQGHKAEDEREYGMWTLIKLVASFNTTEWKLMVVGLVFSAVCGGGNPTQAVFFAKQIVTLSQPITDNNRHSVKKDSDFWSAMYLMLAIVQFLAFVIQGVLFARCSERLVHRVRDRAFRTMLRQDVAFFDRDENTSGALTSFLSTETTHVAGLSGVTLGTLLMVITTLVSAMVVSLAIGWKLSLVCISTIPVLLGCGFFRFYMLAHFQRRSKAAYDSSASFASEAISAIRTVAALTREEDVLNQYKNSLAIQQRKSLISVLKSSLLYAASQSLLFACFALGFWYGGTLIGKLEYTMFQFFLCFMSIIFGAQSAGTIFSFAPDMGKAHHSAGELKKLFDRQPIVDTWSDKGERLPEVEGTLEFRDVHFRYPTRPEQPVLRGLNLTVRPGQYIALVGASGCGKSTTIALLERFYDPLSGGVYIDNHEISTLNINDYRSHIALVSQEPTLYQGTIKENILLGTPREDVTDADLEFACREANIFDFIVSLPEGFSTIVGSKGALLSGGQKQRIAIARALIRDPKILLLDEATSALDSESEHVVQAALDKAAKGRTTIAVAHRLSTIQKADIIYVFDQGRIVEQGTHTELMKKNGRYAELVNLQSLEKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1RRQ2</accession>
    <name>I1RRQ2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T23189</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326438.1">
        <property type="nucleotide sequence ID" value="XM_011328136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RRQ2"/>
    <dbReference type="STRING" id="229533.I1RRQ2"/>
    <dbReference type="EnsemblFungi" id="CEF85464">
        <property type="protein sequence ID" value="CEF85464"/>
        <property type="gene ID" value="FGRRES_06787"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06787"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23189"/>
    <dbReference type="eggNOG" id="ENOG502SQ74">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038389_0_0_1"/>
    <dbReference type="InParanoid" id="I1RRQ2"/>
    <dbReference type="OrthoDB" id="5383784at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF85464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="523" mass="58982" checksum="192F979FDC1B966D" modified="2012-06-13" version="1">MGMQGPLTAQALGRSPYDDVVEWEDDHDDQQNGDGSTQQFDHRGRPINPETKKINRDIIRSHNEVMLVIGVAEQENPTSSPEAESDKRHALYEDDVGRNLAFSAFRCVDAAGAFGLDGFRQRILIYKRYSHIPFWDLYAKSQNPFSITRYILPGASLNLLSHYADRQVASLWQDRPDRQFSRRLVHEVWSYVRVHLELFVALQRLGLVSSTSWLPSFSFFIPFTQDSPILAPPPLAGLSFQSILQWAGGLFISSTPFLIWVITQRLIRDWWPQIMGRIYRRLPNTGSPLGMTSTWTSADRPRERPEHRRNRSTVEDVSPIRPIDGQMPSDTGPVEAVRRPSTFSARGDDYASDEEDNEAVSATLISFDVEATAETSEAPPGLWSAELRPSVDARGAVMPTTTYCDTMLTQIPPLIASHVFADAVLRLAIAPWEATALRLVAGTFRQRFGLPTNDICGINLLGESNLVFAINFLGSQVLHLAVCGEIWATFTAIATIFHTTPEEWREAEEEEQENRQDWPDERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I1RS50</accession>
    <name>I1RS50_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial inner membrane protease ATP23</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FG06960.1</name>
        <name evidence="11" type="ORF">FGRAMPH1_01T23609</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Has a dual role in the assembly of mitochondrial ATPase. Acts as a protease that removes N-terminal residues of mitochondrial ATPase CF(0) subunit 6 at the intermembrane space side. Also involved in the correct assembly of the membrane-embedded ATPase CF(0) particle, probably mediating association of subunit 6 with the subunit 9 ring.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Peripheral membrane protein</topology>
            <orientation evidence="1 9">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M76 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011326637.1">
        <property type="nucleotide sequence ID" value="XM_011328335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RS50"/>
    <dbReference type="FunCoup" id="I1RS50">
        <property type="interactions" value="505"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RS50"/>
    <dbReference type="EnsemblFungi" id="CEF84020">
        <property type="protein sequence ID" value="CEF84020"/>
        <property type="gene ID" value="FGRRES_06960"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_06960"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23609"/>
    <dbReference type="eggNOG" id="KOG3314">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079125_0_0_1"/>
    <dbReference type="InParanoid" id="I1RS50"/>
    <dbReference type="OrthoDB" id="285308at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019165">
        <property type="entry name" value="Peptidase_M76_ATP23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711:SF0">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE ATP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09768">
        <property type="entry name" value="Peptidase_M76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CEF84020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="262" mass="29904" checksum="B7B1DD5F77B48E8C" modified="2012-06-13" version="1">MSSDPTNAPSATAGASTTTDQVPRGIQNNPAVTGFSPEVSKWMNYFKMISGQMTPEGKFHYREWVHTVEEEKDIKRCEEFRDWLFTYSPTVRFMSEKIRDLNGRIDSSNVYCRRCPSYLNADGTVLRQSGGFSPEHGILICANEIQSRKHLEDTLAHEMVHAWDTLRWKNVDFVGKPGNLKHAACTEIRASMLSGECRWAKEAFTRGNWKLTQQFQNCVRRRAIDSIVGRTACKDDVEATKAVNSVWDSCFADTRPFDEVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RSZ1</accession>
    <accession>A0A098DQZ8</accession>
    <name>I1RSZ1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG07278.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T24407</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327019.1">
        <property type="nucleotide sequence ID" value="XM_011328717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RSZ1"/>
    <dbReference type="STRING" id="229533.I1RSZ1"/>
    <dbReference type="EnsemblFungi" id="CEF84280">
        <property type="protein sequence ID" value="CEF84280"/>
        <property type="gene ID" value="FGRRES_07278"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07278"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24407"/>
    <dbReference type="eggNOG" id="KOG2319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017705_0_0_1"/>
    <dbReference type="InParanoid" id="I1RSZ1"/>
    <dbReference type="OrthoDB" id="10264848at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF97">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="241"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF84280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="724" mass="79099" checksum="89BA9CB916810472" modified="2012-06-13" version="1">MIVYSPNQRSMASRNPSESSPARPSATRIASHSHTSKTPTDTTGDRLAVPAVPKRAHTFANATPSLDDSATSPDAFETGEHSDSEDGIEVTRASVELDILPIELITLTDSFIESLNAKVHPTPPNIENLSQKFQDFYTQASSNINTHINALASRQSRDASPTPSISSISSAASRLRSKATALSITKAEPEQQMITAEELANRKRNRKALEAKRSLLEEAVERRLCEGIYDKIWRHRSTQDEAHDDKLRSKTAALALVGIGPSDLGIDLTGEADESGEKTRPTEHDIKEKLEPARRDIIMMTQKRYPLGKLNHLKAAHRSIVDTLAHFHPSASADEIMPMLIYTLITLPPENLHVISDVHFIQYFRWEPKLTGEAAYCLTNLEAAISFLQTVDLATLRADEQLSGPTKSTLQRTETFPPAYQQGEVSASLDVPKEGKADADAVKISAPDVKASQVLRNRRLSDLINGPTQAFGAASDAVFNTADQGLKNISNSLEGSYKFLVGKLREHQDSPRESITVPRTLEDARKLVSTPSPDEEDTTGLNRLVVLDDADPLKRPASREDRVLNLIGGLRDRSTDSTRSGRSASSSKKVLFAAEEPKAASQTPSQNPAVLDQMRNLGNSFNPMARLPSISMIRGFGRNTPTTPPVPTAKETVKPADGGDLGTAFPDIAPALPPKEIPKIAPPNKRFMELQTPGELKLGEVLDLLRDYRRLANALKDVGAFETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I1RTU7</accession>
    <accession>A0A098DR43</accession>
    <name>I1RTU7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG07614.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T25219</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327399.1">
        <property type="nucleotide sequence ID" value="XM_011329097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RTU7"/>
    <dbReference type="EnsemblFungi" id="CEF83819">
        <property type="protein sequence ID" value="CEF83819"/>
        <property type="gene ID" value="FGRRES_07614"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07614"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25219"/>
    <dbReference type="eggNOG" id="ENOG502S5VZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051118_0_0_1"/>
    <dbReference type="InParanoid" id="I1RTU7"/>
    <dbReference type="OrthoDB" id="5342093at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF4">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="13"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF83819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="281" mass="31201" checksum="79BC65D24DB849DA" modified="2012-06-13" version="1">MNNAPRKHYIDGFPSLANFIASDRDGTSTIFKRFNRLAARNLLNLQSELAELEAKLDAFDDQDRESRESLQSLRNWKDFKDRNDEDSERRKLLRDIKSTFKEYREALMFESTLATIPPPDRKTLKAFRTNFFHGRPGEAGAFPMLGGHSSSLYDDSDDLLVLHSREPPDRLTMFVQDNFGYLFEESGTANGSSIAYASGKKISTFISYISTVLAAVLLIGAIVILYNINSDNLKLGLIALFTVLFSASVGLLTNAKRAEVFGATAAYAAVLVVFVSGDLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>I1RTV5</accession>
    <accession>A0A098DSL9</accession>
    <name>I1RTV5_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FG07623.1</name>
        <name evidence="9" type="ORF">FGRAMPH1_01T25239</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327409.1">
        <property type="nucleotide sequence ID" value="XM_011329107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RTV5"/>
    <dbReference type="EnsemblFungi" id="CEF84362">
        <property type="protein sequence ID" value="CEF84362"/>
        <property type="gene ID" value="FGRRES_07623"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07623"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25239"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012737_0_0_1"/>
    <dbReference type="InParanoid" id="I1RTV5"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="404"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="869"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="782"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="815"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF84362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1000" mass="110277" checksum="EE77AAE394F5F139" modified="2012-06-13" version="1">MHFFPTADSTLLSSTVDYHSLPPRPKAVGPIFDANNFKTPVDPWDSDDQTNLYPPKDDPFDPSAIPAEPSCPSSRYPRSRLAKNERLRLSMLWYYTRDLDEHPELLAGLQEKACLAQENSGWEYAVVGLLDINVYIRLATVGLQLAILPRGETLCAHTVTQPPGNVFLLPNMLEDWRYRESPYVEHGGLIAYAGVPLRIQHESGESVGLGSLCVASATSKPPLTKHQQLALARLGDWIVADIVQCARARRQRERHRLTDLITTLLREPEGDDVQEPILHILRQAYPDESVTLQFTGTDSYDTTVPYAASDPKHGLWEDDEYIDNFILTSNCNDPPTDRVVRFISAQCESKLGPSVLVVATKDFRRIFDDVDSGFVQACATMLTQRWQKRLLSEVMRAKEKFLRGVSHQLRTPIHGILGAAELLTEHLKALTITGCSKLPPPGVEELIQPLAELGKSSVYLDTISTAGRELMSTVNSMITLNRWADIASAERQYATHSIQELEDILVKGSSDITLRDTSKRAPIFFHHDLPPCCQSLRIDVELFRDSVLPLIVNAIQNTFEGIITVTLSYIQDTKTLVVDVQDTGCGIAANDQGRIFQLYEKVGEHSTGPGLGLTLASKFSALLHGSVELVSSEVHRGSHFRGTFGDIRSIPSSTPFLPIASQLKRLPLSFHHLTSDSPEIHLNSHLSKYLTCNGFVQSDDSADCLIVMDYIRDPDQRQKYHATLPKGQVAICPVPDMEDIENSPSTSNIVFVRGPFCTSSLDAGLREADELCAMAPRTITTPLPLASPSLTRDGRGILPYRPSPSGHNSTDEGYGSNTTPSNNGSPIPQARTEESLSTSNESAPAVPAASKTPPPDVPVRTLPNTYKPMTLLVDDNAVNLRILEMYCKKRGLPYRSAIDGQQAVNLFHQQQSPTSSDPPFDLILMDLQMPVCDGISATTQIRSLEKTGDKTSVLFIITGQDSQKDREAASAAGADNYLVKPVGIKMLDGSLKRYFPDLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1RU84</accession>
    <accession>A0A098DSN7</accession>
    <name>I1RU84_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG07768.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T25605</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011327583.1">
        <property type="nucleotide sequence ID" value="XM_011329281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RU84"/>
    <dbReference type="EnsemblFungi" id="CEF84871">
        <property type="protein sequence ID" value="CEF84871"/>
        <property type="gene ID" value="FGRRES_07768"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_07768"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G25605"/>
    <dbReference type="eggNOG" id="ENOG502SYK3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045417_0_0_1"/>
    <dbReference type="InParanoid" id="I1RU84"/>
    <dbReference type="OrthoDB" id="5042061at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="258"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF84871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="392" mass="43829" checksum="7EF4FFE7C0FABF5B" modified="2012-06-13" version="1">MLNININKSTPAVIEWPSGDTTHLLVEPDPKYASITFTTRFDATTSFFELSIPIKIKHTRLKDDTEGDNSVSALLLRICSSTVDTLSFASSTKPPNAVQKKLASRTTRLDFQLDRTVDALVPKNAHEPLVPARGQSGLVLDAVRQISNTTTLSVYIQDAILSNTQLQSIRDACGQGCSKPVCRDDHHFSSLYGGNGAKVIRLSAETGQLPPSYNKIGSPPPSAPINPLKRRRQDSEAERSDAATELQALLGKMEARMLAKMEERLKGLDYEKENSRESLAKRIEELENENRRLKESMEERVKGLESENQHLREGIDKLRALLENQSDDIDRVGEQTSENTAELVTIDDELTHVRHDVDELVVKTDSLERGDLVEMVKSDVLEYIRIRLWGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1RUU5</accession>
    <accession>A0A098DCS1</accession>
    <name>I1RUU5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T08875</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF76240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320832.1">
        <property type="nucleotide sequence ID" value="XM_011322530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RUU5"/>
    <dbReference type="STRING" id="229533.I1RUU5"/>
    <dbReference type="EnsemblFungi" id="CEF76240">
        <property type="protein sequence ID" value="CEF76240"/>
        <property type="gene ID" value="FGRRES_08001"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08001"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08875"/>
    <dbReference type="HOGENOM" id="CLU_1906915_0_0_1"/>
    <dbReference type="InParanoid" id="I1RUU5"/>
    <dbReference type="OrthoDB" id="5326346at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF76240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="133" mass="14978" checksum="80C030B5B6E88361" modified="2012-06-13" version="1">MSTTTRITIDDEGDTLIILKLRSDDSNPDVTDIIATADESTIETTTETTATSNVTTDDAVQSEDRPHTEEHFLCSKKHLSFASRRASKMFLSNFKEASKEEDGLHHWTFEALFQPTAFEIVLNFIHGKTRDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1RX63</accession>
    <accession>A0A098DEI2</accession>
    <name>I1RX63_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG08913.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T11161</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319789.1">
        <property type="nucleotide sequence ID" value="XM_011321487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RX63"/>
    <dbReference type="STRING" id="229533.I1RX63"/>
    <dbReference type="EnsemblFungi" id="CEF77383">
        <property type="protein sequence ID" value="CEF77383"/>
        <property type="gene ID" value="FGRRES_08913"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08913"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11161"/>
    <dbReference type="eggNOG" id="ENOG502SQKQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037532_0_0_1"/>
    <dbReference type="InParanoid" id="I1RX63"/>
    <dbReference type="OrthoDB" id="4146887at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609:SF1">
        <property type="entry name" value="RFEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609">
        <property type="entry name" value="RFEG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF77383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="313" mass="33048" checksum="BB62301A068F5CAB" modified="2012-06-13" version="1">MSRSSRNPAPAAAGTGRQNEYFVPRDGIDREVISADICRYLGNDALVRPGHYENPQTGQAVQGYYITAYRNLTTAMIEDLKADSARWDSERRAQTSRNTSGGTIASRNVGVPPRHSSNSPVVQYRYSETHQSRQHHGPTEGPYATDPYARDSGFDGGPRYPGTGAPGYTGAAGSYSQSYGGSSSGFAGYAQAQQSPPPADARFSSTPAAAVMNTPYTAGQSPYVDVGTNQRPRGYDAYANQAAAAAAAAAAQQQAYATSAPSQPGYPATAAYQYSGQAPPTGYTMQPQDPFYGRGAYSGGPDGQVCKDKVLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I1RXQ1</accession>
    <accession>A0A098DST2</accession>
    <name>I1RXQ1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG09125.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T27869</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328663.1">
        <property type="nucleotide sequence ID" value="XM_011330361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RXQ1"/>
    <dbReference type="SMR" id="I1RXQ1"/>
    <dbReference type="STRING" id="229533.I1RXQ1"/>
    <dbReference type="EnsemblFungi" id="CEF84427">
        <property type="protein sequence ID" value="CEF84427"/>
        <property type="gene ID" value="FGRRES_09125"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09125"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27869"/>
    <dbReference type="eggNOG" id="KOG4169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_13_0_1"/>
    <dbReference type="InParanoid" id="I1RXQ1"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF84427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="287" mass="31126" checksum="47384E9B5D237564" modified="2012-06-13" version="1">MSPSLDAPTDASSPRLSVIVTGGASGIGLAITRHFASQGHMVAVLDVNSKTGPDVVAQVAKEYPKATVSFKWCDVSSWEGQYAVFDQAYREHGDRIDIVIANAGISDPVVGALDCVPTEFPRKPQLRMQDINLNGVIYSVSLAVHYMLKNEIGSRLPDSRGSIVCTSSSAAFYPFPVSPLYSTSKAGIVGLVRSMAVRLQEPKIQINALAPGALETNIAPDKELFRFMVITPMSTLIRAVEQFVTDPSRSGQIAELNEEEITLRPHVEYANAGAEHNNKMFWKLGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1RY33</accession>
    <name>I1RY33_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG09264.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T27523</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328504.1">
        <property type="nucleotide sequence ID" value="XM_011330202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RY33"/>
    <dbReference type="STRING" id="229533.I1RY33"/>
    <dbReference type="ESTHER" id="gibze-q4i0j4">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF84180">
        <property type="protein sequence ID" value="CEF84180"/>
        <property type="gene ID" value="FGRRES_09264"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09264"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27523"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027519_0_0_1"/>
    <dbReference type="InParanoid" id="I1RY33"/>
    <dbReference type="OrthoDB" id="5354320at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF25">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="154"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF84180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="474" mass="52627" checksum="A65EC8DE22E97094" modified="2012-06-13" version="1">MNLETIRIVVPLLPLILRQSFLHVLHLSDASKHLDLRSALIIACLRVILTPKTPRSISAVQELTLRDPGIKGRIWVSKYASPPPPETSIRDALIVALQHTGDSTCRVPVPDLVDVEAEWTGYRSGVSSGAPLPDVSERERYHGMMRDCKRPTTVLYLHGGAYYLCDPATHRTTTKKLAQLTGGRCYSVRYRLAPQHPFPAALLDAFVSYFTLLYPPPDAYHDPVQPEHIVIAGDSAGGNLSLALLQLILELRRQDSPILWYGELRQVPLPAGLALNSPWLDVTQSSPTWEASTPTPFDYLPKPENVDQLAIPPCKAWPANPPRRNLYVADELAAHPLASLVMARSWKGAPPIYLCTGWEILAYEDKYLARQLEADGVRVVFEEYEGMPHCFAMMLRNAPATPRCYNGWASFISAAVENPGGIESSAVMIKSKTCEEAPLRFDQLSDASEEEFRQRVLHKTGLADGDIEIPMAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I1RYC8</accession>
    <accession>A0A098DQM1</accession>
    <name>I1RYC8_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fumarate reductase</fullName>
            <ecNumber evidence="4">1.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FG09373.1</name>
        <name evidence="6" type="ORF">FGRAMPH1_01T27243</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Irreversibly catalyzes the reduction of fumarate to succinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328372.1">
        <property type="nucleotide sequence ID" value="XM_011330070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RYC8"/>
    <dbReference type="STRING" id="229533.I1RYC8"/>
    <dbReference type="EnsemblFungi" id="CEF83632">
        <property type="protein sequence ID" value="CEF83632"/>
        <property type="gene ID" value="FGRRES_09373"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09373"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27243"/>
    <dbReference type="eggNOG" id="KOG2404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011398_4_5_1"/>
    <dbReference type="InParanoid" id="I1RYC8"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF12">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0274">FAD</keyword>
    <keyword evidence="1 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="5">
        <location>
            <begin position="47"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CEF83632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="512" mass="54028" checksum="92528781801C1E9A" modified="2012-06-13" version="1">MSRPQLLFLSCIGFAVALTAMLYSNIIHSSTLTSVLSKSMSSSVRPIVVVGSGLAGLSASYEALQRGAPSVHLLDRAPKPGGNSIKASSGINGAGTKYQRAAGVESDTTFYSDSVRSAGSRFHLAQPPVDREGLVTKLTTESAAAVEWLVDEIGVDLSVVAPLGGHSVARTHRGAGKTPPGAAIIIALLNKLKENKKFSITNLAEVKALLRENDEVKGVEYEFEGQKHNLEGSVLFASGGFAGDATGLLARYRPDLKGIPSTNDERPGSHDILTSVGAELLDMDSVQIHPTGFVDPASPNTMLKFLAAEMLRGEGGILLSPDGSRFVNEMDTREHVSNAIMKLPTATDGDGVIKQWDITILLDPGASAASANHISFYEWKGLLKKVKVRDLTSAQIAAVDKYAQSVADGSADEFGRTQRGRWTLPAGEKNRDQDIYIGRVTPITHFTMGGVAIDEKARVLKKSGDKLVPIPGLFAAGEITGGIHGDNRLGGSSLLECVVYGRTAGAEIVGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I1RYN7</accession>
    <name>I1RYN7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T26945</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011328224.1">
        <property type="nucleotide sequence ID" value="XM_011329922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RYN7"/>
    <dbReference type="STRING" id="229533.I1RYN7"/>
    <dbReference type="EnsemblFungi" id="CEF85395">
        <property type="protein sequence ID" value="CEF85395"/>
        <property type="gene ID" value="FGRRES_09495"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09495"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26945"/>
    <dbReference type="eggNOG" id="ENOG502QVTM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008152_1_0_1"/>
    <dbReference type="InParanoid" id="I1RYN7"/>
    <dbReference type="OrthoDB" id="338531at2759"/>
    <dbReference type="PHI-base" id="PHI:1299"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000021">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit rsc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="6">
        <location>
            <begin position="16"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="RFX-type winged-helix" evidence="7">
        <location>
            <begin position="642"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="207"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF85395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="942" mass="106302" checksum="B5A1A6E0618433A3" modified="2012-06-13" version="1">MAPVRNEVPPHTIDRTPEYEEFMTRLRDYHSKRGTILDPEPKVGATHLDLMKVFNHIVESGGYDKISEEKLAWRRMASELGIYSNNEASTAFSLKEKFYKNLAAYEISTVHGKEPPPKDILEDVTAKGASLLTRTRENYRGTKRESNIGATDSAASGDDGTPVRERPVPDAAASARASRGLREAPPQRVIFQPDTGPSRTTRHSSAHHATTTNSPAANPSQTPSHHPNMHVPQQHPQQQQQQNYQGNRGPSIHHHPTNTENTSTLVTAYQPRFSKPLTLRAVPTPSNAPAEFQKLRQLPRLDSRQPMQPGTGFDGPNIYMRCLNALRSNIPTEQAFALNHLVKISFERGDKYKFDSFPGLAEGLVDKALEVGQLFYHVNWTVSWNIPHDSSDPSVLDGNYGTPDILERIDNLIEKDVPDVLQTEAYADNLVLITEAVLTLRNMVTLPENAHNMSDFPPIKDLICIVLNLPQRDSLVELKHLTLDIAEQLTPFMTLDSDDPLYRVLLAQMSSEDRGTILTALRALGRISMNLEATNKLGNVPGPVLQRLASWLLLNDDELIDACLDFLYQYTAVVPNVDTLIRSLTPENLVDHLARLLAHGARKTQRELVLVSEQRIPARDQIAPMPEDLLQEMLKLEEPDRVHRWVRCFFEEDNSSYVTQLAAWQAYQTAFVGPLKNIGQPLITPADFIRNSTSVYKDSNAQVLRDPGDPQQKFIIHGIRARPKPLGMDGKEYGRCLWASNPDNMLEKCGHFYIQAEKMWEHILTDHLHEKRNEKGQFDNVEKGFTCTWDQCSRFQKPTKLRLQEFSRHINTHVSLALPSEAHSRKSERSWIIPAKTMTVAFEETMTARDERNPNLPPQAAGIPLSAALVLRNIARNVVKTEAEEEMLKGQAETGESGGWNEILFRPLMPRLFEILTENRAMSPYISSLLDLIRVHNEDRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I1RZM3</accession>
    <name>I1RZM3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG09872.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T06725</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011318774.1">
        <property type="nucleotide sequence ID" value="XM_011320472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RZM3"/>
    <dbReference type="STRING" id="229533.I1RZM3"/>
    <dbReference type="EnsemblFungi" id="CEF75167">
        <property type="protein sequence ID" value="CEF75167"/>
        <property type="gene ID" value="FGRRES_09872"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_09872"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G06725"/>
    <dbReference type="eggNOG" id="ENOG502QRZN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005335_0_0_1"/>
    <dbReference type="InParanoid" id="I1RZM3"/>
    <dbReference type="OrthoDB" id="445341at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057088">
        <property type="entry name" value="GLRG_09195_Thiored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF5">
        <property type="entry name" value="ISOCHORISMATASE FAMILY PROTEIN FAMILY (AFU_ORTHOLOGUE AFUA_3G14500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24470">
        <property type="entry name" value="Thiored_Isochorism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="550"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="822"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF75167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="933" mass="103005" checksum="2D787FAEC7B9F061" modified="2012-06-13" version="1">MFSFDQASLPQITTRKALIGVDFQEDFISKDGALPVNEPEGFVERTVKLSEAFRDVGDVVWVQSQFSETRHAPEEDIVITDKAPKSAQGFSRGRPSPPEKIIEAGGPPDKEAFLSHEDAVCVKTDTPGCRIASVIQDSMHKTDAKLFKSHYSAFQSTHLLRVLRAKMVMELFICGSLTNVGVYATALEAAGHGMAITIVDDCCGYRTESRKSAAIASLIELTGCEIASYDEVMEVIQPKPKPPKSRNARHPTPSKVLEQAETVKPGSKEVKGREKSTTPDFVKDMTSLRLASDLPSPALSSTTSPPKVLPTGVVEGHDSKTKLPKTKEPDSVNQAMASGAPDVAQLENSSTNGKIPDAVEDRADQATTLLQSTDEVSVINSYRSEGSVKDKDEDHRDQPSASANKIQSEPKPIQTTPALNDKQNEEKTKESTTPTRKMQETPEDKKTMESYDDNLGKRGLCEGDTDIIENALPDSLADGIFDKLRGEIQWQHMSHQGGQVPRLVAVQGEVGSDGSIPVYRHPSDESPPLLPFSPIVQAIRTETEKHLGHPLNHVLIQYYRDGTDYISEHSDKTLDIVKGSYIANVSLGAERVFTFRTKRKDKDAAQDEASSPIDSKRTIQRAKLPHNSLCRLGLCSNMKWLHAIRQDKRPKKEKSEAELAFEGGRISLTFRHIGTFLNREETLIWGQGAKAKTRDESRPVINGQSSEAIEMLKAFGTENHATEFDWDAHYGKGFDVLHMSNAPRFFACRDPITNMRIALMLAEFGVNHAKGSITTGSEPLNSDNLVVKLMDKDKSVVQGDFAVMLYIDARYGIGISGSTLQAPAVLATRLTRFQRAMTFLDTWRNLPKADDNGTRDIKSLKHELEVWDGFAEDDAQPFIAGTEMSLPDFAIWPVLHSMVEEAGLNIFDGLENLRAYYGKVGERPSTRKMLGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I1S0D5</accession>
    <name>I1S0D5_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RAD52 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FG10158.1</name>
        <name evidence="8" type="ORF">FGRAMPH1_01T07419</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319098.1">
        <property type="nucleotide sequence ID" value="XM_011320796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S0D5"/>
    <dbReference type="STRING" id="229533.I1S0D5"/>
    <dbReference type="EnsemblFungi" id="CEF75514">
        <property type="protein sequence ID" value="CEF75514"/>
        <property type="gene ID" value="FGRRES_10158_M"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10158"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07419"/>
    <dbReference type="eggNOG" id="KOG4141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011431_4_0_1"/>
    <dbReference type="InParanoid" id="I1S0D5"/>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004585">
        <property type="entry name" value="DNA_recomb/repair_Rad52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00607">
        <property type="entry name" value="rad52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="244"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="364"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00077224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CEF75514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="519" mass="55014" checksum="31D801A0DAF1B196" modified="2012-06-13" version="1">MPAPGDQHSVVTNPYEEPRPRIAEWAAKDIATISAKLDKQLGPEYISARAGPGGTKVHYLTAEKCITLANEVFGFNGWSSSIQNIQVDFADENPQTQRFSVGLSVIVRITLRDGTYHEDVGYGSIENAKGKAMAFEKAKKEGTTDGMKRALRNFGNVLGNCIYDKDYVKQVTKIKAEPVKKFDQDNLHRHSDFIKRDVARAGPAAAAPAPLAAPVVKTEPAPPLPVAESFDDYLGELDEADFCVPEDGHPDEIMLSTSILGQPGNEKPASNPHAQRNQQQPSRSNSTGPPNRAPQTPIQGQQRSNPSNGPNALANRPQGGPSGRTTPNQIGNPRPPPNVPQNIPETVGFFSAKAVSQLPEFTIEGSGSGALALPQGQQAFNPKAESPSIRKTPGIDHNSSKPVSRNGQHVAPTSSQANAAPAPRSNPNSFTPVRPSMPSSQSARGNVINPSLDQTRRIGAPSGPGSPLANRGSYRPPAMKRPPPAADGRTALADLPANGNGGATSTVTAGLDAKRQKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1S0V8</accession>
    <name>I1S0V8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG10348.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T07885</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319314.1">
        <property type="nucleotide sequence ID" value="XM_011321012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S0V8"/>
    <dbReference type="EnsemblFungi" id="CEF75746">
        <property type="protein sequence ID" value="CEF75746"/>
        <property type="gene ID" value="FGRRES_10348"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10348"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07885"/>
    <dbReference type="eggNOG" id="ENOG502S2WH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016578_0_0_1"/>
    <dbReference type="InParanoid" id="I1S0V8"/>
    <dbReference type="OrthoDB" id="5413982at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1"/>
            <end position="252"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="475"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="48"/>
            <end position="75"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="91"/>
            <end position="112"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="114"/>
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            <begin position="155"/>
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            <begin position="226"/>
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        </location>
    </feature>
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            <begin position="378"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF75746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="582" mass="64620" checksum="BA86A7171BD00D73" modified="2012-06-13" version="1">MADAEEKARKEKIAAAKKRVEQMKKKKKGAPAKQTKTEAAETPAPEPAEEKTEDTPAVEEKPAEEPPKNTDDKPAKASSKGPKKPLKIETKDEDESDSDSDSDSESESDDENSPAATPSLAQQSKLRSTSFRAGSNPSGGAASPFSPDGETAPDIYRKHMARIEELEKENKRLSKEATDSEKRWQKAENELADIREAEGEESGKTGSHDDGLLDSLKSQMAALERQNAQLQQQVSRGPSHGHRQSVSMATPPADFKAELEAKTATIESMEIEISKLRAQAERHASGSSSEKEQVTALEDKLARAEAAAGKAQRELQDLKRNLERTAEKAVREGSERTSAETKVKTLEHELEEVKNARDELEKKVEALDKKATTLTTLHKEQDSRLQAVKKEKEKAEHQVTELQEKVEKLESENTKLKSRKSLEGGGGLDDEGVDELEDEERQKLERKIRALESEVHELRSGAWIEKRRELEATSPGFQDVDLTTGHGMSPTQRRKSGPGGIGDFFTSGLNALAGGGDDEFLEDDDMDFDEDAFRKAQEEESKRRLERIKEIKRSLKHWEGWRLDIVDIRRGGNEGVGEIFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I1S128</accession>
    <name>I1S128_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FG10422.1</name>
        <name evidence="12" type="ORF">FGRAMPH1_01T08067</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="12">PH-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319396.1">
        <property type="nucleotide sequence ID" value="XM_011321094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S128"/>
    <dbReference type="FunCoup" id="I1S128">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1S128"/>
    <dbReference type="EnsemblFungi" id="CEF75837">
        <property type="protein sequence ID" value="CEF75837"/>
        <property type="gene ID" value="FGRRES_10422"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10422"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08067"/>
    <dbReference type="eggNOG" id="KOG3996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048602_1_2_1"/>
    <dbReference type="InParanoid" id="I1S128"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="25"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CEF75837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="268" mass="30257" checksum="696F0262776F9B8A" modified="2012-06-13" version="1">MADKNDACPVDHKTRDAWLAQAREAEAAKAKAQPEKCPVDHTAQQQQPKSWTQTFTSYLWSSPASSSTPAHKPTSNDGLDTDRVVSTIPRTTGDATACPVDHEKEPARPKNHEMETGMDPSGNWVYPSEKMFFEAMKRKGYDARVADMKTVVPIHNAVNERAWKEIKEWEAPYLEGTTCGGPKLESFANKMDRMTPTARIKTMIGYTAPFDRHDWVIDRCGTRVDYVIDFYAGRPDGRGGPSFYLDVRPKLNTWEGVKMRAKRWAFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I1S187</accession>
    <accession>A0A098DD90</accession>
    <name>I1S187_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG10487.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T08225</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319473.1">
        <property type="nucleotide sequence ID" value="XM_011321171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S187"/>
    <dbReference type="EnsemblFungi" id="CEF75916">
        <property type="protein sequence ID" value="CEF75916"/>
        <property type="gene ID" value="FGRRES_10487"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10487"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08225"/>
    <dbReference type="HOGENOM" id="CLU_956588_0_0_1"/>
    <dbReference type="InParanoid" id="I1S187"/>
    <dbReference type="OrthoDB" id="10666047at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF75916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="291" mass="31919" checksum="D0D4749B77C2C582" modified="2012-06-13" version="1">MSMPALTVGPGLRCNIDTTWFAKVACLLSSGLPYAAEITHIQRLNPGWRATSIIELYIWLSVDPGSLSSIYTIPSVAEYMDVAEGGLGSGYWAKPRHDGKPFGFAAALSRGWVTSNYQKFNDLVAYISDVQNMAIESFGVLSTWNGISRVYHCLTSRTSVMRKVHALERQDLIEEMRISCMASDITRLPTLPQLMGPPSPHDCTVAYIELGSAPLCVLLGVSTEQKDRWLLQNETSSQHACIHLGVLNTVGKSDVGTQIEKVVCTNSLGCHNALKAIVSQWPMLTQQDNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I1S1C9</accession>
    <accession>A0A098DAI0</accession>
    <name>I1S1C9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG10529.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T08339</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319523.1">
        <property type="nucleotide sequence ID" value="XM_011321221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S1C9"/>
    <dbReference type="STRING" id="229533.I1S1C9"/>
    <dbReference type="EnsemblFungi" id="CEF75973">
        <property type="protein sequence ID" value="CEF75973"/>
        <property type="gene ID" value="FGRRES_10529"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10529"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08339"/>
    <dbReference type="eggNOG" id="ENOG502RY8Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045137_0_0_1"/>
    <dbReference type="InParanoid" id="I1S1C9"/>
    <dbReference type="OrthoDB" id="194289at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021836">
        <property type="entry name" value="DUF3429"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11911">
        <property type="entry name" value="DUF3429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF75973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="493" mass="55349" checksum="05E7DB40D272839B" modified="2012-06-13" version="1">MFRTSSRPLWQLAARASPNKTSLPRASIAPLLRQQRAVYSSKSDPENPPPPKQPIDYEAERKRGQELLQSDPKHVSSKSSLSNTAGVQGPTKGEESMGNELKHDIEVVKDTFTFTNVPRESRILGLAGTLPYLGTSLSTVFLAWNLNKDLPTGNSLYDAIMVDHETAKYMLSVIEPLQLGYGAVIISFLGAIHWGLEYAEKSPSLRRTRFRYGMGLASSIIAWPTVMLPIEYALTTQFMAFVGLYFADSRAATKGWAPRWYGSYRFLLTAMVGTAIFISLIGRAKIKQGDAITAQGLSNNFSRSGIADHETNWEKLEAEEKERLRKKKEEEEKKAKEAEKKKKEEEKKKGKKGGDKKKSDDKAKASEEGSDKKGEDKDEGKKSDSKADEKKSESKDEDKKAESNDKKEDSKDEGKDEKPKEESSDKQKDESENKDSEEDSGKKDDSKSEEKKDDKSEDKKGDSKDKKDESKDEKDDSKKDESKDKKNKKDDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I1S1F4</accession>
    <accession>A0A098DAL0</accession>
    <name>I1S1F4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG10555.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T08401</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF76003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319553.1">
        <property type="nucleotide sequence ID" value="XM_011321251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S1F4"/>
    <dbReference type="EnsemblFungi" id="CEF76003">
        <property type="protein sequence ID" value="CEF76003"/>
        <property type="gene ID" value="FGRRES_10555"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10555"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08401"/>
    <dbReference type="eggNOG" id="ENOG502SP3K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081631_2_0_1"/>
    <dbReference type="InParanoid" id="I1S1F4"/>
    <dbReference type="OrthoDB" id="3830579at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF76003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="229" mass="25412" checksum="F1AFD67DF29299DA" modified="2012-06-13" version="1">MVIQEVGVMGVKPGIKIMDPTTPEGKILYEAWSTVVTKPGGPSRVYWGLEKDDPLRIWGFFDWDTVEQHEKFAKEHGADAVKDIPKICTYGEMTKHVTMFPSSDVFQSPITDIVVAYFPKDFPHTEKDKAAAKLQDVLAKSFGTYSDVEKIAHGWGIENDFPVKGKKAVDGQPGAALMGFVGWANESAQADFHQTATYNEAVAQIHEMSGLVGLNIVTLRCQHLERLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1S299</accession>
    <name>I1S299_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="10">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Succinyl-CoA synthetase beta chain</fullName>
            <shortName evidence="10">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">FG10885.1</name>
        <name evidence="14" type="ORF">FGRAMPH1_01T20713</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="14">PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
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        <text evidence="9">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.</text>
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        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
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        <text evidence="10 12">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
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        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="43"/>
            <end position="270"/>
        </location>
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            <position position="80"/>
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        <ligand>
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        <ligand>
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        <location>
            <position position="240"/>
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        <ligand>
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        </ligand>
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        <location>
            <position position="254"/>
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        <ligand>
            <name>Mg(2+)</name>
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        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
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        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
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        <location>
            <begin position="362"/>
            <end position="364"/>
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        <ligand>
            <name>substrate</name>
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            <dbReference type="EMBL" id="CEF87727.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
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    <sequence length="445" mass="48357" checksum="3C51A99F32F4FAC8" modified="2012-06-13" version="1">MFKLGRSRAVASALNASKFVAPAARFPGVQQRRALSIHEYLSADLLRQYGIGVPQGSVAKSAKEAKEIAEKIGNDDMVIKAQVLAGGRGKGTFDNGLKGGVRVIYSPHEAEMFAEQMIGHKLVTKQTGAGGRLCNSVYICERKFARREFYLAILMDRQNQCPVIVSSSQGGMDIEAVAKDTPDAINTNYIDINVGVTDETAREIATKLGFSEQCIEDAKDTIQKLYKIFREKDSTQIEINPLSETSDHQVLCMDAKFGFDDNADFRQKEVFEWRDTTQEDPDEVRAAESNLNFIKLDGDIGCLVNGAGLAMATMDIIKLNGGQPANFLDVGGGATPAAIKEAFELITSDPKVTAIFVNIFGGIVRCDAIATGLIKTVESLNLKIPIIARLQGTNVEKAHQLINDSGLKIFSIDDLQTAAEKSVQLSKVVKMARDIDVGVEFTLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I1S2H8</accession>
    <accession>A0A098DXD7</accession>
    <name>I1S2H8_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG10972.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T20919</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325400.1">
        <property type="nucleotide sequence ID" value="XM_011327098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S2H8"/>
    <dbReference type="EnsemblFungi" id="CEF86024">
        <property type="protein sequence ID" value="CEF86024"/>
        <property type="gene ID" value="FGRRES_10972"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_10972"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G20919"/>
    <dbReference type="eggNOG" id="ENOG502RKPZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_700275_0_0_1"/>
    <dbReference type="InParanoid" id="I1S2H8"/>
    <dbReference type="OrthoDB" id="5106681at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010124677" evidence="1">
        <location>
            <begin position="22"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF86024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="376" mass="39556" checksum="0BE1776EAC1F94CA" modified="2012-06-13" version="1">MIVNTFVTAFLAASLMVGSRASPCKVSSRTIDTSTTVGVTSTFAEVPGTTESVASTTGVSSFEDTTLTISQSETSTEASAISEDITTAVLTTDLNPIAIETGTESSTVPEDIITTSVLTTDMNYITIETGTESTISERFITTAISTTDLSSTIIDGSTETSTISDDATTTAASTTDLSSSIVDTSSETSTVPEDITTTAIPTTSAESITVVKETTTTTSEATVFTGFLVNSGFDDTDTVQPWGHSPRTFTSFSIDSNTKHNGRHSARLTSSRLGNFGIGQELAAPVQVGVNYLGTAWIRPGTGCDTASLACVYGDGFAAVAKYFTVFPPNQWTQISFTCVYKQNHVDRGHLGLFLGFDCLTSSSTSWVDTVTFDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I1S3D3</accession>
    <accession>A0A098E415</accession>
    <name>I1S3D3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG11311.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T21753</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF88865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325933.1">
        <property type="nucleotide sequence ID" value="XM_011327631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S3D3"/>
    <dbReference type="SMR" id="I1S3D3"/>
    <dbReference type="EnsemblFungi" id="CEF88865">
        <property type="protein sequence ID" value="CEF88865"/>
        <property type="gene ID" value="FGRRES_11311"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11311"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21753"/>
    <dbReference type="eggNOG" id="ENOG502T08M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062065_0_0_1"/>
    <dbReference type="InParanoid" id="I1S3D3"/>
    <dbReference type="OrthoDB" id="2830113at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF88865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF88865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="280" mass="31784" checksum="C24DEF93547DED90" modified="2012-06-13" version="1">MSHLLWRSEIVHSFEAILSASCEEQWDRLESSVQSTVAVNNTPLQRETFIANLRSDVGNNNISSKLDSSVVDVNAQAIAARVIKTESSSSEESSATQSVQYQEIVLAWFTDGRLSAIKSLQDNDARRARQNSAMGTPARLLENPIPATVDLDSTYRQYIGSINEKTMEATFETFCKPSVTHNTHKKTIAEYIYLIQESQEAIQGLYFDIQDLIVDKDTGRVAARLEFTGVPVKTWTDAEPNGQSVKFHEHVMYWFEQGRIHWVWSIVDLDTYREQCRVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1S3Q7</accession>
    <accession>A0A098E0N9</accession>
    <name>I1S3Q7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG11451.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T22099</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF87671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325768.1">
        <property type="nucleotide sequence ID" value="XM_011327466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S3Q7"/>
    <dbReference type="STRING" id="229533.I1S3Q7"/>
    <dbReference type="EnsemblFungi" id="CEF87671">
        <property type="protein sequence ID" value="CEF87671"/>
        <property type="gene ID" value="FGRRES_11451"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11451"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22099"/>
    <dbReference type="eggNOG" id="ENOG502RYAY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010112_0_0_1"/>
    <dbReference type="InParanoid" id="I1S3Q7"/>
    <dbReference type="OrthoDB" id="5429634at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
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    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CEF87671.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblFungi" id="CEF87671"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <accession>I1S457</accession>
    <accession>A0A098DG60</accession>
    <name>I1S457_GIBZE</name>
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            <fullName evidence="3">Chromosome 2, complete genome</fullName>
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        <name evidence="3" type="ORF">FGRAMPH1_01T11289</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011323038.1">
        <property type="nucleotide sequence ID" value="XM_011324736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S457"/>
    <dbReference type="EnsemblFungi" id="CEF77447">
        <property type="protein sequence ID" value="CEF77447"/>
        <property type="gene ID" value="FGRRES_11618"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_11618"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11289"/>
    <dbReference type="eggNOG" id="ENOG502QR0G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047601_0_0_1"/>
    <dbReference type="InParanoid" id="I1S457"/>
    <dbReference type="OrthoDB" id="10248513at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000039">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.13, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="227"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF77447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="382" mass="42819" checksum="8C0A49C166804DE9" modified="2012-06-13" version="1">MDSISAEPSMDLPVIDLDVYLNNPVDSEAVQEECRKAASALITYGALVLHDSRVSEKDNSTFLDILEDYFAQPVEILKKDEKPELSYQVGVTLENTEKPKCAVDEPCLDVIQRLDPSQRPLDITAHSPDPKCRFFWRMGEQPPFETEFPGLNAANVVPEAPHIKDRWEPAMNQWGTSMKSAVSKLAEMTAVGLDLPAQFFSDAGKYGPHLLAPTASDLTKYGQKDTILAGFHTDLNFLTIHGRSRYPGLHIWARNTGNRIAVKIPPGNYLLVQAGKQLEHITGGLIKAGFHEVIVNDKTIETIEKRKREFPDRPLVRISSTLFWHLGSDVDLTPVPKLAARVKEVRERQKELGRDEGREVEYPPMKVGHQVQAELKHIALMT</sequence>
</entry>
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    <accession>I1S5D9</accession>
    <accession>A0A098D5K6</accession>
    <name>I1S5D9_GIBZE</name>
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        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
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        <name evidence="5" type="primary">FG02005.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T04843</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011317873.1">
        <property type="nucleotide sequence ID" value="XM_011319571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S5D9"/>
    <dbReference type="EnsemblFungi" id="CEF74228">
        <property type="protein sequence ID" value="CEF74228"/>
        <property type="gene ID" value="FGRRES_12057"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12057"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G04843"/>
    <dbReference type="eggNOG" id="ENOG502R9UF">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_440778_0_0_1"/>
    <dbReference type="InParanoid" id="I1S5D9"/>
    <dbReference type="OrthoDB" id="4868114at2759"/>
    <dbReference type="PHI-base" id="PHI:1428"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="46"/>
            <end position="75"/>
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            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="521"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF74228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="653" mass="72714" checksum="1C7D144D8479E421" modified="2012-06-13" version="1">MEPMEDTYDPPEGYTSFDCPNYPENQTLTCPYIGCDGFYNWHRGPYVCGECGHRFAAAPALNRHGRASGHQVEWECYDDECEKFGEKFATGALYLEHLRESSGHRSGEVSDETKNTESSFSPPSNSNAQDTEDDVFGPAPQTATSDRNICNEPCCYHYGTDYKCKSESIRHEDTDAHQIATRLNQALLTNTPADEVKAEQEAIRALRCNWSDCLLFGKTFKNARVFYRHLQEKDHRDGWDIKFQEDSFEYSSDNEPLPGMAFNVDGRKGMCINEKCPRVGMKFDSFTAMKQHSRSFGHALTEEDLASTDVEESGDEIWKTTDVHGMEATQDEGLWKCIKQGCKGYQKIMSNMANVRMHFNSAAHMNAAEEVSSSDDSHEELDGMQFSKDSGWLCVKPGCKKRGTTYRFLYNAKRHFSADIHAMAEEESSHGESREELDGMAYSEETAAWVCAKNTCRSYGKSFVTVGFARKHARCTTHLKADEITPTPRRFKHSSTNSLLTPIEMGGSTANVTPGSPSTGRGLTLVRRPASTSENTPTNRTPGKIRIRRSSGAKSGNGKRITDLERENQELKERVTKLEGEVYGPKSPGVLQSPSAGLLAPPAAQVSKASSSALSSPASSGQMENLAQYVQEEFHLAVSMEVDDDDVWNQAMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I1S5X0</accession>
    <accession>A0A098DKR5</accession>
    <name>I1S5X0_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
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    </protein>
    <gene>
        <name evidence="3" type="primary">FG04508.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T15473</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011321083.1">
        <property type="nucleotide sequence ID" value="XM_011322781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S5X0"/>
    <dbReference type="STRING" id="229533.I1S5X0"/>
    <dbReference type="EnsemblFungi" id="CEF79538">
        <property type="protein sequence ID" value="CEF79538"/>
        <property type="gene ID" value="FGRRES_12241"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12241"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G15473"/>
    <dbReference type="eggNOG" id="ENOG502QUCG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053355_0_0_1"/>
    <dbReference type="InParanoid" id="I1S5X0"/>
    <dbReference type="OrthoDB" id="2922289at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788:SF2">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF79538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="404" mass="46818" checksum="1A100E52A4ED10E6" modified="2012-06-13" version="1">MALLHRKAWLLSVLQIKYKDEGKPIEELPEEYRVALNTFRFFLRKAINDTTKILKQEFECSPPMRWLWGARTDFTEDHKSLLYILEILSLDEEAWTRQSTLVDELERLLKNKPDVDRLISAHVYKSISYLSVLSQCAKQIELYQPWARHYFYQKMFARRYERDYSEEHEAELKSAIEMVKVIRGRQIPLHKLGWTVNPSGGKFKYPYEKRLNKDTVNALRQAEANLDVVWAELDRLTETNKTHYKDLALHSLLSRTLRRTPEWLEPEQTKKKGQPGATDKDLVFLNRPLSNLFLGESEQETPKTAPSGKKKSKAKTKGEPAKAQNIDTPPAEAPEPENVDRQPTFTVDARALKVFRTLFFNPEVTSSPGVIAWNDFSTRHGFDRLPDLEAVRFSVAVPAHFAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I1S6I2</accession>
    <accession>A0A098DI43</accession>
    <name>I1S6I2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T12645</name>
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    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011322393.1">
        <property type="nucleotide sequence ID" value="XM_011324091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1S6I2"/>
    <dbReference type="EnsemblFungi" id="CEF78125">
        <property type="protein sequence ID" value="CEF78125"/>
        <property type="gene ID" value="FGRRES_12453"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_12453"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12645"/>
    <dbReference type="HOGENOM" id="CLU_1875629_0_0_1"/>
    <dbReference type="InParanoid" id="I1S6I2"/>
    <dbReference type="OrthoDB" id="10471815at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF78125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="136" mass="14947" checksum="7090E84DE2EC5BB7" modified="2012-06-13" version="1">MATTAFEVVDHLTVDPLIGLQDTTNTATRVRSPLVVADNHSYLAALLRLLGDLSPVVSLMNPFDLVLTPFRLILDNAILDTTNLWITTTSADKQSRAVNGKRRHSLKDATHSSCFMLSTIVYVEELQLLPSSISII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I1SAC5</accession>
    <accession>A0A098DCE8</accession>
    <name>I1SAC5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T08649</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF76127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319671.1">
        <property type="nucleotide sequence ID" value="XM_011321369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1SAC5"/>
    <dbReference type="STRING" id="229533.I1SAC5"/>
    <dbReference type="EnsemblFungi" id="CEF76127">
        <property type="protein sequence ID" value="CEF76127"/>
        <property type="gene ID" value="FGRRES_13806"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13806"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08649"/>
    <dbReference type="eggNOG" id="ENOG502RYS9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021768_0_0_1"/>
    <dbReference type="InParanoid" id="I1SAC5"/>
    <dbReference type="OrthoDB" id="5404599at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF54">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="75"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF76127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF76127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="310" mass="35375" checksum="9BA0115BE7A62E37" modified="2012-06-13" version="1">MSPFISLDELPQGSSVTFYDSSFFKRGSETITLPTPSEVLARPNFIQHPRAENMKLRIPAVFQELGLAVKHSDSTNTIISEGQCLWAVRRFLPKVPVPEVYGWTQENGIAFLYMEYIDGATLKDRWDSLTVTEKEGVCQELKTNITEISRLRQAPDDEFIGNISRRPLSDMVFTGTNFPPVGPFSSATELHDCMSNMFKWPAKVRQPDIDLADVLDPYRDMLPDDCAIHFTHADLNPVNIMVSKDSPCRVIAIIDWEQSGWYPAYWDFFKVEMTTKPGSEWQTEYLPKLLKEPDPDCCEAFYSYVNSYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I1SAJ4</accession>
    <accession>A0A098DWX3</accession>
    <name>I1SAJ4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 3, complete genome</fullName>
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    </protein>
    <gene>
        <name evidence="8" type="primary">FG11010.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T21005</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="CEF86355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011325359.1">
        <property type="nucleotide sequence ID" value="XM_011327057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1SAJ4"/>
    <dbReference type="EnsemblFungi" id="CEF86355">
        <property type="protein sequence ID" value="CEF86355"/>
        <property type="gene ID" value="FGRRES_13875"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_13875"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21005"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006909_8_1_1"/>
    <dbReference type="InParanoid" id="I1SAJ4"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000023">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF86355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF86355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="533" mass="60733" checksum="DC67085DD9ECD36D" modified="2012-06-13" version="1">MMSRASVAVIGAGPTGITMLKQLLQDGFNATLFERRSQVGGLWAYDAKHGWTSALDSTTANISKYTCGFTDYPIPDRYPVHLTPADFQEFMQGYAEHFGLLKHITFDTSVKVVNRNKEDNGWDVQVENVESGQTDTRHFDKVAFCHGYQTLKKMPIFPGQDHYKGDLMHAQQYRSPESFKDKTVVILGLATTTDDIAPQVVSVAKKVFVSHRSGQIVVRRFRKGTPSDLLVSWRRRVISQWIAKNLPNTYRFLANTLAKLLSSQMAGMKLDPAWRLKDFKDLTLSLPGIIENVLPLLKDGSVTSLHGIKRFTGGKSIEFEDGTIIDDVDSVIFTTGYQCDFSPAPFVEKSIPKLPNYGGPSIHRLYMNVFPPKYADSCVMLCFSAYGKNNGFSFSDVMNMAISNIWRGVSNLPSHQEMEQWVDHHHEWLASNWAREPTVDLSMVKQYEFQPWMHKQAGTGMENLGWGWAGWKFWWKDRKMYNLMNHGVETAHMFRFFETGMRSTWDGARDEIIRQNRIVKEAFGGKKNKTRSD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q4I375</accession>
    <accession>A0A098DCG5</accession>
    <accession>A0A0E0RZG9</accession>
    <accession>A0A1C3YM27</accession>
    <accession>V6RKP0</accession>
    <name>TIM16_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial import inner membrane translocase subunit TIM16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Presequence translocated-associated motor subunit PAM16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PAM16</name>
        <name type="synonym">TIM16</name>
        <name type="ORF">FGRAMPH1_01T09683</name>
        <name type="ORF">FGRRES_08333_M</name>
        <name type="ORF">FGSG_08333</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer with PAM18. Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The J-like region, although related to the J domain does not stimulate ATPase activity of mtHSP70. It nevertheless mediates the heterodimerization with the J domain of PAM18 and is therefore essential for PAM complex function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS231667">
        <property type="protein sequence ID" value="ESU15031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011320456.1">
        <property type="nucleotide sequence ID" value="XM_011322154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4I375"/>
    <dbReference type="SMR" id="Q4I375"/>
    <dbReference type="FunCoup" id="Q4I375">
        <property type="interactions" value="249"/>
    </dbReference>
    <dbReference type="STRING" id="229533.Q4I375"/>
    <dbReference type="EnsemblFungi" id="FGRAMPH1_01T09683">
        <property type="protein sequence ID" value="FGRAMPH1_01T09683-p1"/>
        <property type="gene ID" value="FGRAMPH1_01G09683"/>
    </dbReference>
    <dbReference type="GeneID" id="23555345"/>
    <dbReference type="KEGG" id="fgr:FGSG_08333"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G09683"/>
    <dbReference type="eggNOG" id="KOG3442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101461_0_1_1"/>
    <dbReference type="InParanoid" id="Q4I375"/>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000006">
        <property type="entry name" value="Import inner membrane translocase subunit TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000214093" description="Mitochondrial import inner membrane translocase subunit TIM16">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="J-like">
        <location>
            <begin position="58"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="138" mass="15147" checksum="498917C720858B45" modified="2005-08-16" version="1">MAHKFVVTAFLTGSRILGRSFVAAYKQAQAASAYQRAQVKAGNTTGGASLSSGMTLDEACKILNVKPPAGGQANVEEVLSRYKRLFDANDPQKGGSFYLQSKIVRAKERFEREIGPLREKMEAEAEIKEGFKPKVYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>V6RK40</accession>
    <name>V6RK40_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FG08942.1</name>
        <name evidence="10" type="ORF">FGRAMPH1_01T11243</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011319752.1">
        <property type="nucleotide sequence ID" value="XM_011321450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6RK40"/>
    <dbReference type="STRING" id="229533.V6RK40"/>
    <dbReference type="EnsemblFungi" id="CEF77424">
        <property type="protein sequence ID" value="CEF77424"/>
        <property type="gene ID" value="FGRRES_08942"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_08942"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11243"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_1"/>
    <dbReference type="InParanoid" id="V6RK40"/>
    <dbReference type="OrthoDB" id="5363962at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF25">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="13"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CEF77424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="380" mass="40983" checksum="D4E479CD9FE6626F" modified="2014-02-19" version="1">MATDRVKASVLHGEKDLRLEERELPKPSSNEVQVAVQSTGLCGSDLHYYNHFRNGDIIVREPLTLGHESAGTVVAVGSEVTHLKPGDHVALEVGLPCETCELCDEGRYNICRGMKFRSSAKANPHAQGTLQERINHPAKWCHKMPEHVTLDLGALVEPLSVAMHARDRASLPKGSTVLVLGAGAVGLLAAAVAKADQAKTVIIADILKDRLDFATSNGFADASVVVPMERPQTIEDKLAFAQKVAAMVKETQIDGEAIGEVTAVYECTGVETCVQTAIYATKPGGKVMIIGMGTPVLTIPMSAAALREVDIVGVFRYANTYKEIIELLSNPPANMPDVSRLVTQRYSGMDKIEEAFKMAGKVRDEQGNLVIKVVVDFSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>V6RY56</accession>
    <name>V6RY56_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamine synthetase</fullName>
            <ecNumber evidence="3 11">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FGRAMPH1_01T07679</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3 11"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_011320915.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07679"/>
    <dbReference type="eggNOG" id="KOG0683">
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        <property type="term" value="C:nuclear periphery"/>
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        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
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        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
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        <property type="entry name" value="Gln_synt_N_sf"/>
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        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
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        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="24"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="13">
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            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SCB64590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="354" mass="39641" checksum="8D4F51DC3A348CD9" modified="2014-02-19" version="1">MAAPITSRTETLQKYLKLDQKGMIMAEYVWVDAEGGTRSKSRTLPEKDYKPEDLPVWNFDGSSTKQAPGENSDVYLRPCAVYPDPFRGSPNIIVLAECYDSDGTPNKYNFRHDCVKVMKTYADEEPWFGLEQEYTLLGSDDRPYGWPAGGFPAPQGEYYCGVGTGKVVQRDIVEAHYKACLYAGIQISGTNAEVMPAQWEYQVGPCTGIEMGDQLWVSRFFLHRVAEEFGAKVSLHPKPIAGDWNGAGLHSNFSTKAMREEGGMKVIEEALKKLEPHHVECIAEYGEDNDLRLTGRHETGSIDSFSWGVANRGTSIRVPRETAAKGYGYFEDRRPASNADPYRVTKVLLQFSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098D212</accession>
    <accession>A0A0E0RNZ8</accession>
    <name>A0A098D212_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T02343</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098D212"/>
    <dbReference type="EnsemblFungi" id="CEF72973">
        <property type="protein sequence ID" value="CEF72973"/>
        <property type="gene ID" value="FGRRES_15102"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02343"/>
    <dbReference type="InParanoid" id="A0A098D212"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010018598" evidence="1">
        <location>
            <begin position="17"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF72973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="65" mass="7348" checksum="691D09BE362610BC" modified="2015-01-07" version="1">MFVAIVAILQINVTYANPARPITLHHLSLNHRNYLVLMYFIKASAVDKIVGPRPREPGIKIPKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DB32</accession>
    <accession>A0A0E0RWP5</accession>
    <name>A0A098DB32_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T07733</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF75670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DB32"/>
    <dbReference type="EnsemblFungi" id="CEF75670">
        <property type="protein sequence ID" value="CEF75670"/>
        <property type="gene ID" value="FGRRES_15590"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07733"/>
    <dbReference type="InParanoid" id="A0A098DB32"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF75670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF75670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="63" mass="7465" checksum="7779CD232F82B338" modified="2015-01-07" version="1">MKIKLSHNWRKGFGKLENNWFIHSFAMGDWASMPLQCNSDRLYFVFALPYNVFESRALQTSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DFA1</accession>
    <accession>A0A0E0S273</accession>
    <name>A0A098DFA1_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T11589</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DFA1"/>
    <dbReference type="EnsemblFungi" id="CEF77598">
        <property type="protein sequence ID" value="CEF77598"/>
        <property type="gene ID" value="FGRRES_15163_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G11589"/>
    <dbReference type="InParanoid" id="A0A098DFA1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF77598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="42" mass="4748" checksum="27BDE162BB7413A2" modified="2015-01-07" version="1">MPHRGTLDCIPQILPSANVGMKMFQDDDINYRTKLAKNDENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DH81</accession>
    <accession>A0A0E0S453</accession>
    <name>A0A098DH81_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T12951</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DH81"/>
    <dbReference type="EnsemblFungi" id="CEF78278">
        <property type="protein sequence ID" value="CEF78278"/>
        <property type="gene ID" value="FGRRES_15188_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12951"/>
    <dbReference type="InParanoid" id="A0A098DH81"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF78278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="73" mass="8396" checksum="AFE373F4F6335356" modified="2015-01-07" version="1">MWSFFDVGYDFRKSTGQGVIAGLYYSRASLSFTFTLVLIYALQKTDHIEEHFRICPEVTDHSCDETSMDICSD</sequence>
</entry>
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    <accession>A0A098DHA8</accession>
    <accession>A0A0E0S2U7</accession>
    <name>A0A098DHA8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG03089.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T12037</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF77822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DHA8"/>
    <dbReference type="EnsemblFungi" id="CEF77822">
        <property type="protein sequence ID" value="CEF77822"/>
        <property type="gene ID" value="FGRRES_16333"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12037"/>
    <dbReference type="eggNOG" id="ENOG502RS7C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DHA8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057230">
        <property type="entry name" value="DUF7908"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25485">
        <property type="entry name" value="DUF7908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010018671" evidence="2">
        <location>
            <begin position="21"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7908" evidence="3">
        <location>
            <begin position="111"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="636"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF77822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF77822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="887" mass="95248" checksum="6089A538BE7503D9" modified="2015-01-07" version="1">MKRQIAAFALLSSIANTVTASAKLGDVTYGNQEPGTYCITYLFTYLAPISMGTELPEPSQNSTEPEQTTSSDADEPGRFSTDIEPSLVTTLSPQEPSSVPASQSTSVDFDPTGQRIIFAVTPAEGTRKRDIGGFVGDDICTFATVFTLGNGRLFEGGVPISYLGDAFQLLQSSSLPSGDDITTTFSNNGGSLSFINPGLPGSQASFCQTSSDGAVYMTFTSRPQGCVPVRLTIYGVERCINGRIDGLDTSTAAATQEESTQAAVLPSTEDPLPTSLLPPDMTDEETVFPTLTIDPTRPLSFSNFTSQQSTVKVPSFTSGIVLPSLSPSRSDEPTVVETETLAPTFATTSEEVKSSFEADTTELSSTAALPVLESTSSEGEFPTSSSPASTTDEVSFSSSTLPLPTESSSLTETSDVSNIITTSFESTTEVPTTTISMETTTTEDIIIITNAIANGRFAMPNLNSVGDIMGFQREGLAEYRDGNCYKGDEGTDDGCVVLKTADGRKRNADSFSGISQMLTSLSPSRTVLYTLQFYYVVIEVGPSQACTIDAYLGTLQAFSQTLSIGDGEATSWKRALTAVRADAESASLSISISCSGRGVTMVYVDSVFFSNKVTPDNIDTHRLEFRDAEVPPQQSTVENTPTTVSQTTTASATPTEICKYTHGEECQFDSQKNVPDALCAFEGFFTGDTWKESRTDYPHQDNREQCIAICKSLPDCQASGHFQNENRCLFTTTVITENDFIIYDEGEFWKQASWADQRCWTCPDCIDESVPNMPAEKCSYTQGDVCTRHATPASIVCNTAGWMSGGYISGEYFVDQYPHQESPEACAAICRALFSCKGSSFYGGICLFSTTVLSTTDGPFPLVLDRDPSWNSVWDDSGCFVCPGCTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DJC6</accession>
    <accession>A0A0E0S6B4</accession>
    <name>A0A098DJC6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FGRAMPH1_01T14471</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF79039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DJC6"/>
    <dbReference type="EnsemblFungi" id="CEF79039">
        <property type="protein sequence ID" value="CEF79039"/>
        <property type="gene ID" value="FGRRES_15225"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14471"/>
    <dbReference type="InParanoid" id="A0A098DJC6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF79039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF79039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="63" mass="7370" checksum="1ECD6AA02D9F9C28" modified="2015-01-07" version="1">MRTIADKKERKTKIEGFVIKVVFNLVGWRLRRQKKALLFLWVKSKIESKGSSPLRFISPQPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DJG8</accession>
    <accession>A0A0E0S522</accession>
    <name>A0A098DJG8_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FG03739.1</name>
        <name evidence="1" type="ORF">FGRAMPH1_01T13587</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="CEF78597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DJG8"/>
    <dbReference type="FunCoup" id="A0A098DJG8">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CEF78597">
        <property type="protein sequence ID" value="CEF78597"/>
        <property type="gene ID" value="FGRRES_03739_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G13587"/>
    <dbReference type="eggNOG" id="ENOG502RC91">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DJG8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF78597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF78597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="520" mass="57391" checksum="0213AF5DC39EB7D4" modified="2015-01-07" version="1">MAEHKLPKIRPLGKLEEIAAAAHHIDFFTNCAFSAHYKASQPLTDVDLKPLVFTALSQVLHQHPILFAIPVVPDTEQPYWGRLPSIDLNQVVSFVERSSPLSSDSQTDVELDSLLEDRHNTSFKAGYGTLPVWRLIILQDYHSKDGFVASFVYHHSMADGGSSQIFQDAFQRALCDISSGSVELQVVEVVTSDDRPISSPLEDLHPLPLPENPPVLDAANLNEWRGSTVSVPSKTKYKSLSLAPEVLQSFAQECKKNKTTVTAALPALVAKVLYDILPSETEGLTCNLPVSLRSDLPPNQVDDVIGNFIDAFKVQLLRSDLDQSSEGTTAIWKHAKKVQQATRRYFANASPSGEPYANVAIFKLIPDIKAFLSSTIGNPRGESFEVSNLGHFPEPKNLKGNGNPPWRRGKLLLSRCAFAPGAPLIICVIDNEASILCMGLLTNPPTVTYITRTMKLDQPVNFVIVFARSEIPNLVIDTSVNSEAIHLLLILSHSSKHNDYHCLPYFQLNCYQLGSETLFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DN79</accession>
    <accession>A0A0E0SA68</accession>
    <name>A0A098DN79_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">FG09233.1</name>
        <name evidence="16" type="ORF">FGRAMPH1_01T27609</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="16">PH-1</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="protein sequence ID" value="CEF83331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="229533.A0A098DN79"/>
    <dbReference type="EnsemblFungi" id="CEF83331">
        <property type="protein sequence ID" value="CEF83331"/>
        <property type="gene ID" value="FGRRES_09233_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G27609"/>
    <dbReference type="eggNOG" id="KOG2068">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A098DN79"/>
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        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:positive regulation of RNA metabolic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:protein ubiquitination"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="mRING-HC-C4C4_CNOT4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CCR4-NOT core complex subunit Not4"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 12" id="KW-0694">RNA-binding</keyword>
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    <keyword evidence="5" id="KW-0862">Zinc</keyword>
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        </location>
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</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DRV4</accession>
    <accession>A0A0E0SDT2</accession>
    <name>A0A098DRV4_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T26797</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DRV4"/>
    <dbReference type="STRING" id="229533.A0A098DRV4"/>
    <dbReference type="EnsemblFungi" id="CEF84595">
        <property type="protein sequence ID" value="CEF84595"/>
        <property type="gene ID" value="FGRRES_17592"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G26797"/>
    <dbReference type="eggNOG" id="ENOG502SNDG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A098DRV4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010018729" evidence="2">
        <location>
            <begin position="22"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF84595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="869" mass="90558" checksum="283385FE235D0DC7" modified="2015-01-07" version="1">MRVVQVTALLSVATLVPSTAGIALPRFDSGQQSPRRFPHNDTAIATAPDGSTTRLSPLIQAPQATTSSQEDGFVSLSSQTSPVESLEVVILETTSNSWSEAVGLPLTTTELGNDSTTSSSLAQYTSARTVLSLTTEQLDHDLTNSSTSAGVTLSTQQPLKPLSFSQVVSGFTTATHGTALPSSSDWDRDKDAISVETQDTINASIQRRPNQGFARPLTTTAPNNTKPQSQTCGSGSKIPCAWIPSPSASSRRWNGTHTPGPWTSGTLTVITPTSVSCTTLQADEPVTEYSIVYTSTVTFFGNISEYTAPYPTITTPNFCQTEPVGATLSSNVGGPLPSSTTLSPKEPPKKCMTGEFCPTDKIPEFSNPTIFPAPDVPGQTFTSMRPTVTFITTDKNPAVVFTTKSPPRFDMPTDGGGLPMSNKKEPAPTKELRPNRVQSSKDHGKAASQPQPTSGDQSHGQPQRHPLPGFEPGSGSSPDAGSESDPKPGSGSSSGSNSGPNNNSDPEYSSRSGSDSNSDLGPNSEPKLMPIAVQTKTFVVTARDQEVIVNDKTFSGLKVDQTTTVTVDHGTFTIRPTEVAGEGVTIKKPQPAGTVVSVVSPTSAILGQVPVAVSGTEASFGGTTVRIPLMGTTMRLEIPTQGSNTLVDEREVFIAPDRIVVDGETLKYHGVGAPQTDVIIEGGEIVTAVGQSVLVFRSTTLTYGPSIPGITETIDDDIVTIGPAGVVVDGTTLGGPEAKAGDTKRQIVGGATITKVNPSYIIVDETTFTAGPGAKSTTKEAGGETITIGPQGIIIGTLTIRYPFGVSTVTTIEAKETGSAMLPAATGTNNNNAKVDSKDDDDSGAAFLRSGLTMEMTGLCIAVGVWIMV</sequence>
</entry>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="1">PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF84667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DTI7"/>
    <dbReference type="EnsemblFungi" id="CEF84667">
        <property type="protein sequence ID" value="CEF84667"/>
        <property type="gene ID" value="FGRRES_15363"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G22407"/>
    <dbReference type="InParanoid" id="A0A098DTI7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CEF84667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblFungi" id="CEF84667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="63" mass="6831" checksum="D8925DE4D1AA4E7C" modified="2015-01-07" version="1">MRKVICVCNFGGNNIILATKTEVDPVTMGMVHTGQPMKGILLIGKDSITYSAHNISLLLQSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2023-09-13" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A098DUU5</accession>
    <accession>A0A0E0SGR2</accession>
    <name>A0A098DUU5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
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    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T23133</name>
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    <organism evidence="2 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DUU5"/>
    <dbReference type="EnsemblFungi" id="CEF85625">
        <property type="protein sequence ID" value="CEF85625"/>
        <property type="gene ID" value="FGRRES_15386"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23133"/>
    <dbReference type="InParanoid" id="A0A098DUU5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF85625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="63" mass="7066" checksum="AE2F667EE4B86E67" modified="2015-01-07" version="1">MSQGYAFQRKLPIQGEGISRCWEEYALGLRLADLPTSFRVHGTTKNNPRNKSKGWIPSSLSAD</sequence>
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    <accession>A0A0E0SFV9</accession>
    <name>A0A098DVC8_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
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        <name evidence="3" type="primary">FG06808.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T23233</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF85322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A098DVC8"/>
    <dbReference type="EnsemblFungi" id="CEF85322">
        <property type="protein sequence ID" value="CEF85322"/>
        <property type="gene ID" value="FGRRES_12991_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G23233"/>
    <dbReference type="InParanoid" id="A0A098DVC8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF85322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF85322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="344" mass="39702" checksum="EC022E3EEADFA068" modified="2015-01-07" version="1">MAPNLEGLPIETVQQVASFLSHKDIRNLSLSCRSLRSKLYRLLWSRVLIHGGENDLARTLKTFDIESEHGRAILAFIKKATIHKDMVRPFWHADTWDALKYDVDPIFSTPIPQAIMQTLQAMTSLESLHLNILAFSAQQELAFLDLLQATPDIKLQNLTIRAVCKVAKSFIPKCSHDLRSLDTYDCKMSTGIFKSKKLEKLRIQSQYTAMLGLHHHQSVFILGDLMEMPSLRNISNRFPALKTLILHETSRYNVDPATADPKRFGHLERLAFNLNWIEFYNIVFDENFFHDLVTRIAREHRSLQEVCVLFGPPRFDHWKRDRGVTLRNFCEVPNPMGFPFGVED</sequence>
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        <submittedName>
            <fullName evidence="10">Chromosome 4, complete genome</fullName>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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    </reference>
    <reference evidence="10 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        <citation type="submission" date="2017-01" db="UniProtKB">
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                <consortium name="EnsemblFungi"/>
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        </citation>
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            <strain evidence="11">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
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    </evidence>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
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                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
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                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
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                <person name="Park J."/>
                <person name="Park S.Y."/>
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                <person name="Turgeon B.G."/>
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                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
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                <consortium name="EnsemblFungi"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF87399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF87399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="97" mass="11019" checksum="B83B5F5A9637A863" modified="2015-01-07" version="1">MGMDAFEHPYRDTSSSCEVDGNMRDNRNVNMDGGHKRNMDRSDTTLMNFMHASHAYILVDDRETQGRDRVMLGGKITCLQGVGLLTSRKHTTNMLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RPZ6</accession>
    <name>A0A0E0RPZ6_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T03039</name>
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    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RPZ6"/>
    <dbReference type="EnsemblFungi" id="CEF73321">
        <property type="protein sequence ID" value="CEF73321"/>
        <property type="gene ID" value="FGRRES_20031"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03039"/>
    <dbReference type="InParanoid" id="A0A0E0RPZ6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF73321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="83" mass="9524" checksum="F2760E17617FE0AC" modified="2016-04-13" version="1">MSNSKLQRPDMVLIRKLYPYLCEDKRRRTLSFDRVTDRTKSIFIRIKPSMVKGSPSISKFTTSTKIFQPGSSPRNANPSLSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RRA7</accession>
    <name>A0A0E0RRA7_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FGRAMPH1_01T03951</name>
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    <organism evidence="10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="9">PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF73782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RRA7"/>
    <dbReference type="EnsemblFungi" id="CEF73782">
        <property type="protein sequence ID" value="CEF73782"/>
        <property type="gene ID" value="FGRRES_15865_M"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G03951"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0RRA7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF48">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="66"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CEF73782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblFungi" id="CEF73782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="514" mass="56815" checksum="C46398CB725E5AD2" modified="2016-04-13" version="1">MATSSDRDQEKGFDERSEMKDISGVGNTVHDAAGHGHAATDAYGNALVQFDPAAERRLRWKLDLYTVPTVAVLYLFCFIDRANIGNARIAGMGADLNLQGYDYNKILSVFYISYIIFEIPATVTCKWMGPGWFLPLTSLLFGIVSVATAFCKTQGALCGVRFLLGIFEAGMLPGIAYYLSRWYKRSELTFRLSLYMVMAPLAGAFGGLLASAILKLNHFGSLHTWRMIFAIEGVITIGLSLLAFVTLTDRPETARWLTQEEKELCIARVKSERLAQTEVVDGIDRIKLWRGVSNPITLQIACIFLCNNITVQGLAFFLPTIVGTIYPDYSVVQKQLHSVPPYAVGAVFAVVFPAISWWVDKRQIFIIMSAPTVIIGYAMFLGSETAGVRYGACFLIASTCMVLGTMTNAHISANVVSDTARSSAIGLNVMFGNIGGLIATWSYLDKDKPNYPIGNSINCAAGCLIFLISISGYLWMKWDNNRRDKKNVEQELAGLSPEEIANLDWKHPGHRWHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0RTK5</accession>
    <name>A0A0E0RTK5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FG02303.1</name>
        <name evidence="3" type="ORF">FGRAMPH1_01T05551</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF74580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0RTK5"/>
    <dbReference type="STRING" id="229533.A0A0E0RTK5"/>
    <dbReference type="EnsemblFungi" id="CEF74580">
        <property type="protein sequence ID" value="CEF74580"/>
        <property type="gene ID" value="FGRRES_15967"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G05551"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0RTK5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04433">
        <property type="entry name" value="AFD_class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CEF74580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblFungi" id="CEF74580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="556" mass="63204" checksum="0003A17A063CC8F8" modified="2016-04-13" version="1">MQTKNINLPEDVLFSRLLKLANEYKDQVIVDDHSHDTQFGYRHVLDGTSKLLQRLRSLHGSTPDQDEDLYVGVLAPNGYEFIISVLAVLAFGGVVVPMPTGALPLEAAYMLEQCNAKYLLASPEHVDLGTRIQAEVEIPLIPIDSQGETDALLPIEAYSLDTSIRVAENRPSILFFTSGTTGAPKGVLHSRKTINKYARMAEAGPNDDICLIPSGAFWSVYFTKVFQMLLTGVRIEIQNFGRNYNLIWEKFRERTATKIVLSPTFWYGMMHYFQENISKLPEDVVKEYIEGAIHLREATATGAMPSRRLKEFWRDLRRGKSLRVLYGSTESQETLICSGEVEFTENDLGTPLPGVEVKLEGSTGELLVKTPSLFLGYLNRQRDTDERFDSEGFFKTGDLVTRHEGRLVFQGRANMDLFKFYTYKVPRMQVEACLTALPYILEGYVLPVADPHCDTRVASLVRLHDNAGKVDLKRIRDDLSDDLPAYQLPTILRILRQDEEVPRTWSDKLAMKKVVQKFFPQDSDDRLYDESTEVMDVSEFMRAKTNKLWDLSGMRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SA25</accession>
    <name>A0A0E0SA25_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FG07277.1</name>
        <name evidence="7" type="ORF">FGRAMPH1_01T24405</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="7">PH-1</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SA25"/>
    <dbReference type="STRING" id="229533.A0A0E0SA25"/>
    <dbReference type="EnsemblFungi" id="CEF83288">
        <property type="protein sequence ID" value="CEF83288"/>
        <property type="gene ID" value="FGRRES_16802"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24405"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0E0SA25"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859">
        <property type="entry name" value="ACYL-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859:SF4">
        <property type="entry name" value="BUTANOATE--COA LIGASE AAE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="34"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="497"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CEF83288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="588" mass="64798" checksum="1AA2E0C5DCB8F00D" modified="2016-04-13" version="1">MSDPPSRIRSILSHLRPHPAAPVNYHTLSPTTFLERAAAIEPDAEAIFHITVNGAVLRRSYAEFADRARGLAYYLLKHGYRRVGVLAPNTPAFLESIYGIVAAGAVIVPANYRLKQEDIAYIFDFAEVDCIIVDNEFVGLLDAYKEKHENVPLIVDMVDFLPHEQAEACFKAVANLAYQDNDATVGQLSGPFDDAVLEGLKHDIAQGSQGWAGLHSQARSEDDMLAIPFTSGTTSKPKGVVYTHRGSYLAAMANIVESGLNIGRCKYLWTLPMFHAVGWTFPWAVVAVRGTNVCLRKIDYPLIWKLLKEEGITHFNAAPTVNTLLVAAKEAEKLPHEVKVTVAASPPTGYLFEQMTKLNLIPVHVYGMTETYGPSTKCYTLPEWDSLPPTEKYAKMSRQGHGFITSLPIRIIKPDQPQGVLIDVAKDGKEIGEIVFMGNICAKEYYKDPAATRELFAGGVLHSGDLAVWHPDGSAQIQDRAKDIIISGGENISSVALESMLAQHPDILEAGAVAVPDSHWGERPKVYVTVKDGKSVTGDEIIQWAKHQSDISRFMVPREVEIVDELPKTSTGKIKKNVLREWAKHGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0E0SC27</accession>
    <name>A0A0E0SC27_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FG07215.1</name>
        <name evidence="2" type="ORF">FGRAMPH1_01T24249</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="CEF83990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0E0SC27"/>
    <dbReference type="EnsemblFungi" id="CEF83990">
        <property type="protein sequence ID" value="CEF83990"/>
        <property type="gene ID" value="FGRRES_20358"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24249"/>
    <dbReference type="InParanoid" id="A0A0E0SC27"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF83990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF83990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="135" mass="15287" checksum="5F847B8162E040AF" modified="2016-04-13" version="1">MEVITFFVILSVAIAFIANDPIQTPFGAIFASFFVAFFALIGGASFINHVIISVQERLVVPPEDDIFSRPSLRRVTGYGPAEFDTHDKFYHTYGICCGKRGHCHSCLKQHAERLRDEQVEDKFEFDRTIKQALAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YHP3</accession>
    <name>A0A1C3YHP3_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FGRAMPH1_01T01897</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
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            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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    </evidence>
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    </evidence>
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<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YHY1</accession>
    <name>A0A1C3YHY1_GIBZE</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
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            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A1C3YHY1"/>
    <dbReference type="STRING" id="229533.A0A1C3YHY1"/>
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    <dbReference type="eggNOG" id="ENOG502T5Q1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YHY1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="611" mass="70113" checksum="90D41C8A4C778CE4" modified="2016-11-02" version="1">MDKGGASAAFWPRDLSQIGQENPRVPTLEGLEYEAIFDKFFDYELYSDSTQTQEHLAASSPFRSTHRESSPFITDIPYFFDHLSLGRDEAGYPNMTPGLNLDDGITTSESMGQTPPGLVRGDSTSPSSPSSPSGSFSLDGVDDPRRRPRHSLREVRAQDDEWTYPQAVSSKHAPKAYGYPPQVQVHESSSRRSSHSSKTYSPPSTSGVKRQRSVEKRSRHLSDPDQTADVRKSGACMPCRISKTRCQDCGVCPFCRKAFPDHSHLVCTRRTPAVAPPVIRRIADVWSPDPTEERRVVDNEPRFPTAKPKDILIYFTRDAESPYLRASVQAYHSKYGVDESPRNAAFERDRFPSYIELQRWVEAQIRRERSSRFEHLVQNFLLSYYEEGQGLPKHNLVSKVHTMNCFFRIWKAPRFTCCSSSNKISQVPFTVQAELRRIAWNALVSHEHDILKLLEDVLAQQDSLKAQEKMAVWASLWQLLLMYRDLIIAHDGYFSRNPGAQQDQNTVGAFENLYNSFFPLIAMFYHCQFKTPKRMEMSMDWLKDYPSHARHSAKLRQVSQDMMDAKKEFYERVQRSSHKVDERLCVFVVDHEMKKISTKRRPRSSTKSKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YIC4</accession>
    <name>A0A1C3YIC4_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T02953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YIC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G02953"/>
    <dbReference type="InParanoid" id="A0A1C3YIC4"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="171" mass="17961" checksum="3D6AA02FA85808EA" modified="2016-11-02" version="1">MRSHLSGLEMGGWVPGTPDRTLPYLLHGLSLQQPPGDAPHLTTHGATSDGGGRGTAGNKTGSVQFSVVSKWVSRTSTVQSTYCKLTRAANDGWNFKGAPVEKTKVGPSSNGDGTGTWVEGMCEKPSRTMGGASSFIKVQADQSEHCLSRSPQVITTTSTVVVRQPASPTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJ85</accession>
    <name>A0A1C3YJ85_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T08357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJ85"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G08357"/>
    <dbReference type="eggNOG" id="KOG2317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJ85"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF42">
        <property type="entry name" value="MMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="136" mass="14605" checksum="7B11B43B2ACF3CF2" modified="2016-11-02" version="1">MMALRTGILTTDAPAPSPHLSQAIIHNGTVYCSGSFGMDPQTRELADGPYHQTAGALRNLDSILKAAGTTLHNALKVTIFILNMDHYAEVNKAYLEFFTSDPKPSRTCVAVAQLPLKGAHVEMEAIAAIPEKSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJB1</accession>
    <name>A0A1C3YJB1_GIBZE</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 1, complete genome</fullName>
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    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T07631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJB1"/>
    <dbReference type="STRING" id="229533.A0A1C3YJB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G07631"/>
    <dbReference type="eggNOG" id="ENOG502QVZ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJB1"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38120">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38120:SF1">
        <property type="entry name" value="M PROTEIN, SEROTYPE 2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
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            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="232"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="63"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="200"/>
            <end position="211"/>
        </location>
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            <begin position="333"/>
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        </location>
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            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
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        <location>
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            <end position="489"/>
        </location>
    </feature>
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            <end position="526"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="545"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB64582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="628" mass="68611" checksum="8F4E979285153B61" modified="2016-11-02" version="1">MSAATKKPPAGGVGRVSQADSSSSASPSPPRPGSRSTTPTSNGHSRTRSLRTNAPVSARAAIARRDTLSASDSDARAEAAAAVEDLQKRLENEEKSSLQYKRQAEVLQSKLDEAVKESAKLEEKAHEYEEQIETLSNEKREVTRQMREMESIYESERSSILKEKEEMANREEEMQAMIQRLKESLAQRNNIVEDPRPSRQHSGNSSPSLENGSFAPPSSIQRSDSRNSSKLILQKDKLIESLRLELAEAQIKLVETENQGGGRLHEVERLLMEARMANARLMEDNESYQLLLQERTLKGDFGQNDFSYMGSNSNQDALAALEGKAQGSSLADELSEATEGESVSDGDRRLESELRSMKEQNKALTLYINKIIERLLQHQDFESILDTSGDLKSLPDTNKELPPAPADNKQQQQQQPSATILQRAKSMAAAAPAKPRPRPISVMQPSTSSDHTDPDKAPSIPIGLSRSTSSRRSPRPQSDQFTGAASLVSQMYRGPDGPVSPPLGTPRHSQTFFSPPNNSGNPNAAARVPSGASVATSGNFPGMRSETSSLSGESGELSMSTPPSQSPPRAHSDRHTTSFAGGKPRPLRLVQENPDAVKENKRASWYSPFTWGAKKEEQQVPSGNPIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJP8</accession>
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        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
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        <name evidence="2" type="ORF">FGRAMPH1_01T16459</name>
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    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G16459"/>
    <dbReference type="eggNOG" id="ENOG502SVX1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJP8"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB64661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="562" mass="62298" checksum="F85066AD6AA423E7" modified="2016-11-02" version="1">MSTTSSVSSTAAASTNASKGLNDGEVAGVAIGCLIAGLIIGTIIGWLIFRSKGQQRYARQRRRSEDRGRLVDHPREANAVPLGISGDPMKLENIILQPTPDQDILSGLRRLEDIIRQHVETVYHLKPVDVEEKALACALADAGYSSSRSGIDIETVAGWCNEIDTRCGALRHVLSNILFSAIDWNNPGPLTLLPESAVAFMSSVRRNEKHRDNVNVMSFAWTRWRTLSALFMHPAPHERTPLDLSEPDIRDQAEALAKALDPVLHYFVAPDDESQHQQVSGVRHTMALNIGLCLSQSLGSSKIIVFHTHLVAADDCNLTKMTEYLGPVGSLTNVTYHVIKLLIKCKQASDEVRRSLELVRTCDRDLQHLISLREEHLDILERKPIELVRVNSIIEDAHNGLLEVGRIVEKCRPEAQKKGLPFCRRGLWVMFDAEEFNSQVPVVNSHHQSVLTEIQFLRLIGIHAPPPIQINKIEAEPNIVQKRRIDIGNVNLLGSLIGVRSVTTSPIPQPQANTADCLPYPSDSDLMPPLPPSYSDASFVATSSTKHINILDIQERWSPYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJS0</accession>
    <name>A0A1C3YJS0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FGRAMPH1_01T17865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJS0"/>
    <dbReference type="SMR" id="A0A1C3YJS0"/>
    <dbReference type="FunCoup" id="A0A1C3YJS0">
        <property type="interactions" value="780"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YJS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G17865"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJS0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12614">
        <property type="entry name" value="RRM1_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12619">
        <property type="entry name" value="RRM2_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000117">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000224">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000134">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated rna-binding pub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF5">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="82"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="172"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="298"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="430"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SCB64752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="473" mass="50940" checksum="82B45FB4D9B3232C" modified="2016-11-02" version="1">MADAGAPSNPGQLPPPQAGAGAPGYEAGQNGQPMAPPPLHIPQNNNPIPTAITSPRSADNGGIMSPTSAGGFRRAAPEPNKRALYIGGLDQRVTEEVLRQIFETTGHVQNVKIIPDKNARGYNYGFVEYDDPGAAERAMQTLNGRRVHQSEIRVNWAYQSNTTNKEDTSNHFHIFVGDLSNEVNDEVLTQAFSAFGSVSEARVMWDMKTGRSRGYGFVAFRDRPEAEKALSSMDGEWLGSRAIRCNWANQKGQPSMAQQQAMQAMGMTPTTPYGHHQFPAHGVASYEVILTQTPSWQTTVYVGNLTPYTTPNDVVPLFQNFGFVVESRFQADRGFAFIKMDSHENAAMAICQMNGYNVNGRPLKCSWGKDKTPNAQGGFDPVQPFSPQSAQAPGFPGTPTGYYPQYGAQYGGQPGNYGGPQAGSPAGYAGSPMGYAAPQSAGGYGRGQQPPNAEWAQPRPGQNFNNGFGGYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YJT9</accession>
    <name>A0A1C3YJT9_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FGRAMPH1_01T18457</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YJT9"/>
    <dbReference type="FunCoup" id="A0A1C3YJT9">
        <property type="interactions" value="507"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YJT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G18457"/>
    <dbReference type="eggNOG" id="KOG3197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YJT9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000011">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="14">
        <location>
            <begin position="135"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SCB64805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="326" mass="37089" checksum="579A618ADB521B64" modified="2016-11-02" version="1">MIVSTVLRPRQTLLFVNTFNSTVNSLRQLPSTRTTTIDSTPRRHIQYRLYSTRKMGSQPEQIKENGHRSSEEVIADLGFTPMVKVDGQWTVDKVVKEIPGGAPAEESSSPLPFFHMLERLKTTKREGWRRFGISRGESIADHMYRMSMISMFAPPSLAPKLDLAKCMKMCLIHDMAELLVGDITPVDGVPKPEKSRRESETMDFLTKNLLRNVAGGTTGEDIRAIWQEYEDSETLDSHFVHDVDKMELLLQMVEYEKRGEGILDLGEFAYVATRMHLPEMKAWGQDVLKEREAFWGSKKHVNGEDGTNGGVTTERKGQQDDYYNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKE2</accession>
    <name>A0A1C3YKE2_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FGRAMPH1_01T21395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB65011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKE2"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21395"/>
    <dbReference type="eggNOG" id="ENOG502SN3P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YKE2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="382"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB65011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="617" mass="71129" checksum="0DAFB6F40420C71A" modified="2016-11-02" version="1">MAIARIRTADEPQSAAWNIDGANYIGWTNRVWEGEAKDDECRDCTTVDRTPADPQILLWESLPCWPEDDDPNDPNWLPGEDSQTDSEPLEYDSGCEESDEAANESDCDRVDHDSVNEEHDGVEDLCPMSELCDQPRPERLPNGTWYNNKIYYTGNRRAPILGDFPGKNAHMVPPEHIASPSCQNLQGINGQRLSVEQMKNCRNVRFLIPKLQNWKLGDDERLMEEDSLFCLSGESNGSNVIEDRYFVPWKSFYPPRHGLRELSCSWQMINEGADGSDALYPLPVHSYCLDIYAKASYRRIGRVDLDGLWHWREIETQLHSDQKPFPNRPVILKARQHWELPWHHYTGDEWPTANPVEIPGMSKILTSCLDVTLCQRATQREASIIGLLPKELLDQIFDLLSPTDVDSVAHTCHKMYQLTQSRFREIVRNDMAWLWEILEESQYPASPERPVAWDPLWPLGIPPPTLPVGLEKEEAEEELWADIIAEYPEMEEVANAVKLTNVKRREEILAPYQEKLGSLSKTWQDFRASVETWICRSRNHTNEVDWGRTWRIFNPKTTLLPGVRNRARIWEDCQQIMDHVELARESGQIDKMYPDLLAKLADSSHPGWSMDPDVDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKE9</accession>
    <name>A0A1C3YKE9_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T21585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB65020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKE9"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21585"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YKE9"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF77">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SCB65020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="272" mass="30634" checksum="592DF96CD780495C" modified="2016-11-02" version="1">MSSTKEAEEVIGIKNEHLAHQERRILQNAKRLLFEVLRFTSGKTFNRASAANETTFMLFKNYPDRIVIECNHDDLRRICAVRSPYVRADWYKGMRLEPDKDVILTYSNDKHTEMRSKMATGYAGKGSENFEKDIDARITELLKLIGNKMAGTDLAATTLRVAILYILTQPQAHMRLLDEFRAHGLLSGRSIETIVSIAAASNMPYLQACIKETLRICPPFCGLLEKVVAHGGDVISDGRILPKGTHIGLSFWGIMRDTDVFGDDADVFRLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKH2</accession>
    <name>A0A1C3YKH2_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FGRAMPH1_01T19907</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB64897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKH2"/>
    <dbReference type="FunCoup" id="A0A1C3YKH2">
        <property type="interactions" value="435"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YKH2"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G19907"/>
    <dbReference type="InParanoid" id="A0A1C3YKH2"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281:SF8">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 12, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000278">
        <property type="entry name" value="Cyt_c_oxidase_6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHCH"/>
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    </dbReference>
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    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SCB64897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="87" mass="10316" checksum="CFBB566A0E29AF22" modified="2016-11-02" version="1">MSDDGQELVTKPFKFVTGTDARFPNMNQTKHCWQNYVDYHKCIIAKGEDFAPCRQFWLSYRSLCPSGWYQRWDEQRESGNFPVKLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YKP7</accession>
    <name>A0A1C3YKP7_GIBZE</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 3, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T21235</name>
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    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970334">
        <property type="protein sequence ID" value="SCB65003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YKP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G21235"/>
    <dbReference type="InParanoid" id="A0A1C3YKP7"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB65003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="87" mass="10245" checksum="73617532E22BDFB9" modified="2016-11-02" version="1">MSFYTFSDFEYGDSIPDDDWEYTVAPPPPTPVPASRQKRGKGCPPPKSRRRLQREAARRLRVLDEMDRLAQFGTACWYCHILRRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YL37</accession>
    <name>A0A1C3YL37_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartokinase</fullName>
            <ecNumber evidence="10">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FGRAMPH1_01T24779</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="10"/>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YL37"/>
    <dbReference type="FunCoup" id="A0A1C3YL37">
        <property type="interactions" value="309"/>
    </dbReference>
    <dbReference type="STRING" id="229533.A0A1C3YL37"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24779"/>
    <dbReference type="eggNOG" id="KOG0456">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YL37"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.10:FF:000001">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000023">
        <property type="entry name" value="Probable aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="12">
        <location>
            <begin position="423"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SCB65262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="486" mass="53344" checksum="4B3A99A4AF2EEDB7" modified="2016-11-02" version="1">MGSLSYNNSPDLGWVVQKFGGTSVGKFPDKIAKDIVRLLAVYVKLRGVGAAICSDEEQQNELVEQARGLMLDICNDHVFAAESFIKDQNLRETLIQTVKDECQELVEYIVAAKRFNLEINSRAKDRVISFGEKLSCRFMTTLLQDVGVESEYVDLCDAFHYDAAGRLDDRFYRTATEAFTRKIAACENRVPVVTGFFGNVPGSLIDGDIGRGYTDLCAALLSVGVKAEELQVWKEVDGIFSADPSKVPTARLLSSITPSEAAELTFYGSEVIHHLTMDQVIRAEPPIPIRIKNVKNPRGNGTIVVPDRMRSASHQLTRGSPTPKAEAEHRKPKRPTAVTIKDHISVINVHSNKRSISHGFFARVFSILNHYSISVDLISTSEVHVSMAIHASSQQVEAFANAAAELADCGDVSILTDMAILSLVGAEMKNMVGIAGRMFSTLGEHNVNLEMISQGASEINISCVISARDATRAMNVLHTHLFTFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YLC0</accession>
    <name>A0A1C3YLC0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome 4, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FGRAMPH1_01T24757</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970335">
        <property type="protein sequence ID" value="SCB65259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YLC0"/>
    <dbReference type="FunCoup" id="A0A1C3YLC0">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G24757"/>
    <dbReference type="eggNOG" id="ENOG502QT02">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YLC0"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF1">
        <property type="entry name" value="SULFITE EFFLUX PUMP SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SCB65259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="287" mass="31948" checksum="59884FFBC29D7DE5" modified="2016-11-02" version="1">MIVFVCVPAWGYKAAHLAWALWWIDIVMAMSCNLYIPHCIMRTEGITLEQTNPTWLFPVIADIVASGTGAIVANVLPNNQHAIWTVVISYILWGTSVPMAVLILAMFYNRLMIHDVLPSQSAVTAFIAIGPLGQGAAAIQLLGKVALKIFERNDFIPMAPIAGQFFYLTGILTALIMWGFAIAWLFFALATIVRREFKFSISWWAFTFPLGVFTVSTTTLAQELPSRFFKVLGTVFSVVETLLWIMVACRTIKATLNGELFQPPPLEAWENKVVETVEDEKVEDSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YME5</accession>
    <name>A0A1C3YME5_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T10433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YME5"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10433"/>
    <dbReference type="InParanoid" id="A0A1C3YME5"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SCB65638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="133" mass="15281" checksum="651D9E74FAE6BD30" modified="2016-11-02" version="1">MVRLEAHRPVIKYGEEKRYYNIKVPYNLSQKELDSHYICLWEVRADEVVGHWSWDELSSKPNWYDDAVLPALKSFREKRQQYQVSEDLSIALSALGLNEPSTESSSDHGSSDEEVLESPNGSDPIRDGIRANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMK3</accession>
    <name>A0A1C3YMK3_GIBZE</name>
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        <submittedName>
            <fullName evidence="10">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FGRAMPH1_01T10939</name>
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    <organism evidence="10 11">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YMK3"/>
    <dbReference type="STRING" id="229533.A0A1C3YMK3"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G10939"/>
    <dbReference type="eggNOG" id="ENOG502SKXY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YMK3"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SCB65673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="688" mass="77830" checksum="A259812420F7628D" modified="2016-11-02" version="1">MVQKKACDACHKRKIQCDLTDSDAPCNWCQHHNLACTFDRVRGRRKQAARSRSKQTSESSLSERLRKVEEALAQTLASQSDPLSRVSKHFTSSSLPVHDHSESPTIENGKEPTPVVVTQPDPSDSSMADSESIVQPESLTTFVPSPSAVSYGQLHFDGCHFGHLSQHNGLPLISDQGKEWIASKTGEQVRFETGRQLRPPLSTPLSTHRFTDPHDLYTLPDRTVVETIWHVFSNSSFRLVFPVVDPELFYDTINLAYMSWSGETPSLEHMSQMACVLAFASMIPLFQGSLVDLPPVDTDICAAKARYILTDVLEGPNLATLQVAFMLNMHEIFLGRLRSASMFHAIACRMAFTLGGQNYTTTETNKGRITHRDRERRQLRLLFWLAYIFDKDIALRSGQPPLMADDYCDLTLPENYLECYEYLPGLSHHLPLELAGNTALVPHLPGDPRLSHIKEKTSRLLYSAQAARKTPAQLLFDIRDLDDELETWRKSIPQNFRPQLSIRNNYQVNVENMHLPRSMRSITLHLEYHHLLTTIHRASGRCMHHPEQEKSNIDAEWPSTIESGVESSIALALEASRSTLLYLMAAMNGLAGEAFWVVVFYPTAAMITIFFNILMHPLRPSAKTDLELLKSSSDLIRKLPSSHLRPHDERMEMINDFCMELVRLASSAINKAVYELDREHEILPPTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMT6</accession>
    <name>A0A1C3YMT6_GIBZE</name>
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        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
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    </protein>
    <gene>
        <name evidence="11" type="ORF">FGRAMPH1_01T12655</name>
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    <organism evidence="11 12">
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        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YMT6"/>
    <dbReference type="STRING" id="229533.A0A1C3YMT6"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G12655"/>
    <dbReference type="eggNOG" id="KOG0496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YMT6"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008687613" description="beta-galactosidase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="10">
        <location>
            <begin position="399"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SCB65799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="1020" mass="113368" checksum="02D0CE80D6B1CA99" modified="2016-11-02" version="1">MKLLSLSTVGLLALTGFSIAQENANVPIQDNGLTNIVQWDDHSYLINGERIFVFSGEFHYWRLPVPELWRDLLEKIKAAGFNAFSIYNSWGYHEASPGALDFKNGAHDFESIMTLAKELGLYLLIRPGPYVNAEANAGGFPLWVTTGEYGKLRNDDPRFTKAWSKYWTEISKVIEPHLITNGGNVAMFQIENELGGQWKNDDKRILNEPVANYMQLLKDAARDAGIDVPVFHNAPNTRTFSWSNDFEANATGNVDVTGVDSYPSCWSCNLDECTGTNGEYVPYNIQDYVTYFSKQSPAQPHFLPEFQGGSYNPWGGPEGGCPGDIGPDFANIFYRDLVAQQATAISLYMMYGGTNWGWFACPVVATSYDYSSPISENREIWDKYYETKSLTLFTRVAHDLTKTNRVTNSTSLSTNDDVLVTELRHEDNGAAFYVSRHDHSPSGTKETFKIRVNTSEGKLTIPQNDHITINGHQSKIIPTDFHFGEKTLLYTTAEVLTYSVIDKKEVIVLWLPEGEHGEFTLKGHTELKHDKSLKGINVKAGKKSITVNYTQKKGLFTLNMKDGSTIVLADRQTAYKFWAPTLDNDPFAPVNKTVLVHGPYLVRHATVKNGQLNIEGDLDKSTDITVFASESLKSISWNGEKVKVSSKEGHKYTAKLKGPSKVKLPKLESWKYTDSLPEIKSDYKTSSSAWVVADKKNTTNAVLVPDLKNPVLYVDEYNVHYGNHIYRATFPTTDKAPTGVYLNLTGGLAFGYSVWLNSDYVGSYLGNATVGRSGQEFSFKNATLSKKENVLVVLMDNSGHDLRDGALDPRGITNATLIGSAKGGYKFSEWKIAGHAGSVEGEVIDPVRGPLNEGGLYAERIGAHLPGFSDKKWKSFSSKQGTLVNPSAGVRAYRTTVDLDIPDGVDVGISFKLTAPSNTTFSPTKKGYSNRVRVLLFVNGYQYGRFNPYIGNQVSFPVPPGVLNYSGENTIAVTVWSQSAEGGEVKVEWEVDYAHSSSFDVKFDSEYLRPEWTEDRLQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YMW0</accession>
    <name>A0A1C3YMW0_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FGRAMPH1_01T13225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
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            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="SCB65827.1"/>
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    <dbReference type="STRING" id="229533.A0A1C3YMW0"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="SCB65827.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="120" mass="13143" checksum="950163D21007CD6A" modified="2016-11-02" version="1">MHFAVAFTTLTALAMGVAADPNSKPPPNANVISARIWGDSDCGAKNNDHNLGEVTLHGDDDGKCSKFSDEVKSVKQYEHDYNCKLVLYSDKNCKRGKKDIKDGQCRATSSHFGSYKVECK</sequence>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
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                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
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            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
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            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    </reference>
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        <source>
            <dbReference type="EMBL" id="SCB65898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="39" mass="4753" checksum="FA993743A1B0524D" modified="2016-11-02" version="1">MAHPHELFNFAHRHASLKFERFEPRRLKEVLCTDDRNTC</sequence>
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<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3YN40</accession>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
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                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
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                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
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                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
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                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
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                <person name="Mauceli E.W."/>
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                <person name="Mitterbauer R."/>
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                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
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                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
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                <person name="Turgeon B.G."/>
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                <person name="Yoder O."/>
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                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
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            <dbReference type="DOI" id="10.1038/nature08850"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
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                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SCB65926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970333">
        <property type="protein sequence ID" value="SCB65922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3YN62"/>
    <dbReference type="SMR" id="A0A1C3YN62"/>
    <dbReference type="STRING" id="229533.A0A1C3YN62"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G14711"/>
    <dbReference type="eggNOG" id="KOG2912">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1C3YN62"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="METTL16/RlmF"/>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
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        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
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    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SCB65922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="460" mass="52628" checksum="0486D2CB8604439E" modified="2016-11-02" version="1">MGEKRKASQDLQNYRLPVDNGDTNQPTATASTLIGPAQDNVARDRHYAELYAKAPDFQQLALQDTDFARLWNQHKSDFFNDPECVMQLTKTLLKLDFGLQLELPNDRLLLDTSTYEKHAQDVVGLDIGTGASCIYPLLGCTERNWNFIATDIDSKSLEYARKNATLNNLDQRIKIVDRKWTDNLIPLDELHIPRIAFTMSNPPFYKSEQELVESAKKKSQAPFTACTGAKVEMITTGGEVAFVDRILNESLVLRDRVQWYTSMFGFQSSLVRFVDKLKENNICNYAVTEFVQGSQTRRWAIAWSFESMRPSQDVARGTKNSLSKNALPDITEETVVDLPFHGSISNFADQFRAELEKLELLSWEWDAERLEGTGRAAGRVWARAWRRKKQRADEEDARSESTKCVFAFRVSIRFDKDFMSVSCRWLEGHDPVTFDSFRGHVKKTVKSIFVRSVSEMHTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I1R9S9</accession>
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            <fullName evidence="2">Chromosome 1, complete genome</fullName>
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        <name evidence="3" type="primary">FG00237.1</name>
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        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
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        <name type="synonym">Fusarium graminearum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="2">PH-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315866.1">
        <property type="nucleotide sequence ID" value="XM_011317564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1R9S9"/>
    <dbReference type="STRING" id="229533.I1R9S9"/>
    <dbReference type="EnsemblFungi" id="CEF72118">
        <property type="protein sequence ID" value="CEF72118"/>
        <property type="gene ID" value="FGRRES_00237"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00237"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00633"/>
    <dbReference type="eggNOG" id="ENOG502RS2N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026450_1_0_1"/>
    <dbReference type="InParanoid" id="I1R9S9"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF64">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEF72118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="474" mass="51163" checksum="508E0451AC77D0B0" modified="2012-06-13" version="1">MNPSGNTKQSQASRLGDNFVRLEDYGLHQPSAQQKLTPLDMNLPRLYGARWILCFPLLPESDKLQVYNKLKQGLAHTVVSIPWITGTIGPEEGRDPDDGKIQILESPGPISFPYKDLTGIIPSYSELKEQNFPLSALSTAQLGPIDAMPQGPQQPVFVAQANFVEGGLLLTVGVHHSACDASALDAIVSTWAHNTAAVSDGTRSFAPFDEQSNDRSSLMKGNIDTESGDSCGYVLMPTPPQSNQAMPVFEMPPLSSRLFRFSSESLKNLKEAAEAFSTHDALLAFIWHHMNLARVKSGVFTNPPGDADVSALCVAVNVRNRISPPLPPSYLGNASMPCVTDKLPVSAIISGISLPRVAATIRRSLAAFTNPSRVSATIGLLDSRTNPTDYKLAFNAFLGPDVVESSWTDLGVYGNVWGAMGMLDAFRIPGEGSDGVITILPRLKDESLEVVIGLKTEAMEKLLDEESFVQAVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>I1R9Y2</accession>
    <name>I1R9Y2_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alkyl transferase</fullName>
            <ecNumber evidence="3">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FG00298.1</name>
        <name evidence="5" type="ORF">FGRAMPH1_01T00797</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2014-02" db="EMBL/GenBank/DDBJ databases">
            <title>A revised Fusarium graminearum genomic reference sequence using whole shotgun re-sequencing.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>PH-1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="4">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="3"/>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315946.1">
        <property type="nucleotide sequence ID" value="XM_011317644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1R9Y2"/>
    <dbReference type="FunCoup" id="I1R9Y2">
        <property type="interactions" value="412"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1R9Y2"/>
    <dbReference type="EnsemblFungi" id="CEF72201">
        <property type="protein sequence ID" value="CEF72201"/>
        <property type="gene ID" value="FGRRES_00298"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00298"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00797"/>
    <dbReference type="eggNOG" id="KOG1602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038505_0_2_1"/>
    <dbReference type="InParanoid" id="I1R9Y2"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="208"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CEF72201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="363" mass="41475" checksum="931C20001A702629" modified="2012-06-13" version="1">MADAISSFIRRVIVESPPGEWAMRQLRDLLIGALKQGPIPQHVSFEMDGNRRYARNHRMEALEGHHRGFEALARIMEICYKSGVKVVTVYAFSIENFNRPAREVEGLMELAKTKLEQLTKYGHILDRYGARVRVLGQREMIREDVLQVVDKAVARTRHNNKAVLNICFPYTSRAEITTAVKSTVQEFLAPSPPRSTPFSPSRIRRKILSRQLDDREGLPMIPDTVTEETEPSSGDDIKKDSDGDSSSPTLLPDSPPPRQRARNSAASLSGLPNPETITAETLDKHMYTANDPPLDIFVRTSGVERLSDFMLWQCHQDTQIFFIDTLWPDFDLKDFIWILLEWQWRQKQKDRDDTTVRPTSVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I1R9Z6</accession>
    <accession>A0A098D1A0</accession>
    <name>I1R9Z6_GIBZE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome 1, complete genome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FG00313.1</name>
        <name evidence="4" type="ORF">FGRAMPH1_01T00829</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
            <strain evidence="4">PH-1</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblFungi"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="CEF72217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011315961.1">
        <property type="nucleotide sequence ID" value="XM_011317659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1R9Z6"/>
    <dbReference type="SMR" id="I1R9Z6"/>
    <dbReference type="STRING" id="229533.I1R9Z6"/>
    <dbReference type="EnsemblFungi" id="CEF72217">
        <property type="protein sequence ID" value="CEF72217"/>
        <property type="gene ID" value="FGRRES_00313"/>
    </dbReference>
    <dbReference type="KEGG" id="fgr:FGSG_00313"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G00829"/>
    <dbReference type="eggNOG" id="ENOG502SNQY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027371_3_1_1"/>
    <dbReference type="InParanoid" id="I1R9Z6"/>
    <dbReference type="OrthoDB" id="5229455at2759"/>
    <dbReference type="PHI-base" id="PHI:1989"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="83"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CEF72217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblFungi" id="CEF72217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070720"/>
        </source>
    </evidence>
    <sequence length="449" mass="51682" checksum="F0777BBB81AA6922" modified="2012-06-13" version="1">MDMPQGFSPGMLSFPDQDFDYSAFLQADDITFGESAQSQLPSTSDSSDKATPPSGSSSEVAVQRPSAQKQRLERRGHTKSRRGCYNCKRRRIKCQETHPACGHCTKTGLKCEYPSTPQITHQPHHQVPLFSLQDMRFFQHFLTQCYPHHPLKQEDIWTHEIPCIAHNNEYLMHAILGFSASELMRDDPSILSSAMNHRIKAIRAIKKRLAETNKSSMNYEEANAMVATCFALTFQSVSLDDGLAEYLTFIRGIMIVGMQMMFRGIKPIFENMFEQDQDALLEPLMQGLPLIPKGFTDSAFEALTNLKPLCTEEVELEYHQHLMAMVEKLYVNSWDAYKAYTTQYGWWMLLPHDTFQSLIDPDNQVMLLLHTHWVAINEIITPISGQERNVSNKYPPDQREGKPDLDPGFSRWLKYLNQSIDLEHQIYNQWPMWVEEKLDNDVTFFGRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I1RAV6</accession>
    <name>I1RAV6_GIBZE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="9">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FGRAMPH1_01T01625</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)</name>
        <name type="common">Wheat head blight fungus</name>
        <name type="synonym">Fusarium graminearum</name>
        <dbReference type="NCBI Taxonomy" id="229533"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="1400" last="1402">
            <title>The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Gueldener U."/>
                <person name="Xu J.-R."/>
                <person name="Trail F."/>
                <person name="Turgeon B.G."/>
                <person name="Di Pietro A."/>
                <person name="Walton J.D."/>
                <person name="Ma L.-J."/>
                <person name="Baker S.E."/>
                <person name="Rep M."/>
                <person name="Adam G."/>
                <person name="Antoniw J."/>
                <person name="Baldwin T."/>
                <person name="Calvo S.E."/>
                <person name="Chang Y.-L."/>
                <person name="DeCaprio D."/>
                <person name="Gale L.R."/>
                <person name="Gnerre S."/>
                <person name="Goswami R.S."/>
                <person name="Hammond-Kosack K."/>
                <person name="Harris L.J."/>
                <person name="Hilburn K."/>
                <person name="Kennell J.C."/>
                <person name="Kroken S."/>
                <person name="Magnuson J.K."/>
                <person name="Mannhaupt G."/>
                <person name="Mauceli E.W."/>
                <person name="Mewes H.-W."/>
                <person name="Mitterbauer R."/>
                <person name="Muehlbauer G."/>
                <person name="Muensterkoetter M."/>
                <person name="Nelson D."/>
                <person name="O'Donnell K."/>
                <person name="Ouellet T."/>
                <person name="Qi W."/>
                <person name="Quesneville H."/>
                <person name="Roncero M.I.G."/>
                <person name="Seong K.-Y."/>
                <person name="Tetko I.V."/>
                <person name="Urban M."/>
                <person name="Waalwijk C."/>
                <person name="Ward T.J."/>
                <person name="Yao J."/>
                <person name="Birren B.W."/>
                <person name="Kistler H.C."/>
            </authorList>
            <dbReference type="PubMed" id="17823352"/>
            <dbReference type="DOI" id="10.1126/science.1143708"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2010" name="Nature" volume="464" first="367" last="373">
            <title>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.</title>
            <authorList>
                <person name="Ma L.J."/>
                <person name="van der Does H.C."/>
                <person name="Borkovich K.A."/>
                <person name="Coleman J.J."/>
                <person name="Daboussi M.J."/>
                <person name="Di Pietro A."/>
                <person name="Dufresne M."/>
                <person name="Freitag M."/>
                <person name="Grabherr M."/>
                <person name="Henrissat B."/>
                <person name="Houterman P.M."/>
                <person name="Kang S."/>
                <person name="Shim W.B."/>
                <person name="Woloshuk C."/>
                <person name="Xie X."/>
                <person name="Xu J.R."/>
                <person name="Antoniw J."/>
                <person name="Baker S.E."/>
                <person name="Bluhm B.H."/>
                <person name="Breakspear A."/>
                <person name="Brown D.W."/>
                <person name="Butchko R.A."/>
                <person name="Chapman S."/>
                <person name="Coulson R."/>
                <person name="Coutinho P.M."/>
                <person name="Danchin E.G."/>
                <person name="Diener A."/>
                <person name="Gale L.R."/>
                <person name="Gardiner D.M."/>
                <person name="Goff S."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Hilburn K."/>
                <person name="Hua-Van A."/>
                <person name="Jonkers W."/>
                <person name="Kazan K."/>
                <person name="Kodira C.D."/>
                <person name="Koehrsen M."/>
                <person name="Kumar L."/>
                <person name="Lee Y.H."/>
                <person name="Li L."/>
                <person name="Manners J.M."/>
                <person name="Miranda-Saavedra D."/>
                <person name="Mukherjee M."/>
                <person name="Park G."/>
                <person name="Park J."/>
                <person name="Park S.Y."/>
                <person name="Proctor R.H."/>
                <person name="Regev A."/>
                <person name="Ruiz-Roldan M.C."/>
                <person name="Sain D."/>
                <person name="Sakthikumar S."/>
                <person name="Sykes S."/>
                <person name="Schwartz D.C."/>
                <person name="Turgeon B.G."/>
                <person name="Wapinski I."/>
                <person name="Yoder O."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhou S."/>
                <person name="Galagan J."/>
                <person name="Cuomo C.A."/>
                <person name="Kistler H.C."/>
                <person name="Rep M."/>
            </authorList>
            <dbReference type="PubMed" id="20237561"/>
            <dbReference type="DOI" id="10.1038/nature08850"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="544" last="544">
            <title>The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum.</title>
            <authorList>
                <person name="King R."/>
                <person name="Urban M."/>
                <person name="Hammond-Kosack M.C."/>
                <person name="Hassani-Pak K."/>
                <person name="Hammond-Kosack K.E."/>
            </authorList>
            <dbReference type="PubMed" id="26198851"/>
            <dbReference type="DOI" id="10.1186/s12864-015-1756-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="HG970332">
        <property type="protein sequence ID" value="SCB64096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011316337.1">
        <property type="nucleotide sequence ID" value="XM_011318035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1RAV6"/>
    <dbReference type="FunCoup" id="I1RAV6">
        <property type="interactions" value="465"/>
    </dbReference>
    <dbReference type="STRING" id="229533.I1RAV6"/>
    <dbReference type="KEGG" id="fgr:FGSG_00645"/>
    <dbReference type="VEuPathDB" id="FungiDB:FGRAMPH1_01G01625"/>
    <dbReference type="eggNOG" id="KOG2587">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023294_0_0_1"/>
    <dbReference type="InParanoid" id="I1RAV6"/>
    <dbReference type="OrthoDB" id="272392at2759"/>
    <dbReference type="Proteomes" id="UP000070720">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055207">
        <property type="entry name" value="POLR3C_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013197">
        <property type="entry name" value="RNA_pol_III_RPC82-rel_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008806">
        <property type="entry name" value="RNA_pol_III_Rpc82_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08221">
        <property type="entry name" value="HTH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05645">
        <property type="entry name" value="RNA_pol_Rpc82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22536">
        <property type="entry name" value="WHD_POLR3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase III subunit RPC82-related helix-turn-helix" evidence="12">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III Rpc82 C -terminal" evidence="11">
        <location>
            <begin position="160"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase III subunit RPC3 winged-helix" evidence="13">
        <location>
            <begin position="474"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="344"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016689"/>
        </source>
    </evidenc
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